Hub : Genes

IRAK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Small Intestine Terminal Ileum	0.3370	0.1020	1.0e-03	0.124	NA	0.139	NA	0.044	1.1e-03	NA	5.4e-04	NA	3.8e-02
2	NTR	Blood	0.0371	0.0117	9.2e-06	0.013	0.012	0.013	0.012	0.005	3.0e-05	7.0e-05	2.7e-05	7.0e-05	5.6e-03
3	YFS	Blood	0.0895	0.0184	0.0e+00	0.032	0.068	0.075	0.069	0.061	1.2e-10	1.9e-21	2.3e-23	1.5e-21	2.9e-19
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0422	0.0251	8.1e-03	0.010	0.012	-0.002	NA	0.005	2.4e-02	1.5e-02	8.0e-01	NA	9.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.4	0.2	-0.6	0.4	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.5	0.7	-1.2	-0.9	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	0.8	0.9	0.1	-0.4
Depression (Nagel 2018)	0.3	0.5	1.0	0.6	-0.4	-0.6	1.0
Intelligence (Savage-Jansen 2018)	1.0	3.2	5.9	-2.4	-0.9	-1.7	1.8
Neuroticism (Nagel 2018)	0.1	0.3	1.0	0.1	-0.4	-1.0	0.2
Schizophrenia (2018)	0.6	1.2	2.2	0.7	-1.4	-1.5	0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	3.8	1.9	1.7	0.4	0.0
Worry (Nagel 2018)	0.0	0.1	0.2	0.1	0.3	-0.4	-0.1
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	0.2	1.4	0.8	-0.3
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.6	-0.5	-0.0	-0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	1.0	0.5	-0.3	0.6
Crohns Disease (2017)	0.6	1.3	2.3	0.9	-1.3	-0.3	1.5
Irritable Bowel Disease (IBD)	1.2	2.8	5.5	-0.0	-2.4	-1.7	1.7
Ulcerative Colitis (UC)	1.2	2.2	3.8	-0.6	-1.9	-1.8	1.2
Major Depression (MDD)	0.4	0.5	1.6	-1.3	-0.1	-0.4	-0.2
Reaction Time	0.4	0.7	2.1	-0.9	-0.4	0.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.6	-1.9	0.0	-0.5	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.6	2.1	3.7	1.6	0.8	1.9	-1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.4	0.6	1.7	-0.6	0.6	-0.3	-1.3
Bipolar Disorder (2011)	1.2	1.2	2.1	-0.3	-1.5	-1.1	1.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.2	0.1	-0.6	0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.7	0.9	0.3	0.4	0.4
Crohns Disease (2012)	0.1	0.2	0.9	0.9	0.1	-0.3	0.1
Mean Putamen Volume	1.0	1.1	2.2	-1.5	-1.4	-0.4	0.3
Fasting Glucose	0.8	1.0	2.2	1.5	-1.0	0.9	-0.1
HbA1C	0.2	0.2	0.3	0.6	0.5	-0.6	0.3
HDL Cholesterol	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1
LDL Cholesterol	0.3	0.5	0.9	0.8	1.0	-0.4	0.7
Lupus	0.1	0.2	0.6	-0.0	-0.3	-0.8	0.2
Neuroticism (2016)	0.8	1.2	3.3	-1.8	-0.5	-1.1	0.3
Primary Biliary Cirrhosis	0.7	1.0	1.5	-1.1	-1.2	-0.9	0.7
Rheumatoid Arthritis	0.2	0.3	1.0	-0.2	0.1	-0.6	1.0
Schizophrenia (2014)	0.3	0.7	1.6	1.3	-0.2	-1.0	0.5
Triglycerides	0.3	0.5	2.0	0.0	-0.1	1.4	0.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	0.8	0.2	-0.5	1.4
