Hub : Genes

IRAK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Small Intestine Terminal Ileum 0.3370 0.1020 1.0e-03 0.124 NA 0.139 NA 0.044 1.1e-03 NA 5.4e-04 NA 3.8e-02
2 NTR Blood 0.0371 0.0117 9.2e-06 0.013 0.012 0.013 0.012 0.005 3.0e-05 7.0e-05 2.7e-05 7.0e-05 5.6e-03
3 YFS Blood 0.0895 0.0184 0.0e+00 0.032 0.068 0.075 0.069 0.061 1.2e-10 1.9e-21 2.3e-23 1.5e-21 2.9e-19
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0422 0.0251 8.1e-03 0.010 0.012 -0.002 NA 0.005 2.4e-02 1.5e-02 8.0e-01 NA 9.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.4 0.2 -0.6 0.4 0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 1.5 0.7 -1.2 -0.9 0.5
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 0.8 0.9 0.1 -0.4
Depression (Nagel 2018) 0.3 0.5 1.0 0.6 -0.4 -0.6 1.0
Intelligence (Savage-Jansen 2018) 1.0 3.2 5.9 -2.4 -0.9 -1.7 1.8
Neuroticism (Nagel 2018) 0.1 0.3 1.0 0.1 -0.4 -1.0 0.2
Schizophrenia (2018) 0.6 1.2 2.2 0.7 -1.4 -1.5 0.2
Schizophrenia vs Biploar Disorder 1.3 1.7 3.8 1.9 1.7 0.4 0.0
Worry (Nagel 2018) 0.0 0.1 0.2 0.1 0.3 -0.4 -0.1
Alzheimer’s Disease (in mother) 0.6 0.7 2.0 0.2 1.4 0.8 -0.3
Alzheimer’s Disease (in father) 0.1 0.2 0.3 0.6 -0.5 -0.0 -0.2
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 1.0 0.5 -0.3 0.6
Crohns Disease (2017) 0.6 1.3 2.3 0.9 -1.3 -0.3 1.5
Irritable Bowel Disease (IBD) 1.2 2.8 5.5 -0.0 -2.4 -1.7 1.7
Ulcerative Colitis (UC) 1.2 2.2 3.8 -0.6 -1.9 -1.8 1.2
Major Depression (MDD) 0.4 0.5 1.6 -1.3 -0.1 -0.4 -0.2
Reaction Time 0.4 0.7 2.1 -0.9 -0.4 0.0 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.6 -1.9 0.0 -0.5 -0.0
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.6 2.1 3.7 1.6 0.8 1.9 -1.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 1.7 -0.6 0.6 -0.3 -1.3
Bipolar Disorder (2011) 1.2 1.2 2.1 -0.3 -1.5 -1.1 1.1
Body Mass Index (BMI) (2010) 0.1 0.1 0.3 0.2 0.1 -0.6 0.2
Coronary Artery Disease (CAD) 0.2 0.3 0.7 0.9 0.3 0.4 0.4
Crohns Disease (2012) 0.1 0.2 0.9 0.9 0.1 -0.3 0.1
Mean Putamen Volume 1.0 1.1 2.2 -1.5 -1.4 -0.4 0.3
Fasting Glucose 0.8 1.0 2.2 1.5 -1.0 0.9 -0.1
HbA1C 0.2 0.2 0.3 0.6 0.5 -0.6 0.3
HDL Cholesterol 0.0 0.0 0.0 0.1 0.1 -0.2 -0.1
LDL Cholesterol 0.3 0.5 0.9 0.8 1.0 -0.4 0.7
Lupus 0.1 0.2 0.6 -0.0 -0.3 -0.8 0.2
Neuroticism (2016) 0.8 1.2 3.3 -1.8 -0.5 -1.1 0.3
Primary Biliary Cirrhosis 0.7 1.0 1.5 -1.1 -1.2 -0.9 0.7
Rheumatoid Arthritis 0.2 0.3 1.0 -0.2 0.1 -0.6 1.0
Schizophrenia (2014) 0.3 0.7 1.6 1.3 -0.2 -1.0 0.5
Triglycerides 0.3 0.5 2.0 0.0 -0.1 1.4 0.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 0.8 0.2 -0.5 1.4
