Hub : Genes

NAPEPLD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0210	3.8e-03	0.000	0.010	0.000	0.013	0.000	2.8e-01	1.7e-02	3.3e-01	9.7e-03	3.1e-01
2	GTEx	Artery Tibial	0.1560	0.0578	1.5e-04	0.029	NA	0.036	NA	0.034	2.3e-03	NA	8.3e-04	NA	9.8e-04
3	GTEx	Cells Transformed fibroblasts	0.3130	0.0830	5.6e-05	0.094	NA	0.047	NA	0.063	1.5e-07	NA	1.8e-04	NA	1.8e-05
4	GTEx	Nerve Tibial	0.1557	0.0619	2.6e-03	-0.002	NA	0.001	NA	0.001	4.7e-01	NA	2.9e-01	NA	2.8e-01
5	GTEx	Thyroid	0.2670	0.0580	4.1e-09	0.156	NA	0.196	NA	0.179	5.5e-12	NA	5.7e-15	NA	1.1e-13
6	METSIM	Adipose	0.0480	0.0187	6.2e-05	0.017	0.026	0.008	0.025	0.019	1.2e-03	7.1e-05	1.9e-02	8.9e-05	6.5e-04
7	NTR	Blood	0.0134	0.0073	6.6e-03	0.001	0.002	0.002	0.002	0.000	1.2e-01	4.5e-02	7.9e-02	4.9e-02	2.5e-01
8	YFS	Blood	0.0325	0.0106	1.6e-08	0.036	0.022	0.031	0.025	0.032	5.1e-12	7.8e-08	1.7e-10	7.7e-09	1.2e-10
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0589	0.0275	1.4e-05	0.033	0.038	0.037	NA	0.037	1.2e-04	3.8e-05	4.6e-05	NA	4.4e-05
10	TCGA	Thyroid Carcinoma	0.0460	0.0240	5.3e-03	-0.001	0.033	0.032	NA	0.011	4.1e-01	3.4e-04	3.7e-04	NA	2.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.2	1.9	4.7	-0.1	-1.9	-2.2	-1.7	-1.8	-0.0	-0.3	-1.8	-1.1	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	3.0	-0.1	-0.6	0.0	-0.2	-1.0	0.6	-1.7	0.1	0.5	-1.0
Depressed Affect (Nagel 2018)	0.1	0.3	1.1	1.0	-0.8	0.4	0.8	0.1	-0.3	-0.1	0.2	0.6	0.2
Depression (Nagel 2018)	1.1	1.6	2.9	0.6	0.6	1.4	1.2	1.7	1.2	-1.5	1.5	0.9	1.6
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.0	-0.7	0.2	0.0	0.6	-0.7	-0.3	0.6	0.0	0.3	-1.0
Neuroticism (Nagel 2018)	0.4	1.0	4.6	0.8	-0.7	0.8	2.1	-0.3	0.1	-1.1	0.8	1.3	-0.2
Schizophrenia (2018)	0.7	1.5	3.9	-0.0	0.7	1.8	1.1	0.2	0.8	-2.0	1.5	1.5	-0.8
Schizophrenia vs Biploar Disorder	3.8	5.0	10.2	1.9	2.7	3.2	2.1	0.3	2.6	0.2	3.0	2.8	1.0
Worry (Nagel 2018)	0.4	0.8	2.5	0.7	-1.2	0.3	1.6	-0.1	-1.0	-1.3	0.2	0.5	-0.5
Alzheimer’s Disease (in mother)	2.8	3.3	6.0	0.1	1.8	1.7	1.3	2.3	1.9	2.1	2.3	0.9	2.5
Alzheimer’s Disease (in father)	0.7	0.7	4.2	0.1	-0.9	-0.8	-2.0	-0.1	0.5	-0.5	-0.7	-0.5	0.5
Alzheimer’s Disease (including proxy)	1.3	1.9	4.9	0.6	1.1	1.1	0.3	1.9	1.9	1.1	1.6	0.5	2.2
Crohns Disease (2017)	0.7	1.4	5.8	0.6	-1.1	-0.6	-0.1	-2.4	0.0	-0.5	-0.5	0.9	-2.3
Irritable Bowel Disease (IBD)	1.4	3.4	11.8	-0.6	-1.9	-1.5	-0.3	-2.7	-0.4	-2.5	-1.4	-0.1	-3.4
Ulcerative Colitis (UC)	1.7	3.2	9.0	-1.2	-1.8	-1.7	-0.3	-2.0	-0.4	-3.0	-1.3	-0.8	-3.0
Major Depression (MDD)	0.5	0.6	2.5	0.6	0.0	0.5	0.7	-0.4	0.9	-1.6	0.2	0.8	-0.5
Reaction Time	1.1	2.1	10.0	1.3	1.4	0.5	1.4	2.0	-0.1	0.4	0.6	-0.9	3.2
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.9	-0.7	1.3	0.5	1.4	0.1	0.3	0.1	1.0	0.6	0.1
Breast Cancer	0.6	1.4	6.2	-0.4	0.2	1.0	1.5	1.0	-1.4	2.5	1.0	0.8	0.1
Ovarian Cancer	0.6	0.8	2.0	-0.4	-0.7	-1.3	-1.4	-0.9	-0.1	0.6	-1.4	-0.8	-0.3
Prostate Cancer	0.3	0.4	1.5	-1.2	-0.5	0.2	0.7	0.8	-0.2	-0.9	0.3	-0.3	-0.3
Age at First Birth	1.0	1.5	9.9	-0.2	0.5	0.4	-1.0	1.3	-0.6	3.1	0.3	0.0	1.1
Bipolar Disorder (2011)	0.5	0.5	1.5	-0.5	-0.4	-1.1	0.4	-0.6	-0.3	-0.8	-1.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	1.3	0.4	0.0	0.2	-0.1	1.1	-0.5	0.6	0.2	-0.5	0.3
Coronary Artery Disease (CAD)	0.7	0.8	3.1	-1.7	0.1	0.3	0.3	1.8	0.8	-0.0	0.2	0.4	0.9
Crohns Disease (2012)	0.7	1.1	3.8	0.1	-0.5	0.2	-0.4	-1.9	-0.0	-1.1	-0.2	1.1	-1.9
Mean Putamen Volume	3.1	3.5	8.6	-0.5	-2.6	-1.8	-1.1	-2.6	-0.1	-2.1	-1.9	-0.4	-2.9
Fasting Glucose	1.5	1.8	6.3	0.7	1.6	0.3	1.4	2.1	-0.8	2.5	0.8	0.1	0.9
HbA1C	0.8	0.9	4.2	-1.3	0.7	-0.4	0.7	0.5	0.8	-2.1	0.3	-0.8	-0.3
HDL Cholesterol	0.4	0.7	1.7	1.0	-0.9	-0.8	-0.2	-1.3	-0.4	-0.4	-0.8	-0.2	-1.3
LDL Cholesterol	0.3	0.5	3.1	-1.8	-0.3	-0.1	-0.9	-0.2	0.4	-0.5	-0.3	-0.1	-0.5
Lupus	0.2	0.3	0.8	0.9	-0.3	0.0	-0.3	-0.8	0.4	-0.2	-0.2	0.1	-0.9
Neuroticism (2016)	0.8	1.1	5.3	0.6	-0.7	-0.2	1.9	-0.9	0.0	-2.3	0.3	0.1	-0.5
