TWAS hub - XPOT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0840	0.0370	0.00200	0.009	NA	0.021	NA	0.016	6.5e-02	NA	1.0e-02	NA	1.9e-02
2	GTEx	Nerve Tibial	0.1140	0.0431	0.00089	0.056	NA	0.072	NA	0.070	8.4e-05	NA	8.6e-06	NA	1.1e-05
3	TCGA	Brain Lower Grade Glioma	0.0206	0.0129	0.00610	0.013	0.019	0.016	NA	0.019	1.2e-02	0.0027	4.9e-03	NA	2.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heart disease (mother)	7.2	8.8	13.8	2.3	3.7	2.7
Frequency of depressed mood in last 2 weeks	5.6	7.8	12.9	-0.8	-3.6	-3.1
Commuting to job workplace: Cycle	5.2	6.2	9.5	1.9	3.1	2.4
Loneliness, isolation	4.7	6.5	13.4	-1.6	-3.7	-1.9
Triglycerides	4.6	7.6	12.0	2.0	3.5	2.6
Eye problems/disorders: None of the above	4.5	5.2	12.6	-1.7	-3.5	-0.4
Medication: Levothyroxine sodium	4.1	6.9	8.3	2.9	2.4	2.6
Medication: Co-codamol	3.8	4.4	10.8	-0.8	-1.4	-3.3
Fed-up feelings	3.7	6.7	9.6	-1.2	-3.0	-3.1
Depression (self-reported)	3.6	4.3	7.3	-1.1	-2.1	-2.7
Guilty feelings	3.4	5.2	9.4	-2.3	-1.0	-3.1
Supplements: Zinc	3.3	3.6	4.5	2.0	1.5	2.1
Sensitivity / hurt feelings	3.1	5.3	10.1	-1.1	-3.2	-2.1
Blood Platelet Count	3.0	35.1	57.0	0.8	-7.5	-6.9
Worrier / anxious feelings	2.9	5.6	8.6	-1.0	-2.9	-2.7
Illnesses of mother	2.9	3.6	7.0	-1.4	-2.7	-1.3
Hypothyroidism/myxoedema (self-reported)	2.9	5.6	9.8	1.6	2.1	3.1
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	5.8	-2.1	0.1	-2.4
Lung FEV1/FVC ratio	2.7	13.5	19.5	4.4	2.7	3.6
Peak expiratory flow (PEF)	2.7	6.3	14.6	3.8	1.4	1.5
Neuroticism score	2.6	5.4	8.6	-0.7	-2.9	-2.7
Medication: Seretide 50 evohaler	2.6	3.0	5.4	0.5	-1.9	-2.3
Hypothyroidism (self reported)	2.5	5.7	9.4	1.8	2.1	3.1
Depression (Nagel 2018)	2.4	3.6	6.0	-0.5	-2.1	-2.5
Neuroticism	2.4	5.7	8.7	-1.5	-2.5	-3.0
Shortness of breath walking on level ground	2.4	2.8	7.7	0.2	-2.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.6	7.4	0.4	-1.8	-2.7
Hair/balding pattern: Pattern 4	2.3	5.5	10.4	-0.7	2.4	3.2
Pain type(s) experienced in last month: Hip pain	2.3	2.9	6.6	-1.2	-2.6	-0.8
Severe depression (siblings)	2.2	2.5	5.6	-0.0	2.4	-1.4
Medication: Lisinopril	2.2	2.9	6.2	-0.2	-1.6	-2.5
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.4	2.1	-0.3	1.7
LDL Cholesterol	2.1	3.4	9.7	0.6	3.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.4	-0.5	-2.5	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	15.4	3.9	1.3	1.6
Medication: Paracetamol	2.1	3.5	8.9	-3.0	-0.9	-0.8
Hair/balding pattern: Pattern 3	2.0	2.9	3.2	1.7	1.8	1.7
Chronic bronchitis/emphysema (mother)	2.0	2.4	5.8	-1.1	-2.4	-0.2
Medication: Bendroflumethiazide	2.0	3.0	5.6	0.5	-1.8	-2.4
Average weekly spirits intake	1.9	2.3	3.6	1.9	-0.2	1.8
Eye problems/disorders: Cataract	1.9	2.2	3.6	1.7	1.9	-0.6
