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chr11:63,305,184-66,333,072

Best TWAS P=1.14e-16 · Best GWAS P=2.79e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Nerve Tibial	SIPA1	0.17	0.01	enet	19	0.06	6.8e-05	-6.5	8.3	1.1e-16	-0.42	0.13	0.62	TRUE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASEH2C	0.05	0.00	blup	32	0.02	1.1e-04	3.0	-8.2	2.2e-16	0.41	0.00	0.91	TRUE
7	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	4.0	-7.9	3.4e-15	0.45	0.43	0.30	TRUE
8	ROSMAP	Brain Pre-frontal Cortex	VEGFB	0.10	0.07	enet	6	0.05	1.5e-07	6.1	-6.4	1.4e-10	-0.02	0.00	1.00	TRUE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SIPA1	0.06	0.04	blup	43	0.05	4.6e-06	-4.3	6.1	1.2e-09	-0.52	0.03	0.93	TRUE
22	The Cancer Genome Atlas	Thyroid Carcinoma	SNX15	0.05	0.05	blup	52	0.05	1.6e-05	5.5	-5.6	1.8e-08	0.07	0.01	0.99	TRUE
1	CommonMind	Brain Pre-frontal Cortex	RNASEH2C	0.13	0.10	enet	14	0.10	4.3e-12	3.0	-5.5	5.0e-08	0.21	1.00	0.00	TRUE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAP3K11	0.06	0.02	blup	47	0.03	1.4e-04	-6.2	5.4	6.2e-08	-0.57	0.00	0.95	TRUE
21	The Cancer Genome Atlas	Thyroid Carcinoma	FIBP	0.04	0.00	blup	45	0.02	8.0e-03	2.5	5.2	2.4e-07	-0.33	0.00	0.04	TRUE
2	GTEx	Adipose Subcutaneous	RNASEH2C	0.15	0.07	lasso	5	0.09	1.3e-07	3.0	-5.1	2.8e-07	0.15	0.90	0.05	TRUE
9	YFS	Blood	FIBP	0.04	0.02	bslmm	343	0.03	6.4e-09	4.3	5.1	2.8e-07	-0.44	0.66	0.33	TRUE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	4.2	6.4	1.7e-10	-0.44	1.00	0.00	FALSE
14	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RNASEH2C	0.15	0.05	blup	32	0.05	3.1e-06	3.0	-6.2	4.6e-10	0.47	0.62	0.03	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SIPA1	0.04	0.00	blup	43	0.02	6.2e-03	-6.2	6.1	8.4e-10	-0.59	0.01	0.38	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	RNASEH2C	0.11	0.03	enet	5	0.06	3.6e-04	3.0	-5.8	7.1e-09	0.18	0.01	0.69	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	3.8	5.7	9.6e-09	-0.35	1.00	0.00	FALSE
10	YFS	Blood	SNX15	0.04	0.03	lasso	4	0.03	9.6e-10	5.6	-5.6	2.3e-08	0.04	0.00	1.00	FALSE
3	GTEx	Brain Cortex	CDCA5	0.21	0.03	lasso	4	0.04	2.5e-02	5.6	5.6	2.4e-08	-0.04	0.01	0.94	FALSE
4	GTEx	Cells Transformed fibroblasts	SIPA1	0.19	0.00	enet	30	0.05	2.5e-04	4.4	5.6	2.5e-08	-0.48	0.07	0.74	FALSE
6	METSIM	Adipose	VEGFB	0.12	0.06	enet	17	0.08	6.5e-12	5.2	-5.6	2.6e-08	-0.03	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX32	0.15	0.11	blup	60	0.15	6.0e-17	3.8	5.2	2.3e-07	-0.31	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SIPA1	0.09	0.03	blup	43	0.06	1.2e-07	-6.2	5.1	3.1e-07	-0.33	0.01	0.99	FALSE