Hub : Genes

LAPTM4A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.470	0.0918	1.3e-05	0.362	NA	0.324	NA	0.355	7.2e-14	NA	2.5e-12	NA	1.3e-13
2	GTEx	Pancreas	0.331	0.0820	1.1e-04	0.162	NA	0.108	NA	0.122	2.4e-07	NA	2.7e-05	NA	7.9e-06
3	GTEx	Testis	0.205	0.0770	7.4e-03	0.148	NA	0.072	NA	-0.004	4.3e-07	NA	4.2e-04	NA	5.0e-01
4	TCGA	Skin Cutaneous Melanoma	0.145	0.0810	5.3e-03	0.019	0.065	0.058	NA	0.031	9.7e-02	0.0081	1.2e-02	NA	5.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.8	3.9	1.1	0.4	-1.4	-2.0
Bipolar Disorder or Schizophrenia	1.4	3.4	4.5	1.9	1.5	-2.1	-1.8
Depressed Affect (Nagel 2018)	0.8	1.6	2.4	-0.9	-1.1	-1.4	-1.6
Depression (Nagel 2018)	0.3	0.5	1.2	-0.8	-1.1	0.0	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-0.3	-0.6	-1.0	-0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.4	-0.4	-0.7	-0.6
Schizophrenia (2018)	1.0	2.0	2.8	1.6	1.7	-1.6	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.3	0.8	-0.5	0.6
Worry (Nagel 2018)	0.1	0.2	0.5	-0.7	-0.4	-0.2	-0.0
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	-0.8	-0.8	-0.8	0.1
Alzheimer’s Disease (in father)	1.3	1.4	2.3	-1.1	-1.1	-1.5	-1.0
Alzheimer’s Disease (including proxy)	2.0	2.8	7.6	-1.1	-1.3	-2.8	-0.8
Crohns Disease (2017)	0.7	1.4	3.1	1.8	1.6	0.4	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	0.8	0.6	0.8	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.1	-0.2	-0.4	0.7	-1.1
Major Depression (MDD)	0.7	0.9	2.5	-0.3	-0.5	-1.6	-0.8
Reaction Time	1.9	3.7	5.8	-1.7	-1.5	2.4	2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.3	-0.8	-0.3	-1.0
Breast Cancer	0.3	0.7	1.5	0.1	-0.1	1.2	1.1
Ovarian Cancer	2.9	3.8	5.7	-2.4	-2.4	1.9	0.6
Prostate Cancer	1.1	1.5	4.0	0.5	0.3	-1.3	-2.0
Age at First Birth	0.5	0.7	1.3	-1.2	-0.8	0.3	0.8
Bipolar Disorder (2011)	0.1	0.1	0.5	0.2	-0.2	-0.1	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.2	-0.1	1.0	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.2	0.4	0.1	0.8
Crohns Disease (2012)	3.4	5.5	10.3	3.2	3.2	0.4	1.2
Mean Putamen Volume	0.3	0.3	0.6	-0.6	-0.5	0.8	0.1
Fasting Glucose	1.5	1.7	4.4	-0.9	-0.4	1.3	2.1
HbA1C	0.4	0.5	0.9	0.8	0.9	0.6	-0.0
HDL Cholesterol	0.4	0.7	1.0	0.9	0.8	-1.0	-0.8
LDL Cholesterol	0.9	1.5	2.2	1.1	1.4	-1.5	-0.7
Lupus	0.5	0.7	1.0	0.9	1.0	-0.9	-0.6
Neuroticism (2016)	0.3	0.4	0.8	0.7	0.6	-0.3	-0.9
Primary Biliary Cirrhosis	1.1	1.6	3.5	0.2	1.0	1.3	1.9
Rheumatoid Arthritis	1.0	1.4	3.5	-0.6	-0.6	1.9	1.1
Schizophrenia (2014)	0.8	1.9	2.9	1.5	1.7	-1.3	-0.8
Triglycerides	0.4	0.7	1.1	0.8	0.7	-0.8	-1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.2	0.2	0.8	0.3