Primary Biliary Cirrhosis	0.8	1.1	3.2	-1.2	-0.9	-0.9	-0.9	-1.8	-0.5	-0.7	-1.0	0.1	-1.4
Rheumatoid Arthritis	1.9	2.7	7.2	-1.4	2.7	1.5	0.9	2.4	1.4	0.6	1.3	0.1	2.2
Schizophrenia (2014)	0.6	1.3	4.9	-0.1	0.6	1.2	1.5	0.1	1.1	-2.2	0.8	1.2	-0.7
Triglycerides	0.2	0.4	0.7	-0.9	-0.2	-0.6	-0.4	0.5	-0.8	0.4	-0.8	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	1.8	2.0	9.2	0.2	1.4	1.0	1.4	3.0	0.1	2.3	1.0	0.0	0.0
Ulcerative Colitis	3.1	4.4	15.0	-1.0	-2.7	-1.0	-0.7	-2.6	-0.5	-3.3	-1.3	0.2	-3.9
Blood Eosinophil Count	0.2	1.2	4.6	0.5	1.5	0.4	-0.4	0.4	-0.6	2.1	-0.4	0.3	2.0
Blood Platelet Count	0.1	0.9	2.8	0.9	-0.1	1.7	0.6	-0.6	0.5	0.6	1.4	1.6	-0.4
Blood Red Count	0.2	2.0	8.7	-2.0	0.4	0.5	-0.4	3.0	0.2	0.0	0.8	-0.9	2.2
Blood White Count	0.3	2.3	6.9	-0.8	-0.2	0.9	0.6	2.6	-0.6	2.6	0.7	-0.7	2.4
Heel T-Score	0.1	0.5	1.9	0.2	-1.4	-0.7	-0.3	-0.5	-0.7	0.5	-0.8	-0.6	-0.9
BMI	0.5	2.9	13.2	0.0	0.9	1.2	0.1	3.6	1.0	1.0	1.2	-0.7	3.0
Height	0.2	4.2	10.9	-2.4	1.8	-0.7	2.0	3.3	-2.2	1.5	-0.7	-2.0	2.4
Waist Hip Ratio (WHR)	0.4	1.7	3.6	-0.2	1.9	1.2	1.7	-0.6	1.5	0.9	1.5	1.8	0.2
Systolic Blood Pressure	0.2	0.9	2.9	-1.7	-0.1	0.7	1.5	1.2	-0.5	-1.3	0.7	0.2	-0.3
Smoking Status	0.3	0.6	3.5	1.9	-0.7	-0.2	-0.4	-0.2	-0.9	1.0	-0.0	-0.5	-0.2
Allergy or Eczema	1.2	3.3	7.0	-0.9	2.2	1.9	2.6	2.3	-0.1	1.1	1.8	0.2	2.5
Cardiovascular Disease	0.2	0.8	3.0	-0.8	0.3	0.9	0.9	1.7	-0.8	-0.8	0.8	-0.0	1.0
Hypothyroidism (self reported)	2.1	4.9	13.5	-1.0	-2.7	-3.5	-1.3	-1.6	-1.8	-1.2	-3.7	-2.0	-1.6
Respiratory disease	0.4	0.9	3.1	-0.0	1.3	0.9	0.9	1.0	0.5	0.7	0.9	0.1	1.8
Type 2 Diabetes (T2D) (2018)	4.8	8.9	32.6	-0.0	3.5	2.7	2.2	5.7	1.0	1.6	2.6	-0.1	4.7
Lung FEV1/FVC ratio	0.7	3.7	8.3	-2.9	1.3	2.5	2.3	2.1	0.7	-0.0	2.6	1.6	1.2
Lung FVC	0.4	1.9	7.2	2.7	-0.7	-1.1	0.1	-2.2	0.4	0.1	-0.9	0.6	-1.9
Neuroticism	0.6	1.3	3.6	1.8	-1.0	0.4	1.9	-1.0	0.4	-1.6	0.1	1.1	-0.7
Chronotype (morning person)	6.9	16.0	44.0	1.0	-4.2	-3.3	-2.7	-6.6	0.1	-5.8	-3.5	0.3	-5.8
Hair Pigment	0.2	4.3	14.1	3.6	-1.6	-1.0	-1.1	-3.8	1.0	-0.3	-1.1	0.7	-2.9
Tanning	0.0	0.6	1.5	1.2	-0.7	-0.1	-0.4	-0.9	-0.7	-0.8	-0.3	0.1	-1.2
Hand grip strength (left)	1.1	2.9	6.6	-0.6	-2.4	-1.4	-1.8	-0.6	-2.5	2.6	-1.4	-1.0	-1.0
Number of treatments/medications taken	0.3	0.6	3.1	-0.9	-1.2	0.3	0.4	0.0	0.0	-1.8	-0.1	0.2	-0.2
Average weekly spirits intake	0.5	0.7	1.4	0.4	-0.3	-0.8	-1.1	0.7	-0.6	1.2	-0.5	-1.1	1.0
Sensitivity / hurt feelings	1.5	2.5	12.0	0.4	0.2	1.2	3.5	-0.3	1.3	-2.4	1.3	1.4	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.6	2.9	1.3	-0.8	0.0	-0.2	-0.3	0.9	-1.7	-0.2	0.1	0.4
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.5	0.3	-0.2	1.3	1.2	-0.3	-0.9	-0.3	-1.2	1.2
Relative age of first facial hair	0.4	0.8	2.8	1.0	1.7	0.7	0.7	0.1	1.3	-0.5	0.8	0.4	0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	8.0	-0.9	-0.6	-0.5	1.2	-1.2	-0.3	-2.8	-0.4	0.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	1.6	-1.4	-1.2	-1.0	-0.7	-0.6	-0.3	-1.2	-0.6	-1.3
Ever had hysterectomy (womb removed)	0.9	1.1	4.1	-0.1	-0.2	-0.0	0.1	1.9	-0.4	1.5	0.0	-0.8	2.0
Systolic blood pressure, automated reading	0.3	1.0	2.9	-0.8	-1.6	-0.7	-0.1	0.7	-1.7	-0.7	-0.8	-0.9	-0.7
Eye problems/disorders: Diabetes related eye disease	1.8	1.9	4.2	2.1	1.8	1.7	0.6	1.2	0.9	1.3	1.8	0.8	1.1
Angina	0.2	0.3	1.4	0.3	-0.7	0.5	-0.7	0.2	-0.5	-1.2	0.3	0.0	-0.3
Medication for hormone replacement therapy	1.7	1.9	4.6	1.6	-1.6	-1.2	-1.3	-1.8	-0.7	-0.3	-1.5	-0.4	-2.1
Vitamin and mineral supplements	0.1	0.1	0.5	-0.7	-0.2	0.2	0.1	0.4	0.1	-0.0	0.3	-0.1	-0.5
Supplements: Zinc	1.5	1.6	5.0	0.8	0.9	0.8	-0.3	-1.6	2.2	-1.2	0.7	1.7	-1.1
Medication: Co-codamol	0.9	1.1	2.2	-0.2	-1.5	-1.3	-0.9	0.0	-1.4	-0.2	-1.4	-1.4	-0.3
Medication: Metformin	2.3	3.2	11.4	0.6	1.7	1.1	1.4	3.4	1.6	0.3	1.3	-0.9	3.0
Diabetes (father)	1.4	1.7	5.8	-0.9	1.7	0.8	1.4	2.4	-0.5	0.8	0.7	-0.3	1.8
