Hub : Genes

ADAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1070	0.055	7.6e-03	0.128	NA	0.109	NA	0.117	1.3e-04	NA	4.1e-04	NA	2.6e-04
2	GTEx	Cells Transformed fibroblasts	0.1790	0.056	1.4e-09	0.199	NA	0.198	NA	0.196	6.9e-15	NA	8.7e-15	NA	1.2e-14
3	YFS	Blood	0.0739	0.033	3.5e-03	0.014	0.003	0.017	NA	0.020	1.2e-05	0.023	2.6e-06	NA	3.5e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	1.9	-1.4	-0.9	1.1
Bipolar Disorder or Schizophrenia	3.0	7.4	11.7	-3.2	-3.4	-0.8
Depressed Affect (Nagel 2018)	2.0	4.2	6.6	-2.6	-2.5	0.2
Depression (Nagel 2018)	2.9	4.3	7.2	-2.7	-2.3	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	0.6	0.2	0.6
Neuroticism (Nagel 2018)	1.3	3.0	5.1	-2.2	-2.0	-0.2
Schizophrenia (2018)	3.7	7.7	12.7	-2.9	-3.6	-1.3
Schizophrenia vs Biploar Disorder	1.4	1.8	3.5	-1.4	-1.9	0.0
Worry (Nagel 2018)	0.9	1.9	2.9	-1.7	-1.0	-1.3
Alzheimer’s Disease (in mother)	1.4	1.6	2.6	-0.5	-1.4	-1.6
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.8	0.6	-0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	3.2	-0.2	-0.7	-1.8
Crohns Disease (2017)	1.9	4.3	10.3	-1.4	-0.7	3.2
Irritable Bowel Disease (IBD)	0.9	2.2	4.9	-1.2	-0.3	2.2
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.1	0.4	0.7
Major Depression (MDD)	3.6	4.4	6.6	-2.4	-2.6	1.0
Reaction Time	3.3	6.3	10.6	-2.9	-3.2	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.5	0.7	0.6	0.7
Breast Cancer	0.5	1.1	2.4	0.5	0.8	-1.6
Ovarian Cancer	2.9	3.9	4.5	-1.9	-2.1	1.9
Prostate Cancer	0.1	0.1	0.3	0.3	0.2	-0.6
Age at First Birth	2.9	4.1	6.1	2.2	2.5	-1.3
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.9	0.2	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.3	0.7	-0.2
Coronary Artery Disease (CAD)	1.3	1.6	2.6	-1.3	-1.6	-0.7
Crohns Disease (2012)	0.0	0.1	0.1	-0.1	0.1	-0.4
Mean Putamen Volume	0.3	0.4	0.6	0.6	0.8	0.3
Fasting Glucose	0.2	0.2	0.5	0.0	-0.3	-0.7
HbA1C	1.7	1.9	2.8	-1.6	-1.7	-0.3
HDL Cholesterol	0.6	1.0	1.5	1.0	1.2	-0.7
LDL Cholesterol	3.4	5.4	7.7	-2.8	-2.3	1.8
Lupus	0.7	1.1	2.5	-1.6	-0.9	0.2
Neuroticism (2016)	0.9	1.3	3.2	-1.8	-0.9	0.1
Primary Biliary Cirrhosis	2.4	3.4	4.4	-2.0	-2.1	1.4
Rheumatoid Arthritis	1.2	1.7	3.8	1.9	1.0	-0.6
Schizophrenia (2014)	4.1	9.0	14.8	-3.2	-3.8	-1.3
Triglycerides	1.6	2.7	4.5	-1.8	-2.1	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.1	1.4	1.0	-0.3
Ulcerative Colitis	0.5	0.7	1.0	-0.3	-1.0	1.0
Blood Eosinophil Count	1.1	8.2	15.0	-3.1	-3.9	0.3
Blood Platelet Count	0.2	2.7	6.6	-2.6	1.2	0.3
Blood Red Count	1.4	13.0	20.8	-2.1	-4.6	3.7
Blood White Count	0.1	0.7	1.6	-1.3	-0.7	-0.3
Heel T-Score	0.4	2.9	7.3	-1.0	0.6	-2.7
BMI	0.1	0.6	1.3	0.7	1.1	-0.4
Height	0.4	8.4	23.8	4.9	1.0	-0.7
Waist Hip Ratio (WHR)	1.0	4.4	7.0	-2.2	-2.6	1.2
Systolic Blood Pressure	2.8	13.9	21.3	-4.6	-3.7	2.6
