Hub : Genes

LRRC17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1880	0.0830	6.5e-03	0.004	NA	0.009	NA	0.011	1.8e-01	NA	1.0e-01	NA	8.2e-02
2	GTEx	Breast Mammary Tissue (Male)	0.0489	0.0405	1.1e-01	0.010	NA	-0.007	NA	-0.002	1.8e-01	NA	5.1e-01	NA	3.5e-01
3	GTEx	Breast Mammary Tissue (Female)	0.2478	0.1336	1.5e-02	0.118	NA	0.082	NA	0.106	2.2e-04	NA	1.9e-03	NA	4.5e-04
4	TCGA	Breast Invasive Carcinoma	0.0717	0.0373	3.6e-08	0.041	0.039	0.043	NA	0.054	5.8e-09	1.6e-08	2.6e-09	NA	2.8e-11
5	TCGA	Lung Adenocarcinoma	0.1403	0.0725	1.5e-03	0.009	0.009	0.030	NA	0.020	2.5e-02	2.5e-02	1.9e-04	NA	1.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.1	-1.1	0.2	-0.8	0.9	-0.5
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	1.5	-0.1	1.3	1.7	-0.3
Depressed Affect (Nagel 2018)	0.6	1.3	2.3	-0.2	-1.5	-1.3	0.9	-1.3
Depression (Nagel 2018)	0.2	0.3	0.8	0.4	0.3	-0.6	0.9	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.6	-0.5	0.1	-0.9	-0.5
Neuroticism (Nagel 2018)	0.7	1.6	3.5	0.4	-1.9	-0.8	1.3	-1.5
Schizophrenia (2018)	1.4	3.0	7.4	2.7	-0.2	2.3	1.4	0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	0.5	0.9	0.3	-1.2	1.5
Worry (Nagel 2018)	0.7	1.4	2.7	1.5	-1.0	0.8	1.6	-0.6
Alzheimer’s Disease (in mother)	2.4	2.8	7.4	-0.8	1.1	-1.8	-2.7	-1.3
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.3	0.3	-0.2	0.5	0.2
Alzheimer’s Disease (including proxy)	1.0	1.4	3.0	-0.3	1.3	-1.2	-1.7	-0.9
Crohns Disease (2017)	0.1	0.2	0.3	0.2	-0.5	0.4	0.5	-0.5
Irritable Bowel Disease (IBD)	1.0	2.4	5.0	1.4	-0.7	1.8	2.2	-1.3
Ulcerative Colitis (UC)	2.0	3.8	7.9	1.6	-0.4	2.1	2.8	-2.0
Major Depression (MDD)	0.6	0.7	2.2	1.5	-0.5	0.7	0.2	-0.5
Reaction Time	0.9	1.8	3.3	-1.8	1.5	-1.5	-0.8	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.0	-1.4	0.5	-0.8	-0.6	0.2
Breast Cancer	2.7	6.6	13.7	1.2	-3.7	1.2	-2.8	-3.0
Ovarian Cancer	0.9	1.2	3.7	-1.9	1.0	-1.0	0.6	0.6
Prostate Cancer	0.2	0.3	0.7	0.1	-0.8	0.1	0.9	0.2
Age at First Birth	0.5	0.8	1.7	-1.2	0.3	-0.8	-1.3	0.2
Bipolar Disorder (2011)	0.4	0.3	1.1	0.0	-0.2	-0.7	-0.2	-1.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.4	0.1	-0.1	0.1	-1.2	-0.4
Coronary Artery Disease (CAD)	2.9	3.4	14.7	-0.4	-1.3	-0.6	-0.4	-3.8
Crohns Disease (2012)	0.7	1.1	2.1	1.0	-0.4	1.3	1.4	-0.7
Mean Putamen Volume	2.6	3.0	5.4	2.0	-0.7	2.2	2.3	-0.4
Fasting Glucose	1.6	1.9	7.1	-1.0	0.9	-0.5	-2.7	-0.6
HbA1C	1.3	1.4	2.0	1.1	1.4	0.9	1.0	1.4
HDL Cholesterol	0.5	0.8	2.5	-0.8	-1.6	-0.8	-0.3	0.4
LDL Cholesterol	0.3	0.5	0.8	0.9	0.9	0.7	0.5	-0.4
Lupus	0.3	0.4	1.3	0.2	0.8	0.1	-0.1	1.2
Neuroticism (2016)	1.7	2.5	4.6	1.9	-2.1	0.9	1.8	0.4
Primary Biliary Cirrhosis	0.6	0.9	2.4	1.5	-0.4	1.2	0.1	0.6
Rheumatoid Arthritis	1.4	2.0	4.3	-1.5	1.4	-1.2	-2.1	0.3
Schizophrenia (2014)	0.6	1.3	2.6	1.6	-0.0	1.4	1.4	0.3
Triglycerides	0.3	0.6	1.6	0.7	1.3	0.6	0.4	0.4
