Hub : Genes

STIM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.2470	0.0910	6.8e-03	0.069	NA	0.043	NA	0.081	8.3e-03	NA	3.1e-02	NA	4.6e-03
2	GTEx	Whole Blood	0.0920	0.0370	4.3e-03	0.034	NA	0.044	NA	0.033	4.2e-04	NA	6.1e-05	NA	5.0e-04
3	METSIM	Adipose	0.0488	0.0194	2.2e-03	0.005	0.010	0.000	0.008	-0.002	4.6e-02	1.1e-02	2.7e-01	1.8e-02	9.1e-01
4	NTR	Blood	0.0544	0.0120	1.8e-13	0.047	0.041	0.054	0.048	0.055	6.4e-15	2.8e-13	8.0e-17	3.2e-15	3.0e-17
5	ROSMAP	Brain Pre-frontal Cortex	0.0840	0.0214	8.7e-09	0.082	0.076	0.078	0.075	0.079	9.6e-11	5.3e-10	3.1e-10	7.5e-10	2.3e-10
6	YFS	Blood	0.2475	0.0318	0.0e+00	0.095	0.200	0.199	0.191	0.186	2.1e-29	3.0e-63	4.1e-63	2.2e-60	1.2e-58
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0285	0.0165	7.1e-03	0.005	0.009	0.002	NA	0.002	7.7e-02	2.6e-02	1.5e-01	NA	1.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	0.9	1.7	0.2	1.0	1.3	1.1	1.3	-0.6	0.5
Bipolar Disorder or Schizophrenia	0.9	2.1	5.6	0.2	2.4	0.4	1.9	2.1	-0.5	0.9
Depressed Affect (Nagel 2018)	2.7	5.8	11.4	2.0	2.3	2.4	2.1	3.4	-1.4	2.7
Depression (Nagel 2018)	1.8	2.7	6.2	1.0	0.9	1.9	1.8	2.5	-0.5	1.9
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.7	-2.1	0.0	0.3	-1.0	-2.2	1.4	-1.6
Neuroticism (Nagel 2018)	2.1	5.0	10.8	1.3	2.3	2.2	2.5	3.3	-1.0	2.3
Schizophrenia (2018)	0.8	1.6	5.1	-0.0	2.3	-0.6	1.5	1.6	-0.2	0.7
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	-0.7	0.4	-0.5	0.5	-0.2	0.6	-0.9
Worry (Nagel 2018)	0.5	1.0	2.2	0.1	1.1	1.0	1.5	1.3	0.8	0.5
Alzheimer’s Disease (in mother)	0.6	0.6	2.8	1.7	0.5	0.2	-0.1	0.6	-0.2	1.1
Alzheimer’s Disease (in father)	3.0	3.3	4.2	-2.0	-0.7	-1.9	-1.9	-1.9	1.9	-2.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.8	0.2	1.0	-1.0	-0.1	-0.4	1.3	-0.2
Crohns Disease (2017)	0.4	0.9	2.8	0.5	-1.4	-1.1	-1.7	0.0	-0.0	0.4
Irritable Bowel Disease (IBD)	1.4	3.3	11.4	-0.7	-2.8	-1.6	-3.4	-0.8	-0.2	0.4
Ulcerative Colitis (UC)	1.8	3.3	10.9	-1.4	-2.7	-1.4	-3.3	-1.0	-0.4	0.5
Major Depression (MDD)	0.3	0.4	0.9	0.6	0.7	1.0	-0.2	0.8	-0.4	-0.1
Reaction Time	0.8	1.5	5.0	0.6	-0.2	2.2	1.2	1.3	-0.7	1.2
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.9	-1.7	-0.2	-0.7	-1.5	-2.2	1.6	-1.3
Breast Cancer	0.6	1.4	4.4	0.6	-2.1	-0.3	-1.0	0.6	-0.9	1.7
Ovarian Cancer	3.6	4.7	14.4	3.8	-0.7	1.3	0.7	1.9	-2.5	2.5
Prostate Cancer	0.1	0.1	0.8	0.3	0.0	0.9	0.2	0.1	0.3	0.2
Age at First Birth	0.9	1.2	3.7	-0.2	-1.9	-0.8	-1.9	-0.6	-0.1	0.6
Bipolar Disorder (2011)	0.5	0.4	2.0	0.2	-0.6	1.4	-0.1	0.8	-0.1	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.6	-0.1	-0.6	0.2	0.8	-0.6	1.0