Ulcerative Colitis	0.6	0.9	1.8	-0.7	-1.1	-1.3	0.5
Blood Eosinophil Count	0.8	6.2	14.4	0.8	1.2	2.9	-3.8
Blood Platelet Count	0.2	1.9	7.1	0.2	-2.7	-0.2	-0.4
Blood Red Count	0.3	2.5	6.4	0.9	2.5	1.2	-1.3
Blood White Count	0.3	2.2	5.2	-0.2	-0.2	1.9	-2.3
Heel T-Score	0.2	1.4	3.0	0.5	-1.7	0.0	1.5
BMI	0.7	4.1	8.1	1.5	2.9	1.6	-1.9
Height	0.6	11.1	27.0	0.8	-2.9	-2.9	5.2
Waist Hip Ratio (WHR)	1.2	5.5	11.4	-1.2	-3.0	-0.5	-3.4
Systolic Blood Pressure	0.6	2.8	4.5	-2.1	-2.1	-0.8	1.4
Smoking Status	0.3	0.8	2.1	0.7	-0.6	0.5	-1.4
Allergy or Eczema	0.3	0.8	1.5	-0.8	-1.2	-0.9	0.1
Cardiovascular Disease	0.7	2.3	4.2	-2.0	-1.7	-0.9	1.1
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.1	-0.8	-0.6	-0.3
Respiratory disease	0.1	0.2	0.7	-0.1	-0.9	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.4	0.1	-1.6	0.4	0.2
Lung FEV1/FVC ratio	0.2	1.1	2.2	0.3	-1.5	-0.5	-1.4
Lung FVC	1.6	7.9	24.9	-1.0	-1.8	-5.0	1.7
Neuroticism	0.4	1.1	2.9	-0.3	-1.1	-1.7	-0.0
Chronotype (morning person)	0.5	1.1	1.9	1.2	0.9	1.4	-0.1
Hair Pigment	0.1	1.6	3.6	-0.0	-1.9	-1.5	0.9
Tanning	0.2	2.1	6.5	0.4	0.8	1.0	-2.5
Hand grip strength (left)	0.1	0.2	0.4	0.6	0.4	0.4	0.1
Number of treatments/medications taken	0.1	0.1	0.2	-0.3	-0.3	0.2	-0.4
Average weekly spirits intake	0.4	0.5	0.9	0.8	0.0	-0.5	-1.0
Sensitivity / hurt feelings	0.8	1.4	2.5	0.1	-1.6	-1.4	1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.3	1.1	-0.3	-0.7	0.7
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.4	0.3	0.5	-1.1
Relative age of first facial hair	0.2	0.4	1.2	-0.6	1.1	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.3	-1.7	-0.7	-1.8	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	0.9	0.0	-0.6	0.9
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	-1.0	-0.1	-0.0	0.1
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.5	-0.1	0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.8	0.7	1.8	1.9	-1.0
Angina	1.1	1.4	3.8	-0.3	-2.0	-1.2	-0.5
Medication for hormone replacement therapy	0.7	0.8	3.1	-1.8	0.1	0.3	-0.3
Vitamin and mineral supplements	0.2	0.3	0.6	-0.4	-0.8	0.4	-0.5
Supplements: Zinc	0.3	0.3	1.1	1.1	0.1	-0.1	0.2
Medication: Co-codamol	2.3	2.6	4.5	-0.6	-2.1	-1.8	1.6
Medication: Metformin	0.5	0.7	1.5	-0.8	-0.6	0.7	-1.2
Diabetes (father)	0.4	0.5	1.8	0.1	-0.3	0.5	1.3
Diabetes (mother)	0.8	1.1	2.0	0.2	-0.8	1.4	-1.3
Severe depression (siblings)	1.4	1.6	4.1	1.1	0.0	-1.0	2.0
Pack years adult smoking proportion	0.4	0.6	1.2	-1.0	-1.1	-0.4	0.4
Impedance of leg (right)	0.2	1.0	2.5	-0.7	-1.6	-0.8	0.4
Leg fat-free mass (left)	0.2	1.2	2.1	1.4	1.2	-0.1	1.1
