Hub : Genes

HS1BP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0270	1.3e-03	0.026	0.012	0.005	0.017	0.019	3.6e-04	1.0e-02	6.9e-02	3.3e-03	1.7e-03
2	GTEx	Artery Tibial	0.1226	0.0442	5.7e-03	0.061	NA	0.076	NA	0.087	1.5e-05	NA	1.5e-06	NA	2.4e-07
3	GTEx	Esophagus Mucosa	0.1650	0.0580	5.4e-03	-0.004	NA	-0.002	NA	-0.003	6.9e-01	NA	4.8e-01	NA	5.7e-01
4	METSIM	Adipose	0.0837	0.0276	1.6e-04	-0.002	0.021	0.017	0.022	0.000	7.4e-01	3.6e-04	1.3e-03	2.7e-04	2.8e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.1011	0.0298	9.7e-05	0.006	0.032	0.013	0.030	0.013	4.6e-02	4.6e-05	7.1e-03	7.9e-05	7.6e-03
6	YFS	Blood	0.0256	0.0098	1.8e-03	0.004	0.009	0.003	0.008	0.003	1.2e-02	3.7e-04	3.2e-02	1.2e-03	2.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	3.3	1.3	-1.6	-0.3	0.5	-1.8	0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	-0.4	-1.1	-0.3	0.5	1.0	-0.1
Depressed Affect (Nagel 2018)	1.2	2.5	6.3	0.7	-2.1	0.9	-0.9	2.5	-1.3
Depression (Nagel 2018)	0.5	0.8	2.5	1.6	-0.0	0.8	0.6	0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.7	0.8	0.1	-1.3	-1.9	-0.1	1.6
Neuroticism (Nagel 2018)	0.4	1.1	4.4	-0.1	-0.8	0.9	0.2	2.1	-0.7
Schizophrenia (2018)	0.8	1.7	7.4	-1.6	-0.1	-0.3	0.3	2.7	-0.5
Schizophrenia vs Biploar Disorder	0.6	0.8	1.9	-0.2	1.0	0.9	-0.9	1.4	-0.3
Worry (Nagel 2018)	0.2	0.4	1.5	-0.5	0.1	0.6	-0.4	1.2	-0.1
Alzheimer’s Disease (in mother)	2.1	2.5	6.0	1.0	-1.8	-2.5	-1.5	-0.6	-1.4
Alzheimer’s Disease (in father)	0.4	0.5	1.2	0.7	0.9	0.5	-0.4	-0.3	1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.9	0.9	-0.4	-1.4	-0.4	-0.4	0.0
Crohns Disease (2017)	0.4	0.8	1.3	0.3	-1.1	-1.1	-0.5	-0.8	-1.2
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	0.6	-0.9	-1.0	-1.9	-0.7	-0.9
Ulcerative Colitis (UC)	0.7	1.4	5.6	1.0	-0.3	-0.8	-2.4	0.0	-0.9
Major Depression (MDD)	0.8	1.0	2.8	0.0	0.0	1.7	1.4	0.8	0.9
Reaction Time	1.2	2.2	9.3	-1.0	1.6	0.4	-0.4	3.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.3	0.2	0.5	0.1	-0.7	-0.7	2.1
Breast Cancer	0.3	0.8	2.2	0.6	1.5	0.9	0.8	-0.5	0.4
Ovarian Cancer	0.6	0.8	1.6	-1.2	-0.6	-0.6	-1.0	1.1	-0.5
Prostate Cancer	1.6	2.3	5.1	1.4	-2.3	2.1	-0.2	-0.5	-1.3
Age at First Birth	0.2	0.4	0.7	0.8	-0.6	-0.1	-0.7	-0.7	-0.2
Bipolar Disorder (2011)	1.8	1.7	6.2	2.5	-1.9	-0.5	-0.5	-0.2	0.6
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	-0.6	-1.1	0.4	0.6	-0.2	0.1
Coronary Artery Disease (CAD)	0.4	0.4	1.0	0.9	-0.1	0.2	0.8	-0.3	1.0
Crohns Disease (2012)	0.5	0.8	1.8	0.3	-0.3	-1.3	0.2	-1.3	-1.1
Mean Putamen Volume	0.3	0.3	0.7	-0.4	-0.9	-0.1	-0.7	0.7	-0.4
Fasting Glucose	0.7	0.9	3.0	-1.1	0.2	1.7	0.9	0.4	0.5
HbA1C	0.5	0.6	1.2	0.8	-1.1	-0.5	0.2	-1.1	-0.3
HDL Cholesterol	6.0	10.1	29.4	1.0	-1.5	-2.4	-4.7	0.4	-5.4
LDL Cholesterol	6.7	10.6	44.0	1.7	2.7	-1.7	-0.9	-2.4	6.6
Lupus	0.3	0.5	1.6	-0.0	-0.3	-1.3	0.4	0.9	0.4
Neuroticism (2016)	0.8	1.1	3.5	-0.1	0.7	1.1	0.9	1.9	-0.9
Primary Biliary Cirrhosis	1.9	2.7	8.1	0.7	-1.3	-2.8	-1.1	-0.8	-2.0
Rheumatoid Arthritis	0.4	0.6	2.8	0.7	-1.7	-0.3	-0.3	0.2	0.3
Schizophrenia (2014)	0.6	1.2	4.7	-1.2	-0.8	-0.5	0.0	2.2	-0.6
