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chr12:63,544,209-67,434,487

Best TWAS P=5.27e-58 · Best GWAS P=2.94e-296 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LEMD3	0.04	0.01	enet	13	0.03	7.3e-05	-10.0	-8.1	6.3e-16	0.14	0.29	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMBIM4	0.26	0.23	lasso	11	0.25	2.0e-30	8.8	-8.4	4.0e-17	0.06	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SRGAP1	0.25	0.18	enet	17	0.19	3.3e-15	4.5	5.5	4.4e-08	0.03	0.82	0.17	TRUE
4	GTEx	Adipose Visceral Omentum	LEMD3	0.14	0.05	lasso	8	0.05	1.1e-03	-8.7	-10.0	1.5e-23	0.12	0.37	0.24	FALSE
5	GTEx	Artery Aorta	GNS	0.23	0.28	lasso	4	0.27	2.0e-15	7.9	7.9	3.0e-15	-0.04	1.00	0.00	FALSE
6	GTEx	Artery Aorta	TMBIM4	0.21	0.12	lasso	4	0.10	2.9e-06	8.0	8.7	2.3e-18	-0.06	0.99	0.00	FALSE
7	GTEx	Artery Tibial	GNS	0.24	0.24	lasso	7	0.25	5.9e-20	7.9	8.0	1.3e-15	-0.03	1.00	0.00	FALSE
8	GTEx	Brain Hippocampus	TMBIM4	0.32	0.22	lasso	2	0.29	1.7e-07	7.7	7.6	2.8e-14	-0.07	0.80	0.01	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	TMBIM4	0.27	0.23	enet	16	0.11	8.3e-04	8.7	9.5	2.0e-21	-0.05	0.55	0.03	FALSE
10	GTEx	Brain Putamen basal ganglia	TMBIM4	0.42	0.21	lasso	7	0.17	8.8e-05	8.7	5.6	2.0e-08	-0.10	0.14	0.18	FALSE
11	GTEx	Cells Transformed fibroblasts	LEMD3	0.09	0.10	lasso	3	0.09	4.4e-07	-9.2	-9.2	3.7e-20	0.11	0.97	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	XPOT	0.08	0.01	enet	9	0.02	1.0e-02	-2.3	5.6	1.8e-08	-0.01	0.07	0.34	FALSE
13	GTEx	Colon Sigmoid	TMBIM4	0.22	0.14	enet	18	0.11	8.1e-05	5.9	5.8	5.2e-09	-0.08	0.62	0.02	FALSE
14	GTEx	Colon Transverse	LEMD3	0.10	0.02	lasso	7	0.04	3.6e-03	-2.1	-7.6	2.8e-14	0.12	0.08	0.56	FALSE
15	GTEx	Esophagus Mucosa	GNS	0.13	0.00	enet	23	0.02	1.3e-02	7.9	8.5	1.3e-17	-0.03	0.15	0.13	FALSE
16	GTEx	Esophagus Muscularis	HELB	0.15	0.12	lasso	7	0.11	4.1e-07	1.0	-5.6	1.8e-08	-0.10	0.98	0.01	TRUE
17	GTEx	Esophagus Muscularis	GNS	0.23	0.22	lasso	1	0.21	5.5e-13	7.9	7.9	2.2e-15	-0.04	1.00	0.00	FALSE
18	GTEx	Esophagus Muscularis	LEMD3	0.09	0.09	enet	7	0.09	4.3e-06	-10.0	-9.6	7.9e-22	0.12	0.98	0.01	FALSE
19	GTEx	Heart Atrial Appendage	LEMD3	0.12	0.03	enet	12	0.06	7.5e-04	-8.7	-11.2	3.5e-29	0.12	0.02	0.94	TRUE
20	GTEx	Heart Atrial Appendage	RBMS1P1	0.17	0.03	lasso	11	0.04	7.3e-03	20.6	-16.1	5.3e-58	-0.41	0.07	0.39	TRUE
21	GTEx	Nerve Tibial	GNS	0.14	0.16	lasso	2	0.14	2.6e-10	7.9	7.9	2.6e-15	-0.04	1.00	0.00	FALSE
22	GTEx	Nerve Tibial	TMBIM4	0.20	0.16	lasso	6	0.19	2.1e-13	8.7	8.4	4.6e-17	-0.06	1.00	0.00	FALSE
23	GTEx	Nerve Tibial	LEMD3	0.12	0.14	enet	13	0.16	2.0e-11	-9.2	-10.4	3.3e-25	0.12	1.00	0.00	FALSE
24	GTEx	Nerve Tibial	SRGAP1	0.25	0.22	lasso	5	0.28	7.9e-20	4.5	5.5	4.8e-08	0.06	0.76	0.24	FALSE
25	GTEx	Pituitary	TMBIM4	0.42	0.27	lasso	6	0.26	4.2e-07	7.9	8.0	1.3e-15	-0.06	0.89	0.01	FALSE
26	GTEx	Skin Sun Exposed Lower leg	TMBIM4	0.16	0.13	lasso	5	0.13	9.8e-11	7.9	8.5	1.8e-17	-0.06	1.00	0.00	TRUE
27	GTEx	Spleen	TMBIM4	0.36	0.26	lasso	6	0.22	3.2e-06	8.8	9.6	7.5e-22	-0.06	0.72	0.02	FALSE
28	GTEx	Testis	LLPH	0.19	0.21	lasso	1	0.20	4.3e-09	7.7	7.7	9.3e-15	-0.07	0.98	0.00	FALSE