Ulcerative Colitis 0.6 0.9 1.8 -0.7 -1.1 -1.3 0.5
Blood Eosinophil Count 0.8 6.2 14.4 0.8 1.2 2.9 -3.8
Blood Platelet Count 0.2 1.9 7.1 0.2 -2.7 -0.2 -0.4
Blood Red Count 0.3 2.5 6.4 0.9 2.5 1.2 -1.3
Blood White Count 0.3 2.2 5.2 -0.2 -0.2 1.9 -2.3
Heel T-Score 0.2 1.4 3.0 0.5 -1.7 0.0 1.5
BMI 0.7 4.1 8.1 1.5 2.9 1.6 -1.9
Height 0.6 11.1 27.0 0.8 -2.9 -2.9 5.2
Waist Hip Ratio (WHR) 1.2 5.5 11.4 -1.2 -3.0 -0.5 -3.4
Systolic Blood Pressure 0.6 2.8 4.5 -2.1 -2.1 -0.8 1.4
Smoking Status 0.3 0.8 2.1 0.7 -0.6 0.5 -1.4
Allergy or Eczema 0.3 0.8 1.5 -0.8 -1.2 -0.9 0.1
Cardiovascular Disease 0.7 2.3 4.2 -2.0 -1.7 -0.9 1.1
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.1 -0.8 -0.6 -0.3
Respiratory disease 0.1 0.2 0.7 -0.1 -0.9 -0.1 -0.4
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.4 0.1 -1.6 0.4 0.2
Lung FEV1/FVC ratio 0.2 1.1 2.2 0.3 -1.5 -0.5 -1.4
Lung FVC 1.6 7.9 24.9 -1.0 -1.8 -5.0 1.7
Neuroticism 0.4 1.1 2.9 -0.3 -1.1 -1.7 -0.0
Chronotype (morning person) 0.5 1.1 1.9 1.2 0.9 1.4 -0.1
Hair Pigment 0.1 1.6 3.6 -0.0 -1.9 -1.5 0.9
Tanning 0.2 2.1 6.5 0.4 0.8 1.0 -2.5
Hand grip strength (left) 0.1 0.2 0.4 0.6 0.4 0.4 0.1
Number of treatments/medications taken 0.1 0.1 0.2 -0.3 -0.3 0.2 -0.4
Average weekly spirits intake 0.4 0.5 0.9 0.8 0.0 -0.5 -1.0
Sensitivity / hurt feelings 0.8 1.4 2.5 0.1 -1.6 -1.4 1.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.3 1.1 -0.3 -0.7 0.7
Hearing difficulty/problems: Yes 0.3 0.4 1.2 0.4 0.3 0.5 -1.1
Relative age of first facial hair 0.2 0.4 1.2 -0.6 1.1 0.5 0.1
Other serious medical condition/disability diagnosed by doctor 1.5 2.0 3.3 -1.7 -0.7 -1.8 1.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.9 0.9 0.0 -0.6 0.9
Ever had hysterectomy (womb removed) 0.2 0.3 1.0 -1.0 -0.1 -0.0 0.1
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.5 -0.1 0.4 -0.4
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.8 0.7 1.8 1.9 -1.0
Angina 1.1 1.4 3.8 -0.3 -2.0 -1.2 -0.5
Medication for hormone replacement therapy 0.7 0.8 3.1 -1.8 0.1 0.3 -0.3
Vitamin and mineral supplements 0.2 0.3 0.6 -0.4 -0.8 0.4 -0.5
Supplements: Zinc 0.3 0.3 1.1 1.1 0.1 -0.1 0.2
Medication: Co-codamol 2.3 2.6 4.5 -0.6 -2.1 -1.8 1.6
Medication: Metformin 0.5 0.7 1.5 -0.8 -0.6 0.7 -1.2
Diabetes (father) 0.4 0.5 1.8 0.1 -0.3 0.5 1.3
Diabetes (mother) 0.8 1.1 2.0 0.2 -0.8 1.4 -1.3
Severe depression (siblings) 1.4 1.6 4.1 1.1 0.0 -1.0 2.0
Pack years adult smoking proportion 0.4 0.6 1.2 -1.0 -1.1 -0.4 0.4
Impedance of leg (right) 0.2 1.0 2.5 -0.7 -1.6 -0.8 0.4
Leg fat-free mass (left) 0.2 1.2 2.1 1.4 1.2 -0.1 1.1
Trunk fat percentage 1.5 6.0 12.9 1.9 3.6 2.1 -1.6
