TWAS hub - CDCA5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2140	0.0780	2.2e-03	0.033	NA	0.002	NA	0.043	4.4e-02	NA	0.28000	NA	0.02500
2	ROSMAP	Brain Pre-frontal Cortex	0.0815	0.0293	1.6e-05	0.039	0.041	0.022	0.042	0.028	7.9e-06	4.8e-06	0.00067	3.4e-06	0.00012

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
HDL Cholesterol	6.6	10.9	13.0	-3.0	-3.6
Cardiovascular Disease	6.5	21.4	31.1	5.6	3.4
Diabetes diagnosed by doctor	5.3	8.8	9.3	2.9	3.1
Diabetes (self-reported)	5.1	7.9	8.5	2.9	2.7
Fractured/broken bones in last 5 years	4.9	6.3	10.4	-3.2	-1.5
Hypertension (Self-reported)	4.7	13.0	14.8	3.9	3.3
High blood pressure	4.5	12.6	14.7	3.8	3.2
Pulse wave peak to peak time	4.5	5.3	9.5	-3.1	-1.1
Type 2 Diabetes (T2D) (2018)	4.4	8.3	9.7	3.1	2.6
Diabetes (mother)	4.3	5.5	6.8	2.6	2.1
Body mass index (BMI)	4.3	18.3	20.3	4.0	4.5
Vascular/heart problems diagnosed by doctor	4.2	11.5	13.7	-3.7	-3.0
Exposure to tobacco smoke outside home	3.9	5.2	5.5	2.2	2.4
Medication for cholesterol	3.9	6.0	8.7	-3.0	-1.8
Alcohol drinker status: Previous	3.9	4.4	5.7	2.4	1.8
Pulse wave Arterial Stiffness index	3.8	4.5	8.3	2.9	0.8
Type 2 Diabetes (T2D) (2012)	3.6	4.2	4.5	2.0	2.1
BMI	3.3	19.3	19.5	4.4	4.4
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	9.4	3.1	1.2
Mother’s age at death	3.2	4.1	4.1	-2.0	-2.0
Arm fat mass (right)	3.1	12.7	12.9	3.6	3.5
Medication: Ramipril	3.0	3.9	6.2	1.2	2.5
Impedance of arm (left)	3.0	13.8	22.0	-2.3	-4.7
Blood Red Count	2.9	27.8	38.3	6.2	4.2
Diabetes (father)	2.9	3.5	4.2	1.7	2.0
Waist circumference	2.9	10.7	12.3	3.5	3.0
Hair/balding pattern: Pattern 2	2.8	3.6	3.8	-1.9	-1.9
Had menopause	2.8	3.5	6.5	-2.5	-0.7
Impedance of arm (right)	2.8	12.9	19.8	-2.4	-4.5
Medication: Simvastatin	2.7	3.9	7.2	2.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	4.5	-1.2	-2.1
Impedance of whole body	2.7	13.5	20.2	-2.6	-4.5
Triglycerides	2.6	4.2	4.5	2.1	2.0
Arm fat percentage (right)	2.6	10.2	11.0	3.3	3.1
Medication: Blood pressure	2.6	5.0	6.6	2.6	1.9
Leg fat percentage (left)	2.6	9.4	9.6	3.0	3.1
Lupus	2.5	3.8	6.2	2.5	1.2
Impedance of leg (right)	2.5	12.1	15.8	-2.9	-4.0
Birth weight	2.5	5.5	6.2	-2.5	-2.2
Arm fat percentage (left)	2.5	10.0	11.6	3.4	2.9
Arm fat mass (left)	2.5	10.5	10.8	3.3	3.2
Rheumatoid Arthritis	2.4	3.3	3.7	-1.9	-1.7
Ever used hormone-replacement therapy (HRT)	2.4	3.0	3.4	-1.8	-1.6
Medication: Blood pressure	2.4	4.3	5.9	2.4	1.7
Medication: Allopurinol	2.4	3.2	3.5	1.9	-1.7
Leg fat mass (left)	2.4	9.4	9.5	3.1	3.1
Supplements: Zinc	2.3	2.5	2.8	1.5	1.7
Leg fat mass (right)	2.3	8.9	9.5	2.9	3.1
Average weekly red wine intake	2.3	3.3	6.6	-2.6	-0.3
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.4	2.1	1.0
Worry (Nagel 2018)	2.1	4.4	6.0	-1.7	-2.4
Leg fat percentage (right)	2.1	7.5	8.5	2.6	2.9
Medication: Atenolol	2.0	2.5	3.5	1.9	1.2
Impedance of leg (left)	2.0	9.7	14.3	-2.3	-3.8
Medication for pain relief, constipation, heartburn	2.0	3.4	6.7	-2.6	-0.4
Current tobacco smoking	1.9	3.1	3.7	-1.9	-1.6
Serious illness, injury or assault to yourself	1.9	2.3	4.1	-2.0	-0.7
Length of working week for main job	1.9	2.1	2.6	1.6	1.3
Gout (self-reported)	1.9	2.6	3.8	1.9	-1.2
Forced vital capacity (FVC), Best measure	1.9	6.8	7.7	-2.5	-2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	2.7	-1.5	-1.6
Whole body fat mass	1.9	7.8	8.8	3.0	2.6
Medication: Aspirin	1.9	2.5	4.2	2.0	0.9
Smoking status: Current	1.9	3.0	4.3	-2.1	-1.4
