Hub : Genes

CALU

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0270	9.1e-04	0.026	0.018	0.021	0.021	0.022	3.7e-04	2.2e-03	1.3e-03	1.2e-03	8.5e-04
2	GTEx	Cells Transformed fibroblasts	0.2470	0.0520	1.3e-08	0.230	NA	0.195	NA	0.074	3.5e-17	NA	1.5e-14	NA	3.2e-06
3	GTEx	Esophagus Muscularis	0.1290	0.0490	1.5e-03	0.099	NA	0.104	NA	-0.005	1.4e-06	NA	6.9e-07	NA	9.5e-01
4	GTEx	Muscle Skeletal	0.1242	0.0347	8.6e-06	0.047	NA	0.015	NA	0.023	2.1e-05	NA	1.0e-02	NA	2.1e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0932	0.0258	3.0e-07	0.099	0.053	0.091	0.080	0.094	1.0e-12	2.3e-07	1.0e-11	1.9e-10	3.9e-12
6	TCGA	Colon Adenocarcinoma	0.1340	0.0620	9.3e-04	0.030	0.063	0.069	NA	0.046	7.7e-03	1.6e-04	7.7e-05	NA	1.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.2	3.4	6.2	-2.1	-1.3	-1.5	-2.4	2.5	-0.5
Bipolar Disorder or Schizophrenia	2.3	5.5	9.3	-3.0	-1.6	-0.9	-2.7	3.0	-2.0
Depressed Affect (Nagel 2018)	2.1	4.5	6.9	-2.2	-2.6	-2.1	-1.9	2.1	-1.5
Depression (Nagel 2018)	1.9	2.9	6.8	-2.1	-1.4	-0.1	-0.7	1.9	-2.6
Intelligence (Savage-Jansen 2018)	4.3	13.3	19.5	4.4	3.7	1.4	3.9	-4.0	3.7
Neuroticism (Nagel 2018)	3.6	8.5	11.2	-3.1	-3.0	-3.0	-3.0	3.4	-1.8
Schizophrenia (2018)	1.3	2.6	4.7	-2.2	-1.0	0.1	-1.5	1.9	-2.0
Schizophrenia vs Biploar Disorder	1.4	1.8	5.0	-1.5	-0.8	0.1	-0.9	1.5	-2.2
Worry (Nagel 2018)	3.2	6.7	8.7	-2.7	-2.3	-2.7	-2.9	2.9	-1.6
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.1	0.9	1.3	1.0	-1.0	1.1
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-0.8	0.7	0.6	-1.1	1.2	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.1	0.8	1.4	1.8	0.5	-0.3	1.2
Crohns Disease (2017)	1.3	2.8	4.1	-1.6	-2.0	-1.9	-1.5	1.6	1.4
Irritable Bowel Disease (IBD)	2.2	5.3	7.5	-2.4	-2.6	-2.4	-2.4	2.7	-0.2
Ulcerative Colitis (UC)	1.6	3.1	4.5	-1.5	-1.7	-1.4	-1.9	2.1	-1.8
Major Depression (MDD)	1.3	1.5	3.2	1.8	1.6	1.0	0.9	-1.1	0.8
Reaction Time	1.0	2.0	5.2	-1.7	-0.9	-0.8	-2.3	1.5	-0.4
Verbal and Numeric Reasoning (VNR)	3.1	7.5	11.5	3.2	2.6	0.6	2.9	-2.8	3.4
Breast Cancer	0.4	0.9	2.5	0.7	1.0	1.2	-0.4	-0.4	1.6
Ovarian Cancer	1.1	1.5	3.6	-0.6	-1.2	-1.9	-1.5	1.1	0.3
Prostate Cancer	0.3	0.4	1.5	1.2	0.6	0.5	-0.1	-0.5	-0.0
Age at First Birth	0.8	1.2	2.0	0.8	1.4	1.4	0.6	-0.9	-1.1
Bipolar Disorder (2011)	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.0	0.5
Body Mass Index (BMI) (2010)	0.3	0.5	0.9	-0.6	-0.7	-1.0	-0.7	0.7	0.1
Coronary Artery Disease (CAD)	0.5	0.6	1.8	-0.2	-1.1	-1.3	0.0	0.5	-0.2
Crohns Disease (2012)	0.6	0.9	4.0	0.1	-0.8	-0.9	0.3	0.2	2.0
Mean Putamen Volume	0.5	0.5	1.3	1.2	0.9	0.6	-0.2	-0.8	0.1
Fasting Glucose	0.5	0.6	0.9	0.8	-0.6	-0.3	0.8	-0.9	0.9
HbA1C	1.9	2.1	3.6	-1.0	-1.6	-1.9	-1.6	1.7	-0.3
HDL Cholesterol	0.1	0.2	0.5	-0.0	-0.7	-0.4	0.4	-0.3	0.4
LDL Cholesterol	1.1	1.8	2.7	1.5	1.6	1.6	0.8	-1.6	-0.3
Lupus	3.8	5.7	14.2	-2.3	-1.6	-1.5	-3.8	2.5	-1.9
Neuroticism (2016)	3.5	5.1	8.6	-1.8	-2.9	-2.2	-2.6	2.0	-1.6
Primary Biliary Cirrhosis	3.9	5.6	11.0	-2.6	-1.8	-1.2	-3.3	3.1	-1.1
Rheumatoid Arthritis	0.5	0.7	1.4	-0.5	0.0	-1.2	-1.2	0.6	0.9