29	GTEx	Testis	TMBIM4	0.54	0.46	lasso	10	0.48	5.6e-24	8.7	9.1	9.8e-20	-0.03	1.00	0.00	FALSE
30	GTEx	Testis	LEMD3	0.15	0.15	lasso	7	0.16	1.9e-07	-7.6	-8.0	1.3e-15	0.14	0.23	0.69	FALSE
31	GTEx	Testis	SRGAP1	0.25	0.12	lasso	2	0.13	3.1e-06	4.4	5.2	2.1e-07	0.07	0.59	0.26	FALSE
32	METSIM	Adipose	GNS	0.10	0.13	lasso	2	0.13	7.7e-19	7.9	-7.7	1.1e-14	0.01	1.00	0.00	FALSE
33	METSIM	Adipose	TMBIM4	0.09	0.11	lasso	4	0.10	4.3e-14	8.7	-8.4	4.8e-17	0.03	1.00	0.00	FALSE
34	NTR	Blood	GNS	0.04	0.05	lasso	5	0.05	1.4e-14	8.0	-7.5	5.5e-14	0.00	1.00	0.00	FALSE
35	NTR	Blood	TBC1D30	0.01	0.00	bslmm	327	0.00	1.6e-02	-1.7	-9.7	4.6e-22	0.11	0.07	0.03	FALSE
36	NTR	Blood	TMBIM4	0.11	0.14	lasso	8	0.13	1.2e-40	8.7	-8.8	1.7e-18	0.03	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMBIM4	0.05	0.04	blup	68	0.03	7.0e-04	8.7	-6.5	1.0e-10	0.02	0.21	0.14	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLPH	0.05	0.09	enet	12	0.09	1.2e-18	8.8	7.7	9.4e-15	-0.04	0.56	0.44	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM4	0.10	0.12	enet	12	0.13	5.6e-26	8.9	-8.5	1.3e-17	0.02	0.51	0.49	FALSE
40	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMBIM4	0.17	0.15	blup	68	0.15	1.2e-07	8.7	-6.9	4.4e-12	0.02	0.61	0.38	TRUE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	LLPH	0.14	0.12	lasso	1	0.10	1.6e-06	8.8	8.8	1.5e-18	-0.03	0.57	0.42	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	TMBIM4	0.12	0.12	lasso	1	0.11	4.4e-07	8.7	-8.7	3.6e-18	0.03	0.58	0.40	FALSE
43	The Cancer Genome Atlas	Esophageal Carcinoma	TMBIM4	0.18	0.13	enet	15	0.14	2.4e-05	8.9	-6.8	1.0e-11	-0.01	0.22	0.22	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IRAK3	0.04	0.01	blup	86	0.01	1.5e-02	7.3	5.2	2.0e-07	-0.06	0.02	0.12	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LEMD3	0.02	0.02	blup	36	0.02	5.9e-03	-10.3	-10.2	2.3e-24	0.13	0.01	0.78	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLPH	0.04	0.01	blup	74	0.01	8.3e-03	7.3	8.7	5.1e-18	-0.07	0.08	0.46	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMBIM4	0.18	0.23	enet	27	0.23	7.8e-26	8.7	-7.6	2.6e-14	0.00	0.58	0.42	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNS	0.02	0.01	blup	38	0.02	1.7e-03	6.7	-7.4	1.6e-13	0.04	0.03	0.66	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LLPH	0.12	0.18	lasso	8	0.19	1.3e-20	8.7	8.7	2.8e-18	-0.04	0.60	0.40	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMBIM4	0.21	0.28	enet	22	0.28	1.3e-31	8.7	-10.0	1.0e-23	0.04	0.63	0.37	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GNS	0.05	0.03	blup	38	0.04	3.6e-03	8.6	-8.5	2.3e-17	0.02	0.01	0.88	TRUE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LLPH	0.17	0.16	enet	10	0.21	2.7e-12	8.7	6.9	6.8e-12	-0.03	0.58	0.42	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMBIM4	0.38	0.24	lasso	4	0.23	2.6e-13	8.7	-8.9	3.7e-19	0.03	0.63	0.37	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	LEMD3	0.06	0.01	blup	36	0.02	6.8e-04	-9.2	-6.2	5.3e-10	0.03	0.02	0.14	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	LLPH	0.16	0.20	lasso	7	0.20	1.8e-22	8.7	9.2	3.0e-20	-0.05	0.64	0.36	FALSE