Trunk fat percentage	1.5	6.0	12.9	1.9	3.6	2.1	-1.6
Hand grip strength (right)	0.2	0.6	1.2	-0.6	0.2	-1.1	0.9
Townsend deprivation index at recruitment	0.6	0.9	1.5	1.1	-0.5	-0.8	1.2
Current tobacco smoking	0.4	0.6	1.1	0.6	-0.7	0.8	-1.0
Average weekly fortified wine intake	1.0	1.1	2.2	1.3	-1.5	-0.7	-0.3
Maternal smoking around birth	0.4	0.6	1.9	-0.1	-1.4	0.1	-0.7
Fed-up feelings	0.6	1.1	1.4	0.8	1.0	-1.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.3	0.7	-0.3	-1.4	1.8
Relative age voice broke	0.3	0.5	1.6	-0.5	1.3	0.3	-0.3
Taking other prescription medications	0.0	0.1	0.2	-0.1	-0.4	0.1	0.2
Age when periods started (menarche)	0.6	1.4	2.7	0.6	0.8	-1.4	1.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	3.1	-1.4	-0.0	1.2	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	5.8	-1.2	-2.4	-1.3	2.0
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	5.1	1.5	0.7	0.7	-2.3
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.5	-0.0	0.1	-0.7
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.2	-0.9	-0.6	0.9
High blood pressure	0.8	2.2	6.9	-2.6	-1.0	-0.9	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-0.0	-1.3	-0.9	0.3
Multivitamins +/- minerals	0.4	0.6	1.9	0.0	1.4	0.6	-0.2
Stomach or abdominal pain in last month	0.2	0.3	1.0	-0.0	0.5	0.1	-1.0
Supplements: Glucosamine	0.3	0.4	0.7	0.8	0.8	0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.2	0.7	0.4	0.3
Medication: Atenolol	3.8	4.8	9.6	-1.3	1.8	2.2	-3.1
Medication: Levothyroxine sodium	0.4	0.7	2.3	-0.2	-0.1	0.6	-1.5
Sitting height	0.8	5.7	16.5	0.7	-1.6	-1.8	4.1
Chronic bronchitis/emphysema (father)	1.2	1.4	4.7	0.0	-0.3	2.2	-0.8
High blood pressure (mother)	0.4	0.6	1.1	0.0	1.0	0.6	-1.0
Body mass index (BMI)	1.3	5.6	11.9	1.1	3.5	1.9	-2.3
Impedance of leg (left)	0.1	0.5	1.1	-0.1	-1.1	-0.7	0.6
Leg predicted mass (left)	0.2	1.1	2.0	1.4	1.2	-0.1	1.0
Trunk fat mass	0.9	4.1	9.8	1.9	3.1	1.5	-0.9
Waist circumference	0.4	1.3	3.1	0.5	1.2	0.6	-1.7
Number of incorrect matches in round	0.9	1.4	3.6	-1.1	1.9	0.7	-0.7
Past tobacco smoking	0.4	0.8	1.5	0.6	1.1	1.2	0.3
Alcohol usually taken with meals	0.6	1.0	1.6	-1.3	-0.6	-1.3	0.7
Nervous feelings	0.3	0.5	1.4	-0.5	0.5	-1.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	1.2	-0.3	-1.1	0.9
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.4	-0.1	-0.0	-0.1
Hair/balding pattern: Pattern 2	2.2	2.8	7.2	0.6	0.3	2.7	-1.9
Had menopause	2.4	2.9	4.8	2.0	1.7	0.6	-2.2
Had other major operations	0.5	0.6	1.3	-1.2	0.1	0.3	-1.0