Ulcerative Colitis	0.5	0.7	2.5	-0.4	-0.4	1.6	0.0
Blood Eosinophil Count	0.4	3.4	5.5	-1.5	-1.0	2.2	2.4
Blood Platelet Count	0.1	1.5	2.5	1.2	1.1	-1.6	-1.0
Blood Red Count	0.1	1.4	2.4	-1.5	-1.1	-1.0	1.0
Blood White Count	0.1	0.6	2.1	0.3	0.4	-1.4	-0.5
Heel T-Score	0.1	0.8	1.4	0.6	0.9	-1.2	-0.7
BMI	0.5	3.1	7.1	-2.3	-2.7	0.5	0.0
Height	1.7	32.9	62.9	7.9	7.8	-2.2	-1.9
Waist Hip Ratio (WHR)	1.2	5.6	7.5	2.7	2.4	-2.2	-2.1
Systolic Blood Pressure	1.1	5.5	9.8	-3.1	-2.8	1.9	0.8
Smoking Status	0.6	1.5	2.9	1.7	1.7	0.1	-0.2
Allergy or Eczema	0.3	0.8	1.4	1.2	0.8	1.0	0.0
Cardiovascular Disease	0.3	1.0	2.1	-1.4	-1.4	0.0	0.4
Hypothyroidism (self reported)	0.4	0.8	1.0	-0.9	-0.6	-1.0	1.0
Respiratory disease	1.1	2.5	5.7	-0.8	-0.7	1.9	2.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.4	-0.7	0.1	-0.3
Lung FEV1/FVC ratio	1.7	8.6	13.9	2.5	1.9	-3.2	-3.7
Lung FVC	0.5	2.5	4.9	-2.2	-1.9	1.1	-0.3
Neuroticism	0.2	0.4	0.7	-0.6	-0.4	-0.8	-0.7
Chronotype (morning person)	1.0	2.3	6.9	0.4	-0.3	-1.4	-2.6
Hair Pigment	0.2	5.7	12.6	1.7	2.7	0.3	3.5
Tanning	0.0	0.1	0.3	0.2	0.0	0.6	-0.3
Hand grip strength (left)	0.4	1.1	2.2	1.5	1.3	-0.4	-0.5
Number of treatments/medications taken	0.7	1.2	3.6	-0.3	-0.6	-1.9	-1.0
Average weekly spirits intake	0.5	0.6	1.4	-0.7	-0.3	-0.6	1.2
Sensitivity / hurt feelings	0.2	0.4	0.6	0.3	0.7	0.6	0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	-1.1	-1.2	0.4	-0.6
Hearing difficulty/problems: Yes	0.5	0.7	1.1	-0.4	-0.7	1.0	-1.0
Relative age of first facial hair	1.5	3.1	5.8	1.7	1.8	-2.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.1	-0.5	-1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.8	-1.0	0.1	-0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	-0.7	-0.9	1.1	0.4
Systolic blood pressure, automated reading	0.5	1.5	2.7	-1.3	-1.2	1.6	0.4
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	5.0	2.2	2.1	-1.3	-1.0
Angina	0.2	0.2	0.5	-0.1	0.2	0.7	-0.5
Medication for hormone replacement therapy	1.5	1.6	2.6	1.4	1.2	-0.8	-1.6
Vitamin and mineral supplements	0.3	0.3	0.7	0.4	0.4	0.6	0.8
Supplements: Zinc	0.0	0.0	0.2	0.0	-0.1	0.4	0.1
Medication: Co-codamol	0.8	0.9	2.8	-0.8	-0.4	0.3	1.7
Medication: Metformin	0.6	0.8	2.4	0.1	-0.2	-0.9	-1.5
Diabetes (father)	0.6	0.7	1.2	-0.8	-0.5	1.1	0.9
Diabetes (mother)	0.3	0.3	1.3	-0.0	-0.1	-0.2	-1.1
Severe depression (siblings)	0.2	0.2	0.5	-0.7	-0.5	0.0	0.2
Pack years adult smoking proportion	0.4	0.6	1.1	1.0	1.0	0.1	0.6
Impedance of leg (right)	2.3	11.1	23.5	4.3	4.8	0.1	1.5
Leg fat-free mass (left)	0.3	1.5	2.0	-1.0	-1.4	-1.3	-1.2
Trunk fat percentage	0.1	0.4	0.9	-0.0	-0.1	-1.0	0.8