Diabetes (mother)	4.5	5.7	13.7	0.3	2.5	2.5	1.0	3.5	0.2	3.1	2.6	1.0	3.7
Severe depression (siblings)	0.8	0.9	4.0	2.0	0.5	0.1	-1.3	-0.8	0.5	1.5	-0.3	0.2	-0.3
Pack years adult smoking proportion	0.7	1.0	2.2	1.1	-1.4	-1.3	-1.5	-0.5	-0.3	-0.4	-1.1	-0.9	-0.7
Impedance of leg (right)	0.3	1.4	3.5	0.3	1.9	0.7	1.8	-1.2	1.0	-1.8	0.8	0.4	-0.4
Leg fat-free mass (left)	0.6	3.4	13.2	-0.9	1.2	0.2	-0.1	3.6	0.0	2.8	0.3	-1.0	3.1
Trunk fat percentage	1.0	4.2	9.0	-0.2	2.8	1.7	1.7	2.7	2.8	-0.7	1.7	0.1	3.0
Hand grip strength (right)	1.8	4.8	10.1	0.4	-3.2	-2.2	-1.8	-2.5	-2.6	2.1	-2.2	-0.9	-2.6
Townsend deprivation index at recruitment	0.5	0.6	2.3	-1.2	-0.7	-0.3	-1.5	-0.0	1.1	-0.8	-0.3	-0.0	-0.4
Current tobacco smoking	1.1	1.8	4.0	2.0	-1.6	-1.3	-0.8	-0.9	-1.5	1.4	-1.5	-1.1	-0.8
Average weekly fortified wine intake	0.7	0.8	2.0	-1.4	-0.6	-1.3	-0.2	-0.5	-0.1	-1.0	-1.2	-1.1	-0.7
Maternal smoking around birth	0.8	1.2	5.5	-0.0	0.2	-0.1	-2.3	0.7	-0.4	2.4	-0.2	-0.5	0.2
Fed-up feelings	0.3	0.6	4.3	2.1	-1.0	0.1	0.4	0.4	-0.1	0.2	-0.2	-0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.6	0.4	0.8	0.2	1.2	0.5	-0.6	0.8	0.1	1.0
Relative age voice broke	0.7	1.1	3.2	-0.7	-0.6	-1.1	-0.0	0.7	-0.7	-1.8	-1.1	-1.8	0.2
Taking other prescription medications	0.6	1.0	6.8	-1.2	-0.7	-0.0	0.2	-0.2	0.9	-2.6	-0.3	0.3	0.0
Age when periods started (menarche)	0.5	1.3	2.9	-1.3	1.2	1.4	1.1	-0.4	-0.7	1.2	1.0	1.7	-0.5
Bilateral oophorectomy (both ovaries removed)	3.3	3.9	10.4	-0.2	-2.2	-3.2	-1.2	-1.5	-1.7	-0.7	-3.1	-1.9	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.8	-0.2	-0.2	-0.3	-0.1	0.4	0.1	1.3	-0.2	0.1	-0.0
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	7.5	-0.2	-2.5	-1.2	-0.1	-1.0	-1.2	-2.7	-1.3	-1.3	-1.6
Qualifications: CSEs or equivalent	0.5	0.6	3.1	1.5	-0.0	-0.3	-1.8	0.0	0.4	0.2	-0.4	-0.7	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.1	-1.1	-0.9	-1.2	0.4	0.2	-0.7	-0.7	-1.1	0.5
High blood pressure	0.7	1.9	5.6	-1.8	1.1	1.4	1.5	2.4	-0.9	-0.6	1.4	0.1	1.4
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.8	-1.2	1.8	1.6	2.6	1.2	0.2	0.5	1.6	0.7	1.4
Multivitamins +/- minerals	0.1	0.1	0.4	0.3	-0.1	-0.3	-0.3	0.1	-0.4	0.6	-0.5	-0.2	0.2
Stomach or abdominal pain in last month	1.3	1.6	5.9	-1.3	0.8	0.5	1.0	2.4	0.3	-1.2	0.6	-0.9	2.0
Supplements: Glucosamine	0.2	0.3	1.8	0.6	-0.1	-0.1	-0.3	-0.5	0.2	-1.3	-0.1	-0.2	0.1
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	11.2	1.2	0.1	0.9	1.8	-1.2	2.0	-3.4	0.8	0.9	-0.7
Medication: Atenolol	0.4	0.5	1.8	1.3	0.0	0.2	1.2	0.5	-0.5	-0.9	0.1	-0.6	0.5
Medication: Levothyroxine sodium	3.0	5.0	12.5	0.0	-2.4	-3.5	-3.0	-1.4	-1.2	-0.4	-3.5	-2.5	-1.0
Sitting height	0.7	4.7	24.2	-1.2	1.2	-0.3	-0.5	2.8	-2.4	4.9	-0.2	-1.1	2.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	-1.0	-0.0	-0.4	0.9	0.6	-1.3	-0.5	-0.2	-0.9	0.6
High blood pressure (mother)	1.2	1.8	4.3	-1.6	0.3	-1.1	0.0	1.7	-2.1	0.0	-0.9	-1.9	1.5
Body mass index (BMI)	0.7	3.1	12.3	0.1	1.2	1.2	0.5	3.5	1.4	1.1	1.3	-0.6	3.3
Impedance of leg (left)	0.3	1.4	3.5	0.3	1.8	0.9	1.9	-1.4	0.9	-1.5	0.8	0.8	-0.6
Leg predicted mass (left)	0.6	3.4	13.1	-0.9	1.2	0.2	-0.2	3.6	-0.0	2.8	0.2	-1.1	3.1
Trunk fat mass	1.0	4.2	11.0	-0.2	2.6	1.7	1.6	3.1	2.4	0.3	1.7	-0.1	3.3
Waist circumference	0.7	2.7	9.1	-0.4	1.7	0.9	1.1	2.8	1.7	1.0	1.0	-0.5	3.0
Number of incorrect matches in round	1.3	2.2	4.3	-1.5	1.6	1.6	0.8	2.1	1.2	-1.3	1.5	0.5	2.0
Past tobacco smoking	0.9	1.6	4.2	1.1	-1.0	-1.3	-0.3	-2.0	-0.4	-1.5	-1.6	-0.2	-1.8
Alcohol usually taken with meals	1.1	1.8	6.1	0.5	0.7	0.5	1.1	-1.5	1.9	-2.5	0.5	1.4	-1.4
Nervous feelings	1.0	1.9	6.2	0.9	-2.2	-1.2	0.0	0.1	-2.5	-0.7	-1.3	-1.7	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.1	-0.2	0.4	0.1	0.0	-0.1	-0.0	0.4	0.4	0.0
Hearing difficulty/problems with background noise	0.4	0.7	2.0	0.0	0.4	0.5	0.9	0.7	1.0	-1.0	0.6	-0.5	1.4
