[Hub]/) : Traits : Chronotype (morning person) :

chr1:149,672,809-151,659,071

Best TWAS P=3.68e-16 · Best GWAS P=6.27e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GOLPH3L 0.15 0.27 lasso 11 0.27 1.5e-32 -5.57 5.5 4.7e-08 -0.07 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex MRPS21 0.06 0.04 lasso 7 0.04 5.7e-06 7.55 6.7 2.4e-11 0.89 0.02 0.98 TRUE
3 CommonMind Brain Pre-frontal Cortex RPRD2 0.06 0.04 lasso 3 0.02 7.9e-04 7.64 -7.1 9.8e-13 -0.94 0.02 0.98 FALSE
4 GTEx Adipose Subcutaneous TARS2 0.06 0.02 enet 8 0.03 2.2e-03 7.71 -7.7 1.7e-14 -0.96 0.01 0.98 FALSE
5 GTEx Adipose Visceral Omentum TARS2 0.09 0.08 enet 11 0.06 3.4e-04 7.64 -8.1 3.7e-16 -0.99 0.01 0.98 TRUE
6 GTEx Artery Aorta ADAMTSL4 0.17 0.14 lasso 4 0.10 3.7e-06 -5.52 5.9 3.4e-09 0.51 0.80 0.15 FALSE
7 GTEx Artery Aorta MRPS21 0.09 0.08 lasso 4 0.06 5.1e-04 -6.49 6.8 1.2e-11 0.62 0.24 0.09 FALSE
8 GTEx Artery Aorta RP11-54A4.2 0.12 0.13 lasso 2 0.11 7.7e-07 -5.52 5.5 2.9e-08 0.45 0.66 0.22 FALSE
9 GTEx Artery Tibial ADAMTSL4 0.10 0.06 lasso 4 0.08 6.4e-07 -5.48 7.1 9.6e-13 0.69 0.80 0.13 FALSE
10 GTEx Artery Tibial RP11-54A4.2 0.10 0.07 lasso 4 0.09 1.3e-07 -5.48 7.3 2.0e-13 0.71 0.76 0.21 FALSE
11 GTEx Brain Cortex RP11-316M1.12 0.15 0.18 lasso 6 0.13 1.8e-04 -5.57 5.6 2.5e-08 -0.07 0.80 0.01 FALSE
12 GTEx Brain Nucleus accumbens basal ganglia RP11-316M1.12 0.36 0.31 lasso 8 0.32 3.3e-09 -4.71 5.6 2.7e-08 -0.09 0.98 0.00 FALSE
13 GTEx Brain Putamen basal ganglia ECM1 0.38 -0.01 lasso 9 -0.01 4.4e-01 7.70 -6.4 1.2e-10 -0.74 0.02 0.56 FALSE
14 GTEx Breast Mammary Tissue TARS2 0.18 0.05 lasso 3 0.07 2.5e-04 7.77 -7.4 1.8e-13 -1.00 0.01 0.98 FALSE
15 GTEx Breast Mammary Tissue SETDB1 0.06 0.01 enet 7 0.04 3.9e-03 -5.57 5.5 3.1e-08 0.13 0.24 0.03 FALSE
16 GTEx Breast Mammary Tissue (Male) SETDB1 0.13 0.00 enet 7 0.04 3.8e-02 -4.62 6.4 1.6e-10 0.04 0.08 0.06 TRUE
17 GTEx Breast Mammary Tissue (Female) TARS2 0.18 0.13 lasso 3 0.12 2.7e-04 7.70 -7.7 1.4e-14 -0.99 0.01 0.92 FALSE
18 GTEx Cells Transformed fibroblasts ADAMTSL4 0.08 0.01 lasso 4 0.01 2.6e-02 -5.48 5.3 9.2e-08 0.50 0.47 0.04 FALSE
19 GTEx Cells Transformed fibroblasts RP11-54A4.2 0.08 0.01 lasso 8 0.02 1.8e-02 -6.21 5.8 6.4e-09 0.60 0.55 0.04 FALSE
20 GTEx Esophagus Mucosa ECM1 0.14 0.10 lasso 10 0.12 2.2e-08 -5.52 7.1 1.3e-12 0.61 0.95 0.04 FALSE
21 GTEx Esophagus Mucosa ADAMTSL4 0.40 0.40 lasso 5 0.41 5.8e-29 -5.52 6.2 7.6e-10 0.54 1.00 0.00 FALSE
22 GTEx Esophagus Mucosa GOLPH3L 0.14 0.14 lasso 9 0.13 5.6e-09 -5.60 -5.2 1.6e-07 0.09 1.00 0.00 FALSE
23 GTEx Esophagus Mucosa RP11-54A4.2 0.35 0.33 enet 15 0.34 1.6e-23 -5.52 7.1 1.7e-12 0.59 1.00 0.00 FALSE