Triglycerides	7.3	12.0	28.3	-0.2	2.3	3.1	5.3	0.4	5.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.5	-1.4	-0.7	-0.2	-0.1	1.2	-2.1
Ulcerative Colitis	0.1	0.1	0.3	-0.4	0.4	-0.2	-0.2	0.6	0.1
Blood Eosinophil Count	0.1	0.5	1.5	0.4	-1.0	-1.2	0.1	-0.4	0.6
Blood Platelet Count	0.3	3.1	6.1	1.0	1.1	-1.6	-2.5	1.2	-2.4
Blood Red Count	0.5	4.6	16.7	0.8	0.6	-1.8	-2.0	1.6	-4.1
Blood White Count	0.2	1.2	2.6	1.0	0.3	-0.8	-0.4	1.6	-1.6
Heel T-Score	0.3	2.5	4.8	0.5	-0.2	-2.2	-1.6	1.6	-2.2
BMI	0.2	1.3	4.8	-0.3	-1.1	-2.2	-0.0	1.1	-0.6
Height	0.6	10.9	36.2	4.2	-1.6	0.9	-1.6	-6.0	-2.4
Waist Hip Ratio (WHR)	0.5	2.1	5.2	1.9	-1.2	-1.4	-0.1	-2.3	-0.3
Systolic Blood Pressure	0.8	4.1	8.2	2.4	1.0	-2.6	-1.5	2.9	0.9
Smoking Status	1.6	3.9	9.5	1.3	-1.6	-2.5	-1.3	-1.3	-3.1
Allergy or Eczema	0.0	0.1	0.4	-0.5	0.2	0.2	0.6	0.1	-0.0
Cardiovascular Disease	0.7	2.3	4.2	1.9	0.8	-2.0	-1.0	1.1	1.8
Hypothyroidism (self reported)	0.3	0.8	2.4	-0.8	-0.0	1.0	0.4	1.5	0.8
Respiratory disease	0.4	0.8	2.7	-0.1	-0.3	1.6	-1.2	0.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.4	3.4	-1.6	-0.8	0.5	0.7	1.0	-1.9
Lung FEV1/FVC ratio	0.4	2.0	7.8	-0.7	-0.6	-0.7	-1.2	1.3	-2.8
Lung FVC	0.2	1.2	2.4	-1.5	1.5	-1.2	-0.5	1.0	-0.3
Neuroticism	0.9	2.1	8.4	0.6	-0.5	1.1	-0.3	2.9	-1.4
Chronotype (morning person)	0.5	1.2	4.5	-1.4	0.3	-0.2	0.5	2.1	-0.5
Hair Pigment	0.3	7.9	38.6	-0.2	-0.2	-2.2	-1.4	-1.2	-6.2
Tanning	0.1	0.7	2.4	-1.0	0.2	-0.1	0.4	1.6	0.9
Hand grip strength (left)	0.2	0.6	2.4	0.2	0.7	0.4	-0.4	-1.6	-0.3
Number of treatments/medications taken	0.2	0.4	1.1	0.0	-0.1	0.4	0.3	1.0	1.1
Average weekly spirits intake	2.2	2.8	5.1	1.7	-1.2	-1.9	-1.7	-2.3	-0.8
Sensitivity / hurt feelings	0.9	1.6	7.2	0.8	-0.4	-0.7	0.5	0.7	-2.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	1.0	-0.1	1.4	-0.0	1.4	-0.4
Hearing difficulty/problems: Yes	0.3	0.4	0.7	-0.2	-0.6	0.4	-0.8	0.8	-0.7
Relative age of first facial hair	0.4	0.8	3.0	-0.9	-0.2	-0.5	-1.7	-0.2	-0.6
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.4	-1.8	1.8	1.6	-0.2	1.2	0.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.5	0.5	-2.1	-0.0	-2.1	-0.0	-0.8
Ever had hysterectomy (womb removed)	0.7	0.7	2.2	0.6	-0.9	-0.7	-0.9	-1.5	-0.1
Systolic blood pressure, automated reading	1.0	3.0	11.9	1.5	0.1	-3.5	-1.6	1.0	-0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.9	-0.7	-0.6	-1.7	1.0	-1.1	-0.9
Angina	0.3	0.4	1.3	0.4	-0.4	0.8	-0.4	1.1	-0.2
Medication for hormone replacement therapy	1.2	1.3	4.6	2.1	-0.8	-0.4	-1.3	-0.9	0.3
Vitamin and mineral supplements	0.3	0.4	1.2	-0.9	0.3	0.3	0.3	-0.1	-1.1
Supplements: Zinc	0.8	0.8	2.8	-1.7	-0.3	-0.5	-1.1	0.8	-0.1
Medication: Co-codamol	0.7	0.8	2.1	-0.8	-0.6	-0.1	1.5	0.8	0.8
Medication: Metformin	0.5	0.7	1.5	-0.7	-0.5	-1.2	-0.3	0.4	-1.2
Diabetes (father)	0.7	0.9	3.5	0.8	-1.9	-0.3	0.7	0.1	-0.8
Diabetes (mother)	1.3	1.7	6.3	-0.8	0.8	0.4	1.5	2.5	0.2
Severe depression (siblings)	1.2	1.3	4.5	-1.3	-0.5	0.8	-0.8	2.1	-0.4
Pack years adult smoking proportion	0.6	1.0	2.4	1.6	0.6	0.8	0.6	0.8	-1.2