Hair/balding pattern: Pattern 2	1.6	2.1	5.1	1.0	-1.0	-1.4	-0.7	-2.3	0.3	-1.9	-1.6	-0.5	-2.1
Had menopause	0.2	0.3	0.6	-0.8	0.3	-0.1	-0.8	-0.3	0.2	-0.8	-0.2	0.4	-0.7
Had other major operations	0.6	0.7	1.8	-0.7	-0.5	-1.3	-1.0	0.2	-0.5	-0.2	-1.3	-1.4	-0.0
Forced vital capacity (FVC)	0.2	0.9	2.4	1.5	0.1	-1.0	0.1	-0.9	-1.0	1.6	-0.9	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.5	-0.2	-1.1	-1.3	-1.6	-0.6	-0.5	1.5	-1.3	-0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.7	1.9	2.1	2.4	1.4	1.7	-0.0	2.0	2.3	1.1	1.8
Qualifications: None of the above	0.8	1.8	5.0	0.1	-2.2	-1.4	-1.2	0.6	-1.6	-0.8	-1.6	-1.7	-0.3
Financial difficulties in last 2 years	1.5	2.0	4.7	0.9	1.6	1.5	0.8	2.0	1.5	0.4	1.3	0.7	2.2
Mouth/teeth dental problems	0.2	0.3	1.1	-0.6	-0.9	-0.4	-0.1	0.2	-1.1	0.0	-0.4	-0.4	0.3
Heart attack	0.4	0.6	2.4	0.2	-0.9	-0.3	-0.8	0.6	-1.6	-0.2	-0.4	-1.0	0.4
Allergy	1.1	2.5	6.7	0.3	-1.8	-2.1	-2.6	-0.6	-1.4	0.3	-2.0	-1.6	-1.2
Pain all over the body in last month	0.8	0.8	2.2	0.1	0.7	1.5	1.1	1.3	0.3	-0.1	1.4	0.6	0.4
Diabetes (self-reported)	4.8	7.4	25.6	0.6	3.4	2.2	2.0	5.1	1.4	1.2	2.2	-0.3	4.3
Hayfever/allergic rhinitis (self-reported)	3.7	4.9	12.7	-1.7	2.6	2.0	2.4	3.6	-0.0	1.7	2.1	0.1	3.1
Medication: Ramipril	1.8	2.3	6.8	-2.6	-0.6	-0.7	0.4	2.5	-1.6	0.2	-0.5	-1.6	1.9
Medication: Simvastatin	0.2	0.3	0.9	0.9	-0.7	0.6	0.6	0.2	-0.2	-0.5	0.7	0.1	0.3
Fluid intelligence score	0.4	0.8	4.1	-0.5	1.1	0.7	2.0	0.3	0.5	-0.2	1.2	0.6	0.5
Illnesses of siblings	0.3	0.4	1.2	1.0	0.9	0.0	1.1	-0.3	-0.4	0.7	0.2	0.3	0.3
Neuroticism score	0.6	1.3	3.4	1.8	-1.5	-0.4	1.3	-1.2	-0.3	-1.6	-0.5	0.1	-0.8
Weight	0.9	4.3	15.9	-0.4	1.9	1.0	0.7	4.0	1.1	2.2	1.0	-0.8	3.8
Impedance of arm (right)	0.7	3.2	18.9	0.3	1.0	-0.5	1.5	-2.4	1.4	-4.4	-0.6	0.3	-1.4
Arm fat percentage (right)	1.0	4.1	10.8	0.0	2.2	1.7	1.7	3.2	2.5	-0.8	1.7	-0.1	3.3
Trunk fat-free mass	0.8	4.7	18.2	-1.1	1.0	0.5	0.1	3.8	-0.9	4.3	0.6	-0.9	3.2
Hip circumference	0.8	3.4	14.0	-0.2	1.7	0.7	1.2	3.7	1.1	0.4	0.7	-1.3	3.4
Time employed in main current job	1.6	1.8	5.8	1.1	0.7	0.8	-0.4	-2.4	0.8	-0.1	0.5	1.8	-2.3
Alcohol intake versus 10 years previously	1.2	1.8	5.4	-0.0	2.1	1.4	0.5	2.3	0.4	0.1	1.4	0.3	1.8
Father’s age at death	0.6	0.9	2.0	-1.4	0.4	1.2	0.3	0.7	0.8	0.4	1.4	1.3	0.1
Worrier / anxious feelings	0.3	0.5	1.6	-0.4	-1.3	-0.8	0.4	-0.5	-0.4	-0.9	-0.8	-0.0	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	4.7	2.2	-0.3	0.9	0.9	1.0	0.3	0.6	0.6	0.3	0.9
Falls in the last year	0.4	0.5	1.7	-0.3	0.3	0.1	1.1	1.3	-0.4	-1.0	-0.1	-0.7	0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.5	-1.2	0.1	-0.3	-0.5	0.8	-1.1	0.3	-0.5	-0.6	0.4
Number of live births	0.3	0.4	2.5	-0.5	-1.6	-0.3	-0.1	-0.6	-0.2	-0.3	-0.3	0.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.3	0.4	-0.3	0.9	-0.4	-0.3	0.5	-0.3	0.3	-0.6
Pulse rate	1.0	1.7	8.3	2.9	0.3	0.3	-0.1	-0.8	1.6	1.9	0.4	1.0	-0.6
Happiness	0.6	0.7	2.2	1.2	-1.1	-0.7	-1.5	0.1	-0.5	0.2	-0.8	-0.8	-0.3
Noisy workplace	0.7	0.9	1.9	0.9	-1.1	-1.1	-0.6	-1.0	-0.5	1.3	-1.4	-0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	0.8	-0.2	-0.7	0.4	0.3	0.1	0.4	-0.7	-1.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	6.3	-1.6	0.9	1.4	0.8	2.5	0.3	1.5	1.5	0.3	1.6
Mouth/teeth dental problems: Dentures	0.7	1.1	4.1	-1.3	0.4	0.1	0.5	2.0	-0.4	1.0	0.4	-0.8	1.8
Asthma	0.5	1.0	1.9	-0.6	0.9	1.3	0.8	0.3	1.4	-1.0	1.2	1.1	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.2	-0.2	-0.5	-0.6	-0.2	0.3	0.3	-0.6	-0.7	0.3
Medication: Cholesterol lowering	0.4	0.6	1.4	0.8	0.2	0.1	0.8	1.1	-0.7	-0.4	0.0	-1.0	1.2
Depression (self-reported)	0.8	1.0	3.1	0.7	-1.1	-0.2	0.3	-1.8	0.2	-0.5	-0.4	1.1	-1.8
Medication: Lansoprazole	0.7	0.8	2.3	0.0	1.1	0.8	-0.1	1.5	0.5	-0.4	1.0	-0.2	1.5
Prospective memory result	1.7	2.1	4.5	0.4	1.8	2.1	1.8	1.2	0.9	-0.2	1.7	1.6	1.5
Lung cancer (father)	1.1	1.3	2.6	-0.6	-1.3	-1.1	-1.4	-1.6	-0.8	-0.3	-1.2	0.2	-1.6
