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chr1:108,854,166-110,931,112

Best TWAS P=4.27e-55 · Best GWAS P=6.65e-56 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-15.6	-15.6	5.6e-55	0.97	0.01	0.99	TRUE
5	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-15.6	-15.6	4.3e-55	1.00	0.01	0.99	FALSE
13	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-15.7	-15.6	7.2e-55	0.99	0.00	1.00	FALSE
7	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-15.6	-15.5	2.7e-54	1.00	0.01	0.99	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-15.6	-15.3	1.4e-52	0.96	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-14.8	-14.9	4.6e-50	0.95	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-15.7	-14.8	1.1e-49	0.94	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-14.8	-14.4	3.3e-47	0.92	0.01	0.99	FALSE
17	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-15.6	-13.4	3.2e-41	0.87	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-13.2	-13.2	1.2e-39	0.75	0.01	0.84	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-15.6	-12.9	3.1e-38	0.82	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-13.2	-12.6	1.9e-36	0.80	0.02	0.91	FALSE
12	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-13.2	-12.4	4.5e-35	0.75	0.01	0.97	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-15.6	-12.3	8.2e-35	0.77	0.01	0.92	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-15.6	-11.6	5.9e-31	0.73	0.01	0.78	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-15.6	-11.3	1.3e-29	0.77	0.00	0.98	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-15.7	-10.8	4.0e-27	0.58	0.00	0.80	FALSE
6	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	-1.7	-10.1	3.7e-24	0.69	0.08	0.77	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	2.6	-10.0	1.7e-23	0.63	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-11.3	9.9	3.7e-23	-0.58	0.10	0.32	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-9.1	-9.6	9.8e-22	0.67	0.01	0.38	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-15.6	-9.5	1.5e-21	0.63	0.00	0.80	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	2.0	-9.0	2.7e-19	0.50	0.18	0.57	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MYBPHL	0.09	0.07	blup	46	0.06	5.7e-04	1.2	-7.0	3.3e-12	0.55	0.03	0.51	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	CELSR2	0.08	0.00	blup	62	0.02	8.1e-03	-1.7	-6.7	3.0e-11	0.50	0.01	0.29	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	AMIGO1	0.08	0.03	blup	404	0.03	8.7e-05	-4.1	-6.6	3.8e-11	0.25	0.93	0.01	FALSE
10	GTEx	Pituitary	AC000032.2	0.36	-0.01	enet	1	0.05	1.8e-02	-6.6	-6.6	4.2e-11	0.45	0.05	0.12	FALSE
8	GTEx	Nerve Tibial	SYPL2	0.09	0.00	enet	27	0.05	1.9e-04	-6.2	6.3	2.9e-10	-0.34	0.08	0.27	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSRC1	0.18	0.10	enet	11	0.10	1.6e-10	2.0	-6.0	2.3e-09	0.38	1.00	0.00	FALSE
9	GTEx	Pituitary	GPSM2	0.27	0.04	lasso	5	0.10	2.2e-03	2.2	5.7	1.3e-08	-0.23	0.03	0.45	FALSE
4	GTEx	Esophagus Mucosa	SORT1	0.20	0.07	lasso	6	0.04	6.7e-04	1.0	-5.5	3.5e-08	0.29	0.18	0.22	FALSE
11	GTEx	Prostate	RP11-20O24.4	0.33	0.01	enet	30	0.13	3.2e-04	-5.4	-5.1	3.0e-07	0.37	0.04	0.32	FALSE