Hub : Genes

SDC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.096 0.035 3.0e-03 -0.003 NA -0.001 NA -0.002 7.6e-01 NA 4.4e-01 NA 5.9e-01
2 GTEx Adrenal Gland 0.383 0.082 5.6e-06 0.425 NA 0.367 NA 0.415 1.1e-16 NA 4.4e-14 NA 3.3e-16
3 GTEx Esophagus Mucosa 0.134 0.051 6.6e-03 -0.003 NA -0.003 NA -0.004 6.2e-01 NA 6.4e-01 NA 8.1e-01
4 TCGA Colon Adenocarcinoma 0.095 0.039 6.4e-05 0.004 0.043 0.005 NA 0.007 1.7e-01 0.0017 1.6e-01 NA 1.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.8 0.2 -0.9 0.0 -0.5
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 -0.8 -0.6 0.0 -0.1
Depressed Affect (Nagel 2018) 0.4 0.8 2.2 -0.9 -1.5 0.0 0.3
Depression (Nagel 2018) 0.7 1.0 2.0 -1.2 -1.4 0.0 -0.7
Intelligence (Savage-Jansen 2018) 0.4 1.3 1.9 -1.2 -1.4 0.0 1.4
Neuroticism (Nagel 2018) 0.1 0.3 0.7 -0.8 -0.7 0.0 0.1
Schizophrenia (2018) 0.3 0.5 2.0 -1.4 -0.1 0.0 0.3
Schizophrenia vs Biploar Disorder 1.0 1.3 4.0 -2.0 0.3 0.0 1.2
Worry (Nagel 2018) 0.1 0.2 0.6 0.3 0.0 0.0 -0.8
Alzheimer’s Disease (in mother) 0.4 0.4 1.0 1.0 0.8 0.0 0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.0 -1.0 0.7 0.0 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 1.9 0.2 1.4 0.0 0.6
Crohns Disease (2017) 0.2 0.5 1.9 1.4 0.0 0.0 -0.3
Irritable Bowel Disease (IBD) 0.3 0.8 1.6 1.1 1.3 0.0 -0.6
Ulcerative Colitis (UC) 0.4 0.7 2.2 0.6 1.5 0.0 -0.4
Major Depression (MDD) 2.7 3.3 6.6 -1.7 -2.6 0.0 1.9
Reaction Time 0.0 0.0 0.0 0.1 0.1 0.0 0.0
Verbal and Numeric Reasoning (VNR) 0.9 2.1 4.8 -1.4 -1.3 0.0 2.2
Breast Cancer 0.2 0.4 1.4 1.2 0.1 0.0 -0.3
Ovarian Cancer 0.2 0.2 0.7 0.8 -0.5 0.0 -0.3
Prostate Cancer 0.2 0.3 0.8 -0.9 -0.1 0.0 -0.5
Age at First Birth 0.3 0.5 1.6 1.3 0.1 0.0 0.5
Bipolar Disorder (2011) 0.7 0.7 1.5 -0.5 -1.0 0.0 -1.2
Body Mass Index (BMI) (2010) 0.8 1.1 4.2 0.2 -0.4 0.0 -2.0
Coronary Artery Disease (CAD) 0.0 0.0 0.1 -0.1 0.3 0.0 -0.2
Crohns Disease (2012) 0.2 0.4 1.1 0.6 -0.2 0.0 1.0
Mean Putamen Volume 0.3 0.4 1.1 1.1 0.6 0.0 0.3
Fasting Glucose 1.7 2.1 7.0 -0.1 -1.2 0.0 -2.6
HbA1C 1.0 1.2 3.5 -0.8 -0.7 0.0 1.9
HDL Cholesterol 2.6 4.3 7.8 1.8 2.8 0.0 2.5
LDL Cholesterol 2.0 3.2 6.4 -0.3 2.5 0.0 2.5
Lupus 1.2 1.8 6.1 -0.8 -2.5 0.0 0.8
Neuroticism (2016) 0.0 0.0 0.1 0.1 -0.3 0.0 -0.2
Primary Biliary Cirrhosis 0.4 0.6 1.1 0.4 1.1 0.0 -1.0
Rheumatoid Arthritis 0.1 0.2 0.5 -0.7 0.1 0.0 0.5
Schizophrenia (2014) 0.3 0.6 1.7 -1.3 -0.9 0.0 -0.1
Triglycerides 1.6 2.7 5.1 -2.2 0.8 0.0 2.3
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.4 0.5 0.0 -0.2
Ulcerative Colitis 0.0 0.1 0.1 0.3 0.1 0.0 -0.3
