TWAS hub - SNX15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0401	0.0141	5.3e-07	0.033	0.017	0.021	0.026	0.028	4.7e-11	1.7e-06	1.3e-07	5.4e-09	9.6e-10
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0381	0.0187	2.3e-03	0.016	0.025	0.023	NA	0.005	5.7e-03	6.6e-04	1.1e-03	NA	7.4e-02
3	TCGA	Thyroid Carcinoma	0.0460	0.0220	7.7e-05	0.047	0.049	0.038	NA	0.043	2.3e-05	1.6e-05	1.3e-04	NA	4.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Cardiovascular Disease	8.3	27.4	31.7	-5.6	-4.4	-5.6
Hypertension (Self-reported)	6.0	16.6	22.0	-3.9	-3.6	-4.7
High blood pressure	5.7	15.9	21.6	-3.9	-3.3	-4.7
Frequency of tiredness / lethargy in last 2 weeks	5.7	9.2	11.6	-2.8	-2.9	-3.4
Gout (self-reported)	5.6	7.6	11.8	-1.9	-3.4	-2.7
Medication for cholesterol	5.6	8.5	10.6	3.0	2.5	3.2
Pulse wave peak to peak time	5.4	6.3	9.1	3.0	2.7	1.6
Vascular/heart problems diagnosed by doctor	5.4	14.8	19.0	3.7	3.5	4.4
Fractured/broken bones in last 5 years	5.2	6.7	9.5	3.1	2.6	2.0
Exposure to tobacco smoke outside home	4.9	6.5	9.1	-2.1	-2.5	-3.0
Diabetes (self-reported)	4.7	7.3	8.9	-3.0	-2.8	-2.2
Pulse wave Arterial Stiffness index	4.6	5.4	7.8	-2.8	-2.5	-1.5
HDL Cholesterol	4.5	7.4	9.1	3.0	2.2	2.9
Medication: Allopurinol	4.5	6.0	9.1	-1.8	-3.0	-2.4
Type 2 Diabetes (T2D) (2018)	4.2	7.9	10.1	-3.2	-2.3	-2.8
Diabetes (mother)	4.2	5.4	8.7	-2.6	-0.9	-3.0
Diabetes diagnosed by doctor	4.2	6.8	8.6	-2.9	-2.4	-2.4
Hair/balding pattern: Pattern 2	4.0	5.1	7.5	2.1	2.7	1.9
Had menopause	3.9	4.9	6.2	2.5	2.3	1.7
Medication for pain relief, constipation, heartburn	3.8	6.4	9.1	2.5	3.0	2.0
Medication: Simvastatin	3.7	5.5	7.8	-2.8	-2.6	-1.5
Medication: Blood pressure	3.7	6.5	8.8	-2.4	-3.0	-2.2
Medication: Blood pressure	3.7	7.1	11.6	-2.5	-1.8	-3.4
Alcohol drinker status: Previous	3.6	4.1	5.3	-2.3	-1.4	-2.3
Blood Red Count	3.5	34.1	41.6	-6.0	-4.9	-6.5
Multivitamins +/- minerals	3.5	4.5	6.8	-2.0	-2.6	-1.6
Body mass index (BMI)	3.5	14.8	15.4	-3.9	-3.9	-3.8
Mother’s age at death	3.3	4.2	5.4	2.1	2.3	1.7
Average weekly red wine intake	3.2	4.8	6.5	2.4	2.5	1.4
Age started oral contraceptive pill	3.1	3.9	6.3	1.9	2.5	1.3
Waist circumference	2.9	10.8	11.6	-3.4	-3.1	-3.3
Birth weight	2.9	6.2	9.6	2.5	1.6	3.1
Lupus	2.8	4.3	6.8	-2.6	-1.3	-2.1
Number of treatments/medications taken	2.8	5.0	8.0	-2.0	-2.8	-1.7
Arm fat mass (right)	2.8	11.7	12.5	-3.5	-3.3	-3.5
Diastolic blood pressure, automated reading	2.8	8.6	9.9	-2.8	-2.8	-3.1
BMI	2.7	15.5	17.6	-4.2	-4.2	-3.4
Medication: Atenolol	2.7	3.4	3.9	-2.0	-1.8	-1.7
Diabetes (father)	2.6	3.2	4.2	-1.9	-2.0	-1.4
Serious illness, injury or assault of a close relative in last 2 years	2.6	2.9	4.2	-2.1	-1.4	-1.6
Medication: Paracetamol	2.6	4.3	7.2	-1.8	-2.7	-1.6
Age at first live birth	2.6	4.6	10.9	1.6	3.3	0.3
