Hub : Genes

LRWD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1540 0.0500 1.6e-05 0.152 NA 0.132 NA 0.147 1.9e-12 NA 6.4e-11 NA 4.7e-12
2 GTEx Adipose Visceral Omentum 0.1110 0.0490 3.3e-03 0.048 NA 0.033 NA 0.031 1.6e-03 NA 7.7e-03 NA 9.2e-03
3 GTEx Artery Aorta 0.1740 0.0560 1.8e-05 0.121 NA 0.137 NA 0.109 3.6e-07 NA 5.8e-08 NA 1.4e-06
4 GTEx Artery Tibial 0.2277 0.0554 1.2e-09 0.166 NA 0.143 NA 0.157 5.3e-13 NA 2.8e-11 NA 2.5e-12
5 GTEx Brain Cerebellar Hemisphere 0.2650 0.1070 7.6e-03 0.072 NA 0.168 NA 0.063 6.7e-03 NA 4.4e-05 NA 1.0e-02
6 GTEx Brain Cerebellum 0.4720 0.0800 1.4e-07 0.239 NA 0.229 NA 0.286 1.1e-07 NA 2.2e-07 NA 4.1e-09
7 GTEx Esophagus Muscularis 0.1290 0.0480 3.8e-05 0.063 NA 0.043 NA 0.084 1.2e-04 NA 1.3e-03 NA 8.8e-06
8 GTEx Lung 0.1272 0.0414 3.7e-04 0.140 NA 0.103 NA 0.127 7.4e-11 NA 2.8e-08 NA 6.2e-10
9 GTEx Nerve Tibial 0.2370 0.0569 1.6e-08 0.229 NA 0.225 NA 0.220 3.1e-16 NA 6.8e-16 NA 1.4e-15
10 GTEx Ovary 0.3450 0.1040 3.0e-04 0.295 NA 0.224 NA 0.262 5.8e-08 NA 3.2e-06 NA 3.9e-07
11 GTEx Skin Not Sun Exposed Suprapubic 0.1580 0.0630 1.4e-03 0.113 NA 0.034 NA 0.095 9.0e-07 NA 5.7e-03 NA 6.6e-06
12 GTEx Skin Sun Exposed Lower leg 0.1310 0.0460 4.1e-04 0.073 NA 0.084 NA 0.079 1.2e-06 NA 2.0e-07 NA 4.2e-07
13 GTEx Testis 0.2900 0.0680 2.3e-10 0.339 NA 0.319 NA 0.335 9.9e-16 NA 9.9e-15 NA 1.5e-15
14 GTEx Thyroid 0.1750 0.0530 1.4e-06 0.111 NA 0.126 NA 0.126 8.0e-09 NA 7.8e-10 NA 7.0e-10
15 GTEx Uterus 0.4180 0.1140 9.6e-04 0.197 NA 0.094 NA 0.117 7.8e-05 NA 6.0e-03 NA 2.4e-03
16 GTEx Whole Blood 0.0980 0.0380 5.7e-04 0.060 NA 0.027 NA 0.062 3.1e-06 NA 1.5e-03 NA 2.2e-06
17 METSIM Adipose 0.1031 0.0277 2.4e-09 0.099 0.079 0.093 0.092 0.093 1.3e-14 6.3e-12 8.1e-14 1.3e-13 1.0e-13
18 NTR Blood 0.0386 0.0149 2.8e-04 0.006 0.011 0.002 0.010 0.006 3.4e-03 1.0e-04 4.9e-02 3.2e-04 3.2e-03
19 ROSMAP Brain Pre-frontal Cortex 0.2645 0.0466 0.0e+00 0.279 0.261 0.286 0.283 0.281 6.3e-36 2.2e-33 5.2e-37 1.5e-36 2.4e-36
20 YFS Blood 0.3617 0.0398 0.0e+00 0.288 0.438 0.444 0.439 0.438 2.5e-95 3.5e-160 6.4e-163 8.8e-161 2.4e-160
21 TCGA Breast Invasive Carcinoma 0.0163 0.0102 2.5e-03 0.010 0.006 0.001 NA 0.006 2.6e-03 1.7e-02 1.9e-01 NA 2.0e-02
22 TCGA Kidney Renal Clear Cell Carcinoma 0.0406 0.0217 1.2e-04 0.031 0.024 0.026 NA 0.024 2.0e-04 9.2e-04 6.0e-04 NA 8.8e-04
23 TCGA Kidney Renal Papillary Cell Carcinoma 0.0570 0.0360 7.8e-03 0.038 0.013 0.016 NA 0.018 3.0e-03 5.6e-02 4.0e-02 NA 3.0e-02
24 TCGA Lung Adenocarcinoma 0.0450 0.0293 7.6e-04 0.018 0.020 0.023 NA 0.019 3.1e-03 1.7e-03 8.3e-04 NA 2.2e-03
25 TCGA Lung Squamous Cell Carcinoma 0.0245 0.0176 6.8e-03 0.013 0.014 0.016 NA 0.023 1.1e-02 9.0e-03 5.6e-03 NA 9.8e-04
26 TCGA Ovarian Serous Cystadenocarcinoma 0.1030 0.0670 2.0e-03 0.000 0.033 0.064 NA 0.004 3.0e-01 2.7e-03 4.0e-05 NA 1.6e-01
27 TCGA Prostate Adenocarcinoma 0.0960 0.0482 7.5e-06 0.035 0.036 0.040 NA 0.024 1.2e-04 1.2e-04 4.2e-05 NA 1.4e-03
28 TCGA Skin Cutaneous Melanoma 0.1350 0.0760 4.9e-03 0.086 0.057 0.035 NA 0.047 2.7e-03 1.2e-02 4.1e-02 NA 2.1e-02
29 TCGA Thyroid Carcinoma 0.0460 0.0230 1.3e-05 0.053 0.031 0.036 NA 0.041 6.6e-06 4.7e-04 1.7e-04 NA 7.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Bipolar Disorder (2018) 0.2 0.3 2.7 0.2 0.3 1.2 0.4 -1.6 -0.5 0.5 0.4 0.5 0.7 0.3 0.7 -0.8 0.6 0.5 0.2 0.5 -0.7 0.1 0.3 -0.0 0.4 0.2 -0.1 0.1 0.5 -0.1 0.2 0.4
Bipolar Disorder or Schizophrenia 0.1 0.3 1.6 -0.3 0.2 0.3 -0.3 -0.8 -0.4 -0.0 -0.4 -0.3 0.5 -0.3 -0.2 -0.7 0.0 -0.1 -0.6 0.4 -0.7 0.0 0.5 0.1 -0.6 -1.1 -0.7 0.5 -1.3 -0.7 -0.2 0.7
Depressed Affect (Nagel 2018) 0.9 1.9 3.3 -1.6 -1.5 -0.7 -1.2 -1.7 -1.7 -1.7 -1.7 -1.5 -1.0 -1.6 -1.3 1.2 -1.4 -1.8 -1.0 -1.3 -1.2 -1.5 -1.2 -1.4 -1.8 -1.8 -1.3 -1.2 -0.2 -0.9 -1.6 -1.0
Depression (Nagel 2018) 0.1 0.2 1.0 0.1 0.1 0.5 0.3 -0.3 0.1 0.8 0.1 0.2 0.4 0.1 0.1 -0.4 0.4 0.3 0.4 0.4 -0.1 0.4 0.4 0.1 0.1 0.3 0.3 -0.8 1.0 0.6 -0.2 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.9 0.9 0.7 0.1 1.0 1.6 1.1 0.6 0.7 1.1 0.8 0.9 0.6 -0.7 0.5 0.7 0.2 0.9 0.3 0.9 0.7 0.9 0.5 0.3 1.5 1.2 1.1 1.7 0.8 1.1
Neuroticism (Nagel 2018) 0.8 1.9 4.4 -1.7 -1.4 -1.2 -1.3 -1.0 -1.5 -1.8 -1.9 -1.6 -0.9 -1.8 -1.2 1.2 -1.4 -1.8 -1.4 -1.2 -1.2 -1.2 -1.4 -1.4 -2.1 -1.9 -0.9 -0.9 -0.1 -0.7 -1.5 -0.7
Schizophrenia (2018) 0.3 0.5 4.0 -0.6 0.0 -0.6 -0.7 0.3 -0.1 -0.4 -0.8 -0.8 0.0 -0.6 -0.9 -0.2 -0.4 -0.5 -0.9 0.1 -0.4 -0.0 0.4 0.1 -1.1 -1.5 -0.7 0.6 -2.0 -0.7 -0.5 0.6
Schizophrenia vs Biploar Disorder 0.1 0.2 2.1 0.0 0.0 -0.2 0.5 1.4 0.0 0.7 0.0 0.0 0.0 0.6 0.3 -0.7 0.0 0.6 -0.3 0.7 -0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.3 0.6 1.9 -1.1 -0.7 -1.3 -0.9 -0.1 -0.5 -1.4 -1.2 -1.2 -0.2 -1.1 -0.5 0.4 -0.8 -0.9 -0.9 -0.6 -0.7 -0.3 -0.8 -0.6 -1.1 -0.8 0.5 -0.2 0.4 0.3 -0.6 -0.0
Alzheimer’s Disease (in mother) 0.7 0.8 4.6 -0.9 -1.1 -1.2 -1.4 0.6 -0.6 -0.4 -0.9 -0.5 -1.2 -1.0 -1.3 1.1 -1.1 -0.3 0.6 -0.4 0.5 -0.7 0.4 0.4 -0.7 -0.7 -1.2 0.9 -2.1 -1.0 -0.3 -0.1
Alzheimer’s Disease (in father) 0.1 0.2 0.5 0.0 -0.2 0.3 -0.2 -0.7 -0.1 0.4 0.0 -0.1 0.6 0.0 0.4 -0.7 0.2 0.1 -0.6 -0.0 -0.3 -0.0 -0.4 -0.3 -0.1 0.0 0.7 0.6 0.4 0.6 0.4 0.7
Alzheimer’s Disease (including proxy) 0.3 0.5 2.1 -0.8 -1.1 -0.7 -1.4 -0.9 -0.9 -0.3 -0.8 -0.6 -0.6 -0.9 -0.9 0.6 -0.8 -0.2 0.3 -0.3 -0.4 -0.6 0.4 0.0 -0.7 -0.8 -1.0 0.4 -1.1 -0.6 -0.4 -0.0
Crohns Disease (2017) 0.7 1.6 5.9 -1.2 -1.4 -1.0 -1.4 -1.7 -1.6 -0.8 -1.0 -0.8 -1.1 -1.1 -1.3 1.2 -1.0 -1.2 -0.4 -1.4 -1.0 -1.5 -1.3 -1.5 -0.7 -0.3 -0.9 -2.4 0.5 -0.9 -1.3 -2.0
Irritable Bowel Disease (IBD) 1.1 2.5 8.6 -1.5 -1.5 -0.9 -1.7 -2.9 -2.3 -1.2 -1.5 -1.3 -1.3 -1.4 -1.7 1.4 -1.4 -1.6 -0.7 -1.8 -0.7 -1.8 -1.6 -1.9 -1.3 -1.1 -0.6 -2.7 0.6 -0.5 -1.9 -2.1
Ulcerative Colitis (UC) 0.9 1.8 9.7 -1.3 -1.0 -0.3 -1.3 -3.1 -1.9 -1.1 -1.4 -1.2 -1.1 -1.2 -1.2 1.1 -1.4 -1.3 -0.6 -1.3 0.2 -1.3 -1.0 -1.4 -1.4 -1.4 -0.2 -2.0 0.5 0.1 -1.8 -1.5
Major Depression (MDD) 0.0 0.0 0.1 0.0 0.0 -0.3 -0.1 -0.0 0.0 -0.1 0.0 0.0 0.0 -0.1 -0.2 0.0 0.0 -0.2 0.2 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.6 3.0 10.3 1.5 1.8 1.2 2.0 3.2 2.3 1.7 1.4 1.3 2.2 1.5 1.8 -2.3 1.5 1.7 0.1 1.3 -0.2 1.8 0.5 0.7 1.3 1.3 2.5 1.4 1.8 2.2 1.6 2.0
Verbal and Numeric Reasoning (VNR) 1.7 4.2 8.3 2.1 2.2 1.6 2.4 2.3 2.3 2.0 2.0 2.3 2.0 2.1 2.0 -2.2 1.9 2.0 0.4 2.1 0.7 2.1 1.3 1.9 1.7 1.6 2.9 2.3 2.0 2.9 2.0 2.4
Breast Cancer 4.5 10.9 23.9 -3.0 -3.2 -4.5 -3.9 -2.7 -3.1 -4.3 -3.0 -3.0 -4.5 -3.1 -3.6 4.9 -3.9 -3.6 1.6 -2.9 -0.1 -3.3 -0.1 -1.1 -2.4 -1.7 -3.8 -3.0 -3.9 -3.6 -3.5 -4.1
Ovarian Cancer 0.2 0.3 1.7 -0.5 -0.6 0.1 0.1 0.5 -0.4 0.1 -0.4 -0.1 0.3 -0.5 0.7 -0.4 -0.3 -0.1 -1.1 -0.7 -0.1 -0.5 -0.9 -1.3 -0.2 0.2 1.0 -0.3 1.2 0.2 0.0 -0.0
Prostate Cancer 0.1 0.1 0.4 0.3 0.1 0.2 0.2 0.6 0.2 -0.1 0.3 0.2 0.4 0.3 0.3 -0.1 -0.0 0.1 -0.6 0.3 0.2 0.4 -0.1 -0.1 -0.0 -0.6 -0.1 0.5 -0.1 -0.3 0.2 0.5
Age at First Birth 0.5 0.7 6.2 0.5 0.9 0.3 0.6 2.5 1.4 0.3 0.5 0.7 -0.3 0.6 0.6 0.0 0.4 0.5 0.7 0.3 1.6 0.5 0.5 0.9 0.7 1.0 1.0 1.0 -0.1 0.9 0.7 0.3
Bipolar Disorder (2011) 0.1 0.1 0.8 0.0 0.0 0.2 0.0 -0.9 0.0 0.3 0.0 0.0 0.0 -0.4 0.0 0.0 0.0 -0.3 -0.3 0.0 -0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.7 -0.5 -0.7 -0.6 -0.7 -0.4 -0.5 -1.0 -0.5 -0.1 -1.4 -0.4 -0.7 1.5 -0.5 -0.5 1.1 -0.6 0.9 -0.7 -0.1 0.1 -0.1 0.3 -0.3 -1.6 0.4 0.3 -0.9 -1.6
Coronary Artery Disease (CAD) 0.9 1.1 8.5 0.0 0.0 -1.5 -1.9 -2.9 0.0 -1.1 0.0 -1.7 0.0 -1.5 -1.6 1.6 0.0 -1.5 0.3 -1.1 -0.9 -1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.6 4.5 -0.4 -0.9 -0.1 -0.9 -2.1 -1.1 0.1 -0.2 -0.1 -0.6 -0.3 -0.6 0.7 -0.3 -0.4 0.3 -0.5 -0.0 -0.8 -0.3 -0.6 -0.0 0.1 -0.7 -1.7 1.0 -0.5 -0.8 -1.3
Mean Putamen Volume 0.4 0.4 4.5 0.4 -0.1 0.1 -0.1 -2.1 -0.5 0.2 0.5 0.1 0.5 0.4 0.6 -0.2 0.4 0.2 -0.3 0.5 -1.4 -0.0 0.1 -0.5 0.4 -0.1 -0.9 -0.7 0.4 -1.1 -0.0 -0.2