Smoking Status	1.1	2.7	4.1	-2.0	-1.9	-0.5
Allergy or Eczema	1.5	3.9	6.9	-2.6	-2.0	0.8
Cardiovascular Disease	5.2	17.3	26.6	-5.2	-4.8	1.5
Hypothyroidism (self reported)	2.0	4.7	7.2	-2.6	-2.7	-0.3
Respiratory disease	0.8	1.8	3.2	-0.6	-1.3	-1.8
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.5	-1.8	-2.1	0.4
Lung FEV1/FVC ratio	0.5	2.4	4.3	2.1	1.1	1.3
Lung FVC	0.1	0.7	1.4	-0.8	-0.3	-1.2
Neuroticism	1.3	3.1	5.8	-2.4	-1.9	0.4
Chronotype (morning person)	0.1	0.1	0.3	0.0	0.3	0.6
Hair Pigment	0.1	1.8	3.6	-1.9	-1.3	0.2
Tanning	0.1	0.6	0.8	-0.6	-0.9	-0.8
Hand grip strength (left)	0.7	2.0	4.0	0.4	1.3	2.0
Number of treatments/medications taken	2.6	4.8	7.0	-2.6	-2.6	-0.7
Average weekly spirits intake	0.3	0.4	1.0	1.0	0.4	-0.0
Sensitivity / hurt feelings	1.2	2.1	4.8	-2.2	-0.7	-0.9
Frequency of depressed mood in last 2 weeks	4.0	5.6	8.4	-2.9	-2.8	0.7
Hearing difficulty/problems: Yes	1.1	1.7	3.4	-1.1	-1.8	-0.6
Relative age of first facial hair	0.3	0.7	1.1	-1.0	-1.0	-0.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.4	-1.8	-1.3	0.6
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.6	-0.1	-0.7	-1.3
Ever had hysterectomy (womb removed)	8.5	9.6	13.4	-3.7	-3.5	1.9
Systolic blood pressure, automated reading	2.2	6.5	13.9	-3.7	-2.3	0.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	2.4	-1.5	-1.6	-0.2
Angina	0.9	1.2	2.4	-1.5	-0.8	0.8
Medication for hormone replacement therapy	0.1	0.1	0.2	0.5	-0.2	-0.3
Vitamin and mineral supplements	1.1	1.5	2.2	-1.5	-0.5	-1.4
Supplements: Zinc	0.1	0.1	0.3	0.1	-0.2	0.6
Medication: Co-codamol	0.2	0.2	0.7	0.1	0.0	-0.8
Medication: Metformin	1.0	1.5	2.7	-1.1	-1.6	0.6
Diabetes (father)	0.6	0.8	1.1	1.0	-0.4	-1.1
Diabetes (mother)	0.1	0.2	0.4	-0.2	-0.3	-0.7
Severe depression (siblings)	0.9	1.0	1.3	-1.2	-1.0	-0.8
Pack years adult smoking proportion	0.4	0.6	0.8	0.9	0.6	-0.8
Impedance of leg (right)	1.3	6.1	9.1	-2.6	-3.0	1.5
Leg fat-free mass (left)	0.9	4.5	10.8	3.3	1.6	-0.4
Trunk fat percentage	0.1	0.3	0.7	0.2	-0.8	-0.5
Hand grip strength (right)	0.7	1.8	2.3	1.3	1.5	1.3
Townsend deprivation index at recruitment	3.8	5.4	8.4	-2.2	-2.9	1.7
Current tobacco smoking	0.7	1.1	1.7	-0.5	-1.2	-1.3
Average weekly fortified wine intake	1.0	1.2	1.4	1.2	1.2	-0.9
Maternal smoking around birth	1.8	2.7	5.6	-1.5	-2.4	-0.2
Fed-up feelings	0.3	0.6	1.2	-1.1	-0.8	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	4.5	6.0	9.6	-3.1	-2.7	1.1
Relative age voice broke	0.1	0.1	0.2	0.2	-0.2	-0.5
Taking other prescription medications	0.9	1.5	2.1	-1.4	-0.9	-1.3
Age when periods started (menarche)	1.2	2.8	4.5	1.8	2.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.8	-0.9	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.4	-1.2	0.9	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	0.5	-0.3	-1.3