Serious illness, injury or assault to yourself	2.5	3.1	4.4	2.1	1.9	1.0
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	4.1	-2.0	-1.6	-1.4
Illnesses of siblings	2.5	3.5	8.5	0.9	2.9	1.1
Type 2 Diabetes (T2D) (2012)	2.4	2.7	4.2	-2.1	-0.5	-1.9
Medication: Aspirin	2.4	3.1	4.2	-2.0	-1.5	-1.7
Smoking status: Current	2.4	3.7	4.0	2.0	2.0	1.8
Arm fat mass (left)	2.4	9.9	10.0	-3.2	-3.2	-3.1
Medication: Paracetamol	2.4	3.7	4.9	-1.8	-2.2	-1.7
Bipolar Disorder or Schizophrenia	2.3	5.5	14.9	1.2	3.9	0.4
Medication: Ramipril	2.3	2.9	5.0	-1.2	-1.5	-2.2
Arm fat percentage (right)	2.3	9.1	10.5	-3.2	-3.0	-2.8
Arm fat percentage (left)	2.3	9.3	11.0	-3.3	-2.9	-2.9
Number of self-reported non-cancer illnesses	2.3	3.9	4.8	-2.0	-2.2	-1.8
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.0	-1.8	-2.0	-1.3
Current tobacco smoking	2.2	3.6	4.5	1.9	2.1	1.7
Age when periods started (menarche)	2.2	5.3	6.4	2.2	2.2	2.5
Alcohol intake versus 10 years previously	2.2	3.3	4.9	-2.1	-0.8	-2.2
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	5.1	1.9	2.2	1.4
Medication: Aspirin	2.2	2.9	3.8	-2.0	-1.7	-1.4
Smoking status: Previous	2.2	3.3	5.3	-1.2	-1.8	-2.3
Cholesterol lowering medication	2.2	3.3	4.1	-2.0	-1.4	-1.9
Schizophrenia (2018)	2.1	4.4	12.8	0.7	3.6	0.1
Ever used hormone-replacement therapy (HRT)	2.1	2.7	3.6	1.9	1.7	1.2
Impedance of leg (right)	2.1	10.0	12.1	2.8	3.2	3.5
Illnesses of siblings: Diabetes	2.1	2.6	2.9	-1.5	-1.6	-1.7
Heart disease (siblings)	2.1	2.6	6.6	-1.0	-2.6	-0.4
Leg fat mass (left)	2.1	8.1	8.6	-2.9	-2.9	-2.6
Hip circumference	2.0	8.6	10.2	-2.6	-3.2	-2.9
Blood clot in the leg (DVT)	2.0	2.6	5.4	1.4	0.6	2.3
Alcohol intake frequency.	2.0	4.6	5.8	-2.4	-2.4	-1.5
Eye problems/disorders: Cataract	2.0	2.3	3.5	-1.1	-1.9	-1.5
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	5.3	1.3	0.8	2.3
Triglycerides	1.9	3.1	4.2	-2.0	-1.6	-1.7
Heel T-Score	1.9	14.8	18.5	-3.8	-4.3	-3.4
Systolic Blood Pressure	1.9	9.6	18.0	-2.7	-1.9	-4.2
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	5.7	-2.1	-1.7	-2.4
Hair/balding pattern: Pattern 3	1.9	2.8	6.0	-1.2	-2.5	-0.9
Neck or shoulder pain in last month	1.9	2.6	6.4	-1.2	-2.5	-0.2
Whole body fat mass	1.9	7.9	8.8	-2.8	-3.0	-2.6
Impedance of whole body	1.9	9.4	12.7	2.5	3.0	3.6
Fed-up feelings	1.8	3.2	5.4	-1.1	-1.7	-2.3
Leg fat mass (right)	1.8	7.0	7.6	-2.8	-2.7	-2.5
Leg fat percentage (left)	1.8	6.6	8.6	-2.9	-2.5	-2.2
Rheumatoid Arthritis	1.7	2.3	4.0	2.0	1.3	1.1
Supplements: Zinc	1.7	1.9	2.4	-1.6	-1.2	-1.4
Weight	1.7	8.2	9.4	-2.5	-3.0	-3.1
Impedance of arm (right)	1.7	8.0	10.3	2.3	2.9	3.2
Impedance of arm (left)	1.7	7.7	9.4	2.3	2.9	3.1
Length of working week for main job	1.7	1.9	2.3	-1.5	-1.1	-1.5
Body fat percentage	1.7	6.6	8.2	-2.9	-2.7	-2.0
