TWAS hub - GPR19

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0673	0.0326	0.00190	0.039	0.036	0.038	NA	0.032	3.1e-05	5.4e-05	4.1e-05	NA	0.00015
2	TCGA	Lung Adenocarcinoma	0.0615	0.0252	0.00097	0.003	0.014	-0.002	NA	0.000	1.2e-01	8.6e-03	9.8e-01	NA	0.31000
3	TCGA	Thyroid Carcinoma	0.0610	0.0270	0.00270	0.011	0.019	0.011	NA	0.019	2.6e-02	4.8e-03	2.6e-02	NA	0.00520

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Type 2 Diabetes (T2D) (2012)	8.0	9.2	11.4	2.6	3.1	3.4
Pain all over the body in last month	6.4	6.9	11.2	1.7	2.5	3.4
Illnesses of siblings: Diabetes	6.1	7.6	12.1	2.3	2.3	3.5
Ulcerative Colitis (UC)	5.3	9.9	12.4	3.5	2.7	3.1
Ulcerative Colitis	5.1	7.4	9.7	2.5	2.5	3.1
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	9.4	-3.1	-2.3	-1.7
Trunk fat-free mass	3.4	19.7	21.9	-4.6	-4.7	-4.0
Happiness	3.4	4.2	6.9	2.2	2.6	0.9
Trunk predicted mass	3.4	19.3	21.0	-4.6	-4.6	-4.0
Ever had prostate specific antigen (PSA) test	3.4	4.0	4.4	-2.1	-2.1	-1.8
Cholesterol lowering medication	3.4	5.1	8.1	2.8	1.6	2.2
Emphysema/chronic bronchitis	3.3	3.7	5.4	2.3	1.7	1.7
Migraine (self-reported)	3.3	4.1	5.3	-2.1	-1.6	-2.3
Relative age of first facial hair	3.2	6.7	8.8	-1.8	-2.8	-3.0
Shortness of breath walking on level ground	3.2	3.8	6.3	2.0	1.2	2.5
Medication: Ramipril	3.1	4.0	5.5	-1.5	-2.1	-2.4
Ever highly irritable/argumentative for 2 days	3.1	3.7	4.2	1.7	2.0	2.0
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	6.8	-2.5	-1.3	-2.6
Pain type(s) experienced in last month: Hip pain	3.1	3.9	5.1	2.3	1.7	1.9
Ever used hormone-replacement therapy (HRT)	2.9	3.7	6.1	2.5	1.5	1.6
Ever had hysterectomy (womb removed)	2.9	3.2	6.7	1.4	1.0	2.6
Whole body fat-free mass	2.9	16.3	20.0	-4.2	-4.5	-3.4
Sitting height	2.8	20.1	21.8	-4.1	-4.7	-4.7
Whole body water mass	2.8	16.2	20.3	-4.2	-4.5	-3.3
Arm predicted mass (left)	2.8	14.4	16.4	-4.0	-4.1	-3.3
Birth weight of first child	2.7	4.9	7.6	-2.5	-2.8	-1.0
Hearing difficulty/problems: Yes	2.6	3.9	4.3	-2.1	-2.0	-1.9
Exposure to tobacco smoke at home	2.6	2.9	5.4	-2.3	-1.6	-1.0
Headache pain in last month	2.6	4.6	5.7	-2.4	-1.7	-2.3
Qualifications: nursing, teaching	2.6	4.0	6.4	-1.9	-2.5	-1.5
Smoking status: Current	2.6	4.0	4.9	1.6	2.2	2.2
Arm fat-free mass (left)	2.6	13.2	15.1	-3.9	-3.9	-3.1
Hayfever/allergic rhinitis (self-reported)	2.5	3.4	5.4	2.3	1.6	1.4
Qualifications: A levels/AS levels or equivalent	2.5	5.6	6.1	-2.2	-2.5	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	10.4	-3.2	-2.5	-2.5
Arm fat-free mass (right)	2.4	12.5	15.1	-3.7	-3.9	-3.0
Arm predicted mass (right)	2.4	12.5	14.8	-3.7	-3.8	-3.0
Irritable Bowel Disease (IBD)	2.3	5.4	7.1	2.3	2.0	2.7
Severe depression (siblings)	2.3	2.6	3.7	-1.9	-1.1	-1.7
