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chr4:38,079,294-39,824,758

Best TWAS P=1.11e-67 · Best GWAS P=5.59e-73 conditioned to 2.9e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TLR1	0.04	0.03	lasso	4	0.03	8.2e-05	-16.9	17.4	1.1e-67	-0.92	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TLR6	0.13	0.05	bslmm	513	0.08	2.1e-10	1.2	-5.3	1.2e-07	0.08	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	TLR1	0.08	0.07	lasso	2	0.07	1.3e-08	-15.6	-16.6	9.3e-62	0.89	0.21	0.79	FALSE
8	GTEx	Esophagus Mucosa	TLR1	0.20	0.02	lasso	6	0.04	9.8e-04	-14.2	15.8	1.5e-56	-0.87	0.05	0.95	FALSE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TLR1	0.14	0.07	enet	12	0.10	1.7e-05	-14.9	15.2	6.1e-52	-0.79	0.28	0.66	FALSE
13	GTEx	Testis	FAM114A1	0.37	0.20	lasso	7	0.20	2.2e-09	-16.4	-15.0	5.4e-51	0.80	0.41	0.58	FALSE
18	YFS	Blood	TLR6	0.05	0.04	bslmm	505	0.06	1.3e-18	-15.6	14.5	1.6e-47	-0.82	0.92	0.08	FALSE
7	GTEx	Cells Transformed fibroblasts	TLR6	0.28	0.19	lasso	5	0.17	1.7e-12	-14.2	14.4	3.9e-47	-0.77	1.00	0.00	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	TLR1	0.08	0.02	blup	514	0.03	2.3e-05	-14.9	-14.3	4.4e-46	0.68	0.03	0.97	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TLR6	0.03	0.02	lasso	2	0.01	3.5e-02	-14.2	14.2	1.6e-45	-0.76	0.06	0.09	FALSE
17	YFS	Blood	TLR1	0.08	0.05	bslmm	525	0.07	1.2e-20	-17.8	14.0	7.7e-45	-0.72	0.09	0.91	FALSE
28	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TLR1	0.13	0.13	enet	3	0.08	2.6e-03	-10.5	13.4	4.2e-41	-0.78	0.01	0.76	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	TLR6	0.29	0.03	lasso	11	0.08	4.8e-05	5.6	13.3	3.4e-40	-0.66	0.63	0.25	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TLR10	0.09	0.06	lasso	2	0.06	2.3e-04	-11.9	12.0	4.9e-33	-0.56	0.16	0.06	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TLR1	0.03	0.03	enet	23	0.03	1.5e-04	-16.9	11.3	1.9e-29	-0.65	0.04	0.86	FALSE
5	GTEx	Breast Mammary Tissue	FAM114A1	0.11	0.04	lasso	3	0.05	1.0e-03	-15.6	-11.0	3.5e-28	0.64	0.24	0.32	FALSE
9	GTEx	Esophagus Mucosa	FAM114A1	0.14	0.03	lasso	11	0.03	6.6e-03	6.9	-10.4	1.6e-25	0.51	0.57	0.29	FALSE
14	NTR	Blood	TLR1	0.03	0.00	bslmm	520	0.01	3.0e-03	-16.9	10.1	6.6e-24	-0.55	0.06	0.47	FALSE
10	GTEx	Esophagus Muscularis	TLR1	0.21	0.02	enet	46	0.06	2.3e-04	-14.1	9.8	6.8e-23	-0.54	0.07	0.79	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TLR10	0.08	0.01	blup	517	0.03	3.4e-05	-7.5	9.4	4.9e-21	-0.56	0.65	0.19	FALSE
12	GTEx	Skin Sun Exposed Lower leg	TLR6	0.17	0.12	lasso	7	0.10	1.6e-08	5.6	9.0	3.2e-19	-0.42	1.00	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Female)	FAM114A1	0.07	-0.01	lasso	4	0.01	1.7e-01	-4.6	-7.7	1.9e-14	0.51	0.04	0.15	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	TLR6	0.07	0.02	blup	65	0.01	4.7e-02	7.9	-7.3	2.5e-13	0.48	0.08	0.07	FALSE
3	GTEx	Adipose Subcutaneous	FAM114A1	0.21	0.17	lasso	5	0.17	9.5e-14	-1.0	-6.8	1.5e-11	0.38	1.00	0.00	FALSE
4	GTEx	Artery Coronary	RP11-360F5.3	0.21	0.11	enet	32	0.00	4.2e-01	0.5	-6.6	5.2e-11	0.39	0.18	0.33	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TLR6	0.10	0.13	lasso	1	0.10	4.4e-05	5.6	5.6	2.6e-08	-0.24	0.37	0.03	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TLR1	0.08	0.02	enet	11	0.04	1.1e-03	-10.5	5.1	3.0e-07	-0.29	0.02	0.05	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	TLR6	0.06	0.04	lasso	3	0.04	1.1e-04	-3.9	-5.1	3.0e-07	0.36	0.10	0.25	FALSE