Best TWAS P=5.19e-25 · Best GWAS P=3.71e-28 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RER1 | 0.06 | 0.00 | blup | 359 | 0.01 | 8.1e-03 | 1.88 | -8.8 | 1.1e-18 | -0.28 | 0.04 | 0.16 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | TNFRSF14 | 0.05 | 0.00 | blup | 372 | 0.02 | 1.5e-03 | 10.06 | 8.3 | 1.3e-16 | 0.39 | 0.07 | 0.14 | FALSE |
3 | GTEx | Adipose Subcutaneous | C1orf86 | 0.15 | 0.05 | enet | 10 | 0.04 | 2.0e-04 | -7.84 | -6.4 | 1.7e-10 | -0.37 | 0.43 | 0.03 | TRUE |
4 | GTEx | Adipose Subcutaneous | RP11-181G12.2 | 0.09 | 0.07 | lasso | 1 | 0.05 | 1.3e-04 | -7.84 | 7.8 | 4.5e-15 | 0.47 | 0.50 | 0.34 | FALSE |
5 | GTEx | Adipose Visceral Omentum | RP11-345P4.6 | 0.40 | 0.24 | enet | 28 | 0.20 | 1.8e-10 | 3.94 | 7.5 | 8.6e-14 | 0.19 | 1.00 | 0.00 | TRUE |
6 | GTEx | Artery Aorta | RP11-181G12.2 | 0.12 | 0.04 | enet | 12 | 0.05 | 6.3e-04 | 9.61 | 7.7 | 1.4e-14 | 0.44 | 0.26 | 0.33 | FALSE |
7 | GTEx | Artery Aorta | RP11-54O7.17 | 0.28 | 0.28 | lasso | 3 | 0.30 | 3.8e-17 | 5.75 | -5.5 | 3.9e-08 | 0.01 | 0.02 | 0.98 | FALSE |
8 | GTEx | Artery Tibial | RP11-181G12.2 | 0.09 | 0.02 | enet | 37 | 0.03 | 2.8e-03 | -7.84 | 6.4 | 2.0e-10 | 0.41 | 0.06 | 0.59 | TRUE |
9 | GTEx | Brain Cerebellum | C1orf86 | 0.26 | 0.18 | lasso | 5 | 0.16 | 1.4e-05 | -7.84 | -5.8 | 7.1e-09 | -0.44 | 0.09 | 0.07 | FALSE |
10 | GTEx | Brain Cortex | PLCH2 | 0.27 | 0.03 | enet | 17 | 0.04 | 2.6e-02 | -0.61 | -6.4 | 1.8e-10 | -0.38 | 0.04 | 0.28 | TRUE |
11 | GTEx | Breast Mammary Tissue (Male) | ATAD3C | 0.14 | -0.01 | enet | 35 | 0.01 | 1.7e-01 | 5.49 | -5.6 | 1.8e-08 | 0.02 | 0.03 | 0.10 | FALSE |
12 | GTEx | Breast Mammary Tissue (Female) | B3GALT6 | 0.19 | 0.16 | lasso | 5 | 0.12 | 2.2e-04 | 5.53 | -5.5 | 3.2e-08 | 0.02 | 0.04 | 0.37 | FALSE |
13 | GTEx | Breast Mammary Tissue (Female) | SLC35E2B | 0.11 | 0.01 | enet | 22 | 0.09 | 9.1e-04 | -1.39 | 5.5 | 3.6e-08 | 0.34 | 0.03 | 0.28 | FALSE |
14 | GTEx | Breast Mammary Tissue (Female) | MRPL20 | 0.18 | -0.01 | enet | 10 | 0.00 | 4.5e-01 | 5.53 | 6.0 | 2.5e-09 | -0.03 | 0.03 | 0.14 | TRUE |
15 | GTEx | Cells Transformed fibroblasts | AGRN | 0.12 | 0.01 | enet | 15 | 0.05 | 2.0e-04 | -1.85 | -6.5 | 1.1e-10 | 0.02 | 0.01 | 0.74 | TRUE |