Schizophrenia (2014)	1.1	2.3	4.4	-2.1	-0.3	0.6	-1.2	2.1	-1.9
Triglycerides	1.2	2.0	3.6	1.9	1.5	1.8	1.0	-1.4	0.5
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	-0.1	0.0	0.4	0.4	0.1	-0.1
Ulcerative Colitis	4.2	6.1	8.8	-2.3	-2.5	-1.8	-3.0	2.9	-2.1
Blood Eosinophil Count	0.0	0.2	1.0	-0.3	-0.3	1.0	-0.3	0.2	-0.3
Blood Platelet Count	0.1	1.6	4.2	-0.6	-2.1	-2.0	-0.3	0.6	-0.6
Blood Red Count	0.1	1.3	5.8	0.9	0.7	0.5	-0.1	-0.6	2.4
Blood White Count	0.1	0.4	1.0	-0.7	-0.9	0.1	-0.5	1.0	-0.2
Heel T-Score	0.7	5.6	14.2	-3.8	-1.7	-2.0	-1.9	2.9	-0.7
BMI	0.1	0.5	2.1	0.6	0.0	-0.2	-0.0	-0.6	1.5
Height	0.9	17.3	28.8	-4.1	-5.4	-4.9	-3.3	4.8	0.1
Waist Hip Ratio (WHR)	2.9	13.1	27.6	-2.5	-4.8	-5.2	-2.5	3.9	-0.5
Systolic Blood Pressure	1.4	6.9	11.0	-3.2	-2.4	-0.6	-2.3	3.0	-3.3
Smoking Status	0.3	0.7	2.1	-0.5	-1.4	-0.9	0.1	0.9	0.2
Allergy or Eczema	0.3	0.7	2.1	-0.4	-1.5	-1.2	-0.0	0.0	-0.6
Cardiovascular Disease	1.6	5.2	7.8	-2.4	-2.8	-2.1	-2.2	2.4	-1.5
Hypothyroidism (self reported)	0.6	1.5	4.7	-1.2	-0.3	-1.2	-2.2	1.0	0.0
Respiratory disease	0.5	1.0	2.1	-0.9	-1.3	-1.5	-0.5	1.1	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.9	-0.5	0.6	1.0	-0.2	0.9	1.4
Lung FEV1/FVC ratio	0.9	4.7	8.5	2.6	2.1	2.2	1.7	-2.9	0.6
Lung FVC	0.1	0.3	0.6	-0.6	0.7	0.3	-0.8	0.4	0.1
Neuroticism	3.6	8.7	12.5	-2.8	-3.5	-3.4	-2.7	3.4	-0.8
Chronotype (morning person)	0.5	1.2	5.5	-0.3	-1.0	-2.3	-0.6	-0.3	0.2
Hair Pigment	0.2	4.5	6.0	2.2	2.3	2.4	1.6	-2.1	2.0
Tanning	0.0	0.3	0.6	-0.8	-0.7	-0.2	-0.2	0.5	-0.6
Hand grip strength (left)	3.2	8.6	12.1	-3.4	-2.9	-3.1	-3.1	3.5	-0.3
Number of treatments/medications taken	0.9	1.6	3.9	-2.0	-0.9	-1.0	-1.3	1.5	-0.2
Average weekly spirits intake	6.8	8.5	12.7	-3.6	-2.9	-2.9	-3.0	3.4	-0.7
Sensitivity / hurt feelings	1.6	2.8	4.2	-1.6	-1.8	-1.5	-2.1	2.0	-0.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	5.3	-1.0	-0.3	0.5	-0.8	1.0	-2.3
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.5	0.7	0.5	0.1	-0.5	-0.7
Relative age of first facial hair	0.7	1.5	5.0	1.5	0.4	0.0	0.8	-1.1	2.2
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	4.6	-2.1	-1.5	-1.9	-1.7	2.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	1.2	0.2	0.0	0.1	-0.5	0.6
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	0.6	0.1	0.2	0.9	-0.5	0.2
Systolic blood pressure, automated reading	0.5	1.6	3.5	-1.7	-0.9	0.4	-0.6	1.3	-1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.4	-0.8	-0.4	-0.0	0.2	-0.2
Angina	3.8	4.9	10.8	-3.3	-1.8	-0.5	-2.3	2.6	-1.7
Medication for hormone replacement therapy	1.1	1.2	3.7	0.2	-0.4	-1.9	0.2	0.0	1.8
Vitamin and mineral supplements	0.9	1.2	3.0	1.1	-0.2	-1.7	-0.0	-0.5	1.7
Supplements: Zinc	0.6	0.6	1.8	0.1	0.6	0.8	1.4	-1.0	-0.2
Medication: Co-codamol	0.2	0.2	0.7	0.0	0.1	-0.6	-0.8	0.3	0.1
Medication: Metformin	0.2	0.3	1.2	-0.2	-0.1	0.8	0.1	0.1	-1.1
Diabetes (father)	1.8	2.3	4.5	-1.5	-2.1	-1.8	-1.2	1.5	-0.3
Diabetes (mother)	1.3	1.6	4.8	-1.0	-2.2	-1.9	0.4	0.5	0.1
Severe depression (siblings)	0.1	0.1	0.6	0.0	0.3	-0.1	-0.3	0.0	0.8
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	0.2	0.1	0.0	-0.4	0.7
