Hub : Genes

SEL1L3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1920	0.0360	1.4e-10	0.026	0.085	0.080	0.077	0.051	3.5e-04	1.5e-10	5.3e-10	1.1e-09	8.1e-07
2	GTEx	Brain Cerebellum	0.4920	0.1140	1.6e-03	0.224	NA	0.066	NA	0.205	3.1e-07	NA	5.2e-03	NA	1.0e-06
3	GTEx	Liver	0.3670	0.1190	4.7e-03	-0.009	NA	0.001	NA	-0.010	7.4e-01	NA	3.0e-01	NA	7.8e-01
4	GTEx	Nerve Tibial	0.2690	0.0553	8.1e-07	0.178	NA	0.195	NA	0.183	1.3e-12	NA	8.1e-14	NA	5.3e-13
5	METSIM	Adipose	0.0804	0.0264	6.2e-04	0.034	0.036	0.035	0.039	0.037	6.4e-06	3.2e-06	4.4e-06	1.5e-06	2.4e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.2234	0.0383	5.1e-12	0.065	0.103	0.116	0.102	0.101	8.1e-09	3.3e-13	1.1e-14	4.8e-13	5.9e-13
7	YFS	Blood	0.1214	0.0231	1.5e-14	0.050	0.074	0.077	0.091	0.061	5.3e-16	4.3e-23	5.5e-24	4.5e-28	2.3e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.2	0.2	1.0	-0.5	-1.1	-0.6	0.3	-0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	0.1	1.4	-0.3	-1.2	-1.7	0.4	-0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	-0.5	-1.2	-1.1	0.1	-0.3	-0.8	0.3
Depression (Nagel 2018)	0.3	0.4	1.5	0.4	0.0	1.0	0.2	0.2	-0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.8	-2.2	2.2	-1.6	-0.1	-0.2	-0.1	0.0
Neuroticism (Nagel 2018)	0.5	1.3	3.5	-1.6	-0.9	-1.2	0.6	0.0	-1.9	-0.3
Schizophrenia (2018)	0.3	0.7	2.6	-0.2	1.0	-0.6	-0.7	-1.6	0.2	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.2	1.1	0.4	0.7	-1.2	0.6	0.2
Worry (Nagel 2018)	0.4	0.9	3.8	-1.2	0.2	-0.5	0.5	0.4	-2.0	-0.5
Alzheimer’s Disease (in mother)	0.8	0.9	3.6	0.4	-0.4	0.4	-0.7	1.3	-0.5	1.9
Alzheimer’s Disease (in father)	1.2	1.3	3.4	-0.5	-0.4	-0.7	0.7	1.8	-1.1	1.7
Alzheimer’s Disease (including proxy)	1.3	1.9	5.8	-0.4	-0.6	-0.0	-0.3	2.4	-1.4	2.1
Crohns Disease (2017)	0.2	0.4	1.3	-1.0	-1.1	-0.5	-0.1	0.5	0.2	0.4
Irritable Bowel Disease (IBD)	0.4	0.9	2.8	0.1	-1.7	0.1	1.6	0.1	1.0	0.6
Ulcerative Colitis (UC)	0.9	1.6	7.7	1.1	-0.8	0.4	2.8	0.1	1.2	0.2
Major Depression (MDD)	0.5	0.6	1.6	0.2	1.3	-0.7	1.1	-0.6	0.3	-0.3
Reaction Time	0.4	0.8	1.9	1.0	-1.0	-0.5	1.0	1.4	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	7.3	-2.7	1.8	-1.1	-0.3	-1.0	-0.5	0.9
Breast Cancer	0.6	1.6	3.3	-1.8	0.6	-1.7	1.3	-0.7	-1.4	-0.6
Ovarian Cancer	0.2	0.2	0.9	0.3	-0.2	-0.2	0.9	0.6	0.3	0.2
Prostate Cancer	0.2	0.3	0.7	0.5	-0.5	-0.2	-0.1	0.6	-0.5	-0.8
Age at First Birth	0.5	0.7	2.1	0.7	-1.1	0.2	1.4	0.2	1.1	-0.4
Bipolar Disorder (2011)	0.7	0.7	1.7	1.3	-0.4	-0.2	-0.3	0.7	1.0	1.1
Body Mass Index (BMI) (2010)	0.5	0.7	1.8	-0.4	0.8	0.9	-1.3	0.6	-0.6	0.9
Coronary Artery Disease (CAD)	0.4	0.5	1.3	0.7	-0.6	0.5	-1.1	-0.0	1.1	0.4
Crohns Disease (2012)	0.4	0.6	2.3	0.5	-0.9	0.7	-1.5	-0.3	-0.1	-0.2
Mean Putamen Volume	0.5	0.5	1.6	0.8	1.3	-1.1	-0.0	0.2	-0.0	-0.4
Fasting Glucose	0.8	1.0	2.3	0.0	-0.5	0.3	1.5	1.4	0.6	1.4
HbA1C	0.6	0.6	2.5	1.0	-0.1	-0.1	0.8	1.6	0.3	-0.3
HDL Cholesterol	0.7	1.2	3.5	1.6	0.4	-1.0	-0.5	-1.9	-0.4	-0.6
LDL Cholesterol	0.5	0.8	2.2	0.1	0.5	0.4	-0.5	1.5	0.9	1.3
Lupus	0.7	1.0	2.0	-0.6	0.0	1.4	-0.8	-1.3	-1.1	-1.0
Neuroticism (2016)	0.4	0.6	2.1	0.4	1.4	-0.2	-0.3	0.3	-0.9	-0.9
Primary Biliary Cirrhosis	3.2	4.5	10.4	3.2	-1.2	1.0	1.5	1.4	3.2	2.1
Rheumatoid Arthritis	0.3	0.4	1.2	0.0	-1.1	0.9	0.1	0.7	-0.5	-0.5