Type 2 Diabetes (T2D) (2012)	2.9	3.3	7.8	-1.6	-0.2	-2.0	-2.8	-1.5
Ulcerative Colitis	4.3	6.2	14.2	0.0	-1.4	3.8	3.2	-2.1
Blood Eosinophil Count	0.8	5.9	12.4	-3.5	0.4	-3.5	-2.1	-0.0
Blood Platelet Count	0.0	0.5	1.0	-0.3	-1.0	0.5	-0.7	-0.8
Blood Red Count	0.0	0.1	0.1	0.3	0.1	0.1	0.4	-0.3
Blood White Count	0.1	1.0	1.7	-1.1	-0.1	-1.1	-1.3	-0.9
Heel T-Score	0.1	0.4	1.3	-0.4	-1.1	-0.7	0.1	-0.6
BMI	0.2	1.0	2.5	-1.0	-0.4	-1.2	-1.6	0.0
Height	0.2	4.1	7.5	-2.6	0.5	-2.0	-2.7	1.4
Waist Hip Ratio (WHR)	0.8	3.8	10.4	-0.8	-2.0	-0.5	-1.9	-3.2
Systolic Blood Pressure	0.6	3.2	5.6	1.6	-2.2	2.4	0.7	-1.6
Smoking Status	0.2	0.6	1.7	0.7	1.3	0.3	-0.0	0.8
Allergy or Eczema	0.7	1.9	4.0	-0.9	0.5	-1.2	-2.0	1.8
Cardiovascular Disease	0.6	1.9	3.2	1.6	-1.8	1.2	0.4	-1.4
Hypothyroidism (self reported)	0.7	1.6	4.3	-1.2	-1.1	-2.1	0.9	-0.2
Respiratory disease	0.6	1.3	2.5	-1.6	1.1	-1.4	-0.6	0.7
Type 2 Diabetes (T2D) (2018)	1.7	3.2	14.9	0.6	0.9	-0.0	-3.9	-0.1
Lung FEV1/FVC ratio	0.9	4.3	8.9	2.8	0.1	3.0	-1.1	-1.9
Lung FVC	0.1	0.4	1.0	-0.3	-0.8	-1.0	-0.3	0.5
Neuroticism	0.5	1.1	2.6	0.3	-1.2	-0.8	1.6	-0.9
Chronotype (morning person)	4.2	9.7	38.7	2.0	-1.3	2.0	6.2	-0.4
Hair Pigment	0.0	1.1	2.8	1.7	0.1	1.2	1.0	0.5
Tanning	0.1	1.6	2.7	1.6	0.2	1.7	1.5	-0.8
Hand grip strength (left)	0.5	1.4	5.2	-0.5	-1.1	-0.0	-0.2	-2.3
Number of treatments/medications taken	0.6	1.1	2.9	1.1	-1.0	0.4	1.7	-0.6
Average weekly spirits intake	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.5
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.0	-0.3	-0.9	1.0	-0.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.3	0.5	0.3	-0.6	1.8	1.2
Hearing difficulty/problems: Yes	2.8	4.2	9.8	-1.8	2.6	-0.9	0.9	3.1
Relative age of first facial hair	0.3	0.7	2.1	0.0	1.4	0.2	0.1	1.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.6	1.7	0.2	0.3	1.9	1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	1.4	0.2	0.6	0.9	-0.6
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	-0.9	0.4	-1.3	-1.0	-0.8
Systolic blood pressure, automated reading	0.6	1.7	3.0	1.2	-1.3	1.7	0.9	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	3.7	0.1	0.1	0.5	-1.9	-0.5
Angina	0.9	1.2	1.9	1.3	-1.3	1.1	1.4	0.1
Medication for hormone replacement therapy	1.1	1.3	2.4	1.5	-0.6	1.0	1.5	0.6
Vitamin and mineral supplements	0.6	0.8	1.9	0.3	-1.4	0.7	0.7	-1.2
Supplements: Zinc	1.3	1.5	4.4	0.4	2.1	-0.3	0.9	1.4
Medication: Co-codamol	0.6	0.7	2.0	0.2	0.2	0.0	1.1	1.4
Medication: Metformin	1.3	1.9	5.3	0.7	2.3	0.1	-1.6	0.9
Diabetes (father)	0.4	0.5	1.8	0.2	-0.1	0.1	-1.3	0.7
Diabetes (mother)	2.0	2.6	7.2	-1.3	0.5	-1.9	-2.7	-0.1
Severe depression (siblings)	1.2	1.4	4.0	-0.3	2.0	-0.6	-0.3	1.5
Pack years adult smoking proportion	0.7	1.0	1.6	1.1	-0.1	1.1	1.3	-1.0
Impedance of leg (right)	1.0	4.9	13.4	0.8	3.7	1.2	0.9	2.9
