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chr22:41,181,586-43,674,249

Best TWAS P=5.07e-11 · Best GWAS P=4e-10 conditioned to 0.00294

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MEI1	0.09	0.10	blup	343	0.10	3.1e-12	-4.3	-6.1	9.9e-10	-0.37	0.97	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RRP7B	0.14	0.07	bslmm	435	0.09	9.3e-11	4.7	5.2	2.6e-07	0.09	0.90	0.10	FALSE
3	GTEx	Adipose Subcutaneous	CCDC134	0.05	0.02	lasso	4	0.01	2.1e-02	5.8	-6.0	2.1e-09	-0.34	0.08	0.66	FALSE
4	GTEx	Adipose Subcutaneous	DESI1	0.08	0.05	lasso	6	0.04	3.3e-04	5.6	-5.6	1.8e-08	-0.52	0.02	0.94	FALSE
5	GTEx	Artery Aorta	POLR3H	0.13	0.04	lasso	5	0.04	1.9e-03	5.8	-5.6	2.1e-08	-0.26	0.00	0.97	FALSE
6	GTEx	Artery Tibial	DESI1	0.22	0.04	lasso	3	0.05	1.6e-04	5.6	-5.5	3.5e-08	-0.40	0.01	0.98	FALSE
7	GTEx	Breast Mammary Tissue	DESI1	0.29	0.05	enet	18	0.11	3.1e-06	5.0	-6.6	5.1e-11	-0.70	0.03	0.97	TRUE
8	GTEx	Breast Mammary Tissue (Male)	CCDC134	0.08	-0.01	enet	1	0.00	3.4e-01	5.8	-5.8	6.8e-09	-0.27	0.03	0.12	FALSE
9	GTEx	Breast Mammary Tissue (Female)	DESI1	0.14	0.07	lasso	4	0.11	4.2e-04	4.0	-6.5	9.5e-11	-0.68	0.03	0.66	FALSE
10	GTEx	Lung	CCDC134	0.14	0.08	lasso	6	0.08	1.4e-06	5.6	-5.4	7.9e-08	-0.44	0.13	0.87	FALSE
11	GTEx	Lung	DESI1	0.12	0.02	lasso	4	0.02	6.6e-03	5.6	-5.7	1.1e-08	-0.47	0.02	0.96	FALSE
12	GTEx	Muscle Skeletal	ACO2	0.07	0.02	lasso	4	0.02	6.9e-03	5.7	5.6	2.6e-08	0.25	0.01	0.97	FALSE
13	GTEx	Nerve Tibial	DESI1	0.31	0.08	enet	40	0.12	1.3e-08	4.0	-5.7	9.1e-09	-0.68	0.10	0.90	FALSE
14	GTEx	Pancreas	DESI1	0.16	0.11	enet	6	0.07	6.8e-04	5.0	-5.6	1.7e-08	-0.46	0.05	0.88	FALSE
15	GTEx	Spleen	CCDC134	0.23	0.00	enet	14	0.09	2.7e-03	4.0	-5.8	8.5e-09	-0.57	0.05	0.32	FALSE
16	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	-4.2	-5.2	2.0e-07	-0.27	0.46	0.45	FALSE
17	GTEx	Uterus	NAGA	0.19	0.07	enet	8	0.06	2.6e-02	2.7	-5.6	2.1e-08	-0.80	0.03	0.62	FALSE
18	GTEx	Whole Blood	DESI1	0.09	0.08	lasso	3	0.07	4.3e-07	5.6	-5.5	3.0e-08	-0.41	0.01	0.99	FALSE
19	GTEx	Whole Blood	CYP2D8P1	0.05	0.00	enet	14	0.01	5.8e-02	3.9	5.3	1.5e-07	0.25	0.20	0.10	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEI1	0.01	0.01	blup	62	0.01	1.1e-02	-4.0	-5.6	1.8e-08	-0.30	0.06	0.61	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC134	0.13	0.07	blup	45	0.10	2.7e-06	-4.0	-5.7	1.6e-08	-0.44	0.01	0.98	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	MEI1	0.05	0.00	blup	64	0.03	1.1e-02	-4.0	-6.1	1.1e-09	-0.35	0.01	0.24	FALSE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	RRP7B	0.16	-0.01	blup	38	0.06	7.3e-03	4.8	5.5	3.7e-08	-0.09	0.00	0.34	TRUE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEI1	0.03	0.01	blup	64	0.02	3.8e-03	-4.3	-5.4	8.6e-08	-0.32	0.03	0.60	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	5.7	-5.4	8.0e-08	-0.21	0.02	0.60	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	-4.4	-5.5	3.2e-08	-0.19	0.01	0.61	FALSE
27	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMM1	0.02	0.01	blup	19	0.02	4.0e-03	-4.2	5.1	3.0e-07	0.25	0.02	0.66	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	-4.3	-5.4	5.3e-08	-0.21	0.02	0.27	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	-3.9	5.4	5.5e-08	0.23	0.02	0.66	FALSE