Hub : Genes

HS1BP3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0800 0.0270 1.3e-03 0.026 0.012 0.005 0.017 0.019 3.6e-04 1.0e-02 6.9e-02 3.3e-03 1.7e-03
2 GTEx Artery Tibial 0.1226 0.0442 5.7e-03 0.061 NA 0.076 NA 0.087 1.5e-05 NA 1.5e-06 NA 2.4e-07
3 GTEx Esophagus Mucosa 0.1650 0.0580 5.4e-03 -0.004 NA -0.002 NA -0.003 6.9e-01 NA 4.8e-01 NA 5.7e-01
4 METSIM Adipose 0.0837 0.0276 1.6e-04 -0.002 0.021 0.017 0.022 0.000 7.4e-01 3.6e-04 1.3e-03 2.7e-04 2.8e-01
5 ROSMAP Brain Pre-frontal Cortex 0.1011 0.0298 9.7e-05 0.006 0.032 0.013 0.030 0.013 4.6e-02 4.6e-05 7.1e-03 7.9e-05 7.6e-03
6 YFS Blood 0.0256 0.0098 1.8e-03 0.004 0.009 0.003 0.008 0.003 1.2e-02 3.7e-04 3.2e-02 1.2e-03 2.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.9 1.4 3.3 1.3 -1.6 -0.3 0.5 -1.8 0.6
Bipolar Disorder or Schizophrenia 0.2 0.4 1.2 -0.4 -1.1 -0.3 0.5 1.0 -0.1
Depressed Affect (Nagel 2018) 1.2 2.5 6.3 0.7 -2.1 0.9 -0.9 2.5 -1.3
Depression (Nagel 2018) 0.5 0.8 2.5 1.6 -0.0 0.8 0.6 0.9 -0.5
Intelligence (Savage-Jansen 2018) 0.5 1.4 3.7 0.8 0.1 -1.3 -1.9 -0.1 1.6
Neuroticism (Nagel 2018) 0.4 1.1 4.4 -0.1 -0.8 0.9 0.2 2.1 -0.7
Schizophrenia (2018) 0.8 1.7 7.4 -1.6 -0.1 -0.3 0.3 2.7 -0.5
Schizophrenia vs Biploar Disorder 0.6 0.8 1.9 -0.2 1.0 0.9 -0.9 1.4 -0.3
Worry (Nagel 2018) 0.2 0.4 1.5 -0.5 0.1 0.6 -0.4 1.2 -0.1
Alzheimer’s Disease (in mother) 2.1 2.5 6.0 1.0 -1.8 -2.5 -1.5 -0.6 -1.4
Alzheimer’s Disease (in father) 0.4 0.5 1.2 0.7 0.9 0.5 -0.4 -0.3 1.1
Alzheimer’s Disease (including proxy) 0.4 0.5 1.9 0.9 -0.4 -1.4 -0.4 -0.4 0.0
Crohns Disease (2017) 0.4 0.8 1.3 0.3 -1.1 -1.1 -0.5 -0.8 -1.2
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 0.6 -0.9 -1.0 -1.9 -0.7 -0.9
Ulcerative Colitis (UC) 0.7 1.4 5.6 1.0 -0.3 -0.8 -2.4 0.0 -0.9
Major Depression (MDD) 0.8 1.0 2.8 0.0 0.0 1.7 1.4 0.8 0.9
Reaction Time 1.2 2.2 9.3 -1.0 1.6 0.4 -0.4 3.0 -0.2
Verbal and Numeric Reasoning (VNR) 0.4 1.0 4.3 0.2 0.5 0.1 -0.7 -0.7 2.1
Breast Cancer 0.3 0.8 2.2 0.6 1.5 0.9 0.8 -0.5 0.4
Ovarian Cancer 0.6 0.8 1.6 -1.2 -0.6 -0.6 -1.0 1.1 -0.5
Prostate Cancer 1.6 2.3 5.1 1.4 -2.3 2.1 -0.2 -0.5 -1.3
Age at First Birth 0.2 0.4 0.7 0.8 -0.6 -0.1 -0.7 -0.7 -0.2
Bipolar Disorder (2011) 1.8 1.7 6.2 2.5 -1.9 -0.5 -0.5 -0.2 0.6
Body Mass Index (BMI) (2010) 0.3 0.4 1.2 -0.6 -1.1 0.4 0.6 -0.2 0.1
Coronary Artery Disease (CAD) 0.4 0.4 1.0 0.9 -0.1 0.2 0.8 -0.3 1.0
Crohns Disease (2012) 0.5 0.8 1.8 0.3 -0.3 -1.3 0.2 -1.3 -1.1
Mean Putamen Volume 0.3 0.3 0.7 -0.4 -0.9 -0.1 -0.7 0.7 -0.4
Fasting Glucose 0.7 0.9 3.0 -1.1 0.2 1.7 0.9 0.4 0.5
HbA1C 0.5 0.6 1.2 0.8 -1.1 -0.5 0.2 -1.1 -0.3
HDL Cholesterol 6.0 10.1 29.4 1.0 -1.5 -2.4 -4.7 0.4 -5.4
LDL Cholesterol 6.7 10.6 44.0 1.7 2.7 -1.7 -0.9 -2.4 6.6
Lupus 0.3 0.5 1.6 -0.0 -0.3 -1.3 0.4 0.9 0.4
Neuroticism (2016) 0.8 1.1 3.5 -0.1 0.7 1.1 0.9 1.9 -0.9
Primary Biliary Cirrhosis 1.9 2.7 8.1 0.7 -1.3 -2.8 -1.1 -0.8 -2.0
Rheumatoid Arthritis 0.4 0.6 2.8 0.7 -1.7 -0.3 -0.3 0.2 0.3
Schizophrenia (2014) 0.6 1.2 4.7 -1.2 -0.8 -0.5 0.0 2.2 -0.6
