Hub : Genes

ADAP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.1070 0.055 7.6e-03 0.128 NA 0.109 NA 0.117 1.3e-04 NA 4.1e-04 NA 2.6e-04
2 GTEx Cells Transformed fibroblasts 0.1790 0.056 1.4e-09 0.199 NA 0.198 NA 0.196 6.9e-15 NA 8.7e-15 NA 1.2e-14
3 YFS Blood 0.0739 0.033 3.5e-03 0.014 0.003 0.017 NA 0.020 1.2e-05 0.023 2.6e-06 NA 3.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.3 1.9 -1.4 -0.9 1.1
Bipolar Disorder or Schizophrenia 3.0 7.4 11.7 -3.2 -3.4 -0.8
Depressed Affect (Nagel 2018) 2.0 4.2 6.6 -2.6 -2.5 0.2
Depression (Nagel 2018) 2.9 4.3 7.2 -2.7 -2.3 0.8
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.4 0.6 0.2 0.6
Neuroticism (Nagel 2018) 1.3 3.0 5.1 -2.2 -2.0 -0.2
Schizophrenia (2018) 3.7 7.7 12.7 -2.9 -3.6 -1.3
Schizophrenia vs Biploar Disorder 1.4 1.8 3.5 -1.4 -1.9 0.0
Worry (Nagel 2018) 0.9 1.9 2.9 -1.7 -1.0 -1.3
Alzheimer’s Disease (in mother) 1.4 1.6 2.6 -0.5 -1.4 -1.6
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.8 0.6 -0.6
Alzheimer’s Disease (including proxy) 0.9 1.3 3.2 -0.2 -0.7 -1.8
Crohns Disease (2017) 1.9 4.3 10.3 -1.4 -0.7 3.2
Irritable Bowel Disease (IBD) 0.9 2.2 4.9 -1.2 -0.3 2.2
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.1 0.4 0.7
Major Depression (MDD) 3.6 4.4 6.6 -2.4 -2.6 1.0
Reaction Time 3.3 6.3 10.6 -2.9 -3.2 0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.5 0.7 0.6 0.7
Breast Cancer 0.5 1.1 2.4 0.5 0.8 -1.6
Ovarian Cancer 2.9 3.9 4.5 -1.9 -2.1 1.9
Prostate Cancer 0.1 0.1 0.3 0.3 0.2 -0.6
Age at First Birth 2.9 4.1 6.1 2.2 2.5 -1.3
Bipolar Disorder (2011) 0.3 0.3 0.8 -0.9 0.2 0.0
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 0.3 0.7 -0.2
Coronary Artery Disease (CAD) 1.3 1.6 2.6 -1.3 -1.6 -0.7
Crohns Disease (2012) 0.0 0.1 0.1 -0.1 0.1 -0.4
Mean Putamen Volume 0.3 0.4 0.6 0.6 0.8 0.3
Fasting Glucose 0.2 0.2 0.5 0.0 -0.3 -0.7
HbA1C 1.7 1.9 2.8 -1.6 -1.7 -0.3
HDL Cholesterol 0.6 1.0 1.5 1.0 1.2 -0.7
LDL Cholesterol 3.4 5.4 7.7 -2.8 -2.3 1.8
Lupus 0.7 1.1 2.5 -1.6 -0.9 0.2
Neuroticism (2016) 0.9 1.3 3.2 -1.8 -0.9 0.1
Primary Biliary Cirrhosis 2.4 3.4 4.4 -2.0 -2.1 1.4
Rheumatoid Arthritis 1.2 1.7 3.8 1.9 1.0 -0.6
Schizophrenia (2014) 4.1 9.0 14.8 -3.2 -3.8 -1.3
Triglycerides 1.6 2.7 4.5 -1.8 -2.1 0.3
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.1 1.4 1.0 -0.3
Ulcerative Colitis 0.5 0.7 1.0 -0.3 -1.0 1.0
Blood Eosinophil Count 1.1 8.2 15.0 -3.1 -3.9 0.3
Blood Platelet Count 0.2 2.7 6.6 -2.6 1.2 0.3
Blood Red Count 1.4 13.0 20.8 -2.1 -4.6 3.7
Blood White Count 0.1 0.7 1.6 -1.3 -0.7 -0.3
Heel T-Score 0.4 2.9 7.3 -1.0 0.6 -2.7
BMI 0.1 0.6 1.3 0.7 1.1 -0.4
Height 0.4 8.4 23.8 4.9 1.0 -0.7
Waist Hip Ratio (WHR) 1.0 4.4 7.0 -2.2 -2.6 1.2
Systolic Blood Pressure 2.8 13.9 21.3 -4.6 -3.7 2.6