Illnesses of mother	1.0	1.2	4.2	2.0	0.7	0.6	-0.3	-1.1	1.7	0.7	0.4	1.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.2	-0.2	-0.8	0.8	-0.2	-0.8	0.6	-0.7	-0.4	-0.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.6	0.3	-0.1	-0.9	0.5	-0.6	1.0	-0.4	-0.3	0.5
Impedance of arm (left)	0.7	3.0	16.6	0.6	0.7	-0.7	1.0	-2.7	1.4	-4.1	-0.7	0.2	-1.5
Arm fat mass (right)	0.9	3.9	13.0	-0.2	1.9	1.4	1.3	3.6	1.8	0.7	1.4	-0.4	3.5
Trunk predicted mass	0.8	4.7	18.1	-1.2	1.0	0.4	0.1	3.8	-0.9	4.3	0.5	-0.9	3.2
Standing height	0.2	1.7	7.0	-0.9	1.7	-0.4	0.3	1.6	-0.5	2.6	-0.3	-0.8	1.5
Length of working week for main job	2.0	2.2	6.5	0.1	-1.8	-1.5	-1.2	-2.1	-1.2	-0.4	-1.6	-0.2	-2.6
Exposure to tobacco smoke at home	0.4	0.4	1.5	-0.2	0.7	0.1	-1.2	0.7	1.2	0.1	0.1	-0.2	0.7
Breastfed as a baby	0.1	0.2	0.9	-0.6	1.0	-0.1	0.3	-0.4	0.4	-0.1	0.0	0.2	-0.1
Tense / ‘highly strung’	0.6	1.0	3.8	1.1	-0.8	0.0	1.8	-0.9	-0.4	-1.9	-0.0	0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	11.0	1.9	-1.6	0.1	0.1	-3.3	0.3	-0.9	-0.2	1.8	-2.7
Hair/balding pattern: Pattern 4	0.7	1.8	5.4	2.3	-1.8	-1.0	-0.7	-2.1	-0.2	-0.4	-0.5	-0.0	-1.5
Birth weight of first child	1.1	2.1	4.4	2.1	-0.5	-1.8	-1.2	-1.7	0.1	-1.4	-1.9	-1.2	-0.9
Peak expiratory flow (PEF)	0.2	0.5	2.5	-1.6	0.3	-0.4	1.2	0.5	-0.5	-0.0	-0.4	-0.4	0.3
Pulse wave reflection index	0.3	0.4	1.3	-1.2	1.0	0.7	-0.1	0.2	-0.2	-0.5	0.6	0.4	0.7
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	1.4	0.8	1.0	0.5	1.1	0.2	1.4	1.0	0.1	1.4
Loud music exposure frequency	0.5	0.6	1.3	0.7	-0.7	-1.1	0.3	-0.6	-0.5	-0.4	-1.1	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.9	0.1	-0.6	-1.6	0.3	0.1	-1.7	1.4	-1.4	-1.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	0.8	0.1	-0.2	-0.1	-1.4	-0.2	-1.2	-0.3	-0.0	-1.8
Blood clot in the leg (DVT)	0.6	0.7	2.6	0.8	0.7	0.7	1.2	0.0	1.6	-0.3	1.0	0.7	0.1
Medication: Paracetamol	0.2	0.4	1.3	-0.2	0.4	0.6	0.0	1.1	0.5	-0.2	0.4	-0.5	1.1
Headache pain in last month	0.2	0.3	0.6	-0.3	0.7	0.6	0.7	0.1	0.4	0.6	0.7	0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.3	0.1	-0.6	-0.4	-1.7	-2.1	1.3	0.7	-0.3	1.4	-1.7
Glaucoma (self-reported)	3.7	4.3	8.0	-0.2	2.7	2.8	2.1	0.8	1.9	1.6	2.7	2.8	1.4
Gout (self-reported)	1.2	1.6	3.9	1.4	0.8	1.0	0.8	-1.3	2.0	-1.0	1.1	1.8	-0.7
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	9.8	-0.4	-2.5	-3.0	-1.3	-1.8	-1.1	-1.4	-3.1	-1.7	-1.6
Medication: Amlodipine	0.5	0.7	3.9	-0.2	0.0	0.0	1.6	-0.0	-0.6	-2.0	0.1	-0.4	-0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	0.1	-0.8	-0.9	-1.1	-0.6	-0.5	0.6	-1.0	-0.6	0.1
Birth weight	0.7	1.5	3.9	0.7	1.4	1.1	1.2	-0.5	2.0	-1.4	1.1	1.4	0.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.2	-0.5	0.1	0.3	-0.3	-0.8	0.6	0.1	0.6	-0.7
High blood pressure (siblings)	0.4	0.5	2.4	0.2	-1.3	-0.5	-1.6	0.1	0.3	-0.3	-0.5	-0.6	0.0
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	1.1	-0.3	-1.2	0.4	-0.5	-1.4	0.7	-1.0	-0.7	-0.7
Body fat percentage	1.0	4.0	9.5	0.2	2.5	1.8	1.5	2.9	2.6	-0.5	1.8	-0.1	3.1
Leg fat percentage (right)	0.9	3.3	9.6	0.5	2.0	1.6	1.0	3.1	1.7	0.6	1.7	-0.4	3.1
Arm fat-free mass (right)	0.9	4.4	17.2	-1.1	0.8	0.2	-0.3	3.7	-0.8	4.2	0.3	-1.1	2.9
Exposure to tobacco smoke outside home	0.3	0.4	1.4	0.4	0.8	0.5	0.1	0.4	1.2	-0.7	0.7	0.2	0.2
Comparative body size at age 10	2.2	6.2	14.7	1.3	-3.8	-3.3	-0.8	-1.2	-2.6	-1.7	-3.6	-2.8	-1.5
Number of full brothers	0.7	0.9	2.9	1.2	-0.5	1.2	-0.8	-0.5	0.2	1.1	0.7	1.7	-0.2
Worry too long after embarrassment	0.6	1.0	2.9	1.7	-0.7	-0.9	0.2	-1.1	-0.0	-1.7	-0.8	-0.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.8	0.7	-0.7	-0.2	2.2	-1.2	-0.2	-0.8	-0.2	0.6	-1.0
Wheeze or whistling in the chest in last year	0.7	1.2	2.8	1.6	0.6	1.4	0.3	0.3	1.7	0.5	1.2	1.0	1.4
Number of children fathered	0.8	0.9	2.4	-0.1	0.6	1.0	1.5	-0.8	0.9	-0.2	1.1	1.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	0.1	0.2	0.3	0.1	0.0	0.7	-0.5	0.4	0.4	-0.0