Blood Eosinophil Count 0.2 1.5 3.5 0.6 -1.5 0.0 -1.9
Blood Platelet Count 0.2 2.9 11.4 -0.3 -0.1 0.0 3.4
Blood Red Count 0.5 4.9 12.8 2.0 3.6 0.0 -1.6
Blood White Count 0.1 0.7 2.2 -0.3 -1.5 0.0 -0.7
Heel T-Score 0.2 1.2 4.3 -0.4 0.7 0.0 -2.1
BMI 0.1 0.5 1.5 -0.7 -1.2 0.0 0.4
Height 0.7 13.1 32.8 3.6 2.5 0.0 -5.7
Waist Hip Ratio (WHR) 0.7 3.1 6.8 -2.6 1.7 0.0 1.6
Systolic Blood Pressure 0.1 0.6 1.5 -1.2 -1.0 0.0 0.2
Smoking Status 0.4 0.9 2.2 0.9 -0.7 0.0 -1.5
Allergy or Eczema 0.9 2.4 4.4 -0.9 -2.1 0.0 2.0
Cardiovascular Disease 0.3 0.8 2.5 -0.4 0.9 0.0 1.6
Hypothyroidism (self reported) 0.2 0.4 1.0 -0.7 -1.0 0.0 0.4
Respiratory disease 0.4 1.0 3.4 0.6 -0.3 0.0 -1.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.9 1.4 -0.1 0.0 -0.5
Lung FEV1/FVC ratio 0.5 2.4 5.8 -1.8 0.8 0.0 2.4
Lung FVC 0.9 4.5 17.9 -0.1 0.1 0.0 4.2
Neuroticism 0.2 0.4 1.3 -0.3 -1.1 0.0 -0.6
Chronotype (morning person) 0.4 0.9 2.1 1.1 -0.5 0.0 1.5
Hair Pigment 0.5 13.4 40.2 3.4 6.3 0.0 -1.3
Tanning 0.1 1.1 4.3 -0.0 -2.1 0.0 -0.3
Hand grip strength (left) 0.5 1.4 3.5 1.4 1.9 0.0 0.3
Number of treatments/medications taken 0.5 0.9 3.6 -1.9 0.1 0.0 -0.1
Average weekly spirits intake 0.4 0.5 1.2 0.8 1.1 0.0 -0.1
Sensitivity / hurt feelings 1.4 2.4 4.6 1.3 1.8 0.0 -2.1
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.4 -1.6 -1.1 0.0 -0.6
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.1 0.4 0.0 -0.5
Relative age of first facial hair 1.2 2.5 5.1 0.2 2.2 0.0 -2.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.4 -0.2 -0.1 0.0 1.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.9 0.5 -0.1 0.0 1.7
Ever had hysterectomy (womb removed) 1.9 2.2 6.3 2.5 -1.0 0.0 -1.1
Systolic blood pressure, automated reading 0.2 0.7 1.8 -0.8 0.4 0.0 1.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.7 -0.1 0.9 0.0 0.2
Angina 0.9 1.2 3.4 -0.5 1.0 0.0 1.9
Medication for hormone replacement therapy 0.6 0.6 1.2 0.6 -1.0 0.0 1.1
Vitamin and mineral supplements 0.4 0.5 1.1 0.9 0.1 0.0 -1.1
Supplements: Zinc 0.4 0.5 1.8 1.4 -0.1 0.0 0.2
Medication: Co-codamol 0.7 0.8 2.6 -0.7 0.0 0.0 -1.6
Medication: Metformin 0.4 0.6 1.0 -0.8 -0.8 0.0 1.0
Diabetes (father) 1.1 1.4 3.9 2.0 -1.3 0.0 -0.1
Diabetes (mother) 1.3 1.7 3.3 -1.8 -1.3 0.0 -1.4
Severe depression (siblings) 0.3 0.3 1.1 -1.1 0.3 0.0 -0.3
Pack years adult smoking proportion 0.5 0.8 1.2 1.1 1.1 0.0 -0.9
Impedance of leg (right) 0.4 1.9 5.7 1.4 2.4 0.0 0.2
Leg fat-free mass (left) 0.2 1.2 3.1 -0.2 -1.3 0.0 -1.8
Trunk fat percentage 0.3 1.0 2.4 0.9 0.9 0.0 -1.6
Hand grip strength (right) 0.6 1.5 3.3 1.8 1.6 0.0 0.1