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.7	0.4	0.3
Serious illness, injury or assault to yourself	1.5	1.8	2.8	-1.5	-1.7	0.7
High blood pressure	2.1	5.9	8.5	-2.9	-2.6	1.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.1	-1.0	-1.0	1.0
Multivitamins +/- minerals	0.9	1.2	2.1	1.5	0.2	1.2
Stomach or abdominal pain in last month	2.2	2.8	4.8	-1.5	-2.2	1.1
Supplements: Glucosamine	1.6	2.1	3.5	1.5	1.9	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.5	-1.1	-0.6
Medication: Atenolol	1.1	1.3	3.1	-1.8	-0.9	0.4
Medication: Levothyroxine sodium	0.9	1.6	3.0	-1.3	-1.7	-0.1
Sitting height	0.1	1.0	2.3	0.0	-0.9	1.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-0.3	-0.4	1.1
High blood pressure (mother)	0.4	0.5	1.0	-0.6	-0.5	1.0
Body mass index (BMI)	0.2	0.8	1.0	1.0	0.7	-0.9
Impedance of leg (left)	1.2	6.0	8.9	-2.5	-3.0	1.7
Leg predicted mass (left)	0.8	4.4	10.4	3.2	1.6	-0.5
Trunk fat mass	0.1	0.6	1.5	1.2	-0.2	-0.3
Waist circumference	0.1	0.2	0.4	0.6	-0.2	-0.4
Number of incorrect matches in round	0.1	0.2	0.4	0.6	-0.2	-0.5
Past tobacco smoking	0.8	1.4	3.7	1.9	0.4	0.6
Alcohol usually taken with meals	3.1	5.0	9.9	2.1	3.1	0.9
Nervous feelings	0.2	0.3	0.9	-0.3	-0.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	7.4	11.5	15.2	-3.5	-3.9	2.7
Hearing difficulty/problems with background noise	1.6	2.6	4.6	-2.1	-1.8	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.6	-0.1	-0.2
Had menopause	0.4	0.6	0.9	-0.8	-1.0	-0.1
Had other major operations	0.4	0.5	1.5	0.1	-1.2	0.3
Forced vital capacity (FVC)	0.1	0.5	1.1	1.0	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.9	-0.7	0.8	-1.4
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	3.2	-1.3	-1.5	-1.8
Qualifications: None of the above	2.6	5.5	8.3	-2.3	-2.9	-1.7
Financial difficulties in last 2 years	0.7	0.9	2.1	-0.7	-1.4	0.4
Mouth/teeth dental problems	5.8	8.9	16.0	4.0	3.2	-0.8
Heart attack	0.0	0.0	0.1	-0.3	0.1	-0.1
Allergy	0.8	1.8	3.1	1.8	1.5	-0.4
Pain all over the body in last month	1.7	1.8	3.4	-0.4	-1.8	-1.4
Diabetes (self-reported)	1.6	2.4	4.0	-1.5	-2.0	1.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.3	1.5	1.5	-0.3
Medication: Ramipril	0.3	0.4	0.8	0.1	-0.5	0.9
Medication: Simvastatin	4.5	6.5	11.5	-3.4	-2.7	-1.0
Fluid intelligence score	0.3	0.6	1.1	1.0	0.7	0.4
Illnesses of siblings	1.4	2.0	3.2	1.8	1.5	-0.6
Neuroticism score	1.6	3.4	7.0	-2.7	-1.8	0.1
Weight	0.5	2.5	6.8	2.6	0.9	-0.1
Impedance of arm (right)	0.1	0.4	1.0	-0.4	-1.0	0.1
Arm fat percentage (right)	0.3	1.1	2.0	1.4	0.7	-0.9
Trunk fat-free mass	0.8	4.4	11.0	3.3	1.4	0.4
Hip circumference	0.6	2.6	4.2	2.1	1.3	-1.4
Time employed in main current job	0.4	0.4	0.8	0.1	-0.7	-0.9