Coronary Artery Disease (CAD)	1.4	1.7	5.0	1.1	-0.2	2.2	0.4	1.4	-0.9	1.5
Crohns Disease (2012)	0.3	0.5	1.7	0.5	0.1	-1.3	-0.9	0.2	0.8	0.4
Mean Putamen Volume	0.7	0.8	3.1	0.4	-0.3	1.7	0.3	0.5	-1.3	0.4
Fasting Glucose	0.2	0.2	1.1	-0.5	0.3	-1.0	-0.2	0.0	0.3	-0.3
HbA1C	0.1	0.1	0.2	-0.5	0.2	0.3	0.2	0.2	0.4	-0.1
HDL Cholesterol	1.2	1.9	4.5	-0.6	2.1	-0.0	2.0	-0.7	1.4	-1.5
LDL Cholesterol	0.8	1.3	2.4	0.6	1.5	0.1	1.4	1.4	-0.5	1.4
Lupus	1.6	2.4	6.5	-2.0	1.0	-0.7	0.2	-1.6	1.5	-2.6
Neuroticism (2016)	0.9	1.3	2.6	0.9	1.0	1.4	0.3	1.6	-1.1	1.2
Primary Biliary Cirrhosis	1.9	2.7	5.7	-2.4	-0.8	-1.6	-1.0	-1.4	1.2	-2.2
Rheumatoid Arthritis	1.5	2.1	4.5	-1.8	-0.3	0.4	-0.9	-2.0	1.1	-2.1
Schizophrenia (2014)	1.0	2.1	5.8	0.5	2.4	0.3	2.1	1.9	-0.2	0.8
Triglycerides	0.4	0.7	2.5	0.5	0.2	1.6	-0.2	0.7	-0.5	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	1.3	0.2	-0.2	0.6	1.0	-1.1	0.8
Ulcerative Colitis	2.3	3.3	8.6	-2.2	-2.7	-0.3	-2.9	-1.5	-0.2	-0.2
Blood Eosinophil Count	0.8	5.9	15.4	1.2	2.9	2.1	3.9	2.7	-0.4	2.1
Blood Platelet Count	0.2	2.1	5.5	-0.7	1.4	2.4	1.6	0.0	1.8	-0.8
Blood Red Count	0.1	1.3	4.7	0.7	1.5	1.3	2.2	0.2	0.1	0.2
Blood White Count	0.2	1.2	3.8	0.7	1.5	0.5	2.0	1.1	0.4	-0.2
Heel T-Score	0.1	0.7	2.8	0.3	0.2	1.4	0.6	0.1	1.7	-0.2
BMI	1.7	9.9	22.6	3.1	1.5	1.7	2.5	4.8	-3.2	4.0
Height	0.0	0.1	0.3	-0.2	-0.1	-0.5	0.5	-0.3	-0.2	-0.3
Waist Hip Ratio (WHR)	2.3	10.4	50.3	0.6	2.9	7.1	2.6	1.8	0.3	1.9
Systolic Blood Pressure	0.1	0.7	1.6	-0.4	1.1	1.3	1.0	0.6	0.8	0.4
Smoking Status	0.9	2.2	5.4	1.0	2.2	0.1	2.0	2.3	-0.0	0.4
Allergy or Eczema	2.4	6.2	10.6	2.3	2.1	1.2	2.4	3.2	-2.8	2.9
Cardiovascular Disease	0.5	1.7	3.7	0.4	1.1	1.1	0.4	1.6	1.9	1.8
Hypothyroidism (self reported)	1.4	3.3	6.6	2.0	0.5	1.0	1.1	2.4	-2.1	2.6
Respiratory disease	4.3	9.6	16.4	2.6	3.0	2.4	3.3	4.0	-2.8	3.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	0.2	0.4	1.0	1.0	1.1	-0.6	0.6
Lung FEV1/FVC ratio	0.6	3.2	5.0	-1.9	-2.1	-2.2	-1.8	-1.5	1.4	-1.4
Lung FVC	1.0	5.2	12.3	3.1	-0.1	-0.5	-0.1	2.8	-2.5	3.5
Neuroticism	1.5	3.7	8.0	1.1	2.1	1.6	2.2	2.8	-1.1	2.0
Chronotype (morning person)	0.4	0.9	2.1	-0.7	0.8	0.3	0.3	-1.0	1.4	-1.4
Hair Pigment	0.1	2.7	7.6	-0.8	2.6	1.9	2.8	0.1	0.2	-0.7
Tanning	0.0	0.2	1.2	0.2	-0.3	-1.1	0.3	0.1	-0.2	0.0
Hand grip strength (left)	0.6	1.7	3.3	1.8	-0.9	-0.3	-1.1	1.0	-1.5	1.8
Number of treatments/medications taken	3.5	6.3	11.2	1.0	3.1	3.3	2.9	2.9	-0.9	2.2
Average weekly spirits intake	1.6	1.9	4.9	1.6	-2.2	-1.3	-1.1	0.9	-0.4	1.5
Sensitivity / hurt feelings	0.5	0.9	1.8	-0.0	1.0	1.3	1.1	1.2	-0.2	0.8
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.3	0.7	0.2	1.7	0.9	1.8	-0.8	1.0