Illnesses of father: High blood pressure	1.9	2.4	6.8	-0.4	-0.4	-2.6
Unable to work because of sickness or disability	1.9	2.5	4.3	-1.1	-2.1	-1.3
Neuroticism (Nagel 2018)	1.8	4.2	9.4	-0.7	-1.7	-3.1
Qualifications: None of the above	1.8	4.0	5.8	-2.1	-2.4	-1.4
Trunk fat-free mass	1.8	10.3	19.3	3.2	1.1	4.4
Trunk predicted mass	1.8	10.4	19.6	3.2	1.0	4.4
Pulse rate, automated reading	1.8	5.9	11.2	-3.3	-2.2	1.3
Basal cell carcinoma (self-reported)	1.8	2.2	4.8	-1.0	-0.8	-2.2
Depressed Affect (Nagel 2018)	1.7	3.7	5.6	-0.9	-2.1	-2.4
Hearing difficulty/problems with background noise	1.7	2.7	4.2	1.9	0.5	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	4.6	1.4	-1.3	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	6.0	2.5	-0.1	0.3
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.9	0.9	1.6	1.7
Arm fat-free mass (left)	1.7	8.5	19.0	2.5	0.5	4.4
Taking other prescription medications	1.6	2.5	5.5	1.0	-1.0	-2.4
Pain all over the body in last month	1.6	1.7	3.3	0.0	-1.3	-1.8
Medication: Paracetamol	1.6	2.5	7.2	-2.7	-0.5	-0.3
Worry (Nagel 2018)	1.5	3.3	7.0	-0.4	-1.6	-2.7
Crohns Disease (2017)	1.5	3.2	5.4	-2.1	-0.0	-2.3
Crohns Disease (2012)	1.5	2.4	5.7	-1.2	0.1	-2.4
Pulse rate	1.5	2.5	3.6	-1.9	-1.8	-0.6
Standing height	1.5	14.9	23.7	4.9	1.1	4.5
Whole body fat-free mass	1.5	8.6	16.8	2.9	0.9	4.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	5.1	-2.3	-0.0	-0.5
Whole body water mass	1.5	8.8	17.1	2.9	0.9	4.1
Major Depression (MDD)	1.4	1.7	3.2	-0.4	-1.3	-1.8
Rheumatoid Arthritis	1.4	1.9	4.5	0.2	-1.1	-2.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.5	0.5	-1.4	-1.6
Stomach or abdominal pain in last month	1.4	1.7	2.4	-0.9	-1.4	-1.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.4	1.8	0.3	1.3
Financial difficulties in last 2 years	1.4	1.9	4.1	-0.7	-1.0	-2.0
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	10.3	3.2	1.7	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.6	-0.6	-2.1	-0.2
Supplements: Vitamin C	1.4	1.6	4.7	2.2	-0.4	-0.2
Asthma (self-reported)	1.4	2.8	4.8	-1.3	-1.4	-2.2
Smoking status: Current	1.4	2.2	3.5	-1.6	-0.8	1.9
Supplements: Calcium	1.4	1.5	2.5	1.6	1.1	0.9
Arm predicted mass (left)	1.4	7.1	16.1	2.2	0.6	4.0
Lupus	1.3	2.0	2.8	-0.8	-1.6	-1.7
Current tobacco smoking	1.3	2.1	4.3	-1.4	-0.4	2.1
Mouth/teeth dental problems	1.3	2.0	3.4	-0.2	1.6	1.9
Arm predicted mass (right)	1.3	6.5	12.6	2.5	0.9	3.6
Basal metabolic rate	1.3	7.3	15.7	2.5	0.4	4.0
Risk taking	1.3	1.9	5.6	2.4	0.1	-0.1
Respiratory disease	1.2	2.8	3.9	-1.8	-1.2	-2.0
Number of treatments/medications taken	1.2	2.2	4.0	-0.8	-1.4	-2.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.7	1.9	0.7	0.7
Ever had hysterectomy (womb removed)	1.2	1.4	2.5	-1.0	0.8	-1.6
Leg fat-free mass (left)	1.2	6.2	13.3	2.3	0.4	3.6