Fasting Glucose 0.8 1.0 2.3 0.1 1.1 0.2 0.6 1.5 1.1 -0.1 0.2 1.1 1.0 0.1 0.9 -0.8 0.7 0.9 1.3 0.9 1.0 1.2 1.4 1.3 0.6 0.7 1.4 1.5 0.2 1.5 1.0 1.4
HbA1C 0.5 0.5 4.9 -0.3 0.7 -0.4 -0.3 2.2 0.3 0.5 -0.0 -0.1 -0.1 -0.4 -0.3 -0.1 0.4 0.6 1.3 0.2 1.8 0.9 0.8 0.8 0.4 0.5 0.0 0.6 -0.9 0.1 0.6 0.2
HDL Cholesterol 0.3 0.5 2.5 0.5 0.2 0.0 0.6 0.5 0.6 0.0 0.5 0.5 0.6 0.5 0.8 -0.6 0.4 0.1 -0.6 0.3 -0.9 0.3 -0.4 0.2 0.6 0.8 1.4 0.3 1.6 1.4 0.6 0.5
LDL Cholesterol 0.6 1.0 3.3 -0.9 -1.3 -0.7 -1.5 -1.8 -1.6 -0.3 -0.6 -0.9 -1.4 -0.9 -0.9 1.3 -0.9 -0.6 -0.1 -1.2 0.6 -1.0 -0.8 -0.8 -0.3 -0.2 -1.2 -0.7 -0.9 -1.0 -0.7 -1.3
Lupus 0.4 0.6 4.0 0.7 0.1 0.3 0.0 -0.5 0.2 0.5 0.7 0.3 -0.2 0.7 0.6 -0.1 0.4 0.6 1.2 0.2 0.1 0.5 0.4 0.9 0.9 1.2 1.5 -0.0 1.5 2.0 0.5 -0.2
Neuroticism (2016) 2.9 4.2 8.2 -2.7 -1.7 -2.6 -2.4 -1.4 -2.1 -2.4 -2.9 -2.8 -1.6 -2.8 -2.3 1.9 -2.1 -2.6 -1.3 -2.1 -1.2 -1.7 -1.8 -1.7 -2.7 -2.2 -1.1 -1.7 -0.9 -0.9 -2.3 -1.4
Primary Biliary Cirrhosis 4.4 6.2 13.6 -2.5 -2.5 -2.3 -3.2 -2.7 -3.1 -1.9 -2.4 -2.3 -3.3 -2.5 -2.9 3.2 -2.5 -2.3 0.6 -2.8 0.9 -2.7 -1.2 -1.9 -1.9 -1.6 -2.7 -3.5 -1.3 -2.1 -2.7 -3.7
Rheumatoid Arthritis 0.7 0.9 2.5 1.0 1.1 0.8 1.0 0.4 1.1 1.6 1.1 1.1 0.9 1.0 1.2 -1.0 1.1 1.3 0.4 0.7 -0.3 0.9 0.5 0.6 1.1 1.0 1.0 1.0 0.9 0.9 1.2 0.9
Schizophrenia (2014) 0.2 0.4 1.8 -0.2 0.5 -0.1 -0.2 -0.1 -0.0 0.4 -0.3 -0.6 0.8 -0.2 0.3 -1.2 0.0 -0.1 -1.1 0.2 -0.8 0.3 0.3 0.0 -0.6 -0.8 0.5 1.3 -1.3 0.0 0.2 1.3
Triglycerides 0.1 0.2 3.1 -0.1 0.3 0.1 -0.4 -0.1 -0.2 0.0 -0.0 -0.1 -0.3 -0.1 -0.3 0.3 0.1 0.2 0.5 -0.1 1.8 0.1 0.3 0.0 -0.0 -0.0 -0.5 0.0 -0.7 -0.4 -0.0 -0.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 -1.0 -0.8 -1.2 -0.9 1.2 -0.5 -1.2 -1.1 -1.0 -1.1 -1.0 -1.1 1.1 -1.0 -1.0 -0.3 -0.9 -0.2 -0.7 -0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.7 2.4 10.4 -2.1 0.0 -1.7 -2.0 -3.2 -2.5 -2.1 -2.0 -2.2 -1.7 -2.0 -1.9 1.8 0.0 -2.3 -1.0 0.0 -0.2 -2.2 -2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Blood Eosinophil Count 0.3 2.2 22.0 0.3 1.2 1.6 1.9 4.7 1.6 0.5 0.3 0.5 2.3 0.3 1.3 -2.1 0.8 0.3 -1.6 0.5 0.4 0.7 -1.2 -0.7 0.1 0.0 1.9 1.2 0.4 1.2 1.0 2.0
Blood Platelet Count 0.3 3.8 7.5 -2.2 -2.6 -2.1 -1.4 1.3 -1.5 -2.5 -2.4 -2.0 -2.1 -2.1 -2.0 2.0 -2.7 -2.6 -0.9 -2.0 0.7 -2.0 -1.5 -1.7 -2.3 -1.7 -0.6 -2.4 -1.6 -0.4 -2.5 -2.1
Blood Red Count 0.2 1.6 4.8 1.3 1.4 0.8 0.9 2.2 0.9 1.6 1.7 1.1 0.5 1.3 1.0 -0.5 1.7 1.4 1.5 0.8 0.8 1.3 0.5 1.0 2.1 1.9 0.0 1.2 0.6 -0.1 1.8 0.5
Blood White Count 0.0 0.3 2.5 -0.1 -1.3 0.2 0.1 1.5 -0.0 -0.2 0.2 -0.2 -0.2 -0.1 0.0 0.2 -0.2 -0.1 0.6 -0.6 0.1 -0.3 -0.7 -0.2 0.7 1.6 0.6 -0.1 0.6 0.4 0.5 -0.4
Heel T-Score 1.4 11.3 16.7 -3.4 -3.5 -3.8 -3.5 -1.8 -3.4 -3.5 -3.5 -4.0 -3.2 -3.4 -4.1 3.5 -3.7 -3.6 -2.2 -3.1 -2.9 -3.4 -3.0 -2.8 -3.6 -3.7 -3.8 -2.7 -3.5 -3.6 -3.6 -2.9
BMI 0.1 0.6 3.6 0.1 -0.4 0.8 -0.1 -1.9 -1.1 -0.3 -0.1 0.4 -0.5 0.1 -0.7 0.5 -0.0 -0.0 1.4 0.8 -1.1 0.0 1.5 1.1 -0.2 -0.6 -1.5 -0.5 -0.8 -0.5 -0.7 -0.4
Height 0.2 3.1 18.4 -0.4 1.7 -0.9 0.4 2.4 0.6 -0.7 -0.8 -0.3 2.9 -0.5 0.6 -1.9 0.5 -0.1 -4.3 0.7 -4.2 0.5 -2.1 -1.0 -1.9 -2.8 1.2 1.3 -0.3 0.6 -0.1 2.9
Waist Hip Ratio (WHR) 0.7 3.0 6.1 1.6 1.6 2.2 2.2 1.9 1.8 1.4 1.6 1.8 0.8 1.6 2.5 -1.1 1.4 1.1 2.3 1.7 1.2 1.4 2.3 1.9 2.0 2.4 2.0 1.1 1.4 1.8 1.6 0.9
Systolic Blood Pressure 0.2 0.8 6.1 0.4 0.4 -0.1 0.9 0.6 0.2 -0.2 0.6 0.4 1.5 0.4 1.0 -1.3 0.8 -0.1 -1.8 0.3 -2.5 0.4 -1.1 -0.9 0.5 0.5 0.6 0.7 1.0 -0.5 0.9 1.0
Smoking Status 0.1 0.3 1.5 0.1 -0.7 0.7 0.3 -0.1 0.2 -0.3 0.3 0.3 -0.1 0.1 0.4 -0.2 0.0 0.4 1.2 -0.3 1.2 -0.1 0.8 0.0 0.7 1.1 0.3 0.4 0.1 0.1 0.6 -0.0
Allergy or Eczema 1.1 2.8 13.0 1.3 1.5 0.6 1.6 3.6 1.8 0.8 1.5 1.4 1.7 1.2 2.0 -1.5 1.5 1.3 1.1 0.9 2.0 1.3 0.8 1.1 1.8 2.0 1.7 2.5 -0.5 1.2 2.3 2.1
Cardiovascular Disease 0.2 0.8 1.8 1.0 1.4 0.7 1.1 0.9 0.7 0.7 1.2 0.8 1.3 1.0 0.9 -1.1 1.2 0.7 0.8 1.3 -0.0 1.2 1.0 0.6 1.1 0.6 -0.4 0.1 -0.1 -0.8 0.8 0.6
Hypothyroidism (self reported) 0.5 1.2 5.3 0.1 0.3 -0.5 0.5 2.3 1.3 0.1 0.0 -0.5 1.4 0.0 0.3 -1.5 0.3 -0.2 -2.0 0.2 -1.7 0.4 -0.9 -0.3 -0.2 -0.0 1.5 2.2 -0.4 0.7 1.1 2.1
Respiratory disease 0.2 0.4 1.8 0.4 0.9 0.3 1.0 0.9 0.9 0.7 0.4 0.4 0.2 0.4 0.2 -0.7 0.3 0.7 0.3 0.9 0.2 0.5 1.3 0.8 0.3 0.3 0.2 1.0 -0.8 -0.1 0.4 0.7
Type 2 Diabetes (T2D) (2018) 4.0 7.5 20.6 3.0 2.5 2.6 2.7 2.4 2.5 2.8 2.9 3.1 1.7 2.8 1.6 -1.7 2.7 2.8 4.5 3.0 2.8 2.7 3.9 4.0 3.1 2.9 1.4 2.5 -0.0 2.6 2.6 2.1
Lung FEV1/FVC ratio 0.3 1.6 5.4 -0.9 -0.9 0.2 -1.0 -0.5 -0.7 -0.9 -0.8 -0.7 -2.2 -0.9 -1.8 2.0 -1.0 -0.7 2.0 -0.7 2.3 -0.9 0.9 0.2 -0.4 -0.1 -1.5 -1.7 -0.9 -0.9 -1.3 -2.2
Lung FVC 0.1 0.7 2.5 0.5 0.6 -0.3 0.2 0.1 0.5 -0.1 0.4 0.9 1.6 0.4 0.8 -1.0 0.9 0.5 -0.9 0.7 -0.5 1.0 -0.2 0.4 0.1 -0.3 1.2 0.9 1.5 1.5 0.9 1.5
Neuroticism 0.3 0.7 1.8 -1.1 -0.9 -0.6 -0.7 -0.2 -0.9 -1.4 -1.2 -1.0 0.0 -1.2 -0.6 0.3 -0.8 -1.2 -0.9 -0.9 -0.8 -0.5 -1.2 -1.0 -1.2 -1.0 0.3 -0.5 0.2 0.4 -0.8 -0.0
Chronotype (morning person) 6.2 14.4 32.3 -4.0 -2.3 -3.5 -4.5 -5.2 -4.0 -2.9 -3.8 -4.4 -3.4 -3.9 -2.9 2.7 -3.8 -3.8 -2.2 -3.8 -2.0 -3.7 -1.7 -4.6 -3.6 -3.2 -3.8 -5.7 -3.1 -5.1 -4.5 -4.8
Hair Pigment 0.0 0.9 3.3 -0.7 -1.3 -1.8 -1.1 -1.8 -1.1 -1.1 -0.7 -0.8 0.4 -0.7 -0.6 0.4 -0.5 -0.7 -0.7 -0.9 -1.3 -0.8 -0.6 -0.7 -0.8 -0.8 -1.2 -0.3 -1.4 -1.3 -0.4 0.2
Tanning 0.1 1.3 3.3 1.2 0.7 1.3 1.1 0.6 1.3 0.9 1.3 1.1 0.6 1.3 1.3 -1.1 1.0 1.1 1.2 1.0 1.1 1.1 1.3 1.3 1.5 1.8 1.3 0.9 0.7 1.2 1.3 0.6
Hand grip strength (left) 1.7 4.5 11.2 -1.8 -2.5 -2.8 -2.5 -3.3 -2.4 -2.8 -1.9 -2.1 -1.5 -1.8 -1.9 2.3 -2.3 -2.0 -1.1 -1.6 -2.3 -2.0 -1.4 -1.6 -2.1 -2.2 -2.2 -1.8 -1.5 -2.1 -2.3 -1.6
Number of treatments/medications taken 0.3 0.6 2.8 -0.7 -1.0 -0.5 -0.4 -0.4 -1.1 -0.4 -0.7 -0.8 0.1 -0.8 -0.7 -0.2 -0.6 -0.8 -0.3 -0.1 -0.8 -0.5 0.1 -0.6 -0.8 -1.0 -1.2 -0.6 -1.7 -1.3 -0.6 -0.2
Average weekly spirits intake 0.3 0.4 6.0 0.2 0.1 0.8 -0.1 -2.5 -0.6 -0.1 0.1 0.4 -0.1 0.2 0.1 0.2 0.2 0.1 1.2 0.6 -0.2 -0.1 1.1 0.5 0.1 0.0 -0.7 -0.8 0.3 -0.1 -0.5 -0.4
Sensitivity / hurt feelings 0.7 1.2 2.6 -1.3 -1.3 -0.7 -1.4 -0.9 -1.1 -0.9 -1.3 -1.5 -1.1 -1.4 -1.4 1.1 -1.2 -1.3 -0.4 -1.6 -0.8 -1.3 -1.3 -1.1 -1.1 -0.6 -0.5 -1.1 -0.2 -0.3 -1.1 -1.1
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.6 -0.1 -0.0 0.3 -0.1 -0.5 -0.1 0.2 -0.1 -0.2 0.7 -0.1 0.1 -0.7 0.2 0.1 -0.1 0.0 -0.8 0.3 0.0 -0.5 -0.1 -0.1 0.4 -0.2 0.2 0.3 0.1 0.3
Hearing difficulty/problems: Yes 1.4 2.1 5.3 1.4 1.4 2.2 1.5 0.0 0.9 2.3 1.5 1.6 1.4 1.4 1.6 -1.9 1.5 2.0 0.2 1.2 0.1 1.2 0.7 0.7 1.6 1.7 1.6 1.1 2.0 1.1 1.5 1.2
Relative age of first facial hair 1.6 3.2 6.6 2.0 2.6 1.9 1.8 1.1 1.8 2.0 1.8 2.0 2.0 2.0 1.8 -2.1 2.1 2.2 -0.0 2.2 0.4 2.1 1.2 1.7 1.4 0.9 1.6 1.9 1.5 1.5 1.6 2.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 5.6 0.0 -0.1 -0.4 -0.2 1.3 0.3 0.8 -0.0 -0.9 -0.5 -0.0 -0.7 -0.1 -0.3 -0.2 0.4 -0.2 0.8 -0.1 0.4 0.4 -0.1 0.1 -0.7 0.8 -2.4 -0.6 0.1 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.7 0.4 -0.2 0.6 0.8 1.0 0.5 0.6 0.6 0.3 1.1 0.3 0.6 -1.2 0.5 0.3 -0.4 -0.1 -0.9 0.3 -0.8 -0.2 0.9 1.3 1.2 1.2 0.2 0.6 1.3 1.1
Ever had hysterectomy (womb removed) 1.3 1.5 3.1 1.1 0.4 1.2 1.2 1.7 1.2 1.1 1.2 1.1 1.2 1.1 1.6 -1.4 1.1 1.3 0.6 1.0 0.6 1.1 0.5 1.0 1.4 1.7 1.4 1.7 0.8 1.1 1.7 1.4
Systolic blood pressure, automated reading 0.1 0.2 1.5 0.0 -0.5 -0.2 0.3 -0.1 -0.6 -0.5 0.3 0.3 0.0 0.1 0.1 0.3 0.0 -0.3 -0.5 -0.3 -1.2 -0.2 -0.8 -0.6 0.5 0.3 -0.3 0.1 0.4 -0.7 0.3 -0.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 3.7 0.0 0.1 -0.1 0.3 0.5 0.5 -0.5 -0.0 0.1 -0.9 -0.0 -0.4 0.4 -0.3 -0.0 1.9 0.1 1.6 -0.4 1.2 0.9 0.5 1.3 0.4 -0.6 -0.2 0.5 -0.3 -0.9
Angina 0.9 1.2 7.1 -0.7 -1.2 -0.4 -1.0 -2.7 -1.4 -1.2 -0.9 -0.9 -1.3 -0.7 -1.1 1.2 -1.3 -1.1 0.6 -0.6 0.2 -1.0 0.1 -0.3 -1.0 -0.9 -0.5 -2.0 -0.0 0.1 -1.6 -1.6
Medication for hormone replacement therapy 0.4 0.4 1.3 -0.6 -1.0 -0.1 -0.9 -0.8 -0.9 -0.3 -0.5 -0.7 -0.6 -0.6 -0.8 0.4 -0.4 -0.7 0.6 -0.8 -0.3 -0.5 -0.2 -0.4 -0.1 0.1 -0.9 -0.7 -1.2 -0.7 -0.3 -0.8