Age at first live birth	0.6	1.1	4.2	-0.7	2.0	0.8	0.8	0.2	1.1	1.0	0.9	0.6	1.3
Pulse wave peak to peak time	0.4	0.4	1.3	0.7	-0.3	0.1	1.2	-0.6	0.6	-0.8	0.4	0.4	-0.7
Health satisfaction	0.7	1.0	3.3	-0.0	-1.8	-0.9	-0.4	0.5	-1.2	-0.6	-1.2	-1.3	-0.2
Shortness of breath walking on level ground	0.5	0.5	2.2	-0.0	-1.5	-0.7	-0.6	0.8	-0.6	0.3	-0.7	-0.9	-0.3
Qualifications: College or University degree	0.4	1.4	6.4	-2.5	0.2	0.6	0.7	-1.3	0.5	-0.4	0.3	1.3	-1.5
Eye problems/disorders: None of the above	4.1	4.8	9.2	-0.9	-2.6	-3.0	-2.4	-1.1	-1.8	-1.9	-3.0	-2.4	-1.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.2	-0.1	2.1	1.8	1.3	-0.1	1.3	0.9	1.6	1.5	-0.4
Emphysema/chronic bronchitis	1.2	1.4	2.3	0.2	-1.5	-1.4	-0.9	-0.9	-1.5	1.1	-1.5	-0.8	-1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.2	0.7	-0.9	-0.2	-1.0	-0.2	0.1	-0.8	-0.1	-0.9
Neck or shoulder pain in last month	0.8	1.1	3.2	0.0	-0.4	1.5	0.3	-0.6	1.0	-1.1	1.4	1.8	-0.9
Medication: Blood pressure	1.1	2.0	6.5	-0.4	1.4	1.4	1.4	2.5	-0.5	-0.0	1.3	-0.6	2.3
Angina (self-reported)	0.2	0.3	1.4	0.3	-0.6	0.6	-0.6	0.1	-0.2	-1.2	0.4	0.2	-0.2
Migraine (self-reported)	0.6	0.7	1.6	-0.2	-0.8	-0.6	-0.8	0.9	-1.1	0.8	-0.7	-1.3	0.8
Medication: Ibuprofen	0.1	0.2	0.7	0.1	0.3	0.3	0.2	0.4	0.5	0.5	0.2	0.1	0.8
Medication: Allopurinol	0.9	1.2	2.8	1.0	0.8	0.8	1.7	-1.1	1.5	-0.5	0.8	1.4	-0.5
Medication: Omeprazole	0.6	0.7	2.2	0.5	-0.9	0.6	1.4	-0.3	0.4	-1.5	0.4	0.8	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	1.3	0.8	-0.4	0.1	-0.4	-1.1	0.4	-1.0	-0.3	0.3	-0.7
Mean time to correctly identify matches	0.8	1.5	7.2	1.2	0.7	0.6	0.8	1.9	-0.2	0.2	0.6	-0.7	2.7
Heart disease (mother)	1.2	1.5	3.2	-1.6	0.8	1.5	1.4	1.8	0.1	-0.3	1.6	0.7	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	4.1	-1.6	-0.7	-1.0	-0.6	0.0	-2.0	0.6	-1.1	-0.5	-0.6
Whole body fat mass	1.0	4.3	11.9	0.1	2.4	1.7	1.3	3.4	2.3	0.7	1.7	-0.2	3.5
Leg fat mass (right)	1.1	4.3	14.5	0.1	2.2	1.6	0.9	3.8	1.6	1.5	1.7	-0.5	3.5
Arm predicted mass (right)	0.9	4.6	17.8	-0.8	1.1	0.6	-0.1	3.8	-0.5	4.2	0.7	-0.8	3.2
Pulse rate, automated reading	0.5	1.6	5.7	2.4	-0.9	0.2	-1.2	-1.2	1.3	1.6	0.1	1.4	-0.7
Alcohol intake frequency.	0.3	0.7	2.2	-0.1	0.8	0.7	1.3	-0.4	0.8	0.4	0.5	1.5	0.4
Comparative height size at age 10	0.2	1.0	3.4	0.7	0.9	-0.8	0.1	1.5	0.5	0.8	-0.7	-1.1	1.9
Number of full sisters	0.4	0.5	1.1	-0.9	-0.2	-0.7	-0.9	0.1	-0.6	0.5	-0.7	-0.2	-1.0
Suffer from ‘nerves’	0.9	1.5	6.4	0.6	0.2	1.5	2.5	-0.1	-0.1	-1.5	1.5	1.2	0.4
Overall health rating	0.1	0.2	0.7	0.1	-0.3	0.9	0.5	0.7	0.0	0.3	0.7	0.5	0.2
Chest pain or discomfort	0.4	0.6	2.0	-1.0	0.3	0.8	0.6	0.6	0.8	-1.4	0.7	0.4	0.6
Had major operations	0.2	0.2	0.8	-0.2	0.0	-0.2	-0.8	0.2	0.7	0.9	0.0	0.1	0.2
Age at last live birth	0.5	0.8	2.2	-1.1	1.5	0.1	0.8	0.9	0.1	0.7	0.4	-0.4	1.5
Family relationship satisfaction	0.4	0.5	1.9	0.9	-0.8	-0.5	-1.4	0.3	0.1	-0.7	-0.7	-0.6	0.2
Leg pain on walking	0.5	0.6	1.8	1.3	-1.0	-0.2	-0.7	0.2	-0.7	1.3	-0.2	-0.4	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	3.9	1.7	1.0	1.4	-0.6	0.9	0.7	2.0	1.2	0.8	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.0	1.6	0.9	1.5	1.7	0.8	0.6	-0.6	1.3	0.8	0.4
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	9.2	1.0	-1.3	-1.8	-0.6	-3.0	-1.3	-0.3	-1.9	-0.7	-2.8
Medication: Aspirin	0.7	0.9	2.7	-0.8	0.2	1.2	0.6	1.7	0.2	-0.1	1.4	0.3	1.4
Supplements: Vitamin C	0.3	0.3	1.1	0.9	0.2	0.2	-0.2	-0.1	0.8	-0.6	0.3	0.0	1.1
Knee pain experienced in last month	0.5	0.8	2.1	0.5	0.2	-0.3	1.3	0.8	0.3	-1.5	-0.2	-1.2	1.2
Hypertension (Self-reported)	0.8	2.3	6.9	-1.8	1.1	1.6	1.6	2.6	-0.6	-0.2	1.6	0.3	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.4	2.1	-0.2	0.4	0.4	1.2	-0.2	-0.9	0.5	-0.9	1.3
Illnesses of father: Heart disease	0.2	0.3	1.3	0.4	0.1	-0.5	-0.9	-0.3	-0.5	1.1	-0.2	0.1	-0.7