Townsend deprivation index at recruitment 1.4 1.9 5.5 -1.4 -2.3 0.0 -0.6
Current tobacco smoking 0.4 0.6 1.2 -0.1 -1.1 0.0 -1.1
Average weekly fortified wine intake 0.1 0.1 0.2 -0.3 -0.5 0.0 -0.2
Maternal smoking around birth 1.3 1.9 4.1 -0.4 -1.8 0.0 -2.0
Fed-up feelings 0.1 0.1 0.4 -0.6 -0.3 0.0 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.4 -1.2 -0.8 0.0 -0.5
Relative age voice broke 0.1 0.2 0.4 0.4 -0.6 0.0 0.5
Taking other prescription medications 1.5 2.3 3.9 -2.0 -1.4 0.0 -1.9
Age when periods started (menarche) 0.4 0.9 2.3 1.5 0.6 0.0 -1.0
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 5.5 2.3 0.3 0.0 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.8 -1.2 0.5 0.0 -1.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 -0.2 -0.5 0.0 -1.1
Qualifications: CSEs or equivalent 1.1 1.4 2.6 -0.7 -1.6 0.0 1.6
Serious illness, injury or assault to yourself 1.5 1.8 4.0 -1.2 -1.3 0.0 2.0
High blood pressure 0.5 1.4 2.9 -1.6 -1.7 0.0 0.5
Hayfever, allergic rhinitis or eczema 1.0 2.1 6.5 -1.0 -2.5 0.0 1.0
Multivitamins +/- minerals 0.6 0.7 2.6 -1.6 -0.2 0.0 0.5
Stomach or abdominal pain in last month 0.1 0.1 0.3 -0.3 0.5 0.0 -0.5
Supplements: Glucosamine 1.4 1.9 3.2 1.4 1.8 0.0 -1.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 0.8 -0.2 0.0 -0.5
Medication: Atenolol 0.1 0.1 0.3 -0.6 -0.4 0.0 0.0
Medication: Levothyroxine sodium 0.4 0.6 1.0 -1.0 -0.8 0.0 -0.9
Sitting height 0.2 1.5 5.9 2.4 -0.0 0.0 -0.3
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 0.6 0.7 0.0 0.8
High blood pressure (mother) 0.8 1.2 2.5 0.6 -1.3 0.0 1.6
Body mass index (BMI) 0.1 0.4 1.2 -1.1 -0.6 0.0 0.0
Impedance of leg (left) 0.5 2.3 7.1 1.4 2.7 0.0 0.2
Leg predicted mass (left) 0.2 1.3 3.4 -0.2 -1.3 0.0 -1.8
Trunk fat mass 0.2 1.0 3.3 0.7 0.6 0.0 -1.8
Waist circumference 0.1 0.4 1.0 -1.0 -0.5 0.0 -0.7
Number of incorrect matches in round 0.2 0.4 1.0 0.0 -0.8 0.0 -1.0
Past tobacco smoking 0.4 0.7 2.2 -0.4 1.5 0.0 0.6
Alcohol usually taken with meals 0.6 1.0 3.5 1.9 0.5 0.0 -0.1
Nervous feelings 0.1 0.2 0.6 0.8 0.1 0.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.7 0.2 -0.9 0.0 0.3
Hearing difficulty/problems with background noise 0.5 0.7 1.8 1.4 0.5 0.0 0.9
Hair/balding pattern: Pattern 2 0.8 1.0 2.5 -0.1 1.3 0.0 -1.6
Had menopause 0.3 0.4 0.9 0.3 -0.8 0.0 1.0
Had other major operations 1.0 1.2 4.6 0.2 -2.1 0.0 0.5
Forced vital capacity (FVC) 0.1 0.3 1.2 1.1 0.1 0.0 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.4 -1.3 0.6 0.0 -1.8
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 4.3 0.2 -2.1 0.0 -0.9