Serious illness, injury or assault to yourself	1.2	1.4	2.2	1.5	0.5	-1.4
Alcohol usually taken with meals	1.2	1.9	3.3	1.8	1.6	-0.2
Breastfed as a baby	1.2	1.5	2.3	1.5	1.5	0.1
Medication: Amlodipine	1.2	1.7	4.4	-2.1	0.1	-0.8
Arm fat-free mass (right)	1.2	6.1	11.7	2.4	0.9	3.4
Emphysema/chronic bronchitis	1.2	1.3	2.8	-1.7	0.2	-1.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.2	1.0	-0.4	1.8
Illnesses of father: Heart disease	1.2	1.6	4.5	0.6	2.1	-0.0
Mood swings	1.2	2.2	2.9	1.1	-1.7	-1.5
Osteoporosis (self-reported)	1.2	1.5	2.2	1.1	1.5	-1.1
Neuroticism (2016)	1.1	1.5	1.8	1.0	-1.4	-1.3
Hand grip strength (left)	1.1	3.0	4.7	0.7	2.2	1.9
Leg predicted mass (left)	1.1	5.6	12.2	2.1	0.3	3.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.8	0.3	-1.6	2.2
Asthma	1.1	2.2	4.2	-0.9	-1.2	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.2	-0.8	-0.6	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.7	0.5	-0.5	-1.9
Medication: Blood pressure	1.1	1.9	4.8	-0.5	-0.8	-2.2
Leg fat-free mass (right)	1.1	5.7	12.0	2.2	0.6	3.5
Ovarian Cancer	1.0	1.3	1.7	1.0	1.2	1.3
Height	1.0	20.2	31.7	5.6	2.0	5.0
Allergy or Eczema	1.0	2.7	5.4	2.3	-0.2	1.7
Medication: Metformin	1.0	1.3	3.0	0.3	-1.7	-0.9
Maternal smoking around birth	1.0	1.4	2.1	-1.4	1.2	-0.9
Birth weight of first child	1.0	1.8	3.7	1.3	-0.3	1.9
Blood clot in the leg (DVT)	1.0	1.3	2.4	1.2	-1.5	0.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.6	-0.1	-0.4	-1.9
Qualifications: College or University degree	1.0	3.3	8.5	2.9	0.8	0.8
Leg pain on walking	1.0	1.2	1.9	1.1	-1.4	-0.8
Smoking status: Previous	1.0	1.5	3.0	1.7	1.2	0.2
Average weekly red wine intake	1.0	1.5	2.0	1.2	1.1	1.4
Friendships satisfaction	1.0	1.3	1.5	-1.1	-1.0	-1.2
Leg predicted mass (right)	1.0	5.6	11.7	2.2	0.6	3.4
Hearing aid user	1.0	1.1	1.7	-0.8	-1.3	-1.1
Alcohol drinker status: Never	1.0	1.2	2.1	-1.4	-0.9	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.0	1.0	-1.7	-0.2
Heart disease (siblings)	1.0	1.2	3.6	1.9	-0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.4	0.9	1.2	1.0
Relative age of first facial hair	0.9	1.8	2.6	1.1	-1.3	-1.6
Vitamin and mineral supplements	0.9	1.2	2.7	-0.4	1.6	0.9
Diabetes (father)	0.9	1.1	1.7	0.8	-1.0	-1.3
Townsend deprivation index at recruitment	0.9	1.3	2.3	0.2	-1.5	1.2
Medication: Atenolol	0.9	1.1	2.7	-0.5	0.5	-1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.3	3.4	-0.5	-1.9	-0.4
Medication: Simvastatin	0.9	1.3	3.0	1.7	-0.8	0.5
Weight	0.9	4.5	9.2	2.0	-0.6	3.0
Alcohol intake frequency.	0.9	2.1	3.6	-0.8	-1.5	-1.9
Had major operations	0.9	1.1	1.7	1.3	0.8	0.9
Age at last live birth	0.9	1.3	2.2	0.4	-1.5	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.4	1.9	0.0	1.5