Schizophrenia (2014)	0.4	0.8	2.7	0.4	1.7	0.0	-0.5	-1.2	1.0	-0.1
Triglycerides	1.1	1.8	5.8	-0.9	0.8	2.4	-0.5	2.0	0.7	0.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.5	0.3	-1.9	-0.8	-1.8	-1.1	0.2	0.2
Ulcerative Colitis	0.8	1.2	4.0	1.1	0.3	1.3	2.0	0.2	1.0	0.5
Blood Eosinophil Count	0.4	2.9	9.4	-3.1	0.8	0.1	-0.7	1.5	-2.6	0.9
Blood Platelet Count	0.2	2.1	4.1	-0.2	-0.3	1.1	-2.0	-1.5	-1.8	-1.9
Blood Red Count	0.1	1.1	3.7	-0.0	-0.0	1.1	-1.9	-0.6	-1.2	-0.9
Blood White Count	0.2	1.3	4.6	-0.5	-2.1	-0.7	-1.2	-0.8	-1.1	-0.7
Heel T-Score	0.6	4.6	18.0	3.0	-0.4	-1.3	1.9	0.3	4.2	-0.3
BMI	0.4	2.4	5.1	-0.4	-2.2	-0.9	-1.9	-1.1	-2.0	-1.4
Height	0.1	2.6	9.2	-3.0	0.7	-0.0	-0.4	-1.3	-2.5	-0.6
Waist Hip Ratio (WHR)	2.8	12.7	41.2	0.5	-0.6	-0.4	6.4	6.1	3.1	0.9
Systolic Blood Pressure	0.6	3.1	5.7	2.1	-0.9	-0.7	2.4	1.9	2.2	1.2
Smoking Status	0.5	1.3	3.8	2.0	0.7	-1.5	1.3	0.3	0.6	0.2
Allergy or Eczema	0.5	1.4	4.0	1.0	0.8	0.6	2.0	1.6	-0.7	-0.9
Cardiovascular Disease	0.3	1.1	4.0	-0.6	-2.0	0.7	-0.9	1.1	-0.3	1.0
Hypothyroidism (self reported)	1.0	2.2	7.1	-2.5	-0.5	0.3	-0.1	2.7	-1.3	0.3
Respiratory disease	0.2	0.5	1.3	-1.0	-1.1	0.4	1.0	-0.2	-0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	-0.2	0.4	1.2	1.0	1.4	0.9	-0.1
Lung FEV1/FVC ratio	0.6	2.9	5.0	-1.5	-2.2	-1.8	-2.2	-0.5	-2.2	-0.4
Lung FVC	0.5	2.6	14.3	0.2	0.2	3.8	1.7	-0.7	0.2	0.6
Neuroticism	0.6	1.5	3.0	-1.5	-1.2	-1.7	1.1	0.5	-1.4	-0.0
Chronotype (morning person)	1.0	2.2	5.8	-1.3	1.5	0.4	-0.7	-0.7	-2.2	-2.4
Hair Pigment	0.0	0.9	2.5	-1.1	0.4	-0.0	-1.4	-0.4	-1.6	-0.6
Tanning	0.2	2.2	3.2	-1.8	-1.4	-1.6	-1.0	-1.6	-1.4	-1.6
Hand grip strength (left)	0.4	1.0	2.3	-1.0	1.5	-1.1	1.3	1.1	-0.1	-0.1
Number of treatments/medications taken	0.4	0.8	2.4	0.7	0.2	-0.7	-1.2	-0.4	-1.6	-0.7
Average weekly spirits intake	2.7	3.4	5.2	-2.1	0.5	-2.1	-1.8	-1.6	-2.3	-1.8
Sensitivity / hurt feelings	0.1	0.1	0.3	-0.5	0.2	-0.5	0.2	-0.2	-0.5	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.1	1.2	-1.3	0.7	-0.2	-0.4	0.5	-1.5
Hearing difficulty/problems: Yes	0.6	0.9	4.1	-0.0	-1.3	-0.1	-0.4	0.6	-2.0	0.1
Relative age of first facial hair	0.8	1.7	4.6	0.4	0.8	-1.5	1.6	2.1	1.0	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	0.6	-0.5	0.6	-0.5	-0.1	-0.5	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.8	1.6	-1.4	0.4	1.1	1.7	0.8	-1.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.2	-0.3	-1.1	0.9	-0.3	-0.6	0.6	-0.6
Systolic blood pressure, automated reading	1.0	3.0	4.9	1.9	-1.4	-1.7	1.7	2.2	0.8	2.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-1.0	0.6	0.7	0.1	0.8	-0.4	-0.7
Angina	0.4	0.5	1.6	0.6	-1.3	0.1	-0.7	0.5	-0.7	-0.3
Medication for hormone replacement therapy	1.2	1.3	5.2	1.0	-0.5	-0.4	-0.4	1.4	2.3	0.8
Vitamin and mineral supplements	0.8	1.1	2.4	-1.5	1.1	-0.9	1.4	0.5	0.1	-1.1
Supplements: Zinc	0.7	0.7	2.2	1.1	0.2	0.5	-1.0	-1.5	-0.5	0.1
Medication: Co-codamol	0.4	0.4	1.5	0.6	-0.4	1.2	-0.5	-0.1	-0.9	0.1
Medication: Metformin	0.3	0.4	1.4	0.3	0.2	0.6	0.6	0.2	1.2	-0.4
Diabetes (father)	0.8	1.0	2.4	1.5	1.0	0.1	0.9	0.7	1.6	-0.0
Diabetes (mother)	1.4	1.8	4.0	0.6	0.3	1.0	1.0	1.8	2.0	1.6
Severe depression (siblings)	1.7	1.9	6.5	0.4	-1.0	-0.5	0.6	0.8	-2.5	-2.0
Pack years adult smoking proportion	1.7	2.5	5.9	-1.1	-0.3	1.2	-2.4	-0.8	-2.3	-1.7