High cholesterol (Self-reported)	1.7	3.0	3.2	-1.8	-1.7	-1.7
Chronotype (morning person)	1.6	3.7	5.8	2.3	0.2	2.4
Trunk fat mass	1.6	6.9	8.1	-2.6	-2.8	-2.4
Pulse wave reflection index	1.6	2.0	3.0	-1.7	-1.1	-1.3
Suffer from ‘nerves’	1.6	2.5	4.9	1.5	2.2	0.5
Medication: Gliclazide	1.6	1.9	3.6	-1.9	-0.8	-1.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.1	-1.1	-1.8	-1.2
Major Depression (MDD)	1.5	1.8	3.2	1.4	0.7	1.8
Hand grip strength (right)	1.5	4.1	5.8	-1.2	-2.3	-2.4
Mean time to correctly identify matches	1.5	2.9	3.9	1.2	2.0	1.8
Had major operations	1.5	1.8	2.8	-1.0	-1.2	-1.7
Fasting Glucose	1.4	1.6	3.1	-1.4	-0.1	-1.8
Sensitivity / hurt feelings	1.4	2.4	2.7	1.6	1.6	1.4
Trunk fat percentage	1.4	5.8	7.0	-2.6	-2.6	-1.9
Impedance of leg (left)	1.4	7.0	10.0	2.2	2.5	3.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.5	-0.7	-0.5	-2.1
Mineral and other dietary supplements	1.4	1.9	2.9	1.3	1.7	1.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.7	-0.9	-1.6	-1.1
Financial difficulties in last 2 years	1.3	1.7	4.5	-0.7	-0.3	-2.1
Prospective memory result	1.3	1.6	2.0	1.1	1.2	1.4
Exposure to tobacco smoke at home	1.3	1.5	2.0	-1.1	-1.4	-1.0
Medication: Amlodipine	1.3	1.8	4.5	-0.9	-0.3	-2.1
Leg fat percentage (right)	1.3	4.6	6.1	-2.5	-2.1	-1.8
Wears glasses or contact lenses	1.3	1.5	2.8	1.0	0.9	1.7
Ever taken oral contraceptive pill	1.3	1.4	3.6	-0.9	-0.1	-1.9
Medication: Lisinopril	1.3	1.7	2.3	-1.0	-1.3	-1.5
Unable to work because of sickness or disability	1.3	1.6	3.5	1.1	1.9	0.4
Worry (Nagel 2018)	1.2	2.5	3.2	1.8	1.8	1.1
Schizophrenia (2014)	1.2	2.6	7.8	0.2	2.8	-0.2
Systolic blood pressure, automated reading	1.2	3.5	6.0	-1.5	-1.5	-2.5
Vitamin and mineral supplements	1.2	1.6	1.7	1.3	1.3	1.3
Medication: Metformin	1.2	1.7	2.5	-1.6	-1.5	-0.6
Maternal smoking around birth	1.2	1.8	2.3	-1.5	-1.5	-0.9
Fluid intelligence score	1.2	2.4	2.9	-1.5	-1.5	-1.7
Lung cancer (father)	1.2	1.4	2.9	1.1	-0.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.4	1.6	1.0	1.0
Eye problems/disorders: None of the above	1.2	1.4	1.6	1.1	1.3	1.2
Age at last live birth	1.2	1.7	3.9	1.1	2.0	0.1
Breast Cancer	1.1	2.6	4.7	-1.4	-2.2	-1.1
Hearing difficulty/problems: Yes	1.1	1.7	4.2	0.8	2.1	0.3
Alcohol usually taken with meals	1.1	1.8	3.0	1.7	1.1	1.0
Time employed in main current job	1.1	1.3	1.8	1.3	1.3	0.7
Loud music exposure frequency	1.1	1.2	2.5	-0.8	-0.7	-1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.9	1.4	1.2	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.6	-1.0	-1.2	-1.6
Medication: Bendroflumethiazide	1.1	1.7	3.1	-1.3	-1.8	-0.5
Commuting to job workplace: Cycle	1.1	1.3	3.0	0.8	0.6	1.7
Nervous feelings	1.0	1.9	2.7	1.5	1.6	0.9
