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chr5:110,301,225-113,515,807

Best TWAS P=6.71e-23 · Best GWAS P=9.41e-24 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	REEP5	0.09	0.03	lasso	9	0.08	1.7e-09	0.43	6.2	4.9e-10	0.66	0.07	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SRP19	0.08	0.06	lasso	5	0.07	1.3e-08	6.94	-7.2	7.8e-13	-0.72	0.88	0.12	FALSE
3	GTEx	Adipose Subcutaneous	REEP5	0.10	0.09	lasso	2	0.05	2.8e-05	5.40	6.0	1.5e-09	0.68	0.63	0.34	FALSE
4	GTEx	Adipose Subcutaneous	DCP2	0.21	0.11	enet	16	0.15	3.4e-12	-6.93	-6.5	1.0e-10	-0.18	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	REEP5	0.09	0.05	lasso	5	0.02	4.9e-02	6.68	6.5	8.5e-11	0.72	0.22	0.42	FALSE
6	GTEx	Adipose Visceral Omentum	MCC	0.14	0.09	enet	6	0.07	1.5e-04	5.54	5.2	2.4e-07	0.15	0.50	0.05	FALSE
7	GTEx	Artery Aorta	REEP5	0.17	0.07	lasso	13	0.10	4.2e-06	9.39	8.8	1.7e-18	0.90	0.19	0.81	FALSE
8	GTEx	Artery Aorta	MCC	0.19	0.18	lasso	7	0.16	5.8e-09	6.55	6.3	3.6e-10	0.18	1.00	0.00	FALSE
9	GTEx	Artery Tibial	REEP5	0.17	0.12	lasso	5	0.13	3.0e-10	6.73	6.1	1.4e-09	0.66	0.99	0.01	FALSE
10	GTEx	Artery Tibial	DCP2	0.14	0.07	lasso	3	0.07	2.9e-06	-7.06	-7.0	2.3e-12	-0.17	0.94	0.01	TRUE
11	GTEx	Breast Mammary Tissue	MCC	0.30	0.17	enet	6	0.12	1.4e-06	5.46	5.2	1.7e-07	0.17	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	CTC-487M23.5	0.07	0.03	lasso	3	0.03	2.9e-03	-8.60	-9.9	6.7e-23	-0.88	0.05	0.84	TRUE
13	GTEx	Colon Sigmoid	MCC	0.18	0.08	enet	18	0.10	1.5e-04	6.55	5.5	3.1e-08	0.21	0.22	0.24	FALSE
14	GTEx	Colon Transverse	REEP5	0.12	0.14	lasso	2	0.14	4.4e-07	6.77	7.0	3.6e-12	0.75	0.80	0.15	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	REEP5	0.18	0.03	lasso	3	0.03	3.7e-02	7.50	7.5	7.6e-14	0.82	0.04	0.88	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	DCP2	0.21	0.06	enet	12	0.12	3.1e-05	-6.93	-5.9	4.2e-09	-0.12	0.86	0.01	FALSE
17	GTEx	Esophagus Mucosa	REEP5	0.19	0.10	lasso	5	0.09	1.5e-06	7.50	7.6	3.7e-14	0.78	0.12	0.84	FALSE
18	GTEx	Esophagus Mucosa	MCC	0.29	0.21	lasso	5	0.20	3.8e-13	5.54	5.4	5.1e-08	0.14	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	REEP5	0.18	0.09	lasso	4	0.14	5.9e-09	6.77	6.7	1.8e-11	0.79	0.33	0.67	FALSE
20	GTEx	Esophagus Muscularis	DCP2	0.18	0.16	lasso	6	0.15	2.0e-09	5.95	-6.1	9.8e-10	-0.18	1.00	0.00	FALSE
21	GTEx	Lung	DCP2	0.08	0.02	enet	12	0.02	8.9e-03	6.32	-8.3	1.0e-16	-0.30	0.31	0.09	FALSE
22	GTEx	Nerve Tibial	REEP5	0.16	0.13	lasso	3	0.10	9.2e-08	6.73	6.9	4.2e-12	0.68	0.96	0.03	FALSE
23	GTEx	Nerve Tibial	DCP2	0.36	0.27	enet	24	0.26	7.2e-19	6.32	-6.2	7.6e-10	-0.14	1.00	0.00	FALSE
24	GTEx	Nerve Tibial	XBP1P1	0.06	0.05	lasso	2	0.04	6.1e-04	6.01	7.6	2.0e-14	0.87	0.17	0.70	FALSE
25	GTEx	Pancreas	DCP2	0.22	0.18	enet	16	0.11	2.3e-05	3.77	-5.8	7.8e-09	-0.08	0.93	0.01	FALSE
26	GTEx	Pituitary	REEP5	0.19	0.02	enet	16	0.02	1.1e-01	6.66	5.1	2.9e-07	0.53	0.07	0.45	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	REEP5	0.11	0.10	lasso	7	0.10	6.3e-06	5.40	6.3	3.4e-10	0.68	0.37	0.59	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	MCC	0.21	0.06	lasso	6	0.06	4.7e-04	5.72	6.0	1.8e-09	0.16	0.58	0.02	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	DCP2	0.20	0.15	lasso	3	0.16	6.3e-09	6.32	-6.4	1.6e-10	-0.15	1.00	0.00	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.5	0.10	0.06	lasso	3	0.05	6.7e-04	6.69	8.0	1.7e-15	0.77	0.04	0.90	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.7	0.08	0.09	enet	7	0.10	3.9e-06	6.72	7.9	3.6e-15	0.84	0.04	0.95	FALSE