Vitamin and mineral supplements 0.8 1.1 2.8 -0.8 -1.1 -1.2 -1.0 -1.7 -1.6 -1.3 -0.9 -0.9 -0.7 -0.8 -0.9 1.0 -1.1 -1.3 -1.2 -1.1 -1.3 -1.1 -1.5 -1.0 -0.9 -0.8 -0.6 -0.6 -0.5 -0.8 -1.0 -0.6
Supplements: Zinc 1.1 1.2 3.0 1.0 1.1 1.0 1.0 1.7 0.9 1.6 1.0 1.0 0.9 0.9 1.5 -1.2 1.3 1.5 0.1 1.2 1.0 1.3 0.6 0.9 0.8 0.6 0.7 1.3 0.6 0.7 1.2 1.2
Medication: Co-codamol 0.2 0.2 0.9 -0.5 -0.7 -0.0 -0.1 0.6 -0.5 -0.8 -0.5 -0.3 -0.4 -0.5 -0.4 0.3 -0.6 -0.3 0.2 -0.2 1.0 -0.2 0.3 0.1 -0.4 -0.3 0.0 0.2 0.0 0.2 -0.3 -0.1
Medication: Metformin 1.7 2.4 5.7 1.7 0.8 1.8 1.4 0.9 0.9 1.9 1.6 1.8 1.0 1.6 0.8 -1.3 1.6 2.0 2.2 1.8 1.8 1.6 2.0 2.4 1.6 1.5 0.1 1.8 -0.3 0.9 1.5 1.4
Diabetes (father) 3.4 4.2 8.2 2.3 2.7 2.0 2.1 1.2 2.2 1.9 2.1 2.2 1.5 2.2 1.4 -1.2 2.4 2.1 2.4 2.5 2.5 2.4 2.5 2.9 1.9 1.3 1.5 1.5 1.3 2.5 1.8 1.6
Diabetes (mother) 0.2 0.3 1.0 0.1 0.4 0.5 0.4 0.6 0.2 0.0 0.0 0.7 0.6 0.0 0.0 -0.3 0.6 0.5 0.4 0.8 1.0 0.4 0.6 0.9 -0.1 -0.3 0.3 1.0 0.3 0.9 0.5 1.0
Severe depression (siblings) 1.8 2.0 5.3 1.2 1.2 1.4 1.4 1.9 1.7 1.4 1.1 1.4 0.7 1.2 1.2 -1.2 1.1 1.5 1.5 1.3 2.3 1.3 1.6 1.8 1.1 1.3 1.7 1.6 -0.2 2.0 1.4 1.2
Pack years adult smoking proportion 0.5 0.8 4.8 -0.8 -0.9 -0.7 -1.3 -2.2 -1.1 -0.9 -0.9 -1.2 -0.9 -0.8 -1.1 0.7 -1.0 -0.8 0.7 -0.6 0.1 -0.7 0.4 -0.3 -0.7 -0.4 -0.7 -0.6 -0.7 -0.4 -0.9 -0.7
Impedance of leg (right) 3.5 17.0 27.6 3.9 4.4 4.4 3.9 4.6 4.8 4.5 4.1 4.1 4.2 3.9 4.3 -4.5 4.8 4.6 0.8 3.4 2.4 4.4 1.9 2.9 4.2 4.1 4.7 5.2 3.2 4.0 5.3 4.7
Leg fat-free mass (left) 0.4 2.0 6.8 -1.1 -0.8 -1.1 -1.0 -2.0 -1.7 -1.3 -1.4 -0.9 -0.8 -1.1 -1.3 1.0 -1.3 -1.2 -0.7 0.0 -2.4 -1.0 -0.0 -0.1 -2.0 -2.6 -2.1 -1.6 -1.6 -1.4 -2.3 -0.8
Trunk fat percentage 0.2 1.0 4.1 0.6 1.2 2.0 0.7 -0.3 -0.2 1.6 0.3 1.1 0.8 0.6 0.3 -1.1 1.3 1.2 0.6 1.6 -0.0 1.1 1.4 1.5 -0.0 -0.6 0.2 0.4 0.7 1.4 0.1 0.9
Hand grip strength (right) 2.9 7.8 22.3 -2.7 -3.0 -3.2 -3.3 -4.7 -3.3 -3.5 -2.7 -2.8 -2.2 -2.7 -2.6 2.8 -2.9 -2.9 -1.6 -2.4 -2.8 -2.8 -1.9 -2.5 -2.7 -2.6 -2.6 -2.7 -1.4 -2.7 -3.0 -2.4
Townsend deprivation index at recruitment 4.9 6.9 15.0 -2.6 -3.2 -2.1 -3.2 -3.5 -3.2 -1.8 -2.8 -2.6 -3.9 -2.7 -3.2 3.0 -3.2 -2.6 0.5 -2.3 0.4 -2.6 -0.5 -0.9 -2.5 -1.9 -3.1 -2.5 -2.5 -2.3 -3.1 -3.3
Current tobacco smoking 0.9 1.5 3.2 -1.2 -1.8 -1.4 -1.2 -1.6 -1.3 -1.8 -1.2 -1.1 -1.3 -1.2 -1.1 1.5 -1.7 -1.1 0.1 -1.4 -0.1 -1.6 -0.4 -1.1 -0.9 -0.6 -0.7 -1.3 -0.4 -0.7 -1.3 -1.4
Average weekly fortified wine intake 0.7 0.8 3.3 0.5 0.8 0.2 0.5 1.1 0.4 0.9 0.3 0.9 1.1 0.5 1.0 -1.0 1.0 0.7 -0.5 0.9 0.7 0.9 0.2 0.9 0.1 -0.1 1.4 1.5 0.8 1.8 0.8 1.6
Maternal smoking around birth 0.3 0.4 1.8 0.2 0.2 0.4 0.4 -0.2 0.1 0.3 0.3 0.2 0.9 0.3 0.8 -1.0 0.6 -0.0 -0.9 0.1 -1.3 0.0 -0.8 -0.3 0.3 0.6 0.9 0.8 1.2 0.6 0.6 1.0
Fed-up feelings 0.1 0.1 0.8 -0.2 -0.5 0.6 -0.2 -0.9 -0.3 -0.3 -0.1 0.0 0.4 -0.2 0.2 -0.1 0.0 0.1 0.0 -0.1 -0.6 -0.0 -0.3 -0.3 0.0 0.2 0.1 0.1 0.8 0.1 0.3 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 1.0 0.4 0.4 0.4 0.4 0.0 0.3 0.3 0.5 0.3 1.0 0.4 0.6 -0.8 0.6 0.5 0.5 0.5 -0.0 0.5 0.3 0.2 0.4 0.3 0.2 0.6 -0.0 0.3 0.6 0.8
Relative age voice broke 0.5 0.7 3.2 0.7 1.1 0.4 0.6 1.8 0.6 0.7 0.5 0.7 1.0 0.7 0.4 -0.9 0.9 0.9 -0.7 1.1 -0.1 1.3 -0.1 0.7 0.1 -0.2 0.7 0.8 1.4 0.8 0.4 1.2
Taking other prescription medications 0.6 0.9 3.0 0.7 0.3 0.9 1.0 1.5 0.7 1.4 0.6 0.4 1.5 0.6 0.8 -1.7 0.8 0.6 -0.3 1.0 -0.1 1.1 0.5 0.6 0.4 0.2 0.9 1.3 -0.4 0.9 1.1 1.6
Age when periods started (menarche) 0.3 0.7 2.1 -0.6 0.3 -1.1 -0.9 -0.6 -0.1 -0.9 -0.7 -0.2 -1.1 -0.6 -1.1 1.1 -0.5 -0.6 1.4 -0.0 1.1 0.1 1.4 0.8 -0.6 -0.6 -0.9 -1.1 -0.8 -0.1 -0.9 -1.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 4.2 -0.0 0.1 0.2 0.5 0.3 0.1 -0.0 0.1 -0.2 1.2 0.0 0.7 -1.0 0.2 -0.2 -1.6 -0.1 -2.1 0.0 -1.4 -1.0 -0.1 -0.1 0.5 0.6 0.3 -0.1 0.4 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 7.2 -1.6 -2.0 -1.5 -1.9 -0.7 -1.8 -1.4 -1.7 -2.0 -1.9 -1.7 -1.8 1.6 -1.9 -1.6 -1.0 -1.6 -1.6 -1.7 -1.4 -1.2 -1.9 -1.9 -2.0 -0.3 -2.7 -1.8 -1.4 -1.1
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 6.8 -1.5 -1.7 -1.2 -1.6 -2.6 -1.6 -1.7 -1.4 -2.0 -0.9 -1.4 -1.8 1.1 -1.4 -1.4 -1.1 -1.7 -0.7 -1.8 -1.4 -1.8 -1.3 -1.3 -1.7 -0.8 -1.3 -2.0 -1.2 -0.9
Qualifications: CSEs or equivalent 1.4 1.9 5.4 1.3 1.4 1.5 1.9 0.2 1.0 1.6 1.3 1.3 1.6 1.4 1.6 -2.0 1.3 1.8 0.1 1.3 0.4 1.5 0.7 0.7 1.2 1.3 1.9 0.0 2.3 1.9 0.8 0.9
Serious illness, injury or assault to yourself 1.1 1.3 2.2 1.4 0.8 0.8 1.0 0.9 1.2 1.5 1.4 1.2 1.1 1.4 1.1 -1.0 1.2 1.4 0.7 1.5 0.6 1.3 1.2 1.3 1.2 0.9 0.9 1.3 0.7 1.1 1.3 1.3
High blood pressure 0.4 1.1 2.7 1.3 1.6 0.9 1.2 0.4 0.6 0.6 1.4 1.2 1.6 1.3 1.3 -1.1 1.6 0.8 0.7 1.5 -0.4 1.3 1.0 0.8 1.3 0.8 -0.0 0.6 -0.1 -0.1 1.1 1.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 5.6 0.6 1.0 0.1 0.6 2.1 0.8 0.3 0.7 0.6 0.5 0.5 0.9 -0.2 0.7 0.5 1.5 0.4 2.4 0.6 0.9 0.9 1.1 1.1 0.4 0.9 -1.1 0.3 1.1 0.6
Multivitamins +/- minerals 0.9 1.2 3.5 0.9 0.8 1.2 1.4 1.9 1.6 1.1 1.0 0.9 0.3 0.9 0.9 -0.8 0.8 1.0 1.6 1.1 1.3 0.8 1.6 1.3 1.1 1.3 0.6 1.0 -0.1 0.6 1.1 0.6
Stomach or abdominal pain in last month 0.8 1.0 3.9 0.9 0.9 0.3 0.8 1.2 1.1 1.4 0.8 0.3 0.7 0.9 0.6 -1.1 0.7 0.9 1.7 1.0 1.6 0.9 2.0 1.2 0.8 0.8 0.3 0.5 -1.2 0.4 0.5 0.7
Supplements: Glucosamine 2.7 3.5 6.6 1.9 1.3 2.3 2.2 2.4 1.8 1.9 2.0 2.4 2.2 1.9 2.2 -2.0 2.1 2.1 -0.1 1.7 -0.0 2.1 0.2 1.0 1.9 1.4 2.3 1.1 2.6 2.2 2.1 1.7
Diverticular disease/diverticulitis (self-reported) 3.4 4.0 9.4 2.1 1.9 2.2 2.4 2.0 2.1 2.7 2.2 1.7 2.6 2.1 2.4 -3.1 2.4 2.3 -0.0 1.7 0.1 2.3 0.8 0.8 2.0 1.9 1.8 1.6 1.7 1.4 2.2 2.1
Medication: Atenolol 0.5 0.6 1.3 1.0 1.1 0.6 0.8 -0.2 0.7 0.1 1.0 0.6 0.7 1.1 0.8 -0.9 0.9 0.6 0.1 1.1 -0.2 0.8 0.7 0.8 0.9 0.9 1.1 0.2 0.9 0.9 0.7 0.5
Medication: Levothyroxine sodium 0.5 0.9 5.1 -0.2 0.1 -0.5 0.4 2.3 0.8 -0.2 -0.3 -0.8 0.9 -0.3 -0.1 -1.0 0.1 -0.5 -2.2 -0.1 -1.5 0.0 -1.5 -0.5 -0.7 -0.6 0.9 1.7 -0.3 0.5 0.5 1.6
Sitting height 0.1 0.5 2.7 -0.4 0.8 -0.1 0.6 1.1 0.7 -1.6 -0.7 -0.1 0.5 -0.4 0.4 -0.2 -0.3 -0.7 -1.0 0.7 -1.0 -0.3 0.1 0.3 -1.2 -1.4 0.8 0.2 -0.5 0.6 -0.6 0.9
Chronic bronchitis/emphysema (father) 1.0 1.2 4.8 -1.2 -0.6 -0.8 -0.7 -0.3 -0.9 -0.9 -1.2 -1.2 -0.2 -1.2 -0.6 0.0 -0.8 -1.2 -2.1 -1.5 -2.0 -1.2 -2.2 -1.8 -1.2 -0.9 0.2 -0.0 -0.1 -0.3 -0.5 -0.0
High blood pressure (mother) 0.2 0.3 1.3 -0.3 0.5 0.0 0.1 1.1 0.4 -0.4 -0.3 -0.8 -0.7 -0.3 -0.9 0.7 -0.5 -0.5 0.3 -0.6 1.1 -0.2 -0.3 -0.4 -0.3 -0.1 -0.0 -0.5 -0.4 -0.1 -0.5 -0.7
Body mass index (BMI) 0.3 1.3 4.5 -0.6 -1.0 0.2 -0.8 -2.1 -1.8 -0.5 -0.8 -0.4 -1.5 -0.6 -1.4 1.4 -0.8 -0.5 1.3 0.1 -0.3 -0.7 1.1 0.8 -0.9 -1.1 -2.1 -1.5 -1.1 -0.9 -1.6 -1.5
Impedance of leg (left) 2.0 9.9 17.7 2.9 3.5 3.5 2.8 3.1 3.7 3.4 3.0 3.0 3.4 2.8 3.4 -3.6 3.7 3.4 0.1 2.4 1.6 3.2 1.0 1.8 3.1 3.1 4.1 4.1 2.8 3.4 4.2 3.8
Leg predicted mass (left) 0.4 2.1 7.3 -1.1 -0.8 -1.1 -1.1 -2.1 -1.8 -1.4 -1.5 -1.0 -0.7 -1.1 -1.4 1.1 -1.4 -1.2 -0.7 -0.0 -2.5 -1.1 -0.1 -0.2 -2.1 -2.7 -2.1 -1.6 -1.6 -1.4 -2.3 -0.8
Trunk fat mass 0.1 0.5 1.7 0.1 0.5 1.3 0.1 -0.9 -0.7 0.7 -0.2 0.6 0.3 0.1 -0.2 -0.4 0.5 0.5 0.3 1.2 -0.8 0.5 1.1 1.2 -0.7 -1.3 -0.6 -0.2 -0.1 0.6 -0.6 0.4
Waist circumference 0.1 0.3 2.0 0.3 0.3 1.1 0.5 0.1 -0.3 0.7 0.1 0.5 -0.2 0.3 -0.0 -0.0 0.3 0.4 1.0 1.1 -0.4 0.5 1.4 1.4 -0.1 -0.3 -0.6 -0.0 -0.5 0.3 -0.3 0.1
Number of incorrect matches in round 0.2 0.4 2.6 0.2 0.8 0.9 0.5 1.6 0.9 0.9 0.2 0.5 0.5 0.2 0.1 -0.6 0.6 0.6 0.2 0.2 0.9 0.8 0.2 0.2 0.2 -0.1 0.4 0.5 0.2 0.4 0.6 0.5
Past tobacco smoking 1.2 2.3 4.8 -1.6 -0.7 -2.2 -1.5 -0.5 -1.2 -1.7 -1.6 -1.8 -0.9 -1.6 -1.4 1.3 -1.5 -1.7 -2.0 -1.8 -1.4 -1.4 -2.2 -2.0 -1.6 -1.5 -0.8 -1.7 -0.1 -1.1 -1.7 -1.3
Alcohol usually taken with meals 0.4 0.7 3.3 -0.6 0.1 -1.1 -0.5 1.8 -0.4 -0.4 -0.8 -0.6 -0.5 -0.6 -0.9 0.6 -0.6 -0.6 -0.0 -0.0 0.4 -0.1 0.3 -0.0 -1.1 -1.4 -1.0 -1.1 -1.7 -0.7 -1.2 -0.6
