[Hub]/) : Traits : Hayfever, allergic rhinitis or eczema :

chr4:38,079,294-39,824,758

Best TWAS P=1.11e-67 · Best GWAS P=5.59e-73 conditioned to 2.9e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TLR1 0.08 0.07 lasso 2 0.07 1.3e-08 -15.6 -16.6 9.3e-62 0.89 0.21 0.79 FALSE
2 CommonMind Brain Pre-frontal Cortex TLR6 0.13 0.05 bslmm 513 0.08 2.1e-10 1.2 -5.3 1.2e-07 0.08 1.00 0.00 TRUE
3 GTEx Adipose Subcutaneous FAM114A1 0.21 0.17 lasso 5 0.17 9.5e-14 -1.0 -6.8 1.5e-11 0.38 1.00 0.00 FALSE
4 GTEx Artery Coronary RP11-360F5.3 0.21 0.11 enet 32 0.00 4.2e-01 0.5 -6.6 5.2e-11 0.39 0.18 0.33 FALSE
5 GTEx Breast Mammary Tissue FAM114A1 0.11 0.04 lasso 3 0.05 1.0e-03 -15.6 -11.0 3.5e-28 0.64 0.24 0.32 FALSE
6 GTEx Breast Mammary Tissue (Female) FAM114A1 0.07 -0.01 lasso 4 0.01 1.7e-01 -4.6 -7.7 1.9e-14 0.51 0.04 0.15 FALSE
7 GTEx Cells Transformed fibroblasts TLR6 0.28 0.19 lasso 5 0.17 1.7e-12 -14.2 14.4 3.9e-47 -0.77 1.00 0.00 FALSE
8 GTEx Esophagus Mucosa TLR1 0.20 0.02 lasso 6 0.04 9.8e-04 -14.2 15.8 1.5e-56 -0.87 0.05 0.95 FALSE
9 GTEx Esophagus Mucosa FAM114A1 0.14 0.03 lasso 11 0.03 6.6e-03 6.9 -10.4 1.6e-25 0.51 0.57 0.29 FALSE
10 GTEx Esophagus Muscularis TLR1 0.21 0.02 enet 46 0.06 2.3e-04 -14.1 9.8 6.8e-23 -0.54 0.07 0.79 FALSE
11 GTEx Skin Not Sun Exposed Suprapubic TLR6 0.29 0.03 lasso 11 0.08 4.8e-05 5.6 13.3 3.4e-40 -0.66 0.63 0.25 FALSE
12 GTEx Skin Sun Exposed Lower leg TLR6 0.17 0.12 lasso 7 0.10 1.6e-08 5.6 9.0 3.2e-19 -0.42 1.00 0.00 FALSE
13 GTEx Testis FAM114A1 0.37 0.20 lasso 7 0.20 2.2e-09 -16.4 -15.0 5.4e-51 0.80 0.41 0.58 FALSE
14 NTR Blood TLR1 0.03 0.00 bslmm 520 0.01 3.0e-03 -16.9 10.1 6.6e-24 -0.55 0.06 0.47 FALSE
15 ROSMAP Brain Pre-frontal Cortex TLR10 0.08 0.01 blup 517 0.03 3.4e-05 -7.5 9.4 4.9e-21 -0.56 0.65 0.19 FALSE
16 ROSMAP Brain Pre-frontal Cortex TLR1 0.08 0.02 blup 514 0.03 2.3e-05 -14.9 -14.3 4.4e-46 0.68 0.03 0.97 FALSE
17 YFS Blood TLR1 0.08 0.05 bslmm 525 0.07 1.2e-20 -17.8 14.0 7.7e-45 -0.72 0.09 0.91 FALSE
18 YFS Blood TLR6 0.05 0.04 bslmm 505 0.06 1.3e-18 -15.6 14.5 1.6e-47 -0.82 0.92 0.08 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TLR6 0.03 0.02 lasso 2 0.01 3.5e-02 -14.2 14.2 1.6e-45 -0.76 0.06 0.09 FALSE
20 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TLR1 0.04 0.03 lasso 4 0.03 8.2e-05 -16.9 17.4 1.1e-67 -0.92 0.01 0.99 TRUE
21 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TLR10 0.09 0.06 lasso 2 0.06 2.3e-04 -11.9 12.0 4.9e-33 -0.56 0.16 0.06 FALSE
22 The Cancer Genome Atlas Liver Hepatocellular Carcinoma TLR1 0.14 0.07 enet 12 0.10 1.7e-05 -14.9 15.2 6.1e-52 -0.79 0.28 0.66 FALSE
23 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TLR1 0.03 0.03 enet 23 0.03 1.5e-04 -16.9 11.3 1.9e-29 -0.65 0.04 0.86 FALSE
24 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TLR1 0.08 0.02 enet 11 0.04 1.1e-03 -10.5 5.1 3.0e-07 -0.29 0.02 0.05 FALSE
25 The Cancer Genome Atlas Pancreatic Adenocarcinoma TLR6 0.10 0.13 lasso 1 0.10 4.4e-05 5.6 5.6 2.6e-08 -0.24 0.37 0.03 FALSE
26 The Cancer Genome Atlas Prostate Adenocarcinoma TLR6 0.07 0.02 blup 65 0.01 4.7e-02 7.9 -7.3 2.5e-13 0.48 0.08 0.07 FALSE
27 The Cancer Genome Atlas Thyroid Carcinoma TLR6 0.06 0.04 lasso 3 0.04 1.1e-04 -3.9 -5.1 3.0e-07 0.36 0.10 0.25 FALSE
28 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TLR1 0.13 0.13 enet 3 0.08 2.6e-03 -10.5 13.4 4.2e-41 -0.78 0.01 0.76 FALSE