Alcohol intake versus 10 years previously	2.4	3.7	6.5	-1.6	-2.5	1.4
Father’s age at death	2.3	3.1	4.8	2.1	2.2	-0.4
Worrier / anxious feelings	0.4	0.8	2.5	0.0	0.2	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.9	-2.1	-2.2	0.4
Falls in the last year	0.6	0.8	1.4	1.2	0.9	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.6	0.8	0.5
Number of live births	0.8	1.1	1.4	-1.2	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	1.6	0.3	1.2
Pulse rate	0.6	0.9	1.2	-0.9	-1.1	0.9
Happiness	1.0	1.2	2.0	-1.4	-1.3	-0.0
Noisy workplace	0.8	1.0	1.7	-1.1	-1.3	0.2
Qualifications: A levels/AS levels or equivalent	4.4	9.8	14.5	3.7	3.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.2	2.0	0.2	-0.3
Mouth/teeth dental problems: Dentures	3.7	6.2	9.2	-3.0	-3.0	0.4
Asthma	0.7	1.5	2.7	-0.9	-1.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.1	8.1	-0.6	-0.9	2.9
Medication: Cholesterol lowering	4.5	7.1	15.1	-3.9	-2.4	0.3
Depression (self-reported)	0.9	1.1	2.4	-1.6	-0.8	0.4
Medication: Lansoprazole	1.8	2.0	3.5	-1.4	-1.9	-0.7
Prospective memory result	0.1	0.1	0.2	0.0	-0.3	-0.4
Lung cancer (father)	0.3	0.4	0.9	0.2	-0.4	0.9
Illnesses of mother	0.7	0.8	1.4	0.6	1.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.6	1.9	0.3	1.4
Pulse wave Arterial Stiffness index	1.3	1.5	2.4	1.0	1.0	1.6
Impedance of arm (left)	0.1	0.5	1.2	-0.4	-1.1	0.4
Arm fat mass (right)	0.5	2.0	4.6	2.1	0.9	-0.7
Trunk predicted mass	0.8	4.4	11.1	3.3	1.4	0.3
Standing height	0.5	4.9	12.3	3.5	0.5	1.4
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.4	0.2
Exposure to tobacco smoke at home	3.4	3.8	5.6	-2.2	-2.4	0.8
Breastfed as a baby	1.3	1.6	4.1	-0.1	-0.8	2.0
Tense / ‘highly strung’	1.1	1.8	2.1	-1.2	-1.4	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.1	-0.4	-0.7
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.3	0.2	0.1
Birth weight of first child	0.8	1.5	3.6	1.9	1.0	-0.1
Peak expiratory flow (PEF)	2.0	4.6	5.1	2.2	1.9	2.2
Pulse wave reflection index	3.1	3.8	4.4	2.1	1.9	1.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.2	-1.1	0.4
Loud music exposure frequency	0.8	0.8	2.4	-0.4	-0.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	5.8	2.4	1.4	0.3
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	4.0	-2.0	-1.1	-1.1
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.7	-0.2	-0.5
Medication: Paracetamol	1.1	1.9	2.8	-1.7	-1.6	-0.6
Headache pain in last month	2.2	3.8	7.1	-1.9	-2.7	0.8
Medication for cholesterol, blood pressure or diabetes	3.7	6.2	13.8	3.7	2.2	-0.0
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	0.1	0.1
Gout (self-reported)	0.9	1.2	2.3	-1.5	-1.1	-0.1
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	5.9	-2.0	-2.4	-0.4
Medication: Amlodipine	0.2	0.3	0.9	-0.1	-0.2	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	-0.7	-0.3	-1.1