Hearing difficulty/problems: Yes	0.1	0.1	0.4	-0.5	0.6	0.3	-0.1	-0.1	-0.4	-0.1
Relative age of first facial hair	0.1	0.3	1.6	0.3	0.3	-0.0	1.2	0.6	-0.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	-0.3	-1.1	-1.3	-0.6	-0.0	-1.2	-0.6
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.8	0.2	1.8	1.4	1.9	1.2	-0.6	1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.9	0.9	-0.1	0.3	0.1	0.6	0.3
Systolic blood pressure, automated reading	0.9	2.6	4.9	-0.0	1.5	2.2	1.8	2.1	-1.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.6	0.5	0.5	0.1	1.2	0.1	0.6	-0.2
Angina	1.1	1.4	4.6	-0.4	1.2	-1.0	-0.1	-0.9	2.1	-1.4
Medication for hormone replacement therapy	1.1	1.3	2.3	0.7	1.3	1.4	0.9	1.5	0.4	1.1
Vitamin and mineral supplements	1.0	1.3	3.0	-1.2	-0.6	-0.9	-0.2	-1.6	1.2	-1.7
Supplements: Zinc	0.6	0.7	1.1	0.5	0.7	0.7	0.8	0.8	-0.9	1.0
Medication: Co-codamol	0.9	1.0	2.6	1.6	1.1	0.6	1.2	0.9	-0.5	0.7
Medication: Metformin	0.2	0.3	1.3	0.3	-1.1	0.0	-0.4	0.2	-0.7	-0.4
Diabetes (father)	0.8	1.0	2.0	-1.4	-0.6	-0.7	-0.6	-1.1	1.2	-1.1
Diabetes (mother)	1.1	1.4	2.3	-0.7	1.1	0.8	0.9	-1.4	1.5	-1.5
Severe depression (siblings)	0.8	0.8	2.2	-0.5	1.3	0.8	1.5	0.9	0.3	0.3
Pack years adult smoking proportion	0.2	0.2	0.9	0.2	-0.2	0.0	0.6	0.9	-0.5	-0.0
Impedance of leg (right)	1.2	5.7	13.5	-2.0	0.1	3.4	-0.1	-2.6	3.7	-1.9
Leg fat-free mass (left)	0.5	2.5	7.1	1.4	0.4	-1.4	1.1	1.7	-2.7	1.4
Trunk fat percentage	0.9	3.4	10.4	0.6	1.6	3.2	2.3	2.0	-0.5	1.0
Hand grip strength (right)	0.1	0.3	0.7	0.6	-0.8	-0.4	-0.7	-0.3	-0.4	0.4
Townsend deprivation index at recruitment	0.4	0.5	2.6	-0.2	-1.6	0.0	-0.9	-0.1	0.3	0.1
Current tobacco smoking	1.3	2.1	6.2	0.3	2.2	-0.8	2.5	1.6	0.5	-0.4
Average weekly fortified wine intake	2.3	2.8	4.5	-2.0	-1.2	-2.1	-1.3	-2.0	0.8	-1.7
Maternal smoking around birth	0.9	1.3	4.1	-0.2	1.8	0.1	2.0	1.2	-0.3	-0.1
Fed-up feelings	1.8	3.3	5.4	1.5	1.9	1.9	2.2	2.3	-1.4	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	3.6	0.4	0.7	1.8	1.5	1.9	-0.1	1.4
Relative age voice broke	1.8	2.7	3.6	1.5	1.8	1.5	1.9	1.8	-1.5	1.4
Taking other prescription medications	3.9	6.0	10.0	2.2	1.7	2.2	2.1	3.2	-2.8	2.7
Age when periods started (menarche)	0.8	1.9	3.5	1.1	1.9	0.9	1.4	1.3	-1.1	1.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	0.2	1.0	-0.5	0.5	0.5	-0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.2	-1.0	-2.0	-0.6	-1.5	-0.3	-0.9	0.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.2	-0.1	0.4	-0.1	0.2	0.1	-0.1	-0.0
Qualifications: CSEs or equivalent	1.7	2.3	7.6	1.7	-0.6	0.9	0.2	1.4	-1.5	2.8