Triglycerides 7.3 12.0 28.3 -0.2 2.3 3.1 5.3 0.4 5.3
Type 2 Diabetes (T2D) (2012) 1.2 1.4 4.5 -1.4 -0.7 -0.2 -0.1 1.2 -2.1
Ulcerative Colitis 0.1 0.1 0.3 -0.4 0.4 -0.2 -0.2 0.6 0.1
Blood Eosinophil Count 0.1 0.5 1.5 0.4 -1.0 -1.2 0.1 -0.4 0.6
Blood Platelet Count 0.3 3.1 6.1 1.0 1.1 -1.6 -2.5 1.2 -2.4
Blood Red Count 0.5 4.6 16.7 0.8 0.6 -1.8 -2.0 1.6 -4.1
Blood White Count 0.2 1.2 2.6 1.0 0.3 -0.8 -0.4 1.6 -1.6
Heel T-Score 0.3 2.5 4.8 0.5 -0.2 -2.2 -1.6 1.6 -2.2
BMI 0.2 1.3 4.8 -0.3 -1.1 -2.2 -0.0 1.1 -0.6
Height 0.6 10.9 36.2 4.2 -1.6 0.9 -1.6 -6.0 -2.4
Waist Hip Ratio (WHR) 0.5 2.1 5.2 1.9 -1.2 -1.4 -0.1 -2.3 -0.3
Systolic Blood Pressure 0.8 4.1 8.2 2.4 1.0 -2.6 -1.5 2.9 0.9
Smoking Status 1.6 3.9 9.5 1.3 -1.6 -2.5 -1.3 -1.3 -3.1
Allergy or Eczema 0.0 0.1 0.4 -0.5 0.2 0.2 0.6 0.1 -0.0
Cardiovascular Disease 0.7 2.3 4.2 1.9 0.8 -2.0 -1.0 1.1 1.8
Hypothyroidism (self reported) 0.3 0.8 2.4 -0.8 -0.0 1.0 0.4 1.5 0.8
Respiratory disease 0.4 0.8 2.7 -0.1 -0.3 1.6 -1.2 0.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.4 -1.6 -0.8 0.5 0.7 1.0 -1.9
Lung FEV1/FVC ratio 0.4 2.0 7.8 -0.7 -0.6 -0.7 -1.2 1.3 -2.8
Lung FVC 0.2 1.2 2.4 -1.5 1.5 -1.2 -0.5 1.0 -0.3
Neuroticism 0.9 2.1 8.4 0.6 -0.5 1.1 -0.3 2.9 -1.4
Chronotype (morning person) 0.5 1.2 4.5 -1.4 0.3 -0.2 0.5 2.1 -0.5
Hair Pigment 0.3 7.9 38.6 -0.2 -0.2 -2.2 -1.4 -1.2 -6.2
Tanning 0.1 0.7 2.4 -1.0 0.2 -0.1 0.4 1.6 0.9
Hand grip strength (left) 0.2 0.6 2.4 0.2 0.7 0.4 -0.4 -1.6 -0.3
Number of treatments/medications taken 0.2 0.4 1.1 0.0 -0.1 0.4 0.3 1.0 1.1
Average weekly spirits intake 2.2 2.8 5.1 1.7 -1.2 -1.9 -1.7 -2.3 -0.8
Sensitivity / hurt feelings 0.9 1.6 7.2 0.8 -0.4 -0.7 0.5 0.7 -2.7
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.0 1.0 -0.1 1.4 -0.0 1.4 -0.4
Hearing difficulty/problems: Yes 0.3 0.4 0.7 -0.2 -0.6 0.4 -0.8 0.8 -0.7
Relative age of first facial hair 0.4 0.8 3.0 -0.9 -0.2 -0.5 -1.7 -0.2 -0.6
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.4 -1.8 1.8 1.6 -0.2 1.2 0.8
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.5 0.5 -2.1 -0.0 -2.1 -0.0 -0.8
Ever had hysterectomy (womb removed) 0.7 0.7 2.2 0.6 -0.9 -0.7 -0.9 -1.5 -0.1
Systolic blood pressure, automated reading 1.0 3.0 11.9 1.5 0.1 -3.5 -1.6 1.0 -0.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.9 -0.7 -0.6 -1.7 1.0 -1.1 -0.9
Angina 0.3 0.4 1.3 0.4 -0.4 0.8 -0.4 1.1 -0.2
Medication for hormone replacement therapy 1.2 1.3 4.6 2.1 -0.8 -0.4 -1.3 -0.9 0.3
Vitamin and mineral supplements 0.3 0.4 1.2 -0.9 0.3 0.3 0.3 -0.1 -1.1
Supplements: Zinc 0.8 0.8 2.8 -1.7 -0.3 -0.5 -1.1 0.8 -0.1
Medication: Co-codamol 0.7 0.8 2.1 -0.8 -0.6 -0.1 1.5 0.8 0.8
Medication: Metformin 0.5 0.7 1.5 -0.7 -0.5 -1.2 -0.3 0.4 -1.2
Diabetes (father) 0.7 0.9 3.5 0.8 -1.9 -0.3 0.7 0.1 -0.8
Diabetes (mother) 1.3 1.7 6.3 -0.8 0.8 0.4 1.5 2.5 0.2
Severe depression (siblings) 1.2 1.3 4.5 -1.3 -0.5 0.8 -0.8 2.1 -0.4
Pack years adult smoking proportion 0.6 1.0 2.4 1.6 0.6 0.8 0.6 0.8 -1.2
Impedance of leg (right) 0.6 2.8 12.7 0.7 -0.5 0.1 0.0 -1.9 -3.6