Hand grip strength (right) 0.2 0.6 1.2 -0.6 0.2 -1.1 0.9
Townsend deprivation index at recruitment 0.6 0.9 1.5 1.1 -0.5 -0.8 1.2
Current tobacco smoking 0.4 0.6 1.1 0.6 -0.7 0.8 -1.0
Average weekly fortified wine intake 1.0 1.1 2.2 1.3 -1.5 -0.7 -0.3
Maternal smoking around birth 0.4 0.6 1.9 -0.1 -1.4 0.1 -0.7
Fed-up feelings 0.6 1.1 1.4 0.8 1.0 -1.2 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.3 0.7 -0.3 -1.4 1.8
Relative age voice broke 0.3 0.5 1.6 -0.5 1.3 0.3 -0.3
Taking other prescription medications 0.0 0.1 0.2 -0.1 -0.4 0.1 0.2
Age when periods started (menarche) 0.6 1.4 2.7 0.6 0.8 -1.4 1.6
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 3.1 -1.4 -0.0 1.2 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 5.8 -1.2 -2.4 -1.3 2.0
Tinnitus: Yes, but not now, but have in the past 1.9 2.1 5.1 1.5 0.7 0.7 -2.3
Qualifications: CSEs or equivalent 0.1 0.2 0.4 0.5 -0.0 0.1 -0.7
Serious illness, injury or assault to yourself 0.4 0.5 0.8 -0.2 -0.9 -0.6 0.9
High blood pressure 0.8 2.2 6.9 -2.6 -1.0 -0.9 0.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.6 -0.0 -1.3 -0.9 0.3
Multivitamins +/- minerals 0.4 0.6 1.9 0.0 1.4 0.6 -0.2
Stomach or abdominal pain in last month 0.2 0.3 1.0 -0.0 0.5 0.1 -1.0
Supplements: Glucosamine 0.3 0.4 0.7 0.8 0.8 0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.2 0.7 0.4 0.3
Medication: Atenolol 3.8 4.8 9.6 -1.3 1.8 2.2 -3.1
Medication: Levothyroxine sodium 0.4 0.7 2.3 -0.2 -0.1 0.6 -1.5
Sitting height 0.8 5.7 16.5 0.7 -1.6 -1.8 4.1
Chronic bronchitis/emphysema (father) 1.2 1.4 4.7 0.0 -0.3 2.2 -0.8
High blood pressure (mother) 0.4 0.6 1.1 0.0 1.0 0.6 -1.0
Body mass index (BMI) 1.3 5.6 11.9 1.1 3.5 1.9 -2.3
Impedance of leg (left) 0.1 0.5 1.1 -0.1 -1.1 -0.7 0.6
Leg predicted mass (left) 0.2 1.1 2.0 1.4 1.2 -0.1 1.0
Trunk fat mass 0.9 4.1 9.8 1.9 3.1 1.5 -0.9
Waist circumference 0.4 1.3 3.1 0.5 1.2 0.6 -1.7
Number of incorrect matches in round 0.9 1.4 3.6 -1.1 1.9 0.7 -0.7
Past tobacco smoking 0.4 0.8 1.5 0.6 1.1 1.2 0.3
Alcohol usually taken with meals 0.6 1.0 1.6 -1.3 -0.6 -1.3 0.7
Nervous feelings 0.3 0.5 1.4 -0.5 0.5 -1.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.5 1.2 -0.3 -1.1 0.9
Hearing difficulty/problems with background noise 0.0 0.1 0.2 0.4 -0.1 -0.0 -0.1
Hair/balding pattern: Pattern 2 2.2 2.8 7.2 0.6 0.3 2.7 -1.9
Had menopause 2.4 2.9 4.8 2.0 1.7 0.6 -2.2
Had other major operations 0.5 0.6 1.3 -1.2 0.1 0.3 -1.0
Forced vital capacity (FVC) 2.7 10.5 23.2 -0.8 -1.9 -4.8 3.8
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.7 -0.6 -1.6 0.5 1.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.0 1.0 0.4 1.0 -0.5