Qualifications: None of the above 0.6 1.3 4.8 -0.6 -0.1 0.0 -2.2
Financial difficulties in last 2 years 1.9 2.6 6.5 -0.5 -2.6 0.0 -1.9
Mouth/teeth dental problems 0.3 0.5 1.5 0.0 0.6 0.0 -1.2
Heart attack 1.1 1.4 2.8 0.8 1.5 0.0 1.7
Allergy 0.3 0.7 2.3 0.0 1.5 0.0 0.6
Pain all over the body in last month 1.4 1.5 2.9 -1.5 1.7 0.0 -0.9
Diabetes (self-reported) 0.1 0.2 0.6 0.7 0.1 0.0 0.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.8 -1.7 0.3 0.0 0.3
Medication: Ramipril 1.4 1.8 6.2 -0.9 -2.5 0.0 0.1
Medication: Simvastatin 2.1 3.1 4.5 -1.9 2.0 0.0 2.1
Fluid intelligence score 0.8 1.6 5.0 -0.8 -0.8 0.0 2.2
Illnesses of siblings 0.3 0.4 1.4 1.2 0.3 0.0 -0.4
Neuroticism score 0.0 0.0 0.1 0.0 -0.3 0.0 -0.1
Weight 0.2 0.8 3.1 -0.0 -0.1 0.0 -1.8
Impedance of arm (right) 0.4 1.7 3.6 1.9 0.7 0.0 -1.7
Arm fat percentage (right) 0.1 0.3 0.9 -0.6 -0.2 0.0 -1.0
Trunk fat-free mass 0.1 0.8 2.6 -0.8 -0.5 0.0 -1.6
Hip circumference 0.4 1.6 6.0 0.3 -0.6 0.0 -2.5
Time employed in main current job 0.3 0.3 1.0 -0.0 0.5 0.0 1.0
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.5 -0.1 0.0 0.5
Father’s age at death 0.2 0.2 0.8 -0.3 0.1 0.0 -0.9
Worrier / anxious feelings 0.2 0.4 0.7 0.9 0.8 0.0 -0.3
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 6.0 -0.5 -2.4 0.0 0.5
Falls in the last year 1.3 1.8 6.4 -2.5 -0.9 0.0 -0.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 -0.8 0.1 0.0 0.6
Number of live births 0.1 0.1 0.3 -0.5 -0.0 0.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.5 0.5 0.9 0.0 1.2
Pulse rate 0.0 0.0 0.1 0.3 -0.0 0.0 0.1
Happiness 1.5 1.8 5.5 -0.6 -2.4 0.0 -1.2
Noisy workplace 0.6 0.7 2.4 0.7 -0.2 0.0 -1.5
Qualifications: A levels/AS levels or equivalent 0.7 1.6 4.8 0.7 1.0 0.0 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.2 -0.9 -1.5 0.0 1.0
Mouth/teeth dental problems: Dentures 0.3 0.5 0.9 -0.8 0.8 0.0 0.9
Asthma 0.3 0.6 1.5 0.9 -0.6 0.0 -1.2
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.3 -1.4 -0.5 0.0 -1.8
Medication: Cholesterol lowering 2.2 3.5 9.7 -1.4 1.5 0.0 3.1
Depression (self-reported) 0.1 0.1 0.5 -0.3 0.1 0.0 -0.7
Medication: Lansoprazole 1.4 1.6 3.7 0.6 1.5 0.0 1.9
Prospective memory result 0.1 0.1 0.4 -0.4 -0.6 0.0 -0.0
Lung cancer (father) 0.7 0.8 1.4 -1.2 1.1 0.0 -0.8
Illnesses of mother 0.3 0.3 1.0 -1.0 -0.2 0.0 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.0 -0.4 0.8 0.0 1.7
Pulse wave Arterial Stiffness index 1.4 1.6 4.9 -2.2 -0.6 0.0 -1.1
Impedance of arm (left) 0.5 2.3 4.7 2.2 1.2 0.0 -1.8
Arm fat mass (right) 0.1 0.4 1.5 -0.4 -0.1 0.0 -1.2
Trunk predicted mass 0.1 0.9 2.4 -0.8 -0.5 0.0 -1.6
