Hub : Genes

ARPC1B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.3590	0.0810	2.2e-09	0.104	NA	0.096	NA	0.129	2.3e-08	NA	8.0e-08	NA	4.3e-10
2	YFS	Blood	0.0527	0.0183	2.4e-12	0.040	0.040	0.042	0.04	0.037	4.5e-13	3.7e-13	1.6e-13	4.4e-13	3.3e-12
3	TCGA	Thyroid Carcinoma	0.0550	0.0290	9.4e-06	0.065	0.047	0.048	NA	0.059	5.8e-07	2.0e-05	1.8e-05	NA	2.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.5	2.3	5.2	-2.3	-0.8	-1.1
Bipolar Disorder or Schizophrenia	0.4	1.1	2.6	-1.6	-0.5	-0.6
Depressed Affect (Nagel 2018)	1.0	2.0	3.6	-0.4	-1.9	-1.5
Depression (Nagel 2018)	1.6	2.3	3.5	-0.5	-1.8	-1.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.5	-0.1	-1.6	-1.1
Neuroticism (Nagel 2018)	0.3	0.7	1.9	0.3	-1.4	-0.4
Schizophrenia (2018)	0.1	0.1	0.2	-0.3	-0.5	0.1
Schizophrenia vs Biploar Disorder	1.8	2.3	4.0	2.0	-0.0	1.7
Worry (Nagel 2018)	0.3	0.7	1.5	1.2	-0.2	0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.6	0.3	-0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.1	0.6	0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	0.3	0.9	0.8
Crohns Disease (2017)	3.7	8.0	20.4	4.5	-0.6	1.8
Irritable Bowel Disease (IBD)	4.3	10.2	27.2	5.2	-0.5	1.8
Ulcerative Colitis (UC)	2.5	4.6	12.7	3.6	-0.0	1.1
Major Depression (MDD)	1.0	1.2	1.9	0.3	-1.2	-1.4
Reaction Time	1.5	3.0	4.5	-1.5	-1.4	-2.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-0.0	-1.0	-0.5
Breast Cancer	0.2	0.4	0.7	-0.4	-0.8	-0.6
Ovarian Cancer	1.0	1.3	1.9	-0.8	-1.1	-1.4
Prostate Cancer	0.2	0.3	0.7	0.9	-0.1	0.4
Age at First Birth	6.7	9.7	16.5	1.1	4.1	3.4
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.2	-0.3	-1.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.1	-0.3	-0.4
Coronary Artery Disease (CAD)	1.8	2.1	3.5	1.5	-1.9	-0.7
Crohns Disease (2012)	2.0	3.2	8.3	2.9	-0.7	0.8
Mean Putamen Volume	0.6	0.7	1.8	0.3	-1.4	0.1
Fasting Glucose	0.4	0.5	1.2	-1.1	0.6	-0.1
HbA1C	8.4	9.3	16.4	0.6	4.1	3.3
HDL Cholesterol	0.9	1.5	2.7	-0.2	1.3	1.6
LDL Cholesterol	0.1	0.2	0.3	0.6	0.5	0.2
Lupus	1.2	1.8	3.5	1.9	-1.3	-0.5
Neuroticism (2016)	0.5	0.7	0.9	0.7	-1.0	-0.9
Primary Biliary Cirrhosis	0.4	0.6	1.6	1.3	-0.2	0.0
Rheumatoid Arthritis	4.9	6.8	12.8	0.8	3.6	2.6
Schizophrenia (2014)	0.3	0.7	1.4	-0.5	-1.2	-0.6
Triglycerides	0.4	0.6	1.2	0.1	-0.9	-1.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.5	1.6	-0.6	0.3
Ulcerative Colitis	2.4	3.5	9.5	3.1	-0.6	0.8
Blood Eosinophil Count	0.4	2.9	7.6	2.8	0.2	1.1
Blood Platelet Count	0.8	9.4	15.4	1.7	-3.1	-3.9
Blood Red Count	4.0	38.3	63.2	-2.1	-8.0	-6.9
Blood White Count	3.3	24.7	35.2	-4.7	-4.1	-5.9
Heel T-Score	0.7	5.5	9.5	-3.1	-0.9	-2.5
BMI	4.3	25.0	35.9	-5.5	-2.9	-6.0
Height	0.5	10.1	11.4	3.3	2.8	3.4
Waist Hip Ratio (WHR)	0.7	3.2	5.6	-1.3	-1.5	-2.4
Systolic Blood Pressure	0.5	2.5	3.8	-0.5	-2.0	-1.9