24 GTEx Esophagus Muscularis MRPS21 0.14 0.15 enet 13 0.16 7.2e-10 -6.41 6.0 1.8e-09 0.56 0.99 0.01 FALSE
25 GTEx Heart Left Ventricle CERS2 0.08 0.02 enet 9 0.03 1.7e-02 -4.63 5.8 6.2e-09 -0.01 0.19 0.08 FALSE
26 GTEx Lung MRPS21 0.19 0.09 enet 12 0.17 4.3e-13 -6.38 5.8 5.1e-09 0.49 1.00 0.00 FALSE
27 GTEx Muscle Skeletal TARS2 0.11 0.09 lasso 1 0.07 8.5e-08 -6.38 -6.4 1.8e-10 -0.67 0.97 0.03 FALSE
28 GTEx Nerve Tibial C1orf54 0.16 0.02 enet 13 0.08 3.0e-06 6.96 -5.1 2.7e-07 -0.35 0.36 0.14 FALSE
29 GTEx Nerve Tibial SETDB1 0.13 0.07 enet 30 0.12 8.6e-09 -4.68 5.8 7.2e-09 0.21 0.91 0.01 FALSE
30 GTEx Nerve Tibial GOLPH3L 0.33 0.52 lasso 5 0.50 1.6e-40 -5.47 -5.5 3.1e-08 0.09 1.00 0.00 FALSE
31 GTEx Pituitary MRPS21 0.37 0.36 enet 19 0.37 2.7e-10 -6.41 5.7 1.5e-08 0.56 0.95 0.03 FALSE
32 GTEx Prostate RP11-316M1.12 0.16 0.23 enet 24 0.21 5.2e-06 -5.47 5.6 2.7e-08 -0.08 0.86 0.01 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic TARS2 0.18 0.10 lasso 2 0.07 7.3e-05 7.78 -7.9 2.9e-15 -1.00 0.01 0.99 FALSE
34 GTEx Skin Not Sun Exposed Suprapubic ANXA9 0.11 0.12 lasso 2 0.13 2.0e-07 5.51 -6.2 4.3e-10 0.03 0.58 0.12 FALSE
35 GTEx Skin Not Sun Exposed Suprapubic GOLPH3L 0.23 0.32 lasso 10 0.31 1.6e-17 -5.56 -5.4 5.2e-08 0.10 1.00 0.00 FALSE
36 GTEx Skin Not Sun Exposed Suprapubic MRPS21 0.09 0.06 lasso 3 0.06 2.6e-04 -5.52 6.4 2.0e-10 0.58 0.42 0.04 FALSE
37 GTEx Skin Not Sun Exposed Suprapubic RP11-316M1.12 0.19 0.37 lasso 2 0.38 7.6e-22 -4.82 5.1 2.9e-07 -0.13 1.00 0.00 FALSE
38 GTEx Skin Sun Exposed Lower leg ANXA9 0.12 0.04 lasso 3 0.08 3.8e-07 5.64 -6.4 1.7e-10 0.02 0.89 0.09 FALSE
39 GTEx Skin Sun Exposed Lower leg GOLPH3L 0.18 0.36 enet 48 0.39 4.7e-34 -4.65 -5.1 3.1e-07 0.14 1.00 0.00 FALSE
40 GTEx Skin Sun Exposed Lower leg MRPS21 0.07 0.06 enet 9 0.08 1.6e-07 -6.26 6.8 1.1e-11 0.69 0.87 0.09 TRUE
41 GTEx Testis ANXA9 0.30 0.19 enet 22 0.15 2.7e-07 5.64 -6.0 2.5e-09 -0.13 0.83 0.10 TRUE
42 GTEx Testis RPRD2 0.33 0.13 lasso 7 0.19 9.1e-09 7.71 -5.6 1.8e-08 -0.82 0.02 0.98 TRUE
43 GTEx Thyroid SETDB1 0.03 0.02 enet 9 0.01 2.9e-02 -4.88 5.1 3.0e-07 -0.10 0.60 0.02 FALSE
44 GTEx Thyroid ANXA9 0.10 0.06 lasso 3 0.05 2.0e-04 7.37 -7.3 3.5e-13 -0.29 0.05 0.80 FALSE
45 GTEx Thyroid MRPS21 0.21 0.22 lasso 7 0.24 2.2e-18 -6.26 6.6 3.0e-11 0.66 1.00 0.00 FALSE
46 GTEx Uterus MRPS21 0.28 0.03 lasso 10 0.05 3.2e-02 -6.39 6.9 6.3e-12 0.56 0.07 0.08 FALSE
47 METSIM Adipose MRPS21 0.06 0.07 lasso 7 0.06 5.1e-10 -6.35 6.3 2.4e-10 0.66 1.00 0.00 FALSE
48 METSIM Adipose TARS2 0.09 0.09 enet 8 0.08 1.6e-12 6.80 -6.5 5.8e-11 -0.82 0.91 0.09 FALSE