32	GTEx	Skin Sun Exposed Lower leg	REEP5	0.08	0.05	lasso	4	0.03	1.9e-03	5.40	6.1	9.5e-10	0.73	0.55	0.39	FALSE
33	GTEx	Skin Sun Exposed Lower leg	MCC	0.18	0.14	enet	12	0.11	2.0e-09	5.72	6.5	8.5e-11	0.19	1.00	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	DCP2	0.18	0.12	enet	20	0.16	5.4e-13	6.55	-5.7	1.4e-08	-0.08	1.00	0.00	TRUE
35	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.5	0.17	0.07	lasso	6	0.06	7.7e-06	6.90	7.4	1.1e-13	0.72	0.59	0.41	FALSE
36	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.7	0.06	0.07	lasso	1	0.04	2.4e-04	6.90	6.9	5.3e-12	0.67	0.40	0.46	FALSE
37	GTEx	Spleen	DCP2	0.52	0.19	enet	22	0.13	4.0e-04	5.77	-7.0	3.2e-12	-0.22	0.52	0.03	FALSE
38	GTEx	Testis	REEP5	0.22	0.14	lasso	5	0.14	6.6e-07	6.77	8.1	6.9e-16	0.80	0.27	0.69	FALSE
39	GTEx	Testis	MCC	0.33	0.26	lasso	4	0.22	3.5e-10	5.46	5.6	2.1e-08	0.15	1.00	0.00	TRUE
40	GTEx	Thyroid	DCP2	0.19	0.19	lasso	2	0.19	2.2e-14	-6.93	-6.9	5.0e-12	-0.20	1.00	0.00	TRUE
41	GTEx	Uterus	REEP5	0.39	0.05	lasso	8	0.10	5.0e-03	1.18	6.7	2.1e-11	0.58	0.08	0.38	TRUE
42	METSIM	Adipose	APC	0.03	0.00	bslmm	520	0.01	1.7e-02	8.85	5.4	7.4e-08	0.32	0.10	0.32	FALSE
43	METSIM	Adipose	DCP2	0.06	0.05	lasso	5	0.06	5.5e-09	-7.06	-6.5	6.6e-11	-0.16	1.00	0.00	FALSE
44	METSIM	Adipose	MCC	0.08	0.06	lasso	13	0.04	9.9e-07	-6.92	6.7	1.6e-11	0.25	1.00	0.00	FALSE
45	METSIM	Adipose	REEP5	0.05	0.00	bslmm	475	0.01	6.8e-03	6.80	5.9	2.7e-09	0.62	0.40	0.40	FALSE
46	NTR	Blood	MCC	0.03	0.02	lasso	2	0.02	3.4e-07	-6.99	6.9	6.1e-12	0.21	1.00	0.00	FALSE
47	NTR	Blood	REEP5	0.03	0.04	lasso	9	0.04	3.3e-12	9.39	9.7	3.0e-22	0.86	0.40	0.60	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	REEP5	0.08	0.03	lasso	3	0.02	1.3e-03	-8.48	7.9	3.8e-15	0.56	0.20	0.43	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	NREP	0.06	0.01	enet	18	0.02	3.8e-04	-2.95	5.8	6.2e-09	0.11	0.19	0.36	TRUE
50	ROSMAP	Brain Pre-frontal Cortex	DCP2	0.06	0.01	bslmm	495	0.02	6.1e-04	3.77	5.8	5.7e-09	0.30	0.73	0.04	FALSE
51	YFS	Blood	DCP2	0.12	0.16	bslmm	485	0.16	7.4e-51	-7.06	-5.7	1.2e-08	-0.14	1.00	0.00	FALSE
52	YFS	Blood	REEP5	0.09	0.04	blup	462	0.06	7.5e-20	-8.48	6.8	7.7e-12	0.40	0.97	0.03	FALSE
53	YFS	Blood	SRP19	0.02	0.01	bslmm	456	0.00	2.9e-02	8.61	7.3	3.0e-13	0.66	0.04	0.77	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	APC	0.04	0.02	blup	75	0.02	4.8e-03	6.73	5.5	3.1e-08	0.55	0.08	0.29	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APC	0.03	0.02	blup	77	0.02	5.2e-03	8.63	6.5	7.9e-11	0.36	0.03	0.23	TRUE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCP2	0.02	0.02	lasso	3	0.01	1.1e-02	6.32	-6.4	1.3e-10	-0.15	0.02	0.94	TRUE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRP19	0.05	0.04	lasso	3	0.04	3.7e-05	6.72	-7.0	2.0e-12	-0.72	0.81	0.10	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSSK1B	0.04	0.02	enet	8	0.03	3.6e-04	-5.48	-5.5	3.6e-08	-0.09	0.00	0.95	TRUE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCP2	0.05	0.01	blup	82	0.04	6.3e-05	4.73	-5.6	2.7e-08	-0.25	0.02	0.83	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRP19	0.05	0.05	lasso	1	0.05	4.5e-06	6.41	-6.4	1.4e-10	-0.81	0.43	0.46	FALSE
61	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRP19	0.07	0.03	lasso	4	0.02	2.4e-02	6.41	-6.3	2.4e-10	-0.80	0.05	0.35	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	REEP5	0.03	0.02	blup	47	0.03	4.1e-03	5.70	7.0	2.8e-12	0.79	0.05	0.23	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	APC	0.02	0.02	enet	5	0.02	4.2e-03	-9.33	9.6	7.8e-22	0.95	0.03	0.87	FALSE