Impedance of leg (right)	0.1	0.7	2.5	-0.1	0.2	-0.6	0.2	1.0	1.6
Leg fat-free mass (left)	0.3	1.5	3.7	-0.8	-1.8	-1.9	-0.9	0.8	-0.0
Trunk fat percentage	0.7	2.8	4.8	-1.8	-2.0	-2.2	-1.5	1.6	-0.2
Hand grip strength (right)	3.4	9.2	16.0	-3.1	-3.2	-4.0	-2.7	3.5	-0.4
Townsend deprivation index at recruitment	0.3	0.5	1.2	-0.3	-0.1	0.7	-1.1	0.4	-0.9
Current tobacco smoking	0.5	0.8	1.9	-0.9	-0.1	0.7	-0.4	1.2	-1.4
Average weekly fortified wine intake	3.9	4.6	6.7	2.6	1.8	1.4	2.3	-2.3	2.2
Maternal smoking around birth	3.6	5.2	6.9	-2.1	-2.5	-2.6	-2.3	2.5	-1.3
Fed-up feelings	0.7	1.2	2.0	-1.4	-0.7	-0.5	-1.3	1.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	4.0	-1.4	-1.1	-0.3	-1.0	1.5	-2.0
Relative age voice broke	0.2	0.3	1.4	0.2	-0.2	-1.2	-0.3	0.0	0.6
Taking other prescription medications	1.1	1.7	4.1	-2.0	-1.3	-1.3	-0.3	1.2	-1.1
Age when periods started (menarche)	0.6	1.4	3.2	1.2	-0.1	0.0	1.8	-1.1	1.6
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	5.7	2.4	1.9	2.2	0.9	-1.8	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.4	5.5	9.0	-3.0	-1.8	-1.4	-3.0	2.8	-1.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.6	0.1	-0.0	0.2	0.2	-0.3
Qualifications: CSEs or equivalent	3.1	4.1	7.0	-2.6	-1.8	-1.4	-2.4	2.6	0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.5	0.5	0.8	0.9	0.3	0.5
High blood pressure	0.5	1.3	2.8	-1.4	-1.7	-0.3	-0.4	0.9	-1.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	-0.3	-0.9	-0.9	0.0	-0.1	-0.3
Multivitamins +/- minerals	0.6	0.8	1.8	-1.1	0.4	1.3	-0.5	0.6	-1.0
Stomach or abdominal pain in last month	2.7	3.4	4.9	-2.1	-2.2	-1.8	-1.5	2.2	-0.9
Supplements: Glucosamine	1.7	2.2	4.0	1.2	2.0	1.2	0.8	-1.3	2.0
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.2	1.3	2.3	1.3	-0.2	-1.6	0.3
Medication: Atenolol	1.0	1.3	6.0	-0.1	0.9	2.4	-0.6	-0.1	-0.8
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.4	0.4	-0.8	-0.5	0.3	0.0
Sitting height	0.5	3.9	7.2	-1.6	-2.6	-2.7	-1.4	2.1	-0.1
Chronic bronchitis/emphysema (father)	1.6	1.9	3.0	-1.7	-1.2	-0.5	-1.5	1.7	-1.1
High blood pressure (mother)	0.3	0.4	1.4	-0.2	0.2	0.2	0.6	-0.5	1.2
Body mass index (BMI)	0.0	0.2	0.7	0.4	0.4	0.3	0.3	-0.8	0.3
Impedance of leg (left)	0.2	1.0	2.3	-0.7	-0.2	-0.9	-0.4	1.5	1.5
Leg predicted mass (left)	0.3	1.7	4.0	-0.9	-1.9	-2.0	-1.0	0.9	-0.1
Trunk fat mass	0.7	3.0	6.5	-1.6	-2.1	-2.5	-1.4	1.5	0.1
Waist circumference	0.6	2.0	5.1	-0.9	-1.8	-2.3	-1.2	1.2	0.3
Number of incorrect matches in round	3.4	5.6	12.4	-2.5	-2.7	-1.9	-0.9	1.7	-3.5
Past tobacco smoking	1.0	1.9	3.4	1.2	1.8	1.7	0.9	-1.6	-0.5
Alcohol usually taken with meals	1.3	2.1	3.9	1.4	0.8	0.9	2.0	-1.9	1.3
Nervous feelings	2.5	4.8	6.9	-2.6	-1.9	-1.8	-2.0	2.3	-2.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.6	-1.5	-0.9	-0.5	-0.3	1.2	-2.1
Hearing difficulty/problems with background noise	0.5	0.7	1.4	-0.3	-1.2	-1.1	-1.2	0.6	-0.3
Hair/balding pattern: Pattern 2	1.0	1.3	4.2	0.4	2.1	1.4	0.4	-0.9	-0.6
Had menopause	0.3	0.4	1.5	-0.1	-0.7	-0.1	0.2	-0.3	-1.2
Had other major operations	0.3	0.3	1.2	-1.1	-0.3	-0.2	0.2	0.6	0.5