Hand grip strength (right)	0.3	0.9	1.8	1.3	1.3	-0.3	-0.2
Townsend deprivation index at recruitment	1.1	1.5	3.4	0.5	0.1	-1.5	-1.9
Current tobacco smoking	0.3	0.5	0.8	0.9	0.9	-0.5	-0.2
Average weekly fortified wine intake	1.3	1.5	4.7	-0.6	-0.5	2.2	0.9
Maternal smoking around birth	0.9	1.3	2.5	-1.3	-1.6	1.0	0.3
Fed-up feelings	1.0	1.8	4.5	0.2	0.1	-2.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	-0.8	-1.1	0.9	-0.2
Relative age voice broke	0.3	0.4	0.8	0.7	0.5	-0.4	-0.9
Taking other prescription medications	1.8	2.8	5.8	-2.3	-2.4	0.0	0.1
Age when periods started (menarche)	0.6	1.4	2.9	-0.7	-0.3	1.4	1.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.3	-0.0	-0.3	-1.5	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	-0.0	-0.3	-0.8	-0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.0	0.2	0.0	2.0	0.6
Qualifications: CSEs or equivalent	1.2	1.6	5.8	0.4	-0.1	-0.6	-2.4
Serious illness, injury or assault to yourself	0.6	0.7	1.6	0.8	0.7	1.2	-0.2
High blood pressure	1.2	3.4	6.7	-2.6	-2.6	0.1	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.9	0.5	0.8	-0.1
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	0.3	-0.2	0.1
Stomach or abdominal pain in last month	0.8	1.0	2.0	-0.9	-0.9	1.4	0.6
Supplements: Glucosamine	0.5	0.6	1.1	0.8	1.1	-0.8	-0.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.8	1.9	1.5	0.6	-0.5
Medication: Atenolol	0.7	0.9	1.8	-0.9	-1.4	0.3	-1.0
Medication: Levothyroxine sodium	0.6	1.1	1.7	-1.3	-1.1	-0.3	1.1
Sitting height	0.3	2.3	4.1	1.5	1.6	-2.0	-0.6
Chronic bronchitis/emphysema (father)	0.8	1.0	1.6	1.3	1.2	-0.7	0.5
High blood pressure (mother)	2.0	2.8	5.2	-2.1	-2.3	-0.7	-0.9
Body mass index (BMI)	0.9	3.8	8.7	-2.5	-3.0	-0.3	-0.4
Impedance of leg (left)	2.2	10.5	22.0	4.4	4.7	-0.4	0.8
Leg predicted mass (left)	0.3	1.5	1.9	-0.9	-1.4	-1.3	-1.2
Trunk fat mass	0.1	0.4	1.3	-0.1	-0.4	-1.1	0.2
Waist circumference	0.3	1.1	2.0	-0.9	-1.4	-0.9	-0.8
Number of incorrect matches in round	0.3	0.6	0.7	-0.9	-0.9	-0.7	0.6
Past tobacco smoking	0.1	0.2	0.3	-0.4	-0.4	-0.6	0.4
Alcohol usually taken with meals	0.1	0.2	0.3	-0.6	-0.4	0.4	0.6
Nervous feelings	0.5	0.9	1.9	-0.5	-0.3	-1.4	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.2	-1.5	-1.4	-0.2	-0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.2	-0.3	0.1	-0.6
Hair/balding pattern: Pattern 2	1.9	2.4	6.1	0.9	0.9	2.5	1.4
Had menopause	0.1	0.2	0.3	0.5	0.2	-0.4	-0.5
Had other major operations	1.0	1.2	2.5	-1.3	-1.6	0.7	0.3
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.1	0.2	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.4	-0.6	0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.7	-0.7	-0.9	-0.0	0.5