Smoking Status	7.0	16.9	22.6	-3.9	-3.6	-4.8
Allergy or Eczema	2.7	7.0	9.6	1.9	3.1	2.8
Cardiovascular Disease	2.8	9.2	16.2	-1.5	-4.0	-3.0
Hypothyroidism (self reported)	0.7	1.6	2.8	0.7	1.2	1.7
Respiratory disease	0.5	1.1	1.4	1.2	0.6	1.2
Type 2 Diabetes (T2D) (2018)	4.2	7.9	10.6	-3.1	-1.8	-3.3
Lung FEV1/FVC ratio	0.8	3.9	5.3	1.1	-2.3	-2.3
Lung FVC	0.9	4.7	6.5	1.4	2.5	2.4
Neuroticism	0.1	0.2	0.4	0.7	-0.5	0.2
Chronotype (morning person)	2.4	5.5	8.7	1.8	2.2	3.0
Hair Pigment	0.1	2.1	2.8	-1.3	-1.4	-1.7
Tanning	0.1	0.8	1.2	0.7	1.1	0.9
Hand grip strength (left)	1.6	4.2	5.7	1.9	1.8	2.4
Number of treatments/medications taken	1.2	2.1	5.1	-0.2	-2.3	-1.1
Average weekly spirits intake	1.7	2.1	4.6	-2.1	-0.6	-1.2
Sensitivity / hurt feelings	0.4	0.7	1.7	0.5	-1.3	-0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.5	-0.8	-1.1	-1.2
Hearing difficulty/problems: Yes	0.7	1.1	3.0	0.3	-1.7	-0.6
Relative age of first facial hair	0.2	0.4	0.9	0.2	-0.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.0	0.3	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.1	-0.9	-0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	1.3	0.3	-0.1
Systolic blood pressure, automated reading	2.2	6.5	9.3	-1.4	-2.9	-3.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.8	0.2	0.1
Angina	0.8	1.0	1.5	-0.8	-0.9	-1.2
Medication for hormone replacement therapy	0.8	0.9	2.8	0.1	-1.7	-0.0
Vitamin and mineral supplements	1.0	1.4	2.6	0.4	-1.2	-1.6
Supplements: Zinc	0.5	0.5	0.8	0.1	0.9	0.9
Medication: Co-codamol	0.8	1.0	1.7	-1.3	0.4	-1.0
Medication: Metformin	1.7	2.4	4.2	-2.0	-0.6	-1.6
Diabetes (father)	2.2	2.7	4.4	1.4	2.1	1.3
Diabetes (mother)	1.5	1.9	2.5	-1.0	-1.6	-1.5
Severe depression (siblings)	0.5	0.6	0.8	-0.6	-0.9	-0.8
Pack years adult smoking proportion	3.3	5.0	6.9	-2.5	-1.5	-2.6
Impedance of leg (right)	0.5	2.6	5.8	2.4	0.3	1.4
Leg fat-free mass (left)	0.3	1.8	3.0	-1.7	0.2	-1.5
Trunk fat percentage	2.1	8.6	14.8	-2.9	-1.6	-3.8
Hand grip strength (right)	0.6	1.7	2.4	1.6	0.6	1.5
Townsend deprivation index at recruitment	1.0	1.4	2.8	-0.7	-1.0	-1.7
Current tobacco smoking	2.3	3.8	5.5	-1.5	-2.3	-1.9
Average weekly fortified wine intake	0.2	0.3	0.8	-0.2	0.9	0.1
Maternal smoking around birth	2.1	3.0	4.9	-2.2	-0.6	-2.0
Fed-up feelings	0.3	0.6	1.2	-0.7	-0.3	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.9	-0.2	-1.1	-1.4
Relative age voice broke	1.7	2.7	5.4	2.3	-0.4	1.6
Taking other prescription medications	0.4	0.6	1.1	0.7	0.4	1.0
Age when periods started (menarche)	0.3	0.7	2.1	1.4	0.3	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.2	0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	6.8	-1.3	-1.5	-2.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.8	-0.4	-0.4