Leg fat-free mass (left)	1.1	5.9	10.6	-3.2	-0.7	-2.9	-3.0	-1.1
Trunk fat percentage	1.1	4.4	11.0	-1.4	2.3	-1.7	-1.1	3.3
Hand grip strength (right)	0.4	1.1	3.2	-0.5	-1.8	0.1	0.4	-1.3
Townsend deprivation index at recruitment	0.4	0.5	0.8	0.6	-0.9	0.5	0.9	-0.7
Current tobacco smoking	0.1	0.2	0.4	0.3	0.5	0.6	-0.4	-0.1
Average weekly fortified wine intake	0.2	0.3	0.8	-0.2	0.5	-0.3	0.9	-0.3
Maternal smoking around birth	0.6	0.9	3.0	-0.7	-0.8	-0.1	-0.7	-1.7
Fed-up feelings	0.3	0.5	2.1	-0.4	0.0	-1.5	0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.9	0.2	0.3	0.3	1.3
Relative age voice broke	0.6	0.9	2.7	0.4	0.7	0.4	1.7	0.9
Taking other prescription medications	0.7	1.0	4.0	0.9	-0.1	-0.0	2.0	-0.5
Age when periods started (menarche)	0.4	1.0	2.8	-0.3	-1.4	-0.2	-0.6	-1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	0.1	-0.5	0.2	1.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.2	-1.0	0.4	-1.5	-0.6	-0.9
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	9.0	1.8	0.3	1.3	3.0	1.5
Qualifications: CSEs or equivalent	3.4	4.5	10.4	-0.8	3.0	0.6	1.4	3.2
Serious illness, injury or assault to yourself	0.8	0.9	2.3	0.1	0.2	-0.3	1.5	-1.5
High blood pressure	0.5	1.3	2.8	1.1	-1.7	0.7	-0.0	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.1	-0.1	-0.3	-0.4	-1.5	1.0
Multivitamins +/- minerals	0.3	0.4	1.9	0.1	0.3	-0.1	-1.4	0.4
Stomach or abdominal pain in last month	0.5	0.6	1.0	1.0	0.7	1.0	0.3	0.5
Supplements: Glucosamine	1.0	1.3	4.1	-0.4	1.2	-0.8	0.1	2.0
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.9	0.6	1.9	0.5	2.6	2.0
Medication: Atenolol	0.3	0.3	1.0	0.7	-1.0	0.2	0.4	-0.1
Medication: Levothyroxine sodium	0.8	1.4	4.0	-1.4	-0.8	-2.0	0.5	0.4
Sitting height	1.2	8.6	16.5	-3.9	-1.7	-2.7	-4.1	-0.9
Chronic bronchitis/emphysema (father)	0.2	0.3	0.9	-0.3	-0.4	-0.5	0.2	0.9
High blood pressure (mother)	0.3	0.5	1.3	-0.9	-0.1	-0.1	-0.4	1.1
Body mass index (BMI)	0.5	1.9	3.8	-1.5	0.2	-1.9	-1.9	0.3
Impedance of leg (left)	0.9	4.2	9.5	1.0	2.9	1.2	0.6	3.1
Leg predicted mass (left)	1.2	6.3	11.4	-3.4	-0.7	-3.0	-3.1	-1.1
Trunk fat mass	0.9	3.8	5.6	-1.8	1.6	-2.0	-1.9	2.4
Waist circumference	0.8	2.8	5.7	-2.1	0.3	-2.4	-2.0	-0.1
Number of incorrect matches in round	0.2	0.3	0.9	0.7	0.9	0.2	-0.3	0.4
Past tobacco smoking	0.3	0.6	1.1	0.4	-0.6	1.0	1.0	0.7
Alcohol usually taken with meals	0.9	1.5	4.5	2.1	-0.2	1.7	0.1	0.4
Nervous feelings	0.8	1.5	3.0	1.7	-0.9	1.1	1.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.0	-0.4	-0.6	0.8	-0.1
Hearing difficulty/problems with background noise	3.5	5.6	13.9	-1.2	3.7	-0.6	1.4	3.3
Hair/balding pattern: Pattern 2	1.9	2.5	5.7	0.2	1.8	0.1	2.4	1.9
Had menopause	0.8	1.0	2.1	1.1	-1.2	0.3	-0.4	-1.4
Had other major operations	0.2	0.3	0.7	-0.1	0.8	-0.8	0.1	0.3