Breast cancer (self-reported)	0.9	1.1	1.6	-0.4	-1.3	-1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	-0.4	-1.6	0.7
Average weekly champagne plus white wine intake	0.9	1.3	2.2	1.5	-1.3	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	1.8	0.7	0.9	1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	-0.2	-1.0	-1.5
Pain experienced in last month	0.9	1.5	3.6	-0.2	1.9	0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	2.0	-0.8	1.4	0.8
Diabetes (mother)	0.8	1.0	1.5	-1.2	0.1	1.2
Sitting height	0.8	5.8	9.0	2.9	0.3	3.0
Waist circumference	0.8	2.8	6.6	1.2	-0.8	2.6
Had menopause	0.8	1.0	2.4	0.6	1.5	-0.4
High blood pressure (siblings)	0.8	1.2	2.5	-0.7	0.8	-1.6
Medication for pain relief, constipation, heartburn	0.8	1.4	3.7	1.9	0.3	0.6
Chest pain or discomfort	0.8	1.1	1.5	-0.7	-1.2	-1.2
Osteoarthritis (self-reported)	0.8	1.1	2.7	1.6	0.6	0.3
Medication: Gliclazide	0.8	0.9	2.3	1.5	0.2	0.6
Mother’s age at death	0.8	1.0	2.8	0.0	1.7	-0.5
Irritability	0.8	1.3	1.8	0.9	-1.3	-1.2
Fractured/broken bones in last 5 years	0.8	1.0	1.6	-1.3	0.8	-0.8
Diastolic blood pressure, automated reading	0.8	2.4	4.0	-2.0	-1.8	-0.1
Alcohol drinker status: Previous	0.8	0.9	2.2	0.6	-1.5	-0.5
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	1.3	0.2	0.8
Irritable Bowel Disease (IBD)	0.7	1.6	2.9	-1.3	0.5	-1.7
Mean Putamen Volume	0.7	0.8	1.1	-1.1	-0.9	-0.6
HDL Cholesterol	0.7	1.2	3.1	0.2	-0.6	1.8
Systolic Blood Pressure	0.7	3.7	8.6	-1.6	-0.3	-2.9
Cardiovascular Disease	0.7	2.2	3.7	-0.8	-1.9	-1.5
Medication for hormone replacement therapy	0.7	0.7	1.7	-0.6	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.8	-0.5	-1.7	1.4
Supplements: Glucosamine	0.7	0.9	1.2	1.1	0.8	-0.9
Number of incorrect matches in round	0.7	1.2	2.7	-0.4	1.6	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.2	-0.2	-1.5	-0.7
Loud music exposure frequency	0.7	0.8	1.4	-1.0	1.2	-0.1
Forced vital capacity (FVC), Best measure	0.7	2.7	6.6	2.6	1.0	0.8
Exposure to tobacco smoke outside home	0.7	1.0	2.9	1.7	0.1	0.0
Worry too long after embarrassment	0.7	1.3	2.0	-0.6	-1.4	-1.2
Health satisfaction	0.7	0.9	1.9	1.4	0.5	0.6
Migraine (self-reported)	0.7	0.9	1.5	-1.0	-1.2	-0.1
Medication: Ibuprofen	0.7	0.9	1.7	-1.3	0.3	0.9
Commuting to job workplace: Walk	0.7	0.7	1.4	1.2	0.1	0.8
Cholesterol lowering medication	0.7	1.1	2.4	0.8	-1.6	0.4
Bipolar Disorder (2011)	0.6	0.6	1.6	0.1	-0.4	-1.2
Waist Hip Ratio (WHR)	0.6	2.8	7.0	0.3	-1.1	2.6
Hearing difficulty/problems: Yes	0.6	0.9	1.3	1.2	0.7	0.9
Pack years adult smoking proportion	0.6	1.0	1.5	-1.2	-0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.4	-0.6	0.5	-1.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.3	1.8	0.1	0.7
Prospective memory result	0.6	0.7	1.3	-0.3	-0.8	-1.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.6	1.6	0.3	0.3