Standing height 0.6 5.5 16.2 2.3 0.9 0.0 -4.0
Length of working week for main job 0.1 0.1 0.3 0.3 -0.5 0.0 0.2
Exposure to tobacco smoke at home 0.6 0.7 2.6 -0.1 -0.5 0.0 -1.6
Breastfed as a baby 1.1 1.4 5.1 0.4 0.5 0.0 -2.3
Tense / ‘highly strung’ 0.1 0.2 0.7 -0.1 0.2 0.0 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.5 5.9 -1.6 -2.4 0.0 -1.3
Hair/balding pattern: Pattern 4 1.7 4.2 16.5 0.2 -4.1 0.0 0.4
Birth weight of first child 0.5 0.9 2.8 0.8 0.5 0.0 1.7
Peak expiratory flow (PEF) 0.4 1.0 2.7 1.0 0.2 0.0 1.7
Pulse wave reflection index 0.7 0.9 2.2 -1.5 -1.0 0.0 -0.7
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.6 -0.9 -0.7 0.0 -1.3
Loud music exposure frequency 2.9 3.2 7.8 -2.8 -1.4 0.0 -1.7
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.5 0.9 1.4 0.0 -1.6
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 2.2 0.5 -1.5 0.0 0.6
Blood clot in the leg (DVT) 1.1 1.5 2.9 -1.7 0.6 0.0 -1.6
Medication: Paracetamol 0.7 1.1 2.5 -0.8 -1.6 0.0 -1.2
Headache pain in last month 1.1 1.8 7.2 0.3 -2.7 0.0 0.1
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 3.2 1.8 -0.9 0.0 -1.2
Glaucoma (self-reported) 1.0 1.1 2.8 -0.8 1.0 0.0 -1.7
Gout (self-reported) 0.4 0.6 1.1 -0.6 -1.0 0.0 1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.1 -0.9 -1.4 0.0 0.3
Medication: Amlodipine 1.1 1.5 3.1 -1.8 -1.7 0.0 -0.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.6 1.2 -0.1 0.0 0.2
Birth weight 0.9 1.9 7.2 -0.3 -0.6 0.0 2.7
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.6 0.1 -1.2 0.0 0.4
High blood pressure (siblings) 0.3 0.4 1.3 0.5 -0.1 0.0 1.1
Forced vital capacity (FVC), Best measure 0.1 0.3 0.7 0.1 0.6 0.0 0.8
Body fat percentage 0.1 0.5 1.0 0.4 0.9 0.0 -1.0
Leg fat percentage (right) 0.1 0.3 1.1 -0.2 1.1 0.0 0.1
Arm fat-free mass (right) 0.1 0.3 0.8 -0.3 -0.4 0.0 -0.9
Exposure to tobacco smoke outside home 0.7 0.9 1.8 1.3 -0.7 0.0 -1.2
Comparative body size at age 10 0.4 1.0 1.9 -0.7 1.4 0.0 1.3
Number of full brothers 0.4 0.5 1.0 -0.5 -1.0 0.0 0.8
Worry too long after embarrassment 0.7 1.2 2.7 -1.2 -1.6 0.0 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 3.1 -1.5 -1.8 0.0 -1.6
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 0.4 -0.5 0.0 -1.1
Number of children fathered 0.5 0.6 2.0 1.4 0.5 0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.8 -0.9 0.5 0.0 0.4
Age at first live birth 0.3 0.5 1.4 -0.4 1.2 0.0 -0.7
Pulse wave peak to peak time 1.3 1.5 5.2 2.3 0.7 0.0 0.7
Health satisfaction 0.6 0.8 2.9 -0.6 -1.7 0.0 -0.0
Shortness of breath walking on level ground 0.1 0.1 0.3 0.5 -0.3 0.0 -0.1