Impedance of leg (right)	0.6	2.8	12.7	0.7	-0.5	0.1	0.0	-1.9	-3.6
Leg fat-free mass (left)	0.1	0.5	1.2	1.1	-1.0	-0.7	0.1	-0.5	0.3
Trunk fat percentage	0.3	1.3	4.1	-0.8	-0.5	-2.0	0.7	-0.0	-1.6
Hand grip strength (right)	0.6	1.5	3.8	1.4	-0.3	0.6	-1.5	-1.9	-0.9
Townsend deprivation index at recruitment	0.8	1.1	3.3	0.6	-1.2	0.5	1.0	1.8	0.0
Current tobacco smoking	0.2	0.3	0.7	0.8	-0.3	0.4	0.5	-0.4	-0.6
Average weekly fortified wine intake	0.3	0.3	0.7	-0.5	0.2	-0.5	-0.6	-0.5	0.9
Maternal smoking around birth	0.9	1.3	3.1	0.7	0.0	-1.2	1.4	0.7	1.8
Fed-up feelings	1.7	3.0	8.5	1.4	-0.4	1.0	-0.9	2.4	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	5.1	2.3	-0.3	1.4	0.3	0.9	-0.7
Relative age voice broke	0.8	1.3	3.8	0.2	-1.4	-0.9	-1.9	-0.5	-0.9
Taking other prescription medications	0.9	1.4	6.3	0.5	-1.0	0.6	0.4	0.2	2.5
Age when periods started (menarche)	0.3	0.8	1.5	-1.0	0.8	-0.8	-0.2	-1.2	0.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.3	1.0	-1.5	-1.0	-0.8	-0.6	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	-0.5	-0.8	-0.8	0.4	0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	-1.4	0.4	-1.4	0.3	0.5	0.5
Qualifications: CSEs or equivalent	0.6	0.8	3.5	-0.0	-0.5	-1.0	1.9	0.3	-0.3
Serious illness, injury or assault to yourself	1.3	1.6	3.4	-1.4	1.0	1.6	0.7	1.8	-0.4
High blood pressure	0.5	1.5	5.2	0.8	0.5	-0.9	0.1	1.3	2.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.9	-0.6	0.3	-0.3	1.0	0.1	0.4
Multivitamins +/- minerals	0.2	0.2	0.5	0.7	-0.2	0.0	0.6	0.6	0.4
Stomach or abdominal pain in last month	0.8	1.0	2.7	0.6	-1.0	1.4	-0.2	-0.1	-1.7
Supplements: Glucosamine	0.5	0.6	1.7	0.5	0.3	0.7	-0.9	0.6	-1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	0.1	-0.1	1.2	1.4	-0.9	-0.6
Medication: Atenolol	0.5	0.6	1.2	0.8	0.7	-0.9	-1.1	-0.4	0.5
Medication: Levothyroxine sodium	0.4	0.6	1.3	-0.8	-0.9	0.9	0.2	1.1	-0.1
Sitting height	0.2	1.6	5.3	1.7	-0.3	0.8	-0.4	-2.3	-0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	-0.8	-0.7	0.4	0.7	-0.7	0.3
High blood pressure (mother)	1.1	1.5	4.0	2.0	-0.5	-1.0	-0.1	-0.8	1.8
Body mass index (BMI)	0.1	0.6	1.6	-0.5	-0.2	-1.2	0.7	1.0	0.1
Impedance of leg (left)	0.5	2.4	10.8	0.4	-0.8	-0.1	-0.3	-1.7	-3.3
Leg predicted mass (left)	0.1	0.5	1.1	1.1	-0.9	-0.7	0.1	-0.5	0.4
Trunk fat mass	0.2	0.9	2.1	-0.6	-0.4	-1.5	0.8	-0.0	-1.5
Waist circumference	0.2	0.8	2.9	0.4	-0.9	-1.7	0.5	0.1	-0.9
Number of incorrect matches in round	0.7	1.2	4.1	0.6	0.6	-0.2	-1.2	-0.9	2.0
Past tobacco smoking	1.0	1.8	5.5	-0.5	1.1	1.9	0.8	0.2	2.3
Alcohol usually taken with meals	0.7	1.1	3.9	-0.0	0.4	-2.0	-0.7	-1.3	-0.3
Nervous feelings	0.6	1.1	3.4	-0.4	0.6	1.8	0.6	1.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.6	0.3	-0.5	1.9	-1.4	2.4	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.8	0.0	-1.0	1.2	-1.4	0.1	-0.2
Hair/balding pattern: Pattern 2	1.4	1.8	3.6	-1.4	1.0	1.9	0.6	0.5	-1.8
Had menopause	0.8	1.0	2.5	1.6	-1.0	-0.9	-1.0	0.8	0.4
Had other major operations	0.6	0.7	1.9	-0.1	-1.2	-0.7	0.3	0.7	1.4