49 YFS Blood SETDB1 0.02 0.00 bslmm 310 0.00 6.8e-03 0.26 5.4 5.8e-08 0.22 0.25 0.06 TRUE
50 The Cancer Genome Atlas Bladder Urothelial Carcinoma C1orf54 0.06 0.02 blup 17 0.03 2.5e-03 6.96 -5.5 2.9e-08 -0.85 0.01 0.53 FALSE
51 The Cancer Genome Atlas Bladder Urothelial Carcinoma CTSS 0.05 0.04 lasso 2 0.04 2.0e-04 -5.55 -5.5 3.2e-08 -0.01 0.03 0.95 FALSE
52 The Cancer Genome Atlas Bladder Urothelial Carcinoma HORMAD1 0.22 0.35 lasso 12 0.37 7.6e-33 -5.49 -5.5 3.1e-08 0.09 0.03 0.97 FALSE
53 The Cancer Genome Atlas Breast Invasive Carcinoma CTSS 0.02 0.01 enet 4 0.01 2.8e-03 -5.47 -6.0 1.6e-09 0.08 0.03 0.86 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma HORMAD1 0.06 0.11 lasso 2 0.10 2.0e-20 -5.54 -5.5 3.0e-08 0.10 0.03 0.97 FALSE
55 The Cancer Genome Atlas Colon Adenocarcinoma HORMAD1 0.14 0.14 lasso 7 0.13 4.8e-08 -5.49 -5.6 2.0e-08 0.07 0.03 0.97 FALSE
56 The Cancer Genome Atlas Esophageal Carcinoma C1orf54 0.13 0.08 enet 7 0.11 2.2e-04 -7.20 -7.8 4.2e-15 -0.50 0.00 0.93 TRUE
57 The Cancer Genome Atlas Esophageal Carcinoma HORMAD1 0.31 0.36 enet 32 0.35 7.8e-12 -5.49 -5.7 1.3e-08 0.10 0.03 0.97 FALSE
58 The Cancer Genome Atlas Glioblastoma Multiforme CTSS 0.08 0.03 blup 50 0.07 4.8e-03 -5.55 -5.2 2.3e-07 0.13 0.03 0.65 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ADAMTSL4 0.11 0.07 lasso 4 0.07 1.2e-08 -5.52 6.2 5.3e-10 0.59 0.90 0.10 FALSE
60 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1orf54 0.04 0.04 lasso 2 0.03 2.0e-04 6.96 -7.1 1.5e-12 -0.83 0.01 0.96 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ECM1 0.04 0.04 blup 26 0.04 4.9e-05 -5.52 7.2 5.0e-13 0.68 0.16 0.66 FALSE
62 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HORMAD1 0.27 0.54 lasso 11 0.55 4.2e-74 -5.56 -5.5 4.4e-08 0.07 0.02 0.98 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C1orf54 0.06 0.03 lasso 1 0.03 1.3e-04 6.96 -7.0 3.5e-12 -0.84 0.01 0.82 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CTSS 0.04 0.01 enet 4 0.03 4.7e-04 -2.60 -5.6 2.5e-08 0.09 0.06 0.86 TRUE
65 The Cancer Genome Atlas Brain Lower Grade Glioma CTSS 0.29 0.08 lasso 3 0.08 1.5e-09 5.51 -6.0 1.7e-09 -0.01 0.03 0.96 FALSE
66 The Cancer Genome Atlas Brain Lower Grade Glioma MRPS21 0.13 0.13 enet 10 0.13 1.7e-14 -6.43 5.7 1.3e-08 0.62 0.03 0.97 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma RPRD2 0.03 0.01 blup 19 0.02 2.6e-03 7.64 -6.1 9.8e-10 -0.87 0.00 0.93 FALSE
68 The Cancer Genome Atlas Lung Adenocarcinoma C1orf54 0.04 0.02 blup 17 0.02 1.4e-03 6.96 -6.6 4.8e-11 -0.65 0.01 0.87 FALSE
69 The Cancer Genome Atlas Lung Adenocarcinoma HORMAD1 0.22 0.40 lasso 7 0.41 7.7e-52 -5.49 -5.6 2.1e-08 0.08 0.03 0.97 FALSE