Forced vital capacity (FVC)	2.7	10.5	23.2	-0.8	-1.9	-4.8	3.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.7	-0.6	-1.6	0.5	1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	1.0	0.4	1.0	-0.5
Qualifications: None of the above	0.5	1.1	2.6	-1.3	-1.6	-0.1	-0.4
Financial difficulties in last 2 years	0.5	0.7	1.8	0.8	-0.3	1.3	-0.2
Mouth/teeth dental problems	0.5	0.8	1.7	-1.1	0.4	0.2	-1.3
Heart attack	1.1	1.4	5.2	0.1	-0.4	0.6	-2.3
Allergy	0.2	0.4	1.1	-0.2	1.0	0.7	-0.3
Pain all over the body in last month	1.6	1.7	6.3	-2.5	-0.3	0.3	-0.5
Diabetes (self-reported)	0.3	0.5	1.8	-0.3	-1.3	0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.2	0.8	-0.5	0.3
Medication: Ramipril	0.8	1.0	3.5	-1.9	-0.5	-0.4	-0.1
Medication: Simvastatin	0.0	0.0	0.1	-0.3	-0.0	0.2	0.1
Fluid intelligence score	0.4	0.8	1.3	-1.1	-0.7	-1.1	0.4
Illnesses of siblings	1.2	1.7	3.0	-1.7	0.9	-0.1	1.7
Neuroticism score	0.2	0.4	1.2	0.5	-0.0	-1.1	-0.2
Weight	0.4	1.9	5.4	1.4	2.3	0.4	0.2
Impedance of arm (right)	0.6	2.6	4.4	-0.8	-1.6	-1.6	2.1
Arm fat percentage (right)	1.1	4.3	10.3	1.3	3.2	1.7	-1.5
Trunk fat-free mass	0.2	1.3	2.4	0.9	-0.1	-1.3	1.6
Hip circumference	0.5	2.0	4.1	1.9	2.0	0.4	0.6
Time employed in main current job	0.5	0.6	1.0	-1.0	-0.7	-0.8	-0.3
Alcohol intake versus 10 years previously	0.7	1.1	2.2	-0.9	-1.5	-1.2	-0.1
Father’s age at death	0.4	0.5	1.8	0.1	0.6	-0.1	1.3
Worrier / anxious feelings	0.3	0.5	0.9	-0.7	0.8	0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.2	0.4	0.7	-0.3
Falls in the last year	0.3	0.3	0.6	0.8	0.5	0.7	-0.1
Hair/balding pattern: Pattern 3	1.3	2.0	3.2	-1.4	-1.1	-1.8	1.2
Number of live births	0.7	1.0	3.7	0.1	-0.6	0.1	-1.9
Forced expiratory volume in 1-second (FEV1)	2.9	9.9	23.1	-0.9	-2.2	-4.8	3.3
Pulse rate	1.7	2.9	6.2	0.0	-0.8	-2.2	2.5
Happiness	0.4	0.5	1.2	1.1	-0.1	-0.8	0.5
Noisy workplace	0.7	0.9	1.1	0.9	0.8	1.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.1	-0.8	0.3	-0.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.7	-1.6	-1.0	-0.4	1.4
Mouth/teeth dental problems: Dentures	1.1	1.8	3.8	0.0	-1.9	-0.3	1.8
Asthma	0.1	0.2	0.8	0.9	-0.2	-0.2	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.6	1.9	1.2	1.2	0.1
Medication: Cholesterol lowering	0.7	1.1	3.0	-1.7	-1.1	0.0	-0.2
Depression (self-reported)	0.8	1.0	2.1	-1.2	1.4	0.5	0.3
Medication: Lansoprazole	0.5	0.6	1.0	-0.0	1.0	0.8	-0.9
Prospective memory result	1.3	1.6	3.2	1.8	0.1	1.1	-1.4
Lung cancer (father)	0.0	0.0	0.1	-0.3	0.0	-0.2	0.2
Illnesses of mother	0.4	0.6	1.7	0.6	0.2	0.2	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	16.1	-1.0	-1.7	-4.0	2.1
Pulse wave Arterial Stiffness index	1.0	1.1	2.2	1.1	0.8	1.5	-0.6
Impedance of arm (left)	0.6	2.7	6.2	-0.1	-1.6	-1.4	2.5