Qualifications: None of the above	0.3	0.6	1.2	-0.8	-1.1	0.4	-0.5
Financial difficulties in last 2 years	0.3	0.5	1.4	-0.1	0.4	0.6	1.2
Mouth/teeth dental problems	1.3	2.1	2.5	-1.5	-1.6	1.5	1.0
Heart attack	0.5	0.7	1.4	0.6	0.6	-1.2	-0.6
Allergy	0.7	1.5	3.0	-0.9	-0.8	-1.7	-1.2
Pain all over the body in last month	1.3	1.4	2.3	-1.4	-1.5	1.1	-0.0
Diabetes (self-reported)	0.1	0.1	0.2	0.5	0.4	-0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.7	0.9	0.5	-0.5	-1.6
Medication: Ramipril	4.1	5.3	7.2	-2.7	-2.4	2.2	1.8
Medication: Simvastatin	2.1	3.1	4.5	2.0	2.1	-1.7	-1.0
Fluid intelligence score	0.2	0.4	1.0	0.4	0.0	-1.0	-0.6
Illnesses of siblings	0.5	0.7	1.3	0.9	1.1	-0.9	0.1
Neuroticism score	0.1	0.2	0.4	-0.1	0.1	-0.7	-0.6
Weight	0.2	0.9	1.7	-0.4	-0.8	-1.3	-1.0
Impedance of arm (right)	1.9	8.7	17.6	3.7	4.2	-1.0	1.6
Arm fat percentage (right)	0.2	0.8	1.7	-1.0	-1.3	-0.5	0.5
Trunk fat-free mass	0.2	0.9	2.5	-0.2	-0.6	-0.8	-1.6
Hip circumference	0.3	1.5	3.2	-1.5	-1.8	-0.1	0.6
Time employed in main current job	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.2
Alcohol intake versus 10 years previously	1.2	1.8	3.7	0.1	-0.2	-1.8	-1.9
Father’s age at death	1.0	1.3	2.6	1.6	1.5	0.4	-0.5
Worrier / anxious feelings	0.3	0.6	1.9	-0.6	-0.5	1.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	5.5	-2.2	-2.3	-0.2	-0.4
Falls in the last year	0.4	0.5	1.8	-0.3	-0.4	1.4	0.2
Hair/balding pattern: Pattern 3	0.2	0.2	0.6	-0.0	0.2	0.8	0.5
Number of live births	0.3	0.4	1.2	0.3	0.5	0.3	1.1
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.0	0.5	0.5	-0.9	-1.4
Pulse rate	0.4	0.6	1.1	0.6	0.2	-1.0	-1.0
Happiness	2.8	3.4	4.6	-2.1	-2.1	1.9	1.0
Noisy workplace	0.2	0.2	0.6	-0.5	-0.4	-0.8	0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.0	0.6	0.7	0.7	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	-0.1	-0.3	0.3
Mouth/teeth dental problems: Dentures	2.1	3.6	5.1	2.3	2.0	-1.5	-1.7
Asthma	1.5	3.0	5.7	-0.7	-0.4	2.4	2.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.9	1.0	-0.1	0.3
Medication: Cholesterol lowering	0.8	1.2	2.6	-0.2	-0.4	-1.6	-1.5
Depression (self-reported)	0.1	0.2	0.4	0.3	0.3	0.6	0.2
Medication: Lansoprazole	1.7	1.9	2.9	1.5	1.6	-1.7	-0.3
Prospective memory result	0.7	0.9	1.7	-1.2	-1.3	-0.1	-0.6
Lung cancer (father)	1.0	1.2	2.6	0.9	1.1	-1.6	-0.4
Illnesses of mother	0.5	0.6	1.1	0.6	0.9	0.6	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.3	0.2	0.2	-1.0	-1.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	0.7	0.3	0.1	-0.1
Impedance of arm (left)	1.7	8.0	15.6	3.4	4.0	-0.5	2.2