Illnesses of siblings: Diabetes	1.5	1.8	5.0	0.3	1.3	1.4	1.5	2.2	0.8	-0.1	1.8	0.8	1.7
Smoking status: Previous	1.1	1.6	3.6	-1.3	1.4	1.6	0.4	1.5	0.9	0.7	1.9	0.9	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.5	0.7	0.5	-0.0	0.7	0.3	0.7	0.4	-0.0	0.7
Whole body fat-free mass	0.8	4.6	15.3	-1.1	1.2	0.4	-0.0	3.9	-0.6	3.9	0.5	-1.0	3.3
Leg fat-free mass (right)	0.5	2.9	10.9	-0.9	0.9	0.1	-0.4	3.3	-0.2	2.9	0.1	-0.8	2.7
Arm fat percentage (left)	1.0	3.8	10.1	0.2	2.0	1.6	1.6	2.9	2.7	-0.8	1.7	-0.1	3.2
Average weekly red wine intake	0.3	0.4	1.7	-0.1	0.5	0.4	1.3	0.7	-0.5	-0.9	0.5	-0.0	0.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.1	-0.4	-1.1	-1.0	0.5	-0.1	-1.2	-1.5	-1.3	-0.9	-0.9
Mood swings	0.3	0.5	1.1	1.0	-0.5	0.9	1.1	0.2	0.4	-0.9	0.7	0.4	0.4
Loneliness, isolation	0.3	0.4	1.2	0.1	-0.2	0.7	0.9	0.7	0.1	-1.1	0.4	0.8	0.5
Long-standing illness, disability or infirmity	1.2	1.9	8.8	-0.8	0.9	0.8	1.5	0.4	1.8	-3.0	1.0	0.7	0.6
Ever had bowel cancer screening	0.2	0.3	0.8	0.6	-0.6	-0.3	-0.6	0.5	-0.4	-0.2	-0.1	-0.6	0.9
Diabetes diagnosed by doctor	4.0	6.6	28.6	-0.1	2.6	1.9	1.8	5.3	1.1	0.8	1.9	-0.7	4.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	1.5	0.6	0.9	0.9	0.5	0.8	-0.0	0.9	0.3	1.1
Friendships satisfaction	0.6	0.7	5.6	0.5	-0.7	-0.2	0.7	-0.4	0.1	-2.4	-0.2	-0.5	-0.3
Qualifications: nursing, teaching	1.0	1.6	7.8	-0.0	1.7	0.8	1.0	-0.8	2.8	-0.6	0.8	1.0	0.9
Commuting to job workplace: Walk	0.4	0.4	1.2	-1.0	0.1	-0.7	-0.6	0.1	0.3	-1.1	-0.4	-1.1	0.1
Eye problems/disorders: Cataract	3.2	3.7	8.7	0.6	1.9	2.9	1.2	1.3	1.9	1.3	2.8	2.3	1.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.6	0.0	1.3	1.2	0.6	0.7	0.8	0.9	1.1	1.1	0.7
Medication for cholesterol	0.1	0.2	0.5	-0.1	0.7	0.0	-0.1	0.3	0.6	0.5	0.1	-0.1	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	1.7	-0.7	0.7	1.6	-1.0	-0.4	-0.8	0.7	0.8	-0.7
Back pain experienced in last month	0.2	0.3	1.3	0.8	0.6	0.3	-0.0	1.1	-0.0	0.1	0.4	-0.0	0.8
Mineral and other dietary supplements	0.3	0.3	1.3	0.1	0.4	0.4	0.4	-0.2	0.7	1.1	0.7	0.8	-0.3
Breast cancer (self-reported)	1.6	1.9	4.7	-1.0	-1.2	-1.7	-1.2	-1.5	0.0	-2.2	-1.8	-1.1	-1.1
Asthma (self-reported)	0.3	0.7	1.4	-0.7	0.9	0.9	0.6	0.5	1.0	-0.6	0.9	0.7	1.2
Osteoporosis (self-reported)	0.3	0.3	0.9	0.4	0.7	0.9	0.7	-0.1	-0.3	0.2	0.9	0.5	0.2
Osteoarthritis (self-reported)	0.9	1.2	3.1	-0.1	-1.1	-1.1	-1.8	-0.7	0.4	-1.7	-1.1	-1.1	-0.3
Medication: Aspirin	0.9	1.1	3.2	-0.9	0.4	1.3	0.6	1.8	0.3	0.5	1.4	0.5	1.6
Medication: Gliclazide	3.5	4.0	11.8	0.2	2.2	1.7	1.4	3.4	1.6	1.6	1.7	0.1	3.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	0.5	-0.5	-0.8	-0.2	-0.6	0.5	0.7	-0.8	-0.7	0.4
Smoking status: Current	1.0	1.6	3.4	1.8	-1.5	-1.2	-0.6	-0.7	-1.6	1.2	-1.4	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.6	-0.2	-1.0	-0.6	-0.7	-1.0	-1.2	0.6	-0.6	0.1	-1.6
Whole body water mass	0.7	4.2	14.6	-1.1	1.0	0.3	-0.1	3.8	-0.6	3.8	0.4	-1.0	3.1
Leg predicted mass (right)	0.5	2.9	10.8	-0.9	0.8	0.1	-0.4	3.3	-0.2	2.9	0.0	-0.9	2.7
Arm fat mass (left)	0.9	3.8	12.4	-0.2	1.9	1.3	1.1	3.5	2.0	0.7	1.4	-0.4	3.5
Number of self-reported non-cancer illnesses	0.6	1.0	3.6	-0.1	0.2	1.0	1.5	1.0	-0.1	-1.9	0.8	-0.3	1.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	-0.1	-0.4	-0.5	0.5	-0.6	0.7	-0.3	-0.2	-0.1
Miserableness	0.2	0.3	1.7	1.3	-0.5	0.7	0.2	0.1	-0.4	0.1	0.3	0.2	0.7
Guilty feelings	0.3	0.5	3.3	0.2	0.9	0.3	1.8	0.2	0.4	0.1	0.1	0.7	0.4
Wears glasses or contact lenses	0.8	0.9	2.7	-0.4	0.4	0.3	0.9	-1.0	1.6	-1.3	0.8	1.1	-0.5
Ever taken oral contraceptive pill	0.7	0.8	4.1	-0.8	1.1	0.5	0.1	-0.1	2.0	-0.0	0.7	0.7	0.8
Hearing aid user	1.8	2.1	3.8	-1.2	-1.6	-1.4	-1.7	0.6	-1.6	-1.6	-1.6	-1.9	-0.0
Mother’s age at death	1.3	1.6	3.4	-0.1	-1.5	-1.0	-1.3	0.9	-1.9	1.5	-1.0	-1.8	0.4
Financial situation satisfaction	1.1	1.4	3.8	1.9	-0.9	-1.1	-1.0	0.9	-1.1	0.8	-1.1	-1.7	0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.6	-0.1	0.6	0.5	0.9	1.3	0.3	0.5	0.4	0.2	0.6
