Best TWAS P=1.14e-16 · Best GWAS P=2.79e-16 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RNASEH2C | 0.13 | 0.10 | enet | 14 | 0.10 | 4.3e-12 | 3.0 | -5.5 | 5.0e-08 | 0.21 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RNASEH2C | 0.15 | 0.07 | lasso | 5 | 0.09 | 1.3e-07 | 3.0 | -5.1 | 2.8e-07 | 0.15 | 0.90 | 0.05 | TRUE |
| 3 | GTEx | Brain Cortex | CDCA5 | 0.21 | 0.03 | lasso | 4 | 0.04 | 2.5e-02 | 5.6 | 5.6 | 2.4e-08 | -0.04 | 0.01 | 0.94 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SIPA1 | 0.19 | 0.00 | enet | 30 | 0.05 | 2.5e-04 | 4.4 | 5.6 | 2.5e-08 | -0.48 | 0.07 | 0.74 | FALSE |
| 5 | GTEx | Nerve Tibial | SIPA1 | 0.17 | 0.01 | enet | 19 | 0.06 | 6.8e-05 | -6.5 | 8.3 | 1.1e-16 | -0.42 | 0.13 | 0.62 | TRUE |
| 6 | METSIM | Adipose | VEGFB | 0.12 | 0.06 | enet | 17 | 0.08 | 6.5e-12 | 5.2 | -5.6 | 2.6e-08 | -0.03 | 0.00 | 1.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 4.0 | -7.9 | 3.4e-15 | 0.45 | 0.43 | 0.30 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | VEGFB | 0.10 | 0.07 | enet | 6 | 0.05 | 1.5e-07 | 6.1 | -6.4 | 1.4e-10 | -0.02 | 0.00 | 1.00 | TRUE |
| 9 | YFS | Blood | FIBP | 0.04 | 0.02 | bslmm | 343 | 0.03 | 6.4e-09 | 4.3 | 5.1 | 2.8e-07 | -0.44 | 0.66 | 0.33 | TRUE |
| 10 | YFS | Blood | SNX15 | 0.04 | 0.03 | lasso | 4 | 0.03 | 9.6e-10 | 5.6 | -5.6 | 2.3e-08 | 0.04 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASEH2C | 0.05 | 0.00 | blup | 32 | 0.02 | 1.1e-04 | 3.0 | -8.2 | 2.2e-16 | 0.41 | 0.00 | 0.91 | TRUE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | RNASEH2C | 0.11 | 0.03 | enet | 5 | 0.06 | 3.6e-04 | 3.0 | -5.8 | 7.1e-09 | 0.18 | 0.01 | 0.69 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | -4.3 | 6.1 | 1.2e-09 | -0.52 | 0.03 | 0.93 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RNASEH2C | 0.15 | 0.05 | blup | 32 | 0.05 | 3.1e-06 | 3.0 | -6.2 | 4.6e-10 | 0.47 | 0.62 | 0.03 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | -6.2 | 6.1 | 8.4e-10 | -0.59 | 0.01 | 0.38 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SNX32 | 0.15 | 0.11 | blup | 60 | 0.15 | 6.0e-17 | 3.8 | 5.2 | 2.3e-07 | -0.31 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNX32 | 0.14 | 0.09 | blup | 60 | 0.13 | 8.8e-15 | 3.8 | 5.7 | 9.6e-09 | -0.35 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SIPA1 | 0.09 | 0.03 | blup | 43 | 0.06 | 1.2e-07 | -6.2 | 5.1 | 3.1e-07 | -0.33 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAP3K11 | 0.06 | 0.02 | blup | 47 | 0.03 | 1.4e-04 | -6.2 | 5.4 | 6.2e-08 | -0.57 | 0.00 | 0.95 | TRUE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SNX32 | 0.12 | 0.13 | blup | 60 | 0.13 | 1.2e-09 | 4.2 | 6.4 | 1.7e-10 | -0.44 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | FIBP | 0.04 | 0.00 | blup | 45 | 0.02 | 8.0e-03 | 2.5 | 5.2 | 2.4e-07 | -0.33 | 0.00 | 0.04 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | SNX15 | 0.05 | 0.05 | blup | 52 | 0.05 | 1.6e-05 | 5.5 | -5.6 | 1.8e-08 | 0.07 | 0.01 | 0.99 | TRUE |