Smoking Status 1.1 2.7 4.1 -2.0 -1.9 -0.5
Allergy or Eczema 1.5 3.9 6.9 -2.6 -2.0 0.8
Cardiovascular Disease 5.2 17.3 26.6 -5.2 -4.8 1.5
Hypothyroidism (self reported) 2.0 4.7 7.2 -2.6 -2.7 -0.3
Respiratory disease 0.8 1.8 3.2 -0.6 -1.3 -1.8
Type 2 Diabetes (T2D) (2018) 1.4 2.7 4.5 -1.8 -2.1 0.4
Lung FEV1/FVC ratio 0.5 2.4 4.3 2.1 1.1 1.3
Lung FVC 0.1 0.7 1.4 -0.8 -0.3 -1.2
Neuroticism 1.3 3.1 5.8 -2.4 -1.9 0.4
Chronotype (morning person) 0.1 0.1 0.3 0.0 0.3 0.6
Hair Pigment 0.1 1.8 3.6 -1.9 -1.3 0.2
Tanning 0.1 0.6 0.8 -0.6 -0.9 -0.8
Hand grip strength (left) 0.7 2.0 4.0 0.4 1.3 2.0
Number of treatments/medications taken 2.6 4.8 7.0 -2.6 -2.6 -0.7
Average weekly spirits intake 0.3 0.4 1.0 1.0 0.4 -0.0
Sensitivity / hurt feelings 1.2 2.1 4.8 -2.2 -0.7 -0.9
Frequency of depressed mood in last 2 weeks 4.0 5.6 8.4 -2.9 -2.8 0.7
Hearing difficulty/problems: Yes 1.1 1.7 3.4 -1.1 -1.8 -0.6
Relative age of first facial hair 0.3 0.7 1.1 -1.0 -1.0 -0.0
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.4 -1.8 -1.3 0.6
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.6 -0.1 -0.7 -1.3
Ever had hysterectomy (womb removed) 8.5 9.6 13.4 -3.7 -3.5 1.9
Systolic blood pressure, automated reading 2.2 6.5 13.9 -3.7 -2.3 0.6
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 2.4 -1.5 -1.6 -0.2
Angina 0.9 1.2 2.4 -1.5 -0.8 0.8
Medication for hormone replacement therapy 0.1 0.1 0.2 0.5 -0.2 -0.3
Vitamin and mineral supplements 1.1 1.5 2.2 -1.5 -0.5 -1.4
Supplements: Zinc 0.1 0.1 0.3 0.1 -0.2 0.6
Medication: Co-codamol 0.2 0.2 0.7 0.1 0.0 -0.8
Medication: Metformin 1.0 1.5 2.7 -1.1 -1.6 0.6
Diabetes (father) 0.6 0.8 1.1 1.0 -0.4 -1.1
Diabetes (mother) 0.1 0.2 0.4 -0.2 -0.3 -0.7
Severe depression (siblings) 0.9 1.0 1.3 -1.2 -1.0 -0.8
Pack years adult smoking proportion 0.4 0.6 0.8 0.9 0.6 -0.8
Impedance of leg (right) 1.3 6.1 9.1 -2.6 -3.0 1.5
Leg fat-free mass (left) 0.9 4.5 10.8 3.3 1.6 -0.4
Trunk fat percentage 0.1 0.3 0.7 0.2 -0.8 -0.5
Hand grip strength (right) 0.7 1.8 2.3 1.3 1.5 1.3
Townsend deprivation index at recruitment 3.8 5.4 8.4 -2.2 -2.9 1.7
Current tobacco smoking 0.7 1.1 1.7 -0.5 -1.2 -1.3
Average weekly fortified wine intake 1.0 1.2 1.4 1.2 1.2 -0.9
Maternal smoking around birth 1.8 2.7 5.6 -1.5 -2.4 -0.2
Fed-up feelings 0.3 0.6 1.2 -1.1 -0.8 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 4.5 6.0 9.6 -3.1 -2.7 1.1
Relative age voice broke 0.1 0.1 0.2 0.2 -0.2 -0.5
Taking other prescription medications 0.9 1.5 2.1 -1.4 -0.9 -1.3
Age when periods started (menarche) 1.2 2.8 4.5 1.8 2.1 -0.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.8 -0.9 -0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.4 -1.2 0.9 -0.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.6 0.5 -0.3 -1.3