Arm fat mass (right)	1.0	4.1	10.0	1.7	3.2	1.4	-1.2
Trunk predicted mass	0.2	1.3	2.6	0.9	-0.1	-1.3	1.6
Standing height	1.0	9.6	23.6	1.0	-2.0	-3.2	4.9
Length of working week for main job	1.0	1.1	1.7	0.7	0.9	1.3	-1.1
Exposure to tobacco smoke at home	0.8	0.9	2.2	-0.6	-1.5	-0.8	0.7
Breastfed as a baby	2.1	2.6	4.6	-2.1	-1.9	-1.4	-0.1
Tense / ‘highly strung’	0.8	1.3	2.3	1.5	1.3	-0.4	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	-0.2	1.1	1.3	-1.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	-0.4	-0.1	-0.1
Birth weight of first child	0.6	1.1	1.5	-1.1	1.1	-0.6	1.2
Peak expiratory flow (PEF)	1.8	4.1	6.6	-0.5	-1.9	-2.6	2.4
Pulse wave reflection index	1.5	1.8	4.1	1.2	0.4	2.0	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.3	0.4	0.0	-1.0	1.8
Loud music exposure frequency	0.3	0.4	1.1	0.3	0.2	-1.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.9	0.4	-1.2	-0.9	1.7
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.4	1.5	0.7	0.7	-1.0
Blood clot in the leg (DVT)	1.5	1.9	4.0	1.4	1.0	2.0	-0.9
Medication: Paracetamol	0.3	0.4	1.0	-1.0	0.1	-0.7	0.5
Headache pain in last month	0.0	0.1	0.2	-0.3	-0.2	0.4	0.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	8.1	2.8	0.7	0.2	-0.5
Glaucoma (self-reported)	0.2	0.2	0.6	-0.4	-0.2	-0.8	0.2
Gout (self-reported)	0.2	0.2	0.8	0.3	-0.2	-0.2	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	-0.7	-0.7	-0.7	-0.3
Medication: Amlodipine	0.6	0.8	1.2	-0.7	-1.1	-0.9	0.9
Medication: Ventolin 100micrograms inhaler	1.5	2.0	4.0	2.0	0.6	1.9	0.1
Birth weight	2.6	5.6	20.0	1.5	4.5	0.1	0.5
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.4	-0.1	-2.1	-1.6	-0.9
High blood pressure (siblings)	0.3	0.5	1.4	1.2	-0.3	-0.6	-0.2
Forced vital capacity (FVC), Best measure	1.8	6.6	17.2	-0.9	-1.2	-4.1	2.6
Body fat percentage	1.4	5.5	12.0	1.7	3.5	2.0	-1.9
Leg fat percentage (right)	1.3	4.9	9.8	0.9	3.1	1.9	-2.3
Arm fat-free mass (right)	0.2	1.2	3.7	1.9	0.9	-0.1	0.4
Exposure to tobacco smoke outside home	1.4	1.9	3.7	1.2	-1.2	-0.9	1.9
Comparative body size at age 10	0.9	2.5	7.1	1.1	2.7	0.4	-1.2
Number of full brothers	0.8	1.0	2.1	-0.1	0.4	1.3	-1.4
Worry too long after embarrassment	0.3	0.4	1.1	-0.1	0.1	-1.0	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.5	-0.7	-0.4	-0.2
Wheeze or whistling in the chest in last year	0.6	1.1	2.8	-1.0	0.1	0.8	-1.7
Number of children fathered	0.5	0.6	1.1	-0.9	-0.6	0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.5	0.9	0.1	0.8
Age at first live birth	0.1	0.2	0.4	-0.6	0.4	0.2	-0.4
Pulse wave peak to peak time	1.5	1.8	3.6	-0.9	-1.1	-1.9	1.2