Nervous feelings 0.3 0.5 3.2 -0.7 -0.7 -1.8 -0.7 1.0 -0.0 -1.6 -0.5 -1.0 0.0 -0.7 0.1 0.1 -0.4 -0.6 -0.8 -0.8 -0.9 -0.2 -1.1 -0.7 -0.1 0.4 0.6 0.8 -0.2 -0.1 0.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.7 -1.0 -0.9 -1.0 -0.7 -0.6 -1.0 -1.3 -1.0 -1.1 -0.1 -1.0 -0.5 0.5 -0.7 -0.9 -0.3 -0.7 -0.7 -0.6 -0.6 -0.8 -1.0 -0.9 -0.8 -1.0 -0.5 -0.5 -0.9 -0.4
Hearing difficulty/problems with background noise 0.3 0.4 2.3 0.4 0.1 1.5 0.4 0.4 -0.0 1.5 0.5 0.7 0.1 0.4 0.1 -0.3 0.3 1.4 0.3 0.6 1.3 0.6 0.9 0.2 0.3 -0.1 -0.6 -0.1 0.4 -0.5 -0.0 -0.1
Hair/balding pattern: Pattern 2 0.5 0.6 1.7 0.6 0.9 1.1 0.7 -0.8 0.1 1.1 0.6 0.6 0.9 0.7 1.1 -1.3 0.9 1.0 -0.2 0.6 -0.2 0.8 0.4 0.4 0.6 0.7 0.8 0.8 0.2 0.6 0.8 0.9
Had menopause 0.6 0.8 2.0 -1.1 -0.7 -1.0 -0.9 -0.1 -0.5 -0.6 -1.0 -1.2 -1.0 -1.1 -1.0 0.9 -1.1 -1.3 -0.4 -1.3 -0.8 -1.0 -0.9 -0.8 -0.8 -0.4 -0.4 -0.1 -1.4 -0.6 -0.6 -0.7
Had other major operations 0.6 0.8 8.3 0.6 0.3 0.0 0.7 2.9 1.1 0.8 0.7 0.1 0.6 0.5 0.8 -0.7 0.6 0.6 -0.1 0.1 1.0 0.5 -0.3 0.3 0.8 0.9 0.5 1.8 -0.4 0.1 1.3 1.1
Forced vital capacity (FVC) 0.2 0.8 3.6 -0.1 1.0 -0.5 -0.0 -0.9 0.1 -1.3 -0.3 0.4 1.6 -0.1 0.6 -0.8 0.5 -0.2 -1.9 0.6 -1.8 -0.0 -0.5 -0.2 -0.9 -1.5 0.8 0.5 0.9 0.8 -0.1 1.5
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 4.0 -1.5 -2.0 -1.2 -1.8 -1.2 -1.9 -1.3 -1.6 -1.9 -1.9 -1.6 -1.6 1.8 -1.8 -1.6 -0.7 -1.6 -1.1 -1.6 -1.4 -1.1 -1.6 -1.7 -1.9 -0.9 -2.0 -1.6 -1.5 -1.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.1 0.4 0.7 0.3 0.5 0.9 1.0 -0.3 0.3 0.4 -0.4 0.3 0.3 0.4 0.2 0.3 1.4 0.3 1.4 0.4 1.1 1.1 0.5 0.8 1.1 0.7 0.2 1.4 0.6 0.1
Qualifications: None of the above 0.1 0.2 1.5 -0.1 -0.5 0.6 0.2 -0.2 -0.3 -0.3 -0.0 0.0 -0.3 -0.1 0.2 0.6 -0.2 -0.3 1.2 0.1 1.2 0.1 0.4 0.4 0.3 0.5 0.2 -0.5 0.1 0.5 -0.1 -0.5
Financial difficulties in last 2 years 0.2 0.3 0.9 -0.2 -0.0 0.5 0.0 -0.3 -0.2 -0.1 -0.3 -0.3 -0.9 -0.2 -0.7 0.7 -0.5 -0.5 0.9 -0.0 1.0 -0.4 0.8 0.2 -0.4 -0.4 -0.8 -0.9 -0.8 -0.4 -0.9 -0.9
Mouth/teeth dental problems 0.4 0.6 2.0 0.9 0.8 0.3 0.4 1.1 0.8 0.5 0.8 0.4 0.6 0.8 0.4 -0.6 0.8 0.7 -0.4 0.7 0.2 1.1 -0.1 0.9 0.7 0.7 1.1 1.4 -0.3 1.0 1.1 1.0
Heart attack 0.4 0.5 2.0 0.7 0.2 0.8 0.6 -1.1 0.5 -0.3 0.6 0.6 0.7 0.7 0.7 -0.9 0.4 0.1 0.8 0.6 -0.0 0.4 0.6 0.6 0.7 0.9 1.3 0.1 1.1 1.4 0.5 0.5
Allergy 0.1 0.2 1.5 0.1 -0.3 0.2 -0.3 -1.0 -0.1 -0.0 0.0 -0.2 -0.1 0.1 -0.3 0.2 -0.2 -0.1 -0.6 -0.2 -1.2 -0.0 -0.4 -0.4 -0.1 -0.2 -0.0 -0.9 0.7 0.1 -0.4 -0.5
Pain all over the body in last month 0.2 0.2 0.9 0.2 0.4 0.1 -0.0 -0.7 -0.1 -0.2 0.0 0.3 -0.0 0.2 0.1 0.3 0.1 0.2 0.6 0.7 0.3 0.6 0.9 0.9 -0.2 -0.4 0.1 -0.2 0.2 0.6 -0.4 0.0
Diabetes (self-reported) 4.0 6.1 12.5 2.7 2.2 2.3 2.5 2.5 2.4 2.8 2.6 2.8 1.4 2.6 1.7 -1.7 2.6 2.6 3.5 2.5 2.6 2.3 3.0 3.4 2.8 2.9 1.5 2.0 1.1 2.6 2.3 1.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.9 0.7 0.9 -0.0 0.4 1.3 0.4 0.7 0.8 0.7 0.3 0.7 0.7 -0.1 0.7 0.8 1.4 0.6 0.8 0.7 0.9 1.0 1.0 0.8 0.3 0.6 -0.2 0.4 0.8 0.4
Medication: Ramipril 1.3 1.7 4.7 1.4 0.8 1.7 1.4 1.0 1.2 1.3 1.4 1.1 1.4 1.3 1.4 -1.7 1.3 1.0 0.6 1.5 0.5 1.4 1.3 1.5 1.4 1.4 0.5 2.2 -0.6 0.3 1.7 1.9
Medication: Simvastatin 1.4 2.1 3.8 1.7 1.2 1.2 1.5 0.6 1.3 0.9 1.8 1.6 1.5 1.7 1.4 -1.0 1.6 1.5 1.2 1.5 1.3 1.5 1.2 1.7 1.8 1.4 1.0 2.0 1.0 1.2 1.9 1.7
Fluid intelligence score 0.5 1.1 3.1 1.1 1.3 0.6 1.2 1.8 1.2 1.0 1.0 1.1 1.1 1.1 0.6 -1.2 1.1 1.0 -0.4 1.0 -0.1 1.0 -0.0 0.8 0.7 0.4 1.5 1.3 1.3 1.6 0.9 1.3
Illnesses of siblings 0.7 1.0 2.2 1.1 1.3 -0.0 0.7 1.4 1.4 0.7 0.9 0.6 1.1 1.0 0.8 -0.8 0.7 1.1 0.2 1.2 -0.3 1.5 1.2 1.2 0.5 0.3 1.3 1.5 -0.4 1.0 1.0 1.5
Neuroticism score 0.3 0.6 1.6 -0.9 -0.6 -0.6 -0.7 -0.6 -0.6 -1.1 -1.0 -1.0 0.3 -1.0 -0.5 -0.1 -0.4 -0.8 -1.1 -0.8 -1.2 -0.4 -1.3 -1.0 -1.0 -0.6 0.3 -0.1 0.6 0.3 -0.4 0.3
Weight 0.2 1.0 4.3 -0.6 -0.3 0.1 -0.6 -1.5 -1.4 -0.6 -0.9 -0.3 -0.5 -0.6 -1.0 0.6 -0.6 -0.4 -0.0 0.7 -1.8 -0.3 0.7 0.7 -1.4 -2.1 -1.7 -1.0 -1.2 -0.6 -1.6 -0.4
Impedance of arm (right) 2.2 10.1 21.8 2.5 3.7 2.8 3.0 4.5 3.2 3.5 2.5 2.7 4.7 2.5 3.5 -4.7 3.9 3.1 -1.9 2.2 0.5 3.3 -0.3 0.8 1.9 1.4 4.0 3.9 3.1 3.5 3.6 4.7
Arm fat percentage (right) 0.2 0.6 2.4 0.6 0.6 1.5 0.6 0.0 -0.3 1.2 0.4 0.9 0.3 0.6 0.1 -0.5 0.9 0.9 1.0 1.4 0.3 0.9 1.5 1.6 0.1 -0.5 -0.6 0.3 -0.1 0.6 -0.1 0.5
Trunk fat-free mass 0.3 1.9 8.5 -0.8 -1.1 -1.4 -0.8 -1.4 -1.3 -1.8 -1.1 -0.9 -0.8 -0.9 -1.1 1.2 -1.5 -1.3 -0.7 0.1 -2.9 -0.9 -0.0 0.1 -1.6 -2.2 -1.9 -1.1 -2.1 -1.7 -1.9 -0.7
Hip circumference 0.1 0.4 2.8 -0.1 0.2 0.4 -0.2 -0.5 -0.8 0.2 -0.4 0.1 0.2 -0.1 -0.6 -0.2 0.3 0.2 -0.5 0.9 -1.4 0.3 0.5 0.8 -1.0 -1.7 -1.2 -0.2 -1.0 -0.2 -0.8 0.4
Time employed in main current job 0.2 0.2 1.0 -0.1 0.5 0.1 -0.2 -0.4 -0.4 -0.0 -0.2 0.1 -0.2 -0.2 -0.2 0.2 0.0 0.0 0.6 0.5 1.0 0.1 0.9 0.4 -0.4 -0.7 -0.9 -0.5 -1.0 -0.7 -0.4 -0.3
Alcohol intake versus 10 years previously 3.9 5.9 13.4 2.9 2.7 3.7 2.9 0.3 2.3 2.6 2.7 2.6 1.4 2.9 2.3 -1.9 2.1 2.5 2.8 2.9 1.9 2.6 3.6 3.2 2.5 2.1 1.4 2.2 0.2 1.7 2.0 1.8
Father’s age at death 0.2 0.3 1.8 -0.3 -0.9 -0.9 -0.1 1.3 -0.1 -0.6 -0.2 -0.4 0.0 -0.3 -0.2 0.6 -0.6 -0.7 -0.4 -0.6 0.0 -0.4 -0.8 -0.3 -0.2 -0.2 0.1 0.4 -1.0 -0.0 0.3 0.2
Worrier / anxious feelings 0.6 1.1 2.1 1.1 0.6 0.9 1.0 0.6 1.2 1.0 1.0 0.7 1.1 1.1 1.1 -1.1 0.9 0.9 0.5 1.3 -0.3 1.4 1.1 1.2 0.8 0.8 1.4 1.3 0.8 1.4 1.0 1.3
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 3.0 -1.5 -1.3 -1.1 -1.5 -1.7 -1.2 -1.7 -1.5 -1.3 -0.8 -1.5 -1.4 1.2 -1.4 -1.2 -0.8 -1.1 -1.3 -1.2 -0.6 -1.2 -1.5 -1.6 -1.1 -1.5 -0.2 -0.8 -1.6 -1.1
Falls in the last year 1.6 2.1 7.0 1.4 1.5 0.6 1.6 2.6 1.8 1.5 1.4 1.2 0.8 1.4 0.9 -1.1 1.3 1.2 1.5 1.5 1.2 1.5 1.8 1.8 1.4 1.3 1.4 2.0 0.9 1.7 1.5 1.4
Hair/balding pattern: Pattern 3 0.3 0.5 1.4 0.8 0.8 0.5 0.6 1.0 1.1 1.1 0.6 0.5 0.7 0.8 0.0 -0.6 0.5 0.7 0.6 1.2 0.4 1.0 1.0 1.1 0.3 -0.2 -0.2 0.2 -0.4 0.3 0.0 0.6
Number of live births 1.3 1.9 4.2 -1.3 -2.0 -1.1 -1.5 -2.0 -1.6 -1.4 -1.3 -1.5 -1.8 -1.3 -1.3 1.5 -1.7 -1.7 0.1 -1.7 0.6 -1.7 -0.8 -0.9 -1.0 -0.4 -0.8 -1.5 -0.6 -0.5 -1.3 -1.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 2.5 -0.0 1.0 0.1 0.0 -1.2 0.0 -0.8 -0.3 0.4 1.1 -0.0 0.2 -0.5 0.4 -0.1 -1.5 0.6 -1.6 0.0 -0.3 -0.2 -0.8 -1.4 0.4 -0.0 0.9 0.5 -0.4 0.9
Pulse rate 0.3 0.5 2.0 0.7 0.3 0.4 0.6 0.6 0.6 0.2 0.7 1.2 0.5 0.7 0.9 -0.3 0.6 0.9 0.6 1.1 0.0 0.7 1.4 1.0 0.7 0.7 0.5 0.8 0.6 0.5 0.7 0.7
Happiness 0.4 0.4 2.0 -0.5 -0.8 -0.5 -0.9 -1.4 -1.0 -0.9 -0.5 -0.4 0.4 -0.6 -0.0 0.2 -0.4 -0.5 -0.9 -0.4 -1.2 -0.3 -0.9 -0.6 -0.6 -0.8 -0.1 -0.7 0.2 0.1 -0.3 -0.1
Noisy workplace 0.1 0.2 2.9 0.2 -0.1 0.1 0.5 -0.7 0.0 -0.2 0.2 -0.1 0.2 0.3 0.0 -0.2 -0.1 -0.1 0.3 0.4 -1.7 -0.1 0.7 0.2 0.1 0.1 -0.2 -0.1 -0.7 -0.3 -0.1 0.1
Qualifications: A levels/AS levels or equivalent 1.9 4.2 10.4 2.3 1.7 1.1 1.9 2.5 2.4 1.8 2.2 1.9 2.5 2.3 2.2 -2.4 2.2 2.3 -1.1 2.1 -1.0 2.2 0.1 1.7 1.6 0.9 1.9 3.2 1.8 1.8 2.5 3.0
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 3.6 0.7 0.3 0.3 0.6 1.9 0.7 0.7 0.8 0.4 0.3 0.7 0.5 -0.3 0.3 0.5 0.3 0.3 0.7 0.4 0.3 0.2 0.8 0.6 -0.3 0.1 -1.3 -0.7 0.6 0.0
Mouth/teeth dental problems: Dentures 0.2 0.4 3.5 0.2 0.0 0.3 0.1 -0.3 0.2 0.4 0.3 0.6 -0.6 0.3 -0.3 0.5 -0.1 0.3 1.9 0.4 0.5 0.2 1.5 0.8 0.6 0.7 -0.2 -0.8 0.7 0.1 -0.3 -0.8
Asthma 0.2 0.3 2.7 -0.2 0.1 -0.3 0.2 1.6 0.2 0.2 -0.2 -0.2 0.2 -0.2 -0.2 -0.6 -0.1 0.1 -0.9 0.3 -0.1 0.1 0.2 -0.0 -0.3 -0.4 -0.3 1.3 -1.4 -1.0 0.3 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 2.3 0.6 0.9 1.5 1.1 0.2 0.3 0.8 0.6 0.8 1.4 0.6 0.9 -1.3 1.0 0.8 -0.2 1.0 -0.6 0.9 0.5 0.2 0.5 0.2 0.5 0.1 0.4 0.5 0.4 0.9
Medication: Cholesterol lowering 1.4 2.2 7.9 1.6 1.6 0.7 1.4 1.2 1.3 1.2 1.4 1.3 1.0 1.5 1.0 -1.1 1.4 1.4 2.6 2.0 2.2 1.7 2.8 2.4 1.4 1.1 0.4 0.9 -0.7 1.0 0.9 1.1
Depression (self-reported) 0.2 0.2 2.8 -0.4 -0.7 -0.0 -0.5 -0.6 -0.5 -0.3 -0.4 -0.6 -0.0 -0.4 -0.0 -0.2 -0.5 -0.4 0.6 -0.2 0.7 -0.2 0.5 -0.0 -0.3 -0.2 -0.0 0.1 -1.7 0.0 -0.0 0.1