Qualifications: CSEs or equivalent 0.2 0.2 0.5 -0.7 0.4 0.3
Serious illness, injury or assault to yourself 1.5 1.8 2.8 -1.5 -1.7 0.7
High blood pressure 2.1 5.9 8.5 -2.9 -2.6 1.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.1 -1.0 -1.0 1.0
Multivitamins +/- minerals 0.9 1.2 2.1 1.5 0.2 1.2
Stomach or abdominal pain in last month 2.2 2.8 4.8 -1.5 -2.2 1.1
Supplements: Glucosamine 1.6 2.1 3.5 1.5 1.9 -0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.2 -0.5 -1.1 -0.6
Medication: Atenolol 1.1 1.3 3.1 -1.8 -0.9 0.4
Medication: Levothyroxine sodium 0.9 1.6 3.0 -1.3 -1.7 -0.1
Sitting height 0.1 1.0 2.3 0.0 -0.9 1.5
Chronic bronchitis/emphysema (father) 0.4 0.5 1.2 -0.3 -0.4 1.1
High blood pressure (mother) 0.4 0.5 1.0 -0.6 -0.5 1.0
Body mass index (BMI) 0.2 0.8 1.0 1.0 0.7 -0.9
Impedance of leg (left) 1.2 6.0 8.9 -2.5 -3.0 1.7
Leg predicted mass (left) 0.8 4.4 10.4 3.2 1.6 -0.5
Trunk fat mass 0.1 0.6 1.5 1.2 -0.2 -0.3
Waist circumference 0.1 0.2 0.4 0.6 -0.2 -0.4
Number of incorrect matches in round 0.1 0.2 0.4 0.6 -0.2 -0.5
Past tobacco smoking 0.8 1.4 3.7 1.9 0.4 0.6
Alcohol usually taken with meals 3.1 5.0 9.9 2.1 3.1 0.9
Nervous feelings 0.2 0.3 0.9 -0.3 -0.1 -1.0
Frequency of tenseness / restlessness in last 2 weeks 7.4 11.5 15.2 -3.5 -3.9 2.7
Hearing difficulty/problems with background noise 1.6 2.6 4.6 -2.1 -1.8 0.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 0.6 -0.1 -0.2
Had menopause 0.4 0.6 0.9 -0.8 -1.0 -0.1
Had other major operations 0.4 0.5 1.5 0.1 -1.2 0.3
Forced vital capacity (FVC) 0.1 0.5 1.1 1.0 0.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.9 -0.7 0.8 -1.4
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 3.2 -1.3 -1.5 -1.8
Qualifications: None of the above 2.6 5.5 8.3 -2.3 -2.9 -1.7
Financial difficulties in last 2 years 0.7 0.9 2.1 -0.7 -1.4 0.4
Mouth/teeth dental problems 5.8 8.9 16.0 4.0 3.2 -0.8
Heart attack 0.0 0.0 0.1 -0.3 0.1 -0.1
Allergy 0.8 1.8 3.1 1.8 1.5 -0.4
Pain all over the body in last month 1.7 1.8 3.4 -0.4 -1.8 -1.4
Diabetes (self-reported) 1.6 2.4 4.0 -1.5 -2.0 1.0
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 2.3 1.5 1.5 -0.3
Medication: Ramipril 0.3 0.4 0.8 0.1 -0.5 0.9
Medication: Simvastatin 4.5 6.5 11.5 -3.4 -2.7 -1.0
Fluid intelligence score 0.3 0.6 1.1 1.0 0.7 0.4
Illnesses of siblings 1.4 2.0 3.2 1.8 1.5 -0.6
Neuroticism score 1.6 3.4 7.0 -2.7 -1.8 0.1
Weight 0.5 2.5 6.8 2.6 0.9 -0.1
Impedance of arm (right) 0.1 0.4 1.0 -0.4 -1.0 0.1
Arm fat percentage (right) 0.3 1.1 2.0 1.4 0.7 -0.9
Trunk fat-free mass 0.8 4.4 11.0 3.3 1.4 0.4
Hip circumference 0.6 2.6 4.2 2.1 1.3 -1.4
Time employed in main current job 0.4 0.4 0.8 0.1 -0.7 -0.9
Alcohol intake versus 10 years previously 2.4 3.7 6.5 -1.6 -2.5 1.4