Serious illness, injury or assault to yourself	0.3	0.4	1.9	1.4	-0.3	-0.3	0.3	0.6	-0.3	0.2
High blood pressure	0.4	1.1	2.6	-0.2	1.6	0.7	1.4	1.0	1.1	0.6
Hayfever, allergic rhinitis or eczema	1.9	4.1	6.9	2.0	1.7	1.0	2.3	2.6	-2.2	1.9
Multivitamins +/- minerals	1.1	1.4	3.0	1.0	1.2	0.6	0.9	1.7	-0.9	1.5
Stomach or abdominal pain in last month	0.8	0.9	2.6	1.1	0.5	1.6	1.5	0.4	0.1	0.3
Supplements: Glucosamine	4.7	6.2	9.1	2.3	2.7	2.2	2.3	3.0	-1.9	2.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.4	-1.0	1.8	1.1	1.6	0.2	1.2	-1.8
Medication: Atenolol	2.1	2.6	4.5	-2.1	-0.8	-2.1	-1.4	-1.5	2.0	-0.9
Medication: Levothyroxine sodium	1.1	1.8	2.7	1.5	0.7	1.2	1.2	1.6	-1.3	1.5
Sitting height	0.3	2.2	6.0	-1.2	-0.5	-2.5	-0.1	-1.7	1.1	-1.9
Chronic bronchitis/emphysema (father)	0.9	1.1	4.4	0.6	-1.1	-0.1	-0.6	0.8	-2.1	0.8
High blood pressure (mother)	0.8	1.1	1.9	-1.1	-1.1	1.1	-0.6	-0.8	1.0	-1.4
Body mass index (BMI)	1.7	7.3	16.2	2.2	1.6	1.7	2.4	4.0	-3.1	3.1
Impedance of leg (left)	1.2	5.8	15.1	-2.1	0.2	3.2	0.0	-2.6	3.9	-1.9
Leg predicted mass (left)	0.4	2.4	6.8	1.3	0.4	-1.4	1.2	1.7	-2.6	1.3
Trunk fat mass	1.0	4.3	7.5	1.3	1.6	2.7	2.5	2.6	-1.5	1.7
Waist circumference	1.7	6.0	10.5	1.4	2.2	3.2	2.8	3.1	-1.9	2.1
Number of incorrect matches in round	2.5	4.1	12.9	1.6	0.2	3.6	1.3	2.2	-1.2	2.3
Past tobacco smoking	1.4	2.6	5.6	-1.5	-1.9	-1.5	-1.1	-2.4	0.9	-1.6
Alcohol usually taken with meals	1.4	2.3	5.6	-1.2	-0.5	-1.4	-1.2	-2.1	2.4	-1.1
Nervous feelings	1.1	2.0	4.4	0.7	0.9	1.8	2.1	1.9	-0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	0.9	-0.3	0.8	0.6	0.8	-1.0	0.6
Hearing difficulty/problems with background noise	0.6	1.0	1.8	1.0	1.0	0.8	0.9	1.0	-1.4	0.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.1	-0.3	-0.0	-0.1	0.2	-0.5	0.6
Had menopause	0.4	0.5	1.4	-1.1	1.2	0.7	0.5	0.3	0.5	0.1
Had other major operations	1.1	1.3	2.4	-1.5	1.0	-0.8	0.4	-1.5	1.0	-1.3
Forced vital capacity (FVC)	0.6	2.2	5.1	2.2	-1.1	-0.5	0.2	1.1	-1.9	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.5	-1.8	-1.9	-0.5	-1.4	-0.6	-0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	0.2	1.2	-0.3	0.4	0.3	1.1	0.0
Qualifications: None of the above	0.2	0.3	1.3	0.4	-0.8	-0.1	-0.2	0.4	0.0	1.1
Financial difficulties in last 2 years	0.6	0.9	3.4	-0.1	1.4	0.4	1.8	0.8	-0.1	0.3
Mouth/teeth dental problems	0.8	1.3	3.1	-0.4	-1.8	-0.2	-1.5	-1.4	0.8	-0.8
Heart attack	1.5	1.9	6.5	-1.6	0.7	0.5	0.3	-0.8	2.5	-1.5
Allergy	3.0	6.8	11.2	-2.0	-2.9	-1.8	-3.1	-3.4	2.2	-2.5
Pain all over the body in last month	0.2	0.2	0.5	0.6	-0.2	-0.7	0.1	-0.1	0.6	-0.1