Medication: Cholesterol lowering	1.0	1.6	2.3	-1.5	-0.9	-1.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.9	0.2	-1.3	1.4
High blood pressure (siblings)	1.0	1.4	2.6	-0.6	-1.6	-1.1
Medication: Seretide 50 evohaler	1.0	1.1	2.1	1.0	0.4	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.1	-1.2	-1.5	-0.3
Leg pain on walking	1.0	1.2	1.9	-1.2	0.6	-1.4
Leg fat-free mass (right)	1.0	5.5	7.4	-1.8	-2.4	-2.7
Leg predicted mass (right)	1.0	5.5	7.3	-1.8	-2.5	-2.7
Commuting to job workplace: Public transport	1.0	1.1	2.4	-0.9	-0.4	-1.5
Pain experienced in last month	1.0	1.7	2.2	1.2	1.2	1.5
Bipolar Disorder (2018)	0.9	1.5	3.0	1.1	1.7	0.5
Intelligence (Savage-Jansen 2018)	0.9	2.7	2.7	-1.6	-1.7	-1.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.1	-0.9	-1.8	-1.5
Blood Eosinophil Count	0.9	6.7	7.2	-2.6	-2.5	-2.7
Relative age of first facial hair	0.9	2.0	4.6	-2.1	-0.7	-0.9
Pack years adult smoking proportion	0.9	1.4	1.9	-1.4	-1.0	-1.1
Leg fat-free mass (left)	0.9	4.7	6.6	-1.6	-2.2	-2.6
Taking other prescription medications	0.9	1.3	3.2	-0.8	-1.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	1.7	1.0	-1.3	1.1
Forced vital capacity (FVC), Best measure	0.9	3.3	6.8	2.6	1.7	0.6
Number of full sisters	0.9	1.1	2.6	0.1	1.6	-0.8
Knee pain experienced in last month	0.9	1.3	2.6	-1.1	-0.6	-1.6
Loneliness, isolation	0.9	1.2	3.1	-0.5	0.4	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.6	1.3	0.9	0.6
Average weekly champagne plus white wine intake	0.9	1.2	2.4	1.6	0.3	1.1
Schizophrenia vs Biploar Disorder	0.8	1.1	2.4	0.7	0.7	1.5
Crohns Disease (2012)	0.8	1.2	1.9	1.1	-0.8	1.4
Lung FVC	0.8	3.9	8.0	2.8	1.6	1.0
Supplements: Glucosamine	0.8	1.0	1.4	-1.1	-1.2	-0.7
High blood pressure (mother)	0.8	1.1	1.5	-1.2	-1.2	-0.6
Leg predicted mass (left)	0.8	4.3	6.2	-1.5	-2.1	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	2.4	-1.6	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.4	2.1	1.6	0.9
Birth weight of first child	0.8	1.5	2.3	-1.5	-1.3	-0.7
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.8	-1.0	-1.4	-0.3
Headache pain in last month	0.8	1.4	2.8	-1.2	-0.2	-1.7
Osteoarthritis (self-reported)	0.8	1.0	1.9	-0.9	-1.4	-0.7
Basal metabolic rate	0.8	4.4	6.7	-1.4	-2.1	-2.6
Myopia	0.8	1.2	2.5	-0.9	-0.5	-1.6
Pack years of smoking	0.8	1.1	1.4	-1.2	-1.0	-1.0
Hypothyroidism (self reported)	0.7	1.6	2.4	-1.0	-1.1	-1.6
Hair Pigment	0.7	19.5	28.6	5.2	1.6	5.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.3	-1.1	-0.4	-0.9
Mouth/teeth dental problems	0.7	1.0	2.4	0.5	0.6	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.1	-0.7	-1.1	-1.0
Number of full brothers	0.7	0.9	1.7	0.7	-1.3	0.8
Health satisfaction	0.7	0.8	1.5	0.6	0.8	1.2
Shortness of breath walking on level ground	0.7	0.8	1.4	0.2	1.2	0.9
Comparative height size at age 10	0.7	3.6	7.5	2.7	0.9	1.6