Qualifications: College or University degree 0.4 1.4 3.0 -1.5 -0.6 0.0 1.7
Eye problems/disorders: None of the above 0.2 0.2 0.7 0.2 -0.1 0.0 0.8
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.0 1.0 -0.2 0.0 -1.0
Emphysema/chronic bronchitis 1.1 1.2 2.2 1.5 1.5 0.0 -0.6
Medication for pain relief, constipation, heartburn 0.7 1.2 2.1 1.5 1.0 0.0 1.2
Neck or shoulder pain in last month 1.3 1.9 4.5 -0.5 -1.7 0.0 2.1
Medication: Blood pressure 0.5 1.0 3.0 -1.7 -0.7 0.0 -0.5
Angina (self-reported) 0.9 1.1 3.5 -0.4 0.9 0.0 1.9
Migraine (self-reported) 1.6 2.0 5.4 -0.3 -1.6 0.0 -2.3
Medication: Ibuprofen 0.7 0.9 1.8 -1.4 -0.6 0.0 -1.1
Medication: Allopurinol 0.7 0.9 2.2 0.2 -1.5 0.0 -1.1
Medication: Omeprazole 0.7 0.8 1.8 -1.3 0.0 0.0 -1.3
Medication: Seretide 50 evohaler 0.4 0.5 1.6 1.3 -0.4 0.0 -0.2
Mean time to correctly identify matches 0.1 0.1 0.3 0.5 0.0 0.0 -0.5
Heart disease (mother) 1.0 1.2 3.2 -1.8 0.8 0.0 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.4 0.6 -0.8 0.0 -1.2
Whole body fat mass 0.1 0.5 1.5 0.4 0.5 0.0 -1.2
Leg fat mass (right) 0.1 0.2 0.7 -0.0 0.4 0.0 -0.8
Arm predicted mass (right) 0.1 0.4 1.3 -0.3 -0.6 0.0 -1.1
Pulse rate, automated reading 0.3 0.9 2.8 -0.5 0.8 0.0 1.7
Alcohol intake frequency. 0.6 1.4 5.7 -2.4 0.1 0.0 0.2
Comparative height size at age 10 0.5 2.8 8.0 1.1 -1.5 0.0 -2.8
Number of full sisters 0.8 0.9 2.4 -0.3 -1.1 0.0 -1.5
Suffer from ‘nerves’ 0.3 0.4 1.1 -0.2 -1.1 0.0 -0.7
Overall health rating 0.2 0.3 0.8 -0.8 -0.9 0.0 0.2
Chest pain or discomfort 0.2 0.2 0.6 0.5 -0.8 0.0 0.2
Had major operations 0.4 0.5 1.8 -0.4 1.4 0.0 -0.2
Age at last live birth 0.8 1.2 4.4 -2.1 0.1 0.0 -0.5
Family relationship satisfaction 1.3 1.5 4.4 -2.1 -1.3 0.0 0.4
Leg pain on walking 0.9 1.2 2.4 -1.1 -1.6 0.0 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 3.8 1.9 -0.5 0.0 -0.7
Commuting to job workplace: Car/motor vehicle 2.3 2.6 4.4 1.9 1.5 0.0 -2.1
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 3.2 0.9 1.8 0.0 -0.9
Medication: Aspirin 0.1 0.1 0.4 -0.6 0.2 0.0 -0.2
Supplements: Vitamin C 0.5 0.5 1.6 -1.3 -0.3 0.0 0.7
Knee pain experienced in last month 1.4 2.2 7.8 -0.5 -2.8 0.0 -0.9
Hypertension (Self-reported) 0.4 1.2 2.5 -1.3 -1.6 0.0 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.6 1.3 -1.1 0.3 0.0 1.1
Illnesses of father: Heart disease 1.1 1.6 3.6 1.6 0.4 0.0 1.9
Illnesses of siblings: Diabetes 0.7 0.9 3.5 -0.4 0.2 0.0 -1.9
Smoking status: Previous 0.4 0.5 2.1 1.5 -0.1 0.0 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.8 -0.7 -1.4 0.0 -1.7