Hearing difficulty/problems with background noise	2.3	3.7	5.7	-2.0	-2.4	-1.2
Chronic bronchitis/emphysema (mother)	2.3	2.7	4.3	0.5	2.1	1.8
Forced vital capacity (FVC), Best measure	2.3	8.5	10.0	-3.2	-2.9	-2.7
Basal metabolic rate	2.3	12.9	16.4	-3.8	-4.0	-2.8
Current tobacco smoking	2.2	3.6	4.7	1.4	2.2	2.1
Pulse rate	2.2	3.8	6.5	-1.3	-2.5	-1.8
Standing height	2.2	21.8	27.6	-4.6	-5.2	-4.1
Medication: Seretide 50 evohaler	2.2	2.5	4.0	1.4	1.3	2.0
Forced vital capacity (FVC)	2.1	8.2	10.6	-3.3	-2.8	-2.5
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	10.9	-3.3	-2.4	-2.1
Noisy workplace	2.1	2.6	3.1	1.8	1.2	1.8
Leg fat-free mass (left)	2.0	10.8	15.3	-3.4	-3.9	-2.3
Leg predicted mass (left)	2.0	10.6	14.9	-3.4	-3.9	-2.3
Leg fat-free mass (right)	2.0	10.7	15.1	-3.4	-3.9	-2.4
Leg predicted mass (right)	2.0	10.5	14.9	-3.3	-3.9	-2.4
High cholesterol (Self-reported)	2.0	3.6	7.0	2.6	1.6	1.1
High blood pressure (mother)	1.9	2.7	3.6	-1.5	-1.9	-1.5
Had other major operations	1.9	2.3	2.5	1.5	1.6	1.4
Peak expiratory flow (PEF)	1.9	4.3	9.2	-3.0	-1.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.5	1.4	2.1	0.7
Respiratory disease	1.8	3.9	9.0	3.0	1.2	1.1
Hand grip strength (right)	1.8	4.9	7.3	-1.8	-2.7	-2.0
Medication: Blood pressure	1.8	3.3	6.7	-0.0	-2.6	-1.7
Medication: Paracetamol	1.8	2.8	5.6	1.3	2.4	1.0
Number of operations (self-reported)	1.8	2.7	4.1	1.7	1.0	2.0
Diabetes (mother)	1.7	2.2	4.9	0.5	1.1	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	3.2	0.5	1.8	1.8
Long-standing illness, disability or infirmity	1.7	2.6	3.1	1.4	1.8	1.7
Mean Putamen Volume	1.6	1.9	3.9	0.7	1.1	2.0
Height	1.6	30.4	40.5	-5.6	-6.4	-4.4
Prospective memory result	1.6	2.0	4.7	1.1	0.2	2.2
Family relationship satisfaction	1.6	2.0	3.0	1.1	1.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	4.7	-1.9	-2.2	-1.3
Supplements: Calcium	1.6	1.7	4.0	-2.0	-0.3	-1.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	5.3	-2.3	-1.9	-2.1
Fluid intelligence score	1.5	3.2	6.6	-2.6	-0.5	-1.6
Illnesses of mother	1.5	1.8	4.2	-2.0	-0.5	-1.0
Alzheimer’s Disease (in father)	1.4	1.5	2.0	1.3	1.4	0.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.2	-1.5	-1.5	-0.6
Had menopause	1.4	1.7	2.4	1.2	1.2	1.5
Qualifications: None of the above	1.4	3.0	3.6	1.8	1.4	1.9
Medication: Paracetamol	1.4	2.2	4.8	1.1	2.2	0.8
Diabetes (father)	1.3	1.6	2.2	1.5	0.9	1.3
Medication for cholesterol	1.3	2.0	5.0	-2.2	-0.7	-0.7
Commuting to job workplace: Cycle	1.3	1.5	2.8	-1.7	-1.0	-0.8
Smoking Status	1.2	2.9	4.2	0.8	1.9	2.1
Medication: Metformin	1.2	1.6	3.5	1.9	0.7	1.0
Impedance of arm (right)	1.2	5.4	5.9	2.4	2.3	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.2	1.0	1.5	1.1
Ever depressed for a whole week	1.2	1.5	2.4	-0.4	1.6	1.3