Supplements: Vitamin C	0.7	0.9	2.1	0.6	1.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.1	-1.0	-0.7	-1.1
Commuting to job workplace: Walk	0.7	0.7	0.9	-0.9	-0.7	-1.0
Back pain experienced in last month	0.7	1.1	2.7	-0.6	-0.3	-1.7
Medication: Atorvastatin	0.7	0.9	1.4	-0.6	1.0	-1.2
Basal cell carcinoma (self-reported)	0.7	0.8	1.4	-1.0	-0.2	-1.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	0.8	1.1	0.4
Lung FEV1/FVC ratio	0.6	3.1	6.4	-2.5	-0.9	-1.5
Past tobacco smoking	0.6	1.1	1.7	0.3	1.3	1.3
Pain all over the body in last month	0.6	0.7	1.5	-0.7	-0.2	-1.2
Father’s age at death	0.6	0.8	1.2	-1.1	-1.0	-0.6
Pulse rate	0.6	1.0	2.2	-1.5	-0.9	0.4
Arm fat-free mass (right)	0.6	3.0	5.1	-0.9	-1.8	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	0.5	-0.9	1.1
Arm predicted mass (right)	0.6	3.0	4.6	-0.9	-1.9	-2.1
Osteoporosis (self-reported)	0.6	0.7	1.6	-0.2	1.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.5	0.9	1.6	0.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	0.8	1.1	0.1
Arm fat-free mass (left)	0.6	3.3	5.3	-1.0	-1.9	-2.3
Ever depressed for a whole week	0.6	0.7	1.5	-0.8	-0.2	-1.2
Reaction Time	0.5	1.0	1.7	0.4	1.3	1.1
Age at First Birth	0.5	0.7	1.4	1.2	0.6	0.5
Medication for hormone replacement therapy	0.5	0.6	0.8	0.7	0.9	0.7
Average weekly fortified wine intake	0.5	0.5	1.4	0.4	1.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.2	-0.6	-0.7	-1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	1.0	0.3	0.6
Hearing difficulty/problems with background noise	0.5	0.9	1.5	-0.1	1.0	-1.2
Medication: Lansoprazole	0.5	0.6	1.0	-1.0	-0.8	-0.1
Peak expiratory flow (PEF)	0.5	1.1	2.4	1.5	0.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.4	-0.5	-1.2	-1.1
Comparative body size at age 10	0.5	1.4	1.6	-1.3	-1.1	-1.2
Qualifications: College or University degree	0.5	1.6	4.0	0.9	2.0	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	1.1	0.8	-0.1
Angina (self-reported)	0.5	0.7	0.9	-0.9	-0.9	-0.6
Overall health rating	0.5	1.1	1.6	-1.1	-0.7	-1.3
Ever had bowel cancer screening	0.5	0.6	1.2	0.6	-0.4	1.1
Whole body water mass	0.5	2.7	4.7	-0.7	-1.7	-2.2
Guilty feelings	0.5	0.7	0.9	0.9	0.9	-0.7
Hearing aid user	0.5	0.6	0.8	0.5	0.8	0.9
Average weekly beer plus cider intake	0.5	0.7	1.4	-1.2	-0.4	-0.7
Arm predicted mass (left)	0.5	2.4	3.5	-0.7	-1.7	-1.9
Mean Putamen Volume	0.4	0.5	0.7	-0.9	-0.2	-0.8
HbA1C	0.4	0.5	0.6	-0.5	-0.8	-0.7
Blood White Count	0.4	2.8	5.0	-1.5	-2.2	-1.1
Height	0.4	7.3	14.1	3.8	1.4	2.4
Hand grip strength (left)	0.4	1.2	2.9	-0.0	-0.8	-1.7
Neuroticism score	0.4	0.8	1.9	0.3	0.8	-1.4
Asthma	0.4	0.8	1.8	-0.7	-1.3	-0.3
Emphysema/chronic bronchitis	0.4	0.5	1.1	0.5	0.1	1.0
Medication: Ibuprofen	0.4	0.5	0.6	-0.8	-0.7	-0.7
