Best TWAS P=1.55e-40 · Best GWAS P=2.41e-50 conditioned to 2.02e-34
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PDXDC1 | 0.17 | 0.07 | enet | 17 | 0.10 | 1.3e-11 | -4.5 | -5.8 | 6.3e-09 | 0.04 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | RRN3 | 0.11 | 0.08 | enet | 12 | 0.12 | 3.3e-14 | 6.4 | 5.5 | 4.9e-08 | -0.13 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Subcutaneous | NTAN1 | 0.05 | 0.03 | lasso | 2 | 0.04 | 6.7e-04 | -9.5 | 10.1 | 4.6e-24 | -0.12 | 0.01 | 0.97 | FALSE |
4 | GTEx | Adipose Visceral Omentum | PKD1P6 | 0.26 | 0.15 | lasso | 4 | 0.14 | 1.6e-07 | 6.3 | 5.7 | 9.3e-09 | -0.08 | 0.96 | 0.00 | FALSE |
5 | GTEx | Artery Aorta | RP11-958N24.1 | 0.09 | 0.00 | enet | 5 | 0.02 | 1.7e-02 | 1.8 | 5.7 | 1.1e-08 | -0.14 | 0.09 | 0.04 | FALSE |
6 | GTEx | Artery Coronary | NPIPA5 | 0.30 | 0.03 | enet | 13 | 0.07 | 3.1e-03 | -6.6 | 6.8 | 1.2e-11 | -0.02 | 0.02 | 0.79 | FALSE |
7 | GTEx | Artery Tibial | RRN3 | 0.11 | 0.06 | lasso | 2 | 0.07 | 2.0e-06 | 8.2 | 8.0 | 1.6e-15 | -0.14 | 0.94 | 0.03 | FALSE |
8 | GTEx | Artery Tibial | NPIPA1 | 0.15 | 0.05 | lasso | 3 | 0.04 | 2.0e-04 | 6.4 | 5.8 | 5.6e-09 | -0.08 | 0.20 | 0.03 | FALSE |
9 | GTEx | Artery Tibial | PKD1P6 | 0.11 | 0.05 | lasso | 5 | 0.03 | 2.4e-03 | 6.3 | 6.2 | 4.4e-10 | -0.09 | 0.18 | 0.03 | FALSE |
10 | GTEx | Brain Caudate basal ganglia | NPIPA2 | 0.23 | 0.08 | lasso | 7 | 0.13 | 1.3e-04 | 1.3 | 5.3 | 1.2e-07 | -0.07 | 0.04 | 0.12 | FALSE |
11 | GTEx | Brain Hippocampus | NPIPA3 | 0.26 | 0.00 | lasso | 12 | 0.01 | 1.5e-01 | 3.0 | 5.6 | 2.0e-08 | 0.12 | 0.04 | 0.06 | FALSE |
12 | GTEx | Breast Mammary Tissue | RP11-958N24.1 | 0.08 | 0.04 | enet | 18 | 0.04 | 5.1e-03 | 6.4 | 5.9 | 3.2e-09 | -0.08 | 0.04 | 0.11 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | RRN3 | 0.36 | 0.14 | lasso | 5 | 0.20 | 4.5e-07 | 8.2 | 8.8 | 1.5e-18 | -0.14 | 0.20 | 0.76 | FALSE |
14 | GTEx | Cells EBV-transformed lymphocytes | PDXDC1 | 0.25 | 0.03 | enet | 20 | 0.05 | 1.1e-02 | -8.5 | 5.9 | 3.5e-09 | 0.00 | 0.02 | 0.74 | FALSE |
15 | GTEx | Cells EBV-transformed lymphocytes | NPIPA1 | 0.26 | 0.07 | lasso | 3 | 0.10 | 3.7e-04 | 6.2 | 6.8 | 8.1e-12 | -0.10 | 0.06 | 0.16 | FALSE |
16 | GTEx | Cells EBV-transformed lymphocytes | RP11-958N24.1 | 0.22 | 0.02 | lasso | 5 | 0.06 | 4.8e-03 | -3.7 | 7.7 | 1.3e-14 | -0.14 | 0.02 | 0.34 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | RRN3 | 0.10 | 0.12 | enet | 13 | 0.13 | 6.3e-10 | 8.2 | 8.3 | 9.9e-17 | -0.15 | 0.72 | 0.28 | FALSE |
18 | GTEx | Colon Transverse | RRN3 | 0.13 | 0.00 | lasso | 5 | 0.00 | 1.9e-01 | 8.0 | -6.1 | 1.1e-09 | 0.11 | 0.02 | 0.32 | FALSE |
19 | GTEx | Esophagus Gastroesophageal Junction | NPIPA1 | 0.19 | 0.15 | lasso | 2 | 0.10 | 1.4e-04 | 6.3 | 6.4 | 1.9e-10 | -0.09 | 0.41 | 0.03 | FALSE |