Qualifications: CSEs or equivalent	1.0	1.3	3.4	-0.2	-1.8	-0.6
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-1.3	-0.1	0.2
High blood pressure	2.6	7.3	10.0	-1.4	-3.1	-3.2
Hayfever, allergic rhinitis or eczema	2.7	5.8	7.3	1.8	2.7	2.6
Multivitamins +/- minerals	1.2	1.5	1.5	-1.2	1.2	1.2
Stomach or abdominal pain in last month	0.9	1.1	2.4	-1.6	-0.1	-1.0
Supplements: Glucosamine	1.9	2.4	3.9	1.5	1.1	2.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	0.2	0.7	1.3
Medication: Atenolol	0.3	0.4	1.1	0.4	-0.1	-1.1
Medication: Levothyroxine sodium	1.0	1.6	2.8	0.9	1.1	1.7
Sitting height	1.0	7.2	10.0	3.2	2.0	2.8
Chronic bronchitis/emphysema (father)	0.8	1.0	1.8	0.8	0.7	1.3
High blood pressure (mother)	0.2	0.2	0.4	0.5	0.2	0.7
Body mass index (BMI)	3.5	15.1	22.3	-4.3	-2.2	-4.7
Impedance of leg (left)	0.5	2.4	5.7	2.4	0.2	1.3
Leg predicted mass (left)	0.3	1.7	3.0	-1.7	0.2	-1.5
Trunk fat mass	1.8	7.8	13.3	-2.9	-1.2	-3.6
Waist circumference	2.9	10.7	17.4	-3.3	-1.9	-4.2
Number of incorrect matches in round	0.4	0.6	1.2	0.7	0.4	1.1
Past tobacco smoking	6.8	12.5	18.7	3.4	2.7	4.3
Alcohol usually taken with meals	0.3	0.4	0.7	0.1	-0.8	-0.8
Nervous feelings	0.7	1.3	3.1	1.8	-0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.2	0.4	-1.1	-0.8
Hearing difficulty/problems with background noise	2.5	4.0	5.0	-1.5	-2.2	-2.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	-0.3	-0.1
Had menopause	0.1	0.1	0.1	-0.3	0.1	0.4
Had other major operations	2.9	3.6	6.7	-1.6	-1.1	-2.6
Forced vital capacity (FVC)	0.7	2.6	4.5	2.1	1.1	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	7.0	-1.3	-1.1	-2.6
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	5.5	-2.4	0.7	-0.7
Qualifications: None of the above	0.3	0.7	1.3	1.1	-0.8	-0.4
Financial difficulties in last 2 years	0.8	1.1	3.0	-1.7	-0.3	-0.4
Mouth/teeth dental problems	0.5	0.8	2.0	-0.7	1.4	0.2
Heart attack	0.2	0.3	0.4	-0.5	0.3	-0.7
Allergy	2.2	5.1	6.2	-1.8	-2.4	-2.5
Pain all over the body in last month	0.8	0.8	1.3	-1.1	-0.2	-1.1
Diabetes (self-reported)	3.5	5.3	10.6	-3.3	-0.9	-2.1
Hayfever/allergic rhinitis (self-reported)	6.6	8.8	14.8	-0.5	3.9	3.4
Medication: Ramipril	0.3	0.4	1.1	0.3	0.3	1.0
Medication: Simvastatin	2.6	3.9	5.8	-1.1	-2.1	-2.4
Fluid intelligence score	1.2	2.5	4.4	2.1	-1.8	0.2
Illnesses of siblings	1.9	2.7	6.7	0.4	1.2	2.6
Neuroticism score	0.8	1.6	3.4	-0.2	-1.9	-1.2
Weight	1.4	7.0	11.6	-2.9	-1.1	-3.4
Impedance of arm (right)	0.3	1.2	2.2	1.5	-0.5	1.1
Arm fat percentage (right)	3.1	12.2	17.6	-3.9	-2.0	-4.2
Trunk fat-free mass	0.1	0.5	1.3	-0.5	1.1	-0.2
Hip circumference	1.4	6.0	8.8	-2.6	-1.6	-3.0
Time employed in main current job	0.2	0.3	0.5	0.7	-0.6	0.1
Alcohol intake versus 10 years previously	3.3	4.9	7.8	-1.9	-1.8	-2.8
Father’s age at death	2.5	3.4	5.0	2.2	0.5	2.2