Number of treatments/medications taken	1.8	3.2	4.3	2.1	1.5
Nervous feelings	1.8	3.4	4.8	-1.4	-2.2
Number of self-reported non-cancer illnesses	1.8	3.2	4.2	2.0	1.5
Age started oral contraceptive pill	1.8	2.3	4.2	-2.0	0.6
Cholesterol lowering medication	1.8	2.6	4.5	2.1	0.9
Fasting Glucose	1.7	2.1	2.5	1.6	1.3
Sensitivity / hurt feelings	1.7	2.9	3.8	-1.4	-1.9
Age when periods started (menarche)	1.7	4.1	4.5	-2.1	-1.9
Multivitamins +/- minerals	1.7	2.2	4.1	2.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.8	1.9	0.3
Body fat percentage	1.7	6.6	8.9	3.0	2.1
Age at first live birth	1.7	3.0	3.5	-1.6	-1.9
Medication: Aspirin	1.7	2.2	4.0	2.0	0.7
Average weekly champagne plus white wine intake	1.7	2.3	2.6	-1.6	-1.4
Diastolic blood pressure, automated reading	1.7	5.2	8.7	3.0	1.3
Lung FVC	1.6	8.1	9.4	-2.6	-3.1
Weight	1.6	7.7	8.0	2.7	2.8
Hip circumference	1.6	6.7	8.3	2.9	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	6.6	-2.0	-2.6
Pulse wave reflection index	1.6	2.0	3.5	1.9	0.7
Illnesses of siblings: Diabetes	1.6	2.0	2.5	1.6	1.2
Systolic Blood Pressure	1.5	7.4	8.1	2.6	2.8
Medication: Metformin	1.5	2.1	2.5	1.6	1.3
Alcohol intake versus 10 years previously	1.5	2.3	4.4	2.1	0.5
Alcohol intake frequency.	1.5	3.5	7.0	2.6	0.2
Suffer from ‘nerves’	1.5	2.3	2.3	-1.5	-1.5
Medication: Gliclazide	1.5	1.7	3.2	1.8	0.5
Prostate Cancer	1.4	2.0	3.9	0.4	2.0
Chronotype (morning person)	1.4	3.3	6.0	-2.4	-0.7
Systolic blood pressure, automated reading	1.4	4.0	5.7	1.5	2.4
Trunk fat mass	1.4	5.8	8.0	2.8	1.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	3.5	-1.9	-1.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.5	1.9	0.4
Medication: Paracetamol	1.4	2.1	4.2	2.0	0.3
Major Depression (MDD)	1.3	1.6	1.6	-1.3	-1.2
Breast Cancer	1.3	3.2	4.8	1.3	2.2
Heel T-Score	1.3	10.6	16.3	4.0	2.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	1.8	-1.0	-1.4
Exposure to tobacco smoke at home	1.3	1.5	1.6	1.2	1.2
Number of children fathered	1.3	1.5	2.8	-0.3	-1.7
Comparative height size at age 10	1.3	7.0	7.1	-2.6	-2.7
Medication: Bendroflumethiazide	1.3	2.0	2.3	1.3	1.5
Relative age of first facial hair	1.2	2.4	4.3	2.1	0.7
Pack years adult smoking proportion	1.2	1.8	2.1	1.4	1.3
Trunk fat percentage	1.2	4.9	7.7	2.8	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	5.4	2.3	0.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.3	0.8	1.5
Financial difficulties in last 2 years	1.2	1.6	2.7	0.8	1.6
Medication: Paracetamol	1.2	1.9	3.8	2.0	-0.1
Tinnitus: Yes, now most or all of the time	1.2	1.5	1.8	1.0	1.4
Alcohol usually taken with meals	1.1	1.7	3.0	-1.7	-0.7
Forced vital capacity (FVC)	1.1	4.2	5.6	-1.7	-2.4
Illnesses of siblings	1.1	1.5	2.1	-1.0	-1.4
Time employed in main current job	1.1	1.3	1.8	-1.3	-0.9
Supplements: Vitamin C	1.1	1.3	2.3	-0.6	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.3	1.1	1.1
Unable to work because of sickness or disability	1.1	1.5	1.6	-1.1	-1.3
Pack years of smoking	1.1	1.6	1.6	1.2	1.3
Hair/balding pattern: Pattern 3	1.0	1.5	1.7	1.1	1.3
Lung cancer (father)	1.0	1.2	1.3	-1.1	-1.1
Birth weight of first child	1.0	1.8	2.4	1.6	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.3	1.3	1.1	-1.1
Knee pain experienced in last month	1.0	1.6	1.9	1.1	1.4
Eye problems/disorders: Cataract	1.0	1.2	1.6	1.3	0.9
Lung FEV1/FVC ratio	0.9	4.3	5.3	2.3	1.9
Medication: Co-codamol	0.9	1.0	2.0	0.0	-1.4
Maternal smoking around birth	0.9	1.4	2.6	1.6	-0.4
Peak expiratory flow (PEF)	0.9	2.1	2.2	-1.5	-1.4
