TWAS hub - HPCA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1120	0.0360	3.5e-10	0.091	0.095	0.085	0.096	0.089	3.8e-11	1.2e-11	1.7e-10	1.0e-11	6.4e-11
2	ROSMAP	Brain Pre-frontal Cortex	0.0473	0.0201	4.9e-04	0.025	0.021	0.018	0.020	0.017	2.6e-04	9.4e-04	1.8e-03	1.1e-03	2.5e-03
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0539	0.0225	6.4e-09	0.093	0.077	0.077	NA	0.079	1.4e-10	4.9e-09	4.9e-09	NA	3.6e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2011)	8.0	7.8	8.3	2.7	2.8	2.9
Qualifications: None of the above	7.1	15.1	16.1	4.0	3.8	3.9
Miserableness	6.5	11.2	14.7	3.8	2.9	3.3
Leg fat mass (left)	6.2	24.1	26.6	5.2	4.5	5.1
Hearing difficulty/problems: Yes	6.1	9.3	12.8	3.2	2.2	3.6
Taking other prescription medications	6.0	9.2	14.3	3.8	1.6	3.3
Mood swings	5.9	10.6	13.6	3.7	2.8	3.2
Happiness	5.7	6.9	11.2	-1.2	-3.4	-2.8
Leg fat mass (right)	5.7	22.3	24.1	4.8	4.4	4.9
Weight	5.1	25.2	29.5	5.0	4.6	5.4
Whole body fat mass	5.1	21.3	23.0	4.8	4.4	4.7
Hip circumference	5.0	21.6	23.9	4.5	4.5	4.9
Risk taking	4.9	7.2	9.8	2.4	2.4	3.1
Arm predicted mass (left)	4.9	25.0	31.7	5.1	4.2	5.6
Ovarian Cancer	4.7	6.2	7.9	-2.7	-1.9	-2.8
Waist circumference	4.7	17.2	22.4	4.3	3.3	4.7
Arm fat mass (right)	4.7	19.5	22.7	4.8	4.0	4.5
Arm fat mass (left)	4.6	19.1	21.5	4.5	3.9	4.6
BMI	4.5	26.1	33.8	5.0	4.4	5.8
Chronotype (morning person)	4.5	10.5	18.0	-4.2	-1.9	-3.1
Trunk fat mass	4.5	19.2	21.6	4.7	4.3	4.2
Commuting to job workplace: Public transport	4.5	5.4	7.6	2.4	1.6	2.8
Arm fat-free mass (left)	4.5	22.9	28.3	4.9	4.0	5.3
Depressed Affect (Nagel 2018)	4.4	9.2	13.5	3.7	2.5	2.8
Body mass index (BMI)	4.4	18.8	23.1	4.4	3.8	4.8
Arm fat-free mass (right)	4.3	22.2	29.1	4.7	4.0	5.4
Medication: Seretide 50 evohaler	4.2	4.9	5.5	2.0	2.3	2.3
Arm predicted mass (right)	4.1	21.0	28.3	4.4	3.9	5.3
Asthma	3.8	7.6	11.8	3.4	2.2	2.5
Leg fat percentage (left)	3.8	13.8	14.7	3.8	3.6	3.7
Leg fat percentage (right)	3.7	13.5	14.1	3.6	3.7	3.8
Family relationship satisfaction	3.7	4.5	6.2	-1.6	-2.2	-2.5
Qualifications: nursing, teaching	3.7	5.7	10.2	-3.2	-1.9	-1.9
Basal metabolic rate	3.6	19.9	26.2	4.5	3.7	5.1
Noisy workplace	3.5	4.3	7.3	2.7	1.6	1.8
Body fat percentage	3.5	13.7	15.5	3.9	3.8	3.4
Tinnitus: Yes, now most or all of the time	3.5	4.1	4.4	2.1	1.9	2.1
Number of treatments/medications taken	3.4	6.1	11.3	3.4	1.3	2.3
Asthma (self-reported)	3.4	6.7	10.7	3.3	2.0	2.3
Fluid intelligence score	3.3	6.9	10.6	-3.3	-2.4	-2.1
Illnesses of father: None of the above (group 1)	3.3	4.0	5.3	-1.5	-2.3	-2.2
Trunk fat percentage	3.2	12.9	15.0	3.9	3.8	3.1
Medication: Cholesterol lowering	3.2	5.0	7.7	2.3	1.5	2.8
Qualifications: College or University degree	3.2	10.1	16.0	-2.5	-4.0	-2.8
Respiratory disease	3.1	6.9	11.1	3.3	2.2	2.2