Forced vital capacity (FVC)	0.2	0.7	1.4	0.1	0.8	-0.8	-1.2	-0.3	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	-0.5	-0.9	-0.7	0.7	0.5	-0.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.6	0.4	1.6	0.8	-0.1	1.6	1.4
Qualifications: None of the above	0.9	1.8	8.6	-1.1	0.3	0.3	0.1	2.9	-1.0
Financial difficulties in last 2 years	0.2	0.3	0.7	0.3	0.4	0.7	0.9	0.5	-0.3
Mouth/teeth dental problems	0.9	1.4	3.6	-1.1	1.2	0.4	-1.9	0.7	1.3
Heart attack	0.8	1.0	3.2	1.4	-0.6	0.7	0.2	-1.8	-0.2
Allergy	0.1	0.3	0.8	0.1	0.8	0.3	-0.5	0.4	0.9
Pain all over the body in last month	1.2	1.3	3.5	0.9	-1.6	-0.6	-1.9	0.7	-0.4
Diabetes (self-reported)	0.7	1.1	2.2	-1.5	0.4	0.8	1.3	0.7	-1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-0.6	1.4	1.0	-0.2	1.0	-0.5
Medication: Ramipril	0.7	1.0	5.0	0.3	-0.1	0.5	0.4	0.4	2.2
Medication: Simvastatin	1.0	1.5	5.2	0.0	-0.0	-1.8	0.3	-0.7	2.3
Fluid intelligence score	0.4	0.8	2.5	-0.2	0.6	0.5	-0.9	-0.9	1.6
Illnesses of siblings	1.8	2.5	5.0	0.5	-2.2	-1.8	-0.6	-1.4	-2.0
Neuroticism score	0.6	1.2	4.1	0.3	-0.2	0.8	-0.7	2.0	-1.4
Weight	0.1	0.4	0.9	0.4	-0.7	-0.9	0.1	-0.2	-1.0
Impedance of arm (right)	0.2	0.7	3.6	0.0	0.4	-0.3	0.4	-0.6	-1.9
Arm fat percentage (right)	0.3	1.0	2.6	-0.8	0.3	-1.6	1.3	0.8	-0.7
Trunk fat-free mass	0.1	0.5	1.1	1.1	-0.7	0.6	-0.2	-0.9	-0.0
Hip circumference	0.1	0.6	1.9	-0.2	-0.2	-0.7	0.6	0.8	-1.4
Time employed in main current job	0.4	0.5	1.7	0.1	-1.0	0.0	-0.5	-1.3	0.3
Alcohol intake versus 10 years previously	0.5	0.7	2.4	-0.2	0.2	1.1	1.6	0.2	0.8
Father’s age at death	0.8	1.1	2.7	-0.6	-0.8	-1.6	-0.4	-1.6	-0.5
Worrier / anxious feelings	0.1	0.2	1.0	0.0	0.1	0.2	-0.2	1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	10.5	1.5	-0.2	1.1	-1.4	3.2	-0.3
Falls in the last year	0.4	0.5	1.9	-0.7	0.2	-0.4	-0.3	1.4	0.4
Hair/balding pattern: Pattern 3	1.4	2.1	4.5	1.1	-1.4	-0.3	0.6	-2.0	2.1
Number of live births	0.6	0.9	2.0	1.4	-0.9	0.8	0.4	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.8	-0.1	0.6	-0.8	-1.5	-0.2	-1.7
Pulse rate	0.5	0.8	2.3	-0.9	-0.8	0.4	-0.8	1.5	-0.4
Happiness	1.3	1.6	3.8	0.6	1.5	1.2	-0.4	1.2	1.9
Noisy workplace	0.4	0.5	1.6	-0.7	-0.1	-0.2	1.3	-0.8	0.2
Qualifications: A levels/AS levels or equivalent	2.1	4.6	13.1	2.3	-1.5	-1.0	-2.3	-3.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.7	-0.4	-0.7	1.3	0.8	-0.1	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	2.8	0.3	-1.0	-0.2	1.7	0.5	-1.4
Asthma	0.3	0.7	2.2	0.6	-0.1	1.5	0.3	1.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.7	0.7	-1.5	-0.7	0.3	-2.2	0.5
Medication: Cholesterol lowering	1.2	1.8	6.7	0.4	-0.4	-1.8	-0.1	-0.9	2.6
Depression (self-reported)	0.8	1.0	2.6	0.6	-1.2	1.1	0.5	-1.6	-0.2
Medication: Lansoprazole	1.4	1.6	4.7	-1.4	-0.7	1.4	-0.4	-0.7	-2.2
Prospective memory result	0.2	0.3	1.3	-0.0	-0.2	0.2	0.3	1.1	0.2
Lung cancer (father)	1.8	2.2	4.8	-2.0	0.4	0.9	0.9	1.5	-2.2
Illnesses of mother	1.3	1.6	4.0	-2.0	1.3	1.3	-0.4	1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.2	0.0	1.2	-1.0	-1.5	-0.2	-1.2
