Best TWAS P=8.02e-14 · Best GWAS P=6.68e-12 conditioned to 0.681
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | S100PBP | 0.05 | 0.04 | enet | 10 | 0.02 | 1.2e-03 | -6.9 | 5.8 | 5.4e-09 | -0.97 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | 1.6 | -7.4 | 9.9e-14 | 0.41 | 0.10 | 0.32 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | -5.8 | -5.8 | 5.5e-09 | 0.09 | 0.78 | 0.21 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | -5.9 | 6.0 | 1.9e-09 | -0.06 | 0.36 | 0.64 | TRUE |
5 | GTEx | Muscle Skeletal | FNDC5 | 0.15 | 0.16 | enet | 5 | 0.16 | 1.9e-15 | -6.2 | -6.3 | 3.2e-10 | 0.96 | 0.10 | 0.90 | FALSE |
6 | METSIM | Adipose | PEF1 | 0.03 | 0.02 | enet | 17 | 0.02 | 7.9e-04 | -5.0 | 5.3 | 1.5e-07 | 0.09 | 0.35 | 0.20 | TRUE |
7 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | -5.9 | -5.6 | 1.8e-08 | 0.05 | 0.37 | 0.63 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PEF1 | 0.04 | 0.04 | lasso | 3 | 0.02 | 4.2e-04 | -4.9 | 5.2 | 2.0e-07 | 0.11 | 0.54 | 0.34 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FNDC5 | 0.02 | 0.01 | blup | 33 | 0.01 | 9.2e-03 | -5.4 | -5.7 | 1.2e-08 | 0.79 | 0.02 | 0.44 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | -6.8 | 5.9 | 3.6e-09 | -0.91 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | -6.4 | 7.5 | 8.0e-14 | -0.91 | 0.01 | 0.82 | TRUE |
12 | The Cancer Genome Atlas | Glioblastoma Multiforme | S100PBP | 0.21 | 0.15 | lasso | 5 | 0.15 | 2.9e-05 | -6.2 | 6.2 | 4.4e-10 | -0.96 | 0.01 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | S100PBP | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -6.8 | 6.8 | 1.1e-11 | -1.00 | 0.00 | 0.99 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC5 | 0.03 | 0.04 | enet | 6 | 0.03 | 2.9e-04 | -6.4 | -5.6 | 1.9e-08 | 0.80 | 0.02 | 0.95 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HPCA | 0.05 | 0.09 | lasso | 7 | 0.08 | 3.6e-09 | -5.3 | 5.8 | 6.2e-09 | -0.78 | 0.12 | 0.88 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | S100PBP | 0.06 | 0.06 | blup | 47 | 0.05 | 5.2e-06 | -6.8 | 7.0 | 1.9e-12 | -0.92 | 0.00 | 1.00 | FALSE |