Impedance of leg (right)	0.4	2.0	6.7	-0.1	1.8	0.2	2.6	1.1	1.3	1.0
Leg fat-free mass (left)	1.0	5.5	10.0	-2.2	-1.6	-1.6	-3.1	-2.3	-3.2	-1.8
Trunk fat percentage	0.8	3.4	9.2	-0.5	-1.1	-3.0	-1.2	-2.2	-2.0	-1.6
Hand grip strength (right)	0.4	1.1	2.5	-0.7	1.6	-1.2	0.9	1.1	-0.1	1.1
Townsend deprivation index at recruitment	1.7	2.4	8.9	-0.6	1.1	0.1	-2.4	-3.0	0.5	-0.7
Current tobacco smoking	0.8	1.3	3.9	2.0	1.3	0.8	0.6	0.6	0.1	-1.3
Average weekly fortified wine intake	0.3	0.4	1.9	0.2	0.3	-0.4	0.1	0.1	-1.4	-0.7
Maternal smoking around birth	0.8	1.2	5.5	0.4	-2.3	0.1	-0.3	-1.2	0.2	-1.1
Fed-up feelings	0.3	0.6	2.1	-0.1	-0.9	-0.0	-0.4	-1.4	-0.8	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	3.1	-0.0	-0.0	-0.3	-0.0	-0.8	-0.3	-1.8
Relative age voice broke	0.4	0.7	2.1	0.4	1.1	-0.2	0.5	1.5	-0.0	-1.0
Taking other prescription medications	0.3	0.4	2.0	-0.1	-0.7	0.1	0.3	-0.3	-1.4	-0.2
Age when periods started (menarche)	0.1	0.2	0.6	0.4	0.2	-0.1	0.6	0.2	-0.7	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.0	1.7	-1.0	0.5	0.0	-0.5	1.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	1.0	-1.0	-0.1	0.6	-0.6	0.8	-0.1
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.9	2.2	-1.3	-0.2	1.1	-0.9	1.6	0.9
Qualifications: CSEs or equivalent	1.0	1.3	3.5	0.0	-1.5	1.0	-1.3	-1.9	-0.8	-0.1
Serious illness, injury or assault to yourself	0.4	0.4	2.1	-0.3	0.3	0.0	-0.2	0.1	-0.9	-1.4
High blood pressure	0.5	1.3	4.2	0.2	-1.6	0.0	0.2	1.4	0.2	2.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.9	1.0	-0.1	0.9	1.2	1.4	-1.2	-0.6
Multivitamins +/- minerals	0.9	1.1	4.7	2.2	-1.1	0.7	-0.8	-0.8	0.4	0.4
Stomach or abdominal pain in last month	1.2	1.5	3.6	-1.1	-0.6	-0.5	-1.9	-1.9	-1.1	-0.8
Supplements: Glucosamine	1.7	2.2	9.0	3.0	-0.3	0.3	1.9	0.6	0.7	1.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	-1.0	-0.9	0.2	-1.3	0.8	-1.2	-1.2
Medication: Atenolol	0.7	0.9	1.8	0.6	-0.5	-1.4	1.2	0.8	1.2	0.6
Medication: Levothyroxine sodium	1.0	1.7	8.3	-2.9	0.3	0.6	-1.2	0.5	-1.4	0.1
Sitting height	0.7	4.8	16.5	-4.1	0.4	-0.1	-1.4	-1.5	-3.1	-1.8
Chronic bronchitis/emphysema (father)	1.5	1.7	6.1	-1.4	-0.3	-0.5	-0.7	-1.4	-1.1	-2.5
High blood pressure (mother)	1.0	1.4	2.6	1.1	1.4	0.7	1.4	0.7	1.6	1.1
Body mass index (BMI)	0.8	3.4	6.4	-0.1	-2.5	-2.5	-2.2	-1.8	-1.6	-0.9
Impedance of leg (left)	0.5	2.5	8.1	0.2	2.2	0.4	2.9	1.3	1.4	1.1
Leg predicted mass (left)	1.0	5.4	10.0	-2.1	-1.6	-1.6	-3.1	-2.3	-3.2	-1.7
Trunk fat mass	1.0	4.4	8.5	-1.1	-1.4	-2.9	-1.9	-2.3	-2.6	-1.8
Waist circumference	0.6	2.4	6.9	-1.4	-2.6	-1.7	-0.4	0.1	-1.9	-1.0
Number of incorrect matches in round	1.0	1.7	8.4	0.3	1.3	2.9	0.5	0.3	-0.0	-1.0
Past tobacco smoking	0.3	0.5	1.5	-0.8	-0.1	1.2	-0.6	0.4	-0.2	-0.9
Alcohol usually taken with meals	0.9	1.4	4.2	-0.7	-2.0	0.9	1.1	1.7	0.6	-0.0
Nervous feelings	0.2	0.4	1.3	-0.6	-1.1	0.3	0.3	-0.0	-1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.7	1.2	-0.2	-0.5	1.9	0.6	0.0	0.1
Hearing difficulty/problems with background noise	0.5	0.8	3.1	0.3	0.0	0.6	1.8	1.0	0.7	0.6
Hair/balding pattern: Pattern 2	1.6	2.1	6.2	2.0	-0.2	-0.1	1.5	0.4	2.5	1.4
Had menopause	0.2	0.3	0.9	0.1	-0.1	-0.5	0.5	0.2	0.6	1.0
Had other major operations	0.9	1.1	3.0	-1.0	-1.7	1.2	-0.8	-0.3	-0.9	-0.8
