Best TWAS P=1.55e-13 · Best GWAS P=2.83e-14 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POLR2J | 0.06 | 0.01 | blup | 245 | 0.03 | 4.0e-05 | -0.675 | 5.9 | 4.0e-09 | 0.26 | 0.14 | 0.18 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | POLR2J3 | 0.12 | 0.01 | enet | 34 | 0.06 | 1.0e-07 | 0.059 | -5.9 | 3.8e-09 | -0.06 | 0.12 | 0.06 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PRKRIP1 | 0.06 | 0.03 | enet | 9 | 0.04 | 1.4e-05 | 3.388 | -5.3 | 1.0e-07 | -0.15 | 0.46 | 0.03 | TRUE |
| 4 | GTEx | Artery Coronary | ARMC10 | 0.23 | 0.04 | lasso | 8 | 0.08 | 1.6e-03 | 6.974 | -6.5 | 6.7e-11 | -0.11 | 0.02 | 0.62 | TRUE |
| 5 | GTEx | Brain Cerebellar Hemisphere | LRWD1 | 0.26 | 0.07 | enet | 13 | 0.17 | 4.4e-05 | 4.607 | -5.2 | 2.6e-07 | -0.14 | 0.05 | 0.06 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | RASA4 | 0.11 | 0.06 | lasso | 2 | 0.05 | 8.9e-04 | 6.566 | -5.9 | 3.9e-09 | -0.06 | 0.04 | 0.83 | TRUE |
| 7 | GTEx | Breast Mammary Tissue | AC093668.2 | 0.31 | 0.18 | enet | 24 | 0.24 | 1.6e-12 | -3.847 | -5.2 | 2.4e-07 | -0.07 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | POLR2J | 0.28 | 0.01 | enet | 20 | 0.05 | 1.1e-02 | -3.984 | 5.5 | 4.0e-08 | 0.09 | 0.07 | 0.07 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | RASA4 | 0.06 | 0.00 | enet | 12 | 0.00 | 3.3e-01 | 6.566 | -6.0 | 1.8e-09 | 0.03 | 0.02 | 0.19 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | RP11-163E9.2 | 0.21 | 0.09 | lasso | 4 | 0.05 | 1.4e-02 | 6.972 | -6.8 | 8.2e-12 | -0.09 | 0.05 | 0.21 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | POLR2J3 | 0.32 | 0.08 | lasso | 7 | 0.11 | 8.6e-09 | -3.179 | -5.9 | 3.4e-09 | -0.09 | 0.42 | 0.57 | FALSE |
| 12 | GTEx | Esophagus Muscularis | POLR2J3 | 0.17 | 0.02 | lasso | 5 | 0.03 | 8.2e-03 | -3.126 | -6.7 | 1.9e-11 | -0.06 | 0.02 | 0.75 | FALSE |
| 13 | GTEx | Heart Left Ventricle | RASA4 | 0.09 | 0.03 | lasso | 7 | 0.03 | 9.4e-03 | 6.974 | -6.9 | 5.4e-12 | -0.07 | 0.02 | 0.91 | FALSE |
| 14 | GTEx | Heart Left Ventricle | POLR2J3 | 0.19 | 0.07 | enet | 13 | 0.10 | 3.5e-06 | 6.936 | -5.7 | 9.5e-09 | -0.08 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Heart Left Ventricle | RP11-514P8.8 | 0.21 | 0.02 | lasso | 5 | 0.14 | 1.2e-07 | 6.974 | -5.8 | 5.7e-09 | -0.09 | 0.13 | 0.78 | FALSE |
| 16 | GTEx | Lung | PRKRIP1 | 0.09 | 0.00 | enet | 20 | 0.01 | 6.1e-02 | 5.767 | -6.5 | 6.0e-11 | -0.28 | 0.06 | 0.20 | TRUE |
| 17 | GTEx | Lung | POLR2J3 | 0.31 | 0.01 | enet | 11 | 0.07 | 6.3e-06 | 6.936 | -7.4 | 1.5e-13 | -0.01 | 0.01 | 0.97 | TRUE |
| 18 | GTEx | Lung | RP11-514P8.8 | 0.15 | 0.00 | enet | 22 | 0.06 | 3.1e-05 | 6.655 | -5.3 | 1.0e-07 | 0.05 | 0.09 | 0.15 | TRUE |
| 19 | GTEx | Thyroid | NAPEPLD | 0.27 | 0.16 | enet | 19 | 0.20 | 5.7e-15 | -5.729 | -6.6 | 3.2e-11 | -0.15 | 0.95 | 0.05 | FALSE |
| 20 | GTEx | Whole Blood | POLR2J3 | 0.07 | 0.02 | enet | 20 | 0.03 | 1.5e-03 | 5.767 | -7.1 | 1.4e-12 | -0.01 | 0.03 | 0.92 | FALSE |
| 21 | NTR | Blood | NAPEPLD | 0.01 | 0.00 | blup | 282 | 0.00 | 4.5e-02 | 4.016 | -5.8 | 8.7e-09 | -0.08 | 0.08 | 0.28 | TRUE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | RP11-514P8.6 | 0.42 | 0.03 | enet | 49 | 0.11 | 1.6e-14 | -4.904 | 5.2 | 2.4e-07 | 0.03 | 0.98 | 0.00 | TRUE |
| 23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LRRC17 | 0.07 | 0.04 | lasso | 2 | 0.05 | 2.8e-11 | 4.577 | 6.2 | 5.0e-10 | 0.06 | 0.02 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | PMPCB | 0.04 | 0.01 | lasso | 4 | 0.02 | 3.5e-03 | -5.719 | -5.3 | 1.1e-07 | -0.14 | 0.00 | 0.66 | TRUE |
| 25 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LRWD1 | 0.02 | 0.01 | lasso | 3 | 0.02 | 9.8e-04 | -5.622 | -5.7 | 1.4e-08 | -0.09 | 0.00 | 0.88 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | NAPEPLD | 0.05 | 0.00 | blup | 20 | 0.03 | 3.4e-04 | -5.344 | -5.8 | 5.2e-09 | -0.11 | 0.00 | 0.26 | FALSE |
| 27 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC26A5 | 0.04 | 0.00 | blup | 56 | 0.02 | 6.5e-03 | 1.095 | -6.2 | 6.2e-10 | -0.05 | 0.02 | 0.70 | TRUE |