Leg fat-free mass (left) 0.1 0.5 1.2 1.1 -1.0 -0.7 0.1 -0.5 0.3
Trunk fat percentage 0.3 1.3 4.1 -0.8 -0.5 -2.0 0.7 -0.0 -1.6
Hand grip strength (right) 0.6 1.5 3.8 1.4 -0.3 0.6 -1.5 -1.9 -0.9
Townsend deprivation index at recruitment 0.8 1.1 3.3 0.6 -1.2 0.5 1.0 1.8 0.0
Current tobacco smoking 0.2 0.3 0.7 0.8 -0.3 0.4 0.5 -0.4 -0.6
Average weekly fortified wine intake 0.3 0.3 0.7 -0.5 0.2 -0.5 -0.6 -0.5 0.9
Maternal smoking around birth 0.9 1.3 3.1 0.7 0.0 -1.2 1.4 0.7 1.8
Fed-up feelings 1.7 3.0 8.5 1.4 -0.4 1.0 -0.9 2.4 -2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 5.1 2.3 -0.3 1.4 0.3 0.9 -0.7
Relative age voice broke 0.8 1.3 3.8 0.2 -1.4 -0.9 -1.9 -0.5 -0.9
Taking other prescription medications 0.9 1.4 6.3 0.5 -1.0 0.6 0.4 0.2 2.5
Age when periods started (menarche) 0.3 0.8 1.5 -1.0 0.8 -0.8 -0.2 -1.2 0.8
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 3.3 1.0 -1.5 -1.0 -0.8 -0.6 -1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.7 -0.5 -0.8 -0.8 0.4 0.1 -0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.9 -1.4 0.4 -1.4 0.3 0.5 0.5
Qualifications: CSEs or equivalent 0.6 0.8 3.5 -0.0 -0.5 -1.0 1.9 0.3 -0.3
Serious illness, injury or assault to yourself 1.3 1.6 3.4 -1.4 1.0 1.6 0.7 1.8 -0.4
High blood pressure 0.5 1.5 5.2 0.8 0.5 -0.9 0.1 1.3 2.3
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.9 -0.6 0.3 -0.3 1.0 0.1 0.4
Multivitamins +/- minerals 0.2 0.2 0.5 0.7 -0.2 0.0 0.6 0.6 0.4
Stomach or abdominal pain in last month 0.8 1.0 2.7 0.6 -1.0 1.4 -0.2 -0.1 -1.7
Supplements: Glucosamine 0.5 0.6 1.7 0.5 0.3 0.7 -0.9 0.6 -1.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.0 0.1 -0.1 1.2 1.4 -0.9 -0.6
Medication: Atenolol 0.5 0.6 1.2 0.8 0.7 -0.9 -1.1 -0.4 0.5
Medication: Levothyroxine sodium 0.4 0.6 1.3 -0.8 -0.9 0.9 0.2 1.1 -0.1
Sitting height 0.2 1.6 5.3 1.7 -0.3 0.8 -0.4 -2.3 -0.9
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 -0.8 -0.7 0.4 0.7 -0.7 0.3
High blood pressure (mother) 1.1 1.5 4.0 2.0 -0.5 -1.0 -0.1 -0.8 1.8
Body mass index (BMI) 0.1 0.6 1.6 -0.5 -0.2 -1.2 0.7 1.0 0.1
Impedance of leg (left) 0.5 2.4 10.8 0.4 -0.8 -0.1 -0.3 -1.7 -3.3
Leg predicted mass (left) 0.1 0.5 1.1 1.1 -0.9 -0.7 0.1 -0.5 0.4
Trunk fat mass 0.2 0.9 2.1 -0.6 -0.4 -1.5 0.8 -0.0 -1.5
Waist circumference 0.2 0.8 2.9 0.4 -0.9 -1.7 0.5 0.1 -0.9
Number of incorrect matches in round 0.7 1.2 4.1 0.6 0.6 -0.2 -1.2 -0.9 2.0
Past tobacco smoking 1.0 1.8 5.5 -0.5 1.1 1.9 0.8 0.2 2.3
Alcohol usually taken with meals 0.7 1.1 3.9 -0.0 0.4 -2.0 -0.7 -1.3 -0.3
Nervous feelings 0.6 1.1 3.4 -0.4 0.6 1.8 0.6 1.4 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 5.6 0.3 -0.5 1.9 -1.4 2.4 -0.7
Hearing difficulty/problems with background noise 0.4 0.7 1.8 0.0 -1.0 1.2 -1.4 0.1 -0.2
Hair/balding pattern: Pattern 2 1.4 1.8 3.6 -1.4 1.0 1.9 0.6 0.5 -1.8
Had menopause 0.8 1.0 2.5 1.6 -1.0 -0.9 -1.0 0.8 0.4
Had other major operations 0.6 0.7 1.9 -0.1 -1.2 -0.7 0.3 0.7 1.4