Forced vital capacity (FVC)	0.5	2.1	9.6	-1.3	0.6	3.1	-0.7	-0.5	-1.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.8	0.4	0.3	0.9	0.0	0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	10.0	2.4	0.6	-0.9	3.2	1.9	2.6	1.5
Qualifications: None of the above	0.1	0.3	0.7	-0.2	0.4	0.6	-0.8	0.0	0.2	-0.8
Financial difficulties in last 2 years	0.2	0.3	0.7	0.8	-0.2	-0.0	-0.6	0.6	-0.3	-0.7
Mouth/teeth dental problems	0.8	1.2	3.9	0.2	0.7	0.9	-1.0	-2.0	-0.7	-1.3
Heart attack	0.5	0.6	1.2	1.0	0.9	0.9	-0.3	1.1	-0.0	0.3
Allergy	0.3	0.6	2.9	-0.4	-0.1	-0.6	-0.3	-0.2	1.7	0.9
Pain all over the body in last month	1.2	1.3	2.9	1.5	-1.7	0.8	0.6	0.2	1.1	1.2
Diabetes (self-reported)	1.3	2.0	3.8	1.3	1.4	1.1	1.5	1.6	2.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-0.9	0.4	0.3	0.7	1.1	-0.8	-0.6
Medication: Ramipril	0.2	0.3	0.7	-0.6	-0.8	0.3	-0.5	-0.3	0.1	-0.8
Medication: Simvastatin	1.5	2.2	5.4	1.3	0.7	0.2	1.0	2.3	1.2	2.3
Fluid intelligence score	0.5	1.0	3.2	-1.0	0.5	-0.4	0.6	0.9	1.2	1.8
Illnesses of siblings	0.8	1.2	2.2	1.2	0.6	1.2	-1.1	-0.7	-1.0	-1.5
Neuroticism score	0.2	0.5	1.1	-0.2	-0.7	-0.7	1.0	0.6	-1.0	0.1
Weight	1.0	5.0	8.0	-2.0	-2.0	-2.4	-2.6	-2.2	-2.8	-1.5
Impedance of arm (right)	0.3	1.3	5.1	0.7	1.6	-0.4	2.3	0.2	0.8	-0.7
Arm fat percentage (right)	0.9	3.6	8.9	-0.1	-2.0	-3.0	-1.7	-2.1	-1.7	-1.5
Trunk fat-free mass	0.5	2.9	6.5	-2.5	-1.7	-0.2	-2.2	-0.9	-2.2	-0.5
Hip circumference	1.6	6.7	11.9	-1.9	-2.4	-1.5	-3.5	-3.0	-3.5	-1.5
Time employed in main current job	0.8	1.0	5.2	0.1	0.9	-2.3	0.5	-0.3	0.6	-0.4
Alcohol intake versus 10 years previously	0.2	0.2	0.9	0.2	-0.9	0.3	0.0	-0.6	0.5	0.2
Father’s age at death	0.3	0.4	0.9	0.9	0.1	0.6	1.0	0.3	0.3	0.8
Worrier / anxious feelings	0.3	0.5	1.3	-0.7	0.4	-0.6	1.1	0.8	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.4	-0.2	-0.0	-0.1	-1.8	-0.7	-1.8	-1.3
Falls in the last year	0.2	0.3	1.2	1.1	-0.0	-0.2	-0.5	0.3	-0.3	-0.7
Hair/balding pattern: Pattern 3	1.6	2.4	6.2	-2.1	1.4	1.1	-1.0	-0.8	-2.5	-1.2
Number of live births	0.5	0.7	2.6	0.1	-1.1	1.6	-0.3	1.0	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.2	-1.3	0.3	2.3	-0.8	-1.1	-1.6	-0.5
Pulse rate	2.7	4.6	12.6	-1.3	-1.7	-0.0	-3.5	-2.7	-2.1	-2.0
Happiness	0.4	0.5	1.4	-1.2	0.2	0.3	-0.2	0.1	-1.2	-0.9
Noisy workplace	1.0	1.2	3.0	0.6	0.8	-0.7	1.1	1.7	1.7	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.0	-0.3	1.5	-0.5	1.7	0.9	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	4.8	1.9	-0.9	1.0	2.2	2.1	2.1	0.6
Mouth/teeth dental problems: Dentures	0.9	1.5	5.0	1.1	0.7	-0.6	1.4	2.2	1.2	0.2
Asthma	0.2	0.3	1.1	-0.5	-1.0	-0.4	0.6	-0.6	-0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	9.0	-0.5	1.0	0.9	-3.0	-1.9	-0.7	-1.5
Medication: Cholesterol lowering	0.5	0.8	3.1	0.6	1.2	0.0	0.3	1.8	-0.2	0.7
Depression (self-reported)	0.9	1.1	3.1	0.9	0.1	-1.8	-0.5	-1.1	0.2	-1.4
Medication: Lansoprazole	0.9	1.1	2.2	1.4	-0.0	-0.3	1.4	1.5	0.6	-0.8
Prospective memory result	0.3	0.3	1.0	1.0	-0.4	-0.9	-0.0	0.4	-0.0	-0.2
Lung cancer (father)	0.3	0.4	1.8	-0.6	-1.3	0.3	0.4	0.2	0.1	0.3
Illnesses of mother	0.9	1.1	2.9	-0.8	0.1	1.3	-1.0	-1.7	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.7	-1.1	0.3	2.4	-0.6	-0.5	-1.4	-0.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-0.5	-0.6	0.7	-0.3	0.1	-1.3	-1.2