Forced vital capacity (FVC)	0.1	0.5	1.0	-0.7	-0.5	-0.1	-0.6	1.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.3	-2.1	-0.9	-0.5	-1.8	1.6	-1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	1.8	0.7	1.4	0.4	-1.1	-0.1
Qualifications: None of the above	0.9	1.9	5.0	-1.6	-1.2	-0.7	-1.1	0.8	-2.2
Financial difficulties in last 2 years	0.2	0.2	1.0	-0.3	-0.4	0.1	-0.0	0.3	-1.0
Mouth/teeth dental problems	5.7	8.7	11.3	2.7	3.2	3.2	3.4	-3.0	2.1
Heart attack	2.8	3.6	5.5	-2.3	-1.8	-0.9	-1.8	1.9	-2.3
Allergy	0.0	0.1	0.3	0.2	0.5	0.6	0.1	0.1	0.1
Pain all over the body in last month	2.8	3.0	4.7	1.5	2.2	2.1	2.0	-1.2	1.0
Diabetes (self-reported)	0.1	0.2	0.5	0.2	0.3	0.2	0.7	-0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	0.3	0.4	1.3	0.6	-0.6	-0.8
Medication: Ramipril	2.6	3.4	6.9	-2.2	-2.6	-1.3	-1.2	1.9	-1.4
Medication: Simvastatin	0.4	0.6	2.5	0.1	1.1	1.6	-0.2	0.1	0.2
Fluid intelligence score	4.3	9.0	12.0	3.4	2.9	1.3	3.1	-3.5	3.2
Illnesses of siblings	0.3	0.5	1.7	0.2	-0.4	-0.4	-0.8	0.5	1.3
Neuroticism score	2.7	5.7	7.6	-2.2	-2.6	-2.5	-2.8	2.7	-1.2
Weight	0.3	1.4	3.8	-0.8	-1.6	-1.9	-0.9	0.8	0.3
Impedance of arm (right)	1.1	5.4	8.0	-2.8	-2.5	-2.0	-2.3	2.8	-0.9
Arm fat percentage (right)	0.2	0.7	1.3	-0.8	-0.9	-1.2	-0.8	0.5	0.2
Trunk fat-free mass	0.2	1.2	3.9	0.2	-1.5	-2.0	0.1	0.1	0.8
Hip circumference	0.1	0.4	1.3	0.5	-0.0	-0.6	0.1	-0.5	1.2
Time employed in main current job	0.1	0.1	0.3	-0.2	-0.1	-0.6	0.3	-0.1	-0.3
Alcohol intake versus 10 years previously	0.9	1.4	4.0	-0.0	1.0	1.7	-0.1	-0.1	-2.0
Father’s age at death	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.2	0.1	0.5
Worrier / anxious feelings	3.2	6.0	13.0	-1.8	-2.6	-3.6	-2.7	2.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	0.5	-0.1	0.6	0.7	0.2	0.5
Falls in the last year	0.4	0.5	1.5	0.3	0.5	0.0	1.0	-1.2	-0.4
Hair/balding pattern: Pattern 3	3.6	5.3	9.8	-2.5	-2.8	-3.1	-1.5	2.3	0.6
Number of live births	0.6	0.8	3.0	-1.0	-0.7	-0.1	-0.1	0.7	-1.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.0	0.4	0.7	1.0	0.0	-0.3	0.9
Pulse rate	1.1	1.9	3.6	1.7	0.9	0.9	1.9	-1.7	0.5
Happiness	2.8	3.4	7.3	1.9	2.1	2.7	1.6	-1.1	1.0
Noisy workplace	1.4	1.7	4.0	-1.1	-1.0	-1.1	-1.6	2.0	0.3
Qualifications: A levels/AS levels or equivalent	6.1	13.4	17.4	3.6	4.2	2.4	4.0	-3.9	3.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.7	-0.8	-0.6	-1.6	-0.5	1.2	1.6
Mouth/teeth dental problems: Dentures	1.7	2.9	5.3	-2.3	-1.6	-1.1	-1.7	2.1	-1.2
Asthma	0.1	0.2	0.8	-0.0	-0.5	-0.9	0.4	0.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	0.1	0.9	0.1	-1.0	0.4	1.0
Medication: Cholesterol lowering	0.2	0.3	1.2	-0.3	0.7	1.1	0.3	0.1	-0.1
Depression (self-reported)	1.4	1.7	2.5	1.0	1.2	1.6	1.4	-1.5	-1.0
Medication: Lansoprazole	3.6	4.1	7.5	-2.7	-1.9	-1.1	-1.1	1.9	-2.7
Prospective memory result	1.7	2.1	3.9	-1.5	-2.0	-1.6	-1.2	1.2	-1.1
Lung cancer (father)	0.4	0.4	1.8	0.1	-0.5	-0.7	0.3	-0.3	-1.3
Illnesses of mother	0.1	0.1	0.5	0.7	0.5	0.1	-0.3	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	-0.7	-0.4	-0.2	-1.1	0.4	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	0.1	-0.2	-0.3	0.4	-0.1	0.8