Illnesses of father: Heart disease	0.4	0.5	1.1	0.5	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.0	-0.7	-0.4	-1.4
Whole body fat-free mass	0.4	2.5	4.5	-0.7	-1.6	-2.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	-0.4	0.9	-0.8
Mood swings	0.4	0.8	2.1	-0.3	0.4	-1.5
Illnesses of father: High blood pressure	0.4	0.4	0.8	-0.7	-0.1	-0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	-0.4	-0.2	-1.3
Crohns Disease (2017)	0.3	0.7	1.1	0.6	-1.0	0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	0.3	-1.1	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	-0.6	-0.6	-0.7
Neuroticism (2016)	0.3	0.5	1.0	0.5	1.0	-0.5
Primary Biliary Cirrhosis	0.3	0.5	0.9	-0.2	-1.0	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	0.5	0.8	-0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.3	0.9	0.3
Angina	0.3	0.4	0.8	-0.7	-0.9	-0.3
Relative age voice broke	0.3	0.5	1.1	-1.0	0.6	0.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-1.0	-0.3	-0.1
Forced vital capacity (FVC)	0.3	1.2	3.2	1.8	0.3	0.3
Trunk fat-free mass	0.3	1.8	3.9	-0.2	-1.2	-2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	-0.6	0.5	-1.1
Depression (self-reported)	0.3	0.3	0.7	0.5	-0.9	-0.1
Trunk predicted mass	0.3	1.7	3.7	-0.1	-1.2	-1.9
Standing height	0.3	3.0	6.2	2.5	1.4	0.8
Breastfed as a baby	0.3	0.4	0.9	0.4	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	0.4	0.1	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.2	-1.0	0.5
Worry too long after embarrassment	0.3	0.6	0.8	-0.5	0.8	-0.9
Pulse rate, automated reading	0.3	1.0	2.1	-1.5	-0.9	0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.6	-0.1	-0.8	0.8
Friendships satisfaction	0.3	0.4	1.1	-0.3	-1.0	0.1
Miserableness	0.3	0.5	1.0	-0.5	-0.5	-1.0
Number of operations (self-reported)	0.3	0.4	1.3	-0.1	-1.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.7	0.1	0.8
Supplements: Calcium	0.3	0.3	0.6	0.4	0.1	0.8
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.7	0.9	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.8	0.4	0.2
Prostate Cancer	0.2	0.3	0.6	-0.2	-0.3	-0.8
Ulcerative Colitis	0.2	0.3	0.5	-0.7	-0.1	-0.5
Waist Hip Ratio (WHR)	0.2	0.8	1.2	-1.1	0.7	-0.8
Neuroticism	0.2	0.5	0.6	0.7	0.7	-0.8
Average weekly spirits intake	0.2	0.2	0.4	-0.5	-0.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.2	-0.1	-0.8
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.3	-0.7	0.3
Qualifications: None of the above	0.2	0.4	1.2	0.3	-0.1	1.1
Heart attack	0.2	0.3	0.4	-0.6	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	1.2	0.4	0.2
Glaucoma (self-reported)	0.2	0.3	0.5	0.4	0.7	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	-0.4	-1.0	0.1
Number of children fathered	0.2	0.2	0.3	0.6	-0.2	0.4
Heart disease (mother)	0.2	0.2	0.3	0.4	0.5	-0.5
