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chr12:111,154,626-113,517,494

Best TWAS P=1.37e-11 · Best GWAS P=9.83e-16 conditioned to 1.57e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ATXN2 0.02 0.03 enet 8 0.02 4.8e-04 -4.0 5.5 4.8e-08 0.56 0.26 0.65 FALSE
2 GTEx Adipose Subcutaneous HECTD4 0.06 0.00 enet 15 0.02 1.0e-02 -4.4 5.2 1.7e-07 0.65 0.06 0.85 FALSE
3 GTEx Adipose Subcutaneous MAPKAPK5-AS1 0.08 0.01 enet 26 0.03 2.1e-03 -5.4 -5.2 2.5e-07 -0.44 0.97 0.02 FALSE
4 GTEx Adipose Subcutaneous AC003029.1 0.08 0.07 enet 30 0.05 1.2e-04 -4.4 -5.2 1.7e-07 -0.47 1.00 0.00 FALSE
5 GTEx Artery Aorta AC003029.1 0.07 0.01 lasso 7 0.01 5.4e-02 -5.7 -5.3 1.1e-07 -0.43 0.22 0.19 FALSE
6 GTEx Artery Tibial HECTD4 0.05 0.02 lasso 3 0.01 3.1e-02 5.9 6.1 9.8e-10 0.78 0.01 0.93 FALSE
7 GTEx Brain Frontal Cortex BA9 ALDH2 0.33 0.04 enet 24 0.09 2.0e-03 -4.0 5.5 2.9e-08 0.33 0.09 0.08 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic MAPKAPK5-AS1 0.04 0.00 enet 30 0.00 7.0e-01 -4.5 -5.2 1.5e-07 -0.53 0.22 0.13 FALSE
9 GTEx Skin Sun Exposed Lower leg ALDH2 0.10 0.09 enet 13 0.13 6.7e-11 -4.0 5.7 1.5e-08 0.62 0.97 0.03 FALSE
10 GTEx Thyroid BRAP 0.07 0.02 lasso 7 0.03 1.1e-03 -5.4 -5.5 3.5e-08 -0.54 0.29 0.53 FALSE
11 GTEx Thyroid ALDH2 0.06 0.04 lasso 4 0.05 9.7e-05 -5.7 5.3 1.2e-07 0.47 0.88 0.06 FALSE
12 YFS Blood SH2B3 0.05 0.01 enet 22 0.02 3.3e-07 -5.4 6.8 1.4e-11 0.64 0.57 0.43 TRUE
13 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP29 0.11 0.03 blup 25 0.05 5.0e-03 -4.3 -5.4 5.3e-08 -0.60 0.01 0.75 FALSE