Arm fat mass (right)	0.2	1.0	2.2	-1.1	-1.5	-0.7	0.0
Trunk predicted mass	0.2	0.9	2.5	-0.1	-0.6	-0.8	-1.6
Standing height	1.2	11.7	20.8	4.6	4.4	-2.2	-1.3
Length of working week for main job	1.7	1.8	2.6	-1.6	-1.6	-1.4	-0.4
Exposure to tobacco smoke at home	0.3	0.4	1.1	0.4	0.2	-1.0	-0.4
Breastfed as a baby	1.2	1.5	2.3	-1.5	-1.0	0.7	1.5
Tense / ‘highly strung’	0.3	0.5	1.0	0.1	0.1	-0.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.7	-1.7	-1.9	1.5	-0.2
Hair/balding pattern: Pattern 4	1.7	4.1	7.7	-2.8	-2.7	-0.7	-0.8
Birth weight of first child	1.6	2.9	5.8	2.2	2.4	0.8	0.1
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.7	-0.6	0.1	-0.8
Pulse wave reflection index	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.3
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.2
Loud music exposure frequency	2.1	2.3	5.6	1.7	1.0	-0.1	-2.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.6	-0.3	-0.2	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.7	-1.3	-1.0	-0.0	0.9
Blood clot in the leg (DVT)	0.0	0.0	0.2	0.1	-0.1	0.4	-0.1
Medication: Paracetamol	0.7	1.2	2.5	-1.6	-1.3	0.5	0.8
Headache pain in last month	0.7	1.2	1.9	-1.4	-1.2	-0.3	1.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	4.3	1.8	2.1	1.4	1.7
Glaucoma (self-reported)	2.2	2.5	5.1	-1.1	-1.3	2.3	1.5
Gout (self-reported)	0.1	0.1	0.3	0.4	0.2	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.7	2.6	-1.5	-1.3	-1.6	0.0
Medication: Amlodipine	1.2	1.7	3.8	-1.9	-1.8	-0.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	0.6	0.8	0.5	1.3
Birth weight	0.0	0.1	0.2	-0.1	0.3	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.5	0.2	0.4	-0.1
High blood pressure (siblings)	0.6	0.9	1.7	-1.0	-0.9	1.3	0.4
Forced vital capacity (FVC), Best measure	0.0	0.1	0.3	-0.3	-0.1	-0.6	-0.4
Body fat percentage	0.1	0.3	0.9	-0.3	-0.5	-1.0	0.4
Leg fat percentage (right)	0.0	0.1	0.3	-0.2	-0.4	-0.5	0.2
Arm fat-free mass (right)	0.3	1.6	2.9	-0.8	-1.3	-1.0	-1.7
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.4
Comparative body size at age 10	0.1	0.2	0.5	-0.1	-0.3	-0.7	-0.5
Number of full brothers	0.2	0.3	0.7	0.1	0.1	-0.8	-0.6
Worry too long after embarrassment	0.4	0.6	1.9	0.3	0.2	-0.7	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.2	-0.3	0.3	-0.9
Wheeze or whistling in the chest in last year	0.8	1.5	2.0	-1.1	-1.0	1.4	1.3
Number of children fathered	1.2	1.3	3.0	0.0	0.5	1.4	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.8	-0.9	0.4	0.5
Age at first live birth	1.2	2.1	3.8	0.9	1.3	1.9	1.4
Pulse wave peak to peak time	0.1	0.1	0.2	-0.5	-0.1	-0.3	0.1
Health satisfaction	1.3	1.7	2.7	-1.5	-1.6	1.0	0.9
