[Hub]/) : Traits : Chronotype (morning person) : ← →

chr1:149,672,809-151,659,071

Best TWAS P=3.68e-16 · Best GWAS P=6.27e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GOLPH3L	0.15	0.27	lasso	11	0.27	1.5e-32	-5.57	5.5	4.7e-08	-0.07	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPS21	0.06	0.04	lasso	7	0.04	5.7e-06	7.55	6.7	2.4e-11	0.89	0.02	0.98	TRUE
3	CommonMind	Brain Pre-frontal Cortex	RPRD2	0.06	0.04	lasso	3	0.02	7.9e-04	7.64	-7.1	9.8e-13	-0.94	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	TARS2	0.06	0.02	enet	8	0.03	2.2e-03	7.71	-7.7	1.7e-14	-0.96	0.01	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	TARS2	0.09	0.08	enet	11	0.06	3.4e-04	7.64	-8.1	3.7e-16	-0.99	0.01	0.98	TRUE
6	GTEx	Artery Aorta	ADAMTSL4	0.17	0.14	lasso	4	0.10	3.7e-06	-5.52	5.9	3.4e-09	0.51	0.80	0.15	FALSE
7	GTEx	Artery Aorta	MRPS21	0.09	0.08	lasso	4	0.06	5.1e-04	-6.49	6.8	1.2e-11	0.62	0.24	0.09	FALSE
8	GTEx	Artery Aorta	RP11-54A4.2	0.12	0.13	lasso	2	0.11	7.7e-07	-5.52	5.5	2.9e-08	0.45	0.66	0.22	FALSE
9	GTEx	Artery Tibial	ADAMTSL4	0.10	0.06	lasso	4	0.08	6.4e-07	-5.48	7.1	9.6e-13	0.69	0.80	0.13	FALSE
10	GTEx	Artery Tibial	RP11-54A4.2	0.10	0.07	lasso	4	0.09	1.3e-07	-5.48	7.3	2.0e-13	0.71	0.76	0.21	FALSE
11	GTEx	Brain Cortex	RP11-316M1.12	0.15	0.18	lasso	6	0.13	1.8e-04	-5.57	5.6	2.5e-08	-0.07	0.80	0.01	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	RP11-316M1.12	0.36	0.31	lasso	8	0.32	3.3e-09	-4.71	5.6	2.7e-08	-0.09	0.98	0.00	FALSE
13	GTEx	Brain Putamen basal ganglia	ECM1	0.38	-0.01	lasso	9	-0.01	4.4e-01	7.70	-6.4	1.2e-10	-0.74	0.02	0.56	FALSE
14	GTEx	Breast Mammary Tissue	TARS2	0.18	0.05	lasso	3	0.07	2.5e-04	7.77	-7.4	1.8e-13	-1.00	0.01	0.98	FALSE
15	GTEx	Breast Mammary Tissue	SETDB1	0.06	0.01	enet	7	0.04	3.9e-03	-5.57	5.5	3.1e-08	0.13	0.24	0.03	FALSE
16	GTEx	Breast Mammary Tissue (Male)	SETDB1	0.13	0.00	enet	7	0.04	3.8e-02	-4.62	6.4	1.6e-10	0.04	0.08	0.06	TRUE
17	GTEx	Breast Mammary Tissue (Female)	TARS2	0.18	0.13	lasso	3	0.12	2.7e-04	7.70	-7.7	1.4e-14	-0.99	0.01	0.92	FALSE
18	GTEx	Cells Transformed fibroblasts	ADAMTSL4	0.08	0.01	lasso	4	0.01	2.6e-02	-5.48	5.3	9.2e-08	0.50	0.47	0.04	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-54A4.2	0.08	0.01	lasso	8	0.02	1.8e-02	-6.21	5.8	6.4e-09	0.60	0.55	0.04	FALSE
20	GTEx	Esophagus Mucosa	ECM1	0.14	0.10	lasso	10	0.12	2.2e-08	-5.52	7.1	1.3e-12	0.61	0.95	0.04	FALSE
21	GTEx	Esophagus Mucosa	ADAMTSL4	0.40	0.40	lasso	5	0.41	5.8e-29	-5.52	6.2	7.6e-10	0.54	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	GOLPH3L	0.14	0.14	lasso	9	0.13	5.6e-09	-5.60	-5.2	1.6e-07	0.09	1.00	0.00	FALSE