Pulse wave Arterial Stiffness index	1.5	1.7	6.7	-0.7	1.2	0.4	1.1	-0.7	2.6
Impedance of arm (left)	0.2	0.7	3.6	-0.2	0.2	-0.5	0.3	-0.6	-1.9
Arm fat mass (right)	0.1	0.6	2.3	-0.2	-0.3	-1.5	0.8	0.1	-0.7
Trunk predicted mass	0.1	0.5	1.2	1.1	-0.8	0.6	-0.1	-0.9	-0.0
Standing height	0.3	3.3	8.5	1.8	-1.0	0.8	-1.0	-2.9	-2.2
Length of working week for main job	0.2	0.3	0.6	0.3	0.5	0.8	-0.3	-0.6	-0.0
Exposure to tobacco smoke at home	2.5	2.8	9.3	0.6	-2.4	-3.0	-1.0	-0.8	-0.2
Breastfed as a baby	3.0	3.7	11.8	0.0	0.4	-3.4	-1.0	-1.1	2.8
Tense / ‘highly strung’	0.2	0.3	0.5	0.4	-0.1	0.7	-0.5	0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.9	-1.1	0.6	1.1	0.1	1.7	0.6
Hair/balding pattern: Pattern 4	1.0	2.4	9.1	-0.7	0.4	-0.5	-1.0	3.0	1.7
Birth weight of first child	0.4	0.7	2.0	1.1	0.3	-0.5	0.7	-1.4	0.4
Peak expiratory flow (PEF)	0.6	1.5	5.2	-0.4	-0.2	0.4	-2.3	0.4	-1.8
Pulse wave reflection index	1.4	1.7	3.8	-0.2	1.7	1.0	1.2	-1.2	1.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.8	1.7	0.2	0.6	1.3	-0.1	0.8
Loud music exposure frequency	1.1	1.2	5.2	0.1	1.0	-0.7	-0.3	2.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	3.6	1.9	-1.0	-0.4	0.0	-1.6	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.5	-0.6	-0.8	0.8	-0.5	-0.5
Blood clot in the leg (DVT)	1.6	2.1	5.7	1.3	-1.5	-1.0	-0.3	-2.4	-1.3
Medication: Paracetamol	0.6	0.9	3.1	-0.5	-0.6	0.3	-0.6	1.2	1.8
Headache pain in last month	0.4	0.6	1.1	-0.7	-0.5	-0.3	0.9	1.0	1.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	4.0	0.2	-0.6	1.1	-0.0	-0.5	-2.0
Glaucoma (self-reported)	0.7	0.8	2.8	-0.3	-0.2	-0.0	-0.3	-1.7	1.4
Gout (self-reported)	0.5	0.7	2.0	0.4	0.5	-1.4	0.6	-0.6	1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.1	-0.1	-0.8	0.2	-0.6	1.0	0.8
Medication: Amlodipine	2.7	3.8	9.2	0.3	2.7	0.9	2.1	0.8	3.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.0	-0.5	-1.4	0.0	0.7	-0.3	-0.8
Birth weight	0.2	0.5	1.6	0.4	0.6	0.2	-0.0	-1.3	1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.6	0.2	1.2	1.9	0.7	0.7	1.6
High blood pressure (siblings)	0.7	1.0	2.1	-0.7	1.4	-0.1	-0.3	1.5	1.1
Forced vital capacity (FVC), Best measure	0.2	0.7	2.3	0.1	1.5	-0.6	-1.0	-0.7	-0.4
Body fat percentage	0.3	1.2	3.9	-0.7	-0.3	-2.0	0.8	0.2	-1.6
Leg fat percentage (right)	0.4	1.4	4.0	-0.5	-0.4	-1.8	0.9	0.2	-2.0
Arm fat-free mass (right)	0.2	0.8	2.0	1.3	-1.4	-0.3	-0.6	-0.9	-0.1
Exposure to tobacco smoke outside home	1.6	2.2	3.5	1.6	-1.4	-1.9	-1.2	0.7	-1.8
Comparative body size at age 10	0.5	1.3	5.0	1.4	0.0	-0.3	0.7	-2.2	0.7
Number of full brothers	0.2	0.3	0.8	-0.3	-0.5	-0.4	0.9	-0.5	0.5
Worry too long after embarrassment	0.6	0.9	2.1	-1.1	0.4	0.9	0.3	1.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.6	-0.9	0.4	0.1	-1.6	0.9	-0.0
Wheeze or whistling in the chest in last year	0.3	0.6	2.8	0.5	-0.5	0.4	0.3	-0.2	1.7
Number of children fathered	2.1	2.3	4.3	-0.9	0.8	2.1	1.5	2.0	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	4.8	-0.4	0.5	-0.5	-2.2	0.6	0.8
Age at first live birth	1.0	1.9	8.9	0.3	-0.4	-1.0	-0.0	-3.0	1.0