Age when periods started (menarche)	3.1	7.3	14.5	-3.8	-1.6	-2.3
Leg fat-free mass (left)	3.0	15.8	20.4	4.0	3.3	4.5
Leg predicted mass (left)	3.0	16.1	20.3	4.1	3.3	4.5
Whole body fat-free mass	3.0	17.0	23.1	4.1	3.4	4.8
Medication: Aspirin	3.0	3.9	5.4	2.3	0.9	2.3
Average weekly champagne plus white wine intake	3.0	4.1	5.5	1.8	2.4	1.8
Pack years of smoking	3.0	4.4	7.3	2.7	1.1	2.2
Medication for hormone replacement therapy	2.9	3.2	5.9	-0.6	-2.4	-1.8
Maternal smoking around birth	2.9	4.2	5.4	2.3	2.0	1.8
Qualifications: A levels/AS levels or equivalent	2.9	6.5	11.2	-2.0	-3.3	-2.1
Leg pain on walking	2.9	3.7	6.0	1.9	2.5	1.3
Whole body water mass	2.9	16.6	22.9	4.0	3.3	4.8
Severe depression (siblings)	2.8	3.1	3.7	-1.7	-1.6	-1.9
Shortness of breath walking on level ground	2.8	3.3	4.0	1.6	2.0	1.8
Prostate Cancer	2.7	3.8	7.7	-1.6	-2.8	-1.0
Diabetes (self-reported)	2.7	4.1	5.8	1.9	1.7	2.4
Arm fat percentage (right)	2.7	10.5	13.2	3.6	2.9	3.1
Leg predicted mass (right)	2.7	14.1	17.9	4.0	3.0	4.2
Supplements: Fish oil (including cod liver oil)	2.7	3.5	4.2	2.0	2.0	1.5
Angina	2.6	3.4	5.2	0.7	2.1	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	4.4	2.1	1.9	1.6
Trunk fat-free mass	2.6	15.0	21.5	3.6	3.2	4.6
Peak expiratory flow (PEF)	2.6	6.1	7.5	2.0	2.7	2.6
Exposure to tobacco smoke outside home	2.6	3.4	4.5	2.1	1.6	1.8
Wheeze or whistling in the chest in last year	2.6	4.6	8.2	2.9	1.1	2.1
Leg fat-free mass (right)	2.6	14.1	17.8	4.0	2.9	4.2
Irritability	2.6	4.4	5.6	2.2	1.6	2.4
Trunk predicted mass	2.5	14.3	20.7	3.6	3.1	4.5
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	5.4	-1.9	-2.3	-1.7
Medication for pain relief, constipation, heartburn	2.5	4.3	5.1	-1.8	-2.3	-2.1
Arm fat percentage (left)	2.5	10.0	11.7	3.4	2.9	3.1
Bipolar Disorder (2018)	2.4	3.7	5.8	2.4	1.4	1.9
Diabetes (father)	2.4	3.0	4.1	2.0	1.6	1.5
Impedance of arm (right)	2.4	11.0	20.8	-2.6	-2.3	-4.6
Father’s age at death	2.4	3.2	4.2	-1.7	-1.5	-2.1
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	7.2	-2.7	-0.4	-2.2
Age at first live birth	2.4	4.2	5.3	-2.3	-1.7	-2.1
Comparative height size at age 10	2.4	13.3	13.5	3.7	3.7	3.6
Heart disease (siblings)	2.4	2.9	4.7	2.2	1.6	1.3
Lung FVC	2.3	11.5	16.6	-4.1	-1.7	-3.9
Ever had hysterectomy (womb removed)	2.3	2.5	2.8	1.6	1.7	1.5
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	5.6	2.4	1.1	1.1
Impedance of arm (left)	2.3	10.6	18.7	-3.0	-2.0	-4.3
Pack years adult smoking proportion	2.2	3.4	5.6	2.4	1.0	1.9
Supplements: Glucosamine	2.2	2.8	3.9	1.4	2.0	1.6
Pain all over the body in last month	2.2	2.3	5.1	0.8	1.1	2.3
Birth weight of first child	2.2	4.0	5.1	2.0	1.7	2.2
Mineral and other dietary supplements	2.2	3.0	3.9	-1.8	-2.0	-1.4
