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chr12:108,763,672-110,729,807

Best TWAS P=1.62e-12 · Best GWAS P=1.91e-12 conditioned to 0.125

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MMAB	0.12	0.09	enet	13	0.08	2.9e-10	6.8	-6.5	5.8e-11	-0.69	0.04	0.96	FALSE
2	GTEx	Adipose Visceral Omentum	MMAB	0.10	-0.01	lasso	4	0.00	3.8e-01	-5.7	-5.6	2.8e-08	-0.57	0.10	0.23	FALSE
3	GTEx	Cells Transformed fibroblasts	MMAB	0.07	0.06	enet	9	0.05	7.3e-05	6.6	-7.0	2.0e-12	-0.91	0.01	0.98	FALSE
4	GTEx	Colon Sigmoid	KCTD10	0.25	0.16	lasso	8	0.15	6.2e-06	6.7	-6.2	4.8e-10	-0.63	0.25	0.69	FALSE
5	GTEx	Colon Transverse	KCTD10	0.22	0.12	lasso	11	0.13	1.1e-06	-5.8	-6.5	6.3e-11	-0.72	0.30	0.69	FALSE
6	GTEx	Colon Transverse	MMAB	0.08	0.07	lasso	2	0.05	1.7e-03	6.7	-6.4	1.2e-10	-0.69	0.17	0.60	FALSE
7	GTEx	Muscle Skeletal	MMAB	0.06	0.04	lasso	11	0.05	1.9e-05	5.5	-5.5	3.7e-08	-0.66	0.54	0.41	FALSE
8	GTEx	Nerve Tibial	USP30	0.07	0.01	lasso	4	0.01	1.1e-01	4.9	6.2	5.9e-10	0.81	0.04	0.78	FALSE
9	GTEx	Thyroid	KCTD10	0.06	0.02	enet	12	0.02	9.2e-03	7.0	-5.9	4.2e-09	-0.85	0.01	0.97	FALSE
10	GTEx	Thyroid	MMAB	0.07	0.00	lasso	6	0.02	5.4e-03	-5.7	-6.5	5.8e-11	-0.77	0.09	0.78	FALSE
11	GTEx	Whole Blood	MVK	0.05	0.00	enet	13	0.00	4.8e-01	-5.5	-5.3	1.2e-07	-0.53	0.14	0.06	FALSE
12	YFS	Blood	KCTD10	0.49	0.58	enet	47	0.62	1.1e-266	5.5	5.5	3.0e-08	0.74	0.99	0.01	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMAB	0.03	0.01	blup	57	0.02	6.5e-06	6.7	-6.0	1.8e-09	-0.65	0.02	0.94	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYO1H	0.08	0.12	enet	14	0.10	1.7e-19	5.2	5.4	7.7e-08	0.72	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MMAB	0.05	0.01	blup	57	0.02	5.8e-02	5.4	-6.2	4.9e-10	-0.68	0.03	0.53	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MMAB	0.03	0.02	blup	57	0.02	2.2e-03	6.7	-6.9	7.2e-12	-0.74	0.01	0.91	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MMAB	0.04	0.02	blup	53	0.02	5.2e-03	6.7	-6.6	3.4e-11	-0.67	0.00	0.88	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MMAB	0.09	0.05	blup	57	0.09	6.3e-06	6.7	-6.3	3.0e-10	-0.66	0.02	0.93	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MVK	0.06	0.02	enet	5	0.06	2.1e-04	6.7	-6.1	1.1e-09	-0.57	0.01	0.88	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYO1H	0.05	0.02	blup	87	0.04	2.1e-03	-3.8	5.6	2.3e-08	0.85	0.07	0.53	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	MMAB	0.03	0.02	blup	57	0.02	2.4e-03	5.5	-5.2	1.9e-07	-0.52	0.07	0.08	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	MYO1H	0.13	0.15	lasso	5	0.16	2.2e-18	5.2	5.1	2.7e-07	0.67	0.87	0.13	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MMAB	0.07	0.00	blup	57	0.02	6.6e-03	4.3	-6.0	2.4e-09	-0.59	0.03	0.48	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO1H	0.08	0.04	lasso	3	0.04	3.7e-05	-5.2	5.6	2.0e-08	0.69	0.24	0.73	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MMAB	0.07	0.02	blup	57	0.03	4.5e-03	5.4	-5.7	1.6e-08	-0.59	0.04	0.41	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-5.8	-5.3	1.3e-07	-0.49	0.08	0.92	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	KCTD10	0.15	0.08	lasso	6	0.08	2.1e-08	6.6	-7.1	1.6e-12	-0.90	0.03	0.97	TRUE