Neck or shoulder pain in last month	0.6	0.9	1.6	1.3	-0.7	0.8
Mean time to correctly identify matches	0.6	1.1	2.9	1.7	0.7	0.0
Long-standing illness, disability or infirmity	0.6	1.0	1.7	1.3	-0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.8	0.8	-0.9	-0.7
Qualifications: nursing, teaching	0.6	1.0	2.8	0.3	1.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.7	-0.4	-0.0	-1.6
Back pain experienced in last month	0.6	0.8	2.0	0.7	-0.4	-1.4
Ever smoked	0.6	1.1	1.6	1.2	0.5	1.3
Average weekly beer plus cider intake	0.6	0.8	2.5	-1.6	-0.1	-0.2
Bipolar Disorder (2018)	0.5	0.8	2.0	1.4	-0.3	-0.5
Primary Biliary Cirrhosis	0.5	0.7	1.2	0.2	-1.1	-0.9
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.9	-0.7	-1.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.2	-0.4	-1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.5	-1.2	0.7	0.3
High blood pressure	0.5	1.3	2.8	0.1	-1.1	-1.7
Past tobacco smoking	0.5	0.9	2.0	-1.4	-0.7	-0.3
Had other major operations	0.5	0.6	1.3	-0.1	-0.6	-1.1
Forced vital capacity (FVC)	0.5	1.7	3.6	1.9	1.2	0.4
Medication: Ramipril	0.5	0.7	0.9	-0.9	-0.6	0.9
Happiness	0.5	0.6	1.0	0.2	-1.0	-0.8
Mouth/teeth dental problems: Dentures	0.5	0.9	2.0	1.4	-0.6	-0.7
Tense / ‘highly strung’	0.5	0.8	1.5	0.7	-0.6	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.2	0.1	0.2	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.1	-0.8	1.0	0.0
Illnesses of siblings: Diabetes	0.5	0.6	1.1	0.5	-1.1	0.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.5	-0.3	-0.3	1.2
Medication: Blood pressure	0.5	0.9	2.2	0.5	-0.4	-1.5
High cholesterol (Self-reported)	0.5	0.9	1.2	0.6	-1.1	1.0
Myopia	0.5	0.8	2.2	1.5	-0.3	-0.1
Schizophrenia (2018)	0.4	0.9	1.6	-1.0	1.3	-0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	1.2	-0.2	-0.1
Age at First Birth	0.4	0.6	1.0	-0.3	1.0	0.7
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	-1.2	-0.5	0.5
Fasting Glucose	0.4	0.5	1.4	-1.2	-0.1	0.1
Chronotype (morning person)	0.4	0.9	2.6	-1.6	0.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.1	0.5	1.1	0.2
Angina	0.4	0.5	0.7	0.8	-0.7	-0.5
Relative age voice broke	0.4	0.7	1.1	0.1	-1.1	-0.9
Multivitamins +/- minerals	0.4	0.5	0.8	-0.3	-0.8	-0.9
High blood pressure (mother)	0.4	0.5	0.9	0.6	0.9	-0.5
Nervous feelings	0.4	0.7	1.4	-0.2	-0.9	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	0.6	-1.0	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-0.5	-0.3	-1.1
Fluid intelligence score	0.4	0.9	1.9	0.8	1.4	0.2
Falls in the last year	0.4	0.6	1.1	1.0	0.3	0.7
Medication: Cholesterol lowering	0.4	0.6	1.4	1.2	0.3	0.4
Arm fat mass (right)	0.4	1.6	3.3	0.8	-0.9	1.8
Medication: Omeprazole	0.4	0.5	0.7	-0.8	-0.3	-0.9
Whole body fat mass	0.4	1.5	2.6	0.8	-1.1	1.6