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.2	-0.4	-0.2	0.5
Qualifications: College or University degree	0.2	0.6	1.8	0.2	-0.3	-1.3	-0.8
Eye problems/disorders: None of the above	0.6	0.7	2.2	-0.5	-0.3	-1.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.3	-0.2	-0.0	-0.5
Emphysema/chronic bronchitis	0.2	0.3	0.5	0.7	0.6	-0.0	0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	1.3	0.9	0.1	-0.5
Neck or shoulder pain in last month	1.9	2.8	6.1	1.0	0.8	-2.5	-1.8
Medication: Blood pressure	2.2	3.9	8.2	-2.6	-2.9	-0.6	-0.7
Angina (self-reported)	0.2	0.2	0.4	0.1	0.3	0.7	-0.5
Migraine (self-reported)	1.0	1.3	2.5	-1.6	-1.4	0.8	0.1
Medication: Ibuprofen	0.4	0.4	0.7	0.6	0.8	0.2	0.8
Medication: Allopurinol	1.5	1.9	2.8	-1.4	-1.6	1.7	0.7
Medication: Omeprazole	1.7	2.1	3.5	-1.7	-1.9	1.3	0.3
Medication: Seretide 50 evohaler	1.1	1.2	2.5	-0.6	-0.6	1.3	1.6
Mean time to correctly identify matches	2.9	5.4	8.2	-2.1	-1.7	2.9	2.5
Heart disease (mother)	0.8	1.0	3.2	0.4	-0.1	-0.9	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.1	-1.4	-1.5	0.7	0.1
Whole body fat mass	0.1	0.5	1.2	-0.4	-0.8	-1.1	-0.0
Leg fat mass (right)	0.2	0.6	1.0	-0.6	-1.0	-0.9	-0.4
Arm predicted mass (right)	0.3	1.7	2.4	-1.0	-1.5	-1.0	-1.5
Pulse rate, automated reading	0.4	1.2	3.4	0.3	-0.2	-1.1	-1.9
Alcohol intake frequency.	1.3	2.9	5.2	1.2	0.9	-2.3	-2.0
Comparative height size at age 10	0.5	2.9	4.3	2.1	1.7	-1.7	-1.3
Number of full sisters	1.1	1.4	3.0	-0.8	-0.8	1.7	1.1
Suffer from ‘nerves’	0.1	0.2	0.4	-0.3	-0.2	-0.5	-0.7
Overall health rating	0.5	1.0	1.7	-1.2	-1.3	-0.7	-0.3
Chest pain or discomfort	0.2	0.3	0.6	-0.6	-0.5	-0.0	0.7
Had major operations	0.7	0.8	2.1	0.7	0.5	1.4	0.7
Age at last live birth	0.5	0.7	2.6	0.3	0.3	1.6	0.2
Family relationship satisfaction	0.6	0.8	1.3	-0.7	-0.8	1.1	-0.7
Leg pain on walking	1.1	1.4	1.9	-1.2	-1.3	1.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.1	1.0	1.0	-1.5	-1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.0	0.6	0.7	1.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	0.8	1.0	0.2	1.0
Medication: Aspirin	0.8	1.1	3.4	-0.5	-0.5	-1.8	-0.7
Supplements: Vitamin C	2.4	2.8	6.0	-2.1	-2.5	-0.2	-1.0
Knee pain experienced in last month	0.5	0.8	1.7	-1.1	-1.3	0.5	-0.3
Hypertension (Self-reported)	1.2	3.4	6.7	-2.6	-2.6	-0.2	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	-0.5	-0.7	0.4	-0.7
Illnesses of father: Heart disease	1.8	2.6	5.3	-2.2	-2.3	0.2	0.0
Illnesses of siblings: Diabetes	0.3	0.3	0.8	0.7	0.9	0.0	0.2
Smoking status: Previous	0.1	0.1	0.3	0.4	0.5	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.2	1.5	1.3	-1.4	-1.0