Diabetes (self-reported)	1.1	1.7	4.7	0.6	1.1	2.2	1.9	1.2	-0.5	0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.0	-1.0	-1.7	-0.5	-1.3	-0.2	-1.0	0.1
Medication: Ramipril	0.4	0.6	1.3	-0.5	0.2	-1.2	0.9	0.0	0.9	-0.7
Medication: Simvastatin	1.4	2.0	3.7	1.1	1.6	1.1	1.6	1.9	-0.2	1.8
Fluid intelligence score	0.9	1.9	4.8	-1.4	-0.6	-0.6	-1.6	-2.2	1.0	-1.5
Illnesses of siblings	2.7	3.7	9.2	-1.0	-2.3	-2.2	-3.0	-1.9	0.1	-1.4
Neuroticism score	1.3	2.8	5.0	1.3	1.4	1.7	2.0	2.2	-1.3	1.5
Weight	1.0	5.0	9.4	1.9	0.9	1.2	2.3	3.1	-2.9	2.5
Impedance of arm (right)	2.3	10.5	22.1	-3.3	-0.3	0.7	-1.0	-4.5	4.7	-4.4
Arm fat percentage (right)	1.0	4.0	8.1	1.3	1.6	2.4	2.3	2.8	-1.5	1.7
Trunk fat-free mass	1.1	6.3	14.2	2.8	0.3	-0.7	1.5	3.1	-3.8	3.2
Hip circumference	0.2	1.0	2.6	0.4	0.7	-0.2	1.6	1.4	-1.4	0.5
Time employed in main current job	0.3	0.3	1.3	0.2	-1.1	0.3	-0.0	0.3	-0.7	0.4
Alcohol intake versus 10 years previously	0.5	0.7	2.4	0.2	0.3	0.6	1.3	0.4	-1.6	0.5
Father’s age at death	0.1	0.2	0.6	-0.2	-0.8	-0.1	-0.6	-0.3	-0.3	0.1
Worrier / anxious feelings	0.1	0.3	0.8	0.0	-0.3	0.9	0.0	0.4	-0.0	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	6.8	0.5	1.4	2.6	1.7	1.8	-0.5	1.0
Falls in the last year	1.3	1.8	3.8	1.1	0.4	1.3	0.9	1.9	-1.2	1.9
Hair/balding pattern: Pattern 3	0.2	0.2	1.2	-0.2	-0.3	1.1	-0.4	-0.3	0.2	0.2
Number of live births	4.2	5.9	9.1	1.7	3.0	2.4	2.9	2.9	-1.4	2.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.6	1.3	-1.6	-1.0	-0.3	0.4	-1.1	1.2
Pulse rate	0.4	0.7	1.7	0.5	0.6	0.2	0.9	1.3	-0.2	1.3
Happiness	1.9	2.3	3.8	1.4	1.4	1.0	1.9	1.9	-1.0	1.7
Noisy workplace	0.9	1.2	3.6	0.8	0.2	-0.7	0.7	1.9	-0.9	1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.4	2.5	-1.2	-0.8	1.2	-1.3	-1.3	0.8	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.7	-0.1	-0.4	-1.0	0.2	-1.1	0.6	-1.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.5	-0.5	-0.9	-0.9	-0.4	0.2	-0.2
Asthma	3.9	7.7	11.9	2.2	3.5	2.1	3.2	3.3	-2.2	2.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	8.1	-0.2	2.8	1.3	1.5	-0.0	1.5	-0.6
Medication: Cholesterol lowering	0.8	1.2	3.2	1.3	0.4	0.6	0.8	1.8	-0.6	1.4
Depression (self-reported)	0.8	1.0	1.7	1.1	0.8	1.0	1.3	1.3	-0.2	0.8
Medication: Lansoprazole	0.6	0.7	1.4	0.9	0.3	1.1	0.4	0.9	-0.8	1.2
Prospective memory result	1.9	2.3	6.8	2.6	0.4	1.2	0.9	1.4	-1.7	1.5
Lung cancer (father)	0.8	0.9	3.9	1.2	0.4	2.0	0.3	0.6	-0.4	0.4
Illnesses of mother	0.4	0.5	0.9	0.8	-0.4	-0.6	-1.0	0.4	-0.6	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	4.2	0.6	-2.0	-1.2	-1.0	-0.2	-0.8	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	1.8	-0.0	1.4	-0.2	0.7	0.6	0.2	-0.0