Father’s age at death 2.3 3.1 4.8 2.1 2.2 -0.4
Worrier / anxious feelings 0.4 0.8 2.5 0.0 0.2 -1.6
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 4.9 -2.1 -2.2 0.4
Falls in the last year 0.6 0.8 1.4 1.2 0.9 -0.2
Hair/balding pattern: Pattern 3 0.3 0.4 0.7 -0.6 0.8 0.5
Number of live births 0.8 1.1 1.4 -1.2 -1.0 -1.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.4 1.6 0.3 1.2
Pulse rate 0.6 0.9 1.2 -0.9 -1.1 0.9
Happiness 1.0 1.2 2.0 -1.4 -1.3 -0.0
Noisy workplace 0.8 1.0 1.7 -1.1 -1.3 0.2
Qualifications: A levels/AS levels or equivalent 4.4 9.8 14.5 3.7 3.8 0.9
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 4.2 2.0 0.2 -0.3
Mouth/teeth dental problems: Dentures 3.7 6.2 9.2 -3.0 -3.0 0.4
Asthma 0.7 1.5 2.7 -0.9 -1.0 -1.6
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.1 8.1 -0.6 -0.9 2.9
Medication: Cholesterol lowering 4.5 7.1 15.1 -3.9 -2.4 0.3
Depression (self-reported) 0.9 1.1 2.4 -1.6 -0.8 0.4
Medication: Lansoprazole 1.8 2.0 3.5 -1.4 -1.9 -0.7
Prospective memory result 0.1 0.1 0.2 0.0 -0.3 -0.4
Lung cancer (father) 0.3 0.4 0.9 0.2 -0.4 0.9
Illnesses of mother 0.7 0.8 1.4 0.6 1.2 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 3.6 1.9 0.3 1.4
Pulse wave Arterial Stiffness index 1.3 1.5 2.4 1.0 1.0 1.6
Impedance of arm (left) 0.1 0.5 1.2 -0.4 -1.1 0.4
Arm fat mass (right) 0.5 2.0 4.6 2.1 0.9 -0.7
Trunk predicted mass 0.8 4.4 11.1 3.3 1.4 0.3
Standing height 0.5 4.9 12.3 3.5 0.5 1.4
Length of working week for main job 0.1 0.1 0.2 -0.4 -0.4 0.2
Exposure to tobacco smoke at home 3.4 3.8 5.6 -2.2 -2.4 0.8
Breastfed as a baby 1.3 1.6 4.1 -0.1 -0.8 2.0
Tense / ‘highly strung’ 1.1 1.8 2.1 -1.2 -1.4 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.5 -0.1 -0.4 -0.7
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 -0.3 0.2 0.1
Birth weight of first child 0.8 1.5 3.6 1.9 1.0 -0.1
Peak expiratory flow (PEF) 2.0 4.6 5.1 2.2 1.9 2.2
Pulse wave reflection index 3.1 3.8 4.4 2.1 1.9 1.8
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.2 -0.2 -1.1 0.4
Loud music exposure frequency 0.8 0.8 2.4 -0.4 -0.0 1.5
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 5.8 2.4 1.4 0.3
Mouth/teeth dental problems: Bleeding gums 1.7 2.1 4.0 -2.0 -1.1 -1.1
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.7 -0.2 -0.5
Medication: Paracetamol 1.1 1.9 2.8 -1.7 -1.6 -0.6
Headache pain in last month 2.2 3.8 7.1 -1.9 -2.7 0.8
Medication for cholesterol, blood pressure or diabetes 3.7 6.2 13.8 3.7 2.2 -0.0
Glaucoma (self-reported) 0.0 0.0 0.1 -0.3 0.1 0.1
Gout (self-reported) 0.9 1.2 2.3 -1.5 -1.1 -0.1
Hypothyroidism/myxoedema (self-reported) 1.7 3.3 5.9 -2.0 -2.4 -0.4
Medication: Amlodipine 0.2 0.3 0.9 -0.1 -0.2 0.9
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.3 -0.7 -0.3 -1.1