Impedance of arm (left)	1.1	5.2	7.1	-2.5	-2.7	-2.4	-2.1	2.6	-0.8
Arm fat mass (right)	0.2	0.6	1.9	-0.6	-0.9	-1.4	-0.5	0.3	0.5
Trunk predicted mass	0.2	1.2	4.0	0.2	-1.6	-2.0	0.0	0.2	0.8
Standing height	1.2	11.6	25.8	-2.7	-4.5	-5.1	-2.4	3.3	-0.1
Length of working week for main job	5.7	6.3	8.6	2.6	2.8	2.3	2.9	-2.2	2.1
Exposure to tobacco smoke at home	0.7	0.8	1.5	-0.2	-1.2	-1.2	-1.0	0.6	0.7
Breastfed as a baby	0.3	0.3	1.4	0.4	0.4	0.3	-0.4	-0.1	1.2
Tense / ‘highly strung’	0.4	0.6	2.1	-0.6	-0.3	-1.4	-0.7	0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	0.7	0.4	1.0	0.4	-0.7	-1.0
Hair/balding pattern: Pattern 4	1.0	2.4	4.3	2.0	1.4	2.1	0.7	-1.7	-0.5
Birth weight of first child	1.1	2.0	5.5	-0.5	-2.0	-2.3	-1.3	0.8	0.3
Peak expiratory flow (PEF)	0.2	0.5	1.7	0.6	0.7	1.3	-0.1	-0.7	-0.4
Pulse wave reflection index	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	0.4	0.5	0.3	-0.1	0.3	0.9
Loud music exposure frequency	0.9	1.0	1.8	-1.0	-1.3	-1.4	-0.4	1.0	-0.5
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	6.2	2.3	1.9	1.1	2.5	-2.4	2.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	2.0	1.4	-0.5	-0.9	-0.4	-0.3	1.3
Blood clot in the leg (DVT)	0.4	0.5	1.0	0.4	1.0	0.9	-0.4	-0.2	0.7
Medication: Paracetamol	0.5	0.9	2.0	-0.9	-1.2	-0.6	-1.4	0.8	-0.2
Headache pain in last month	0.6	1.0	2.5	-1.0	-0.8	-1.6	-0.9	0.9	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	0.9	0.8	0.1	-0.1	-0.5	0.8
Glaucoma (self-reported)	1.0	1.1	2.7	0.9	0.6	1.3	1.6	-1.1	-0.1
Gout (self-reported)	0.2	0.2	0.6	0.1	0.1	0.8	0.1	-0.2	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.8	-0.8	-0.0	-1.3	-1.4	0.7	0.3
Medication: Amlodipine	0.4	0.5	1.1	-1.0	-0.2	0.1	-1.0	1.0	-0.4
Medication: Ventolin 100micrograms inhaler	1.2	1.5	6.1	1.0	-0.8	-1.2	0.3	-0.1	2.5
Birth weight	2.1	4.5	9.9	-1.8	-3.1	-3.0	-1.5	1.4	-0.5
Chronic bronchitis/emphysema (mother)	1.2	1.4	5.5	-0.5	-0.9	-2.3	-0.4	1.0	0.6
High blood pressure (siblings)	0.6	0.9	3.3	-1.0	0.3	0.6	-0.3	0.6	-1.8
Forced vital capacity (FVC), Best measure	0.8	2.8	3.7	-1.9	-1.8	-1.8	-1.9	1.8	-0.5
Body fat percentage	0.3	1.2	2.5	-1.1	-1.1	-1.6	-1.0	1.0	0.5
Leg fat percentage (right)	0.2	0.7	2.6	0.5	0.5	-0.3	0.8	-0.5	1.6
Arm fat-free mass (right)	0.2	1.1	4.1	0.0	-1.4	-2.0	-0.2	0.3	0.7
Exposure to tobacco smoke outside home	0.7	1.0	1.6	-0.9	-0.9	-1.1	-1.3	1.0	-0.7
Comparative body size at age 10	0.4	1.1	2.0	1.4	1.3	0.9	0.6	-1.4	0.3
Number of full brothers	0.4	0.5	1.8	0.5	0.6	1.4	-0.5	0.3	-0.5
Worry too long after embarrassment	0.8	1.4	2.4	-0.7	-1.4	-1.1	-1.5	1.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.0	-0.7	-0.6	-0.2	0.0	-0.7
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	0.0	0.2	-0.3	0.9	0.1	0.1
Number of children fathered	0.7	0.8	3.2	-0.4	-0.4	-1.8	-0.3	0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	4.4	5.2	11.8	-2.7	-2.5	-3.4	-1.5	1.8	-0.7
Age at first live birth	0.4	0.7	2.0	1.4	0.3	0.0	0.4	-1.2	0.7
Pulse wave peak to peak time	0.1	0.2	0.4	-0.3	-0.1	-0.1	-0.6	0.3	-0.6