Medication: Paracetamol	2.2	3.4	4.0	1.9	1.6	2.0
Supplements: Calcium	2.2	2.5	3.2	1.1	1.8	1.7
Hand grip strength (left)	2.1	5.5	6.3	-2.4	-2.5	-2.1
Alcohol intake versus 10 years previously	2.1	3.1	4.2	2.0	1.8	1.5
Medication: Lansoprazole	2.1	2.3	3.6	1.9	0.9	1.6
Age at last live birth	2.1	3.0	5.0	-2.2	-1.4	-1.5
Medication: Aspirin	2.1	2.8	4.0	2.0	0.7	2.0
Diabetes diagnosed by doctor	2.1	3.5	4.4	1.9	1.5	2.1
Mouth/teeth dental problems	2.0	3.0	3.8	-2.0	-1.7	-1.5
Health satisfaction	2.0	2.6	4.1	1.4	-2.0	-1.3
Angina (self-reported)	2.0	2.6	4.0	0.3	2.0	2.0
Type 2 Diabetes (T2D) (2018)	1.9	3.5	5.5	1.7	1.4	2.3
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.1	2.5	0.7	1.7
Overall health rating	1.9	4.0	10.0	3.2	-0.4	1.4
Medication: Paracetamol	1.8	2.9	3.1	1.7	1.8	1.7
Nervous feelings	1.7	3.1	5.3	-1.4	-2.3	-1.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	5.2	2.3	1.3	1.8
Friendships satisfaction	1.7	2.1	3.9	-0.5	-2.0	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	6.4	-2.5	-0.4	-2.0
Hearing aid user	1.7	1.9	3.0	1.7	0.9	1.4
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.0	2.0	1.3	0.8
Medication: Levothyroxine sodium	1.6	2.7	3.2	1.8	1.5	1.6
Illnesses of father: Heart disease	1.6	2.3	4.5	1.5	0.4	2.1
Medication for cholesterol	1.6	2.5	7.4	-0.1	2.7	0.3
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.2	0.6	1.4	1.8
Unable to work because of sickness or disability	1.6	2.1	2.6	1.6	1.3	1.4
Bipolar Disorder or Schizophrenia	1.5	3.7	4.5	1.9	1.7	2.1
Verbal and Numeric Reasoning (VNR)	1.5	3.5	6.1	-2.5	-1.6	-1.4
Chronic bronchitis/emphysema (father)	1.5	1.7	4.2	0.9	2.0	0.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.0	1.6	0.1	1.7
Osteoporosis (self-reported)	1.5	1.8	2.6	1.6	1.4	1.0
Medication: Simvastatin	1.4	2.1	4.0	1.5	0.1	2.0
Mouth/teeth dental problems: Dentures	1.4	2.4	3.6	0.8	1.9	1.7
Pulse wave reflection index	1.4	1.8	2.5	-0.6	-1.6	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.4	-0.9	-0.9	-1.8
Age started oral contraceptive pill	1.4	1.8	4.1	-2.0	-0.8	-0.8
Impedance of whole body	1.4	7.2	15.4	-2.1	-1.3	-3.9
Alzheimer’s Disease (in mother)	1.3	1.5	1.7	1.2	1.3	1.1
Hypothyroidism (self reported)	1.3	3.0	4.5	2.1	1.1	1.8
Sitting height	1.3	9.1	10.8	2.7	3.3	3.1
Medication: Ramipril	1.3	1.6	3.6	1.9	0.4	1.0
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.3	1.1	0.2	1.8
Medication: Atorvastatin	1.3	1.6	3.8	0.6	0.9	1.9
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.9	2.0	0.3	1.0
Depression (Nagel 2018)	1.2	1.8	2.1	1.1	1.4	1.4
Intelligence (Savage-Jansen 2018)	1.2	3.5	6.7	-2.6	-1.2	-1.6
HbA1C	1.2	1.3	2.2	1.3	0.4	1.5
Blood Eosinophil Count	1.2	8.9	19.3	4.4	0.8	2.6
Medication: Metformin	1.2	1.7	1.9	1.4	1.2	1.3