16 | GTEx | Cells Transformed fibroblasts | MRPL20 | 0.12 | 0.11 | lasso | 2 | 0.08 | 8.0e-07 | 5.83 | 5.9 | 4.4e-09 | -0.08 | 0.02 | 0.98 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | RP11-54O7.14 | 0.13 | 0.02 | enet | 13 | 0.05 | 1.5e-04 | -3.82 | -5.8 | 7.4e-09 | 0.00 | 0.01 | 0.82 | FALSE |
18 | GTEx | Esophagus Gastroesophageal Junction | RP11-181G12.2 | 0.16 | 0.02 | enet | 18 | 0.01 | 1.1e-01 | 10.03 | 10.3 | 5.2e-25 | 0.62 | 0.07 | 0.42 | TRUE |
19 | GTEx | Esophagus Mucosa | RP11-54O7.17 | 0.16 | 0.17 | lasso | 4 | 0.16 | 1.3e-10 | 5.75 | -5.8 | 6.9e-09 | 0.00 | 0.02 | 0.98 | FALSE |
20 | GTEx | Esophagus Muscularis | RP11-181G12.2 | 0.23 | 0.14 | lasso | 4 | 0.19 | 1.0e-11 | 9.61 | 10.2 | 1.6e-24 | 0.61 | 0.96 | 0.04 | FALSE |
21 | GTEx | Heart Left Ventricle | CEP104 | 0.19 | 0.04 | lasso | 4 | 0.05 | 1.2e-03 | 4.14 | -5.5 | 3.2e-08 | -0.07 | 0.18 | 0.07 | TRUE |
22 | GTEx | Lung | AL590822.2 | 0.09 | 0.00 | lasso | 3 | 0.00 | 2.0e-01 | 7.92 | 9.4 | 3.8e-21 | 0.53 | 0.07 | 0.23 | TRUE |
23 | GTEx | Lung | RP11-54O7.17 | 0.10 | 0.13 | lasso | 2 | 0.11 | 5.9e-09 | 5.75 | -5.6 | 2.3e-08 | 0.00 | 0.02 | 0.98 | FALSE |
24 | GTEx | Muscle Skeletal | C1orf86 | 0.20 | 0.16 | lasso | 4 | 0.15 | 8.0e-15 | -7.84 | -7.9 | 3.9e-15 | -0.47 | 1.00 | 0.00 | FALSE |
25 | GTEx | Muscle Skeletal | RP11-181G12.2 | 0.12 | 0.13 | enet | 8 | 0.14 | 7.6e-14 | -7.84 | 8.7 | 3.8e-18 | 0.57 | 1.00 | 0.00 | FALSE |
26 | GTEx | Nerve Tibial | RP11-181G12.2 | 0.24 | 0.22 | lasso | 5 | 0.21 | 3.7e-15 | -7.84 | 8.1 | 6.7e-16 | 0.49 | 1.00 | 0.00 | FALSE |
27 | GTEx | Nerve Tibial | RP11-54O7.17 | 0.16 | 0.16 | lasso | 3 | 0.15 | 7.3e-11 | 5.75 | -5.7 | 1.1e-08 | 0.01 | 0.02 | 0.98 | FALSE |
28 | GTEx | Pancreas | MRPL20 | 0.28 | 0.21 | lasso | 2 | 0.20 | 1.2e-08 | 5.83 | 5.8 | 5.1e-09 | -0.08 | 0.01 | 0.98 | FALSE |
29 | GTEx | Pancreas | RP11-54O7.17 | 0.24 | 0.22 | lasso | 3 | 0.18 | 2.9e-08 | 5.75 | -5.7 | 9.7e-09 | 0.00 | 0.02 | 0.98 | FALSE |
30 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-54O7.17 | 0.23 | 0.10 | enet | 16 | 0.14 | 3.1e-08 | 3.68 | -5.9 | 2.9e-09 | 0.02 | 0.29 | 0.70 | FALSE |
31 | GTEx | Testis | C1orf86 | 0.34 | 0.23 | enet | 16 | 0.19 | 1.2e-08 | -7.84 | -6.8 | 1.2e-11 | -0.46 | 0.99 | 0.00 | FALSE |