Forced vital capacity (FVC)	0.6	2.4	4.4	-1.7	-1.0	-1.2	-2.1	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	-0.5	0.1	-0.8	-0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	6.3	-0.9	-0.3	-1.3	-2.5	1.8
Qualifications: None of the above	0.7	1.6	2.8	0.9	-1.4	0.6	1.5	-1.7
Financial difficulties in last 2 years	0.5	0.7	1.6	-0.5	-0.6	-0.8	-1.3	-0.7
Mouth/teeth dental problems	0.2	0.3	0.9	0.6	0.3	-0.2	1.0	0.1
Heart attack	0.8	1.0	4.1	0.2	-2.0	0.0	0.0	-1.0
Allergy	0.1	0.2	0.7	-0.1	0.1	0.4	0.8	-0.3
Pain all over the body in last month	0.4	0.4	1.0	0.9	-0.1	1.0	0.3	-0.1
Diabetes (self-reported)	2.1	3.2	14.3	0.0	1.1	-0.6	-3.8	0.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	6.1	-1.0	0.4	-1.1	-2.5	1.0
Medication: Ramipril	1.0	1.2	3.9	0.4	-1.4	0.1	-0.0	-2.0
Medication: Simvastatin	0.9	1.3	3.7	1.9	-0.7	1.2	0.7	-0.7
Fluid intelligence score	0.5	1.1	2.7	-1.6	0.4	-1.5	-0.7	-0.0
Illnesses of siblings	0.6	0.9	1.2	-0.7	1.1	-0.8	-1.0	1.1
Neuroticism score	0.6	1.2	5.3	0.3	-0.4	-0.7	2.3	0.2
Weight	1.0	5.0	8.9	-2.8	0.4	-2.8	-3.0	0.5
Impedance of arm (right)	1.7	7.9	20.8	0.1	3.3	0.1	2.8	4.6
Arm fat percentage (right)	0.6	2.3	4.5	-0.9	1.5	-1.6	-1.2	2.1
Trunk fat-free mass	1.6	9.0	17.5	-3.2	-1.8	-2.8	-4.2	-2.5
Hip circumference	0.7	3.1	4.6	-1.7	1.5	-2.1	-1.6	1.8
Time employed in main current job	0.8	0.9	2.0	1.4	-0.1	1.2	-0.1	1.0
Alcohol intake versus 10 years previously	0.5	0.7	1.8	0.2	0.1	0.4	-1.4	1.2
Father’s age at death	1.2	1.6	5.4	0.3	-1.6	-0.3	-0.1	-2.3
Worrier / anxious feelings	0.5	0.9	2.7	-0.5	-0.7	-1.0	1.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.2	-0.1	-0.3	-0.3	-0.4
Falls in the last year	0.5	0.7	1.4	1.2	-0.5	0.9	0.1	-0.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.6	0.2	0.3	0.0	0.2
Number of live births	1.5	2.1	5.8	1.1	-1.3	0.9	1.0	-2.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.2	-1.3	-0.6	-0.6	-1.5	1.5
Pulse rate	0.8	1.3	5.5	-0.5	0.6	-0.4	-2.3	0.3
Happiness	0.3	0.3	0.6	0.7	-0.2	0.1	0.8	0.8
Noisy workplace	1.1	1.3	3.2	-1.8	-0.6	-1.5	-0.7	-0.4
Qualifications: A levels/AS levels or equivalent	1.4	3.1	4.7	-2.2	1.3	-2.2	-0.6	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.1	0.4	-0.1	-1.0	-0.1
Mouth/teeth dental problems: Dentures	1.0	1.6	3.5	-1.1	-0.3	-0.3	-1.8	-1.9
Asthma	0.1	0.1	0.2	0.2	0.4	-0.5	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.3	-1.1	1.1	-0.5	0.4	0.7
Medication: Cholesterol lowering	0.3	0.4	1.8	1.3	-0.1	0.5	-0.2	-0.4
Depression (self-reported)	0.5	0.6	2.5	0.5	0.1	-0.3	1.6	0.5
Medication: Lansoprazole	0.6	0.7	0.9	1.0	0.9	0.8	-0.9	0.3
Prospective memory result	0.4	0.5	1.1	-1.0	0.1	-0.9	-0.8	0.5
Lung cancer (father)	1.5	1.7	4.9	-1.0	-2.2	-0.9	0.5	-1.3
Illnesses of mother	0.4	0.4	0.6	-0.7	0.8	-0.5	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.6	-1.0	-0.5	-0.4	-1.3	0.7
Pulse wave Arterial Stiffness index	1.1	1.3	2.3	-1.5	-1.0	-1.3	-1.2	0.4