Impedance of arm (left)	2.1	9.8	21.5	-3.2	-0.1	1.0	-1.0	-4.2	4.6	-4.2
Arm fat mass (right)	1.4	5.7	11.4	1.6	1.8	2.0	2.7	3.4	-2.5	2.3
Trunk predicted mass	1.1	6.2	13.7	2.7	0.3	-0.6	1.5	3.1	-3.7	3.2
Standing height	0.0	0.4	1.3	-0.2	-0.9	-0.5	0.3	-1.1	-0.3	-0.4
Length of working week for main job	2.0	2.2	5.4	-1.8	1.0	-1.5	-0.4	-1.2	2.3	-1.4
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.8	0.7	0.4	0.8	0.2	-0.4	-0.4
Breastfed as a baby	0.6	0.8	1.7	1.0	0.7	0.8	-0.0	1.1	-1.3	0.5
Tense / ‘highly strung’	0.2	0.3	0.8	0.4	0.3	0.4	0.9	0.5	-0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	5.0	0.7	2.2	0.6	2.0	1.4	-0.9	-0.3
Hair/balding pattern: Pattern 4	0.8	1.8	2.7	-1.6	-0.5	-1.3	-1.6	-1.3	1.4	-1.4
Birth weight of first child	1.4	2.6	4.0	-1.8	-0.9	-2.0	-0.1	-2.0	1.4	-1.9
Peak expiratory flow (PEF)	0.3	0.8	2.8	0.9	-0.7	-1.7	-0.2	0.2	-0.4	1.0
Pulse wave reflection index	0.8	1.0	2.9	-0.3	0.5	-0.2	-0.5	-1.1	1.5	-1.7
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.5	0.1	0.3	-0.1	0.7	0.3	-0.4	-0.5
Loud music exposure frequency	1.0	1.1	3.4	-0.1	0.7	0.1	0.9	-1.0	1.9	-1.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.0	-1.1	-1.2	0.3	-1.7	-1.2	-0.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	0.2	-0.4	0.1	0.6	0.1	-0.9	-0.2
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.2	1.0	0.3	0.5	0.6	0.7	0.5
Medication: Paracetamol	0.8	1.3	2.2	1.4	1.3	0.7	1.1	1.5	-0.3	1.1
Headache pain in last month	1.8	3.1	10.8	1.5	1.5	3.3	1.5	1.6	-0.1	1.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.5	-1.1	-0.4	-0.8	-1.2	-2.3	0.9	-2.2
Glaucoma (self-reported)	1.8	2.1	7.3	1.8	0.1	2.7	1.1	1.2	-0.3	1.1
Gout (self-reported)	0.6	0.8	2.7	1.0	-0.4	1.6	0.5	0.1	1.2	0.3
Hypothyroidism/myxoedema (self-reported)	2.1	4.1	7.1	1.7	0.8	1.4	1.7	2.6	-2.7	2.5
Medication: Amlodipine	0.2	0.3	0.8	-0.3	-0.5	0.9	0.8	-0.1	0.3	0.1
Medication: Ventolin 100micrograms inhaler	3.4	4.3	6.6	2.2	1.7	1.1	1.9	2.4	-2.3	2.6
Birth weight	0.4	0.9	3.9	2.0	-0.3	0.3	-0.1	0.8	-1.0	0.8
Chronic bronchitis/emphysema (mother)	2.2	2.5	5.5	-1.2	2.3	0.7	2.2	-0.1	2.1	-1.2
High blood pressure (siblings)	1.3	1.9	4.6	0.2	1.9	1.3	2.1	1.4	0.2	1.0
Forced vital capacity (FVC), Best measure	0.3	1.1	1.9	1.2	-1.4	-0.7	-0.4	0.5	-1.4	1.2
Body fat percentage	1.1	4.4	11.0	1.0	1.7	3.3	2.4	2.5	-1.0	1.6
Leg fat percentage (right)	2.0	7.1	15.4	1.6	2.2	3.9	2.6	3.3	-1.7	2.4
Arm fat-free mass (right)	1.2	6.0	12.8	2.4	0.4	-0.2	1.5	3.1	-3.6	3.3
Exposure to tobacco smoke outside home	1.4	1.9	6.0	-1.7	0.2	-0.9	-0.4	-1.6	0.9	-2.5