Health satisfaction	0.5	0.6	1.9	0.4	-0.2	-1.4	0.4
Shortness of breath walking on level ground	0.5	0.5	1.8	0.5	1.3	0.1	-0.4
Qualifications: College or University degree	0.2	0.8	1.2	-0.6	-0.7	-1.1	0.9
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	0.3	0.3	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.5	-0.0	-0.3	0.2
Emphysema/chronic bronchitis	0.7	0.8	1.5	-0.5	-1.2	0.2	-1.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.1	-0.4	0.2	-0.8
Neck or shoulder pain in last month	0.3	0.4	1.1	-0.7	-0.1	0.3	-1.0
Medication: Blood pressure	1.5	2.6	9.4	-3.1	-0.7	0.1	0.6
Angina (self-reported)	1.1	1.5	3.7	-0.6	-1.9	-1.3	-0.6
Migraine (self-reported)	1.1	1.4	2.3	-1.4	-0.4	-1.1	1.5
Medication: Ibuprofen	1.5	1.8	3.7	1.9	1.8	0.6	0.1
Medication: Allopurinol	0.3	0.4	1.4	1.2	0.3	-0.1	-0.4
Medication: Omeprazole	0.4	0.5	0.9	0.2	-0.4	-1.0	0.8
Medication: Seretide 50 evohaler	1.0	1.1	2.7	-0.2	0.3	-1.7	1.3
Mean time to correctly identify matches	0.8	1.5	4.6	-1.1	-0.4	0.5	-2.1
Heart disease (mother)	0.1	0.2	0.4	-0.2	-0.0	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-0.4	-1.1	0.1	-1.1
Whole body fat mass	1.0	4.3	10.3	1.9	3.2	1.4	-1.1
Leg fat mass (right)	1.0	4.0	9.5	1.4	3.1	1.5	-1.6
Arm predicted mass (right)	0.2	1.2	3.7	1.9	1.0	-0.0	0.3
Pulse rate, automated reading	2.3	7.5	15.6	0.2	-2.0	-3.9	3.3
Alcohol intake frequency.	0.2	0.5	1.5	0.6	-1.2	0.1	-0.0
Comparative height size at age 10	0.4	2.2	3.7	1.9	-0.8	-0.9	1.9
Number of full sisters	0.2	0.3	0.6	-0.5	0.1	-0.5	0.8
Suffer from ‘nerves’	0.4	0.6	1.8	-0.1	-0.3	-1.3	0.8
Overall health rating	0.1	0.1	0.5	0.0	0.7	0.0	-0.3
Chest pain or discomfort	0.4	0.6	1.4	0.4	-0.6	-1.2	-0.6
Had major operations	0.4	0.5	1.4	-0.1	0.5	0.4	-1.2
Age at last live birth	0.1	0.2	0.6	-0.1	-0.4	-0.8	0.0
Family relationship satisfaction	0.4	0.5	1.1	0.9	-0.2	-1.0	0.3
Leg pain on walking	1.0	1.2	2.3	-0.5	1.5	1.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	4.0	1.6	0.7	2.0	-1.9
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.0	1.3	1.7	0.9	-1.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.2	0.5	1.5	-0.8	-0.6
Medication: Aspirin	0.3	0.4	1.0	0.2	-1.0	-0.3	-0.8
Supplements: Vitamin C	0.5	0.6	1.6	-0.3	-0.6	-1.3	0.7
Knee pain experienced in last month	0.3	0.5	1.0	0.4	-0.9	-0.4	1.0
Hypertension (Self-reported)	0.8	2.3	6.6	-2.6	-1.3	-0.9	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	7.1	2.7	2.0	1.6	0.0
Illnesses of father: Heart disease	0.2	0.3	0.5	0.1	0.6	0.7	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.2	0.4	0.1	0.8	-1.1