Medication: Lansoprazole 0.5 0.5 2.5 -0.7 -0.3 -1.6 -1.0 -0.5 -0.8 -0.4 -0.6 -0.5 -0.2 -0.7 -0.7 0.4 -0.3 -0.3 -0.2 -0.6 -1.1 -0.5 -0.2 -0.9 -0.5 -0.8 -0.8 -1.2 -0.2 -0.9 -0.7 -0.7
Prospective memory result 0.5 0.6 2.8 0.6 1.1 1.2 0.8 -0.6 0.7 0.7 0.5 0.6 0.5 0.6 1.0 -0.8 0.8 0.6 0.2 0.6 0.0 0.6 0.5 0.4 0.5 0.6 1.3 0.1 1.7 1.4 0.4 0.4
Lung cancer (father) 3.4 3.9 6.8 -2.2 -2.1 -1.2 -1.7 -2.5 -2.3 -2.0 -2.3 -2.2 -1.5 -2.2 -1.3 1.2 -2.2 -2.6 -2.5 -2.1 -2.2 -2.4 -2.5 -2.2 -2.2 -1.6 -0.9 -2.0 -0.0 -1.1 -2.2 -1.7
Illnesses of mother 0.6 0.7 2.8 1.0 0.7 0.7 0.6 -0.4 0.6 1.3 1.1 1.1 0.9 1.0 1.7 -1.1 1.0 1.0 -0.3 0.6 -1.0 0.6 0.2 -0.0 1.2 1.1 0.4 -0.2 0.9 -0.3 0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 2.9 0.0 0.8 -0.2 -0.1 -0.5 -0.1 -0.9 -0.1 0.3 1.0 0.0 -0.0 -0.2 0.4 0.0 -1.4 0.6 -1.7 0.3 -0.4 -0.1 -0.7 -1.5 -0.1 0.0 0.5 0.0 -0.2 0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.8 0.1 0.3 -0.6 0.1 0.6 0.6 0.2 0.2 0.2 0.2 0.1 0.2 -0.4 0.4 -0.1 -0.3 0.0 -0.9 -0.0 -0.1 -0.2 0.2 0.3 -0.2 -0.3 0.2 -0.4 -0.0 -0.0
Impedance of arm (left) 1.8 8.5 18.4 2.3 3.4 2.9 2.6 3.2 2.8 3.4 2.3 2.5 4.2 2.3 3.3 -4.3 3.6 3.0 -1.8 2.0 0.3 3.0 -0.3 0.6 1.8 1.4 3.9 3.2 3.5 3.4 3.2 4.0
Arm fat mass (right) 0.1 0.4 1.6 -0.0 -0.0 0.8 -0.1 -1.0 -1.0 0.2 -0.3 0.3 -0.2 -0.1 -0.5 0.2 0.0 0.2 0.6 0.9 -0.7 0.1 1.1 1.1 -0.7 -1.2 -1.3 -0.5 -0.6 -0.2 -0.9 -0.2
Trunk predicted mass 0.3 1.9 8.8 -0.9 -1.1 -1.4 -0.8 -1.3 -1.3 -1.7 -1.1 -0.9 -0.8 -0.9 -1.1 1.1 -1.6 -1.3 -0.7 0.1 -3.0 -0.9 -0.0 0.1 -1.6 -2.2 -1.9 -1.1 -2.1 -1.7 -1.9 -0.7
Standing height 0.2 1.9 11.9 0.3 1.5 0.2 0.7 1.3 0.9 -0.0 -0.1 0.4 2.5 0.3 1.1 -1.9 0.7 0.5 -2.9 1.4 -3.5 0.9 -0.7 0.1 -1.1 -2.0 1.0 1.4 -0.4 0.5 0.2 2.6
Length of working week for main job 1.0 1.1 5.4 -1.0 -1.0 -0.9 -0.6 -0.1 -0.7 -1.9 -0.9 -1.2 0.1 -1.0 -0.1 0.2 -0.9 -1.4 -2.3 -1.1 -1.9 -0.9 -2.0 -1.5 -0.9 -0.7 0.1 0.5 0.2 -0.6 -0.2 0.3
Exposure to tobacco smoke at home 0.5 0.5 1.7 -0.3 -0.3 0.2 -0.3 -0.5 -0.6 0.1 -0.4 0.2 -1.0 -0.3 -0.8 1.2 -0.4 -0.0 1.2 0.3 0.7 0.1 1.0 0.5 -0.4 -0.8 -1.3 -1.3 0.6 -0.5 -1.2 -1.2
Breastfed as a baby 0.5 0.6 1.5 0.8 1.0 0.8 1.1 0.9 0.8 0.9 0.9 0.9 0.8 0.8 1.2 -0.6 0.8 0.8 0.4 0.8 0.9 0.5 0.4 0.6 0.9 0.6 0.5 1.0 0.3 0.3 0.9 0.9
Tense / ‘highly strung’ 0.5 0.8 1.8 -1.2 -0.6 -1.0 -1.1 -0.6 -1.1 -1.3 -1.2 -1.4 -0.6 -1.3 -0.7 0.7 -0.9 -0.9 -0.5 -0.9 0.6 -0.8 -0.6 -0.9 -1.0 -0.8 -0.8 -0.5 -1.0 -1.1 -0.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.8 -0.1 -0.5 -0.1 -0.0 -0.9 -0.4 -0.4 -0.1 -0.5 0.3 -0.2 0.1 -0.3 -0.2 -0.4 -0.4 -0.3 0.2 -0.3 -0.5 -0.5 -0.1 -0.0 0.2 -0.0 -0.4 -0.0 0.1 0.1
Hair/balding pattern: Pattern 4 1.5 3.6 6.8 -2.3 -2.1 -1.5 -1.8 -1.0 -2.0 -2.6 -2.2 -1.8 -1.5 -2.3 -1.9 1.9 -2.1 -2.2 -1.3 -1.8 -0.5 -1.9 -1.4 -2.1 -2.1 -2.1 -2.1 -1.6 -1.6 -2.5 -2.0 -1.5
Birth weight of first child 2.5 4.6 8.2 2.3 2.8 2.2 2.3 2.9 2.7 2.7 2.2 2.3 1.4 2.3 1.6 -1.6 2.1 2.7 1.6 2.4 2.3 2.9 2.2 2.7 2.1 1.6 1.4 1.7 0.5 1.6 1.8 1.6
Peak expiratory flow (PEF) 0.5 1.1 3.1 1.0 1.7 1.6 1.3 -0.2 1.1 0.5 0.9 1.4 1.8 1.1 1.1 -1.3 1.5 0.9 -0.4 1.3 -0.7 0.8 0.3 0.4 0.5 -0.1 0.6 0.5 1.7 0.8 0.6 1.3
Pulse wave reflection index 0.2 0.2 1.1 -0.2 0.4 -0.4 -0.5 -0.6 0.2 -0.0 -0.2 -0.1 -0.7 -0.2 -0.2 0.6 0.1 -0.4 0.4 -0.5 0.4 -0.5 -0.2 -0.3 -0.1 -0.1 -0.2 -1.0 0.8 0.1 -0.4 -1.0
Ever highly irritable/argumentative for 2 days 2.6 3.2 13.6 1.6 1.7 2.7 1.7 0.7 1.7 1.1 1.5 2.0 0.3 1.6 1.1 -0.5 1.6 1.9 2.4 1.9 3.7 1.6 2.4 2.7 1.6 1.6 1.2 1.5 1.2 2.0 1.4 0.9
Loud music exposure frequency 0.4 0.4 3.1 0.2 0.8 1.0 0.2 -1.8 -0.2 -0.2 -0.1 0.4 0.4 0.1 0.0 -0.3 0.6 0.4 0.6 0.9 0.6 0.4 1.2 0.9 -0.3 -0.7 -0.3 -0.1 0.5 0.4 -0.3 0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 0.8 0.6 -0.1 0.2 0.4 0.9 0.2 0.6 0.4 0.8 0.7 0.4 -0.8 0.4 0.8 -0.4 0.9 -0.9 0.8 0.2 0.8 0.2 -0.1 0.8 0.7 0.0 0.7 0.4 0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 -0.0 0.4 0.5 0.6 -0.7 0.1 -0.3 0.0 -0.2 0.7 0.1 0.9 -0.8 0.1 -0.3 -0.9 -0.2 -0.4 -0.6 -0.6 -0.8 -0.1 -0.1 0.6 0.3 0.3 0.1 0.1 0.5
Blood clot in the leg (DVT) 0.1 0.1 0.6 -0.3 -0.2 0.1 -0.3 -0.6 -0.1 -0.0 -0.4 -0.0 -0.2 -0.3 -0.4 0.1 -0.2 0.0 -0.0 0.0 -0.7 -0.1 0.1 0.2 -0.5 -0.7 -0.2 0.6 0.0 0.0 -0.2 0.3
Medication: Paracetamol 0.1 0.2 1.0 -0.6 -0.1 -0.4 -0.4 -0.2 -0.6 -0.2 -0.5 -0.1 0.2 -0.6 -0.2 -0.3 -0.1 -0.2 -1.0 -0.4 -0.5 -0.6 -0.5 -1.0 -0.4 -0.6 -0.2 -0.3 0.5 -0.7 -0.3 -0.1
Headache pain in last month 1.2 2.1 4.6 -1.5 -0.9 -1.7 -1.6 -0.9 -1.2 -1.1 -1.3 -1.6 -2.0 -1.5 -1.8 1.9 -1.4 -1.4 0.7 -1.7 -0.2 -1.7 -0.3 -0.9 -0.9 -0.6 -2.1 -1.1 -1.8 -2.1 -1.3 -1.8
Medication for cholesterol, blood pressure or diabetes 3.1 5.2 9.2 -2.5 -2.7 -1.7 -2.3 -2.4 -2.2 -1.9 -2.5 -2.2 -2.0 -2.5 -2.0 2.0 -2.4 -2.5 -2.4 -3.0 -1.7 -2.9 -3.0 -3.0 -2.4 -2.0 -1.5 -2.0 -0.4 -1.6 -2.2 -2.1
Glaucoma (self-reported) 0.5 0.6 3.3 -0.3 -0.6 -0.2 -0.3 0.1 -0.2 0.2 -0.3 -0.3 -1.8 -0.4 -0.7 1.2 -0.8 -0.2 1.8 -0.4 1.4 -0.7 0.9 0.8 -0.0 0.4 -0.1 -0.1 -0.9 0.3 -0.3 -1.1
Gout (self-reported) 1.0 1.4 4.9 1.2 1.1 1.9 1.1 1.1 0.8 1.4 1.2 1.3 0.6 1.1 0.7 -0.6 1.3 1.3 1.8 1.4 2.2 1.3 1.4 1.5 1.2 0.9 0.2 0.1 -0.1 0.9 0.8 0.3
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 6.1 -0.0 -0.0 -0.2 0.6 2.5 1.1 -0.1 -0.1 -0.4 1.1 -0.1 0.0 -1.2 0.1 -0.5 -1.7 -0.0 -1.2 0.1 -1.0 -0.3 -0.4 -0.2 1.3 1.8 -0.5 0.8 0.8 1.7
Medication: Amlodipine 0.2 0.3 1.0 -0.6 0.1 -1.0 -0.4 0.0 -0.5 -0.9 -0.5 -0.4 -0.1 -0.6 -0.9 0.5 -0.0 -0.6 -0.4 -0.5 -0.6 -0.2 -0.5 -0.6 -0.5 -0.6 -0.6 -0.4 0.6 -0.6 -0.4 -0.2
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.9 1.4 0.7 1.1 1.5 1.0 0.9 0.9 1.3 1.7 1.5 1.4 1.7 -1.6 1.2 1.0 0.3 1.7 0.1 1.2 1.0 1.2 1.1 1.0 0.8 1.3 0.8 0.7 1.2 1.5
Birth weight 2.7 5.9 12.5 2.2 2.6 2.9 3.0 3.5 2.9 3.0 2.2 2.4 2.8 2.2 2.6 -3.1 2.5 2.5 0.0 2.3 1.4 2.5 0.9 1.6 2.0 1.7 2.8 2.7 1.4 2.3 2.6 2.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 2.4 0.2 0.1 0.3 0.8 0.8 0.1 -0.7 0.2 0.4 0.7 0.2 0.5 -0.1 0.4 -0.5 -0.7 0.2 -0.2 0.0 -0.8 -0.3 0.1 -0.0 1.5 0.8 1.5 1.5 0.6 0.8
High blood pressure (siblings) 0.4 0.5 1.7 -0.7 -1.1 -0.2 -0.6 -0.8 -1.2 -0.7 -0.6 -0.5 -0.5 -0.7 -0.6 0.7 -0.3 -0.6 -0.1 -0.8 0.4 -0.9 -1.0 -0.9 -0.4 -0.4 -0.9 -1.3 0.8 -0.5 -0.6 -1.0
Forced vital capacity (FVC), Best measure 0.2 0.7 5.3 0.2 1.1 -0.5 0.0 -0.6 0.1 -1.1 0.1 0.6 1.6 0.2 0.4 -0.6 0.7 0.2 -1.8 0.8 -2.3 0.5 -0.5 -0.1 -0.6 -1.5 0.1 0.3 0.7 0.1 0.1 1.3
Body fat percentage 0.2 0.8 3.6 0.7 0.8 1.9 0.6 -0.4 -0.2 1.4 0.4 1.1 0.4 0.7 0.2 -0.6 1.1 1.2 1.1 1.5 0.5 1.0 1.7 1.7 0.2 -0.2 -0.2 0.4 0.4 1.0 0.1 0.6
Leg fat percentage (right) 0.5 1.9 6.0 1.4 0.9 2.4 1.2 0.2 0.6 1.6 1.3 1.7 0.2 1.3 0.7 -0.5 1.4 1.6 2.4 1.8 1.6 1.4 2.5 2.4 1.4 1.1 -0.1 1.1 0.1 0.9 1.0 0.6
Arm fat-free mass (right) 0.7 3.8 9.3 -1.5 -1.6 -1.5 -1.7 -3.0 -2.1 -2.2 -1.8 -1.6 -1.8 -1.5 -2.0 2.1 -2.2 -1.8 -0.5 -0.5 -2.8 -1.6 -0.1 -0.3 -2.2 -2.6 -2.6 -2.1 -2.2 -2.1 -2.8 -1.8
Exposure to tobacco smoke outside home 0.5 0.7 2.6 -0.7 -0.6 0.1 -0.6 -1.6 -1.0 -0.1 -0.9 -0.6 -0.9 -0.7 -0.5 0.6 -0.7 -0.7 -0.3 -0.3 -0.9 -0.7 -0.4 -0.4 -1.1 -1.0 -0.4 -1.4 0.9 0.1 -1.5 -1.0
Comparative body size at age 10 2.6 7.1 30.5 -2.4 -2.3 -2.2 -2.0 -3.0 -2.6 -3.0 -2.3 -2.8 0.4 -2.4 -1.3 0.4 -1.8 -2.7 -5.0 -2.5 -5.5 -2.1 -4.0 -4.1 -2.8 -3.1 -1.4 -1.2 0.0 -2.4 -1.8 -0.2
Number of full brothers 0.1 0.1 0.3 0.3 -0.4 0.2 0.5 0.3 0.1 -0.4 0.4 0.2 -0.3 0.3 -0.2 0.4 -0.0 -0.2 0.2 0.1 -0.5 0.0 0.1 0.3 0.4 0.3 -0.5 0.5 -0.1 -0.5 0.3 -0.0
Worry too long after embarrassment 0.6 1.0 7.5 -0.2 0.0 -0.2 0.1 0.9 0.1 0.1 -0.2 -0.3 1.2 -0.2 0.3 -1.3 0.2 -0.0 -2.7 -0.4 -2.7 0.0 -2.1 -1.4 -0.4 -0.4 1.0 0.4 1.0 0.2 0.3 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 5.8 -1.7 -1.5 -2.4 -1.6 0.4 -1.2 -1.6 -1.6 -1.9 -0.8 -1.7 -1.4 1.1 -1.6 -1.5 -1.1 -1.7 -0.5 -1.3 -1.4 -1.8 -1.6 -1.6 -1.2 -0.7 -1.9 -1.5 -1.1 -0.7