Comparative body size at age 10	0.6	1.6	3.8	0.8	0.3	-0.2	1.9	1.6	-1.8	1.1
Number of full brothers	1.7	2.1	4.1	0.1	2.0	1.5	2.0	2.0	0.1	0.7
Worry too long after embarrassment	1.5	2.5	5.2	0.8	2.1	1.8	2.3	1.6	-1.0	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.2	0.4	0.4	0.1	1.2	-1.0	0.2
Wheeze or whistling in the chest in last year	6.0	10.7	17.0	3.5	2.2	4.1	3.0	3.8	-2.3	3.5
Number of children fathered	1.1	1.3	3.9	0.2	1.1	0.1	2.0	1.5	-1.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.7	-1.6	1.0	-1.0	-0.1	-0.6	1.6	-1.4
Age at first live birth	1.2	2.1	8.3	0.5	-2.9	-0.4	-2.2	-0.9	-0.6	-0.1
Pulse wave peak to peak time	0.4	0.5	2.2	0.0	-1.5	-0.1	-0.7	-0.7	-0.3	0.0
Health satisfaction	0.7	0.9	2.2	0.4	0.6	0.7	1.5	1.2	-1.3	-0.2
Shortness of breath walking on level ground	3.0	3.6	6.4	2.5	0.7	2.1	1.4	2.3	-1.3	2.2
Qualifications: College or University degree	0.7	2.4	5.8	-1.8	-1.5	0.6	-1.3	-2.4	0.9	-1.6
Eye problems/disorders: None of the above	0.9	1.0	2.6	-1.4	-1.3	-0.4	-1.6	-0.7	0.0	-0.0
Mouth/teeth dental problems: Loose teeth	1.2	1.5	4.0	0.5	2.0	-0.2	1.9	1.2	-1.0	0.2
Emphysema/chronic bronchitis	2.6	2.9	5.9	1.1	1.3	2.4	2.3	2.2	-0.7	1.0
Medication for pain relief, constipation, heartburn	1.0	1.8	6.7	-0.1	-2.6	-1.4	-1.4	-1.3	-0.2	-0.3
Neck or shoulder pain in last month	2.1	3.0	7.5	1.5	2.7	1.7	2.2	1.6	0.2	1.1
Medication: Blood pressure	0.4	0.8	2.3	0.4	0.0	0.5	0.8	1.3	0.6	1.5
Angina (self-reported)	1.0	1.4	4.2	-0.5	0.9	-1.0	-0.2	-1.1	2.0	-1.5
Migraine (self-reported)	0.2	0.2	0.7	0.2	0.0	-0.3	0.8	0.0	-0.7	-0.0
Medication: Ibuprofen	3.2	3.8	12.9	-0.4	3.6	2.0	2.2	0.1	2.0	-0.8
Medication: Allopurinol	1.2	1.6	5.0	1.3	1.1	2.2	1.2	0.9	1.0	0.4
Medication: Omeprazole	1.5	1.7	3.2	1.2	1.2	1.1	0.9	1.8	-1.5	1.4
Medication: Seretide 50 evohaler	3.9	4.5	7.7	2.7	0.4	2.2	1.1	2.8	-2.1	2.5
Mean time to correctly identify matches	1.6	3.0	10.1	1.1	0.2	3.2	1.7	1.8	-0.9	1.7
Heart disease (mother)	0.7	0.9	2.0	-1.4	0.3	-1.4	-0.0	-0.6	1.0	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.5	0.7	-0.5	0.6	-0.4	0.5	-0.5
Whole body fat mass	1.2	4.9	9.2	1.4	1.7	2.4	2.6	3.0	-1.9	2.0
Leg fat mass (right)	1.4	5.6	10.5	1.8	1.6	2.5	2.3	3.2	-2.3	2.5
Arm predicted mass (right)	1.1	5.7	10.9	2.2	0.8	-0.3	2.0	3.1	-3.3	3.1
Pulse rate, automated reading	0.6	1.8	3.8	1.2	0.4	0.5	0.9	1.8	-1.9	1.7
Alcohol intake frequency.	0.3	0.7	1.6	-0.5	1.0	-0.4	1.0	-0.7	0.3	-1.2
Comparative height size at age 10	0.1	0.7	3.2	-0.5	-0.3	-1.8	0.3	-0.5	-0.9	-0.5
Number of full sisters	2.1	2.5	6.1	0.3	1.2	2.1	2.5	1.6	0.1	1.7
Suffer from ‘nerves’	0.5	0.7	2.6	-0.3	0.7	1.0	1.6	0.9	0.1	-0.2