Impedance of arm (left)	0.3	1.4	5.7	0.8	1.5	0.3	2.4	0.1	0.8	-0.6
Arm fat mass (right)	0.9	3.6	7.4	-0.7	-2.2	-2.7	-2.0	-1.9	-2.0	-1.0
Trunk predicted mass	0.5	2.9	6.3	-2.5	-1.7	-0.2	-2.2	-0.9	-2.2	-0.5
Standing height	0.4	3.9	14.2	-3.8	0.5	0.1	-0.9	-1.0	-2.8	-1.7
Length of working week for main job	0.9	1.0	3.0	0.7	-0.5	0.4	-1.7	-0.0	-1.6	-0.7
Exposure to tobacco smoke at home	0.9	1.0	3.9	-0.3	-0.0	2.0	-1.2	-1.1	-0.4	-0.1
Breastfed as a baby	0.2	0.2	1.0	0.3	0.5	-0.1	-0.4	-0.3	1.0	0.2
Tense / ‘highly strung’	0.5	0.8	2.4	0.1	-0.0	0.3	1.6	0.7	-1.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.2	-0.0	-0.1	0.6	-0.0	-0.6	0.6
Hair/balding pattern: Pattern 4	0.1	0.3	1.6	-0.5	0.3	-0.2	1.2	0.1	0.1	-0.5
Birth weight of first child	0.5	1.0	4.6	-0.2	-0.3	-0.1	-0.8	-2.1	-1.0	-0.7
Peak expiratory flow (PEF)	0.2	0.4	2.0	-0.5	1.4	-0.1	0.3	0.3	0.1	0.7
Pulse wave reflection index	1.5	1.8	4.0	1.6	0.7	-0.1	1.7	2.0	1.6	0.7
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.4	0.5	-0.1	-0.2	0.2	-0.8	0.2
Loud music exposure frequency	1.0	1.1	2.4	1.5	-0.3	-0.9	0.7	-0.1	1.4	-1.3
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	7.9	1.8	-0.2	-0.8	2.8	1.1	1.3	1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	-0.9	0.5	-1.4	1.5	0.5	0.4	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.9	-0.0	0.6	-0.4	-0.6	0.2	-0.2	-1.0
Medication: Paracetamol	1.3	2.1	8.3	2.9	0.7	1.2	0.5	0.0	1.2	1.7
Headache pain in last month	0.1	0.2	0.6	-0.2	-0.2	0.3	-0.8	0.2	0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-0.3	-0.8	0.8	0.6	-1.0	0.8	-0.7
Glaucoma (self-reported)	0.8	1.0	4.0	0.6	1.0	-0.0	0.6	2.0	0.6	0.7
Gout (self-reported)	0.9	1.2	2.3	-0.2	-1.1	-1.1	-1.3	-1.5	-0.7	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.6	-1.7	0.5	0.3	-0.0	1.9	-0.8	0.1
Medication: Amlodipine	1.4	2.0	7.8	-0.7	-2.8	0.4	-0.9	-0.7	-1.9	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.3	-0.1	-0.6	-0.0	0.8	-0.1	0.5	1.5
Birth weight	0.2	0.5	1.4	0.1	-1.2	-0.0	-0.1	0.7	-0.7	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	1.2	-0.1	-0.7	-0.9	-0.5	-0.2	0.8
High blood pressure (siblings)	0.4	0.5	1.1	0.0	0.2	-1.0	0.9	0.5	0.7	1.0
Forced vital capacity (FVC), Best measure	0.5	1.9	9.1	-1.1	1.0	3.0	-0.4	-0.6	-1.3	0.2
Body fat percentage	0.9	3.4	8.9	-0.6	-1.4	-3.0	-1.4	-2.1	-2.0	-1.4
Leg fat percentage (right)	0.7	2.7	6.9	-0.7	-2.0	-2.6	-1.4	-1.3	-1.6	-1.1
Arm fat-free mass (right)	0.6	3.3	7.1	-2.4	-1.0	-0.7	-2.7	-1.2	-2.6	-0.6
Exposure to tobacco smoke outside home	1.1	1.5	6.2	-0.1	-1.4	-0.2	-2.5	-1.4	-0.4	-0.5
Comparative body size at age 10	0.1	0.4	1.0	1.0	-0.2	-0.7	-0.0	-0.3	0.5	0.9
Number of full brothers	0.6	0.7	2.1	-0.7	0.2	0.0	-0.6	-0.3	-1.4	-1.4
Worry too long after embarrassment	0.9	1.6	3.2	-1.1	0.5	-1.8	1.5	0.9	0.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.3	-0.2	1.0	-0.7	0.2	-1.8	0.2	0.1
Wheeze or whistling in the chest in last year	0.4	0.8	2.3	0.6	-1.5	0.0	0.3	-1.1	-0.4	-1.1
Number of children fathered	0.9	1.0	3.1	1.1	-0.5	1.4	0.8	1.8	-0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.6	1.0	-0.6	0.9	0.6	0.0	1.4
Age at first live birth	1.5	2.7	5.6	1.4	1.4	2.4	1.9	1.2	1.7	1.3