Worrier / anxious feelings	1.3	2.5	6.3	1.1	-2.5	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.5	-0.5	-1.6	-1.4
Falls in the last year	1.0	1.4	3.0	1.7	0.7	0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	0.6	0.3	1.3
Number of live births	2.0	2.8	4.9	-0.1	-2.2	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	5.0	2.2	0.5	0.7
Pulse rate	6.1	10.3	13.9	-1.9	-3.7	-3.6
Happiness	3.2	3.9	8.8	-3.0	-0.9	-1.4
Noisy workplace	0.7	0.9	1.4	0.8	-1.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.9	1.9	4.7	-2.2	1.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.7	-0.2	1.3	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	2.9	-0.4	-1.7	-1.1
Asthma	0.5	1.0	2.7	1.6	-0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.7	-1.3	0.5	-0.3
Medication: Cholesterol lowering	1.1	1.8	2.8	-0.7	-1.5	-1.7
Depression (self-reported)	1.3	1.6	4.3	-2.1	0.1	0.6
Medication: Lansoprazole	1.6	1.8	2.5	1.2	1.6	1.1
Prospective memory result	2.6	3.2	4.5	-1.6	-1.5	-2.1
Lung cancer (father)	0.7	0.8	0.9	0.9	0.9	0.8
Illnesses of mother	1.2	1.5	2.5	-0.3	1.6	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.3	2.3	0.9	1.4
Pulse wave Arterial Stiffness index	3.0	3.5	5.9	-1.1	-1.9	-2.4
Impedance of arm (left)	0.4	2.0	3.2	1.8	0.2	1.7
Arm fat mass (right)	3.0	12.5	19.1	-3.9	-1.8	-4.4
Trunk predicted mass	0.1	0.5	1.3	-0.4	1.1	-0.2
Standing height	0.5	4.9	6.0	2.5	2.0	2.2
Length of working week for main job	0.9	1.0	2.5	-0.3	1.6	0.5
Exposure to tobacco smoke at home	1.7	1.9	2.4	1.0	1.5	1.6
Breastfed as a baby	1.8	2.2	4.1	0.8	-2.0	-1.4
Tense / ‘highly strung’	0.3	0.5	0.8	-0.5	-0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	5.4	-2.3	-1.1	-1.2
Hair/balding pattern: Pattern 4	0.3	0.7	2.1	1.5	-0.2	0.2
Birth weight of first child	1.9	3.4	9.7	3.1	-0.7	-0.4
Peak expiratory flow (PEF)	1.5	3.4	4.7	2.2	1.8	1.5
Pulse wave reflection index	0.5	0.6	1.7	1.3	-0.4	-0.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	0.7	-0.7	0.1
Loud music exposure frequency	2.5	2.7	3.8	-1.3	-1.6	-2.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	3.9	-2.0	-0.1	-1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.9	-0.3	0.5
Blood clot in the leg (DVT)	1.3	1.7	3.2	-0.1	1.8	1.4
Medication: Paracetamol	1.2	1.9	3.2	-1.1	-1.8	-1.2
Headache pain in last month	0.6	1.0	3.0	1.7	-0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	3.5	1.1	1.9	1.9
Glaucoma (self-reported)	1.2	1.4	2.2	-0.0	-1.4	-1.5
Gout (self-reported)	1.0	1.4	2.7	-1.6	0.4	-1.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.5	0.6	1.5	1.9
Medication: Amlodipine	2.7	3.8	4.9	-1.4	-2.2	-2.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.3	-1.1	-0.5	-0.4
Birth weight	0.1	0.1	0.3	-0.0	0.6	-0.2
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.6	-1.6	0.3	-0.8