Townsend deprivation index at recruitment	1.2	1.7	2.8	1.7	0.5	1.4
Fed-up feelings	1.2	2.2	4.2	2.0	0.9	1.2
Had other major operations	1.2	1.5	1.8	1.3	1.0	1.3
Allergy	1.2	2.9	6.2	-2.5	-1.3	-0.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.7	-0.8	-1.6	-1.2
Alcohol intake frequency.	1.2	2.8	5.4	1.3	2.3	1.1
Major Depression (MDD)	1.1	1.4	2.8	-1.1	-1.7	-0.0
Neuroticism (2016)	1.1	1.6	3.2	1.8	-0.0	1.3
Medication: Allopurinol	1.1	1.5	2.8	1.0	0.8	1.7
Suffer from ‘nerves’	1.1	1.8	3.0	-0.6	-1.7	-1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.8	0.5	1.7	0.8
Ever smoked	1.1	1.9	3.7	1.3	0.6	1.9
Fractured/broken bones in last 5 years	1.1	1.4	2.5	1.6	0.6	1.2
Serious illness, injury or assault to yourself	1.0	1.3	3.3	1.8	0.6	0.5
Illnesses of siblings	1.0	1.5	2.3	-1.5	-1.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.6	-1.6	0.2	-0.9
Pulse wave Arterial Stiffness index	1.0	1.1	2.0	-0.7	-0.9	-1.4
Number of children fathered	1.0	1.1	2.7	0.7	1.6	0.4
Number of self-reported non-cancer illnesses	1.0	1.8	3.6	1.9	-0.1	1.3
Medication: Blood pressure	1.0	2.0	5.9	0.1	-2.4	-0.1
Number of operations (self-reported)	1.0	1.4	1.5	1.1	1.2	1.2
Cholesterol lowering medication	1.0	1.5	2.9	1.1	-0.7	1.7
HDL Cholesterol	0.9	1.4	2.5	0.1	1.6	1.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.4	1.5	0.3	0.7
Height	0.9	16.9	20.2	4.0	3.8	4.5
Smoking Status	0.9	2.1	3.2	1.8	0.6	1.7
Depression (self-reported)	0.9	1.1	1.8	-0.0	-1.2	-1.3
Prospective memory result	0.9	1.0	1.4	-1.2	-0.8	-1.1
Gout (self-reported)	0.9	1.2	1.6	0.8	1.1	1.2
Pulse wave peak to peak time	0.9	1.1	2.0	0.7	0.9	1.4
Neck or shoulder pain in last month	0.9	1.3	3.6	1.9	0.5	0.3
Medication: Blood pressure	0.9	1.6	2.9	1.7	-0.1	1.4
Illnesses of siblings: Diabetes	0.9	1.1	2.1	1.0	1.5	-0.3
Neuroticism (Nagel 2018)	0.8	2.0	4.0	2.0	0.5	1.2
Fasting Glucose	0.8	1.0	2.2	0.7	0.4	1.5
Primary Biliary Cirrhosis	0.8	1.2	2.2	1.5	0.4	1.1
Schizophrenia (2014)	0.8	1.7	3.0	0.9	1.1	1.7
Frequency of depressed mood in last 2 weeks	0.8	1.2	1.5	1.2	1.0	1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.2	0.1	-1.8	-0.1
Current tobacco smoking	0.8	1.3	2.5	1.6	0.4	1.2
Past tobacco smoking	0.8	1.5	2.5	-1.4	-0.5	-1.6
Hearing difficulty/problems with background noise	0.8	1.2	3.1	1.8	0.1	0.8
Illnesses of mother	0.8	1.0	2.2	-1.0	0.1	-1.5
Blood clot in the leg (DVT)	0.8	1.1	2.8	1.7	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.8	1.0	0.6	1.4
Osteoarthritis (self-reported)	0.8	1.1	2.1	0.8	1.4	0.8
Medication: Gliclazide	0.8	1.0	1.3	0.9	0.9	1.2
Worry (Nagel 2018)	0.7	1.5	1.8	-1.0	-1.4	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.4	0.7	1.0	1.2
Triglycerides	0.7	1.1	1.8	1.3	0.4	1.1
Cardiovascular Disease	0.7	2.4	2.7	1.5	-1.5	1.6