Pulse wave peak to peak time	0.2	0.3	0.8	0.0	0.5	-0.5	0.1	-0.1	0.8	0.9
Health satisfaction	1.0	1.4	3.8	-0.8	-0.5	0.3	-1.6	-0.1	-2.0	-1.5
Shortness of breath walking on level ground	1.0	1.2	4.5	2.1	0.7	-1.3	0.1	0.6	0.2	1.1
Qualifications: College or University degree	0.8	2.6	5.0	0.8	0.9	-0.2	2.1	2.2	1.7	2.1
Eye problems/disorders: None of the above	0.2	0.2	0.7	-0.0	0.3	-0.6	-0.8	-0.5	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.1	0.2	-1.1	-0.2	-0.8	0.2	0.3	0.7
Emphysema/chronic bronchitis	0.7	0.7	2.8	-0.2	-0.3	-0.2	-0.8	-1.1	-1.7	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	3.4	-0.9	-1.8	-0.4	1.1	-0.4	0.9	-0.7
Neck or shoulder pain in last month	0.3	0.5	1.3	-0.8	1.1	-0.4	-0.6	0.8	-0.5	0.2
Medication: Blood pressure	0.2	0.4	1.3	0.6	-0.2	-1.2	-0.5	0.5	-0.2	0.7
Angina (self-reported)	0.4	0.5	1.5	0.5	-1.2	0.0	-0.9	0.4	-0.8	-0.6
Migraine (self-reported)	0.7	0.9	4.3	0.2	-1.1	-0.3	0.8	-0.4	2.1	0.3
Medication: Ibuprofen	1.7	2.0	7.2	-0.1	0.6	1.3	-2.7	-1.5	-0.3	-1.6
Medication: Allopurinol	0.7	0.9	2.3	0.6	-1.5	-1.0	-0.5	0.2	0.6	1.4
Medication: Omeprazole	1.2	1.4	4.0	-0.6	-0.6	-0.9	-1.6	-0.9	-2.0	-1.1
Medication: Seretide 50 evohaler	0.4	0.4	1.2	0.7	1.1	0.9	-0.3	0.1	0.2	0.4
Mean time to correctly identify matches	0.3	0.5	2.5	0.3	-0.4	-0.3	0.6	1.6	-0.2	0.1
Heart disease (mother)	0.3	0.4	1.2	-0.0	0.1	-1.1	-0.4	0.8	-1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	5.3	2.2	2.3	-1.9	0.5	0.6	0.9	0.5
Whole body fat mass	0.9	3.9	7.9	-1.3	-1.5	-2.8	-1.9	-2.2	-2.3	-1.3
Leg fat mass (right)	0.9	3.6	7.5	-1.3	-1.7	-2.7	-1.9	-1.9	-2.2	-1.2
Arm predicted mass (right)	0.6	3.0	6.2	-2.5	-1.1	-0.6	-2.5	-1.2	-2.4	-0.3
Pulse rate, automated reading	0.5	1.6	4.6	-0.4	-1.4	-0.2	-2.1	-1.9	-0.1	-0.7
Alcohol intake frequency.	1.3	3.1	10.7	-1.6	-0.1	0.4	-3.3	-2.6	-1.1	-0.5
Comparative height size at age 10	0.8	4.4	13.1	-3.6	1.4	-2.3	-1.8	-0.7	-2.2	-1.3
Number of full sisters	0.9	1.1	2.5	-0.3	-1.6	-1.4	-1.0	-0.9	-0.9	-0.9
Suffer from ‘nerves’	0.6	1.0	3.9	0.4	-0.7	0.4	2.0	0.0	-1.5	-0.0
Overall health rating	0.7	1.5	4.6	-0.7	-0.7	-0.1	-1.0	0.1	-1.9	-2.2
Chest pain or discomfort	1.0	1.4	5.7	0.9	-2.4	-0.7	0.2	0.7	-0.4	1.3
Had major operations	0.6	0.7	2.9	0.3	-0.6	-0.6	-0.1	1.7	0.2	1.0
Age at last live birth	1.8	2.6	5.2	2.0	2.0	2.3	0.9	0.7	1.7	1.1
Family relationship satisfaction	1.2	1.5	4.6	-0.3	-0.5	1.8	1.1	2.1	-1.0	0.7
Leg pain on walking	1.2	1.5	3.5	-0.1	0.3	0.9	-1.9	-0.3	-1.6	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.9	0.0	-1.6	-0.9	-2.4	-0.5	-1.3	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	0.4	-0.7	1.0	-0.1	0.0	-0.3	1.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	6.5	-2.5	0.5	-0.7	-0.1	-0.4	-2.1	0.1
Medication: Aspirin	0.8	1.1	1.9	-1.4	1.1	0.7	-0.8	1.4	-1.2	0.3
Supplements: Vitamin C	1.3	1.6	3.8	1.7	1.7	1.0	-0.6	1.9	0.1	0.4
Knee pain experienced in last month	1.0	1.6	5.8	-0.3	-0.2	-0.4	-2.4	-0.8	-2.1	-0.2
Hypertension (Self-reported)	0.4	1.1	3.6	1.0	-1.0	0.1	0.0	1.4	0.2	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	9.5	0.8	-3.1	-1.5	1.0	-0.1	-0.8	0.6
Illnesses of father: Heart disease	1.5	2.1	5.0	0.7	-2.1	-1.0	1.3	2.2	0.2	1.5
Illnesses of siblings: Diabetes	1.4	1.7	4.3	-1.1	1.1	-1.4	0.9	2.1	-0.7	1.4
