Best TWAS P=5.78e-18 · Best GWAS P=3.05e-18 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CPSF4 | 0.06 | 0.06 | blup | 313 | 0.07 | 6.6e-09 | -8.7 | -8.1 | 4.5e-16 | 0.90 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LOC100289187 | 0.08 | 0.02 | enet | 14 | 0.03 | 4.5e-05 | -7.5 | 6.6 | 3.9e-11 | -0.83 | 0.22 | 0.78 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GS1-259H13.2 | 0.23 | 0.12 | lasso | 1 | 0.09 | 1.8e-05 | -7.5 | 7.5 | 5.1e-14 | -0.75 | 0.86 | 0.04 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CPSF4 | 0.08 | 0.03 | lasso | 4 | 0.03 | 1.8e-03 | -7.5 | -7.8 | 9.0e-15 | 0.77 | 0.22 | 0.46 | FALSE |
| 5 | GTEx | Esophagus Mucosa | GS1-259H13.2 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.7e-04 | -7.5 | 7.7 | 1.8e-14 | -0.78 | 0.36 | 0.49 | FALSE |
| 6 | GTEx | Lung | ZKSCAN5 | 0.09 | 0.05 | lasso | 2 | 0.03 | 2.7e-03 | -7.5 | 7.5 | 6.3e-14 | -0.74 | 0.34 | 0.23 | FALSE |
| 7 | GTEx | Lung | GS1-259H13.2 | 0.09 | 0.07 | lasso | 4 | 0.05 | 8.4e-05 | -7.5 | 7.5 | 6.3e-14 | -0.74 | 0.76 | 0.10 | FALSE |
| 8 | GTEx | Nerve Tibial | GS1-259H13.2 | 0.15 | 0.10 | lasso | 4 | 0.09 | 3.4e-07 | -7.5 | 7.4 | 1.4e-13 | -0.73 | 0.98 | 0.01 | FALSE |
| 9 | GTEx | Thyroid | ARPC1B | 0.36 | 0.10 | lasso | 8 | 0.13 | 4.2e-10 | -3.8 | -5.5 | 3.5e-08 | 0.47 | 0.98 | 0.02 | FALSE |
| 10 | GTEx | Thyroid | ARPC1A | 0.11 | 0.03 | lasso | 5 | 0.06 | 4.6e-05 | -3.3 | -6.3 | 2.6e-10 | 0.67 | 0.91 | 0.02 | FALSE |
| 11 | GTEx | Thyroid | GS1-259H13.2 | 0.26 | 0.05 | enet | 30 | 0.08 | 7.6e-07 | -7.7 | 6.4 | 1.6e-10 | -0.58 | 0.88 | 0.06 | FALSE |
| 12 | METSIM | Adipose | ARPC1A | 0.02 | 0.02 | blup | 308 | 0.02 | 1.6e-03 | -6.0 | -7.1 | 9.7e-13 | 0.84 | 0.06 | 0.89 | FALSE |
| 13 | METSIM | Adipose | GS1-259H13.2 | 0.04 | 0.03 | lasso | 3 | 0.02 | 1.4e-03 | -7.7 | 7.7 | 1.5e-14 | -0.74 | 0.22 | 0.74 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | ARPC1A | 0.02 | 0.00 | bslmm | 264 | 0.00 | 9.2e-02 | -2.5 | 5.4 | 6.4e-08 | -0.61 | 0.08 | 0.25 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | GS1-259H13.2 | 0.07 | 0.05 | bslmm | 305 | 0.06 | 6.9e-08 | -7.5 | 7.7 | 1.6e-14 | -0.81 | 0.32 | 0.68 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZKSCAN5 | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.0e-04 | -8.6 | -8.6 | 5.8e-18 | 0.99 | 0.01 | 0.99 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZKSCAN5 | 0.03 | 0.03 | enet | 8 | 0.03 | 5.4e-04 | -8.7 | -6.8 | 1.2e-11 | 0.83 | 0.01 | 0.86 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | ARPC1B | 0.06 | 0.07 | lasso | 2 | 0.06 | 2.0e-06 | -6.0 | -6.0 | 2.1e-09 | 0.76 | 0.29 | 0.70 | FALSE |