Leg fat mass (right)	0.4	1.5	2.4	1.1	-1.0	1.5
Comparative height size at age 10	0.4	2.4	3.6	1.9	0.5	1.8
Number of full sisters	0.4	0.5	1.1	0.1	1.0	0.6
Overall health rating	0.4	0.9	1.5	-0.7	-1.2	-0.9
Hypertension (Self-reported)	0.4	1.0	2.2	0.4	-0.8	-1.5
Mineral and other dietary supplements	0.4	0.5	1.0	-1.0	-0.5	0.5
Medication: Aspirin	0.4	0.6	0.7	0.6	0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.7	0.9	1.3	-0.2
Miserableness	0.4	0.6	1.6	0.4	-1.3	0.3
Commuting to job workplace: Public transport	0.4	0.5	0.6	0.7	-0.7	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.6	-0.1	0.9	1.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.5	-0.0	-1.1
Pack years of smoking	0.4	0.5	0.8	-0.9	-0.3	-0.9
Impedance of whole body	0.4	2.0	4.3	-0.8	-1.0	-2.1
Leg fat mass (left)	0.4	1.4	2.4	1.0	-0.9	1.6
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.2	-0.9	-0.3
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.9	0.0	-0.6
HbA1C	0.3	0.3	0.8	-0.1	-0.9	0.4
Ulcerative Colitis	0.3	0.5	1.2	0.4	-1.1	-0.1
Blood Eosinophil Count	0.3	2.6	5.4	-1.1	-2.3	-1.1
Lung FVC	0.3	1.6	2.5	-0.2	1.5	-1.6
Tanning	0.3	3.7	11.0	-3.3	-0.1	0.3
Systolic blood pressure, automated reading	0.3	0.8	1.7	-1.3	0.8	-0.3
Average weekly fortified wine intake	0.3	0.4	1.1	1.1	0.0	-0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.8	-0.0	0.5
Trunk fat mass	0.3	1.4	2.0	0.9	-1.2	1.4
Heart attack	0.3	0.4	1.1	0.3	-0.1	-1.1
Hip circumference	0.3	1.1	1.8	1.3	0.1	1.3
Number of live births	0.3	0.5	0.7	-0.7	-0.5	0.8
Medication: Lansoprazole	0.3	0.3	0.6	-0.8	-0.6	-0.3
Impedance of arm (left)	0.3	1.4	3.2	-0.7	-0.6	-1.8
Length of working week for main job	0.3	0.3	0.8	0.3	-0.9	-0.3
Exposure to tobacco smoke at home	0.3	0.4	1.0	1.0	0.4	0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.9	1.0	-0.3	-0.0
Leg fat percentage (right)	0.3	1.0	2.9	-0.1	-1.7	0.3
Comparative body size at age 10	0.3	0.8	1.4	-1.2	-0.7	-0.8
Number of children fathered	0.3	0.3	0.8	-0.9	-0.1	-0.3
Angina (self-reported)	0.3	0.3	0.6	0.8	-0.4	-0.5
Medication: Allopurinol	0.3	0.4	0.8	0.9	-0.1	0.7
Suffer from ‘nerves’	0.3	0.5	1.1	-0.5	-0.2	-1.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.6	-0.7	-0.1
Medication: Aspirin	0.3	0.4	0.5	0.5	0.7	-0.6
Medication for cholesterol	0.3	0.5	0.8	0.3	0.8	0.9
Arm fat mass (left)	0.3	1.3	2.3	0.5	-1.1	1.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	1.1	0.5	-0.2
Number of operations (self-reported)	0.3	0.4	0.7	0.8	0.7	-0.3
Age started oral contraceptive pill	0.3	0.4	0.5	-0.4	0.7	0.7
Ever depressed for a whole week	0.3	0.4	0.8	0.9	-0.3	-0.4
Reaction Time	0.2	0.3	0.5	0.7	0.3	-0.6
Schizophrenia (2014)	0.2	0.5	0.9	-0.7	0.5	-1.0
BMI	0.2	1.1	2.3	-1.0	-1.5	-0.4
Smoking Status	0.2	0.4	1.2	0.3	0.0	1.1