Health satisfaction	0.5	0.6	1.7	-0.7	-0.3	0.7	-0.8	1.3	-0.7
Shortness of breath walking on level ground	0.4	0.5	1.0	-1.0	-0.9	-0.9	-0.3	0.5	-0.4
Qualifications: College or University degree	5.0	15.7	22.7	4.3	4.8	3.4	3.9	-4.1	3.2
Eye problems/disorders: None of the above	2.5	2.8	5.4	2.2	1.6	0.0	1.3	-1.6	2.3
Mouth/teeth dental problems: Loose teeth	1.5	1.7	2.7	-1.6	-1.2	-1.3	-1.2	1.4	-1.1
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.4	0.7	-0.3	1.1	-0.8	0.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.5	1.6	0.7	0.6	1.3	-1.2	0.9
Neck or shoulder pain in last month	1.8	2.5	5.0	-1.9	-1.3	-2.2	-1.0	1.4	-1.3
Medication: Blood pressure	0.1	0.2	0.5	-0.3	-0.7	0.3	0.4	0.3	-0.3
Angina (self-reported)	3.9	5.1	11.0	-3.3	-1.9	-0.6	-2.4	2.6	-1.7
Migraine (self-reported)	0.5	0.7	1.9	-0.5	-1.4	-1.1	-0.2	0.6	-0.5
Medication: Ibuprofen	0.4	0.5	1.5	0.1	0.7	0.0	-0.9	0.4	1.2
Medication: Allopurinol	0.5	0.7	3.0	-0.6	-0.1	0.6	-0.5	0.2	-1.7
Medication: Omeprazole	0.1	0.2	0.7	-0.1	-0.2	0.4	0.8	-0.0	0.1
Medication: Seretide 50 evohaler	1.3	1.5	3.0	-1.4	-1.7	-1.7	-0.3	0.8	-0.6
Mean time to correctly identify matches	0.8	1.5	3.7	-1.5	-0.5	-0.3	-1.9	1.3	-0.9
Heart disease (mother)	3.2	3.9	6.6	-2.1	-1.8	-0.9	-2.3	2.6	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	1.1	1.0	0.8	0.1	-0.3	1.3
Whole body fat mass	0.4	1.5	3.6	-1.1	-1.5	-1.9	-0.9	0.9	0.3
Leg fat mass (right)	0.1	0.4	1.5	-0.2	-0.2	-1.0	0.1	0.2	1.2
Arm predicted mass (right)	0.2	0.9	3.1	0.4	-1.2	-1.8	0.3	-0.1	0.7
Pulse rate, automated reading	1.0	3.2	5.8	1.2	2.2	2.4	1.9	-1.0	1.7
Alcohol intake frequency.	0.5	1.1	2.8	0.9	1.7	1.4	-0.2	-0.9	-0.1
Comparative height size at age 10	1.1	6.1	10.1	-2.9	-2.7	-3.2	-1.8	2.7	-0.7
Number of full sisters	0.2	0.3	1.3	0.5	-0.1	0.2	-0.2	-0.3	-1.1
Suffer from ‘nerves’	4.2	6.5	12.6	-2.4	-1.8	-1.7	-3.0	2.5	-3.6
Overall health rating	0.6	1.4	3.7	-1.2	-0.6	0.8	-1.3	1.9	-0.5
Chest pain or discomfort	0.2	0.3	0.8	-0.9	-0.5	0.3	0.3	0.6	-0.5
Had major operations	0.6	0.7	1.7	0.6	1.0	1.3	0.6	-0.6	0.2
Age at last live birth	0.3	0.5	1.2	-0.4	-1.1	-0.3	-0.7	0.4	-0.9
Family relationship satisfaction	0.5	0.6	1.5	1.2	1.0	0.9	-0.1	-0.4	0.5
Leg pain on walking	0.5	0.7	2.1	-0.4	0.0	0.3	-1.4	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	2.8	-1.7	-1.4	-1.1	-1.3	1.5	-1.4
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.2	1.2	2.2	2.5	0.7	-1.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	1.1	0.9	0.4	0.4	-1.2	-0.0
Medication: Aspirin	0.3	0.4	1.9	-0.6	0.3	1.4	0.3	-0.0	-0.5
Supplements: Vitamin C	1.7	2.1	4.6	-1.7	-2.1	-0.9	0.0	0.8	-1.8
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	0.5	0.3	-0.3	0.1	0.3
Hypertension (Self-reported)	0.3	0.9	1.7	-1.2	-1.3	0.0	-0.5	0.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.2	7.1	-2.1	-1.6	-0.7	-0.9	2.0	-2.7
Illnesses of father: Heart disease	0.2	0.3	0.7	-0.4	0.4	0.1	-0.8	0.8	0.6
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.4	0.4	-0.1	0.0	-0.1	-0.3