Whole body fat-free mass 0.2 0.9 2.7 -0.5 -0.8 0.0 -1.6
Leg fat-free mass (right) 0.3 1.5 4.0 -0.3 -1.3 0.0 -2.0
Arm fat percentage (left) 0.1 0.3 0.9 -0.4 -0.1 0.0 -1.0
Average weekly red wine intake 1.8 2.7 7.9 1.6 0.5 0.0 -2.8
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.0 -0.2 -1.4 0.0 -0.7
Mood swings 0.1 0.2 0.3 -0.6 -0.4 0.0 0.5
Loneliness, isolation 0.4 0.6 1.5 -0.8 -1.2 0.0 0.4
Long-standing illness, disability or infirmity 0.1 0.2 0.3 -0.5 -0.4 0.0 0.5
Ever had bowel cancer screening 0.8 0.9 1.8 1.4 1.2 0.0 0.6
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.8 0.3 0.0 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 2.5 -1.6 -0.4 0.0 -0.8
Friendships satisfaction 1.1 1.4 4.3 -1.0 -2.1 0.0 -0.4
Qualifications: nursing, teaching 0.6 0.9 1.6 0.9 -1.3 0.0 1.1
Commuting to job workplace: Walk 0.7 0.8 2.5 0.4 -1.6 0.0 0.7
Eye problems/disorders: Cataract 0.3 0.4 1.5 -0.1 -1.2 0.0 0.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.8 -0.8 -1.7 0.0 0.9
Medication for cholesterol 0.3 0.5 1.8 0.4 0.2 0.0 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 -0.4 0.5 0.0 0.1
Back pain experienced in last month 0.6 0.8 2.0 1.1 1.4 0.0 -0.3
Mineral and other dietary supplements 0.5 0.7 2.2 -0.8 -0.3 0.0 1.5
Breast cancer (self-reported) 0.1 0.2 0.5 -0.7 -0.3 0.0 0.2
Asthma (self-reported) 0.3 0.6 1.3 0.5 -0.9 0.0 -1.1
Osteoporosis (self-reported) 1.1 1.4 2.8 1.4 -1.0 0.0 1.7
Osteoarthritis (self-reported) 0.7 0.9 3.1 0.7 -0.3 0.0 -1.8
Medication: Aspirin 0.1 0.2 0.8 -0.9 -0.1 0.0 0.0
Medication: Gliclazide 0.1 0.1 0.3 -0.0 0.6 0.0 -0.1
Illnesses of father: None of the above (group 1) 0.7 0.9 3.2 -1.8 -0.2 0.0 -0.6
Smoking status: Current 0.4 0.6 1.2 -0.4 -1.0 0.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.9 -1.2 0.7 0.0 1.4
Whole body water mass 0.2 1.0 2.9 -0.5 -0.9 0.0 -1.7
Leg predicted mass (right) 0.3 1.4 4.0 -0.2 -1.3 0.0 -2.0
Arm fat mass (left) 0.1 0.4 1.6 -0.3 -0.2 0.0 -1.3
Number of self-reported non-cancer illnesses 0.4 0.7 2.8 -1.7 0.1 0.0 0.0
Average weekly champagne plus white wine intake 0.6 0.8 2.4 1.6 -0.9 0.0 0.3
Miserableness 0.2 0.4 1.5 0.2 -1.2 0.0 -0.1
Guilty feelings 0.6 0.9 2.2 -1.5 -1.1 0.0 0.6
Wears glasses or contact lenses 1.1 1.2 3.7 0.4 -1.0 0.0 1.9
Ever taken oral contraceptive pill 0.5 0.6 2.0 0.5 -1.4 0.0 0.1
Hearing aid user 1.2 1.4 2.8 1.7 1.7 0.0 -0.2
Mother’s age at death 0.8 0.9 2.2 1.5 -0.1 0.0 1.3
Financial situation satisfaction 0.0 0.1 0.2 -0.2 -0.1 0.0 -0.4
Tinnitus: Yes, now most or all of the time 2.1 2.4 5.4 -1.6 -1.3 0.0 2.3