Average weekly spirits intake	0.7	0.9	1.7	0.6	1.3	0.8
Sensitivity / hurt feelings	0.7	1.1	1.9	1.4	0.9	0.8
Impedance of leg (right)	0.7	3.2	6.6	-1.7	-0.3	-2.6
High blood pressure (mother)	0.7	1.0	2.6	-0.4	-1.6	-0.5
Birth weight	0.7	1.6	2.2	1.0	1.5	1.3
Comparative body size at age 10	0.7	1.8	3.3	1.1	1.0	1.8
Medication: Ibuprofen	0.7	0.9	2.1	0.5	1.4	0.5
Hypertension (Self-reported)	0.7	2.0	5.1	0.5	-2.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	1.3	0.0	0.9
Loneliness, isolation	0.7	0.9	2.0	1.4	0.6	0.7
Commuting to job workplace: Walk	0.7	0.7	1.0	-0.6	-0.9	-1.0
Schizophrenia vs Biploar Disorder	0.6	0.7	0.9	-0.8	-0.8	-1.0
Vitamin and mineral supplements	0.6	0.9	1.2	-1.0	-1.1	-0.6
Diabetes (mother)	0.6	0.8	1.6	0.7	0.4	1.2
High blood pressure	0.6	1.7	4.3	0.6	-2.1	0.6
Impedance of leg (left)	0.6	2.9	7.1	-1.2	-0.4	-2.7
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.5	-1.9	0.2	-1.5
Standing height	0.6	6.2	8.0	2.2	2.8	2.3
Worry too long after embarrassment	0.6	1.0	2.5	0.7	-1.6	-0.0
Medication: Omeprazole	0.6	0.7	1.6	1.3	0.3	0.7
Knee pain experienced in last month	0.6	0.9	2.7	0.3	1.6	0.1
Long-standing illness, disability or infirmity	0.6	0.9	1.8	0.4	-1.4	-0.8
Ever taken oral contraceptive pill	0.6	0.7	1.8	-1.3	0.2	0.4
High cholesterol (Self-reported)	0.6	1.1	2.7	0.4	-0.7	1.6
Breast Cancer	0.5	1.1	2.6	-1.6	-0.1	-0.9
Ulcerative Colitis	0.5	0.7	1.6	0.6	0.2	1.3
Blood Red Count	0.5	5.1	12.8	3.6	0.2	1.5
Lung FEV1/FVC ratio	0.5	2.6	6.5	-2.5	-0.7	-0.9
Neuroticism	0.5	1.1	3.1	1.8	-0.1	0.5
Supplements: Zinc	0.5	0.5	0.8	-0.6	-0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	-1.2	0.5	0.3
Number of incorrect matches in round	0.5	0.9	1.2	1.0	-0.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	0.9	0.0	1.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	1.1	0.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.8	0.7	-0.9	0.6
Neuroticism score	0.5	1.0	2.5	1.6	0.2	0.7
Falls in the last year	0.5	0.7	1.1	0.8	-1.0	-0.6
Number of full brothers	0.5	0.7	2.0	-0.2	1.4	-0.1
Heart disease (mother)	0.5	0.6	1.2	1.1	-0.1	0.8
Number of full sisters	0.5	0.6	1.2	-0.5	-1.1	-0.5
Smoking status: Current	0.5	0.9	1.9	1.4	-0.1	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	-1.3	0.0	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.0	-0.7	1.7	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.0	1.0	0.3	0.8
Schizophrenia (2018)	0.4	0.9	1.5	0.5	1.0	1.2
Ulcerative Colitis (UC)	0.4	0.8	2.4	-0.1	0.1	1.5
Body Mass Index (BMI) (2010)	0.4	0.5	1.2	1.1	0.1	0.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-0.1	-0.4	-1.1
Heart attack	0.4	0.5	0.8	0.9	0.4	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.8	-1.3	1.0	-1.0
Tense / ‘highly strung’	0.4	0.7	1.5	-1.2	-0.3	-0.8