Birth weight	1.4	3.0	5.8	2.4	1.8	0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.5	-0.7	0.5
High blood pressure (siblings)	1.3	1.9	2.8	-1.6	-1.7	0.5
Forced vital capacity (FVC), Best measure	0.2	0.6	1.2	1.1	0.0	0.7
Body fat percentage	0.1	0.3	0.5	0.4	-0.4	-0.7
Leg fat percentage (right)	0.1	0.2	0.6	0.3	-0.3	-0.8
Arm fat-free mass (right)	0.5	2.5	6.8	2.6	0.7	0.5
Exposure to tobacco smoke outside home	3.2	4.3	9.2	-1.6	-3.0	1.1
Comparative body size at age 10	1.7	4.6	5.5	1.9	2.1	-2.3
Number of full brothers	1.0	1.3	3.4	-0.6	-1.8	0.3
Worry too long after embarrassment	1.8	3.0	4.5	-2.1	-2.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	4.4	-2.0	-2.1	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	1.8	-0.6	-1.3	-1.0
Number of children fathered	0.3	0.4	0.7	0.2	0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.3	-1.4	-1.8	1.2
Age at first live birth	3.2	5.6	8.6	2.8	2.9	0.5
Pulse wave peak to peak time	0.9	1.0	1.8	-0.7	-0.9	-1.3
Health satisfaction	3.4	4.4	8.0	-2.8	-2.0	-1.1
Shortness of breath walking on level ground	3.1	3.7	6.1	-2.5	-1.7	-1.5
Qualifications: College or University degree	2.2	7.1	11.3	3.1	3.4	0.7
Eye problems/disorders: None of the above	1.2	1.4	3.0	1.7	0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.6	-0.8	-0.8	-0.3
Emphysema/chronic bronchitis	0.6	0.6	1.0	-1.0	-0.9	-0.4
Medication for pain relief, constipation, heartburn	3.5	5.9	8.4	2.9	2.7	-1.4
Neck or shoulder pain in last month	4.1	5.9	7.7	-2.2	-2.2	2.8
Medication: Blood pressure	1.6	2.9	6.4	-2.5	-1.3	0.8
Angina (self-reported)	0.9	1.2	2.8	-1.7	-0.8	0.4
Migraine (self-reported)	0.3	0.3	0.4	0.5	-0.6	0.6
Medication: Ibuprofen	2.3	2.8	4.1	-1.2	-1.7	2.0
Medication: Allopurinol	0.5	0.6	1.8	-1.4	-0.3	-0.2
Medication: Omeprazole	1.0	1.2	2.1	-1.4	-1.3	-0.0
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.2	0.2	0.6
Mean time to correctly identify matches	1.0	1.9	3.0	-1.6	-1.7	-0.3
Heart disease (mother)	0.7	0.9	2.1	0.5	0.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	-0.4	-0.0	1.0
Whole body fat mass	0.2	0.8	2.2	1.5	0.2	-0.6
Leg fat mass (right)	0.2	0.7	1.7	1.3	0.2	-0.5
Arm predicted mass (right)	0.4	2.2	6.0	2.4	0.5	0.6
Pulse rate, automated reading	0.1	0.3	0.4	-0.3	-0.7	0.6
Alcohol intake frequency.	1.2	2.8	4.5	-2.1	-1.7	-1.0
Comparative height size at age 10	0.4	2.1	5.2	2.3	1.0	0.4
Number of full sisters	1.6	1.9	3.8	-1.2	-1.9	0.7
Suffer from ‘nerves’	0.8	1.2	2.4	-1.6	-0.9	0.6
Overall health rating	5.6	11.9	18.1	-4.2	-4.2	-0.4
Chest pain or discomfort	2.2	3.2	6.1	-1.6	-2.5	1.0
Had major operations	2.5	2.9	5.0	1.7	2.2	-0.8
Age at last live birth	0.7	0.9	2.0	0.9	1.4	-0.2
Family relationship satisfaction	2.2	2.8	3.8	-1.1	-2.0	-1.8
