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chr15:40,778,506-42,749,023

Best TWAS P=1.69e-12 · Best GWAS P=2.71e-13 conditioned to 0.00149

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	-6.2	5.9	3.9e-09	0.64	0.65	0.31	FALSE
2	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	-4.5	-5.5	2.9e-08	-0.69	0.99	0.01	FALSE
3	GTEx	Brain Cerebellum	OIP5	0.16	0.09	lasso	4	0.16	1.8e-05	-3.9	-5.2	2.0e-07	-0.74	0.18	0.41	FALSE
4	GTEx	Brain Cerebellum	NDUFAF1	0.24	0.26	lasso	8	0.20	1.1e-06	-4.0	5.3	1.2e-07	0.59	0.64	0.34	FALSE
5	GTEx	Brain Frontal Cortex BA9	OIP5	0.13	0.00	enet	16	0.01	2.1e-01	-1.9	-5.6	2.3e-08	-0.41	0.04	0.46	FALSE
6	GTEx	Brain Frontal Cortex BA9	NUSAP1	0.39	0.42	enet	22	0.42	2.0e-12	-3.9	-5.2	1.7e-07	-0.68	0.90	0.10	FALSE
7	GTEx	Brain Hippocampus	NUSAP1	0.30	0.25	enet	14	0.26	1.0e-06	-3.9	-5.1	2.9e-07	-0.68	0.18	0.62	FALSE
8	GTEx	Brain Hypothalamus	NUSAP1	0.26	0.36	lasso	4	0.27	5.6e-07	-5.7	-5.4	6.7e-08	-0.64	0.41	0.51	FALSE
9	GTEx	Brain Hypothalamus	NDUFAF1	0.24	0.12	lasso	5	0.13	5.9e-04	-5.5	5.3	1.2e-07	0.61	0.08	0.69	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	NDUFAF1	0.12	0.11	lasso	6	0.10	9.7e-04	-4.7	5.1	2.7e-07	0.60	0.32	0.16	FALSE
11	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	-4.7	-5.4	5.5e-08	-0.71	0.92	0.08	FALSE
12	GTEx	Breast Mammary Tissue (Male)	OIP5-AS1	0.26	0.10	enet	20	0.22	7.3e-06	-4.5	-5.4	8.7e-08	-0.63	0.22	0.44	FALSE
13	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	-4.7	-5.5	3.4e-08	-0.75	0.15	0.84	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	NDUFAF1	0.35	0.46	enet	14	0.51	3.1e-19	-4.1	5.4	6.0e-08	0.63	1.00	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	NDUFAF1	0.26	0.15	lasso	8	0.20	2.8e-15	-5.5	5.5	3.8e-08	0.61	1.00	0.00	FALSE
16	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	-6.3	7.1	1.7e-12	0.73	0.12	0.71	TRUE
17	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	-6.3	5.9	3.7e-09	0.63	0.71	0.29	FALSE
18	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	-5.7	6.0	2.1e-09	0.75	0.54	0.46	FALSE
19	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	-6.3	-6.3	3.0e-10	-0.74	0.30	0.70	FALSE
20	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	-3.8	-5.4	5.1e-08	-0.67	0.95	0.05	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	NDUFAF1	0.16	0.06	lasso	3	0.07	1.7e-04	-6.3	5.5	3.6e-08	0.55	0.05	0.54	FALSE
22	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	-6.3	6.3	3.5e-10	0.69	0.31	0.42	FALSE
23	GTEx	Thyroid	RTF1	0.28	0.27	lasso	3	0.26	8.4e-20	6.4	6.6	5.7e-11	0.91	0.03	0.97	FALSE
24	NTR	Blood	RTF1	0.04	0.02	blup	338	0.03	6.9e-09	5.8	-5.9	4.0e-09	-0.68	0.19	0.81	FALSE
25	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	-4.8	-5.7	9.0e-09	-0.58	0.10	0.27	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	-6.4	6.3	2.5e-10	0.75	0.01	0.90	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC729082	0.02	0.01	blup	44	0.02	2.9e-04	-4.9	5.1	2.8e-07	0.69	0.20	0.66	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	6.4	6.7	2.9e-11	0.91	0.00	0.98	FALSE