70 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CTSS 0.02 0.01 blup 50 0.02 1.5e-03 -5.57 -5.2 1.7e-07 0.13 0.03 0.83 FALSE
71 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GOLPH3L 0.02 0.02 blup 49 0.01 1.6e-02 -5.46 5.5 3.1e-08 -0.11 0.08 0.18 TRUE
72 The Cancer Genome Atlas Lung Squamous Cell Carcinoma HORMAD1 0.26 0.47 lasso 6 0.46 2.1e-58 -5.60 -5.6 2.2e-08 0.06 0.02 0.98 FALSE
73 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MRPS21 0.04 0.03 blup 15 0.04 4.0e-05 -6.43 6.7 2.5e-11 0.81 0.01 0.93 FALSE
74 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma HORMAD1 0.19 0.09 blup 44 0.12 3.3e-08 -5.56 -5.4 6.9e-08 -0.06 0.03 0.97 FALSE
75 The Cancer Genome Atlas Pancreatic Adenocarcinoma CTSS 0.07 0.07 blup 50 0.07 6.4e-04 -5.48 -5.7 1.1e-08 0.02 0.02 0.84 FALSE
76 The Cancer Genome Atlas Prostate Adenocarcinoma ADAMTSL4 0.07 0.05 blup 33 0.05 5.6e-06 -5.52 7.4 1.5e-13 0.82 0.14 0.85 FALSE
77 The Cancer Genome Atlas Prostate Adenocarcinoma GOLPH3L 0.03 0.01 blup 49 0.01 2.2e-02 -5.47 6.3 3.1e-10 -0.06 0.02 0.71 FALSE
78 The Cancer Genome Atlas Rectum Adenocarcinoma HORMAD1 0.19 0.14 blup 43 0.14 3.3e-04 -5.49 -5.7 1.2e-08 0.08 0.03 0.91 FALSE
79 The Cancer Genome Atlas Soft Tissue Sarcoma HORMAD1 0.14 0.15 blup 44 0.15 3.2e-09 -5.49 -5.8 5.6e-09 0.03 0.03 0.97 FALSE
80 The Cancer Genome Atlas Skin Cutaneous Melanoma HORMAD1 0.16 0.17 blup 44 0.16 4.4e-05 -5.56 -5.4 8.6e-08 0.10 0.03 0.93 FALSE
81 The Cancer Genome Atlas Stomach Adenocarcinoma CTSS 0.04 0.04 blup 48 0.04 6.9e-04 -4.88 -5.3 9.0e-08 0.13 0.03 0.85 FALSE
82 The Cancer Genome Atlas Stomach Adenocarcinoma HORMAD1 0.10 0.15 lasso 6 0.15 5.9e-11 -5.48 -5.5 3.4e-08 0.09 0.03 0.97 FALSE
83 The Cancer Genome Atlas Testicular Germ Cell Tumors HORMAD1 0.26 0.24 lasso 13 0.30 3.2e-11 -4.88 -5.2 2.2e-07 0.10 0.03 0.97 FALSE
84 The Cancer Genome Atlas Thyroid Carcinoma ANXA9 0.10 0.05 lasso 4 0.04 4.1e-05 5.56 -5.4 5.6e-08 -0.07 0.00 1.00 FALSE
85 The Cancer Genome Atlas Thyroid Carcinoma CTSS 0.11 0.23 lasso 8 0.24 1.2e-22 -4.88 -5.2 2.4e-07 0.12 0.04 0.96 FALSE
86 The Cancer Genome Atlas Thyroid Carcinoma GOLPH3L 0.02 0.02 blup 49 0.01 3.0e-02 -5.55 -5.5 3.3e-08 0.06 0.09 0.12 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma HORMAD1 0.19 0.14 lasso 5 0.15 8.3e-15 -5.47 -5.4 5.9e-08 0.11 0.04 0.96 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma TARS2 0.02 0.02 lasso 1 0.01 4.2e-02 7.71 -7.7 1.2e-14 -0.98 0.00 0.90 FALSE
89 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CTSS 0.13 0.03 lasso 8 0.05 1.9e-02 -5.49 -5.2 2.4e-07 0.07 0.02 0.57 FALSE