Alcohol drinker status: Previous	1.2	1.3	2.0	1.4	-0.4	1.3
Hypothyroidism (self reported)	1.1	2.4	3.2	1.1	1.8	1.7
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.3	1.8	0.5	1.5
Falls in the last year	1.1	1.4	3.3	0.6	1.8	0.8
Impedance of arm (left)	1.1	5.1	5.9	2.4	1.9	2.4
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	1.8	0.9	1.2	1.3
Systolic Blood Pressure	1.0	5.2	7.7	1.7	-2.2	-2.8
Alcohol usually taken with meals	1.0	1.6	2.8	-1.7	-1.5	-0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	1.8	0.7	1.3	1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.1	-1.0	-0.7	-1.4
Medication: Ibuprofen	1.0	1.2	1.9	0.0	1.3	1.4
Ever taken oral contraceptive pill	1.0	1.1	2.1	0.9	0.6	1.4
Medication: Bendroflumethiazide	1.0	1.5	2.1	1.4	-0.8	-1.3
Impedance of whole body	1.0	5.2	5.7	2.4	2.3	2.1
Schizophrenia (2018)	0.9	1.9	2.9	1.7	0.4	1.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.7	-1.9	-0.8	-1.4
Fasting Glucose	0.9	1.1	1.7	0.7	-1.1	-1.3
Serious illness, injury or assault to yourself	0.9	1.1	1.9	0.3	1.4	1.1
Age at first live birth	0.9	1.6	2.7	-1.4	-0.5	-1.6
Medication for pain relief, constipation, heartburn	0.9	1.5	2.9	-0.8	-1.7	-0.9
Back pain experienced in last month	0.9	1.3	1.9	0.3	1.4	1.4
Number of self-reported non-cancer illnesses	0.9	1.6	2.3	1.3	1.5	0.9
Irritability	0.9	1.5	2.4	1.5	1.0	1.0
Pain experienced in last month	0.9	1.5	2.7	0.5	-1.3	-1.6
Blood White Count	0.8	6.3	11.7	-0.7	2.6	3.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.5	1.6	0.3	0.5
High blood pressure	0.8	2.2	2.5	1.5	-1.6	-1.3
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.4	-0.2	1.2	1.2
Allergy	0.8	1.9	3.5	-1.9	-0.6	-1.3
Diabetes (self-reported)	0.8	1.2	2.7	1.7	0.2	1.0
Father’s age at death	0.8	1.1	2.9	-1.7	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.3	-1.1	0.5	-1.1
Asthma	0.8	1.5	3.5	1.9	0.8	0.6
Comparative height size at age 10	0.8	4.2	6.1	-2.1	-2.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	-1.4	-0.8	0.2
Wears glasses or contact lenses	0.8	0.9	1.8	-0.3	-1.3	-0.9
Hearing aid user	0.8	0.9	1.2	1.1	0.6	1.1
Reaction Time	0.7	1.3	2.7	0.5	1.0	1.6
Primary Biliary Cirrhosis	0.7	1.0	2.7	0.4	-0.0	1.6
Cardiovascular Disease	0.7	2.2	6.0	2.5	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	-0.5	-1.4	-0.7
Qualifications: CSEs or equivalent	0.7	1.0	2.7	1.7	-0.2	0.4
Impedance of leg (left)	0.7	3.5	6.2	1.6	2.5	1.3
Weight	0.7	3.3	4.8	-2.2	-2.1	-0.8
Time employed in main current job	0.7	0.8	2.0	0.4	-1.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.7	0.9	1.0	1.3
Medication: Lansoprazole	0.7	0.8	2.0	0.1	1.4	0.6
Pulse wave Arterial Stiffness index	0.7	0.8	1.2	-1.0	-1.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.7	0.5	0.5	1.7