56	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LLPH	0.14	0.11	lasso	3	0.11	8.5e-06	8.9	8.9	6.0e-19	-0.04	0.60	0.33	FALSE
57	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMBIM4	0.12	0.09	blup	68	0.11	1.0e-05	8.8	-7.3	3.8e-13	-0.01	0.49	0.42	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	LLPH	0.09	0.13	lasso	7	0.13	3.4e-15	8.7	8.0	9.7e-16	-0.04	0.62	0.38	TRUE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	TMBIM4	0.11	0.16	lasso	2	0.15	1.7e-17	8.7	-8.7	2.5e-18	0.03	0.60	0.40	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LLPH	0.04	0.03	blup	71	0.02	2.8e-03	5.5	9.0	3.1e-19	-0.06	0.33	0.34	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMBIM4	0.15	0.15	lasso	4	0.14	3.9e-16	8.7	-8.9	3.9e-19	0.02	0.62	0.38	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LLPH	0.05	0.05	lasso	8	0.03	2.4e-03	8.7	8.8	1.7e-18	-0.03	0.18	0.17	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMBIM4	0.15	0.13	enet	15	0.15	2.9e-10	7.9	-8.5	1.5e-17	0.06	0.75	0.25	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LLPH	0.19	0.11	blup	74	0.12	9.2e-06	8.0	9.8	1.5e-22	-0.04	0.49	0.40	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMBIM4	0.17	0.11	lasso	5	0.08	2.5e-04	8.7	-8.6	6.2e-18	0.03	0.41	0.41	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LLPH	0.25	0.24	enet	9	0.25	2.3e-10	7.9	9.7	2.8e-22	-0.05	0.57	0.43	TRUE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMBIM4	0.10	0.08	blup	65	0.08	3.1e-04	7.9	-7.3	3.3e-13	0.04	0.22	0.14	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	LLPH	0.24	0.26	lasso	4	0.26	2.0e-27	8.7	8.9	5.5e-19	-0.04	0.62	0.38	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMBIM4	0.25	0.29	lasso	2	0.29	4.8e-31	8.7	-8.9	6.0e-19	0.03	0.62	0.38	FALSE
70	The Cancer Genome Atlas	Rectum Adenocarcinoma	LLPH	0.15	0.10	lasso	3	0.08	5.1e-03	5.5	5.4	8.1e-08	-0.06	0.04	0.08	FALSE
71	The Cancer Genome Atlas	Rectum Adenocarcinoma	TMBIM4	0.21	0.08	enet	28	0.08	7.6e-03	7.9	-8.0	1.3e-15	0.02	0.02	0.07	FALSE
72	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMBIM4	0.16	0.14	lasso	3	0.12	1.9e-07	8.8	-8.1	6.1e-16	0.03	0.55	0.44	FALSE
73	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TMBIM4	0.22	0.08	blup	67	0.12	4.8e-04	8.9	-7.5	6.7e-14	0.00	0.03	0.23	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMBIM4	0.08	0.09	blup	63	0.10	1.2e-07	7.9	-9.3	1.2e-20	0.02	0.61	0.39	FALSE
75	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LLPH	0.39	0.32	lasso	8	0.31	1.3e-11	8.0	8.5	2.1e-17	-0.06	0.80	0.20	TRUE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMBIM4	0.09	0.05	lasso	2	0.06	4.6e-03	8.3	-10.2	2.4e-24	0.06	0.02	0.51	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	LLPH	0.35	0.45	lasso	4	0.46	1.1e-49	8.7	8.9	8.2e-19	-0.04	0.58	0.42	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	TMBIM4	0.26	0.34	lasso	5	0.33	8.2e-33	8.7	-8.9	7.2e-19	0.04	0.67	0.33	FALSE
79	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LLPH	0.12	0.12	enet	13	0.09	1.7e-03	8.8	9.3	9.6e-21	-0.05	0.10	0.32	FALSE