Wheeze or whistling in the chest in last year 0.4 0.7 2.3 0.5 0.1 0.3 1.0 1.3 0.5 0.8 0.3 0.9 1.1 0.4 0.5 -1.5 0.5 1.1 -0.2 1.2 0.2 0.8 1.0 0.7 -0.0 -0.2 0.9 1.3 0.6 0.8 0.6 1.4
Number of children fathered 2.0 2.2 4.4 -1.6 -1.7 -1.7 -1.9 -1.9 -1.8 -1.4 -1.6 -1.7 -1.7 -1.6 -1.1 1.4 -1.6 -1.9 -1.3 -1.9 -1.0 -2.1 -1.6 -1.4 -1.4 -0.7 -0.7 -1.0 -0.5 -0.9 -1.4 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.6 1.2 0.9 1.3 0.9 0.8 1.0 0.9 1.4 1.7 0.9 1.2 1.5 -0.5 1.5 1.3 0.8 1.0 1.6 1.3 0.5 1.3 1.5 1.3 1.1 0.6 1.9 1.5 1.4 0.6
Age at first live birth 1.5 2.6 6.1 1.6 2.5 1.8 1.5 1.8 2.3 1.7 1.6 1.9 1.1 1.7 1.4 -1.2 1.8 1.8 1.7 1.7 1.1 1.7 2.0 1.7 1.6 1.4 1.4 0.9 0.7 1.4 1.3 1.0
Pulse wave peak to peak time 0.1 0.2 0.8 -0.3 -0.4 0.5 -0.2 -0.9 -0.8 -0.5 -0.3 -0.4 -0.3 -0.3 -0.3 0.5 -0.5 -0.1 0.0 -0.0 0.5 -0.1 -0.1 0.2 -0.4 -0.7 -0.1 0.2 -0.6 0.2 -0.2 0.0
Health satisfaction 0.2 0.3 1.6 -0.4 -0.6 -0.1 -0.3 -0.4 -0.7 -0.7 -0.5 -0.4 0.2 -0.4 -0.4 0.3 -0.6 -0.5 -0.6 0.2 -0.1 -0.2 0.2 -0.2 -0.8 -1.3 -0.6 0.1 -1.0 -0.7 -0.5 0.3
Shortness of breath walking on level ground 0.2 0.3 1.3 -0.4 -1.1 -0.5 -0.4 -0.2 -0.5 -0.8 -0.3 -0.4 -0.5 -0.4 -0.3 0.6 -0.7 -0.4 -0.3 -0.3 -0.7 -0.4 -0.2 -0.3 -0.2 -0.1 -0.8 -0.1 -0.6 -1.1 -0.2 -0.4
Qualifications: College or University degree 1.1 3.5 16.5 -1.7 -1.3 -3.0 -1.7 0.7 -1.0 -1.8 -1.8 -1.9 0.0 -1.8 -1.2 0.5 -1.4 -2.0 -4.1 -1.9 -2.3 -1.7 -3.1 -2.3 -2.3 -2.6 -0.5 0.9 -1.4 -1.3 -0.7 0.7
Eye problems/disorders: None of the above 0.3 0.3 2.5 0.3 0.5 0.9 0.4 0.1 0.3 0.4 0.2 -0.3 0.9 0.3 0.3 -0.9 0.5 0.1 -1.6 0.2 -0.8 0.6 -1.0 -0.4 -0.2 -0.6 0.2 0.3 0.2 0.0 0.3 0.7
Mouth/teeth dental problems: Loose teeth 0.7 0.9 5.8 0.1 -0.0 -0.0 -0.6 -1.7 -0.1 0.1 0.1 -0.1 -0.9 0.1 -0.2 0.7 -0.1 -0.4 2.4 -0.2 1.1 -0.7 1.6 0.7 0.5 0.8 -1.2 -0.8 -2.3 -0.7 -0.3 -1.1
Emphysema/chronic bronchitis 0.9 1.0 2.5 1.3 0.5 1.2 1.3 -1.0 0.6 0.6 1.2 1.0 1.0 1.3 1.6 -1.2 0.9 1.0 0.5 1.4 0.0 0.8 1.1 1.0 1.0 1.0 1.0 0.6 0.4 0.9 0.9 0.9
Medication for pain relief, constipation, heartburn 0.1 0.2 0.7 -0.1 0.4 -0.5 -0.6 0.6 0.4 -0.1 -0.2 -0.3 -0.7 -0.2 -0.4 0.7 -0.2 -0.1 -0.2 -0.4 0.8 0.0 -0.4 0.3 -0.2 -0.2 -0.2 0.8 -0.8 -0.1 0.1 0.0
Neck or shoulder pain in last month 0.2 0.2 1.3 -0.2 -1.2 0.1 -0.0 -0.9 -0.5 0.0 -0.1 -0.5 -0.3 -0.2 -0.4 0.1 -0.5 -0.5 -0.3 -0.4 -0.6 -0.7 -0.5 -0.4 -0.0 0.1 -0.7 0.5 -0.4 -0.9 0.0 -0.0
Medication: Blood pressure 2.4 4.3 7.0 2.4 2.5 1.6 2.1 1.4 2.1 1.6 2.4 2.3 2.0 2.4 2.0 -2.0 2.4 2.2 2.0 2.6 0.9 2.6 2.6 2.4 2.5 2.1 1.4 1.8 0.8 1.3 2.2 1.9
Angina (self-reported) 1.0 1.3 7.0 -0.7 -1.2 -0.4 -1.1 -2.6 -1.4 -1.1 -0.9 -0.9 -1.5 -0.7 -1.2 1.3 -1.3 -1.1 0.9 -0.6 0.4 -1.0 0.3 -0.2 -0.9 -0.8 -0.8 -2.0 -0.4 -0.2 -1.6 -1.8
Migraine (self-reported) 1.2 1.5 6.0 -1.1 -0.9 -1.2 -0.8 0.4 -0.5 -1.3 -0.9 -1.5 0.2 -1.1 -0.7 0.1 -0.9 -0.8 -2.0 -1.1 -2.4 -1.0 -1.5 -1.9 -1.1 -1.5 -1.4 -0.1 -1.5 -2.2 -0.5 0.0
Medication: Ibuprofen 0.2 0.2 0.9 0.3 0.6 1.0 0.7 0.3 0.1 0.4 0.3 0.5 0.9 0.3 0.4 -0.8 0.6 0.4 -0.1 0.6 -0.4 0.6 0.2 0.1 0.2 0.1 0.2 -0.3 0.4 0.2 0.1 0.4
Medication: Allopurinol 0.2 0.3 2.0 0.5 0.6 1.4 0.7 0.0 0.2 0.7 0.5 0.7 0.4 0.5 0.4 -0.3 0.6 0.5 0.6 0.5 1.4 0.4 0.5 0.4 0.4 0.2 0.2 -0.4 0.5 0.5 0.1 -0.0
Medication: Omeprazole 0.5 0.6 2.4 -0.6 -1.0 -0.2 -0.7 -1.5 -1.0 -0.6 -0.5 -0.7 -0.5 -0.6 -0.5 0.4 -0.6 -0.6 -0.1 -0.6 -1.6 -0.6 -0.3 -0.8 -0.2 0.0 -0.4 -1.6 0.5 -0.4 -0.6 -1.2
Medication: Seretide 50 evohaler 0.1 0.1 0.8 -0.0 0.0 -0.3 -0.2 -0.7 -0.4 -0.1 -0.1 0.2 0.1 -0.0 0.2 -0.1 0.0 0.2 -0.0 0.5 -0.1 0.1 0.9 0.0 -0.2 -0.3 -0.5 -0.3 0.5 -0.6 -0.4 -0.0
Mean time to correctly identify matches 0.2 0.4 4.4 0.3 0.1 -0.2 0.5 2.1 0.8 0.6 0.3 0.2 0.3 0.3 0.4 -0.4 0.0 0.4 0.4 -0.2 -0.1 0.5 -0.2 -0.2 0.6 0.8 1.3 -0.2 1.1 1.1 0.3 -0.0
Heart disease (mother) 0.2 0.2 1.0 -0.3 0.1 -0.3 -0.2 -0.5 0.2 -0.6 -0.4 -0.2 -0.3 -0.3 -0.6 0.2 -0.2 -0.4 0.4 0.3 1.0 -0.3 0.7 0.5 -0.5 -0.7 -0.4 -0.0 -0.8 0.0 -0.5 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 3.9 1.3 1.3 1.1 1.4 2.0 1.6 1.1 1.3 1.3 0.1 1.3 0.7 -0.7 1.0 0.7 1.5 1.2 0.9 1.3 1.2 1.7 1.4 1.7 1.1 0.9 0.4 1.2 1.1 0.4
Whole body fat mass 0.1 0.5 2.8 0.3 0.4 1.3 0.2 -0.9 -0.6 0.6 -0.0 0.6 0.0 0.2 -0.2 -0.2 0.5 0.6 1.0 1.4 -0.3 0.6 1.7 1.6 -0.4 -0.9 -0.7 -0.1 -0.4 0.4 -0.6 0.2
Leg fat mass (right) 0.2 0.8 4.5 0.6 0.3 1.4 0.4 -0.9 -0.3 0.7 0.4 0.9 -0.3 0.6 0.0 0.0 0.5 0.8 1.8 1.4 0.5 0.6 2.1 2.0 0.3 0.0 -1.0 0.3 -0.9 0.1 -0.1 0.1
Arm predicted mass (right) 0.7 3.4 9.0 -1.4 -1.5 -1.3 -1.6 -3.0 -2.0 -2.0 -1.7 -1.4 -1.8 -1.4 -1.9 2.0 -2.1 -1.6 -0.2 -0.3 -2.5 -1.5 0.2 -0.0 -2.1 -2.5 -2.5 -2.1 -2.2 -1.9 -2.7 -1.7
Pulse rate, automated reading 0.1 0.2 1.9 -0.4 -1.2 -0.6 -0.4 -0.4 -0.3 -0.5 -0.2 0.0 0.4 -0.3 0.5 -0.2 -0.4 -0.2 -0.5 -0.2 -1.4 -0.3 -0.3 -0.3 0.2 0.6 0.3 0.6 0.2 -0.3 0.4 0.5
Alcohol intake frequency. 0.5 1.1 3.3 -0.9 -0.7 -0.0 -0.4 -0.8 -0.5 -0.7 -1.0 -0.8 -1.7 -0.9 -0.9 1.4 -1.3 -1.1 1.4 -0.6 1.8 -1.0 0.9 0.1 -0.6 -0.2 -0.7 -1.8 -0.9 -0.4 -1.4 -1.8
Comparative height size at age 10 0.3 1.8 16.5 -0.2 0.4 0.2 0.2 0.1 -0.1 0.4 -0.3 -0.3 2.1 -0.3 0.9 -2.2 0.5 0.2 -3.5 0.4 -4.1 0.0 -1.7 -1.2 -1.0 -1.5 -0.1 0.8 -0.6 -0.9 0.1 1.8
Number of full sisters 0.3 0.4 2.0 -0.6 -0.4 -0.1 -0.4 -0.1 -0.2 -0.7 -0.6 -0.4 -0.8 -0.6 -0.3 0.7 -0.6 -1.1 0.4 -0.7 1.4 -0.9 -0.1 -0.4 -0.3 0.0 -0.4 -0.3 -1.1 -0.3 -0.4 -0.6
Suffer from ‘nerves’ 0.4 0.7 1.7 -1.1 -0.5 -1.0 -1.1 -1.1 -1.0 -1.2 -1.2 -1.3 -0.6 -1.1 -1.0 0.6 -0.8 -1.0 -0.3 -0.8 -0.1 -0.5 -0.6 -0.5 -1.1 -0.8 0.1 -0.6 0.0 0.3 -0.9 -0.4
Overall health rating 0.1 0.2 0.7 -0.5 -0.9 -0.2 -0.6 -0.9 -0.4 -0.4 -0.5 -0.8 -0.1 -0.5 -0.4 0.1 -0.6 -0.3 -0.2 -0.1 -0.5 -0.3 0.0 -0.2 -0.5 -0.5 -0.4 0.4 -0.8 -0.6 -0.1 0.2
Chest pain or discomfort 0.9 1.3 3.1 -1.2 -1.1 -1.2 -0.9 -0.5 -1.8 -0.5 -1.3 -1.2 -0.9 -1.2 -1.6 0.8 -0.9 -0.8 -0.7 -0.8 0.1 -1.0 -0.9 -1.2 -1.5 -1.8 -1.7 -1.2 0.3 -1.4 -1.5 -1.0
Had major operations 2.5 3.0 5.3 2.2 1.2 1.7 2.2 1.3 1.8 2.2 2.3 2.2 1.8 2.2 1.8 -1.8 1.9 1.9 1.3 2.0 -0.5 1.9 1.3 1.6 2.2 1.7 0.8 0.7 1.4 0.9 1.7 1.1
Age at last live birth 2.3 3.3 5.5 2.0 2.3 2.2 1.7 0.9 2.1 1.9 1.9 2.1 1.3 2.0 1.5 -1.2 2.1 2.0 2.3 2.0 1.2 1.9 2.3 1.9 2.0 1.8 1.7 0.7 1.6 2.0 1.5 1.0
Family relationship satisfaction 0.4 0.5 4.1 -0.3 -0.1 0.2 -0.1 -0.1 -0.6 0.2 -0.2 -0.2 1.3 -0.3 0.3 -1.1 0.0 -0.1 -2.0 -0.1 -1.2 0.2 -1.2 -0.9 -0.6 -0.9 0.4 0.4 -0.6 -0.1 0.3 1.0
Leg pain on walking 0.3 0.3 1.5 0.4 -0.3 0.2 0.4 0.8 0.3 -0.1 0.4 0.6 0.9 0.4 0.6 -0.6 0.6 0.5 -0.5 0.5 -0.5 0.5 -0.1 0.3 0.3 0.1 0.3 1.2 1.0 0.4 0.8 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.9 0.2 -0.5 0.7 0.1 -1.4 -0.5 0.2 0.1 0.1 -0.5 0.2 0.2 -0.1 -0.1 0.1 0.8 0.5 -0.7 -0.1 1.2 0.4 0.1 0.2 -1.1 -0.5 -0.6 -1.0 -0.4 -0.5
Commuting to job workplace: Car/motor vehicle 1.2 1.4 3.4 1.3 1.2 1.7 1.3 1.6 1.3 1.2 1.3 1.3 0.6 1.3 0.8 -0.5 1.1 1.4 1.6 1.1 1.8 1.5 1.6 1.2 1.3 1.0 0.4 0.4 0.4 0.6 0.7 0.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 2.2 0.2 0.5 -0.6 -0.0 0.6 0.3 -0.6 0.2 0.2 0.3 0.2 0.4 0.1 0.5 0.3 -0.5 0.3 0.1 0.5 -0.2 0.2 0.1 -0.1 0.4 1.5 0.8 0.1 0.7 0.9
Medication: Aspirin 0.2 0.3 1.4 -0.0 -0.7 -0.1 -0.2 -1.0 -0.7 -0.3 -0.1 -0.1 -0.4 -0.1 -0.5 0.5 -0.2 -0.2 1.1 0.0 0.4 -0.2 0.5 0.2 -0.2 -0.4 -0.7 -1.2 -0.1 0.1 -0.6 -0.8
Supplements: Vitamin C 1.7 2.0 4.2 1.1 1.4 1.8 1.1 1.4 1.7 1.4 1.1 1.3 2.0 1.2 1.8 -1.9 1.6 1.7 -0.4 1.2 0.3 1.7 0.4 0.3 1.0 0.7 2.0 1.2 2.0 1.8 1.5 1.7
Knee pain experienced in last month 0.7 1.1 3.9 0.9 1.1 1.4 1.5 0.8 1.0 1.4 0.8 1.1 1.6 1.0 1.4 -2.0 1.2 1.1 0.0 1.3 0.8 0.6 1.1 0.4 0.6 0.5 0.9 0.4 0.6 0.9 0.6 1.2
Hypertension (Self-reported) 0.5 1.3 2.8 1.3 1.6 0.9 1.2 0.6 0.7 0.9 1.5 1.3 1.5 1.3 1.2 -0.9 1.7 1.0 1.1 1.6 -0.1 1.5 1.2 1.1 1.5 0.9 -0.2 0.6 -0.1 -0.2 1.2 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 1.4 -0.5 -0.6 -0.5 -0.6 -1.1 -0.5 -0.6 -0.3 -0.5 0.1 -0.5 -0.2 0.1 -0.4 -0.1 -0.9 -0.7 -1.1 -0.5 -0.7 -1.2 -0.2 -0.2 -0.5 -1.2 -0.4 -1.1 -0.4 -0.7
