[Hub]/) : Traits : Cardiovascular Disease :

chr11:63,305,184-66,333,072

Best TWAS P=1.14e-16 · Best GWAS P=2.79e-16 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RNASEH2C 0.13 0.10 enet 14 0.10 4.3e-12 3.0 -5.5 5.0e-08 0.21 1.00 0.00 TRUE
2 GTEx Adipose Subcutaneous RNASEH2C 0.15 0.07 lasso 5 0.09 1.3e-07 3.0 -5.1 2.8e-07 0.15 0.90 0.05 TRUE
3 GTEx Brain Cortex CDCA5 0.21 0.03 lasso 4 0.04 2.5e-02 5.6 5.6 2.4e-08 -0.04 0.01 0.94 FALSE
4 GTEx Cells Transformed fibroblasts SIPA1 0.19 0.00 enet 30 0.05 2.5e-04 4.4 5.6 2.5e-08 -0.48 0.07 0.74 FALSE
5 GTEx Nerve Tibial SIPA1 0.17 0.01 enet 19 0.06 6.8e-05 -6.5 8.3 1.1e-16 -0.42 0.13 0.62 TRUE
6 METSIM Adipose VEGFB 0.12 0.06 enet 17 0.08 6.5e-12 5.2 -5.6 2.6e-08 -0.03 0.00 1.00 FALSE
7 ROSMAP Brain Pre-frontal Cortex CTSW 0.06 0.03 bslmm 328 0.03 3.6e-05 4.0 -7.9 3.4e-15 0.45 0.43 0.30 TRUE
8 ROSMAP Brain Pre-frontal Cortex VEGFB 0.10 0.07 enet 6 0.05 1.5e-07 6.1 -6.4 1.4e-10 -0.02 0.00 1.00 TRUE
9 YFS Blood FIBP 0.04 0.02 bslmm 343 0.03 6.4e-09 4.3 5.1 2.8e-07 -0.44 0.66 0.33 TRUE
10 YFS Blood SNX15 0.04 0.03 lasso 4 0.03 9.6e-10 5.6 -5.6 2.3e-08 0.04 0.00 1.00 FALSE
11 The Cancer Genome Atlas Breast Invasive Carcinoma RNASEH2C 0.05 0.00 blup 32 0.02 1.1e-04 3.0 -8.2 2.2e-16 0.41 0.00 0.91 TRUE
12 The Cancer Genome Atlas Colon Adenocarcinoma RNASEH2C 0.11 0.03 enet 5 0.06 3.6e-04 3.0 -5.8 7.1e-09 0.18 0.01 0.69 FALSE
13 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SIPA1 0.06 0.04 blup 43 0.05 4.6e-06 -4.3 6.1 1.2e-09 -0.52 0.03 0.93 TRUE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RNASEH2C 0.15 0.05 blup 32 0.05 3.1e-06 3.0 -6.2 4.6e-10 0.47 0.62 0.03 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SIPA1 0.04 0.00 blup 43 0.02 6.2e-03 -6.2 6.1 8.4e-10 -0.59 0.01 0.38 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX32 0.15 0.11 blup 60 0.15 6.0e-17 3.8 5.2 2.3e-07 -0.31 1.00 0.00 FALSE
17 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 3.8 5.7 9.6e-09 -0.35 1.00 0.00 FALSE
18 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SIPA1 0.09 0.03 blup 43 0.06 1.2e-07 -6.2 5.1 3.1e-07 -0.33 0.01 0.99 FALSE
19 The Cancer Genome Atlas Prostate Adenocarcinoma MAP3K11 0.06 0.02 blup 47 0.03 1.4e-04 -6.2 5.4 6.2e-08 -0.57 0.00 0.95 TRUE
20 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 4.2 6.4 1.7e-10 -0.44 1.00 0.00 FALSE
21 The Cancer Genome Atlas Thyroid Carcinoma FIBP 0.04 0.00 blup 45 0.02 8.0e-03 2.5 5.2 2.4e-07 -0.33 0.00 0.04 TRUE
22 The Cancer Genome Atlas Thyroid Carcinoma SNX15 0.05 0.05 blup 52 0.05 1.6e-05 5.5 -5.6 1.8e-08 0.07 0.01 0.99 TRUE