Impedance of arm (left)	1.8	8.3	21.4	0.1	3.5	0.3	2.8	4.6
Arm fat mass (right)	0.7	2.8	4.5	-1.8	0.9	-2.1	-2.1	1.2
Trunk predicted mass	1.6	9.0	17.5	-3.2	-1.7	-2.8	-4.2	-2.5
Standing height	0.5	4.9	10.3	-3.2	0.5	-2.3	-2.9	0.6
Length of working week for main job	1.4	1.5	5.2	-0.4	-2.3	-0.4	0.9	-1.2
Exposure to tobacco smoke at home	0.5	0.6	2.5	-0.5	0.1	-0.1	-0.4	-1.6
Breastfed as a baby	0.3	0.4	1.4	0.2	0.1	0.2	-1.2	0.5
Tense / ‘highly strung’	1.4	2.4	5.0	2.2	-0.1	1.5	1.8	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	4.8	1.3	-0.7	0.7	2.2	-0.3
Hair/balding pattern: Pattern 4	0.4	1.0	1.5	1.2	-1.2	0.6	1.1	0.7
Birth weight of first child	1.4	2.6	6.8	-0.3	2.6	0.1	1.4	2.1
Peak expiratory flow (PEF)	0.7	1.6	4.6	-2.1	-0.4	-1.4	-0.9	0.4
Pulse wave reflection index	0.3	0.3	1.4	-0.1	-1.2	-0.1	-0.4	0.4
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.8	-0.3	1.3	-0.4	-0.6	1.2
Loud music exposure frequency	0.6	0.7	1.4	-0.7	0.3	-0.8	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.9	-1.7	1.2	-1.2	-0.9	1.1
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.8	1.7	-0.6	2.4	1.4	0.4
Blood clot in the leg (DVT)	0.3	0.4	1.4	-0.7	0.5	-1.2	0.0	0.2
Medication: Paracetamol	0.3	0.5	1.9	-0.5	0.3	-0.1	-0.2	1.4
Headache pain in last month	0.3	0.5	1.0	-0.9	-0.5	-1.0	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.8	-0.9	-0.2	-0.3	-0.1	0.2
Glaucoma (self-reported)	0.9	1.1	4.1	-0.5	0.3	-0.9	-2.0	-0.5
Gout (self-reported)	0.6	0.9	2.6	1.6	1.0	0.8	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	-0.7	-1.4	-1.6	0.6	-0.1
Medication: Amlodipine	0.5	0.6	1.4	1.0	-1.2	0.5	0.5	0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.9	-0.5	-1.1	-0.6	-0.2	-1.7
Birth weight	0.7	1.4	2.6	-1.1	1.6	-1.6	0.1	0.9
Chronic bronchitis/emphysema (mother)	1.7	2.0	7.5	-0.5	-2.7	-0.5	0.0	-1.4
High blood pressure (siblings)	0.3	0.4	1.1	0.7	-0.4	0.6	1.0	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	-0.9	-0.6	-0.4	-1.4	1.0
Body fat percentage	0.8	3.2	7.7	-0.9	2.0	-1.4	-1.2	2.8
Leg fat percentage (right)	0.5	1.7	2.7	-0.5	1.5	-0.9	-1.6	1.5
Arm fat-free mass (right)	1.4	7.1	15.4	-2.7	-1.5	-2.1	-3.9	-2.4
Exposure to tobacco smoke outside home	0.7	0.9	2.8	-0.1	0.2	1.1	0.7	-1.7
Comparative body size at age 10	0.8	2.1	5.5	-0.4	-2.2	-0.6	2.3	-0.0
Number of full brothers	1.4	1.8	6.0	0.3	-1.6	-0.4	0.3	-2.4
Worry too long after embarrassment	0.8	1.3	3.1	-0.3	0.7	-0.4	1.7	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.6	0.8	-0.2	-0.1	0.5	-0.2
Wheeze or whistling in the chest in last year	0.7	1.3	3.8	-0.8	2.0	-1.0	0.2	1.0
Number of children fathered	0.3	0.3	0.9	0.4	-1.0	0.1	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	1.0	-0.3	0.5	-0.2	-0.1
Age at first live birth	2.3	4.0	8.2	-2.9	1.1	-1.9	-1.9	1.7
Pulse wave peak to peak time	1.0	1.2	2.0	1.4	0.8	1.2	1.2	-0.5