Blood clot in the leg (DVT)	0.9	1.2	1.6	-1.3	-0.8
Comparative body size at age 10	0.9	2.6	3.4	1.4	1.8
Family relationship satisfaction	0.9	1.1	2.2	0.0	1.5
Guilty feelings	0.9	1.4	2.2	-0.8	-1.5
High cholesterol (Self-reported)	0.9	1.7	3.2	1.8	0.3
Myopia	0.9	1.4	1.8	1.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.4	-1.2	-1.0
Age at First Birth	0.8	1.1	1.6	-1.3	-0.8
Height	0.8	16.0	20.1	-3.5	-4.5
Medication for hormone replacement therapy	0.8	0.9	1.3	-0.7	-1.1
Fluid intelligence score	0.8	1.6	2.5	1.6	0.8
Medication: Cholesterol lowering	0.8	1.2	2.0	1.4	0.6
Prospective memory result	0.8	1.0	1.3	-1.1	-0.8
Standing height	0.8	7.6	9.7	-2.4	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.6	-0.9	-1.3
Neck or shoulder pain in last month	0.8	1.1	1.8	1.3	-0.7
Leg pain on walking	0.8	1.0	1.1	1.1	0.9
Mineral and other dietary supplements	0.8	1.0	2.0	-1.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.6	-0.6	-1.3
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.2	1.8	1.0
Schizophrenia vs Biploar Disorder	0.7	1.0	1.6	-0.6	-1.3
Hair Pigment	0.7	19.1	25.1	-5.0	-3.6
Hearing difficulty/problems: Yes	0.7	1.1	1.6	-0.8	-1.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.2	1.1	-0.6
Severe depression (siblings)	0.7	0.8	1.6	0.2	1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.2	-1.1	-1.8
Eye problems/disorders: None of the above	0.7	0.8	1.6	-1.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	1.2	0.6
Age at last live birth	0.7	1.0	1.0	-1.0	-1.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-1.3	-0.1
Smoking status: Previous	0.7	1.0	1.6	1.2	0.7
Leg fat-free mass (right)	0.7	3.6	3.7	1.9	1.9
Leg predicted mass (right)	0.7	3.6	3.8	1.9	1.9
Wears glasses or contact lenses	0.7	0.9	0.9	-1.0	-0.9
Hearing aid user	0.7	0.8	1.4	-0.5	-1.2
Financial situation satisfaction	0.7	0.9	1.5	0.4	1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.6	0.3	-1.3
Alcohol drinker status: Never	0.7	0.9	1.0	0.9	-1.0
Ever smoked	0.7	1.2	2.0	-0.6	-1.4
Heart disease (siblings)	0.7	0.8	1.2	1.1	0.6
Blood Eosinophil Count	0.6	4.3	6.3	2.5	1.5
Smoking Status	0.6	1.4	2.9	-0.1	-1.7
Vitamin and mineral supplements	0.6	0.8	1.5	-1.2	-0.3
Leg fat-free mass (left)	0.6	3.3	3.5	1.7	1.9
Stomach or abdominal pain in last month	0.6	0.7	1.4	-0.3	-1.2
Supplements: Glucosamine	0.6	0.7	1.1	1.0	0.6
Leg predicted mass (left)	0.6	3.1	3.3	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.9	1.7	-0.0
Father’s age at death	0.6	0.8	1.4	1.2	-0.4
Tense / ‘highly strung’	0.6	1.0	1.9	0.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	-1.1	0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-1.1	-0.5
Had major operations	0.6	0.7	1.3	1.1	0.4
Illnesses of father: Heart disease	0.6	0.8	1.4	-0.5	1.2
Loneliness, isolation	0.6	0.8	1.2	0.6	1.1
Ever depressed for a whole week	0.6	0.7	0.8	0.9	0.8
Bipolar Disorder (2018)	0.5	0.8	1.5	-1.2	-0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.1	0.5	1.0
Hand grip strength (right)	0.5	1.4	1.6	1.3	1.1
Fed-up feelings	0.5	1.0	1.8	1.4	0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.4	-1.1
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	0.3	-1.4
High blood pressure (mother)	0.5	0.8	1.5	1.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.2	-0.5	-1.1
Pulse rate	0.5	0.9	1.7	1.3	0.3
Medication: Lansoprazole	0.5	0.6	1.2	1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.7	0.8	0.9
Headache pain in last month	0.5	0.9	1.7	1.3	-0.2