32 | GTEx | Thyroid | PRKCZ | 0.16 | 0.03 | lasso | 4 | 0.08 | 1.9e-06 | -7.20 | -9.8 | 1.7e-22 | -0.44 | 0.28 | 0.04 | FALSE |
33 | GTEx | Thyroid | FAM213B | 0.10 | 0.00 | enet | 36 | 0.00 | 7.9e-01 | -1.01 | -6.3 | 3.4e-10 | -0.04 | 0.11 | 0.03 | FALSE |
34 | GTEx | Thyroid | RP11-181G12.2 | 0.21 | 0.05 | enet | 54 | 0.08 | 1.7e-06 | 7.96 | -6.8 | 9.7e-12 | -0.28 | 0.10 | 0.04 | FALSE |
35 | GTEx | Thyroid | RP11-54O7.17 | 0.25 | 0.19 | enet | 15 | 0.18 | 4.0e-14 | 5.73 | -5.3 | 8.7e-08 | 0.00 | 0.02 | 0.98 | FALSE |
36 | METSIM | Adipose | B3GALT6 | 0.15 | 0.14 | bslmm | 227 | 0.14 | 1.2e-19 | 3.79 | -5.2 | 2.0e-07 | 0.02 | 0.89 | 0.11 | FALSE |
37 | METSIM | Adipose | MRPL20 | 0.13 | 0.11 | lasso | 5 | 0.10 | 9.7e-15 | 5.83 | 5.8 | 6.9e-09 | -0.08 | 0.01 | 0.99 | FALSE |
38 | METSIM | Adipose | TNFRSF14 | 0.07 | 0.05 | blup | 373 | 0.05 | 1.9e-07 | 0.91 | 6.5 | 7.1e-11 | 0.30 | 0.97 | 0.02 | TRUE |
39 | METSIM | Adipose | TNFRSF18 | 0.09 | 0.10 | lasso | 7 | 0.09 | 1.8e-13 | 4.83 | -5.3 | 1.3e-07 | 0.03 | 0.81 | 0.19 | FALSE |
40 | ROSMAP | Brain Pre-frontal Cortex | SSU72 | 0.05 | 0.01 | blup | 277 | 0.02 | 3.1e-03 | 4.49 | 5.7 | 1.6e-08 | 0.01 | 0.06 | 0.41 | FALSE |
41 | ROSMAP | Brain Pre-frontal Cortex | PUSL1 | 0.10 | 0.06 | lasso | 3 | 0.06 | 9.9e-08 | 5.67 | -5.6 | 2.3e-08 | 0.08 | 0.07 | 0.93 | FALSE |
42 | ROSMAP | Brain Pre-frontal Cortex | B3GALT6 | 0.04 | 0.02 | lasso | 3 | 0.02 | 7.8e-04 | 4.27 | -5.5 | 2.8e-08 | 0.01 | 0.05 | 0.91 | FALSE |
43 | ROSMAP | Brain Pre-frontal Cortex | MRPL20 | 0.16 | 0.15 | enet | 9 | 0.16 | 7.4e-20 | 5.67 | 5.8 | 6.7e-09 | -0.07 | 0.04 | 0.96 | FALSE |
44 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C1orf86 | 0.03 | 0.02 | blup | 49 | 0.01 | 1.3e-02 | 10.05 | 9.1 | 7.9e-20 | 0.60 | 0.07 | 0.27 | TRUE |
45 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C1orf86 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.5e-03 | 10.05 | 8.0 | 1.1e-15 | 0.53 | 0.06 | 0.17 | FALSE |
46 | The Cancer Genome Atlas | Thyroid Carcinoma | AGRN | 0.05 | 0.00 | blup | 40 | 0.03 | 1.5e-03 | 5.73 | -6.3 | 2.6e-10 | 0.00 | 0.00 | 0.81 | FALSE |
47 | The Cancer Genome Atlas | Thyroid Carcinoma | PRKCZ | 0.12 | 0.03 | enet | 6 | 0.02 | 9.0e-03 | 8.00 | -7.7 | 1.0e-14 | -0.26 | 0.57 | 0.06 | FALSE |