Commuting to job workplace: Public transport 0.5 0.6 2.1 -1.5 -0.6 0.0 0.2
Eye problems/disorders: Glaucoma 1.1 1.3 3.1 0.0 1.4 0.0 -1.8
Medication: Blood pressure 1.0 1.8 3.6 -1.9 -1.9 0.0 0.5
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.7 -0.6 0.8 0.0 -0.8
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.2 0.5 0.3 0.0 -1.8
High cholesterol (Self-reported) 4.0 7.1 19.3 -1.1 2.8 0.0 4.4
Medication: Bendroflumethiazide 0.7 1.0 2.8 -1.1 -1.7 0.0 -0.3
Medication: Paracetamol 0.4 0.6 0.9 -0.7 -1.0 0.0 -1.0
Medication: Lisinopril 0.1 0.2 0.5 -0.7 0.4 0.0 0.2
Medication: Atorvastatin 0.8 1.0 2.6 0.2 1.6 0.0 1.1
Illnesses of father: High blood pressure 0.8 1.0 3.6 -0.4 -1.9 0.0 0.2
Alcohol drinker status: Never 0.8 0.9 2.4 -0.9 0.7 0.0 -1.6
Ever smoked 0.8 1.4 3.4 -0.7 -1.9 0.0 -1.2
Basal metabolic rate 0.2 0.9 3.3 -0.4 -0.5 0.0 -1.8
Leg fat percentage (left) 0.1 0.5 1.8 -0.3 1.3 0.0 0.2
Arm fat-free mass (left) 0.1 0.5 1.9 -0.4 -0.0 0.0 -1.4
Number of operations (self-reported) 0.4 0.5 1.2 0.9 -0.5 0.0 -1.1
Average weekly beer plus cider intake 1.0 1.4 5.4 -0.5 -2.3 0.0 -0.1
Irritability 0.6 1.1 2.4 -1.6 -0.9 0.0 1.0
Risk taking 0.2 0.2 0.8 -0.9 0.0 0.0 0.3
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.2 -1.5 -0.7 0.0 -1.0
Fractured/broken bones in last 5 years 0.6 0.7 1.9 -0.1 -1.4 0.0 -1.0
Age started oral contraceptive pill 0.6 0.8 1.7 -0.8 1.3 0.0 -0.8
Diastolic blood pressure, automated reading 0.9 2.7 6.1 -1.3 1.7 0.0 2.5
Ever depressed for a whole week 0.7 0.9 3.6 -0.1 -1.9 0.0 0.2
Unable to work because of sickness or disability 0.6 0.8 2.9 -0.4 -1.7 0.0 0.4
Commuting to job workplace: Cycle 0.5 0.7 1.5 -1.0 -1.2 0.0 0.4
Myopia 1.9 2.8 5.9 2.4 0.7 0.0 2.2
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.2 1.5 1.1 0.0 -0.7
Cholesterol lowering medication 0.9 1.4 2.8 -0.1 1.7 0.0 1.6
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.7 -1.1 0.7 0.0 -1.7
Pain experienced in last month 0.9 1.5 3.6 -1.2 1.9 0.0 -0.9
Supplements: Calcium 0.7 0.8 2.6 -0.8 -1.6 0.0 0.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 -0.0 -0.2 0.0 -0.5
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.9 0.9 1.7 0.0 1.7
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 3.8 -1.9 0.3 0.0 -1.3
Heart disease (siblings) 0.6 0.7 2.2 -1.5 -0.1 0.0 -0.7
Alcohol drinker status: Previous 1.6 1.9 3.4 -1.7 -1.2 0.0 1.8
Pack years of smoking 0.8 1.2 2.1 1.3 1.4 0.0 -1.0
Impedance of whole body 0.6 2.9 6.1 2.5 2.2 0.0 -0.9
Leg fat mass (left) 0.1 0.2 0.7 -0.0 0.5 0.0 -0.8
Arm predicted mass (left) 0.1 0.3 1.3 -0.2 -0.1 0.0 -1.1