Commuting to job workplace: Public transport	0.7	0.8	2.7	-1.2	0.2	-0.4	0.5	-1.1	1.3	-1.6	-0.4	0.5	-0.5
Eye problems/disorders: Glaucoma	5.3	6.3	12.1	0.0	3.4	3.5	2.7	1.1	1.1	2.5	3.3	3.2	1.5
Medication: Blood pressure	0.5	1.0	4.5	-1.3	0.1	0.1	0.1	2.1	-1.0	0.1	0.1	-0.8	1.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	0.1	-0.6	-0.7	-1.0	-0.6	-0.0	-0.4	-0.7	-0.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	4.8	-1.8	-0.1	-0.8	-0.1	0.3	-0.5	-2.2	-1.0	-1.0	-0.1
High cholesterol (Self-reported)	1.0	1.7	4.7	-1.1	-2.2	-0.9	-0.9	0.5	-1.8	-1.8	-1.0	-1.4	-0.4
Medication: Bendroflumethiazide	0.6	0.9	2.4	-0.1	-1.0	-1.0	-1.4	0.0	-1.5	0.4	-1.0	-1.3	-0.1
Medication: Paracetamol	0.1	0.1	0.4	0.0	0.0	0.0	-0.6	-0.1	0.7	0.2	-0.1	0.0	0.2
Medication: Lisinopril	0.9	1.2	3.8	-0.1	0.4	1.9	1.2	1.1	-0.1	0.5	1.9	0.9	-0.1
Medication: Atorvastatin	1.0	1.3	4.2	-0.5	-0.4	-0.5	0.3	1.6	-0.9	-1.4	-0.5	-2.1	1.5
Illnesses of father: High blood pressure	1.6	2.0	4.5	0.0	1.7	2.1	1.5	1.6	0.6	-0.0	2.0	1.4	1.0
Alcohol drinker status: Never	0.5	0.6	2.3	-0.2	-0.6	-0.2	-0.1	-1.5	-0.0	0.2	-0.0	1.2	-1.4
Ever smoked	0.3	0.5	1.8	-0.1	-0.2	0.7	0.3	1.4	-0.1	0.9	0.9	-0.2	1.2
Basal metabolic rate	0.8	4.7	16.6	-0.9	1.4	0.6	0.1	4.1	-0.1	3.6	0.7	-0.9	3.5
Leg fat percentage (left)	0.8	2.9	8.0	0.5	1.8	1.7	1.0	2.8	1.7	0.7	1.7	-0.1	2.7
Arm fat-free mass (left)	0.9	4.6	16.2	-1.0	1.3	0.6	0.0	4.0	-0.4	3.9	0.7	-0.9	3.2
Number of operations (self-reported)	0.7	1.1	2.7	-0.1	-1.6	-1.6	-0.8	-1.1	-0.2	-0.3	-1.5	-1.0	-0.8
Average weekly beer plus cider intake	0.7	1.1	3.6	-0.0	1.9	1.1	-0.9	0.2	1.5	0.7	1.0	1.2	-0.2
Irritability	0.7	1.2	2.8	0.7	-1.6	-1.7	-0.5	-1.0	-0.9	-0.5	-1.5	-1.4	-0.6
Risk taking	1.5	2.2	6.8	0.7	0.9	2.1	0.7	-0.8	2.2	0.4	1.9	2.6	-0.5
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	0.6	-0.8	-0.1	-0.7	-0.8	-0.7	1.6	-0.2	0.3	-1.1
Fractured/broken bones in last 5 years	0.7	0.9	3.3	0.4	0.2	-0.3	-1.8	-1.3	0.9	0.9	0.3	1.3	-1.0
Age started oral contraceptive pill	0.2	0.3	1.6	-0.4	-0.2	-0.1	-1.3	-0.4	1.0	0.0	-0.2	0.3	-0.1
Diastolic blood pressure, automated reading	0.2	0.7	3.5	1.1	-1.0	-0.3	0.1	-0.7	-0.3	-1.9	-0.5	-0.3	-0.8
Ever depressed for a whole week	0.6	0.8	4.9	2.2	0.3	0.6	0.6	-0.8	-0.3	0.3	0.5	0.3	-0.9
Unable to work because of sickness or disability	0.3	0.4	2.2	0.5	-0.7	0.1	-0.4	-0.5	-0.4	-1.5	0.1	0.1	-0.8
Commuting to job workplace: Cycle	0.8	1.0	7.0	0.4	-0.9	0.0	-0.5	-0.5	0.3	-2.7	0.0	-1.1	-0.2
Myopia	0.6	0.8	5.2	-0.5	-0.7	-0.6	-0.2	-0.1	0.6	-2.3	-0.6	-0.6	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.2	1.2	-1.0	-1.1	-1.4	-2.0	1.0	0.6	-1.1	0.1	-1.4
Cholesterol lowering medication	0.2	0.4	0.8	0.8	-0.9	0.5	-0.6	-0.5	-0.2	-0.8	0.5	0.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.8	0.1	-0.7	0.8	1.9	0.2	0.0	-0.8	0.7	0.9	-0.5
Pain experienced in last month	0.5	0.9	3.6	-1.9	-0.5	-1.3	-0.6	0.2	-0.7	-0.4	-1.0	-1.3	-0.1
Supplements: Calcium	1.2	1.3	4.8	1.6	-0.9	-0.9	-0.9	-2.2	0.0	-0.2	-1.2	-0.2	-1.4
Basal cell carcinoma (self-reported)	0.3	0.4	2.1	-0.3	-0.5	-0.1	-0.3	-1.0	0.2	-0.2	-0.1	0.5	-1.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	0.3	-0.9	-0.4	-0.7	0.3	-1.4	-0.6	-0.4	-0.8	0.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	4.5	0.8	1.0	1.0	1.6	0.4	2.1	-0.3	1.3	0.9	0.5
Heart disease (siblings)	1.1	1.3	3.5	0.6	0.3	1.5	0.0	-1.0	1.9	-1.4	1.1	1.6	-0.5
Alcohol drinker status: Previous	1.7	1.9	4.1	-0.3	-2.0	-1.7	-0.4	-1.1	-1.4	-1.7	-1.8	-1.5	-0.6
Pack years of smoking	1.1	1.7	3.5	1.1	-1.8	-1.6	-1.9	-0.9	-0.4	-0.7	-1.4	-1.0	-1.1
Impedance of whole body	0.5	2.4	11.4	0.2	1.2	-0.3	1.2	-2.4	1.2	-3.4	-0.3	0.4	-1.5
Leg fat mass (left)	1.0	3.8	13.0	0.0	2.0	1.5	0.9	3.6	1.6	1.5	1.6	-0.3	3.3
Arm predicted mass (left)	0.9	4.8	17.4	-1.0	1.4	0.7	0.0	4.2	-0.4	3.8	0.7	-0.9	3.4