Health satisfaction	0.6	0.7	1.3	1.1	-0.6	0.8	1.1	-0.6
Shortness of breath walking on level ground	0.3	0.4	1.3	0.5	-0.5	0.3	0.1	-1.1
Qualifications: College or University degree	0.4	1.1	2.9	0.6	-1.7	1.0	-0.2	-1.1
Eye problems/disorders: None of the above	1.7	2.0	6.9	-0.4	-0.2	-0.6	2.6	1.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	0.1	-0.9	0.8	-1.2	-0.3
Emphysema/chronic bronchitis	0.7	0.8	1.7	-1.3	-0.1	-1.0	0.9	0.7
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	0.9	0.3	0.7	-1.1	-0.0
Neck or shoulder pain in last month	1.5	2.2	3.2	1.6	-1.1	1.5	1.3	-1.8
Medication: Blood pressure	0.2	0.4	0.7	-0.4	-0.5	-0.6	-0.7	-0.8
Angina (self-reported)	0.8	1.1	1.9	1.1	-1.2	0.8	1.4	0.2
Migraine (self-reported)	0.9	1.1	3.5	-1.1	0.6	-1.9	0.2	0.6
Medication: Ibuprofen	0.3	0.4	1.0	-1.0	0.5	-0.7	-0.2	0.1
Medication: Allopurinol	0.5	0.6	1.3	0.9	0.6	0.8	-0.1	-1.1
Medication: Omeprazole	0.8	1.0	1.8	1.4	-0.5	1.1	1.2	0.2
Medication: Seretide 50 evohaler	0.4	0.4	1.6	-0.0	0.4	-0.2	1.3	-0.5
Mean time to correctly identify matches	0.2	0.4	0.6	-0.7	0.7	-0.6	-0.7	-0.2
Heart disease (mother)	0.9	1.1	1.6	1.2	-1.1	1.0	-0.1	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	2.8	-0.4	-1.7	-0.1	0.1	-0.5
Whole body fat mass	0.8	3.4	5.2	-1.7	1.3	-2.0	-2.3	1.8
Leg fat mass (right)	0.7	2.6	6.3	-1.5	1.0	-1.7	-2.5	0.8
Arm predicted mass (right)	1.3	6.9	15.4	-2.7	-1.2	-2.2	-3.9	-2.4
Pulse rate, automated reading	0.2	0.5	1.6	-0.2	-0.6	-0.3	-0.8	-1.3
Alcohol intake frequency.	0.6	1.4	2.2	-1.0	-1.2	-1.0	-1.1	-1.5
Comparative height size at age 10	0.8	4.6	7.1	-2.7	1.8	-2.5	-1.3	2.2
Number of full sisters	1.6	2.0	5.3	0.7	-1.7	1.0	-0.4	-2.3
Suffer from ‘nerves’	0.5	0.8	1.7	1.3	-0.4	0.8	1.3	-0.3
Overall health rating	0.2	0.4	1.0	0.8	0.1	0.6	1.0	0.1
Chest pain or discomfort	0.7	1.0	3.7	0.4	0.7	0.8	1.9	-0.1
Had major operations	0.1	0.2	0.4	-0.6	-0.5	-0.3	-0.3	-0.0
Age at last live birth	2.1	3.0	7.0	-2.7	0.5	-2.1	-1.5	1.0
Family relationship satisfaction	0.5	0.6	1.6	0.1	0.4	-0.4	1.3	1.0
Leg pain on walking	0.0	0.0	0.2	0.1	0.2	-0.1	0.0	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	-1.2	0.5	-1.3	-1.0	1.3
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.0	0.6	1.4	1.0	0.6	1.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	0.1	0.1	0.5	0.8	0.3
Medication: Aspirin	0.4	0.5	1.5	-0.6	-0.5	-1.2	0.6	-0.4
Supplements: Vitamin C	1.9	2.3	4.4	-1.5	2.1	-1.5	0.8	1.3
Knee pain experienced in last month	0.5	0.8	2.5	-0.2	1.6	0.0	0.5	1.1
Hypertension (Self-reported)	0.5	1.3	2.8	1.0	-1.5	0.6	-0.3	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.2	1.4	1.5	0.8	0.4	1.0
Illnesses of father: Heart disease	0.4	0.6	1.1	0.7	-1.0	0.7	-0.8	0.4
Illnesses of siblings: Diabetes	0.8	0.9	2.3	0.8	-0.6	-0.1	-1.2	-1.5