High blood pressure (siblings)	0.7	1.1	2.1	0.5	-1.4	1.0
Number of children fathered	0.7	0.7	2.1	1.5	-0.3	-0.1
Medication: Omeprazole	0.7	0.8	1.1	0.6	1.0	1.0
Mean time to correctly identify matches	0.7	1.4	2.2	0.8	1.1	1.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.1	0.7	-1.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.2	-0.0	1.5	0.6
Asthma (self-reported)	0.7	1.4	3.0	1.7	0.9	0.5
Commuting to job workplace: Public transport	0.7	0.9	2.4	-1.6	0.3	0.2
Medication: Blood pressure	0.7	1.4	4.1	2.0	0.0	0.1
Medication: Atorvastatin	0.7	0.8	2.0	1.4	0.5	0.4
Leg fat percentage (left)	0.7	2.4	3.6	0.8	1.7	1.9
Bipolar Disorder or Schizophrenia	0.6	1.4	2.1	1.5	0.2	1.4
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	1.5	0.0	0.5
Schizophrenia (2014)	0.6	1.3	2.2	1.3	0.2	1.5
Blood Eosinophil Count	0.6	4.7	6.9	1.1	2.6	2.5
Lung FVC	0.6	3.2	4.8	-1.9	-1.0	-2.2
Impedance of leg (right)	0.6	3.0	5.0	1.5	2.2	1.3
Maternal smoking around birth	0.6	0.9	1.2	1.1	0.8	0.9
Stomach or abdominal pain in last month	0.6	0.7	1.1	-1.0	-0.7	-0.8
Medication: Atenolol	0.6	0.7	1.8	1.3	0.4	0.5
Body fat percentage	0.6	2.2	4.3	0.9	1.2	2.1
Leg fat percentage (right)	0.6	2.2	3.4	0.7	1.6	1.8
Overall health rating	0.6	1.2	2.5	0.8	0.7	1.6
Hypertension (Self-reported)	0.6	1.6	2.6	1.6	-1.3	-0.8
Arm fat percentage (left)	0.6	2.5	5.1	1.1	1.1	2.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-1.4	-0.4	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.0	1.4	0.5	0.9
Eye problems/disorders: Cataract	0.6	0.7	1.5	-0.6	-0.5	-1.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.4	-1.3	1.5	1.1
HbA1C	0.5	0.5	1.3	-0.2	-1.1	-0.5
Blood Red Count	0.5	4.8	5.2	-2.3	-2.0	-2.3
Hand grip strength (left)	0.5	1.4	1.8	-1.3	-1.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	-1.2	0.8	0.0
Medication for hormone replacement therapy	0.5	0.6	1.5	-1.2	0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	0.4	1.3	0.2
Illnesses of siblings	0.5	0.7	1.8	-0.5	0.3	-1.3
Arm fat percentage (right)	0.5	1.9	3.4	1.0	1.1	1.8
Hair/balding pattern: Pattern 3	0.5	0.7	2.2	-0.1	-0.2	-1.5
Lung cancer (father)	0.5	0.6	1.5	1.2	0.5	0.3
Glaucoma (self-reported)	0.5	0.6	1.0	-1.0	-0.9	-0.4
Medication: Amlodipine	0.5	0.7	0.8	0.9	-0.8	-0.8
Wheeze or whistling in the chest in last year	0.5	0.8	1.8	1.3	0.7	0.4
Pulse wave peak to peak time	0.5	0.6	1.1	0.7	1.0	0.5
Neck or shoulder pain in last month	0.5	0.8	2.0	0.6	0.1	1.4
Alcohol intake frequency.	0.5	1.2	2.9	1.7	0.2	0.8
Chest pain or discomfort	0.5	0.8	1.4	0.9	1.2	0.4
Leg pain on walking	0.5	0.7	1.4	-1.2	0.2	-0.7
Medication: Aspirin	0.5	0.7	1.4	0.2	-0.7	-1.2
Breast cancer (self-reported)	0.5	0.6	0.9	-1.0	0.6	-0.6
Medication: Aspirin	0.5	0.7	1.1	0.1	-0.9	-1.0