High blood pressure (siblings)	0.6	0.9	2.4	-0.4	-0.4	-1.6
Forced vital capacity (FVC), Best measure	1.1	4.1	5.3	2.3	1.5	2.2
Body fat percentage	2.7	10.5	17.2	-3.4	-1.6	-4.1
Leg fat percentage (right)	3.3	12.1	20.5	-3.5	-1.9	-4.5
Arm fat-free mass (right)	0.2	0.9	1.5	-0.9	0.5	-1.2
Exposure to tobacco smoke outside home	0.7	0.9	1.6	-1.3	1.1	0.0
Comparative body size at age 10	0.5	1.4	2.0	-0.9	1.4	1.2
Number of full brothers	0.8	1.0	1.6	-0.5	-1.1	-1.3
Worry too long after embarrassment	1.3	2.2	3.7	1.9	-1.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	5.7	7.4	14.1	-3.8	-1.3	-2.5
Wheeze or whistling in the chest in last year	1.4	2.4	4.2	-0.7	-1.6	-2.1
Number of children fathered	0.3	0.3	0.5	-0.3	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	5.6	-2.3	-1.3	-2.4
Age at first live birth	4.6	8.1	8.8	2.8	3.0	2.8
Pulse wave peak to peak time	3.7	4.3	6.9	1.4	2.1	2.6
Health satisfaction	1.5	2.0	2.8	-1.3	-1.3	-1.7
Shortness of breath walking on level ground	3.6	4.2	6.2	-2.5	-1.5	-2.0
Qualifications: College or University degree	0.6	1.8	3.2	-1.5	1.8	0.1
Eye problems/disorders: None of the above	1.3	1.5	3.4	0.6	-1.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.8	-1.4	-0.2	-0.9
Emphysema/chronic bronchitis	0.9	1.0	1.9	-0.5	-0.9	-1.4
Medication for pain relief, constipation, heartburn	1.3	2.2	2.7	1.5	1.3	1.6
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.5	0.4	0.7
Medication: Blood pressure	1.3	2.2	3.4	-1.3	-1.2	-1.8
Angina (self-reported)	0.7	0.9	1.4	-0.6	-1.0	-1.2
Migraine (self-reported)	0.6	0.7	1.7	1.3	0.5	0.4
Medication: Ibuprofen	0.5	0.6	1.6	-1.3	0.5	-0.1
Medication: Allopurinol	0.9	1.2	2.0	-1.4	1.2	-0.2
Medication: Omeprazole	0.1	0.1	0.2	0.1	-0.4	0.4
Medication: Seretide 50 evohaler	1.3	1.5	1.9	-1.1	1.4	1.1
Mean time to correctly identify matches	1.8	3.4	5.4	-1.9	-1.1	-2.3
Heart disease (mother)	2.1	2.6	5.2	-0.1	-1.6	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	6.0	2.4	0.4	1.3
Whole body fat mass	2.7	11.2	17.1	-3.7	-1.6	-4.1
Leg fat mass (right)	2.8	11.0	18.1	-3.6	-1.5	-4.3
Arm predicted mass (right)	0.2	0.8	1.4	-0.8	0.7	-1.2
Pulse rate, automated reading	5.9	18.9	28.5	-2.3	-4.8	-5.3
Alcohol intake frequency.	1.9	4.5	6.9	2.6	0.8	2.4
Comparative height size at age 10	0.1	0.6	0.9	1.0	0.7	0.6
Number of full sisters	1.1	1.3	1.5	-1.2	-1.0	-1.2
Suffer from ‘nerves’	0.4	0.7	1.0	0.9	0.4	1.0
Overall health rating	2.8	6.1	9.1	-1.1	-3.0	-2.8
Chest pain or discomfort	4.5	6.5	11.2	0.1	-3.3	-2.9
Had major operations	0.1	0.2	0.5	0.1	0.2	0.7
Age at last live birth	2.6	3.7	5.8	2.4	1.4	1.8
Family relationship satisfaction	1.2	1.5	3.8	-2.0	-0.3	-0.7