Medication: Amlodipine	0.4	0.6	1.5	-0.3	-1.2	0.3
Pulse rate, automated reading	0.4	1.2	2.9	1.7	-0.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	1.2	-0.0	0.2
Smoking status: Previous	0.4	0.6	1.0	0.5	0.6	1.0
Financial situation satisfaction	0.4	0.5	1.2	0.1	-1.1	-0.5
Alcohol drinker status: Never	0.4	0.5	0.7	-0.7	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.9	0.4	0.7
Mean Putamen Volume	0.3	0.3	0.6	-0.3	-0.8	-0.5
Allergy or Eczema	0.3	0.7	1.7	0.6	1.3	-0.2
Systolic blood pressure, automated reading	0.3	0.9	1.4	0.9	0.6	1.2
Hand grip strength (right)	0.3	0.8	1.8	-1.3	-0.6	-0.5
Multivitamins +/- minerals	0.3	0.3	0.6	-0.1	0.8	0.6
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.8	-0.5	-0.3
Medication: Atenolol	0.3	0.4	0.9	-0.9	-0.6	-0.1
Number of live births	0.3	0.4	0.7	-0.8	-0.6	-0.4
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.2	0.7	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	0.4	-0.8	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.7	0.6	0.2
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	-0.4	1.7	-0.3
Mean time to correctly identify matches	0.3	0.5	1.4	0.2	1.2	0.1
Chest pain or discomfort	0.3	0.5	0.7	0.7	0.4	0.9
Supplements: Vitamin C	0.3	0.3	0.6	0.8	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	0.8	1.0	-0.0
Average weekly red wine intake	0.3	0.5	0.7	-0.8	-0.8	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.9	-0.5	0.0
Ever had bowel cancer screening	0.3	0.4	0.9	0.4	1.0	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.5	-0.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.2	0.3	-0.9
Wears glasses or contact lenses	0.3	0.4	1.1	-0.1	-1.1	-0.0
Mother’s age at death	0.3	0.3	0.7	-0.5	-0.8	-0.1
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.0	-0.8	0.7
Medication: Lisinopril	0.3	0.4	0.4	0.6	-0.6	0.6
Crohns Disease (2017)	0.2	0.5	1.1	-1.1	-0.5	-0.4
Reaction Time	0.2	0.4	1.0	0.2	1.0	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.7	0.8	0.2	-0.3
Lupus	0.2	0.3	1.0	1.0	0.0	-0.1
Blood Platelet Count	0.2	2.5	4.2	-0.0	2.1	1.8
Blood White Count	0.2	1.7	2.6	1.6	0.3	1.6
Tanning	0.2	2.2	2.4	-1.4	-1.5	-1.5
Relative age of first facial hair	0.2	0.3	0.5	0.7	-0.3	-0.7
Medication: Co-codamol	0.2	0.2	0.7	0.1	0.2	0.8
Had menopause	0.2	0.2	0.4	0.6	0.5	-0.0
Financial difficulties in last 2 years	0.2	0.2	0.6	0.8	-0.2	-0.0
Worrier / anxious feelings	0.2	0.4	0.9	0.1	-0.9	-0.6
Lung cancer (father)	0.2	0.2	0.5	0.7	0.3	-0.3
Length of working week for main job	0.2	0.3	0.7	-0.3	-0.1	-0.8
Breastfed as a baby	0.2	0.2	0.6	-0.8	-0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	-0.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.3	-0.0	-0.8
Headache pain in last month	0.2	0.3	0.7	0.8	-0.5	0.2