Forced vital capacity (FVC) 0.2 0.7 1.4 0.1 0.8 -0.8 -1.2 -0.3 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.8 -0.5 -0.9 -0.7 0.7 0.5 -0.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.6 0.4 1.6 0.8 -0.1 1.6 1.4
Qualifications: None of the above 0.9 1.8 8.6 -1.1 0.3 0.3 0.1 2.9 -1.0
Financial difficulties in last 2 years 0.2 0.3 0.7 0.3 0.4 0.7 0.9 0.5 -0.3
Mouth/teeth dental problems 0.9 1.4 3.6 -1.1 1.2 0.4 -1.9 0.7 1.3
Heart attack 0.8 1.0 3.2 1.4 -0.6 0.7 0.2 -1.8 -0.2
Allergy 0.1 0.3 0.8 0.1 0.8 0.3 -0.5 0.4 0.9
Pain all over the body in last month 1.2 1.3 3.5 0.9 -1.6 -0.6 -1.9 0.7 -0.4
Diabetes (self-reported) 0.7 1.1 2.2 -1.5 0.4 0.8 1.3 0.7 -1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.1 -0.6 1.4 1.0 -0.2 1.0 -0.5
Medication: Ramipril 0.7 1.0 5.0 0.3 -0.1 0.5 0.4 0.4 2.2
Medication: Simvastatin 1.0 1.5 5.2 0.0 -0.0 -1.8 0.3 -0.7 2.3
Fluid intelligence score 0.4 0.8 2.5 -0.2 0.6 0.5 -0.9 -0.9 1.6
Illnesses of siblings 1.8 2.5 5.0 0.5 -2.2 -1.8 -0.6 -1.4 -2.0
Neuroticism score 0.6 1.2 4.1 0.3 -0.2 0.8 -0.7 2.0 -1.4
Weight 0.1 0.4 0.9 0.4 -0.7 -0.9 0.1 -0.2 -1.0
Impedance of arm (right) 0.2 0.7 3.6 0.0 0.4 -0.3 0.4 -0.6 -1.9
Arm fat percentage (right) 0.3 1.0 2.6 -0.8 0.3 -1.6 1.3 0.8 -0.7
Trunk fat-free mass 0.1 0.5 1.1 1.1 -0.7 0.6 -0.2 -0.9 -0.0
Hip circumference 0.1 0.6 1.9 -0.2 -0.2 -0.7 0.6 0.8 -1.4
Time employed in main current job 0.4 0.5 1.7 0.1 -1.0 0.0 -0.5 -1.3 0.3
Alcohol intake versus 10 years previously 0.5 0.7 2.4 -0.2 0.2 1.1 1.6 0.2 0.8
Father’s age at death 0.8 1.1 2.7 -0.6 -0.8 -1.6 -0.4 -1.6 -0.5
Worrier / anxious feelings 0.1 0.2 1.0 0.0 0.1 0.2 -0.2 1.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 10.5 1.5 -0.2 1.1 -1.4 3.2 -0.3
Falls in the last year 0.4 0.5 1.9 -0.7 0.2 -0.4 -0.3 1.4 0.4
Hair/balding pattern: Pattern 3 1.4 2.1 4.5 1.1 -1.4 -0.3 0.6 -2.0 2.1
Number of live births 0.6 0.9 2.0 1.4 -0.9 0.8 0.4 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.8 -0.1 0.6 -0.8 -1.5 -0.2 -1.7
Pulse rate 0.5 0.8 2.3 -0.9 -0.8 0.4 -0.8 1.5 -0.4
Happiness 1.3 1.6 3.8 0.6 1.5 1.2 -0.4 1.2 1.9
Noisy workplace 0.4 0.5 1.6 -0.7 -0.1 -0.2 1.3 -0.8 0.2
Qualifications: A levels/AS levels or equivalent 2.1 4.6 13.1 2.3 -1.5 -1.0 -2.3 -3.6 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.7 -0.4 -0.7 1.3 0.8 -0.1 0.9
Mouth/teeth dental problems: Dentures 0.6 1.0 2.8 0.3 -1.0 -0.2 1.7 0.5 -1.4
Asthma 0.3 0.7 2.2 0.6 -0.1 1.5 0.3 1.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.7 0.7 -1.5 -0.7 0.3 -2.2 0.5
Medication: Cholesterol lowering 1.2 1.8 6.7 0.4 -0.4 -1.8 -0.1 -0.9 2.6
Depression (self-reported) 0.8 1.0 2.6 0.6 -1.2 1.1 0.5 -1.6 -0.2
Medication: Lansoprazole 1.4 1.6 4.7 -1.4 -0.7 1.4 -0.4 -0.7 -2.2
Prospective memory result 0.2 0.3 1.3 -0.0 -0.2 0.2 0.3 1.1 0.2
Lung cancer (father) 1.8 2.2 4.8 -2.0 0.4 0.9 0.9 1.5 -2.2
Illnesses of mother 1.3 1.6 4.0 -2.0 1.3 1.3 -0.4 1.1 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.2 0.0 1.2 -1.0 -1.5 -0.2 -1.2
Pulse wave Arterial Stiffness index 1.5 1.7 6.7 -0.7 1.2 0.4 1.1 -0.7 2.6