Smoking status: Previous	1.4	2.1	4.4	-1.4	-2.0	-2.1	-0.7	1.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.7	-0.8	-1.6	-2.4	-0.7	1.2	0.5
Whole body fat-free mass	0.3	1.5	4.5	-0.5	-1.9	-2.1	-0.5	0.6	0.3
Leg fat-free mass (right)	0.4	2.3	4.7	-1.2	-2.2	-2.1	-1.3	1.1	-0.4
Arm fat percentage (left)	0.2	0.7	1.5	-0.7	-1.1	-1.2	-0.8	0.3	0.0
Average weekly red wine intake	4.2	6.1	8.8	3.0	2.3	1.5	2.4	-2.9	2.4
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.9	-1.2	-1.4	-1.3	-0.8	0.7	-2.0
Mood swings	3.1	5.6	10.1	-2.4	-2.4	-3.2	-2.4	2.1	-1.1
Loneliness, isolation	1.0	1.4	3.4	-1.2	-1.0	-0.8	-1.2	0.8	-1.9
Long-standing illness, disability or infirmity	2.7	4.1	8.8	-3.0	-1.2	-0.7	-2.2	2.8	-1.1
Ever had bowel cancer screening	0.2	0.3	0.7	-0.5	-0.8	-0.4	0.0	0.7	0.2
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.7	-0.1	0.1	0.2	0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	5.5	2.4	1.1	1.0	2.1	-2.2	0.6
Friendships satisfaction	0.4	0.5	1.0	-0.0	1.0	0.8	-0.9	0.5	0.4
Qualifications: nursing, teaching	4.4	6.8	11.0	2.3	2.9	1.3	3.0	-2.5	3.3
Commuting to job workplace: Walk	1.3	1.4	2.9	-1.4	-1.7	-1.4	-0.5	0.6	-0.9
Eye problems/disorders: Cataract	1.8	2.1	3.7	-1.9	-1.0	-0.1	-1.3	1.6	-1.9
Mouth/teeth dental problems: Mouth ulcers	4.1	6.5	9.1	-2.5	-2.7	-2.8	-3.0	2.6	-1.3
Medication for cholesterol	0.1	0.1	0.2	-0.1	-0.4	0.1	-0.2	0.4	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.6	-1.5	-0.4	0.1	0.1	0.9	-1.6
Back pain experienced in last month	0.2	0.3	1.2	-0.4	-0.2	-0.3	-0.1	0.6	1.1
Mineral and other dietary supplements	0.1	0.1	0.4	0.4	-0.2	0.0	-0.3	-0.1	-0.6
Breast cancer (self-reported)	0.4	0.5	2.6	-0.3	-0.3	-0.5	0.1	0.3	-1.6
Asthma (self-reported)	0.0	0.1	0.3	-0.1	-0.3	-0.5	0.3	0.1	0.0
Osteoporosis (self-reported)	1.0	1.2	1.8	1.1	1.1	1.2	1.4	-0.6	1.2
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.1	-0.7	-0.0	0.6	-0.6	0.1
Medication: Aspirin	0.4	0.5	1.7	-1.0	0.2	1.3	0.2	0.1	-0.4
Medication: Gliclazide	0.1	0.1	0.4	-0.1	0.0	-0.1	0.0	0.4	-0.6
Illnesses of father: None of the above (group 1)	0.8	1.0	2.3	1.0	-0.3	-0.4	1.2	-1.5	-0.9
Smoking status: Current	0.5	0.7	1.5	-0.8	-0.3	0.6	-0.4	1.2	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.3	0.0	-0.2	-0.1	-0.6	-0.2	0.2
Whole body water mass	0.3	1.5	4.6	-0.4	-1.8	-2.1	-0.5	0.6	0.4
Leg predicted mass (right)	0.5	2.5	4.9	-1.3	-2.2	-2.2	-1.4	1.2	-0.4
Arm fat mass (left)	0.2	0.7	2.2	-0.6	-1.2	-1.5	-0.5	0.3	0.3
Number of self-reported non-cancer illnesses	1.3	2.3	5.3	-2.3	-0.8	-0.4	-1.1	1.6	-2.0
Average weekly champagne plus white wine intake	2.0	2.7	5.3	1.9	1.3	1.6	1.8	-2.3	0.1
Miserableness	0.9	1.6	3.1	-0.8	-1.8	-0.3	-1.2	1.0	-1.7
Guilty feelings	2.4	3.6	5.5	-2.2	-2.1	-1.9	-1.7	2.4	-0.6
Wears glasses or contact lenses	0.5	0.5	1.8	0.6	0.6	1.4	0.2	-0.7	-0.3
Ever taken oral contraceptive pill	0.2	0.3	0.8	-0.9	-0.2	-0.7	-0.0	0.4	-0.3
Hearing aid user	0.3	0.4	1.2	-0.3	-0.3	0.2	-1.1	0.6	0.7
Mother’s age at death	1.4	1.8	4.2	1.6	1.0	1.1	1.2	-2.1	0.5
Financial situation satisfaction	0.1	0.1	0.5	0.7	0.1	0.1	0.1	-0.1	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.0	-0.3	-0.6	0.8	-0.2	-0.1