23	GTEx	Esophagus Mucosa	RP11-54A4.2	0.35	0.33	enet	15	0.34	1.6e-23	-5.52	7.1	1.7e-12	0.59	1.00	0.00	FALSE
24	GTEx	Esophagus Muscularis	MRPS21	0.14	0.15	enet	13	0.16	7.2e-10	-6.41	6.0	1.8e-09	0.56	0.99	0.01	FALSE
25	GTEx	Heart Left Ventricle	CERS2	0.08	0.02	enet	9	0.03	1.7e-02	-4.63	5.8	6.2e-09	-0.01	0.19	0.08	FALSE
26	GTEx	Lung	MRPS21	0.19	0.09	enet	12	0.17	4.3e-13	-6.38	5.8	5.1e-09	0.49	1.00	0.00	FALSE
27	GTEx	Muscle Skeletal	TARS2	0.11	0.09	lasso	1	0.07	8.5e-08	-6.38	-6.4	1.8e-10	-0.67	0.97	0.03	FALSE
28	GTEx	Nerve Tibial	C1orf54	0.16	0.02	enet	13	0.08	3.0e-06	6.96	-5.1	2.7e-07	-0.35	0.36	0.14	FALSE
29	GTEx	Nerve Tibial	SETDB1	0.13	0.07	enet	30	0.12	8.6e-09	-4.68	5.8	7.2e-09	0.21	0.91	0.01	FALSE
30	GTEx	Nerve Tibial	GOLPH3L	0.33	0.52	lasso	5	0.50	1.6e-40	-5.47	-5.5	3.1e-08	0.09	1.00	0.00	FALSE
31	GTEx	Pituitary	MRPS21	0.37	0.36	enet	19	0.37	2.7e-10	-6.41	5.7	1.5e-08	0.56	0.95	0.03	FALSE
32	GTEx	Prostate	RP11-316M1.12	0.16	0.23	enet	24	0.21	5.2e-06	-5.47	5.6	2.7e-08	-0.08	0.86	0.01	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	TARS2	0.18	0.10	lasso	2	0.07	7.3e-05	7.78	-7.9	2.9e-15	-1.00	0.01	0.99	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ANXA9	0.11	0.12	lasso	2	0.13	2.0e-07	5.51	-6.2	4.3e-10	0.03	0.58	0.12	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	GOLPH3L	0.23	0.32	lasso	10	0.31	1.6e-17	-5.56	-5.4	5.2e-08	0.10	1.00	0.00	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	MRPS21	0.09	0.06	lasso	3	0.06	2.6e-04	-5.52	6.4	2.0e-10	0.58	0.42	0.04	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	RP11-316M1.12	0.19	0.37	lasso	2	0.38	7.6e-22	-4.82	5.1	2.9e-07	-0.13	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	ANXA9	0.12	0.04	lasso	3	0.08	3.8e-07	5.64	-6.4	1.7e-10	0.02	0.89	0.09	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GOLPH3L	0.18	0.36	enet	48	0.39	4.7e-34	-4.65	-5.1	3.1e-07	0.14	1.00	0.00	FALSE
40	GTEx	Skin Sun Exposed Lower leg	MRPS21	0.07	0.06	enet	9	0.08	1.6e-07	-6.26	6.8	1.1e-11	0.69	0.87	0.09	TRUE
41	GTEx	Testis	ANXA9	0.30	0.19	enet	22	0.15	2.7e-07	5.64	-6.0	2.5e-09	-0.13	0.83	0.10	TRUE
42	GTEx	Testis	RPRD2	0.33	0.13	lasso	7	0.19	9.1e-09	7.71	-5.6	1.8e-08	-0.82	0.02	0.98	TRUE
43	GTEx	Thyroid	SETDB1	0.03	0.02	enet	9	0.01	2.9e-02	-4.88	5.1	3.0e-07	-0.10	0.60	0.02	FALSE
44	GTEx	Thyroid	ANXA9	0.10	0.06	lasso	3	0.05	2.0e-04	7.37	-7.3	3.5e-13	-0.29	0.05	0.80	FALSE
45	GTEx	Thyroid	MRPS21	0.21	0.22	lasso	7	0.24	2.2e-18	-6.26	6.6	3.0e-11	0.66	1.00	0.00	FALSE
46	GTEx	Uterus	MRPS21	0.28	0.03	lasso	10	0.05	3.2e-02	-6.39	6.9	6.3e-12	0.56	0.07	0.08	FALSE
47	METSIM	Adipose	MRPS21	0.06	0.07	lasso	7	0.06	5.1e-10	-6.35	6.3	2.4e-10	0.66	1.00	0.00	FALSE
