Best TWAS P=4.13e-25 · Best GWAS P=2.19e-29 conditioned to 0.316
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | 7.96 | -10.4 | 4.1e-25 | -0.76 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | PAFAH1B2 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.3e-01 | 6.14 | -6.7 | 2.5e-11 | -0.42 | 0.06 | 0.22 | TRUE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | 7.92 | -8.0 | 1.1e-15 | -0.48 | 0.19 | 0.08 | FALSE |
| 3 | GTEx | Colon Sigmoid | PCSK7 | 0.28 | 0.09 | lasso | 8 | 0.15 | 6.5e-06 | 6.49 | -5.7 | 1.3e-08 | -0.39 | 0.82 | 0.01 | FALSE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | 0.11 | -5.7 | 1.5e-08 | -0.22 | 0.02 | 0.04 | FALSE |
| 4 | GTEx | Testis | TAGLN | 0.15 | 0.05 | lasso | 5 | 0.04 | 8.0e-03 | 5.24 | -5.5 | 3.0e-08 | -0.32 | 0.36 | 0.03 | FALSE |