Qualifications: None of the above 0.5 1.1 2.6 -1.3 -1.6 -0.1 -0.4
Financial difficulties in last 2 years 0.5 0.7 1.8 0.8 -0.3 1.3 -0.2
Mouth/teeth dental problems 0.5 0.8 1.7 -1.1 0.4 0.2 -1.3
Heart attack 1.1 1.4 5.2 0.1 -0.4 0.6 -2.3
Allergy 0.2 0.4 1.1 -0.2 1.0 0.7 -0.3
Pain all over the body in last month 1.6 1.7 6.3 -2.5 -0.3 0.3 -0.5
Diabetes (self-reported) 0.3 0.5 1.8 -0.3 -1.3 0.1 -0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 -0.2 0.8 -0.5 0.3
Medication: Ramipril 0.8 1.0 3.5 -1.9 -0.5 -0.4 -0.1
Medication: Simvastatin 0.0 0.0 0.1 -0.3 -0.0 0.2 0.1
Fluid intelligence score 0.4 0.8 1.3 -1.1 -0.7 -1.1 0.4
Illnesses of siblings 1.2 1.7 3.0 -1.7 0.9 -0.1 1.7
Neuroticism score 0.2 0.4 1.2 0.5 -0.0 -1.1 -0.2
Weight 0.4 1.9 5.4 1.4 2.3 0.4 0.2
Impedance of arm (right) 0.6 2.6 4.4 -0.8 -1.6 -1.6 2.1
Arm fat percentage (right) 1.1 4.3 10.3 1.3 3.2 1.7 -1.5
Trunk fat-free mass 0.2 1.3 2.4 0.9 -0.1 -1.3 1.6
Hip circumference 0.5 2.0 4.1 1.9 2.0 0.4 0.6
Time employed in main current job 0.5 0.6 1.0 -1.0 -0.7 -0.8 -0.3
Alcohol intake versus 10 years previously 0.7 1.1 2.2 -0.9 -1.5 -1.2 -0.1
Father’s age at death 0.4 0.5 1.8 0.1 0.6 -0.1 1.3
Worrier / anxious feelings 0.3 0.5 0.9 -0.7 0.8 0.1 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.2 0.4 0.7 -0.3
Falls in the last year 0.3 0.3 0.6 0.8 0.5 0.7 -0.1
Hair/balding pattern: Pattern 3 1.3 2.0 3.2 -1.4 -1.1 -1.8 1.2
Number of live births 0.7 1.0 3.7 0.1 -0.6 0.1 -1.9
Forced expiratory volume in 1-second (FEV1) 2.9 9.9 23.1 -0.9 -2.2 -4.8 3.3
Pulse rate 1.7 2.9 6.2 0.0 -0.8 -2.2 2.5
Happiness 0.4 0.5 1.2 1.1 -0.1 -0.8 0.5
Noisy workplace 0.7 0.9 1.1 0.9 0.8 1.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.1 -0.8 0.3 -0.3 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.7 -1.6 -1.0 -0.4 1.4
Mouth/teeth dental problems: Dentures 1.1 1.8 3.8 0.0 -1.9 -0.3 1.8
Asthma 0.1 0.2 0.8 0.9 -0.2 -0.2 0.0
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.6 1.9 1.2 1.2 0.1
Medication: Cholesterol lowering 0.7 1.1 3.0 -1.7 -1.1 0.0 -0.2
Depression (self-reported) 0.8 1.0 2.1 -1.2 1.4 0.5 0.3
Medication: Lansoprazole 0.5 0.6 1.0 -0.0 1.0 0.8 -0.9
Prospective memory result 1.3 1.6 3.2 1.8 0.1 1.1 -1.4
Lung cancer (father) 0.0 0.0 0.1 -0.3 0.0 -0.2 0.2
Illnesses of mother 0.4 0.6 1.7 0.6 0.2 0.2 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.1 16.1 -1.0 -1.7 -4.0 2.1
Pulse wave Arterial Stiffness index 1.0 1.1 2.2 1.1 0.8 1.5 -0.6
Impedance of arm (left) 0.6 2.7 6.2 -0.1 -1.6 -1.4 2.5