Illnesses of father: Heart disease 0.3 0.4 1.3 -0.4 -0.2 -0.8 -0.4 0.5 -0.2 -0.5 -0.4 -0.8 -1.1 -0.4 -0.7 1.0 -0.7 -0.6 1.1 -0.6 0.8 -0.5 0.5 0.1 -0.2 0.1 0.3 -0.8 -0.4 0.4 -0.5 -1.1
Illnesses of siblings: Diabetes 0.4 0.4 1.8 -0.4 -0.5 0.2 -0.2 -0.9 -0.8 -0.5 -0.5 0.0 -0.8 -0.4 -1.1 1.0 -0.2 -0.5 1.3 -0.2 1.2 -0.6 0.3 0.3 -0.4 -0.5 -0.7 -0.8 0.5 0.6 -0.7 -0.8
Smoking status: Previous 1.2 1.8 4.2 1.4 0.7 2.0 1.4 1.0 1.1 1.7 1.4 1.4 0.9 1.3 1.2 -1.6 1.4 1.4 1.0 1.4 0.9 1.2 1.4 1.5 1.4 1.3 0.7 2.1 -0.4 0.7 1.8 1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 4.1 1.2 1.4 1.2 1.3 0.9 1.2 0.9 1.0 1.4 1.5 1.2 1.2 -1.5 1.2 1.6 -0.1 1.9 0.1 1.4 1.4 1.4 0.5 0.1 0.8 2.0 0.0 0.5 1.0 2.0
Whole body fat-free mass 0.5 2.7 8.5 -1.2 -1.2 -1.4 -1.2 -2.1 -1.8 -1.9 -1.6 -1.2 -1.1 -1.3 -1.5 1.4 -1.8 -1.5 -0.8 -0.2 -2.9 -1.3 -0.2 -0.2 -2.1 -2.6 -2.3 -1.7 -2.0 -1.9 -2.4 -1.1
Leg fat-free mass (right) 0.9 4.7 11.8 -2.0 -1.6 -1.9 -1.9 -2.9 -2.6 -2.3 -2.3 -1.9 -1.4 -2.0 -2.1 1.8 -2.2 -2.2 -1.3 -0.9 -3.1 -2.0 -0.8 -1.0 -2.9 -3.4 -2.7 -2.5 -2.0 -2.1 -3.1 -1.6
Arm fat percentage (left) 0.1 0.4 1.7 0.2 0.1 1.3 0.1 -0.8 -0.9 0.9 -0.0 0.5 -0.2 0.2 -0.3 -0.1 0.4 0.5 0.8 0.9 0.1 0.3 1.1 1.1 -0.3 -0.8 -1.0 -0.4 -0.1 0.1 -0.6 -0.1
Average weekly red wine intake 0.1 0.2 1.8 -0.1 0.2 -0.9 -0.4 1.3 0.5 -0.4 -0.2 -0.4 -0.1 -0.1 -0.2 0.2 -0.1 -0.2 -0.6 -0.1 0.6 0.1 -0.4 0.1 -0.4 -0.5 0.3 0.9 -0.5 0.2 0.2 0.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 5.5 -0.5 -0.1 -1.4 -0.8 0.5 -0.1 -0.7 -0.6 -0.8 -0.9 -0.6 -0.9 1.0 -0.8 -0.5 0.5 -0.2 1.0 -0.1 0.6 0.5 -0.6 -0.8 -0.7 0.0 -2.3 -0.6 -0.5 -0.4
Mood swings 0.1 0.3 3.9 -0.1 0.0 0.3 -0.3 -2.0 -0.6 -0.2 -0.3 -0.4 0.4 -0.2 0.2 -0.4 0.2 -0.1 -0.5 0.2 -0.3 0.2 -0.1 0.2 -0.4 -0.4 0.1 0.8 0.1 0.4 0.1 0.8
Loneliness, isolation 0.5 0.7 1.5 -1.0 -0.6 -0.4 -0.6 -1.1 -1.2 -0.8 -1.0 -0.8 -0.6 -1.0 -0.8 0.5 -0.7 -1.2 -0.3 -0.9 -0.2 -1.0 -0.9 -1.1 -1.0 -0.8 -0.6 -1.0 0.1 -0.5 -1.0 -0.8
Long-standing illness, disability or infirmity 1.6 2.5 7.6 1.1 1.2 0.8 1.3 1.9 1.5 1.8 1.0 0.8 2.2 1.1 1.5 -2.5 1.4 1.3 -1.2 1.4 -0.6 1.4 0.3 0.8 0.7 0.6 2.4 2.7 1.1 2.1 1.9 2.8
Ever had bowel cancer screening 0.1 0.2 1.5 -0.1 -0.4 0.3 0.3 1.2 0.5 0.5 0.0 -0.1 0.2 -0.1 -0.0 -0.7 -0.0 0.3 -0.1 -0.5 0.5 -0.1 -0.4 -0.5 0.2 0.7 0.6 0.0 0.3 0.2 0.3 0.1
Diabetes diagnosed by doctor 3.2 5.3 15.3 2.5 1.7 1.9 2.3 2.2 2.2 2.4 2.4 2.5 1.1 2.4 1.2 -1.3 2.2 2.3 3.9 2.3 2.6 2.2 3.2 3.6 2.7 2.7 1.2 2.1 0.2 2.4 2.2 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 3.7 -0.0 -0.1 -0.5 -0.2 -1.9 -0.2 -0.5 -0.1 -0.1 -0.0 -0.1 -0.1 0.4 0.0 -0.0 1.1 0.2 1.0 -0.2 1.0 0.4 -0.1 -0.3 -1.0 -0.6 -0.8 -0.5 -0.4 -0.3
Friendships satisfaction 0.3 0.3 2.2 -0.1 0.0 -0.2 -0.1 -0.8 -0.6 -0.4 -0.3 -0.4 0.9 -0.2 0.1 -0.6 0.2 -0.1 -1.5 0.2 0.2 0.1 -1.0 -0.2 -0.9 -1.3 0.2 0.5 -0.0 0.5 0.0 1.0
Qualifications: nursing, teaching 1.1 1.6 6.3 1.4 1.3 0.5 1.0 2.1 1.9 2.5 1.4 1.2 0.9 1.4 1.0 -1.0 1.2 1.9 0.3 0.9 0.2 1.5 0.7 0.9 1.2 0.6 0.6 2.1 0.6 0.4 1.4 1.4
Commuting to job workplace: Walk 0.2 0.2 1.3 -0.3 -0.0 -0.8 -0.7 -1.1 -0.4 -0.3 -0.3 -0.2 -0.5 -0.3 -0.2 0.5 -0.0 -0.4 0.4 -0.2 0.1 -0.4 -0.1 0.1 -0.2 0.0 0.1 -0.6 0.6 0.6 -0.4 -0.5
Eye problems/disorders: Cataract 1.0 1.1 2.4 -1.1 -1.0 -0.9 -1.3 -1.2 -1.2 -0.7 -1.0 -0.6 -1.5 -1.1 -1.0 1.3 -1.2 -1.1 0.7 -1.2 1.0 -1.5 0.0 -0.7 -0.6 -0.1 -1.0 -1.3 -0.8 -1.0 -1.1 -1.6
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 3.6 -1.8 -1.5 -1.9 -1.5 -0.8 -1.5 -1.4 -1.8 -1.7 -1.5 -1.8 -1.3 1.5 -1.7 -1.7 -0.2 -1.6 -0.3 -1.8 -0.7 -1.3 -1.6 -1.1 -1.2 -1.5 -1.0 -1.0 -1.7 -1.5
Medication for cholesterol 0.2 0.3 0.7 0.5 0.8 -0.4 0.2 0.3 0.7 0.7 0.4 0.4 0.7 0.5 0.4 -0.6 0.3 0.8 -0.8 0.7 -0.6 0.7 0.2 0.3 -0.0 -0.4 0.2 0.6 -0.0 -0.1 0.1 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.6 0.1 -0.2 0.1 0.6 1.0 0.7 -0.6 0.2 0.4 -0.2 0.1 0.4 0.2 -0.1 0.1 1.1 0.1 1.3 -0.1 0.5 0.5 0.6 1.0 0.3 0.4 0.2 0.2 0.4 -0.0
Back pain experienced in last month 0.5 0.7 2.5 0.5 0.8 0.8 0.8 1.1 0.8 0.4 0.5 0.2 0.9 0.4 0.6 -1.2 0.6 0.6 -0.6 1.1 -0.8 0.6 0.6 0.3 0.1 -0.3 -0.9 1.6 -1.4 -1.6 0.7 1.4
Mineral and other dietary supplements 1.2 1.6 5.4 -1.0 -1.1 -1.2 -1.0 -2.3 -1.6 -1.5 -1.0 -1.2 -1.5 -1.0 -1.3 1.9 -1.4 -1.5 0.2 -1.1 -0.3 -1.5 -0.2 -0.7 -1.0 -0.9 -1.4 -1.0 -1.0 -1.3 -1.4 -1.3
Breast cancer (self-reported) 1.9 2.3 7.7 1.3 1.4 2.8 2.1 1.5 1.6 2.2 1.3 1.5 1.7 1.3 1.8 -1.9 1.5 1.7 -0.7 1.6 1.0 1.3 0.3 1.0 1.1 0.7 1.4 1.8 0.7 1.2 1.6 1.8
Asthma (self-reported) 0.2 0.4 2.9 -0.1 0.2 -0.2 0.3 1.7 0.3 0.3 -0.1 -0.2 0.2 -0.2 -0.2 -0.6 -0.1 0.1 -0.8 0.3 0.0 0.1 0.3 -0.0 -0.3 -0.4 -0.5 1.3 -1.6 -1.2 0.3 0.8
Osteoporosis (self-reported) 1.9 2.3 4.6 1.8 1.5 1.4 1.8 2.2 1.7 1.6 1.9 1.8 1.3 1.8 1.3 -1.4 1.9 1.8 1.4 1.5 0.4 2.0 1.5 1.5 1.8 1.5 0.6 1.1 0.7 0.9 1.6 1.1
Osteoarthritis (self-reported) 0.5 0.6 1.8 0.5 -0.3 1.2 0.9 1.4 0.2 1.2 0.6 0.8 1.0 0.6 1.1 -1.1 0.5 0.7 -0.1 0.3 0.5 0.5 -0.3 -0.2 0.6 0.5 1.0 0.4 1.1 1.0 0.8 0.7
Medication: Aspirin 0.2 0.3 1.9 -0.2 -0.8 -0.1 -0.3 -1.3 -0.8 -0.3 -0.2 -0.2 -0.5 -0.2 -0.5 0.5 -0.3 -0.4 0.8 -0.2 0.0 -0.4 0.1 -0.0 -0.2 -0.4 -0.7 -1.4 0.1 0.0 -0.7 -0.9
Medication: Gliclazide 0.4 0.5 4.7 0.2 -0.2 0.1 0.4 2.2 0.6 0.7 0.2 0.3 -0.8 0.1 -1.1 0.6 -0.1 0.4 0.9 0.2 0.6 0.1 0.4 0.7 0.1 -0.1 -1.5 -0.2 -0.8 -1.0 -0.2 -0.6
Illnesses of father: None of the above (group 1) 0.3 0.4 2.7 -0.1 -0.7 0.2 0.2 -0.8 -0.7 -0.2 -0.3 0.3 -0.3 -0.2 -0.5 0.3 -0.5 -0.0 -0.2 0.4 -1.0 -0.1 0.2 0.1 -0.5 -0.7 -1.6 -0.8 -0.9 -1.5 -0.9 -0.5
Smoking status: Current 1.1 1.7 3.5 -1.4 -1.8 -1.5 -1.4 -1.7 -1.4 -1.9 -1.3 -1.2 -1.3 -1.3 -1.1 1.5 -1.7 -1.3 0.2 -1.5 -0.1 -1.6 -0.4 -1.3 -1.1 -0.8 -0.8 -1.6 -0.4 -0.8 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 3.0 0.3 0.4 -0.1 0.0 -1.0 -0.1 -0.5 0.2 0.3 0.5 0.3 0.0 0.3 0.5 0.1 0.2 0.3 0.2 0.5 -0.3 0.4 0.1 -0.1 0.7 -0.8 1.7 1.5 -0.1 -0.0
Whole body water mass 0.5 2.6 8.1 -1.2 -1.2 -1.4 -1.1 -2.0 -1.7 -1.8 -1.5 -1.2 -1.1 -1.2 -1.5 1.4 -1.8 -1.5 -0.7 -0.2 -2.9 -1.2 -0.1 -0.2 -2.0 -2.6 -2.2 -1.6 -2.0 -1.8 -2.4 -1.1
Leg predicted mass (right) 0.9 4.7 11.7 -1.9 -1.6 -1.9 -1.9 -2.9 -2.6 -2.3 -2.3 -1.8 -1.4 -2.0 -2.1 1.8 -2.2 -2.1 -1.3 -0.9 -3.1 -2.0 -0.8 -1.0 -2.9 -3.4 -2.7 -2.4 -2.0 -2.0 -3.1 -1.6
Arm fat mass (left) 0.1 0.5 1.8 -0.0 -0.0 0.9 -0.1 -1.2 -1.1 0.3 -0.3 0.3 -0.3 -0.1 -0.5 0.2 0.0 0.2 0.6 0.9 -0.7 0.1 1.2 1.0 -0.7 -1.2 -1.3 -0.6 -0.7 -0.3 -1.0 -0.2
Number of self-reported non-cancer illnesses 1.2 2.1 6.8 1.4 1.3 0.9 1.3 2.6 1.7 1.6 1.5 1.0 1.6 1.4 0.7 -1.5 1.5 1.8 1.6 1.6 1.3 1.9 1.9 1.4 1.6 1.1 0.3 1.5 -0.8 0.1 1.7 1.5
Average weekly champagne plus white wine intake 0.3 0.4 1.5 0.8 0.7 -0.1 0.7 1.2 0.8 0.2 0.6 0.5 0.9 0.8 0.6 -0.6 0.7 0.3 0.0 1.0 -0.6 0.9 0.5 0.7 0.3 0.0 0.4 -0.1 -0.1 0.7 0.2 0.6
Miserableness 0.2 0.3 2.1 0.4 0.3 1.1 0.3 -1.4 0.1 0.1 0.2 0.4 0.3 0.4 0.1 -0.2 0.5 0.5 0.4 0.9 0.4 0.7 0.9 1.0 -0.1 -0.4 -0.2 0.1 0.5 0.5 -0.1 0.4
Guilty feelings 0.2 0.3 1.1 -0.2 0.7 -0.5 0.2 1.1 0.5 -0.4 -0.4 -0.2 0.4 -0.3 0.0 0.0 0.0 -0.4 -0.7 -0.1 -0.6 0.2 -0.5 -0.1 -0.6 -0.7 0.9 0.7 0.4 1.0 0.0 0.8
Wears glasses or contact lenses 1.3 1.5 4.3 -1.4 -1.3 -1.5 -1.4 -0.3 -1.3 -1.0 -1.2 -1.4 -0.3 -1.4 -0.5 0.5 -0.9 -1.2 -2.1 -1.5 -2.0 -1.1 -2.0 -1.8 -1.3 -1.4 -0.9 -0.7 -0.4 -1.3 -0.7 -0.5
Ever taken oral contraceptive pill 0.3 0.3 1.3 -0.0 0.1 0.7 0.4 0.5 -0.2 0.7 -0.1 0.3 0.7 -0.0 -0.3 -0.5 0.3 0.2 -0.9 0.4 -1.1 0.4 -0.6 -0.2 -0.5 -1.0 -0.6 -0.6 0.6 -0.4 -0.5 0.2
Hearing aid user 0.1 0.1 0.4 -0.1 0.2 -0.2 0.1 0.1 0.2 0.0 -0.0 -0.2 0.1 0.0 -0.2 -0.1 -0.3 0.1 0.0 0.1 -0.7 0.3 0.5 -0.1 0.0 -0.1 -0.0 0.3 -0.4 -0.4 0.0 0.2
Mother’s age at death 0.7 0.9 4.5 0.0 -1.1 -0.2 0.0 0.8 -0.1 -0.8 0.1 -0.1 -1.3 -0.0 -0.7 1.6 -0.9 -0.1 2.1 -0.2 1.9 -0.5 1.3 0.7 0.3 0.2 -1.3 -0.0 -2.1 -1.1 -0.1 -0.9