Leg pain on walking	2.2	2.8	4.2	-1.8	-0.9	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.2	-1.5	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	-0.1	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.0	1.1	0.5
Medication: Aspirin	0.6	0.7	1.3	-1.2	-0.8	0.5
Supplements: Vitamin C	0.0	0.0	0.1	0.2	0.1	0.2
Knee pain experienced in last month	0.2	0.3	0.5	-0.4	-0.7	0.4
Hypertension (Self-reported)	2.3	6.3	8.6	-2.9	-2.7	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	5.5	-2.4	-1.9	0.4
Illnesses of father: Heart disease	0.3	0.4	0.6	0.6	0.3	-0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.4	0.3	-0.0
Smoking status: Previous	0.5	0.8	2.3	-1.5	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	7.0	1.0	-0.4	2.6
Whole body fat-free mass	0.8	4.4	11.2	3.3	1.4	0.1
Leg fat-free mass (right)	0.9	4.9	11.5	3.4	1.8	-0.4
Arm fat percentage (left)	0.2	1.0	1.9	1.4	0.7	-0.8
Average weekly red wine intake	0.2	0.3	0.6	0.8	-0.1	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.1	-1.1	0.9	-0.2
Mood swings	2.3	4.2	8.6	-2.0	-2.9	0.1
Loneliness, isolation	1.9	2.6	5.2	-2.3	-1.6	0.1
Long-standing illness, disability or infirmity	3.7	5.6	10.9	-3.3	-2.5	-0.1
Ever had bowel cancer screening	0.9	1.1	2.3	1.5	0.9	0.3
Diabetes diagnosed by doctor	0.6	1.0	1.5	-1.2	-1.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	5.2	-2.3	-1.9	1.4
Friendships satisfaction	0.3	0.4	0.9	-0.6	-0.9	-0.1
Qualifications: nursing, teaching	1.8	2.8	5.4	1.7	2.3	-0.4
Commuting to job workplace: Walk	0.5	0.5	0.8	-0.5	-0.7	0.9
Eye problems/disorders: Cataract	0.6	0.7	1.5	0.6	1.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	-1.3	-0.9	-0.5
Medication for cholesterol	1.0	1.6	3.0	1.0	1.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.2	-0.2	0.8
Back pain experienced in last month	1.6	2.3	5.7	-2.4	-1.0	0.1
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	-0.2	-0.6
Breast cancer (self-reported)	1.9	2.2	3.4	1.5	1.1	-1.9
Asthma (self-reported)	0.9	1.8	2.9	-1.2	-1.1	-1.7
Osteoporosis (self-reported)	0.9	1.1	1.9	1.4	0.8	-0.9
Osteoarthritis (self-reported)	1.5	1.9	2.3	-1.4	-1.2	-1.5
Medication: Aspirin	0.7	0.9	1.8	-1.3	-0.9	0.3
Medication: Gliclazide	0.6	0.7	1.6	-0.1	0.7	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.6	-0.9	-0.7	1.3
Smoking status: Current	0.7	1.1	1.6	-0.6	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.5	0.3	-0.3
Whole body water mass	0.8	4.6	11.5	3.4	1.5	0.1
Leg predicted mass (right)	1.0	5.1	11.9	3.5	1.8	-0.3
Arm fat mass (left)	0.4	1.5	3.6	1.9	0.6	-0.7
Number of self-reported non-cancer illnesses	0.9	1.5	2.3	-1.5	-1.4	0.5
Average weekly champagne plus white wine intake	1.6	2.2	3.2	1.8	1.8	0.4
Miserableness	3.0	5.3	8.3	-2.7	-2.9	0.6
Guilty feelings	1.7	2.5	4.1	-2.0	-1.7	0.6
