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chr11:46,010,847-48,559,571

Best TWAS P=2.62e-13 · Best GWAS P=6.69e-11 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	6.5	-7.3	2.6e-13	-0.89	0.01	0.99	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	-5.7	-6.2	4.5e-10	-0.34	0.14	0.86	TRUE
29	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-6.2	6.1	7.9e-10	0.46	0.02	0.97	TRUE
3	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	-5.7	5.8	6.4e-09	0.39	0.04	0.95	TRUE
19	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-4.3	5.8	7.9e-09	0.58	0.05	0.92	TRUE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	-6.1	-5.3	1.5e-07	-0.24	0.01	0.66	TRUE
30	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-5.2	-5.2	2.0e-07	-0.34	0.06	0.94	TRUE
15	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-6.3	-6.8	7.6e-12	-0.57	0.02	0.96	FALSE
6	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-4.6	6.7	1.8e-11	0.49	0.10	0.73	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	3.9	-6.6	3.1e-11	-0.60	0.14	0.49	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.1	-6.5	7.8e-11	-0.51	0.01	0.90	FALSE
49	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-6.3	6.3	2.2e-10	0.37	0.00	1.00	FALSE
36	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-6.3	6.3	2.4e-10	0.37	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.3	-6.3	2.5e-10	-0.37	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.3	6.3	2.5e-10	0.37	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.3	6.3	3.0e-10	0.36	0.00	1.00	FALSE
33	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.3	6.2	6.5e-10	0.34	0.01	0.99	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.3	-6.2	6.5e-10	-0.37	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-6.1	-6.1	8.1e-10	-0.36	0.00	0.99	FALSE
32	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-6.1	6.1	8.7e-10	0.35	0.02	0.97	FALSE
35	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	5.0	-6.1	1.0e-09	-0.85	0.05	0.93	FALSE
8	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	4.9	6.0	1.8e-09	0.56	0.04	0.34	FALSE
31	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	5.1	6.0	1.9e-09	0.54	0.68	0.19	FALSE
43	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	5.1	-6.0	2.0e-09	-0.56	0.02	0.80	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-6.4	6.0	2.4e-09	0.36	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue	ARHGAP1	0.05	0.00	enet	14	0.01	1.3e-01	-4.6	5.9	2.8e-09	0.44	0.07	0.51	FALSE
55	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-6.3	5.9	3.3e-09	0.35	0.00	0.93	FALSE
23	GTEx	Prostate	CELF1	0.17	0.16	lasso	2	0.12	6.2e-04	-5.9	-5.9	4.9e-09	-0.29	0.14	0.31	FALSE
7	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-6.2	-5.8	6.1e-09	-0.28	0.03	0.93	FALSE
16	GTEx	Esophagus Muscularis	CKAP5	0.05	0.03	lasso	4	0.04	3.3e-03	-5.4	-5.8	6.9e-09	-0.26	0.16	0.64	FALSE
28	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-4.3	5.7	9.0e-09	0.47	0.05	0.95	FALSE
24	GTEx	Prostate	ZNF408	0.19	0.10	lasso	2	0.10	1.6e-03	-5.8	5.7	9.6e-09	0.28	0.03	0.79	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	3.3	-5.7	1.2e-08	-0.27	0.04	0.70	FALSE
27	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	-5.0	-5.7	1.2e-08	-0.36	0.54	0.46	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	3.6	-5.7	1.2e-08	-0.31	0.02	0.55	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.3	5.7	1.2e-08	0.35	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-5.2	5.7	1.3e-08	0.46	0.01	0.94	FALSE
12	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	4.9	-5.7	1.5e-08	-0.48	0.36	0.64	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP1	0.06	0.01	lasso	9	0.00	2.8e-01	-5.8	5.7	1.6e-08	0.32	0.04	0.76	FALSE
5	GTEx	Artery Tibial	LRP4	0.06	0.00	lasso	5	0.00	6.4e-01	5.0	5.6	1.9e-08	0.32	0.05	0.18	FALSE
34	METSIM	Adipose	DDB2	0.03	0.03	lasso	2	0.02	1.9e-04	-5.4	5.6	2.1e-08	0.25	0.28	0.66	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	5.1	-5.6	2.3e-08	-0.63	0.89	0.11	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-5.3	-5.6	2.5e-08	-0.40	0.04	0.43	FALSE
20	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-5.2	5.5	2.9e-08	0.36	0.03	0.97	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-6.1	-5.5	4.0e-08	-0.35	0.01	0.97	FALSE
17	GTEx	Esophagus Muscularis	ARHGAP1	0.07	0.08	lasso	3	0.07	6.1e-05	-5.4	5.4	5.3e-08	0.26	0.12	0.87	FALSE
4	GTEx	Artery Aorta	CKAP5	0.09	0.12	lasso	1	0.07	1.2e-04	-5.4	-5.4	6.2e-08	-0.23	0.42	0.56	FALSE
13	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-4.4	5.3	8.8e-08	0.34	0.04	0.86	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-5.4	-5.3	9.8e-08	-0.35	0.01	0.96	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	DDB2	0.04	0.03	enet	15	0.03	7.1e-05	-5.8	5.3	1.0e-07	0.20	0.25	0.73	FALSE
21	GTEx	Ovary	ARHGAP1	0.25	0.09	lasso	16	0.18	3.8e-05	-3.6	5.3	1.1e-07	0.31	0.13	0.56	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-4.3	5.3	1.2e-07	0.31	0.06	0.94	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-4.3	5.2	1.5e-07	0.40	0.00	0.96	FALSE
9	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-5.2	5.2	2.6e-07	0.32	0.05	0.84	FALSE
18	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-4.3	5.1	2.7e-07	0.38	0.08	0.92	FALSE