Best TWAS P=1.86e-14 · Best GWAS P=6.69e-14 conditioned to 0.000283
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -4.6 | 5.6 | 1.7e-08 | -0.02 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Artery Tibial | EME2 | 0.09 | 0.03 | enet | 21 | 0.04 | 2.8e-04 | 4.7 | 5.2 | 2.5e-07 | -0.01 | 0.16 | 0.03 | TRUE |
| 3 | GTEx | Nerve Tibial | AXIN1 | 0.11 | 0.09 | lasso | 2 | 0.06 | 3.9e-05 | -7.0 | 6.3 | 3.3e-10 | -0.78 | 0.04 | 0.94 | FALSE |
| 4 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -6.3 | 7.2 | 7.2e-13 | -0.77 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -7.0 | 6.6 | 5.6e-11 | -0.74 | 0.03 | 0.88 | FALSE |
| 6 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -7.0 | -6.7 | 1.7e-11 | 0.81 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 3.5 | 6.4 | 1.3e-10 | -0.62 | 0.02 | 0.96 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.3 | 5.7 | 1.6e-08 | 0.03 | 0.04 | 0.96 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | MRPL28 | 0.17 | 0.10 | lasso | 5 | 0.12 | 1.1e-15 | 2.6 | 5.4 | 7.9e-08 | -0.47 | 1.00 | 0.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -5.2 | -6.9 | 6.4e-12 | 0.77 | 0.06 | 0.94 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NME4 | 0.07 | 0.01 | blup | 45 | 0.03 | 2.3e-04 | -5.5 | 6.1 | 1.1e-09 | -0.51 | 0.06 | 0.35 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -6.9 | 7.5 | 4.7e-14 | -0.80 | 0.01 | 0.75 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -4.8 | -7.7 | 1.9e-14 | 0.58 | 0.01 | 0.56 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | enet | 12 | 0.03 | 2.5e-04 | 2.7 | -5.5 | 3.7e-08 | 0.38 | 0.01 | 0.09 | FALSE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100134368 | 0.08 | 0.07 | blup | 48 | 0.06 | 1.9e-03 | 3.5 | -5.8 | 7.9e-09 | 0.47 | 0.05 | 0.14 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AXIN1 | 0.07 | 0.03 | blup | 88 | 0.05 | 3.5e-06 | -2.7 | 5.5 | 4.1e-08 | -0.57 | 0.41 | 0.48 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -6.1 | -6.9 | 4.3e-12 | 0.65 | 0.02 | 0.82 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | ARHGDIG | 0.09 | 0.01 | blup | 56 | 0.03 | 3.7e-04 | 3.8 | 5.3 | 1.2e-07 | -0.50 | 0.02 | 0.20 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 3.5 | -6.6 | 3.1e-11 | 0.53 | 0.46 | 0.38 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -4.6 | 5.9 | 4.2e-09 | -0.01 | 0.00 | 0.98 | TRUE |