Arm fat mass (right) 1.0 4.1 10.0 1.7 3.2 1.4 -1.2
Trunk predicted mass 0.2 1.3 2.6 0.9 -0.1 -1.3 1.6
Standing height 1.0 9.6 23.6 1.0 -2.0 -3.2 4.9
Length of working week for main job 1.0 1.1 1.7 0.7 0.9 1.3 -1.1
Exposure to tobacco smoke at home 0.8 0.9 2.2 -0.6 -1.5 -0.8 0.7
Breastfed as a baby 2.1 2.6 4.6 -2.1 -1.9 -1.4 -0.1
Tense / ‘highly strung’ 0.8 1.3 2.3 1.5 1.3 -0.4 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 -0.2 1.1 1.3 -1.0
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.4 -0.4 -0.1 -0.1
Birth weight of first child 0.6 1.1 1.5 -1.1 1.1 -0.6 1.2
Peak expiratory flow (PEF) 1.8 4.1 6.6 -0.5 -1.9 -2.6 2.4
Pulse wave reflection index 1.5 1.8 4.1 1.2 0.4 2.0 -1.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.3 0.4 0.0 -1.0 1.8
Loud music exposure frequency 0.3 0.4 1.1 0.3 0.2 -1.1 0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.9 0.4 -1.2 -0.9 1.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.4 1.5 0.7 0.7 -1.0
Blood clot in the leg (DVT) 1.5 1.9 4.0 1.4 1.0 2.0 -0.9
Medication: Paracetamol 0.3 0.4 1.0 -1.0 0.1 -0.7 0.5
Headache pain in last month 0.0 0.1 0.2 -0.3 -0.2 0.4 0.1
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 8.1 2.8 0.7 0.2 -0.5
Glaucoma (self-reported) 0.2 0.2 0.6 -0.4 -0.2 -0.8 0.2
Gout (self-reported) 0.2 0.2 0.8 0.3 -0.2 -0.2 -0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 -0.7 -0.7 -0.7 -0.3
Medication: Amlodipine 0.6 0.8 1.2 -0.7 -1.1 -0.9 0.9
Medication: Ventolin 100micrograms inhaler 1.5 2.0 4.0 2.0 0.6 1.9 0.1
Birth weight 2.6 5.6 20.0 1.5 4.5 0.1 0.5
Chronic bronchitis/emphysema (mother) 1.7 2.0 4.4 -0.1 -2.1 -1.6 -0.9
High blood pressure (siblings) 0.3 0.5 1.4 1.2 -0.3 -0.6 -0.2
Forced vital capacity (FVC), Best measure 1.8 6.6 17.2 -0.9 -1.2 -4.1 2.6
Body fat percentage 1.4 5.5 12.0 1.7 3.5 2.0 -1.9
Leg fat percentage (right) 1.3 4.9 9.8 0.9 3.1 1.9 -2.3
Arm fat-free mass (right) 0.2 1.2 3.7 1.9 0.9 -0.1 0.4
Exposure to tobacco smoke outside home 1.4 1.9 3.7 1.2 -1.2 -0.9 1.9
Comparative body size at age 10 0.9 2.5 7.1 1.1 2.7 0.4 -1.2
Number of full brothers 0.8 1.0 2.1 -0.1 0.4 1.3 -1.4
Worry too long after embarrassment 0.3 0.4 1.1 -0.1 0.1 -1.0 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.5 -0.5 -0.7 -0.4 -0.2
Wheeze or whistling in the chest in last year 0.6 1.1 2.8 -1.0 0.1 0.8 -1.7
Number of children fathered 0.5 0.6 1.1 -0.9 -0.6 0.4 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.8 0.5 0.9 0.1 0.8
Age at first live birth 0.1 0.2 0.4 -0.6 0.4 0.2 -0.4
Pulse wave peak to peak time 1.5 1.8 3.6 -0.9 -1.1 -1.9 1.2
Health satisfaction 0.5 0.6 1.9 0.4 -0.2 -1.4 0.4