48	METSIM	Adipose	TARS2	0.09	0.09	enet	8	0.08	1.6e-12	6.80	-6.5	5.8e-11	-0.82	0.91	0.09	FALSE
49	YFS	Blood	SETDB1	0.02	0.00	bslmm	310	0.00	6.8e-03	0.26	5.4	5.8e-08	0.22	0.25	0.06	TRUE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1orf54	0.06	0.02	blup	17	0.03	2.5e-03	6.96	-5.5	2.9e-08	-0.85	0.01	0.53	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CTSS	0.05	0.04	lasso	2	0.04	2.0e-04	-5.55	-5.5	3.2e-08	-0.01	0.03	0.95	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HORMAD1	0.22	0.35	lasso	12	0.37	7.6e-33	-5.49	-5.5	3.1e-08	0.09	0.03	0.97	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSS	0.02	0.01	enet	4	0.01	2.8e-03	-5.47	-6.0	1.6e-09	0.08	0.03	0.86	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	HORMAD1	0.06	0.11	lasso	2	0.10	2.0e-20	-5.54	-5.5	3.0e-08	0.10	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	HORMAD1	0.14	0.14	lasso	7	0.13	4.8e-08	-5.49	-5.6	2.0e-08	0.07	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Esophageal Carcinoma	C1orf54	0.13	0.08	enet	7	0.11	2.2e-04	-7.20	-7.8	4.2e-15	-0.50	0.00	0.93	TRUE
57	The Cancer Genome Atlas	Esophageal Carcinoma	HORMAD1	0.31	0.36	enet	32	0.35	7.8e-12	-5.49	-5.7	1.3e-08	0.10	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSS	0.08	0.03	blup	50	0.07	4.8e-03	-5.55	-5.2	2.3e-07	0.13	0.03	0.65	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ADAMTSL4	0.11	0.07	lasso	4	0.07	1.2e-08	-5.52	6.2	5.3e-10	0.59	0.90	0.10	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf54	0.04	0.04	lasso	2	0.03	2.0e-04	6.96	-7.1	1.5e-12	-0.83	0.01	0.96	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ECM1	0.04	0.04	blup	26	0.04	4.9e-05	-5.52	7.2	5.0e-13	0.68	0.16	0.66	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HORMAD1	0.27	0.54	lasso	11	0.55	4.2e-74	-5.56	-5.5	4.4e-08	0.07	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1orf54	0.06	0.03	lasso	1	0.03	1.3e-04	6.96	-7.0	3.5e-12	-0.84	0.01	0.82	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSS	0.04	0.01	enet	4	0.03	4.7e-04	-2.60	-5.6	2.5e-08	0.09	0.06	0.86	TRUE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSS	0.29	0.08	lasso	3	0.08	1.5e-09	5.51	-6.0	1.7e-09	-0.01	0.03	0.96	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPS21	0.13	0.13	enet	10	0.13	1.7e-14	-6.43	5.7	1.3e-08	0.62	0.03	0.97	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPRD2	0.03	0.01	blup	19	0.02	2.6e-03	7.64	-6.1	9.8e-10	-0.87	0.00	0.93	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf54	0.04	0.02	blup	17	0.02	1.4e-03	6.96	-6.6	4.8e-11	-0.65	0.01	0.87	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	