Alcohol drinker status: Never	0.5	0.6	1.0	-0.4	-1.0	-0.8
Lung FEV1/FVC ratio	0.4	2.0	6.0	-2.5	0.1	0.2
Number of treatments/medications taken	0.4	0.7	1.7	1.3	0.7	0.1
Sensitivity / hurt feelings	0.4	0.6	1.8	0.1	1.4	0.2
Systolic blood pressure, automated reading	0.4	1.2	1.7	1.3	-0.6	-1.2
Pack years adult smoking proportion	0.4	0.6	1.1	0.7	0.6	1.0
Trunk fat percentage	0.4	1.7	3.7	0.8	0.8	1.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	1.0	0.1	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	0.5	0.5	0.9
Number of incorrect matches in round	0.4	0.6	1.5	-0.7	-1.2	-0.1
Past tobacco smoking	0.4	0.8	1.4	1.2	0.5	-0.8
Worrier / anxious feelings	0.4	0.7	1.8	1.3	-0.2	0.5
Number of live births	0.4	0.6	1.4	-0.6	-1.2	0.2
Length of working week for main job	0.4	0.4	0.8	-0.9	-0.2	-0.7
Tense / ‘highly strung’	0.4	0.6	0.9	0.9	0.2	0.9
Loud music exposure frequency	0.4	0.4	1.1	-0.2	-1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.3	0.6	1.2	0.8
Birth weight	0.4	0.8	2.3	-0.3	-1.5	-0.1
Number of full sisters	0.4	0.5	0.7	-0.8	-0.8	0.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	0.2	-1.1	-0.5
Supplements: Vitamin C	0.4	0.5	0.9	-0.9	0.1	-0.8
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.1	-1.1	-0.6
Mood swings	0.4	0.6	0.8	0.9	0.6	0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.1	-1.1	0.5	0.2
Medication: Lisinopril	0.4	0.5	0.7	0.6	0.8	0.6
Depressed Affect (Nagel 2018)	0.3	0.5	0.8	0.8	0.9	0.4
Depression (Nagel 2018)	0.3	0.5	0.7	-0.8	-0.5	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	-0.0	0.9	0.4
Major Depression (MDD)	0.3	0.3	0.8	-0.9	-0.5	0.0
Ovarian Cancer	0.3	0.5	0.9	-0.6	0.4	-1.0
BMI	0.3	1.8	4.2	0.7	0.9	2.0
Chronotype (morning person)	0.3	0.6	1.0	-1.0	-0.9	-0.0
Townsend deprivation index at recruitment	0.3	0.5	0.7	0.1	0.8	0.9
Taking other prescription medications	0.3	0.5	0.6	0.6	0.7	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-1.0	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.6	-0.3	0.0	-1.3
Heart attack	0.3	0.4	0.8	-0.5	0.1	-0.9
Breastfed as a baby	0.3	0.4	0.6	-0.7	-0.8	-0.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	0.8	1.2	0.5
Blood clot in the leg (DVT)	0.3	0.4	0.6	-0.8	0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.4	1.1	0.5
Worry too long after embarrassment	0.3	0.5	1.4	-1.2	0.1	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.5	0.7	0.5
Qualifications: College or University degree	0.3	0.9	1.7	-1.3	-0.8	-0.5
Medication: Allopurinol	0.3	0.4	0.7	-0.6	-0.0	0.9
Ever had bowel cancer screening	0.3	0.4	0.7	-0.5	0.9	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.2	0.7	0.7
Mother’s age at death	0.3	0.4	1.1	-0.4	0.2	1.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	0.6	0.9	0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	1.0	0.3	0.2