Shortness of breath walking on level ground 0.5 0.5 1.8 0.5 1.3 0.1 -0.4
Qualifications: College or University degree 0.2 0.8 1.2 -0.6 -0.7 -1.1 0.9
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.3 0.3 0.3 0.4
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.5 -0.0 -0.3 0.2
Emphysema/chronic bronchitis 0.7 0.8 1.5 -0.5 -1.2 0.2 -1.1
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 -0.1 -0.4 0.2 -0.8
Neck or shoulder pain in last month 0.3 0.4 1.1 -0.7 -0.1 0.3 -1.0
Medication: Blood pressure 1.5 2.6 9.4 -3.1 -0.7 0.1 0.6
Angina (self-reported) 1.1 1.5 3.7 -0.6 -1.9 -1.3 -0.6
Migraine (self-reported) 1.1 1.4 2.3 -1.4 -0.4 -1.1 1.5
Medication: Ibuprofen 1.5 1.8 3.7 1.9 1.8 0.6 0.1
Medication: Allopurinol 0.3 0.4 1.4 1.2 0.3 -0.1 -0.4
Medication: Omeprazole 0.4 0.5 0.9 0.2 -0.4 -1.0 0.8
Medication: Seretide 50 evohaler 1.0 1.1 2.7 -0.2 0.3 -1.7 1.3
Mean time to correctly identify matches 0.8 1.5 4.6 -1.1 -0.4 0.5 -2.1
Heart disease (mother) 0.1 0.2 0.4 -0.2 -0.0 -0.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.3 -0.4 -1.1 0.1 -1.1
Whole body fat mass 1.0 4.3 10.3 1.9 3.2 1.4 -1.1
Leg fat mass (right) 1.0 4.0 9.5 1.4 3.1 1.5 -1.6
Arm predicted mass (right) 0.2 1.2 3.7 1.9 1.0 -0.0 0.3
Pulse rate, automated reading 2.3 7.5 15.6 0.2 -2.0 -3.9 3.3
Alcohol intake frequency. 0.2 0.5 1.5 0.6 -1.2 0.1 -0.0
Comparative height size at age 10 0.4 2.2 3.7 1.9 -0.8 -0.9 1.9
Number of full sisters 0.2 0.3 0.6 -0.5 0.1 -0.5 0.8
Suffer from ‘nerves’ 0.4 0.6 1.8 -0.1 -0.3 -1.3 0.8
Overall health rating 0.1 0.1 0.5 0.0 0.7 0.0 -0.3
Chest pain or discomfort 0.4 0.6 1.4 0.4 -0.6 -1.2 -0.6
Had major operations 0.4 0.5 1.4 -0.1 0.5 0.4 -1.2
Age at last live birth 0.1 0.2 0.6 -0.1 -0.4 -0.8 0.0
Family relationship satisfaction 0.4 0.5 1.1 0.9 -0.2 -1.0 0.3
Leg pain on walking 1.0 1.2 2.3 -0.5 1.5 1.1 -1.0
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.7 4.0 1.6 0.7 2.0 -1.9
Commuting to job workplace: Car/motor vehicle 1.8 2.0 3.0 1.3 1.7 0.9 -1.6
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.2 0.5 1.5 -0.8 -0.6
Medication: Aspirin 0.3 0.4 1.0 0.2 -1.0 -0.3 -0.8
Supplements: Vitamin C 0.5 0.6 1.6 -0.3 -0.6 -1.3 0.7
Knee pain experienced in last month 0.3 0.5 1.0 0.4 -0.9 -0.4 1.0
Hypertension (Self-reported) 0.8 2.3 6.6 -2.6 -1.3 -0.9 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 7.1 2.7 2.0 1.6 0.0
Illnesses of father: Heart disease 0.2 0.3 0.5 0.1 0.6 0.7 0.3
Illnesses of siblings: Diabetes 0.4 0.5 1.2 0.4 0.1 0.8 -1.1
Smoking status: Previous 0.6 0.9 2.1 -1.0 -0.8 -1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 0.8 0.9 0.6 0.4 0.7