Smoking status: Previous	0.6	0.8	3.6	0.0	-0.4	-1.9	0.2	-1.0	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.3	-0.5	1.2	-0.3	-0.4	-1.1	-0.7	-1.8
Whole body fat-free mass	0.7	3.7	7.1	-2.5	-1.6	-0.7	-2.6	-1.5	-2.7	-0.9
Leg fat-free mass (right)	0.9	4.8	10.0	-2.0	-1.5	-1.3	-3.0	-2.1	-3.2	-1.6
Arm fat percentage (left)	0.8	3.2	7.1	0.2	-2.1	-2.7	-1.6	-2.1	-1.6	-1.4
Average weekly red wine intake	1.3	1.9	6.7	0.6	-0.7	-0.9	2.6	1.8	0.8	1.2
Handedness (chirality/laterality): Left-handed	1.5	1.8	6.8	0.8	1.7	-1.0	0.9	2.6	0.6	0.1
Mood swings	0.4	0.8	3.0	0.1	-0.1	-0.2	-1.7	-1.1	-1.1	0.2
Loneliness, isolation	0.3	0.4	1.5	0.6	-0.9	-1.2	0.2	0.3	-0.1	-0.1
Long-standing illness, disability or infirmity	1.7	2.7	9.5	-0.5	-0.8	0.6	-2.1	-0.6	-3.1	-1.7
Ever had bowel cancer screening	0.4	0.5	1.0	0.3	0.9	1.0	-0.1	0.9	0.4	-0.6
Diabetes diagnosed by doctor	1.1	1.9	4.1	0.8	1.1	1.4	1.6	2.0	1.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	-0.3	-1.3	-1.1	-0.8	-0.9	-0.5	-0.4
Friendships satisfaction	1.0	1.2	2.5	-1.6	-0.2	1.6	0.3	1.5	-0.8	0.7
Qualifications: nursing, teaching	0.8	1.2	5.0	0.9	0.6	0.9	2.2	-0.4	0.9	-0.5
Commuting to job workplace: Walk	1.0	1.1	2.5	-1.0	0.7	1.0	-1.1	-0.5	-0.9	-1.6
Eye problems/disorders: Cataract	0.8	0.9	3.8	0.7	-0.2	-2.0	0.8	-0.1	0.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.5	-1.0	-1.0	0.9	-0.9	0.1	-1.6	0.5
Medication for cholesterol	0.8	1.2	3.1	-0.5	0.7	-1.2	-0.8	-1.8	-1.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.9	-0.0	-0.5	0.0	-1.8	-2.0	-0.8	-0.4
Back pain experienced in last month	0.9	1.3	4.8	-0.2	-0.1	-0.8	-2.2	-0.7	-1.2	-1.2
Mineral and other dietary supplements	0.4	0.5	1.3	-1.1	0.5	-1.0	-0.8	0.6	0.1	-0.4
Breast cancer (self-reported)	0.2	0.2	1.2	-1.1	-0.4	-0.2	0.2	0.1	0.5	-0.0
Asthma (self-reported)	0.2	0.4	1.8	-0.3	-1.3	0.1	0.6	-0.4	-0.3	-0.1
Osteoporosis (self-reported)	1.0	1.3	2.8	-0.9	0.9	-0.6	-1.1	-1.7	-1.5	-0.8
Osteoarthritis (self-reported)	0.3	0.4	1.4	0.4	-0.7	0.1	-0.3	-0.7	-0.4	1.2
Medication: Aspirin	0.7	0.9	2.7	-1.2	0.3	0.7	-0.6	1.7	-1.1	0.3
Medication: Gliclazide	0.5	0.6	3.4	0.8	0.3	0.1	0.2	-0.2	1.9	-0.0
Illnesses of father: None of the above (group 1)	1.0	1.3	2.9	-1.2	1.1	1.0	-0.9	-1.7	-0.6	-1.0
Smoking status: Current	0.7	1.1	4.0	2.0	1.2	0.5	0.8	0.5	0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.0	-0.7	1.0	0.9	-0.3	-0.0	0.4
Whole body water mass	0.7	4.2	7.8	-2.6	-1.6	-0.8	-2.8	-1.6	-2.8	-1.0
Leg predicted mass (right)	1.0	5.1	11.0	-2.1	-1.6	-1.3	-3.1	-2.1	-3.3	-1.5
Arm fat mass (left)	0.8	3.4	6.2	-0.5	-2.1	-2.5	-2.0	-2.0	-1.9	-1.2
Number of self-reported non-cancer illnesses	0.2	0.3	0.5	-0.7	-0.7	-0.1	-0.6	0.6	-0.6	0.5
Average weekly champagne plus white wine intake	2.0	2.7	6.7	0.5	-1.1	0.2	2.2	2.6	0.6	2.4
Miserableness	0.4	0.7	1.6	-0.3	-1.0	-0.4	-0.8	-1.1	-1.3	-0.3
Guilty feelings	0.9	1.3	6.2	-0.2	0.5	0.6	2.5	0.9	1.1	0.5
Wears glasses or contact lenses	0.4	0.5	2.0	-0.1	-0.5	-0.0	1.4	0.9	0.6	-0.3
Ever taken oral contraceptive pill	0.9	1.0	4.4	-0.4	2.1	0.9	0.8	0.3	-0.2	-0.9
Hearing aid user	0.7	0.8	3.8	0.3	-1.9	-0.3	-0.6	0.4	-0.7	0.6
Mother’s age at death	1.3	1.6	8.7	0.7	-0.7	3.0	-0.4	-0.2	1.2	0.3