Smoking status: Previous	0.6	0.9	2.1	-1.0	-0.8	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.8	0.9	0.6	0.4	0.7
Whole body fat-free mass	0.2	1.1	1.9	1.4	0.6	-0.7	1.2
Leg fat-free mass (right)	0.3	1.6	2.9	1.7	1.2	-0.3	1.4
Arm fat percentage (left)	1.0	4.1	9.7	1.6	3.1	1.6	-1.4
Average weekly red wine intake	0.2	0.3	0.6	-0.8	-0.1	-0.8	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.4	0.0	0.1	0.7
Mood swings	0.2	0.3	1.2	0.3	1.1	0.2	-0.2
Loneliness, isolation	0.2	0.3	1.2	0.1	-0.2	-0.1	-1.1
Long-standing illness, disability or infirmity	0.4	0.6	1.7	0.4	0.5	1.3	-0.6
Ever had bowel cancer screening	0.5	0.5	1.4	-1.2	0.6	0.1	-0.6
Diabetes diagnosed by doctor	0.2	0.4	1.5	-0.3	-1.2	0.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	-0.9	-1.1	-0.7	0.6
Friendships satisfaction	0.3	0.4	0.9	-0.1	-0.3	-1.0	0.7
Qualifications: nursing, teaching	1.1	1.7	3.6	0.7	1.1	1.1	-1.9
Commuting to job workplace: Walk	0.5	0.5	1.0	0.1	0.4	0.9	1.0
Eye problems/disorders: Cataract	1.9	2.2	4.1	-1.1	0.9	1.7	-2.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	0.8	-0.2	-1.0	0.8
Medication for cholesterol	0.3	0.4	0.9	0.9	0.3	0.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.6	1.0	1.3	0.0	-0.5
Back pain experienced in last month	0.3	0.5	0.7	0.8	0.8	0.8	0.2
Mineral and other dietary supplements	0.4	0.5	1.4	-1.2	-0.1	-0.2	0.8
Breast cancer (self-reported)	1.0	1.2	2.8	-1.7	0.6	-0.9	-1.0
Asthma (self-reported)	0.1	0.2	0.6	0.8	-0.4	-0.2	-0.3
Osteoporosis (self-reported)	2.9	3.6	6.9	-0.4	2.3	2.6	-1.5
Osteoarthritis (self-reported)	0.7	0.9	2.8	-1.7	-0.7	0.3	-0.1
Medication: Aspirin	0.4	0.6	1.3	0.3	-1.1	-0.4	-0.8
Medication: Gliclazide	0.6	0.7	1.4	-0.9	0.2	0.6	-1.2
Illnesses of father: None of the above (group 1)	1.0	1.3	2.5	0.4	-1.4	-1.6	0.6
Smoking status: Current	0.5	0.7	1.1	1.1	-0.3	0.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	7.4	-0.4	-1.0	-2.7	1.9
Whole body water mass	0.2	1.1	2.2	1.5	0.6	-0.5	1.2
Leg predicted mass (right)	0.3	1.7	3.1	1.8	1.2	-0.3	1.4
Arm fat mass (left)	0.9	3.8	9.5	1.8	3.1	1.2	-1.0
Number of self-reported non-cancer illnesses	1.3	2.3	2.8	-1.6	-1.5	-1.3	1.7
Average weekly champagne plus white wine intake	1.2	1.7	3.5	1.0	-1.1	-1.9	1.1
Miserableness	0.4	0.7	2.5	1.6	0.1	-0.3	0.0
Guilty feelings	0.4	0.6	0.9	-0.9	-0.7	-0.6	-0.8
Wears glasses or contact lenses	0.8	0.9	2.8	-0.4	0.4	0.7	-1.7
Ever taken oral contraceptive pill	1.5	1.7	2.6	-0.1	-1.5	-1.6	1.4
Hearing aid user	0.5	0.6	2.2	0.2	-1.5	0.1	0.1
Mother’s age at death	0.4	0.6	0.9	0.6	-0.5	-0.9	0.9
Financial situation satisfaction	0.4	0.5	1.4	0.2	-1.2	-0.2	0.6
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.5	-1.2	0.5	0.1	0.2