Leg pain on walking	2.6	3.2	4.3	-1.5	-1.7	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	-0.9	-0.8	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.8	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.1	1.5	0.4	0.1
Medication: Aspirin	2.5	3.3	5.0	-0.7	-2.1	-2.2
Supplements: Vitamin C	0.4	0.5	1.1	0.5	-1.0	0.3
Knee pain experienced in last month	0.2	0.4	0.8	0.9	-0.5	0.2
Hypertension (Self-reported)	2.6	7.2	9.7	-1.6	-3.1	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	1.2	0.0	0.9
Illnesses of father: Heart disease	0.7	1.0	1.8	-0.2	-1.1	-1.4
Illnesses of siblings: Diabetes	0.4	0.4	0.8	0.9	-0.7	-0.2
Smoking status: Previous	4.0	6.0	8.5	-2.6	-1.7	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.4	1.5	-0.5	0.8
Whole body fat-free mass	0.1	0.8	1.1	-1.1	0.7	-0.9
Leg fat-free mass (right)	0.2	1.3	2.3	-1.5	0.2	-1.2
Arm fat percentage (left)	2.9	11.7	17.5	-3.8	-1.8	-4.2
Average weekly red wine intake	0.7	1.1	2.0	-0.6	-0.9	-1.4
Handedness (chirality/laterality): Left-handed	6.5	7.8	11.7	-2.7	-2.1	-3.4
Mood swings	0.6	1.0	1.8	-0.5	-1.4	-0.9
Loneliness, isolation	1.2	1.6	2.9	-0.4	-1.7	-1.3
Long-standing illness, disability or infirmity	0.8	1.2	2.3	1.5	0.2	1.1
Ever had bowel cancer screening	1.3	1.5	2.6	1.6	0.3	1.4
Diabetes diagnosed by doctor	2.1	3.4	4.3	-2.1	-1.5	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.2	0.6	-0.4
Friendships satisfaction	0.3	0.4	0.8	-0.2	-0.9	-0.5
Qualifications: nursing, teaching	1.1	1.7	3.8	-0.6	2.0	1.0
Commuting to job workplace: Walk	3.0	3.2	5.9	2.4	0.7	1.8
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.0	0.5	0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.6	2.1	-0.5	0.7
Medication for cholesterol	1.8	2.7	6.2	0.1	2.5	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	1.9	3.5	1.1	1.1	1.9
Back pain experienced in last month	0.3	0.4	0.9	0.9	0.4	0.4
Mineral and other dietary supplements	4.5	6.0	11.0	-1.1	-2.4	-3.3
Breast cancer (self-reported)	0.4	0.4	0.9	0.9	0.6	-0.2
Asthma (self-reported)	0.6	1.1	2.6	1.6	0.3	0.8
Osteoporosis (self-reported)	0.4	0.5	0.9	0.9	-0.3	0.7
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.0	0.2	0.2
Medication: Aspirin	3.5	4.6	7.1	-1.4	-2.2	-2.7
Medication: Gliclazide	0.0	0.0	0.0	-0.1	-0.1	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.2	0.5	-0.7	0.0	0.0
Smoking status: Current	2.1	3.3	4.8	-1.4	-2.2	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.4	1.8	0.2	1.2
Whole body water mass	0.1	0.8	1.1	-1.1	0.6	-0.9
Leg predicted mass (right)	0.3	1.4	2.4	-1.5	0.2	-1.3
Arm fat mass (left)	2.8	11.5	17.9	-3.7	-1.7	-4.2
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	-0.5	-0.4	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	0.8	-0.8	-0.9	-0.8
Miserableness	1.6	2.7	5.4	-0.5	-2.3	-1.6
Guilty feelings	2.2	3.3	3.4	-1.8	-1.8	-1.8