Birth weight 1.4 3.0 5.8 2.4 1.8 0.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.5 0.5 -0.7 0.5
High blood pressure (siblings) 1.3 1.9 2.8 -1.6 -1.7 0.5
Forced vital capacity (FVC), Best measure 0.2 0.6 1.2 1.1 0.0 0.7
Body fat percentage 0.1 0.3 0.5 0.4 -0.4 -0.7
Leg fat percentage (right) 0.1 0.2 0.6 0.3 -0.3 -0.8
Arm fat-free mass (right) 0.5 2.5 6.8 2.6 0.7 0.5
Exposure to tobacco smoke outside home 3.2 4.3 9.2 -1.6 -3.0 1.1
Comparative body size at age 10 1.7 4.6 5.5 1.9 2.1 -2.3
Number of full brothers 1.0 1.3 3.4 -0.6 -1.8 0.3
Worry too long after embarrassment 1.8 3.0 4.5 -2.1 -2.1 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 3.0 4.4 -2.0 -2.1 -0.6
Wheeze or whistling in the chest in last year 0.6 1.1 1.8 -0.6 -1.3 -1.0
Number of children fathered 0.3 0.4 0.7 0.2 0.8 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.3 -1.4 -1.8 1.2
Age at first live birth 3.2 5.6 8.6 2.8 2.9 0.5
Pulse wave peak to peak time 0.9 1.0 1.8 -0.7 -0.9 -1.3
Health satisfaction 3.4 4.4 8.0 -2.8 -2.0 -1.1
Shortness of breath walking on level ground 3.1 3.7 6.1 -2.5 -1.7 -1.5
Qualifications: College or University degree 2.2 7.1 11.3 3.1 3.4 0.7
Eye problems/disorders: None of the above 1.2 1.4 3.0 1.7 0.9 0.7
Mouth/teeth dental problems: Loose teeth 0.4 0.4 0.6 -0.8 -0.8 -0.3
Emphysema/chronic bronchitis 0.6 0.6 1.0 -1.0 -0.9 -0.4
Medication for pain relief, constipation, heartburn 3.5 5.9 8.4 2.9 2.7 -1.4
Neck or shoulder pain in last month 4.1 5.9 7.7 -2.2 -2.2 2.8
Medication: Blood pressure 1.6 2.9 6.4 -2.5 -1.3 0.8
Angina (self-reported) 0.9 1.2 2.8 -1.7 -0.8 0.4
Migraine (self-reported) 0.3 0.3 0.4 0.5 -0.6 0.6
Medication: Ibuprofen 2.3 2.8 4.1 -1.2 -1.7 2.0
Medication: Allopurinol 0.5 0.6 1.8 -1.4 -0.3 -0.2
Medication: Omeprazole 1.0 1.2 2.1 -1.4 -1.3 -0.0
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.2 0.2 0.6
Mean time to correctly identify matches 1.0 1.9 3.0 -1.6 -1.7 -0.3
Heart disease (mother) 0.7 0.9 2.1 0.5 0.6 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.0 -0.4 -0.0 1.0
Whole body fat mass 0.2 0.8 2.2 1.5 0.2 -0.6
Leg fat mass (right) 0.2 0.7 1.7 1.3 0.2 -0.5
Arm predicted mass (right) 0.4 2.2 6.0 2.4 0.5 0.6
Pulse rate, automated reading 0.1 0.3 0.4 -0.3 -0.7 0.6
Alcohol intake frequency. 1.2 2.8 4.5 -2.1 -1.7 -1.0
Comparative height size at age 10 0.4 2.1 5.2 2.3 1.0 0.4
Number of full sisters 1.6 1.9 3.8 -1.2 -1.9 0.7
Suffer from ‘nerves’ 0.8 1.2 2.4 -1.6 -0.9 0.6
Overall health rating 5.6 11.9 18.1 -4.2 -4.2 -0.4
Chest pain or discomfort 2.2 3.2 6.1 -1.6 -2.5 1.0
Had major operations 2.5 2.9 5.0 1.7 2.2 -0.8
Age at last live birth 0.7 0.9 2.0 0.9 1.4 -0.2
Family relationship satisfaction 2.2 2.8 3.8 -1.1 -2.0 -1.8