Financial situation satisfaction 0.7 0.9 3.4 1.2 0.8 1.1 0.9 -1.1 0.5 0.5 1.0 1.0 1.3 1.1 0.7 -0.9 1.0 1.0 0.2 1.9 -0.4 1.2 1.3 1.5 0.5 -0.4 -0.4 0.9 -0.6 0.0 0.6 1.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 1.4 -0.1 0.1 -0.2 -0.2 -1.2 -0.1 0.2 -0.1 -0.0 0.5 -0.1 0.2 -0.3 -0.1 0.2 0.0 0.3 -0.8 -0.1 0.4 -0.1 -0.1 -0.2 -0.2 -0.2 -0.2 -0.4 -0.2 0.2
Commuting to job workplace: Public transport 0.2 0.2 1.1 0.3 0.4 -0.1 0.2 -0.6 0.4 1.0 0.2 0.1 0.8 0.3 0.3 -1.0 0.6 0.3 -0.8 0.4 -0.1 0.3 -0.2 0.2 0.0 0.1 0.5 0.4 0.3 0.7 0.3 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 5.1 -0.1 -0.1 -0.3 -0.2 0.2 0.1 -0.2 -0.1 0.1 -1.6 -0.1 -0.4 1.2 -0.3 -0.1 2.3 -0.2 1.2 -0.6 1.1 1.0 0.5 1.0 0.0 -0.2 0.1 0.5 -0.1 -1.1
Medication: Blood pressure 0.3 0.5 1.3 -0.9 -0.5 -0.6 -0.5 -0.0 -0.6 -1.1 -0.9 -0.8 -0.4 -0.9 -0.5 0.6 -0.6 -1.1 -0.8 -0.8 -0.6 -0.9 -1.0 -1.0 -0.9 -0.9 -0.1 -0.1 0.1 -0.1 -0.5 -0.2
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.9 1.3 0.6 1.9 1.8 0.7 1.4 1.5 1.4 1.5 1.4 1.4 1.7 -1.5 1.2 1.4 0.7 1.1 2.2 0.9 0.9 1.0 1.4 1.4 1.6 1.6 0.8 1.6 1.6 1.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.7 0.3 1.2 0.6 0.1 1.3 1.1 1.2 0.3 0.4 1.0 0.3 0.4 -1.3 0.9 0.8 -0.6 0.6 0.1 1.0 0.0 0.3 0.2 -0.0 0.6 0.6 -0.2 0.5 0.7 0.9
High cholesterol (Self-reported) 0.3 0.6 7.7 0.2 0.1 -0.4 0.3 1.6 0.1 -0.3 0.2 0.0 -0.4 0.1 -0.3 0.5 -0.1 0.0 1.7 0.4 2.8 0.5 0.9 1.1 0.4 0.4 -0.0 0.3 -0.5 0.2 0.3 -0.1
Medication: Bendroflumethiazide 0.8 1.2 4.7 -1.5 -0.9 -1.7 -0.8 -0.2 -1.1 -2.2 -1.4 -1.2 -0.4 -1.5 -0.3 0.7 -1.1 -1.4 -1.1 -0.9 -0.6 -1.3 -0.9 -1.2 -1.4 -1.3 -0.5 -0.2 -1.0 -0.8 -0.8 -0.2
Medication: Paracetamol 0.1 0.2 0.6 -0.5 -0.2 -0.4 -0.3 -0.4 -0.5 -0.2 -0.5 -0.0 0.0 -0.5 -0.2 -0.1 -0.4 -0.4 -0.7 -0.3 -0.7 -0.7 -0.2 -0.7 -0.4 -0.4 -0.3 -0.3 0.1 -0.8 -0.4 -0.2
Medication: Lisinopril 1.4 1.8 5.6 -1.3 -1.3 -2.1 -1.6 -1.4 -1.7 -2.4 -1.3 -1.4 -1.2 -1.3 -1.6 1.6 -1.3 -1.5 -0.1 -1.1 -1.0 -1.2 -0.8 -0.8 -1.3 -1.3 -1.3 -1.4 -0.5 -0.8 -1.5 -1.3
Medication: Atorvastatin 1.1 1.4 6.5 1.1 1.0 1.2 1.1 0.6 0.8 0.9 0.9 1.1 0.2 1.1 0.3 -0.5 0.9 1.2 2.5 1.4 2.5 1.4 2.5 1.7 1.0 0.8 -0.2 0.1 -0.3 0.4 0.3 0.2
Illnesses of father: High blood pressure 0.0 0.1 0.3 -0.1 0.1 -0.2 -0.3 0.2 0.1 -0.1 0.1 -0.0 -0.4 -0.0 0.1 0.3 0.0 -0.3 0.1 -0.4 0.1 -0.6 -0.3 -0.3 0.2 0.3 0.0 0.3 0.1 -0.3 0.3 -0.2
Alcohol drinker status: Never 0.3 0.3 1.3 -0.6 -0.5 0.0 -0.1 -0.5 -0.5 -0.7 -0.5 -0.5 -0.1 -0.6 -0.3 0.0 -0.4 -0.7 -1.0 -0.8 0.6 -0.9 -1.1 -1.0 -0.4 -0.1 0.2 -0.5 0.2 -0.1 -0.2 -0.3
Ever smoked 1.2 2.1 6.2 1.6 0.5 1.9 1.4 0.8 1.1 1.1 1.6 1.8 0.5 1.5 1.1 -0.5 1.2 1.6 2.5 1.6 2.2 1.4 2.0 2.0 1.7 1.6 0.8 1.0 0.9 1.3 1.4 0.6
Basal metabolic rate 0.4 2.1 7.5 -1.0 -0.9 -1.0 -1.0 -1.9 -1.6 -1.5 -1.4 -0.9 -0.8 -1.1 -1.3 1.1 -1.4 -1.2 -0.6 0.1 -2.7 -1.0 0.1 0.0 -1.9 -2.5 -2.1 -1.4 -1.8 -1.5 -2.2 -0.8
Leg fat percentage (left) 0.2 0.7 3.4 0.5 0.1 1.7 0.3 -0.9 -0.4 0.7 0.4 0.8 -0.5 0.5 -0.0 0.2 0.6 0.7 1.9 1.0 1.0 0.4 1.8 1.6 0.5 0.3 -0.6 0.2 -0.2 0.4 0.1 -0.2
Arm fat-free mass (left) 0.4 2.1 5.2 -1.0 -1.0 -1.1 -1.1 -2.0 -1.5 -1.6 -1.3 -1.1 -1.2 -1.1 -1.5 1.5 -1.6 -1.2 -0.2 -0.0 -2.3 -1.1 0.3 0.2 -1.7 -2.2 -2.2 -1.4 -2.1 -1.7 -2.1 -1.1
Number of operations (self-reported) 0.5 0.7 7.7 0.4 -0.6 -0.1 1.0 2.8 0.6 0.6 0.6 0.1 1.1 0.4 0.7 -1.2 0.3 0.2 -0.8 -0.1 -0.6 0.1 -1.0 -0.5 0.6 0.5 0.1 1.1 -0.5 -0.5 1.2 1.0
Average weekly beer plus cider intake 2.1 3.1 7.6 1.6 2.1 2.8 1.9 1.0 1.5 2.4 1.7 2.3 1.1 1.7 1.8 -1.4 1.9 2.1 1.7 1.7 2.1 1.7 1.6 1.5 1.9 1.8 1.5 0.6 2.1 1.6 1.4 0.7
Irritability 0.3 0.6 3.5 -0.1 -0.1 0.2 0.1 -0.3 -0.1 -0.5 -0.2 -0.0 1.9 -0.2 0.8 -1.6 0.7 0.1 -1.4 0.4 -0.9 0.3 -0.5 -0.3 -0.5 -0.9 -0.0 1.1 -0.1 -0.0 0.5 1.8
Risk taking 0.7 1.0 5.7 -0.3 -1.0 -0.5 -0.4 0.6 -0.7 -0.4 -0.5 -0.2 -1.7 -0.4 -0.8 2.0 -0.9 -0.4 1.5 -0.0 2.4 -0.4 1.0 1.0 -0.6 -0.7 -1.4 -0.2 -1.6 -0.5 -0.7 -1.0
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.5 0.7 -0.1 -0.3 0.6 1.1 0.8 -0.5 0.9 0.6 1.5 0.7 1.5 -0.9 0.5 0.4 -0.4 0.6 -1.4 0.6 0.3 -0.2 0.9 0.7 0.2 1.6 -1.0 -0.9 1.4 1.5
Fractured/broken bones in last 5 years 2.6 3.3 7.1 2.0 2.0 1.5 1.9 1.5 2.0 1.3 1.8 2.2 1.2 2.0 1.7 -0.9 1.9 1.4 2.1 2.0 1.5 2.0 2.0 2.5 1.8 1.6 1.9 1.6 1.8 2.7 1.7 1.5
Age started oral contraceptive pill 4.3 5.4 10.8 -2.7 -2.3 -2.6 -3.0 -1.8 -2.5 -1.7 -2.6 -2.5 -2.0 -2.7 -2.3 2.0 -2.3 -2.3 -2.7 -3.0 -2.4 -2.5 -3.3 -2.7 -2.5 -2.0 -0.9 -2.1 0.3 -1.0 -2.1 -2.1
Diastolic blood pressure, automated reading 0.7 2.2 6.3 1.5 1.3 0.6 1.4 1.2 0.9 1.0 1.4 1.3 2.2 1.5 1.5 -1.8 1.8 1.5 -1.3 1.5 -1.3 1.9 -0.2 1.0 0.9 0.2 1.5 2.5 1.1 1.5 1.9 2.5
Ever depressed for a whole week 0.6 0.7 2.3 0.9 0.5 1.3 0.9 0.1 0.8 -0.1 1.0 0.9 0.1 0.9 0.8 -0.2 0.7 0.6 1.3 0.6 0.9 0.4 0.8 1.1 1.2 1.5 0.6 0.8 0.1 0.7 1.0 0.3
Unable to work because of sickness or disability 0.1 0.1 1.9 -0.3 -0.4 -0.3 -0.4 -0.5 -0.3 -0.2 -0.3 -0.6 -0.2 -0.4 -0.1 -0.1 -0.3 -0.2 0.1 -0.4 1.4 -0.2 0.2 -0.2 -0.3 -0.2 0.3 0.1 -0.2 0.3 -0.0 -0.1
Commuting to job workplace: Cycle 0.3 0.4 1.5 -0.4 -0.7 -0.5 -0.9 -1.0 -0.9 -0.1 -0.3 -0.5 -0.4 -0.4 -0.6 0.2 -0.3 -0.0 -0.4 -0.7 0.4 -0.7 -0.8 -1.0 -0.2 -0.2 -0.7 -1.2 0.5 -0.9 -0.5 -1.0
Myopia 0.1 0.1 1.3 0.1 -0.3 0.0 0.2 1.1 0.1 0.8 0.0 -0.1 -0.1 0.0 -0.2 -0.1 -0.1 0.1 -0.1 -0.1 0.8 0.2 -0.4 -0.1 -0.1 -0.3 0.2 -0.3 0.0 0.4 -0.1 -0.3
Vascular/heart problems diagnosed by doctor 1.0 2.8 5.2 -2.1 -2.3 -1.7 -1.9 -0.8 -1.4 -1.2 -2.1 -1.8 -2.0 -2.0 -1.9 1.6 -2.2 -1.6 -1.4 -2.3 -0.4 -2.1 -1.7 -1.8 -2.0 -1.4 -1.0 -1.2 -0.5 -1.0 -1.7 -1.6
Cholesterol lowering medication 0.2 0.3 1.8 0.0 -0.5 0.6 0.0 -0.7 -0.2 -0.8 0.0 0.3 -0.5 0.0 -0.2 0.9 -0.1 -0.1 1.0 0.2 1.4 0.0 0.4 0.6 0.1 -0.0 -0.1 -0.1 1.1 0.6 -0.1 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 3.1 -0.8 -1.2 -0.7 -0.8 -1.3 -1.0 -0.9 -0.7 -1.0 -0.6 -0.8 -0.7 0.4 -0.8 -0.9 -0.1 -0.9 -1.7 -1.0 -0.3 -1.1 -0.4 -0.1 -0.4 -1.8 -0.0 -0.6 -0.9 -1.3
Pain experienced in last month 0.2 0.3 2.6 0.3 0.3 0.0 -0.2 0.1 0.2 0.2 0.3 0.3 0.1 0.3 0.1 0.4 0.2 0.2 -0.2 -0.3 0.4 0.4 -0.9 -0.2 0.3 0.3 1.3 -0.4 1.6 1.6 0.2 -0.2
Supplements: Calcium 1.8 2.0 7.3 1.3 1.1 0.9 1.3 2.7 1.9 1.5 1.5 1.3 1.6 1.3 1.5 -1.6 1.7 1.8 0.2 1.0 1.3 1.6 0.4 0.6 1.5 1.3 0.7 1.8 0.5 0.4 2.1 1.6
Basal cell carcinoma (self-reported) 0.4 0.4 1.8 0.6 0.4 0.3 0.6 0.6 0.4 0.7 0.6 0.6 0.2 0.6 0.2 -0.3 0.7 0.5 1.1 0.3 0.9 0.5 0.5 0.6 1.0 1.4 0.8 -0.3 1.1 1.1 0.6 -0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.0 0.9 0.5 1.0 0.8 -1.0 0.7 0.1 0.8 0.7 1.0 0.9 0.8 -1.2 0.7 0.4 0.8 0.9 0.0 0.7 0.9 0.9 0.8 0.9 1.3 0.3 1.0 1.4 0.6 0.8
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.5 -0.1 -0.0 0.3 -0.2 -0.6 0.0 0.2 -0.2 0.1 -0.0 -0.1 -0.2 -0.0 0.0 0.2 -0.0 0.2 -0.6 0.1 0.2 0.4 -0.4 -0.5 -0.0 0.7 0.3 0.3 0.0 0.5
Heart disease (siblings) 0.2 0.2 0.8 -0.1 -0.0 0.6 -0.0 -0.4 0.3 0.2 0.2 0.0 0.2 -0.0 0.6 -0.6 0.2 -0.1 -0.5 -0.6 0.6 -0.3 -0.9 -0.8 0.5 0.8 0.4 -0.3 0.6 -0.1 0.3 -0.3
Alcohol drinker status: Previous 0.3 0.4 3.0 -0.1 -0.3 -0.2 -0.1 -0.3 -0.0 -0.4 -0.4 -0.2 0.1 -0.1 0.2 -0.0 -0.2 -0.2 -0.3 0.2 1.1 0.2 -0.2 0.4 -0.6 -0.5 1.2 0.8 1.5 1.7 -0.1 0.7
Pack years of smoking 0.3 0.4 2.5 -0.5 -0.7 -0.6 -1.1 -1.6 -0.8 -0.6 -0.6 -1.0 -0.7 -0.5 -0.9 0.5 -0.7 -0.5 0.9 -0.4 0.5 -0.4 0.5 -0.1 -0.4 -0.1 -0.4 -0.4 -0.5 -0.1 -0.6 -0.6
Impedance of whole body 2.2 11.2 20.0 2.8 3.9 3.5 3.0 3.5 3.6 3.8 2.9 3.0 4.4 2.8 3.6 -4.5 4.1 3.5 -1.1 2.6 0.9 3.5 0.4 1.4 2.5 2.2 4.5 4.0 3.6 4.0 4.0 4.4
Leg fat mass (left) 0.1 0.6 2.6 0.0 -0.2 0.9 -0.2 -1.5 -0.9 0.2 -0.2 0.3 -0.7 -0.0 -0.5 0.5 -0.0 0.2 1.5 0.8 0.0 -0.0 1.6 1.4 -0.3 -0.5 -1.2 -0.4 -1.0 -0.2 -0.7 -0.4
Arm predicted mass (left) 0.3 1.3 4.4 -0.7 -0.6 -0.7 -0.6 -1.3 -1.0 -1.2 -1.0 -0.7 -0.8 -0.7 -1.1 1.0 -1.2 -0.9 -0.1 0.4 -2.1 -0.6 0.6 0.5 -1.4 -1.9 -1.8 -0.9 -2.1 -1.4 -1.7 -0.6