Pulse wave peak to peak time	1.7	2.0	7.2	1.1	-1.2	-0.5	-1.2	0.4	-2.7
Health satisfaction	0.4	0.5	2.4	0.5	0.1	0.3	-0.3	-0.3	1.5
Shortness of breath walking on level ground	0.7	0.9	1.7	1.3	-1.0	0.7	-0.5	-0.7	-1.0
Qualifications: College or University degree	0.8	2.4	4.9	0.8	1.1	-1.1	-1.9	-1.7	2.2
Eye problems/disorders: None of the above	0.6	0.6	2.9	-0.5	-0.1	0.6	1.7	-0.1	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.5	1.3	-0.5	-0.2	-0.4	-1.4	1.9
Emphysema/chronic bronchitis	1.5	1.7	6.4	0.3	-1.0	-2.5	-1.5	-0.5	-0.7
Medication for pain relief, constipation, heartburn	1.0	1.8	4.6	-0.8	1.7	1.1	0.3	1.1	-2.1
Neck or shoulder pain in last month	0.4	0.6	1.2	1.1	-0.8	0.6	-0.7	0.6	-0.5
Medication: Blood pressure	0.4	0.7	1.2	-0.9	0.9	-0.9	0.1	1.0	1.1
Angina (self-reported)	0.4	0.5	1.3	0.5	-0.3	1.1	-0.3	1.2	-0.1
Migraine (self-reported)	1.1	1.4	6.7	-0.4	0.1	0.4	0.5	1.1	2.6
Medication: Ibuprofen	0.8	1.0	2.7	0.7	-1.6	-0.4	0.4	-1.6	-0.5
Medication: Allopurinol	0.8	1.0	2.0	0.6	1.2	-1.4	0.2	-0.6	1.4
Medication: Omeprazole	1.3	1.5	4.2	0.4	-0.5	-0.1	-2.1	-1.9	1.0
Medication: Seretide 50 evohaler	1.8	2.1	5.7	0.5	-2.4	-1.2	-0.1	-2.2	-0.5
Mean time to correctly identify matches	0.5	1.0	3.8	-0.5	0.9	0.8	-0.5	1.9	0.2
Heart disease (mother)	3.7	4.6	13.0	1.5	-2.4	-3.6	-2.3	-0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.8	-0.4	0.5	-0.9	0.2	1.4	-0.2
Whole body fat mass	0.2	0.8	2.0	-0.1	-0.4	-1.4	0.8	-0.2	-1.4
Leg fat mass (right)	0.3	1.1	2.9	0.3	-1.0	-1.7	0.4	-0.3	-1.6
Arm predicted mass (right)	0.1	0.8	2.0	1.1	-1.4	-0.2	-0.7	-0.9	0.0
Pulse rate, automated reading	0.3	1.0	2.3	-1.2	-0.8	1.1	-0.2	0.4	-1.5
Alcohol intake frequency.	0.5	1.1	4.6	-0.2	-0.1	0.9	0.1	2.1	-1.2
Comparative height size at age 10	0.2	1.2	3.1	1.8	-0.8	-0.0	0.5	-1.0	-1.4
Number of full sisters	1.0	1.3	3.0	1.7	-1.5	1.2	0.8	0.3	0.5
Suffer from ‘nerves’	0.2	0.3	0.9	0.4	0.3	1.0	-0.8	0.6	0.0
Overall health rating	0.5	1.1	5.2	-0.4	0.1	0.9	0.8	2.3	-0.1
Chest pain or discomfort	0.3	0.5	0.9	0.9	0.3	-0.6	-0.2	0.9	-0.7
Had major operations	1.1	1.3	3.7	-1.7	-0.6	1.9	-0.7	0.0	-0.7
Age at last live birth	0.4	0.6	2.7	-0.2	-0.4	-0.3	-0.3	-1.6	0.8
Family relationship satisfaction	1.6	2.0	4.6	-1.5	2.1	0.3	-0.6	1.9	1.1
Leg pain on walking	1.1	1.3	2.9	-1.4	0.7	0.8	0.6	1.7	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.2	-0.4	-0.8	0.7	-0.2	-0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.3	6.0	0.9	0.6	-0.4	0.7	-2.4	-0.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	6.9	1.4	-0.9	-1.1	0.4	-2.6	-0.5
Medication: Aspirin	0.7	0.9	2.8	0.2	-0.9	-1.7	-1.0	-0.9	0.6
Supplements: Vitamin C	0.7	0.9	2.1	-0.1	-1.3	-0.6	-0.8	-0.6	1.5
Knee pain experienced in last month	1.0	1.5	6.7	-1.3	0.0	-0.1	0.8	2.6	0.2
Hypertension (Self-reported)	0.5	1.5	5.1	0.6	0.7	-1.2	0.0	1.4	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	3.2	-0.0	0.2	0.4	-1.8	-1.4	-0.1
Illnesses of father: Heart disease	1.0	1.4	3.4	1.8	-0.3	-1.3	-1.7	-0.3	-0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.4	-1.5	-0.2	1.3	0.1	0.6	-1.3