Financial situation satisfaction	0.5	0.6	1.9	-0.8	-1.2	1.4	0.4	-0.2	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	0.2	1.0	-0.6	0.4	1.0	1.7	1.4
Commuting to job workplace: Public transport	1.1	1.3	7.7	-1.1	2.8	-0.2	0.5	0.1	0.2	-0.3
Eye problems/disorders: Glaucoma	1.6	1.9	6.1	1.0	0.1	-0.3	1.6	2.5	1.0	1.7
Medication: Blood pressure	1.6	3.0	5.7	0.7	-1.1	2.2	2.2	2.4	1.6	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.1	-0.4	-1.0	-0.9	-1.0	-0.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.6	1.3	-0.4	1.2	1.1	-0.5	0.7	0.6
High cholesterol (Self-reported)	0.3	0.5	1.8	-0.3	-0.5	0.4	1.2	1.3	0.2	0.1
Medication: Bendroflumethiazide	0.5	0.7	2.0	1.4	-1.3	0.5	1.0	0.1	-0.1	0.2
Medication: Paracetamol	1.2	1.8	7.8	2.8	0.2	1.2	0.3	0.8	0.8	1.4
Medication: Lisinopril	1.8	2.3	10.5	0.7	1.2	0.4	1.6	3.2	1.1	0.4
Medication: Atorvastatin	0.6	0.8	1.2	-0.9	0.4	-0.9	1.0	0.8	-0.9	-1.1
Illnesses of father: High blood pressure	1.8	2.3	4.9	1.5	0.6	-1.5	1.9	2.2	1.7	-0.2
Alcohol drinker status: Never	0.4	0.5	1.9	-1.4	0.2	1.1	-0.2	0.0	-0.1	0.4
Ever smoked	0.2	0.3	1.2	0.8	0.2	-0.1	0.6	-0.0	0.0	1.1
Basal metabolic rate	0.8	4.5	8.2	-2.5	-1.8	-1.2	-2.8	-1.8	-2.9	-1.1
Leg fat percentage (left)	0.7	2.4	6.2	-0.6	-2.0	-2.5	-1.4	-1.2	-1.5	-0.9
Arm fat-free mass (left)	0.8	4.1	9.0	-2.8	-1.4	-0.9	-3.0	-1.7	-2.5	-0.5
Number of operations (self-reported)	0.2	0.3	0.7	0.1	-0.5	0.9	-0.7	0.2	-0.5	-0.8
Average weekly beer plus cider intake	0.7	1.0	2.9	1.7	0.6	0.4	-0.9	-1.4	0.5	0.9
Irritability	2.5	4.3	11.8	-2.6	-1.9	-0.1	-2.0	-1.5	-3.4	-1.4
Risk taking	0.8	1.2	3.3	1.8	0.3	1.8	-0.5	0.3	1.0	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	2.1	-0.6	-0.4	0.3	1.5	0.1	-0.1	-0.4
Fractured/broken bones in last 5 years	0.5	0.6	2.6	0.6	-0.8	0.2	0.5	0.6	-0.4	-1.6
Age started oral contraceptive pill	1.0	1.2	4.1	0.1	2.0	1.4	0.7	1.1	0.6	0.4
Diastolic blood pressure, automated reading	0.4	1.1	4.3	0.9	-2.1	-0.9	0.6	0.1	1.1	0.6
Ever depressed for a whole week	2.1	2.6	7.1	0.9	2.5	-0.5	2.7	0.2	1.7	0.9
Unable to work because of sickness or disability	0.7	0.9	2.1	0.4	-0.8	-0.8	-1.5	-1.2	-0.9	-0.9
Commuting to job workplace: Cycle	0.8	1.0	2.9	-0.2	-1.5	1.2	-0.2	-1.7	-0.3	0.3
Myopia	0.2	0.2	1.4	-1.2	0.1	-0.5	0.1	-0.1	0.0	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.7	-0.2	1.4	-0.2	0.3	-1.6	0.1	-1.9
Cholesterol lowering medication	0.8	1.2	2.1	-0.2	-0.5	1.4	1.4	1.3	1.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	0.3	0.7	-1.7	-1.0	-0.7	-1.5	-0.6
Pain experienced in last month	0.8	1.3	6.2	0.8	0.2	-1.1	2.5	0.2	0.9	0.5
Supplements: Calcium	0.6	0.7	2.3	1.5	1.0	0.6	-0.2	-1.0	-0.5	-0.1
Basal cell carcinoma (self-reported)	1.9	2.2	4.6	-0.9	0.1	0.0	-2.1	-1.5	-2.0	-1.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	0.9	0.8	0.9	-0.2	1.0	0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-0.2	0.7	-0.6	-0.4	0.1	-0.4	-1.1
Heart disease (siblings)	0.6	0.8	3.9	-0.3	-0.6	-2.0	0.2	0.2	0.0	1.0
Alcohol drinker status: Previous	0.4	0.5	1.5	-0.2	-0.7	-1.2	-0.0	0.2	-1.2	-0.0
Pack years of smoking	1.2	1.7	4.5	-0.9	-0.2	0.9	-2.1	-0.4	-1.9	-1.5
Impedance of whole body	0.4	2.1	6.3	0.7	2.4	0.5	2.5	0.4	1.2	-0.1
Leg fat mass (left)	0.9	3.7	7.5	-1.1	-1.8	-2.7	-1.9	-2.0	-2.2	-1.2
Arm predicted mass (left)	0.7	3.6	7.6	-2.6	-1.4	-0.8	-2.8	-1.2	-2.5	-0.5