Best TWAS P=5.29e-26 · Best GWAS P=6.52e-24 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | WDR35 | 0.11 | 0.06 | lasso | 8 | 0.08 | 4.6e-07 | 5.8 | -5.2 | 2.4e-07 | 0.22 | 0.83 | 0.05 | TRUE |
2 | GTEx | Adrenal Gland | LAPTM4A | 0.47 | 0.36 | lasso | 5 | 0.36 | 1.3e-13 | -7.1 | 7.9 | 2.3e-15 | -0.17 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Aorta | WDR35 | 0.25 | 0.00 | enet | 50 | 0.01 | 9.3e-02 | 4.1 | -7.0 | 2.4e-12 | -0.05 | 0.06 | 0.10 | TRUE |
4 | GTEx | Brain Hippocampus | TTC32 | 0.35 | 0.28 | lasso | 10 | 0.29 | 1.3e-07 | -8.1 | -9.1 | 6.3e-20 | 0.53 | 0.18 | 0.59 | TRUE |
5 | GTEx | Esophagus Muscularis | MATN3 | 0.26 | 0.14 | enet | 39 | 0.20 | 1.5e-12 | 3.1 | 5.3 | 1.1e-07 | -0.22 | 1.00 | 0.00 | TRUE |
6 | GTEx | Nerve Tibial | WDR35 | 0.22 | 0.05 | enet | 26 | 0.15 | 7.6e-11 | 4.1 | -8.3 | 1.3e-16 | 0.20 | 0.07 | 0.91 | FALSE |
7 | GTEx | Pancreas | LAPTM4A | 0.33 | 0.16 | lasso | 10 | 0.12 | 7.9e-06 | -7.1 | 7.8 | 8.1e-15 | -0.16 | 0.55 | 0.11 | TRUE |
8 | GTEx | Thyroid | WDR35 | 0.13 | 0.01 | lasso | 6 | 0.04 | 4.9e-04 | 6.5 | -10.5 | 5.3e-26 | 0.24 | 0.40 | 0.38 | TRUE |
9 | ROSMAP | Brain Pre-frontal Cortex | HS1BP3 | 0.10 | 0.01 | blup | 535 | 0.03 | 4.6e-05 | 4.9 | -6.0 | 1.7e-09 | 0.09 | 0.81 | 0.00 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | GDF7 | 0.07 | 0.02 | lasso | 4 | 0.07 | 4.4e-09 | 5.0 | -5.2 | 1.5e-07 | 0.07 | 0.92 | 0.00 | TRUE |
11 | The Cancer Genome Atlas | Colon Adenocarcinoma | SDC1 | 0.10 | 0.00 | blup | 59 | 0.04 | 1.6e-03 | -1.1 | -5.7 | 1.0e-08 | 0.38 | 0.31 | 0.13 | TRUE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MATN3 | 0.15 | 0.11 | blup | 54 | 0.11 | 1.9e-05 | -8.1 | -8.3 | 7.8e-17 | 0.23 | 0.02 | 0.95 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR35 | 0.09 | 0.08 | lasso | 3 | 0.07 | 1.1e-07 | -9.7 | -9.7 | 2.9e-22 | 0.19 | 0.00 | 1.00 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | MATN3 | 0.05 | 0.00 | blup | 53 | 0.02 | 6.5e-03 | -9.0 | 8.0 | 1.4e-15 | -0.26 | 0.01 | 0.48 | FALSE |