Ever smoked	0.3	0.6	1.2	-1.1	-0.5	0.6
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.7	0.8	0.2
Myopia	0.3	0.5	0.8	0.9	-0.4	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.4	0.2	-1.0
Pack years of smoking	0.3	0.5	0.9	0.5	0.5	1.0
Neuroticism (Nagel 2018)	0.2	0.4	0.9	0.3	0.9	0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	-0.0	0.3
Crohns Disease (2017)	0.2	0.4	0.8	-0.2	0.5	0.9
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.7	-0.0	0.5
HDL Cholesterol	0.2	0.3	0.6	-0.4	0.4	-0.7
Lupus	0.2	0.3	0.5	0.4	0.7	-0.5
Neuroticism (2016)	0.2	0.3	0.5	0.5	0.0	0.7
Triglycerides	0.2	0.3	0.7	0.2	0.9	0.4
Blood Platelet Count	0.2	2.1	4.6	-2.1	0.2	-1.3
Heel T-Score	0.2	1.8	3.2	1.2	1.8	0.9
Waist Hip Ratio (WHR)	0.2	0.9	2.3	-1.5	-0.6	-0.0
Allergy or Eczema	0.2	0.6	1.0	0.6	0.6	1.0
Neuroticism	0.2	0.6	1.0	-0.5	-0.6	-1.0
Angina	0.2	0.2	0.5	-0.4	-0.2	-0.7
Supplements: Zinc	0.2	0.2	0.4	-0.4	0.4	0.6
Relative age voice broke	0.2	0.3	0.6	0.4	-0.8	-0.5
Age when periods started (menarche)	0.2	0.4	0.9	-0.1	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	0.2	-0.4	-1.0
Multivitamins +/- minerals	0.2	0.3	0.7	0.8	0.1	-0.3
Medication: Levothyroxine sodium	0.2	0.4	0.6	-0.7	0.8	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.4	-0.6	-0.6	-0.2
Mouth/teeth dental problems	0.2	0.3	0.7	0.9	0.5	0.0
Hip circumference	0.2	1.0	1.7	-1.3	-1.1	-0.2
Comparative body size at age 10	0.2	0.5	1.1	0.1	-0.6	1.0
Health satisfaction	0.2	0.3	0.6	0.2	-0.5	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.4	0.5	0.3
Angina (self-reported)	0.2	0.2	0.5	-0.4	-0.1	-0.7
Heart disease (mother)	0.2	0.3	0.7	0.8	0.0	0.3
Pulse rate, automated reading	0.2	0.6	1.0	-1.0	0.5	0.7
Suffer from ‘nerves’	0.2	0.3	0.9	-0.3	0.1	1.0
Had major operations	0.2	0.2	0.3	-0.5	-0.5	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.6	0.7	0.1
Knee pain experienced in last month	0.2	0.3	0.4	-0.6	0.5	0.6
Smoking status: Previous	0.2	0.3	0.7	-0.8	-0.3	0.4
Average weekly red wine intake	0.2	0.3	0.6	-0.8	-0.6	0.1
Loneliness, isolation	0.2	0.3	0.5	0.5	0.7	-0.3
Friendships satisfaction	0.2	0.3	0.5	-0.4	0.5	0.7
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.8	-0.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.2	1.0	-0.4
Miserableness	0.2	0.3	0.5	-0.7	-0.5	-0.2
Financial situation satisfaction	0.2	0.2	0.4	-0.5	0.6	0.2
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.7	0.0	0.1
Average weekly beer plus cider intake	0.2	0.4	0.6	0.8	0.4	-0.5
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.8	0.0	0.1
Age started oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.0	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.5	0.3	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.6	0.3	-0.7