20 | GTEx | Esophagus Mucosa | RRN3 | 0.13 | 0.13 | lasso | 4 | 0.13 | 3.2e-09 | 8.0 | 7.3 | 2.6e-13 | -0.14 | 0.92 | 0.08 | FALSE |
21 | GTEx | Heart Atrial Appendage | NOMO1 | 0.19 | 0.12 | lasso | 6 | 0.10 | 3.7e-05 | 8.0 | 8.1 | 4.4e-16 | -0.15 | 0.30 | 0.03 | FALSE |
22 | GTEx | Heart Atrial Appendage | NTAN1 | 0.10 | 0.09 | lasso | 1 | 0.07 | 3.7e-04 | 8.0 | 8.0 | 1.3e-15 | -0.14 | 0.04 | 0.46 | FALSE |
23 | GTEx | Heart Left Ventricle | RRN3 | 0.24 | 0.12 | lasso | 7 | 0.17 | 2.2e-09 | 8.0 | -7.7 | 1.4e-14 | 0.11 | 0.56 | 0.35 | FALSE |
24 | GTEx | Heart Left Ventricle | NTAN1 | 0.09 | 0.04 | lasso | 3 | 0.02 | 2.0e-02 | 8.2 | 8.5 | 2.3e-17 | -0.14 | 0.02 | 0.71 | FALSE |
25 | GTEx | Muscle Skeletal | RRN3 | 0.18 | 0.03 | enet | 17 | 0.11 | 5.7e-11 | 2.2 | -6.8 | 1.5e-11 | 0.09 | 0.18 | 0.68 | FALSE |
26 | GTEx | Muscle Skeletal | NTAN1 | 0.12 | 0.07 | lasso | 6 | 0.09 | 1.4e-09 | 8.0 | 7.0 | 2.4e-12 | -0.13 | 0.96 | 0.03 | FALSE |
27 | GTEx | Nerve Tibial | NTAN1 | 0.07 | 0.00 | enet | 14 | 0.00 | 1.7e-01 | 8.2 | 5.7 | 1.6e-08 | -0.05 | 0.02 | 0.20 | FALSE |
28 | GTEx | Nerve Tibial | RP11-958N24.1 | 0.11 | 0.06 | lasso | 1 | 0.04 | 7.6e-04 | 6.4 | 6.4 | 2.0e-10 | -0.09 | 0.46 | 0.04 | FALSE |
29 | GTEx | Skin Sun Exposed Lower leg | RRN3 | 0.10 | 0.12 | lasso | 1 | 0.11 | 4.5e-09 | 8.2 | 8.2 | 1.8e-16 | -0.14 | 0.93 | 0.06 | FALSE |
30 | GTEx | Skin Sun Exposed Lower leg | PKD1P6 | 0.11 | 0.07 | lasso | 3 | 0.06 | 6.4e-06 | 6.4 | 6.7 | 2.8e-11 | -0.09 | 0.75 | 0.01 | FALSE |
31 | GTEx | Small Intestine Terminal Ileum | RP11-680G24.4 | 0.27 | 0.05 | lasso | 5 | 0.05 | 2.9e-02 | -7.3 | 7.0 | 1.8e-12 | -0.03 | 0.02 | 0.27 | FALSE |
32 | GTEx | Testis | RRN3 | 0.10 | 0.10 | lasso | 2 | 0.07 | 3.9e-04 | 8.2 | 8.2 | 1.8e-16 | -0.14 | 0.11 | 0.14 | FALSE |
33 | GTEx | Testis | RP11-958N24.1 | 0.09 | 0.10 | lasso | 2 | 0.07 | 6.1e-04 | 6.2 | 6.3 | 2.5e-10 | -0.08 | 0.10 | 0.08 | FALSE |
34 | GTEx | Thyroid | RP11-65J21.3 | 0.35 | 0.32 | lasso | 2 | 0.31 | 2.6e-24 | -13.3 | -13.3 | 1.6e-40 | -0.54 | 1.00 | 0.00 | TRUE |
35 | METSIM | Adipose | NOMO1 | 0.10 | 0.07 | lasso | 4 | 0.06 | 3.0e-09 | 6.4 | 6.4 | 1.8e-10 | -0.09 | 1.00 | 0.00 | FALSE |
36 | METSIM | Adipose | NTAN1 | 0.07 | 0.06 | enet | 12 | 0.06 | 1.7e-09 | 8.2 | 7.9 | 2.7e-15 | -0.12 | 1.00 | 0.00 | FALSE |
37 | METSIM | Adipose | PDXDC1 | 0.14 | 0.04 | bslmm | 148 | 0.06 | 3.0e-09 | 6.4 | -5.5 | 3.0e-08 | 0.12 | 0.79 | 0.04 | FALSE |
38 | METSIM | Adipose | RP11-1186N24.5 | 0.18 | 0.10 | enet | 24 | 0.13 | 4.6e-19 | 6.3 | 5.3 | 1.3e-07 | -0.07 | 1.00 | 0.00 | FALSE |
39 | NTR | Blood | NTAN1 | 0.01 | 0.00 | bslmm | 110 | 0.00 | 4.2e-02 | 8.2 | 8.2 | 2.5e-16 | -0.09 | 0.02 | 0.03 | FALSE |