Impedance of arm (left) 0.2 0.7 3.6 -0.2 0.2 -0.5 0.3 -0.6 -1.9
Arm fat mass (right) 0.1 0.6 2.3 -0.2 -0.3 -1.5 0.8 0.1 -0.7
Trunk predicted mass 0.1 0.5 1.2 1.1 -0.8 0.6 -0.1 -0.9 -0.0
Standing height 0.3 3.3 8.5 1.8 -1.0 0.8 -1.0 -2.9 -2.2
Length of working week for main job 0.2 0.3 0.6 0.3 0.5 0.8 -0.3 -0.6 -0.0
Exposure to tobacco smoke at home 2.5 2.8 9.3 0.6 -2.4 -3.0 -1.0 -0.8 -0.2
Breastfed as a baby 3.0 3.7 11.8 0.0 0.4 -3.4 -1.0 -1.1 2.8
Tense / ‘highly strung’ 0.2 0.3 0.5 0.4 -0.1 0.7 -0.5 0.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.9 -1.1 0.6 1.1 0.1 1.7 0.6
Hair/balding pattern: Pattern 4 1.0 2.4 9.1 -0.7 0.4 -0.5 -1.0 3.0 1.7
Birth weight of first child 0.4 0.7 2.0 1.1 0.3 -0.5 0.7 -1.4 0.4
Peak expiratory flow (PEF) 0.6 1.5 5.2 -0.4 -0.2 0.4 -2.3 0.4 -1.8
Pulse wave reflection index 1.4 1.7 3.8 -0.2 1.7 1.0 1.2 -1.2 1.9
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.8 1.7 0.2 0.6 1.3 -0.1 0.8
Loud music exposure frequency 1.1 1.2 5.2 0.1 1.0 -0.7 -0.3 2.3 -0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 3.6 1.9 -1.0 -0.4 0.0 -1.6 0.5
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 -0.5 -0.6 -0.8 0.8 -0.5 -0.5
Blood clot in the leg (DVT) 1.6 2.1 5.7 1.3 -1.5 -1.0 -0.3 -2.4 -1.3
Medication: Paracetamol 0.6 0.9 3.1 -0.5 -0.6 0.3 -0.6 1.2 1.8
Headache pain in last month 0.4 0.6 1.1 -0.7 -0.5 -0.3 0.9 1.0 1.1
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 4.0 0.2 -0.6 1.1 -0.0 -0.5 -2.0
Glaucoma (self-reported) 0.7 0.8 2.8 -0.3 -0.2 -0.0 -0.3 -1.7 1.4
Gout (self-reported) 0.5 0.7 2.0 0.4 0.5 -1.4 0.6 -0.6 1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.1 -0.1 -0.8 0.2 -0.6 1.0 0.8
Medication: Amlodipine 2.7 3.8 9.2 0.3 2.7 0.9 2.1 0.8 3.0
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.0 -0.5 -1.4 0.0 0.7 -0.3 -0.8
Birth weight 0.2 0.5 1.6 0.4 0.6 0.2 -0.0 -1.3 1.0
Chronic bronchitis/emphysema (mother) 1.2 1.4 3.6 0.2 1.2 1.9 0.7 0.7 1.6
High blood pressure (siblings) 0.7 1.0 2.1 -0.7 1.4 -0.1 -0.3 1.5 1.1
Forced vital capacity (FVC), Best measure 0.2 0.7 2.3 0.1 1.5 -0.6 -1.0 -0.7 -0.4
Body fat percentage 0.3 1.2 3.9 -0.7 -0.3 -2.0 0.8 0.2 -1.6
Leg fat percentage (right) 0.4 1.4 4.0 -0.5 -0.4 -1.8 0.9 0.2 -2.0
Arm fat-free mass (right) 0.2 0.8 2.0 1.3 -1.4 -0.3 -0.6 -0.9 -0.1
Exposure to tobacco smoke outside home 1.6 2.2 3.5 1.6 -1.4 -1.9 -1.2 0.7 -1.8
Comparative body size at age 10 0.5 1.3 5.0 1.4 0.0 -0.3 0.7 -2.2 0.7
Number of full brothers 0.2 0.3 0.8 -0.3 -0.5 -0.4 0.9 -0.5 0.5
Worry too long after embarrassment 0.6 0.9 2.1 -1.1 0.4 0.9 0.3 1.1 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.6 -0.9 0.4 0.1 -1.6 0.9 -0.0
Wheeze or whistling in the chest in last year 0.3 0.6 2.8 0.5 -0.5 0.4 0.3 -0.2 1.7
Number of children fathered 2.1 2.3 4.3 -0.9 0.8 2.1 1.5 2.0 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 4.8 -0.4 0.5 -0.5 -2.2 0.6 0.8
Age at first live birth 1.0 1.9 8.9 0.3 -0.4 -1.0 -0.0 -3.0 1.0
Pulse wave peak to peak time 1.7 2.0 7.2 1.1 -1.2 -0.5 -1.2 0.4 -2.7