Heart disease (siblings)	0.2	0.3	0.5	-0.7	-0.6	0.1
Worry (Nagel 2018)	0.1	0.1	0.2	0.3	0.2	0.5
Age at First Birth	0.1	0.1	0.3	-0.0	0.5	0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.4	-0.0	-0.6	0.2
Crohns Disease (2012)	0.1	0.2	0.5	-0.7	0.0	0.2
LDL Cholesterol	0.1	0.1	0.3	-0.6	-0.0	-0.3
Hair Pigment	0.1	2.1	5.4	-2.3	-0.8	-0.4
Tanning	0.1	1.2	2.3	1.5	0.3	1.1
Average weekly spirits intake	0.1	0.1	0.3	-0.2	-0.5	0.1
Vitamin and mineral supplements	0.1	0.1	0.2	-0.3	-0.3	0.4
Fed-up feelings	0.1	0.1	0.3	-0.1	-0.3	-0.5
Supplements: Glucosamine	0.1	0.1	0.3	0.5	-0.0	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.3	0.3	0.2
Body mass index (BMI)	0.1	0.3	0.7	-0.2	0.2	0.9
Trunk fat mass	0.1	0.3	0.6	-0.4	-0.4	0.8
Waist circumference	0.1	0.5	1.2	-1.1	-0.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.2	-0.3	0.4
Neuroticism score	0.1	0.3	0.3	0.5	0.6	0.4
Medication: Cholesterol lowering	0.1	0.2	0.4	0.3	0.6	-0.1
Depression (self-reported)	0.1	0.1	0.2	-0.2	0.4	0.5
Arm fat mass (right)	0.1	0.3	0.4	-0.7	-0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.2	-0.5	-0.1
Gout (self-reported)	0.1	0.1	0.2	-0.4	-0.1	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.1	0.1	-0.7
Whole body fat mass	0.1	0.4	0.9	-0.4	-0.2	0.9
Leg fat mass (right)	0.1	0.3	0.6	-0.7	-0.1	0.6
Age at last live birth	0.1	0.2	0.4	-0.3	0.1	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.3	0.6	-0.0	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.3	0.5	0.3
Medication: Gliclazide	0.1	0.1	0.2	0.1	0.0	0.4
Arm fat mass (left)	0.1	0.4	0.5	-0.7	-0.6	0.6
Guilty feelings	0.1	0.1	0.3	0.5	0.2	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	-0.4	0.2
Risk taking	0.1	0.2	0.4	0.0	0.6	0.4
Leg fat mass (left)	0.1	0.3	0.6	-0.6	-0.0	0.8
Bipolar Disorder (2018)	0.0	0.0	0.1	0.3	-0.1	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.1	-0.0	-0.2
Rheumatoid Arthritis	0.0	0.0	0.1	-0.1	-0.3	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	-0.1	-0.1	-0.2
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.0	-0.1
Average weekly fortified wine intake	0.0	0.0	0.0	-0.0	0.2	0.2
Nervous feelings	0.0	0.0	0.1	-0.0	0.0	0.2
Medication: Simvastatin	0.0	0.0	0.1	-0.0	0.3	-0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.0	0.2	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	-0.4	-0.2	0.0
Pulse wave reflection index	0.0	0.1	0.2	0.1	0.1	-0.4
Number of full brothers	0.0	0.0	0.1	-0.0	-0.0	0.4
Mineral and other dietary supplements	0.0	0.0	0.1	0.0	-0.4	-0.1
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.3	-0.0	0.3
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.1	-0.2	-0.2

Hub : Genes

GPR19

Models

Trait associations