Commuting to job workplace: Public transport	0.4	0.4	2.1	0.4	-0.4	-1.4	-0.1	-0.3	-0.3
Eye problems/disorders: Glaucoma	1.9	2.2	4.0	1.5	1.4	2.0	1.5	-1.6	0.3
Medication: Blood pressure	0.1	0.2	0.7	-0.0	-0.2	0.6	-0.3	-0.4	-0.8
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.6	-1.6	-1.9	-1.4	-1.2	1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.4	0.5	0.2	0.8	-0.1	0.9
High cholesterol (Self-reported)	0.2	0.3	0.5	0.3	0.6	0.6	0.7	-0.4	0.7
Medication: Bendroflumethiazide	0.5	0.7	1.5	0.9	0.7	1.0	0.4	-1.2	-0.4
Medication: Paracetamol	0.2	0.2	0.7	-0.6	-0.4	-0.2	-0.8	0.3	-0.2
Medication: Lisinopril	0.1	0.2	0.5	-0.2	-0.5	-0.3	0.4	-0.0	-0.7
Medication: Atorvastatin	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.1
Illnesses of father: High blood pressure	1.9	2.4	3.6	-1.9	-1.6	-1.6	-1.4	1.8	-0.3
Alcohol drinker status: Never	1.4	1.6	4.5	-0.9	-1.1	-2.1	-1.2	1.0	-0.7
Ever smoked	1.0	1.7	3.2	-1.6	-1.2	-1.2	-0.7	1.8	1.0
Basal metabolic rate	0.3	1.5	4.6	-0.6	-1.8	-2.1	-0.7	0.7	0.3
Leg fat percentage (left)	0.2	0.5	2.6	0.3	0.4	-0.4	0.5	-0.3	1.6
Arm fat-free mass (left)	0.2	0.9	3.3	-0.1	-1.3	-1.8	-0.1	0.3	0.7
Number of operations (self-reported)	0.1	0.1	0.5	-0.7	0.5	-0.2	0.1	0.3	-0.1
Average weekly beer plus cider intake	1.5	2.2	3.3	-1.4	-1.8	-1.7	-1.1	1.6	-1.0
Irritability	1.0	1.7	2.9	-1.5	-0.7	-1.1	-1.7	1.7	-0.5
Risk taking	1.0	1.4	3.4	1.1	1.3	0.1	1.9	-1.3	0.6
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.9	-0.9	-1.9	-2.2	-0.5	0.8	0.1
Fractured/broken bones in last 5 years	0.6	0.8	3.7	-0.3	0.9	1.9	-0.2	0.6	-0.1
Age started oral contraceptive pill	0.2	0.2	0.6	-0.4	0.4	0.2	-0.8	0.0	-0.6
Diastolic blood pressure, automated reading	0.1	0.5	0.9	-0.9	-0.2	0.9	0.0	0.6	-0.8
Ever depressed for a whole week	0.9	1.1	4.4	0.6	1.2	2.1	-0.5	-0.1	-0.1
Unable to work because of sickness or disability	0.5	0.6	1.8	-1.0	-0.8	-0.3	0.5	0.4	-1.3
Commuting to job workplace: Cycle	4.7	5.7	9.6	3.1	2.1	1.5	2.4	-2.7	2.2
Myopia	0.8	1.1	3.2	1.8	0.7	0.3	0.9	-1.4	0.4
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.8	1.9	2.2	0.6	0.8	-1.3	1.9
Cholesterol lowering medication	0.1	0.1	0.3	0.1	0.6	0.3	-0.2	-0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-0.9	-0.5	-0.2	0.1	0.5	-0.9
Pain experienced in last month	1.5	2.5	4.5	2.0	1.7	2.1	1.2	-1.4	0.4
Supplements: Calcium	0.9	1.0	2.2	0.3	1.1	1.4	1.5	-0.7	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	-0.5	0.2	0.5	-0.3	0.2	-1.4
Heart attack/myocardial infarction (self-reported)	2.7	3.5	5.4	-2.3	-1.7	-0.9	-1.8	1.9	-2.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.7	0.8	1.3	1.3	-0.1	-0.6	0.8
Heart disease (siblings)	0.1	0.1	0.3	-0.1	0.5	0.2	0.2	-0.0	0.6
Alcohol drinker status: Previous	0.3	0.4	1.3	0.0	-0.5	-0.7	0.1	0.5	1.1
Pack years of smoking	0.2	0.3	0.9	1.0	0.1	-0.2	0.0	-0.4	1.0
Impedance of whole body	0.7	3.4	5.9	-2.1	-1.8	-2.0	-1.6	2.4	0.1
Leg fat mass (left)	0.1	0.4	1.3	-0.2	-0.3	-1.0	-0.1	0.2	1.1
Arm predicted mass (left)	0.2	1.0	3.6	-0.0	-1.3	-1.9	-0.2	0.3	0.9