Wears glasses or contact lenses	0.1	0.1	0.1	-0.1	0.3	0.4
Ever taken oral contraceptive pill	0.7	0.8	1.4	-0.4	1.2	0.8
Hearing aid user	0.7	0.8	1.8	1.3	-0.4	0.6
Mother’s age at death	3.8	4.7	6.3	2.5	1.5	2.4
Financial situation satisfaction	0.9	1.1	1.7	-1.0	1.3	0.8
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	-0.3	-0.2	0.0
Commuting to job workplace: Public transport	1.9	2.3	3.8	-1.9	-1.1	-1.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	-0.3	-1.2	-1.5
Medication: Blood pressure	2.7	5.1	6.7	-1.6	-2.5	-2.6
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.0	-0.1	-1.5	-1.7
Supplements: Fish oil (including cod liver oil)	6.0	7.8	12.8	1.7	2.8	3.6
High cholesterol (Self-reported)	1.2	2.1	5.1	0.2	-2.2	-1.1
Medication: Bendroflumethiazide	0.8	1.2	1.9	-0.4	-1.2	-1.4
Medication: Paracetamol	1.3	2.0	3.6	-0.9	-1.9	-1.2
Medication: Lisinopril	2.4	3.1	4.2	-2.1	-1.6	-1.5
Medication: Atorvastatin	0.5	0.6	1.0	-0.9	1.0	0.4
Illnesses of father: High blood pressure	0.3	0.4	0.7	-0.6	-0.8	-0.3
Alcohol drinker status: Never	4.8	5.8	9.5	2.5	1.3	3.1
Ever smoked	9.2	16.2	23.8	-4.0	-2.9	-4.9
Basal metabolic rate	0.3	1.7	2.6	-1.6	0.2	-1.6
Leg fat percentage (left)	3.6	12.9	21.6	-3.7	-1.9	-4.6
Arm fat-free mass (left)	0.2	1.0	2.1	-1.0	0.2	-1.4
Number of operations (self-reported)	0.1	0.1	0.3	-0.5	0.1	-0.4
Average weekly beer plus cider intake	2.4	3.4	7.9	-0.4	-1.5	-2.8
Irritability	0.2	0.4	0.8	-0.9	0.4	-0.5
Risk taking	1.3	1.9	3.5	-1.9	1.5	0.4
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.6	1.5	1.1	1.9
Fractured/broken bones in last 5 years	4.5	5.8	10.2	1.0	2.5	3.2
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	-0.2	-0.1
Diastolic blood pressure, automated reading	3.2	10.0	17.3	-2.2	-2.8	-4.2
Ever depressed for a whole week	1.5	1.8	3.9	-2.0	-0.2	-1.2
Unable to work because of sickness or disability	0.5	0.6	0.9	0.9	-1.0	0.0
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.8	-0.1	-0.9
Myopia	1.7	2.5	3.5	1.0	1.9	1.7
Vascular/heart problems diagnosed by doctor	3.1	8.3	11.6	1.8	3.2	3.4
Cholesterol lowering medication	0.6	0.9	1.1	-1.0	-0.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	0.6	-0.1	0.8
Pain experienced in last month	0.7	1.1	2.1	-1.4	1.1	-0.3
Supplements: Calcium	6.4	7.1	10.7	1.5	2.9	3.3
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.0	0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	-0.3	0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.6	-0.3	1.9	1.5
Heart disease (siblings)	7.1	8.7	13.1	-1.6	-3.2	-3.6
Alcohol drinker status: Previous	0.3	0.4	0.7	0.3	-0.8	-0.6
Pack years of smoking	3.9	5.7	8.4	-2.9	-1.2	-2.7
Impedance of whole body	0.6	2.9	6.2	2.5	0.2	1.6
Leg fat mass (left)	3.0	11.7	18.7	-3.8	-1.5	-4.3
Arm predicted mass (left)	0.2	1.3	2.7	-1.0	0.0	-1.6