40 | NTR | Blood | PDXDC1 | 0.12 | 0.12 | enet | 26 | 0.15 | 1.3e-46 | -9.6 | 11.2 | 6.8e-29 | -0.14 | 0.01 | 0.99 | TRUE |
41 | ROSMAP | Brain Pre-frontal Cortex | NTAN1 | 0.12 | 0.10 | lasso | 3 | 0.11 | 1.4e-13 | 8.0 | 8.8 | 2.0e-18 | -0.14 | 1.00 | 0.00 | FALSE |
42 | ROSMAP | Brain Pre-frontal Cortex | RP11-958N24.1 | 0.07 | 0.01 | enet | 7 | 0.02 | 1.9e-03 | 8.0 | 6.5 | 7.1e-11 | -0.12 | 0.44 | 0.08 | FALSE |
43 | ROSMAP | Brain Pre-frontal Cortex | NPIPP1 | 0.27 | 0.11 | enet | 15 | 0.14 | 2.2e-17 | 6.3 | 5.8 | 6.3e-09 | -0.09 | 1.00 | 0.00 | FALSE |
44 | ROSMAP | Brain Pre-frontal Cortex | PKD1P6 | 0.04 | 0.01 | enet | 10 | 0.01 | 4.3e-02 | -4.5 | -6.0 | 1.6e-09 | 0.07 | 0.03 | 0.10 | FALSE |
45 | ROSMAP | Brain Pre-frontal Cortex | NPIPA2 | 0.48 | 0.26 | bslmm | 145 | 0.47 | 2.1e-68 | 6.4 | -8.8 | 1.9e-18 | 0.06 | 1.00 | 0.00 | FALSE |
46 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RRN3 | 0.09 | 0.07 | lasso | 2 | 0.05 | 3.3e-05 | 6.4 | 7.3 | 2.4e-13 | -0.12 | 0.80 | 0.03 | FALSE |
47 | The Cancer Genome Atlas | Colon Adenocarcinoma | RRN3 | 0.07 | 0.00 | blup | 31 | 0.02 | 4.0e-02 | 6.4 | 5.2 | 1.6e-07 | -0.13 | 0.01 | 0.04 | FALSE |
48 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RRN3 | 0.13 | 0.05 | enet | 17 | 0.10 | 3.5e-11 | 8.0 | 7.3 | 2.7e-13 | -0.12 | 1.00 | 0.00 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDXDC1 | 0.03 | 0.00 | enet | 17 | 0.02 | 1.1e-03 | -9.5 | -5.2 | 1.7e-07 | 0.05 | 0.01 | 0.70 | FALSE |
50 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RRN3 | 0.17 | 0.07 | lasso | 2 | 0.07 | 4.9e-04 | 6.3 | -5.8 | 5.2e-09 | 0.08 | 0.07 | 0.08 | FALSE |
51 | The Cancer Genome Atlas | Lung Adenocarcinoma | RRN3 | 0.06 | 0.04 | blup | 31 | 0.05 | 3.1e-06 | 8.2 | 6.5 | 8.2e-11 | -0.12 | 0.89 | 0.01 | FALSE |
52 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RRN3 | 0.03 | 0.00 | blup | 31 | 0.02 | 4.3e-03 | 6.4 | 7.5 | 7.3e-14 | -0.13 | 0.04 | 0.11 | FALSE |
53 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABCC6 | 0.16 | 0.04 | enet | 16 | 0.16 | 1.8e-16 | 3.0 | 5.4 | 7.1e-08 | -0.07 | 0.02 | 0.09 | TRUE |
54 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCC1 | 0.07 | 0.07 | lasso | 5 | 0.06 | 1.5e-06 | 4.6 | 5.5 | 3.4e-08 | -0.01 | 0.03 | 0.94 | TRUE |
55 | The Cancer Genome Atlas | Thyroid Carcinoma | PDXDC1 | 0.25 | 0.12 | enet | 12 | 0.14 | 1.3e-13 | -9.5 | -6.1 | 9.3e-10 | 0.01 | 0.02 | 0.98 | FALSE |
56 | The Cancer Genome Atlas | Thyroid Carcinoma | RRN3 | 0.09 | 0.06 | lasso | 2 | 0.07 | 1.6e-07 | 8.0 | 8.0 | 1.2e-15 | -0.14 | 0.96 | 0.02 | FALSE |
57 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ABCC1 | 0.32 | -0.01 | blup | 228 | 0.01 | 1.4e-01 | -1.2 | 6.2 | 7.2e-10 | -0.06 | 0.02 | 0.09 | TRUE |