Whole body fat-free mass 0.2 1.1 1.9 1.4 0.6 -0.7 1.2
Leg fat-free mass (right) 0.3 1.6 2.9 1.7 1.2 -0.3 1.4
Arm fat percentage (left) 1.0 4.1 9.7 1.6 3.1 1.6 -1.4
Average weekly red wine intake 0.2 0.3 0.6 -0.8 -0.1 -0.8 0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 0.4 0.0 0.1 0.7
Mood swings 0.2 0.3 1.2 0.3 1.1 0.2 -0.2
Loneliness, isolation 0.2 0.3 1.2 0.1 -0.2 -0.1 -1.1
Long-standing illness, disability or infirmity 0.4 0.6 1.7 0.4 0.5 1.3 -0.6
Ever had bowel cancer screening 0.5 0.5 1.4 -1.2 0.6 0.1 -0.6
Diabetes diagnosed by doctor 0.2 0.4 1.5 -0.3 -1.2 0.1 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.2 -0.9 -1.1 -0.7 0.6
Friendships satisfaction 0.3 0.4 0.9 -0.1 -0.3 -1.0 0.7
Qualifications: nursing, teaching 1.1 1.7 3.6 0.7 1.1 1.1 -1.9
Commuting to job workplace: Walk 0.5 0.5 1.0 0.1 0.4 0.9 1.0
Eye problems/disorders: Cataract 1.9 2.2 4.1 -1.1 0.9 1.7 -2.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.0 0.8 -0.2 -1.0 0.8
Medication for cholesterol 0.3 0.4 0.9 0.9 0.3 0.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.6 1.0 1.3 0.0 -0.5
Back pain experienced in last month 0.3 0.5 0.7 0.8 0.8 0.8 0.2
Mineral and other dietary supplements 0.4 0.5 1.4 -1.2 -0.1 -0.2 0.8
Breast cancer (self-reported) 1.0 1.2 2.8 -1.7 0.6 -0.9 -1.0
Asthma (self-reported) 0.1 0.2 0.6 0.8 -0.4 -0.2 -0.3
Osteoporosis (self-reported) 2.9 3.6 6.9 -0.4 2.3 2.6 -1.5
Osteoarthritis (self-reported) 0.7 0.9 2.8 -1.7 -0.7 0.3 -0.1
Medication: Aspirin 0.4 0.6 1.3 0.3 -1.1 -0.4 -0.8
Medication: Gliclazide 0.6 0.7 1.4 -0.9 0.2 0.6 -1.2
Illnesses of father: None of the above (group 1) 1.0 1.3 2.5 0.4 -1.4 -1.6 0.6
Smoking status: Current 0.5 0.7 1.1 1.1 -0.3 0.9 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 7.4 -0.4 -1.0 -2.7 1.9
Whole body water mass 0.2 1.1 2.2 1.5 0.6 -0.5 1.2
Leg predicted mass (right) 0.3 1.7 3.1 1.8 1.2 -0.3 1.4
Arm fat mass (left) 0.9 3.8 9.5 1.8 3.1 1.2 -1.0
Number of self-reported non-cancer illnesses 1.3 2.3 2.8 -1.6 -1.5 -1.3 1.7
Average weekly champagne plus white wine intake 1.2 1.7 3.5 1.0 -1.1 -1.9 1.1
Miserableness 0.4 0.7 2.5 1.6 0.1 -0.3 0.0
Guilty feelings 0.4 0.6 0.9 -0.9 -0.7 -0.6 -0.8
Wears glasses or contact lenses 0.8 0.9 2.8 -0.4 0.4 0.7 -1.7
Ever taken oral contraceptive pill 1.5 1.7 2.6 -0.1 -1.5 -1.6 1.4
Hearing aid user 0.5 0.6 2.2 0.2 -1.5 0.1 0.1
Mother’s age at death 0.4 0.6 0.9 0.6 -0.5 -0.9 0.9
Financial situation satisfaction 0.4 0.5 1.4 0.2 -1.2 -0.2 0.6
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.5 -1.2 0.5 0.1 0.2