Impedance of leg (right)	0.2	1.2	2.9	-0.3	-0.7	-1.7
Trunk fat percentage	0.2	0.8	1.9	0.1	-1.4	0.6
Hand grip strength (right)	0.2	0.6	1.6	0.3	0.5	1.3
Age when periods started (menarche)	0.2	0.5	1.3	0.5	-1.1	-0.4
Body mass index (BMI)	0.2	0.8	1.4	0.1	-1.0	1.2
Impedance of leg (left)	0.2	1.2	3.1	-0.5	-0.3	-1.8
Illnesses of siblings	0.2	0.3	0.7	0.5	-0.3	0.8
Arm fat percentage (right)	0.2	0.9	2.0	0.0	-1.4	0.7
Father’s age at death	0.2	0.2	0.5	0.3	0.7	0.2
Lung cancer (father)	0.2	0.3	0.5	-0.7	0.1	-0.6
Pulse wave Arterial Stiffness index	0.2	0.3	0.7	-0.0	0.8	-0.4
Headache pain in last month	0.2	0.3	0.6	0.1	-0.8	0.6
Birth weight	0.2	0.5	1.5	-0.0	-1.2	-0.3
Body fat percentage	0.2	0.8	1.9	-0.0	-1.4	0.6
Number of full brothers	0.2	0.3	0.6	-0.3	0.8	0.5
Pulse wave peak to peak time	0.2	0.3	0.4	0.3	-0.6	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.6	-0.4	-0.4
Family relationship satisfaction	0.2	0.2	0.5	0.7	-0.3	0.0
Arm fat percentage (left)	0.2	0.7	2.0	-0.2	-1.4	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.3	-0.3	0.8
Financial situation satisfaction	0.2	0.2	0.4	-0.7	0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.6	0.4	0.3
Leg fat percentage (left)	0.2	0.6	1.6	-0.2	-1.3	0.5
Bipolar Disorder or Schizophrenia	0.1	0.4	0.7	0.1	0.8	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.3	0.7	0.0
Ulcerative Colitis (UC)	0.1	0.3	0.6	-0.3	0.4	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.2	0.4	0.4	0.4
Blood Red Count	0.1	0.8	1.2	1.1	-1.1	0.3
Hair Pigment	0.1	1.9	4.2	-1.2	2.0	0.4
Allergy	0.1	0.3	0.3	-0.6	0.5	0.4
Diabetes (self-reported)	0.1	0.2	0.3	-0.2	-0.5	0.4
Impedance of arm (right)	0.1	0.5	1.3	-0.2	-0.4	-1.2
Time employed in main current job	0.1	0.2	0.4	0.3	-0.6	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.3	-0.5	0.3
Noisy workplace	0.1	0.2	0.3	0.5	0.2	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.9	0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.1	0.2	0.5
Pulse wave reflection index	0.1	0.2	0.3	0.3	0.3	0.6
Glaucoma (self-reported)	0.1	0.1	0.1	-0.4	-0.4	-0.2
Gout (self-reported)	0.1	0.1	0.3	0.4	-0.5	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.3	0.5	0.3
Age at first live birth	0.1	0.2	0.3	-0.3	-0.5	-0.6
Knee pain experienced in last month	0.1	0.2	0.2	0.4	-0.5	0.4
Ever had bowel cancer screening	0.1	0.1	0.3	0.1	0.2	0.6
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.7	0.0	-0.3
Medication: Atorvastatin	0.1	0.1	0.1	-0.4	-0.2	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	0.6	-0.4	-0.2	0.8
Heel T-Score	0.0	0.3	0.3	-0.4	0.6	0.5
Wears glasses or contact lenses	0.0	0.1	0.1	0.2	0.1	-0.3
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.1	0.0	-0.2

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