Leg pain on walking 2.2 2.8 4.2 -1.8 -0.9 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 2.2 -1.5 -0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.4 -0.1 0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 0.0 1.1 0.5
Medication: Aspirin 0.6 0.7 1.3 -1.2 -0.8 0.5
Supplements: Vitamin C 0.0 0.0 0.1 0.2 0.1 0.2
Knee pain experienced in last month 0.2 0.3 0.5 -0.4 -0.7 0.4
Hypertension (Self-reported) 2.3 6.3 8.6 -2.9 -2.7 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 5.5 -2.4 -1.9 0.4
Illnesses of father: Heart disease 0.3 0.4 0.6 0.6 0.3 -0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.1 0.4 0.3 -0.0
Smoking status: Previous 0.5 0.8 2.3 -1.5 -0.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 7.0 1.0 -0.4 2.6
Whole body fat-free mass 0.8 4.4 11.2 3.3 1.4 0.1
Leg fat-free mass (right) 0.9 4.9 11.5 3.4 1.8 -0.4
Arm fat percentage (left) 0.2 1.0 1.9 1.4 0.7 -0.8
Average weekly red wine intake 0.2 0.3 0.6 0.8 -0.1 0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.1 -1.1 0.9 -0.2
Mood swings 2.3 4.2 8.6 -2.0 -2.9 0.1
Loneliness, isolation 1.9 2.6 5.2 -2.3 -1.6 0.1
Long-standing illness, disability or infirmity 3.7 5.6 10.9 -3.3 -2.5 -0.1
Ever had bowel cancer screening 0.9 1.1 2.3 1.5 0.9 0.3
Diabetes diagnosed by doctor 0.6 1.0 1.5 -1.2 -1.1 0.6
Ever had stillbirth, spontaneous miscarriage or termination 3.4 3.6 5.2 -2.3 -1.9 1.4
Friendships satisfaction 0.3 0.4 0.9 -0.6 -0.9 -0.1
Qualifications: nursing, teaching 1.8 2.8 5.4 1.7 2.3 -0.4
Commuting to job workplace: Walk 0.5 0.5 0.8 -0.5 -0.7 0.9
Eye problems/disorders: Cataract 0.6 0.7 1.5 0.6 1.2 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.7 -1.3 -0.9 -0.5
Medication for cholesterol 1.0 1.6 3.0 1.0 1.7 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 -0.2 -0.2 0.8
Back pain experienced in last month 1.6 2.3 5.7 -2.4 -1.0 0.1
Mineral and other dietary supplements 0.1 0.1 0.3 -0.1 -0.2 -0.6
Breast cancer (self-reported) 1.9 2.2 3.4 1.5 1.1 -1.9
Asthma (self-reported) 0.9 1.8 2.9 -1.2 -1.1 -1.7
Osteoporosis (self-reported) 0.9 1.1 1.9 1.4 0.8 -0.9
Osteoarthritis (self-reported) 1.5 1.9 2.3 -1.4 -1.2 -1.5
Medication: Aspirin 0.7 0.9 1.8 -1.3 -0.9 0.3
Medication: Gliclazide 0.6 0.7 1.6 -0.1 0.7 -1.2
Illnesses of father: None of the above (group 1) 0.8 1.0 1.6 -0.9 -0.7 1.3
Smoking status: Current 0.7 1.1 1.6 -0.6 -1.3 -1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.5 0.3 -0.3
Whole body water mass 0.8 4.6 11.5 3.4 1.5 0.1
Leg predicted mass (right) 1.0 5.1 11.9 3.5 1.8 -0.3
Arm fat mass (left) 0.4 1.5 3.6 1.9 0.6 -0.7
Number of self-reported non-cancer illnesses 0.9 1.5 2.3 -1.5 -1.4 0.5
Average weekly champagne plus white wine intake 1.6 2.2 3.2 1.8 1.8 0.4
Miserableness 3.0 5.3 8.3 -2.7 -2.9 0.6
Guilty feelings 1.7 2.5 4.1 -2.0 -1.7 0.6