High blood pressure (siblings)	0.5	0.7	1.0	0.7	1.0
Mean time to correctly identify matches	0.5	1.0	1.6	-1.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-0.3	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.3	0.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.0	0.8	1.0
Osteoporosis (self-reported)	0.5	0.6	1.2	0.0	1.1
Medication: Lisinopril	0.5	0.7	0.8	0.9	0.7
Basal metabolic rate	0.5	2.9	3.5	1.6	1.9
Arm fat-free mass (left)	0.5	2.6	3.8	1.2	1.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.7	0.7	-0.9
Pain experienced in last month	0.5	0.9	1.7	-1.3	0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	1.1	0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	1.6	-1.3	-0.6
Neuroticism (Nagel 2018)	0.4	1.0	2.0	-0.3	-1.4
Ovarian Cancer	0.4	0.5	1.1	-0.0	-1.0
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	0.5	0.9
Primary Biliary Cirrhosis	0.4	0.6	1.0	0.3	1.0
Blood Platelet Count	0.4	4.2	8.0	-0.6	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.6	0.8	0.7
Relative age voice broke	0.4	0.7	0.9	1.0	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	1.0	0.2
Pain all over the body in last month	0.4	0.4	0.6	0.8	0.6
Worrier / anxious feelings	0.4	0.8	1.7	-0.1	-1.3
Illnesses of mother	0.4	0.4	0.9	0.2	0.9
Medication: Amlodipine	0.4	0.5	1.0	1.0	0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.1	-1.0
Arm fat-free mass (right)	0.4	2.2	3.2	1.1	1.8
Shortness of breath walking on level ground	0.4	0.5	1.0	-0.1	-1.0
Arm predicted mass (right)	0.4	2.0	2.8	1.1	1.7
Pulse rate, automated reading	0.4	1.4	1.7	1.3	1.0
Long-standing illness, disability or infirmity	0.4	0.6	1.1	0.3	1.0
Breast cancer (self-reported)	0.4	0.5	1.0	-0.2	-1.0
Ever taken oral contraceptive pill	0.4	0.5	0.7	0.8	0.5
Commuting to job workplace: Public transport	0.4	0.5	0.7	0.8	0.6
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	-0.9	-0.4
Average weekly beer plus cider intake	0.4	0.5	1.0	1.0	-0.2
Irritability	0.4	0.6	1.1	-0.5	-1.0
Arm predicted mass (left)	0.4	1.9	3.0	0.9	1.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	-0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	1.1	0.3
Crohns Disease (2012)	0.3	0.5	0.9	-1.0	-0.0
Mean Putamen Volume	0.3	0.4	0.6	0.8	0.3
Ulcerative Colitis	0.3	0.5	0.6	0.7	0.6
Hypothyroidism (self reported)	0.3	0.8	1.3	1.1	0.5
Taking other prescription medications	0.3	0.5	0.9	1.0	-0.3
Allergy	0.3	0.7	1.3	-0.2	1.1
Asthma	0.3	0.6	0.7	0.9	0.6
Breastfed as a baby	0.3	0.4	0.6	-0.4	-0.7
Loud music exposure frequency	0.3	0.4	0.6	0.8	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	0.4	1.0
Angina (self-reported)	0.3	0.4	0.8	0.9	0.2
Medication: Ibuprofen	0.3	0.3	0.7	0.8	-0.2
Medication: Omeprazole	0.3	0.4	0.7	-0.4	-0.8
Overall health rating	0.3	0.7	1.5	1.2	-0.0
Whole body fat-free mass	0.3	1.5	2.2	0.8	1.5
Commuting to job workplace: Walk	0.3	0.4	0.7	0.8	0.1
Osteoarthritis (self-reported)	0.3	0.3	0.6	0.8	0.2
Risk taking	0.3	0.4	0.8	0.1	0.9
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.8	-0.3
Schizophrenia (2018)	0.2	0.4	0.4	-0.7	-0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.7	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.4	-0.5
HbA1C	0.2	0.2	0.3	0.5	-0.3
Schizophrenia (2014)	0.2	0.5	1.0	-0.2	-1.0
Blood White Count	0.2	1.1	2.0	1.4	0.5
Neuroticism	0.2	0.6	1.0	-0.5	-1.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.3	-0.7
Angina	0.2	0.2	0.4	0.6	0.0
Qualifications: None of the above	0.2	0.4	0.7	-0.2	-0.9