HORMAD1	0.22	0.40	lasso	7	0.41	7.7e-52	-5.49	-5.6	2.1e-08	0.08	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CTSS	0.02	0.01	blup	50	0.02	1.5e-03	-5.57	-5.2	1.7e-07	0.13	0.03	0.83	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GOLPH3L	0.02	0.02	blup	49	0.01	1.6e-02	-5.46	5.5	3.1e-08	-0.11	0.08	0.18	TRUE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HORMAD1	0.26	0.47	lasso	6	0.46	2.1e-58	-5.60	-5.6	2.2e-08	0.06	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRPS21	0.04	0.03	blup	15	0.04	4.0e-05	-6.43	6.7	2.5e-11	0.81	0.01	0.93	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HORMAD1	0.19	0.09	blup	44	0.12	3.3e-08	-5.56	-5.4	6.9e-08	-0.06	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CTSS	0.07	0.07	blup	50	0.07	6.4e-04	-5.48	-5.7	1.1e-08	0.02	0.02	0.84	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADAMTSL4	0.07	0.05	blup	33	0.05	5.6e-06	-5.52	7.4	1.5e-13	0.82	0.14	0.85	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOLPH3L	0.03	0.01	blup	49	0.01	2.2e-02	-5.47	6.3	3.1e-10	-0.06	0.02	0.71	FALSE
78	The Cancer Genome Atlas	Rectum Adenocarcinoma	HORMAD1	0.19	0.14	blup	43	0.14	3.3e-04	-5.49	-5.7	1.2e-08	0.08	0.03	0.91	FALSE
79	The Cancer Genome Atlas	Soft Tissue Sarcoma	HORMAD1	0.14	0.15	blup	44	0.15	3.2e-09	-5.49	-5.8	5.6e-09	0.03	0.03	0.97	FALSE
80	The Cancer Genome Atlas	Skin Cutaneous Melanoma	HORMAD1	0.16	0.17	blup	44	0.16	4.4e-05	-5.56	-5.4	8.6e-08	0.10	0.03	0.93	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	CTSS	0.04	0.04	blup	48	0.04	6.9e-04	-4.88	-5.3	9.0e-08	0.13	0.03	0.85	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	HORMAD1	0.10	0.15	lasso	6	0.15	5.9e-11	-5.48	-5.5	3.4e-08	0.09	0.03	0.97	FALSE
83	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HORMAD1	0.26	0.24	lasso	13	0.30	3.2e-11	-4.88	-5.2	2.2e-07	0.10	0.03	0.97	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	ANXA9	0.10	0.05	lasso	4	0.04	4.1e-05	5.56	-5.4	5.6e-08	-0.07	0.00	1.00	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	CTSS	0.11	0.23	lasso	8	0.24	1.2e-22	-4.88	-5.2	2.4e-07	0.12	0.04	0.96	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	GOLPH3L	0.02	0.02	blup	49	0.01	3.0e-02	-5.55	-5.5	3.3e-08	0.06	0.09	0.12	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	HORMAD1	0.19	0.14	lasso	5	0.15	8.3e-15	-5.47	-5.4	5.9e-08	0.11	0.04	0.96	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	TARS2	0.02	0.02	lasso	1	0.01	4.2e-02	7.71	-7.7	1.2e-14	-0.98	0.00	0.90	FALSE
89	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSS	0.13	0.03	lasso	8	0.05	1.9e-02	-5.49	-5.2	2.4e-07	0.07	0.02	0.57	FALSE