Family relationship satisfaction	0.2	0.2	0.4	-0.2	-0.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.2	0.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	0.2	-0.9	-0.1
Breast cancer (self-reported)	0.2	0.2	0.6	0.2	0.1	0.7
Asthma (self-reported)	0.2	0.5	1.2	-0.4	-1.1	-0.2
Financial situation satisfaction	0.2	0.3	0.3	-0.5	-0.6	-0.6
Alcohol drinker status: Never	0.2	0.2	0.4	-0.6	-0.5	0.2
Ever smoked	0.2	0.4	0.7	0.6	-0.0	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	-0.6	-0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.4	-0.6	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	-0.3	-0.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.0	-0.5	0.3
Ovarian Cancer	0.1	0.1	0.2	0.1	0.5	0.4
LDL Cholesterol	0.1	0.1	0.3	0.0	0.5	-0.0
Blood Platelet Count	0.1	1.1	2.3	0.8	1.5	0.6
Smoking Status	0.1	0.1	0.2	0.2	-0.5	-0.3
Respiratory disease	0.1	0.3	0.6	0.1	-0.8	0.6
Tanning	0.1	0.8	1.6	1.3	0.6	0.7
Medication: Co-codamol	0.1	0.2	0.4	0.1	0.6	0.3
Severe depression (siblings)	0.1	0.1	0.3	-0.3	0.1	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.1	0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.3	0.6	-0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	-0.1	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	0.4	-0.3
Sitting height	0.1	0.4	1.0	0.4	-0.4	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.6	-0.1	-0.4
Had other major operations	0.1	0.1	0.4	0.6	-0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	-0.6	-0.2	0.1
Worrier / anxious feelings	0.1	0.3	0.4	0.3	0.5	-0.7
Falls in the last year	0.1	0.1	0.2	-0.0	0.5	-0.1
Number of live births	0.1	0.1	0.2	0.5	0.4	0.2
Happiness	0.1	0.2	0.3	0.5	0.4	0.2
Noisy workplace	0.1	0.1	0.2	-0.3	-0.2	-0.5
Illnesses of mother	0.1	0.2	0.4	-0.2	-0.6	-0.3
Medication: Omeprazole	0.1	0.1	0.2	0.5	0.2	0.4
Chest pain or discomfort	0.1	0.1	0.2	0.0	-0.5	-0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.3	-0.2	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.3	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	-0.2	-0.3	-0.6
Irritability	0.1	0.2	0.4	0.6	-0.2	-0.3
Risk taking	0.1	0.1	0.2	-0.1	0.5	-0.3
Depression (Nagel 2018)	0.0	0.1	0.1	0.0	-0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.4	0.0	0.0
Allergy or Eczema	0.0	0.1	0.2	0.2	-0.2	-0.4
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.1	-0.0	-0.4
Number of incorrect matches in round	0.0	0.0	0.0	-0.2	0.2	-0.2
Allergy	0.0	0.1	0.2	-0.0	0.5	-0.3
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.2	-0.0	0.4
Tense / ‘highly strung’	0.0	0.1	0.2	-0.2	-0.1	-0.4
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.4	0.4	-0.0
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.3	-0.2	-0.2

Hub : Genes

SNX15

Models

Trait associations