Wears glasses or contact lenses 0.9 1.0 2.2 -0.7 0.5 -1.5
Ever taken oral contraceptive pill 4.2 4.7 10.2 0.7 1.9 3.2
Hearing aid user 1.2 1.3 1.9 -1.0 -1.4 1.1
Mother’s age at death 0.5 0.6 1.5 -0.5 0.3 -1.2
Financial situation satisfaction 1.7 2.1 4.0 -2.0 -1.5 0.2
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.1 -0.8 -1.1 0.4
Commuting to job workplace: Public transport 0.2 0.2 0.6 -0.4 -0.7 -0.2
Eye problems/disorders: Glaucoma 0.2 0.2 0.2 -0.5 -0.4 -0.3
Medication: Blood pressure 1.4 2.6 6.1 -1.0 -2.5 0.9
Pain type(s) experienced in last month: Hip pain 1.5 1.9 2.8 -1.7 -1.5 0.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.0 0.8 1.0 -1.0
High cholesterol (Self-reported) 2.2 3.9 8.3 -2.9 -1.8 0.0
Medication: Bendroflumethiazide 0.5 0.7 1.3 -0.7 -1.1 0.6
Medication: Paracetamol 1.4 2.2 4.1 -2.0 -1.4 -0.7
Medication: Lisinopril 0.1 0.1 0.2 -0.2 0.5 -0.3
Medication: Atorvastatin 0.7 0.9 2.7 0.1 0.0 1.6
Illnesses of father: High blood pressure 0.7 0.8 1.4 0.9 1.2 -0.4
Alcohol drinker status: Never 1.9 2.3 5.3 -2.3 -1.1 -0.7
Ever smoked 0.2 0.4 0.6 -0.8 0.4 -0.6
Basal metabolic rate 0.7 4.1 10.4 3.2 1.4 0.0
Leg fat percentage (left) 0.1 0.3 0.6 0.4 -0.1 -0.8
Arm fat-free mass (left) 0.5 2.4 6.7 2.6 0.6 -0.3
Number of operations (self-reported) 1.9 2.9 4.4 2.1 1.7 1.2
Average weekly beer plus cider intake 1.6 2.3 5.1 -1.3 -2.3 -0.5
Irritability 0.9 1.5 2.1 -1.1 -1.4 1.1
Risk taking 1.7 2.5 5.4 -1.0 -2.3 1.0
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.1 0.4 -0.4
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.8 0.7 -0.1
Age started oral contraceptive pill 1.1 1.4 3.8 0.5 0.3 -2.0
Diastolic blood pressure, automated reading 0.8 2.4 2.6 -1.6 -1.4 1.6
Ever depressed for a whole week 1.4 1.8 4.2 -0.8 -0.7 -2.0
Unable to work because of sickness or disability 3.2 4.2 8.0 -2.1 -2.8 -0.0
Commuting to job workplace: Cycle 2.4 2.8 4.1 1.8 1.1 2.0
Myopia 2.1 3.1 5.2 2.3 2.0 -0.4
Vascular/heart problems diagnosed by doctor 1.9 5.2 8.2 2.9 2.3 -1.4
Cholesterol lowering medication 0.2 0.2 0.4 -0.2 -0.7 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.0 -1.4 -1.2 -0.2
Pain experienced in last month 5.7 9.5 14.5 3.6 3.8 -1.0
Supplements: Calcium 0.3 0.3 0.6 -0.5 -0.5 -0.8
Basal cell carcinoma (self-reported) 0.3 0.3 0.8 -0.3 0.4 -0.9
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 -0.3 0.2 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.1 -1.1 -0.5 -0.4
Heart disease (siblings) 1.4 1.8 4.3 -2.1 -1.0 -0.2
Alcohol drinker status: Previous 1.4 1.6 2.9 -1.3 -1.7 0.1
Pack years of smoking 0.4 0.6 0.8 0.8 0.6 -0.9
Impedance of whole body 0.6 2.9 5.2 -1.7 -2.3 0.8
Leg fat mass (left) 0.2 0.8 2.1 1.4 0.3 -0.5
Arm predicted mass (left) 0.4 1.8 5.3 2.3 0.3 -0.1