Smoking status: Previous	0.3	0.4	1.5	-0.4	0.4	-1.2	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.0	-0.9	1.7	-0.6	-0.2	2.2
Whole body fat-free mass	1.5	8.4	15.8	-3.4	-1.4	-3.0	-4.0	-2.0
Leg fat-free mass (right)	1.1	6.0	9.7	-3.1	-1.4	-2.8	-3.0	-1.2
Arm fat percentage (left)	0.5	2.0	4.3	-0.8	1.4	-1.4	-1.0	2.1
Average weekly red wine intake	0.5	0.8	2.8	1.7	-0.3	0.8	0.2	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	1.0	-0.5	0.3	0.7	-1.1
Mood swings	0.6	1.1	5.1	0.4	-0.2	-0.3	2.3	-0.5
Loneliness, isolation	1.2	1.6	2.6	1.3	-1.6	0.7	1.2	-1.4
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.7	0.7	-0.2	1.3	0.3
Ever had bowel cancer screening	0.5	0.6	2.3	0.3	1.5	-0.1	0.7	0.1
Diabetes diagnosed by doctor	1.7	2.7	12.8	0.8	0.3	-0.2	-3.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.3	0.6	-0.1	-0.0	-0.8	-1.5
Friendships satisfaction	1.5	1.9	6.0	1.5	0.5	0.8	2.4	0.6
Qualifications: nursing, teaching	2.5	3.9	8.6	-1.6	2.9	-1.2	-0.7	2.5
Commuting to job workplace: Walk	0.2	0.2	0.6	0.1	-0.7	0.2	0.1	0.8
Eye problems/disorders: Cataract	1.2	1.4	3.6	0.5	-0.4	0.3	-1.7	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	-0.9	-0.4	-1.0	-1.4	-0.2
Medication for cholesterol	0.8	1.2	2.8	-1.3	1.7	-0.8	-0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.6	1.6	-0.5	1.5	0.7	-0.4
Back pain experienced in last month	0.3	0.4	1.4	0.1	0.0	-0.4	0.6	1.2
Mineral and other dietary supplements	1.2	1.7	4.0	-0.1	-2.0	0.3	-0.5	-2.0
Breast cancer (self-reported)	1.5	1.8	4.2	0.4	1.7	0.3	2.0	1.3
Asthma (self-reported)	0.1	0.2	0.4	0.0	0.4	-0.6	0.2	-0.6
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.6	1.1	-1.1	0.1	0.7
Osteoarthritis (self-reported)	0.8	1.0	2.3	-0.6	1.1	-0.6	1.5	0.9
Medication: Aspirin	0.7	1.0	2.2	-1.0	-0.7	-1.5	-0.1	-1.1
Medication: Gliclazide	2.1	2.3	6.8	-1.3	1.1	-1.4	-2.6	0.2
Illnesses of father: None of the above (group 1)	2.3	2.9	7.0	-2.6	0.8	-2.4	-0.7	-0.8
Smoking status: Current	0.1	0.2	0.5	0.4	0.4	0.7	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.6	-0.1	-0.8	0.2	-0.1	-0.1
Whole body water mass	1.4	7.7	14.2	-3.2	-1.5	-2.8	-3.8	-2.1
Leg predicted mass (right)	1.1	6.1	9.9	-3.1	-1.4	-2.8	-3.0	-1.2
Arm fat mass (left)	0.7	2.8	4.7	-1.8	0.8	-2.2	-2.0	1.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.0	1.5	1.3	0.6	1.7	1.0
Average weekly champagne plus white wine intake	1.0	1.4	5.1	0.2	-1.3	0.2	-0.4	-2.2
Miserableness	0.4	0.7	1.3	-0.6	0.4	-1.0	1.1	0.7
Guilty feelings	1.4	2.1	3.7	-1.5	-1.0	-1.9	-0.6	-1.8
Wears glasses or contact lenses	0.4	0.4	1.5	-0.1	-0.4	-1.2	-0.7	-0.1
Ever taken oral contraceptive pill	0.3	0.4	1.1	-1.1	0.4	-0.5	-0.5	-0.3
Hearing aid user	0.8	0.9	3.0	0.4	0.1	0.9	1.7	0.8
Mother’s age at death	0.1	0.1	0.4	0.6	0.1	0.1	-0.2	0.2
Financial situation satisfaction	0.1	0.1	0.3	0.4	-0.1	0.0	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.4	-0.3	0.5	0.1	-0.6	0.3