Smoking status: Previous	2.3	3.4	9.1	0.3	-1.7	-2.3	-1.8	0.1	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.4	0.4	-0.1	0.4	1.8	-0.1	0.1
Whole body fat-free mass	0.1	0.5	1.4	1.2	-1.0	-0.1	-0.2	-0.8	0.2
Leg fat-free mass (right)	0.1	0.5	0.8	0.9	-0.9	-0.6	-0.1	-0.4	0.8
Arm fat percentage (left)	0.3	1.2	3.1	-0.7	0.0	-1.8	1.3	0.9	-0.9
Average weekly red wine intake	0.3	0.5	1.4	-0.7	1.2	-0.7	-0.2	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.0	-1.4	1.1	-0.8	0.2	0.2	-1.0
Mood swings	1.0	1.8	7.0	0.0	-0.5	-0.1	-1.8	2.6	-0.8
Loneliness, isolation	1.7	2.3	3.8	2.0	-1.9	-0.5	-0.6	1.9	-1.4
Long-standing illness, disability or infirmity	1.2	1.9	5.1	-2.1	0.2	1.3	0.7	2.2	0.2
Ever had bowel cancer screening	0.9	1.1	3.6	-1.1	-0.6	0.3	0.3	-1.1	-1.9
Diabetes diagnosed by doctor	0.6	1.0	2.3	-1.4	0.1	0.1	0.9	1.0	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	1.1	-0.7	0.1	0.3	-0.6	-0.5
Friendships satisfaction	0.7	0.9	1.9	-0.5	0.5	-1.4	-1.3	1.0	0.2
Qualifications: nursing, teaching	0.8	1.2	3.9	0.1	-1.2	-2.0	-1.0	-0.8	0.3
Commuting to job workplace: Walk	2.2	2.3	5.1	-1.8	-0.4	-0.4	-0.7	2.2	-2.3
Eye problems/disorders: Cataract	0.4	0.4	1.7	0.6	-0.0	-0.2	-0.5	0.2	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	5.3	2.3	-1.9	-1.7	-0.8	-0.5	0.5
Medication for cholesterol	0.6	0.9	2.0	-1.4	-0.0	1.2	0.6	0.2	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	8.7	1.8	-3.0	-0.2	-0.9	-1.5	0.9
Back pain experienced in last month	0.6	0.9	1.6	1.1	-1.2	1.3	-0.5	-0.6	0.1
Mineral and other dietary supplements	0.2	0.3	0.9	-1.0	0.3	0.0	-0.7	-0.2	0.2
Breast cancer (self-reported)	0.3	0.3	1.5	0.1	0.4	-0.5	-0.3	1.2	0.1
Asthma (self-reported)	0.3	0.7	2.0	0.6	-0.5	1.4	0.2	1.2	0.1
Osteoporosis (self-reported)	1.5	1.9	3.3	-1.3	0.9	1.8	1.8	1.4	-0.5
Osteoarthritis (self-reported)	0.6	0.8	4.3	-0.4	0.2	-2.1	0.1	-0.2	-0.2
Medication: Aspirin	0.6	0.8	2.2	0.3	-0.7	-1.5	-0.9	-0.9	0.4
Medication: Gliclazide	0.6	0.7	2.4	0.1	-0.3	-0.5	0.9	-1.6	-0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	-1.1	0.8	1.2	1.2	1.0	-0.3
Smoking status: Current	0.3	0.4	1.2	1.1	-0.0	0.1	0.6	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.6	-0.7	2.4	-0.9	-2.2	0.9	1.1
Whole body water mass	0.1	0.5	1.3	1.1	-1.0	0.0	-0.1	-0.8	0.2
Leg predicted mass (right)	0.1	0.6	1.1	1.1	-0.9	-0.6	-0.2	-0.5	0.8
Arm fat mass (left)	0.1	0.6	1.9	-0.2	-0.1	-1.4	0.9	0.4	-0.9
Number of self-reported non-cancer illnesses	0.8	1.3	6.4	-0.3	0.7	0.9	-0.5	0.1	2.5
Average weekly champagne plus white wine intake	0.6	0.8	1.9	-0.2	0.2	-1.1	-0.1	-1.4	1.3
Miserableness	0.8	1.4	3.6	1.6	-0.9	0.7	-0.7	1.9	-0.5
Guilty feelings	0.1	0.2	0.7	0.8	-0.0	0.5	0.3	0.1	0.5
Wears glasses or contact lenses	0.2	0.2	1.0	-1.0	-0.2	0.4	0.1	0.3	-0.1
Ever taken oral contraceptive pill	0.4	0.5	1.4	-0.9	0.8	0.2	-0.2	1.2	0.3
Hearing aid user	0.8	0.9	2.5	-0.8	-0.5	-1.1	0.1	-0.6	-1.6
Mother’s age at death	0.9	1.2	4.8	-0.6	2.2	0.7	0.7	0.6	0.7
Financial situation satisfaction	0.2	0.2	0.7	-0.3	0.8	-0.3	0.0	0.0	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	1.0	0.1	-0.2	0.1	1.1	1.2