Health satisfaction 0.4 0.5 2.4 0.5 0.1 0.3 -0.3 -0.3 1.5
Shortness of breath walking on level ground 0.7 0.9 1.7 1.3 -1.0 0.7 -0.5 -0.7 -1.0
Qualifications: College or University degree 0.8 2.4 4.9 0.8 1.1 -1.1 -1.9 -1.7 2.2
Eye problems/disorders: None of the above 0.6 0.6 2.9 -0.5 -0.1 0.6 1.7 -0.1 0.6
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.5 1.3 -0.5 -0.2 -0.4 -1.4 1.9
Emphysema/chronic bronchitis 1.5 1.7 6.4 0.3 -1.0 -2.5 -1.5 -0.5 -0.7
Medication for pain relief, constipation, heartburn 1.0 1.8 4.6 -0.8 1.7 1.1 0.3 1.1 -2.1
Neck or shoulder pain in last month 0.4 0.6 1.2 1.1 -0.8 0.6 -0.7 0.6 -0.5
Medication: Blood pressure 0.4 0.7 1.2 -0.9 0.9 -0.9 0.1 1.0 1.1
Angina (self-reported) 0.4 0.5 1.3 0.5 -0.3 1.1 -0.3 1.2 -0.1
Migraine (self-reported) 1.1 1.4 6.7 -0.4 0.1 0.4 0.5 1.1 2.6
Medication: Ibuprofen 0.8 1.0 2.7 0.7 -1.6 -0.4 0.4 -1.6 -0.5
Medication: Allopurinol 0.8 1.0 2.0 0.6 1.2 -1.4 0.2 -0.6 1.4
Medication: Omeprazole 1.3 1.5 4.2 0.4 -0.5 -0.1 -2.1 -1.9 1.0
Medication: Seretide 50 evohaler 1.8 2.1 5.7 0.5 -2.4 -1.2 -0.1 -2.2 -0.5
Mean time to correctly identify matches 0.5 1.0 3.8 -0.5 0.9 0.8 -0.5 1.9 0.2
Heart disease (mother) 3.7 4.6 13.0 1.5 -2.4 -3.6 -2.3 -0.5 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.5 1.8 -0.4 0.5 -0.9 0.2 1.4 -0.2
Whole body fat mass 0.2 0.8 2.0 -0.1 -0.4 -1.4 0.8 -0.2 -1.4
Leg fat mass (right) 0.3 1.1 2.9 0.3 -1.0 -1.7 0.4 -0.3 -1.6
Arm predicted mass (right) 0.1 0.8 2.0 1.1 -1.4 -0.2 -0.7 -0.9 0.0
Pulse rate, automated reading 0.3 1.0 2.3 -1.2 -0.8 1.1 -0.2 0.4 -1.5
Alcohol intake frequency. 0.5 1.1 4.6 -0.2 -0.1 0.9 0.1 2.1 -1.2
Comparative height size at age 10 0.2 1.2 3.1 1.8 -0.8 -0.0 0.5 -1.0 -1.4
Number of full sisters 1.0 1.3 3.0 1.7 -1.5 1.2 0.8 0.3 0.5
Suffer from ‘nerves’ 0.2 0.3 0.9 0.4 0.3 1.0 -0.8 0.6 0.0
Overall health rating 0.5 1.1 5.2 -0.4 0.1 0.9 0.8 2.3 -0.1
Chest pain or discomfort 0.3 0.5 0.9 0.9 0.3 -0.6 -0.2 0.9 -0.7
Had major operations 1.1 1.3 3.7 -1.7 -0.6 1.9 -0.7 0.0 -0.7
Age at last live birth 0.4 0.6 2.7 -0.2 -0.4 -0.3 -0.3 -1.6 0.8
Family relationship satisfaction 1.6 2.0 4.6 -1.5 2.1 0.3 -0.6 1.9 1.1
Leg pain on walking 1.1 1.3 2.9 -1.4 0.7 0.8 0.6 1.7 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 0.2 -0.4 -0.8 0.7 -0.2 -0.2
Commuting to job workplace: Car/motor vehicle 1.2 1.3 6.0 0.9 0.6 -0.4 0.7 -2.4 -0.5
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 6.9 1.4 -0.9 -1.1 0.4 -2.6 -0.5
Medication: Aspirin 0.7 0.9 2.8 0.2 -0.9 -1.7 -1.0 -0.9 0.6
Supplements: Vitamin C 0.7 0.9 2.1 -0.1 -1.3 -0.6 -0.8 -0.6 1.5
Knee pain experienced in last month 1.0 1.5 6.7 -1.3 0.0 -0.1 0.8 2.6 0.2
Hypertension (Self-reported) 0.5 1.5 5.1 0.6 0.7 -1.2 0.0 1.4 2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 3.2 -0.0 0.2 0.4 -1.8 -1.4 -0.1
Illnesses of father: Heart disease 1.0 1.4 3.4 1.8 -0.3 -1.3 -1.7 -0.3 -0.6
Illnesses of siblings: Diabetes 0.8 1.0 2.4 -1.5 -0.2 1.3 0.1 0.6 -1.3