Whole body fat-free mass	0.2	1.4	2.7	-0.5	-1.0	-1.2	-1.6
Leg fat-free mass (right)	0.4	2.0	2.6	-1.1	-1.6	-1.4	-1.5
Arm fat percentage (left)	0.2	0.8	1.7	-1.0	-1.3	-0.5	0.6
Average weekly red wine intake	3.7	5.5	10.9	-1.7	-1.3	3.3	2.6
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.2	-0.3	0.6	-0.9
Mood swings	1.2	2.1	3.8	-1.8	-1.9	-0.6	-0.9
Loneliness, isolation	1.9	2.7	8.7	0.0	-0.6	-1.2	-3.0
Long-standing illness, disability or infirmity	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1
Ever had bowel cancer screening	2.6	3.0	6.1	2.2	2.5	0.6	0.9
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.7	0.5	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.9	0.3	-0.1	-0.3	-1.4
Friendships satisfaction	0.8	1.0	1.5	-1.1	-1.1	1.2	0.1
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	-0.3	0.0	0.4
Commuting to job workplace: Walk	1.8	1.9	3.0	-1.6	-1.4	-0.1	1.7
Eye problems/disorders: Cataract	0.6	0.7	1.0	1.0	0.9	0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.3	0.8	0.3	-0.7	-1.8
Medication for cholesterol	0.5	0.8	1.2	-1.0	-1.1	1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	-0.0	-0.2	-0.5
Back pain experienced in last month	0.2	0.3	0.6	0.4	0.8	0.2	0.5
Mineral and other dietary supplements	0.5	0.7	1.1	-0.6	-0.9	-0.6	-1.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	-0.2	0.5	-0.2
Asthma (self-reported)	1.3	2.5	4.8	-0.6	-0.3	2.2	2.2
Osteoporosis (self-reported)	0.7	0.8	1.3	0.6	0.7	1.1	1.1
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.3	-0.3	0.6	0.7
Medication: Aspirin	1.0	1.3	4.3	0.0	-0.0	-2.1	-1.0
Medication: Gliclazide	0.1	0.2	0.6	0.0	-0.1	0.8	0.1
Illnesses of father: None of the above (group 1)	1.3	1.6	2.6	1.6	1.5	-0.8	-1.0
Smoking status: Current	0.3	0.5	1.0	1.0	0.9	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.4	9.4	18.2	-4.3	-4.1	1.5	0.2
Whole body water mass	0.2	1.4	2.4	-0.6	-1.1	-1.2	-1.6
Leg predicted mass (right)	0.4	2.0	2.5	-1.1	-1.6	-1.5	-1.5
Arm fat mass (left)	0.3	1.0	2.3	-1.2	-1.5	-0.6	0.2
Number of self-reported non-cancer illnesses	2.4	4.1	6.6	-1.9	-2.6	-1.0	-2.3
Average weekly champagne plus white wine intake	0.5	0.7	1.3	0.0	0.2	1.2	1.1
Miserableness	0.1	0.2	0.3	-0.3	-0.5	-0.4	-0.6
Guilty feelings	0.0	0.0	0.1	0.0	0.0	-0.2	-0.2
Wears glasses or contact lenses	0.2	0.2	0.4	0.5	0.3	-0.7	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.3	0.3	-0.3	0.0
Hearing aid user	1.8	2.1	3.5	1.7	1.9	1.0	1.1
Mother’s age at death	0.4	0.5	0.8	-0.6	-0.4	0.9	0.7
Financial situation satisfaction	1.0	1.2	3.6	0.3	0.8	0.7	1.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.1	0.2	0.1	-0.8	-1.8