Commuting to job workplace: Public transport	1.3	1.5	3.7	1.5	0.6	-0.1	1.9
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.3	0.5	-0.6	-0.2
Medication: Blood pressure	0.5	1.0	2.0	-0.8	-1.1	-1.4	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.1	-0.2	0.0	1.5	-1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.5	0.1	0.2	-1.1
High cholesterol (Self-reported)	0.4	0.7	1.2	-1.1	-0.7	-0.7	0.9
Medication: Bendroflumethiazide	1.1	1.6	3.2	-1.8	-1.4	-0.8	0.9
Medication: Paracetamol	0.5	0.8	1.9	-0.7	0.0	-1.4	0.8
Medication: Lisinopril	0.1	0.2	0.6	-0.8	0.2	-0.0	-0.4
Medication: Atorvastatin	0.7	0.8	2.1	-1.4	-0.4	-0.8	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.7	0.3	-0.5	0.2
Alcohol drinker status: Never	0.2	0.2	0.6	0.1	0.2	0.5	-0.8
Ever smoked	0.5	0.9	1.1	-1.1	-0.9	-0.8	-1.0
Basal metabolic rate	0.2	1.2	2.3	1.5	1.2	-0.4	1.0
Leg fat percentage (left)	1.6	5.7	12.2	1.5	3.5	2.0	-2.1
Arm fat-free mass (left)	0.2	1.1	2.7	1.6	1.4	-0.0	0.1
Number of operations (self-reported)	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1
Average weekly beer plus cider intake	1.9	2.7	6.1	2.5	1.5	1.1	-1.1
Irritability	0.9	1.5	4.1	-1.0	-0.3	-2.0	0.8
Risk taking	0.4	0.5	0.8	0.7	0.9	0.8	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	-0.7	0.5	0.0	1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.7	-0.9	0.8	0.8	1.3
Age started oral contraceptive pill	0.4	0.5	0.9	0.8	0.5	-1.0	0.5
Diastolic blood pressure, automated reading	0.2	0.6	1.0	0.8	1.0	1.0	-0.2
Ever depressed for a whole week	1.0	1.2	3.1	1.8	-0.5	0.8	0.9
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.3
Commuting to job workplace: Cycle	1.6	2.0	4.9	-0.5	-2.2	-1.2	1.1
Myopia	0.2	0.3	0.7	0.5	0.4	0.5	0.8
Vascular/heart problems diagnosed by doctor	0.9	2.4	6.8	2.6	1.4	1.0	-0.1
Cholesterol lowering medication	0.3	0.4	0.7	0.9	0.8	-0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.3	-0.5	-0.3	0.7
Pain experienced in last month	0.1	0.2	0.8	0.2	-0.2	-0.9	0.0
Supplements: Calcium	1.0	1.1	2.6	0.7	1.6	1.2	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	0.6	1.2	0.2	1.0
Heart attack/myocardial infarction (self-reported)	1.2	1.6	5.6	0.3	-0.2	0.7	-2.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.5	1.3	0.7	1.6	-0.8
Heart disease (siblings)	2.1	2.6	7.4	-0.1	-1.6	0.5	-2.7
Alcohol drinker status: Previous	0.5	0.5	0.9	0.5	1.0	0.7	0.7
Pack years of smoking	0.5	0.8	2.1	-1.5	-0.9	-0.1	0.4
Impedance of whole body	0.2	1.2	2.2	-0.2	-1.4	-0.8	1.5
Leg fat mass (left)	1.1	4.2	10.5	1.6	3.2	1.5	-1.3
Arm predicted mass (left)	0.2	0.9	2.3	1.5	1.1	-0.2	0.2