Smoking status: Previous 2.3 3.4 9.1 0.3 -1.7 -2.3 -1.8 0.1 -3.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 3.4 0.4 -0.1 0.4 1.8 -0.1 0.1
Whole body fat-free mass 0.1 0.5 1.4 1.2 -1.0 -0.1 -0.2 -0.8 0.2
Leg fat-free mass (right) 0.1 0.5 0.8 0.9 -0.9 -0.6 -0.1 -0.4 0.8
Arm fat percentage (left) 0.3 1.2 3.1 -0.7 0.0 -1.8 1.3 0.9 -0.9
Average weekly red wine intake 0.3 0.5 1.4 -0.7 1.2 -0.7 -0.2 0.8 0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.0 -1.4 1.1 -0.8 0.2 0.2 -1.0
Mood swings 1.0 1.8 7.0 0.0 -0.5 -0.1 -1.8 2.6 -0.8
Loneliness, isolation 1.7 2.3 3.8 2.0 -1.9 -0.5 -0.6 1.9 -1.4
Long-standing illness, disability or infirmity 1.2 1.9 5.1 -2.1 0.2 1.3 0.7 2.2 0.2
Ever had bowel cancer screening 0.9 1.1 3.6 -1.1 -0.6 0.3 0.3 -1.1 -1.9
Diabetes diagnosed by doctor 0.6 1.0 2.3 -1.4 0.1 0.1 0.9 1.0 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 1.1 -0.7 0.1 0.3 -0.6 -0.5
Friendships satisfaction 0.7 0.9 1.9 -0.5 0.5 -1.4 -1.3 1.0 0.2
Qualifications: nursing, teaching 0.8 1.2 3.9 0.1 -1.2 -2.0 -1.0 -0.8 0.3
Commuting to job workplace: Walk 2.2 2.3 5.1 -1.8 -0.4 -0.4 -0.7 2.2 -2.3
Eye problems/disorders: Cataract 0.4 0.4 1.7 0.6 -0.0 -0.2 -0.5 0.2 -1.3
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 5.3 2.3 -1.9 -1.7 -0.8 -0.5 0.5
Medication for cholesterol 0.6 0.9 2.0 -1.4 -0.0 1.2 0.6 0.2 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 8.7 1.8 -3.0 -0.2 -0.9 -1.5 0.9
Back pain experienced in last month 0.6 0.9 1.6 1.1 -1.2 1.3 -0.5 -0.6 0.1
Mineral and other dietary supplements 0.2 0.3 0.9 -1.0 0.3 0.0 -0.7 -0.2 0.2
Breast cancer (self-reported) 0.3 0.3 1.5 0.1 0.4 -0.5 -0.3 1.2 0.1
Asthma (self-reported) 0.3 0.7 2.0 0.6 -0.5 1.4 0.2 1.2 0.1
Osteoporosis (self-reported) 1.5 1.9 3.3 -1.3 0.9 1.8 1.8 1.4 -0.5
Osteoarthritis (self-reported) 0.6 0.8 4.3 -0.4 0.2 -2.1 0.1 -0.2 -0.2
Medication: Aspirin 0.6 0.8 2.2 0.3 -0.7 -1.5 -0.9 -0.9 0.4
Medication: Gliclazide 0.6 0.7 2.4 0.1 -0.3 -0.5 0.9 -1.6 -0.5
Illnesses of father: None of the above (group 1) 0.8 1.0 1.5 -1.1 0.8 1.2 1.2 1.0 -0.3
Smoking status: Current 0.3 0.4 1.2 1.1 -0.0 0.1 0.6 -0.8 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 5.6 -0.7 2.4 -0.9 -2.2 0.9 1.1
Whole body water mass 0.1 0.5 1.3 1.1 -1.0 0.0 -0.1 -0.8 0.2
Leg predicted mass (right) 0.1 0.6 1.1 1.1 -0.9 -0.6 -0.2 -0.5 0.8
Arm fat mass (left) 0.1 0.6 1.9 -0.2 -0.1 -1.4 0.9 0.4 -0.9
Number of self-reported non-cancer illnesses 0.8 1.3 6.4 -0.3 0.7 0.9 -0.5 0.1 2.5
Average weekly champagne plus white wine intake 0.6 0.8 1.9 -0.2 0.2 -1.1 -0.1 -1.4 1.3
Miserableness 0.8 1.4 3.6 1.6 -0.9 0.7 -0.7 1.9 -0.5
Guilty feelings 0.1 0.2 0.7 0.8 -0.0 0.5 0.3 0.1 0.5
Wears glasses or contact lenses 0.2 0.2 1.0 -1.0 -0.2 0.4 0.1 0.3 -0.1
Ever taken oral contraceptive pill 0.4 0.5 1.4 -0.9 0.8 0.2 -0.2 1.2 0.3
Hearing aid user 0.8 0.9 2.5 -0.8 -0.5 -1.1 0.1 -0.6 -1.6
Mother’s age at death 0.9 1.2 4.8 -0.6 2.2 0.7 0.7 0.6 0.7
Financial situation satisfaction 0.2 0.2 0.7 -0.3 0.8 -0.3 0.0 0.0 -0.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.4 1.0 0.1 -0.2 0.1 1.1 1.2