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.8	0.8	0.2	0.5
Eye problems/disorders: Glaucoma	1.8	2.1	4.4	-0.3	-0.4	2.1	2.0
Medication: Blood pressure	0.4	0.8	1.6	-1.2	-1.2	-0.1	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.5	-0.6	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	0.0	0.3	1.5	1.6
High cholesterol (Self-reported)	2.2	4.0	4.8	2.2	2.0	-2.1	-1.5
Medication: Bendroflumethiazide	1.8	2.8	5.6	-2.4	-2.4	-0.1	0.0
Medication: Paracetamol	1.0	1.6	2.7	-1.6	-1.2	0.6	1.4
Medication: Lisinopril	1.3	1.7	4.2	0.7	0.7	-2.0	-1.2
Medication: Atorvastatin	0.4	0.5	1.6	0.3	0.2	-1.2	-0.4
Illnesses of father: High blood pressure	2.1	2.7	3.9	-1.6	-1.4	2.0	1.5
Alcohol drinker status: Never	0.3	0.4	0.5	0.7	0.6	-0.6	0.3
Ever smoked	0.2	0.3	0.4	0.7	0.5	0.5	-0.6
Basal metabolic rate	0.2	1.1	1.7	-0.5	-1.0	-1.2	-1.3
Leg fat percentage (left)	0.1	0.3	0.7	-0.1	-0.5	-0.8	-0.3
Arm fat-free mass (left)	0.2	0.9	1.8	-0.3	-0.8	-0.9	-1.3
Number of operations (self-reported)	0.5	0.7	1.5	-0.7	-1.0	1.2	0.2
Average weekly beer plus cider intake	2.7	3.9	7.3	-2.4	-2.7	-0.2	-1.5
Irritability	0.1	0.2	0.3	0.5	0.5	-0.2	-0.2
Risk taking	0.9	1.3	2.6	1.1	1.0	-0.6	-1.6
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.2	-1.5	-1.4	0.3	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.7	-0.7	0.9	0.4
Age started oral contraceptive pill	0.4	0.5	1.0	1.0	1.0	-0.1	-0.2
Diastolic blood pressure, automated reading	0.6	1.9	3.4	-1.8	-1.9	-0.2	-0.8
Ever depressed for a whole week	0.5	0.7	1.2	-0.4	-0.5	1.0	1.1
Unable to work because of sickness or disability	0.7	0.9	1.1	-0.8	-1.0	-0.9	-1.0
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.4	-0.7	-0.5	-1.2
Myopia	0.7	1.0	2.4	0.9	0.8	-0.6	-1.6
Vascular/heart problems diagnosed by doctor	1.3	3.6	7.5	2.7	2.6	0.1	-0.3
Cholesterol lowering medication	2.0	2.9	4.5	1.9	1.9	-2.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.2	-1.1	-1.3	1.8	0.7
Pain experienced in last month	0.3	0.6	0.9	0.9	0.6	-0.5	-0.9
Supplements: Calcium	0.1	0.1	0.2	0.0	-0.3	-0.4	-0.5
Basal cell carcinoma (self-reported)	3.6	4.3	5.7	-2.3	-2.1	2.4	1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	0.6	0.6	-1.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.2	0.0	0.4	0.0
Heart disease (siblings)	0.1	0.1	0.3	0.3	0.0	0.0	-0.5
Alcohol drinker status: Previous	1.0	1.1	1.5	1.2	1.0	-1.0	-0.9
Pack years of smoking	0.4	0.6	0.9	0.9	0.9	0.1	0.7
Impedance of whole body	2.4	12.0	24.8	4.4	5.0	-0.7	1.8
Leg fat mass (left)	0.2	0.8	1.3	-0.6	-1.1	-1.0	-0.7
Arm predicted mass (left)	0.2	0.9	1.6	-0.5	-0.9	-1.0	-1.3