High blood pressure (siblings)	0.2	0.2	0.7	-0.0	-0.2	-0.8
Migraine (self-reported)	0.2	0.2	0.7	0.2	0.1	-0.8
Had major operations	0.2	0.2	0.3	0.2	0.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.7	0.6	0.2
Eye problems/disorders: Cataract	0.2	0.2	0.6	0.7	-0.2	-0.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.6	0.3	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.4	0.3	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.6	-0.1	0.6
Crohns Disease (2012)	0.1	0.2	0.2	-0.5	-0.4	-0.3
LDL Cholesterol	0.1	0.1	0.3	0.2	0.6	0.2
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	0.1	-0.3
Waist Hip Ratio (WHR)	0.1	0.6	1.2	1.1	-0.6	0.6
Systolic Blood Pressure	0.1	0.5	1.0	0.8	-1.0	0.2
Hair Pigment	0.1	2.5	2.9	-1.3	-1.7	-1.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.4	-0.5	-0.2
Relative age voice broke	0.1	0.2	0.2	0.4	-0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.2	0.3	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.2	0.3	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.7	0.5	-0.4
Alcohol usually taken with meals	0.1	0.2	0.4	-0.4	0.7	-0.2
Forced vital capacity (FVC)	0.1	0.6	0.7	-0.8	0.8	-0.6
Time employed in main current job	0.1	0.1	0.2	-0.4	-0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.1	0.5	-0.1
Hair/balding pattern: Pattern 4	0.1	0.4	0.5	-0.7	-0.2	-0.7
Loud music exposure frequency	0.1	0.1	0.2	0.0	-0.4	-0.3
Glaucoma (self-reported)	0.1	0.2	0.2	-0.2	-0.5	-0.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.2	-0.2	0.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	0.2	0.5
Back pain experienced in last month	0.1	0.1	0.4	0.6	-0.1	0.2
Guilty feelings	0.1	0.1	0.2	0.4	-0.3	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.4	0.3	0.1
Average weekly beer plus cider intake	0.1	0.1	0.2	0.0	-0.4	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.6	0.7	-0.1	0.8
Ever depressed for a whole week	0.1	0.1	0.3	-0.0	-0.5	-0.0
Commuting to job workplace: Cycle	0.1	0.1	0.1	-0.3	-0.3	-0.2
Myopia	0.1	0.1	0.3	-0.1	-0.3	-0.5
Pain experienced in last month	0.1	0.2	0.5	-0.7	0.1	-0.2
Age at First Birth	0.0	0.1	0.1	0.2	-0.1	-0.3
Heel T-Score	0.0	0.0	0.0	-0.1	-0.2	-0.0
Average weekly fortified wine intake	0.0	0.0	0.0	-0.0	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	0.2	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.0	-0.1	-0.0
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.2	-0.2	-0.1
Pulse rate	0.0	0.1	0.2	0.5	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.1	-0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.2	0.1	-0.2
Breast cancer (self-reported)	0.0	0.0	0.1	0.0	-0.2	-0.3
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.2	-0.0	0.0

Hub : Genes

HPCA

Models

Trait associations