Commuting to job workplace: Public transport 1.4 1.7 5.2 -1.8 1.1 0.7 0.4 2.3 -0.3
Eye problems/disorders: Glaucoma 0.2 0.3 0.9 0.0 0.0 0.7 0.0 -0.9 0.6
Medication: Blood pressure 0.7 1.3 5.2 1.2 0.0 0.2 -0.6 0.7 2.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.4 -0.1 -0.5 -0.7 0.5 0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.9 2.0 -0.2 -0.6 1.6 -0.8 0.4
High cholesterol (Self-reported) 2.8 5.0 17.8 0.7 1.3 -2.1 0.6 -2.3 4.2
Medication: Bendroflumethiazide 0.9 1.3 3.9 0.3 -2.0 -1.1 -0.5 1.5 0.7
Medication: Paracetamol 0.6 0.9 2.7 -1.1 -0.6 0.4 -0.3 1.6 1.0
Medication: Lisinopril 0.3 0.3 1.1 -0.5 -0.6 -0.5 0.4 0.3 -1.0
Medication: Atorvastatin 1.7 2.2 5.2 -0.6 2.2 0.6 1.2 -0.9 2.3
Illnesses of father: High blood pressure 0.4 0.5 1.0 -0.3 0.7 -0.9 -0.2 0.6 1.0
Alcohol drinker status: Never 0.7 0.8 1.8 0.7 -1.3 0.5 -0.8 -0.2 -1.3
Ever smoked 0.5 0.9 1.2 0.9 -1.1 -1.1 0.1 -1.0 -1.1
Basal metabolic rate 0.1 0.5 1.1 1.0 -1.0 -0.4 -0.1 -0.8 -0.2
Leg fat percentage (left) 0.3 1.2 2.9 -0.7 -0.3 -1.7 1.0 0.3 -1.7
Arm fat-free mass (left) 0.1 0.5 1.0 1.0 -0.9 -0.3 -0.5 -0.7 -0.3
Number of operations (self-reported) 0.7 1.0 3.5 -0.6 -1.9 0.5 -1.1 -0.4 0.6
Average weekly beer plus cider intake 0.5 0.8 1.4 -0.6 -0.8 1.1 -0.2 1.2 0.9
Irritability 1.7 2.9 5.1 -1.5 1.8 1.5 2.1 2.3 -0.4
Risk taking 1.2 1.7 3.5 -0.7 1.0 -1.7 -0.7 1.4 -1.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.4 -0.8 0.9 0.1 -0.1 1.2 0.5
Fractured/broken bones in last 5 years 0.9 1.2 2.2 0.9 1.1 0.9 -0.8 1.2 1.5
Age started oral contraceptive pill 0.4 0.5 0.8 -0.5 0.9 0.1 -0.9 0.2 0.9
Diastolic blood pressure, automated reading 0.4 1.3 3.5 0.1 -0.6 -1.9 -0.1 0.8 -1.8
Ever depressed for a whole week 1.0 1.2 2.0 0.5 1.3 -0.1 1.2 1.4 1.3
Unable to work because of sickness or disability 0.6 0.8 2.6 -0.5 -0.6 -1.0 -0.2 1.6 -0.6
Commuting to job workplace: Cycle 0.5 0.7 2.3 0.5 -0.1 0.4 -1.1 1.5 0.2
Myopia 0.2 0.3 0.6 0.2 0.5 0.5 0.0 0.8 -0.8
Vascular/heart problems diagnosed by doctor 0.5 1.4 4.7 -1.3 -0.2 0.9 0.1 -1.1 -2.2
Cholesterol lowering medication 1.2 1.8 6.7 -0.2 0.7 -1.5 0.7 -0.8 2.6
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 4.6 -0.3 -0.0 0.5 -1.1 -2.1 1.4
Pain experienced in last month 0.4 0.6 1.5 -0.1 1.2 -0.7 -0.4 -1.2 0.2
Supplements: Calcium 0.2 0.3 1.2 0.4 -0.4 0.0 0.1 -0.1 1.1
Basal cell carcinoma (self-reported) 0.7 0.8 1.3 -1.0 0.1 1.2 -1.0 0.4 1.1
Heart attack/myocardial infarction (self-reported) 0.8 1.1 2.9 1.4 -0.6 0.9 -0.0 -1.7 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.6 2.0 5.9 0.8 -1.5 -1.0 -0.1 -2.4 -1.6
Heart disease (siblings) 1.1 1.4 3.5 1.3 -0.1 0.8 0.8 -1.4 1.9
Alcohol drinker status: Previous 2.4 2.7 7.0 -1.1 -1.8 1.3 -0.9 1.5 -2.6
Pack years of smoking 0.6 0.9 2.5 1.6 0.3 0.7 0.5 0.4 -1.4
Impedance of whole body 0.3 1.5 7.7 -0.0 -0.1 -0.1 0.0 -1.2 -2.8
Leg fat mass (left) 0.3 1.0 2.7 0.1 -1.0 -1.6 0.5 -0.3 -1.4
Arm predicted mass (left) 0.1 0.6 1.3 1.1 -0.9 -0.3 -0.7 -0.8 -0.4