Heart attack	0.2	0.3	0.5	0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.8	-0.0
Trunk fat-free mass	0.2	0.9	1.7	0.4	1.3
Number of live births	0.2	0.3	0.5	-0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	-0.3
Trunk predicted mass	0.2	0.9	1.7	0.3	1.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.3	-0.4	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	0.2	-0.7
Number of full brothers	0.2	0.3	0.5	-0.7	0.3
Worry too long after embarrassment	0.2	0.3	0.4	0.7	-0.3
Health satisfaction	0.2	0.3	0.5	-0.7	0.3
Qualifications: College or University degree	0.2	0.6	1.1	-1.0	0.5
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.6	0.8	0.1
Friendships satisfaction	0.2	0.2	0.3	0.3	0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	-0.3
Asthma (self-reported)	0.2	0.3	0.4	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.9	-0.2
Whole body water mass	0.2	1.4	2.0	0.9	1.4
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.7	-0.1
Number of operations (self-reported)	0.2	0.3	0.5	0.4	-0.7
Supplements: Calcium	0.2	0.2	0.2	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	0.3
Depression (Nagel 2018)	0.1	0.1	0.3	0.1	-0.5
Crohns Disease (2017)	0.1	0.2	0.3	-0.4	-0.5
Reaction Time	0.1	0.3	0.3	-0.5	-0.5
Neuroticism (2016)	0.1	0.2	0.2	-0.5	-0.3
Waist Hip Ratio (WHR)	0.1	0.5	0.8	0.9	0.4
Allergy or Eczema	0.1	0.3	0.6	0.0	-0.7
Tanning	0.1	1.0	1.9	-1.4	-0.2
Hand grip strength (left)	0.1	0.2	0.5	0.0	0.7
Average weekly spirits intake	0.1	0.1	0.2	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.4	-0.4
Average weekly fortified wine intake	0.1	0.2	0.2	-0.3	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	0.0
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.1	-0.5
Past tobacco smoking	0.1	0.1	0.2	-0.4	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.2	-0.6
Had other major operations	0.1	0.1	0.3	-0.5	-0.2
Mouth/teeth dental problems	0.1	0.2	0.2	-0.5	-0.4
Neuroticism score	0.1	0.2	0.4	-0.1	-0.7
Happiness	0.1	0.2	0.3	-0.5	0.2
Depression (self-reported)	0.1	0.1	0.1	-0.4	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	-0.5	0.4
Glaucoma (self-reported)	0.1	0.1	0.2	-0.5	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.6	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	-0.1
Heart disease (mother)	0.1	0.1	0.2	-0.4	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.5	0.2
Ever had bowel cancer screening	0.1	0.1	0.3	-0.5	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.2	0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.2	0.3
Miserableness	0.1	0.2	0.4	0.6	0.2
Medication: Atorvastatin	0.1	0.2	0.4	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.5	0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.2	-0.2
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	-0.0	-0.1
Respiratory disease	0.0	0.0	0.1	0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.1	0.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.1	0.0
Sitting height	0.0	0.1	0.1	-0.3	-0.3
Number of incorrect matches in round	0.0	0.1	0.1	0.3	0.2
Falls in the last year	0.0	0.0	0.0	0.0	-0.1
Noisy workplace	0.0	0.0	0.0	0.2	0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.2	-0.1
Migraine (self-reported)	0.0	0.1	0.1	-0.0	0.3
Number of full sisters	0.0	0.0	0.0	-0.1	-0.1
Chest pain or discomfort	0.0	0.0	0.0	-0.1	0.1
Mood swings	0.0	0.1	0.1	0.4	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.2	-0.2

Hub : Genes

CDCA5

Models

Trait associations