Commuting to job workplace: Public transport 1.3 1.5 3.7 1.5 0.6 -0.1 1.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 0.3 0.5 -0.6 -0.2
Medication: Blood pressure 0.5 1.0 2.0 -0.8 -1.1 -1.4 0.4
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.1 -0.2 0.0 1.5 -1.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 0.5 0.1 0.2 -1.1
High cholesterol (Self-reported) 0.4 0.7 1.2 -1.1 -0.7 -0.7 0.9
Medication: Bendroflumethiazide 1.1 1.6 3.2 -1.8 -1.4 -0.8 0.9
Medication: Paracetamol 0.5 0.8 1.9 -0.7 0.0 -1.4 0.8
Medication: Lisinopril 0.1 0.2 0.6 -0.8 0.2 -0.0 -0.4
Medication: Atorvastatin 0.7 0.8 2.1 -1.4 -0.4 -0.8 -0.7
Illnesses of father: High blood pressure 0.2 0.2 0.4 -0.7 0.3 -0.5 0.2
Alcohol drinker status: Never 0.2 0.2 0.6 0.1 0.2 0.5 -0.8
Ever smoked 0.5 0.9 1.1 -1.1 -0.9 -0.8 -1.0
Basal metabolic rate 0.2 1.2 2.3 1.5 1.2 -0.4 1.0
Leg fat percentage (left) 1.6 5.7 12.2 1.5 3.5 2.0 -2.1
Arm fat-free mass (left) 0.2 1.1 2.7 1.6 1.4 -0.0 0.1
Number of operations (self-reported) 0.0 0.0 0.0 -0.2 -0.1 -0.1 0.1
Average weekly beer plus cider intake 1.9 2.7 6.1 2.5 1.5 1.1 -1.1
Irritability 0.9 1.5 4.1 -1.0 -0.3 -2.0 0.8
Risk taking 0.4 0.5 0.8 0.7 0.9 0.8 -0.4
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.3 -0.7 0.5 0.0 1.1
Fractured/broken bones in last 5 years 0.7 0.9 1.7 -0.9 0.8 0.8 1.3
Age started oral contraceptive pill 0.4 0.5 0.9 0.8 0.5 -1.0 0.5
Diastolic blood pressure, automated reading 0.2 0.6 1.0 0.8 1.0 1.0 -0.2
Ever depressed for a whole week 1.0 1.2 3.1 1.8 -0.5 0.8 0.9
Unable to work because of sickness or disability 0.1 0.1 0.1 -0.2 -0.2 0.3 -0.3
Commuting to job workplace: Cycle 1.6 2.0 4.9 -0.5 -2.2 -1.2 1.1
Myopia 0.2 0.3 0.7 0.5 0.4 0.5 0.8
Vascular/heart problems diagnosed by doctor 0.9 2.4 6.8 2.6 1.4 1.0 -0.1
Cholesterol lowering medication 0.3 0.4 0.7 0.9 0.8 -0.4 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.3 -0.5 -0.3 0.7
Pain experienced in last month 0.1 0.2 0.8 0.2 -0.2 -0.9 0.0
Supplements: Calcium 1.0 1.1 2.6 0.7 1.6 1.2 0.3
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 0.6 1.2 0.2 1.0
Heart attack/myocardial infarction (self-reported) 1.2 1.6 5.6 0.3 -0.2 0.7 -2.4
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.5 1.3 0.7 1.6 -0.8
Heart disease (siblings) 2.1 2.6 7.4 -0.1 -1.6 0.5 -2.7
Alcohol drinker status: Previous 0.5 0.5 0.9 0.5 1.0 0.7 0.7
Pack years of smoking 0.5 0.8 2.1 -1.5 -0.9 -0.1 0.4
Impedance of whole body 0.2 1.2 2.2 -0.2 -1.4 -0.8 1.5
Leg fat mass (left) 1.1 4.2 10.5 1.6 3.2 1.5 -1.3
Arm predicted mass (left) 0.2 0.9 2.3 1.5 1.1 -0.2 0.2