Commuting to job workplace: Public transport	1.4	1.7	5.2	-1.8	1.1	0.7	0.4	2.3	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	0.0	0.0	0.7	0.0	-0.9	0.6
Medication: Blood pressure	0.7	1.3	5.2	1.2	0.0	0.2	-0.6	0.7	2.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.4	-0.1	-0.5	-0.7	0.5	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.9	2.0	-0.2	-0.6	1.6	-0.8	0.4
High cholesterol (Self-reported)	2.8	5.0	17.8	0.7	1.3	-2.1	0.6	-2.3	4.2
Medication: Bendroflumethiazide	0.9	1.3	3.9	0.3	-2.0	-1.1	-0.5	1.5	0.7
Medication: Paracetamol	0.6	0.9	2.7	-1.1	-0.6	0.4	-0.3	1.6	1.0
Medication: Lisinopril	0.3	0.3	1.1	-0.5	-0.6	-0.5	0.4	0.3	-1.0
Medication: Atorvastatin	1.7	2.2	5.2	-0.6	2.2	0.6	1.2	-0.9	2.3
Illnesses of father: High blood pressure	0.4	0.5	1.0	-0.3	0.7	-0.9	-0.2	0.6	1.0
Alcohol drinker status: Never	0.7	0.8	1.8	0.7	-1.3	0.5	-0.8	-0.2	-1.3
Ever smoked	0.5	0.9	1.2	0.9	-1.1	-1.1	0.1	-1.0	-1.1
Basal metabolic rate	0.1	0.5	1.1	1.0	-1.0	-0.4	-0.1	-0.8	-0.2
Leg fat percentage (left)	0.3	1.2	2.9	-0.7	-0.3	-1.7	1.0	0.3	-1.7
Arm fat-free mass (left)	0.1	0.5	1.0	1.0	-0.9	-0.3	-0.5	-0.7	-0.3
Number of operations (self-reported)	0.7	1.0	3.5	-0.6	-1.9	0.5	-1.1	-0.4	0.6
Average weekly beer plus cider intake	0.5	0.8	1.4	-0.6	-0.8	1.1	-0.2	1.2	0.9
Irritability	1.7	2.9	5.1	-1.5	1.8	1.5	2.1	2.3	-0.4
Risk taking	1.2	1.7	3.5	-0.7	1.0	-1.7	-0.7	1.4	-1.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.4	-0.8	0.9	0.1	-0.1	1.2	0.5
Fractured/broken bones in last 5 years	0.9	1.2	2.2	0.9	1.1	0.9	-0.8	1.2	1.5
Age started oral contraceptive pill	0.4	0.5	0.8	-0.5	0.9	0.1	-0.9	0.2	0.9
Diastolic blood pressure, automated reading	0.4	1.3	3.5	0.1	-0.6	-1.9	-0.1	0.8	-1.8
Ever depressed for a whole week	1.0	1.2	2.0	0.5	1.3	-0.1	1.2	1.4	1.3
Unable to work because of sickness or disability	0.6	0.8	2.6	-0.5	-0.6	-1.0	-0.2	1.6	-0.6
Commuting to job workplace: Cycle	0.5	0.7	2.3	0.5	-0.1	0.4	-1.1	1.5	0.2
Myopia	0.2	0.3	0.6	0.2	0.5	0.5	0.0	0.8	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.7	-1.3	-0.2	0.9	0.1	-1.1	-2.2
Cholesterol lowering medication	1.2	1.8	6.7	-0.2	0.7	-1.5	0.7	-0.8	2.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	4.6	-0.3	-0.0	0.5	-1.1	-2.1	1.4
Pain experienced in last month	0.4	0.6	1.5	-0.1	1.2	-0.7	-0.4	-1.2	0.2
Supplements: Calcium	0.2	0.3	1.2	0.4	-0.4	0.0	0.1	-0.1	1.1
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-1.0	0.1	1.2	-1.0	0.4	1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.9	1.4	-0.6	0.9	-0.0	-1.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	5.9	0.8	-1.5	-1.0	-0.1	-2.4	-1.6
Heart disease (siblings)	1.1	1.4	3.5	1.3	-0.1	0.8	0.8	-1.4	1.9
Alcohol drinker status: Previous	2.4	2.7	7.0	-1.1	-1.8	1.3	-0.9	1.5	-2.6
Pack years of smoking	0.6	0.9	2.5	1.6	0.3	0.7	0.5	0.4	-1.4
Impedance of whole body	0.3	1.5	7.7	-0.0	-0.1	-0.1	0.0	-1.2	-2.8
Leg fat mass (left)	0.3	1.0	2.7	0.1	-1.0	-1.6	0.5	-0.3	-1.4
Arm predicted mass (left)	0.1	0.6	1.3	1.1	-0.9	-0.3	-0.7	-0.8	-0.4