Wears glasses or contact lenses	0.9	1.0	2.2	-0.7	0.5	-1.5
Ever taken oral contraceptive pill	4.2	4.7	10.2	0.7	1.9	3.2
Hearing aid user	1.2	1.3	1.9	-1.0	-1.4	1.1
Mother’s age at death	0.5	0.6	1.5	-0.5	0.3	-1.2
Financial situation satisfaction	1.7	2.1	4.0	-2.0	-1.5	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-0.8	-1.1	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.4	-0.7	-0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.2	-0.5	-0.4	-0.3
Medication: Blood pressure	1.4	2.6	6.1	-1.0	-2.5	0.9
Pain type(s) experienced in last month: Hip pain	1.5	1.9	2.8	-1.7	-1.5	0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.0	0.8	1.0	-1.0
High cholesterol (Self-reported)	2.2	3.9	8.3	-2.9	-1.8	0.0
Medication: Bendroflumethiazide	0.5	0.7	1.3	-0.7	-1.1	0.6
Medication: Paracetamol	1.4	2.2	4.1	-2.0	-1.4	-0.7
Medication: Lisinopril	0.1	0.1	0.2	-0.2	0.5	-0.3
Medication: Atorvastatin	0.7	0.9	2.7	0.1	0.0	1.6
Illnesses of father: High blood pressure	0.7	0.8	1.4	0.9	1.2	-0.4
Alcohol drinker status: Never	1.9	2.3	5.3	-2.3	-1.1	-0.7
Ever smoked	0.2	0.4	0.6	-0.8	0.4	-0.6
Basal metabolic rate	0.7	4.1	10.4	3.2	1.4	0.0
Leg fat percentage (left)	0.1	0.3	0.6	0.4	-0.1	-0.8
Arm fat-free mass (left)	0.5	2.4	6.7	2.6	0.6	-0.3
Number of operations (self-reported)	1.9	2.9	4.4	2.1	1.7	1.2
Average weekly beer plus cider intake	1.6	2.3	5.1	-1.3	-2.3	-0.5
Irritability	0.9	1.5	2.1	-1.1	-1.4	1.1
Risk taking	1.7	2.5	5.4	-1.0	-2.3	1.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.1	0.4	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.8	0.7	-0.1
Age started oral contraceptive pill	1.1	1.4	3.8	0.5	0.3	-2.0
Diastolic blood pressure, automated reading	0.8	2.4	2.6	-1.6	-1.4	1.6
Ever depressed for a whole week	1.4	1.8	4.2	-0.8	-0.7	-2.0
Unable to work because of sickness or disability	3.2	4.2	8.0	-2.1	-2.8	-0.0
Commuting to job workplace: Cycle	2.4	2.8	4.1	1.8	1.1	2.0
Myopia	2.1	3.1	5.2	2.3	2.0	-0.4
Vascular/heart problems diagnosed by doctor	1.9	5.2	8.2	2.9	2.3	-1.4
Cholesterol lowering medication	0.2	0.2	0.4	-0.2	-0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	-1.4	-1.2	-0.2
Pain experienced in last month	5.7	9.5	14.5	3.6	3.8	-1.0
Supplements: Calcium	0.3	0.3	0.6	-0.5	-0.5	-0.8
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.3	0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.3	0.2	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-1.1	-0.5	-0.4
Heart disease (siblings)	1.4	1.8	4.3	-2.1	-1.0	-0.2
Alcohol drinker status: Previous	1.4	1.6	2.9	-1.3	-1.7	0.1
Pack years of smoking	0.4	0.6	0.8	0.8	0.6	-0.9
Impedance of whole body	0.6	2.9	5.2	-1.7	-2.3	0.8
Leg fat mass (left)	0.2	0.8	2.1	1.4	0.3	-0.5
Arm predicted mass (left)	0.4	1.8	5.3	2.3	0.3	-0.1