Commuting to job workplace: Public transport	1.0	1.2	2.6	1.6	0.1	1.4	0.2	-1.1
Eye problems/disorders: Glaucoma	1.9	2.3	8.8	-0.8	-0.6	-0.9	-3.0	-0.9
Medication: Blood pressure	0.3	0.6	1.9	0.2	-1.4	-0.2	-0.3	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.9	0.1	1.1	0.4	1.0	1.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.8	0.3	1.3	0.2	0.6	1.0
High cholesterol (Self-reported)	2.7	4.8	10.6	3.3	-1.4	2.4	2.2	-0.5
Medication: Bendroflumethiazide	0.2	0.4	1.8	0.2	-1.3	0.2	-0.0	-0.2
Medication: Paracetamol	0.3	0.5	1.0	-1.0	-0.7	-0.7	-0.5	0.7
Medication: Lisinopril	1.2	1.6	2.6	1.5	-1.3	1.6	-0.1	-1.2
Medication: Atorvastatin	0.6	0.8	2.6	0.1	0.9	-0.3	1.6	0.5
Illnesses of father: High blood pressure	0.5	0.7	1.1	0.9	-1.1	0.9	-0.6	0.4
Alcohol drinker status: Never	0.2	0.2	0.4	0.3	-0.6	0.2	0.6	-0.3
Ever smoked	0.2	0.3	0.7	0.6	0.5	0.1	-0.5	-0.8
Basal metabolic rate	1.4	7.5	14.3	-3.4	-1.0	-3.0	-3.8	-1.4
Leg fat percentage (left)	0.4	1.4	2.8	-0.4	0.9	-0.8	-1.7	1.6
Arm fat-free mass (left)	1.3	6.8	15.4	-2.7	-1.1	-2.5	-3.9	-1.9
Number of operations (self-reported)	0.1	0.2	0.3	0.3	-0.4	-0.4	0.5	0.2
Average weekly beer plus cider intake	1.0	1.4	3.8	-0.8	2.0	0.5	-0.1	1.5
Irritability	0.8	1.4	2.3	-0.6	-0.1	-1.5	1.5	1.5
Risk taking	0.7	1.0	3.5	1.0	-0.2	0.3	-0.5	-1.9
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	0.8	-1.3	0.6	-1.1	-0.7
Fractured/broken bones in last 5 years	1.4	1.9	3.5	-0.9	-1.9	-1.3	-0.5	-1.8
Age started oral contraceptive pill	0.3	0.4	1.3	-1.1	0.1	-0.8	0.4	0.3
Diastolic blood pressure, automated reading	0.8	2.6	4.9	1.7	0.6	1.4	2.2	1.7
Ever depressed for a whole week	0.9	1.1	4.9	0.2	-0.2	-0.1	-0.7	2.2
Unable to work because of sickness or disability	1.3	1.7	3.5	1.9	-0.1	1.2	1.9	-0.0
Commuting to job workplace: Cycle	2.9	3.5	6.7	1.7	1.3	1.8	2.6	1.8
Myopia	1.1	1.6	2.7	1.4	0.5	1.7	1.2	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.2	-1.1	1.5	-0.6	-0.1	1.2
Cholesterol lowering medication	0.7	1.0	2.2	1.0	-1.2	0.8	1.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.8	-0.5	0.9	0.8	-0.1
Pain experienced in last month	0.1	0.1	0.5	-0.4	-0.1	-0.0	-0.0	-0.7
Supplements: Calcium	2.0	2.2	5.1	0.5	2.3	-0.3	0.8	2.2
Basal cell carcinoma (self-reported)	0.8	1.0	1.3	1.1	0.1	1.1	1.1	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.8	0.3	-1.7	0.1	0.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	-0.8	0.7	-1.3	0.0	-0.1
Heart disease (siblings)	0.5	0.6	1.2	1.1	-0.1	0.9	0.9	0.2
Alcohol drinker status: Previous	0.8	1.0	3.8	-0.3	-0.4	-0.8	2.0	-0.2
Pack years of smoking	1.1	1.6	3.2	1.4	-0.2	1.4	1.8	-1.1
Impedance of whole body	1.5	7.5	19.0	0.6	3.5	1.0	2.3	4.4
Leg fat mass (left)	0.7	2.6	6.5	-1.5	0.6	-1.7	-2.5	0.8
Arm predicted mass (left)	1.3	6.6	14.7	-2.8	-1.0	-2.5	-3.8	-1.7