Overall health rating	2.5	5.4	11.2	1.2	2.8	2.5	3.3	2.7	-1.8	1.1
Chest pain or discomfort	0.2	0.3	1.6	0.1	-0.1	1.3	-0.6	-0.0	-0.1	0.6
Had major operations	0.3	0.3	1.7	-0.1	1.3	-0.0	0.6	0.3	0.2	-0.5
Age at last live birth	0.6	0.9	2.0	1.1	-0.4	1.4	0.8	0.7	-1.2	0.4
Family relationship satisfaction	1.1	1.3	2.0	0.5	1.3	1.3	1.4	1.4	-1.2	0.7
Leg pain on walking	0.9	1.2	2.3	0.3	1.4	0.8	1.5	1.3	-1.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	1.1	0.6	-0.2	-0.4	0.9	0.0	0.8
Commuting to job workplace: Car/motor vehicle	2.4	2.8	5.4	1.5	1.2	1.5	2.3	2.2	-1.3	1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.1	-0.5	0.2	0.2	-0.4	-1.1	0.5	-0.1
Medication: Aspirin	0.7	0.9	3.4	-1.9	-0.0	-0.6	-0.4	-0.6	1.1	-0.9
Supplements: Vitamin C	0.7	0.9	1.8	0.9	0.6	0.7	0.4	0.8	-1.3	1.3
Knee pain experienced in last month	1.8	2.8	5.6	2.4	1.1	0.4	1.2	2.2	-2.3	1.1
Hypertension (Self-reported)	0.3	0.9	1.9	-0.3	1.2	0.6	1.0	0.8	1.4	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.6	0.5	-0.1	1.5	0.1	1.2	-0.3	1.6
Illnesses of father: Heart disease	0.4	0.5	2.0	-0.0	-0.2	0.8	0.4	0.7	-0.6	1.4
Illnesses of siblings: Diabetes	0.8	0.9	3.9	0.5	1.1	0.9	2.0	0.1	0.0	-0.6
Smoking status: Previous	1.2	1.8	3.6	1.1	1.1	1.6	0.6	1.9	-0.7	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	-0.2	-1.3	-1.1	-0.8	-1.4	1.1	-0.9
Whole body fat-free mass	0.8	4.8	11.4	2.3	0.3	-0.9	1.4	2.6	-3.4	2.7
Leg fat-free mass (right)	0.4	2.2	5.3	1.1	0.3	-1.9	1.1	1.5	-2.3	1.2
Arm fat percentage (left)	1.0	3.9	8.0	1.1	1.8	2.4	2.2	2.8	-1.4	1.6
Average weekly red wine intake	0.3	0.5	1.8	0.6	0.2	0.3	-0.2	0.9	-0.6	1.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.3	0.0	-0.6	-1.8	-1.5	-0.9	-1.1	-0.2
Mood swings	5.0	9.0	14.9	3.0	1.0	3.9	1.8	3.7	-3.0	3.5
Loneliness, isolation	2.5	3.4	8.6	1.1	2.9	1.8	2.7	1.7	-0.2	0.8
Long-standing illness, disability or infirmity	3.8	5.8	10.6	1.9	2.0	1.8	2.3	3.2	-2.8	2.5
Ever had bowel cancer screening	0.3	0.3	1.2	-0.3	0.9	-0.4	0.3	0.3	1.1	0.1
Diabetes diagnosed by doctor	0.3	0.6	1.8	0.4	0.5	1.3	1.2	0.6	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.6	-0.6	-0.8	-0.4	-0.7	0.9	-0.1
Friendships satisfaction	0.7	0.8	2.3	0.0	1.2	1.5	1.1	0.7	-0.3	0.7
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.5	0.8	-0.5	0.7	-0.2	-0.4	-0.8
Commuting to job workplace: Walk	4.5	4.9	7.9	-1.9	-2.5	-0.8	-2.8	-2.6	2.2	-2.0
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.5	0.4	0.6	0.3	0.5	-0.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.3	-0.4	0.6	0.9	0.1	0.3	-0.0	1.1
Medication for cholesterol	0.9	1.4	3.3	0.7	-1.8	-0.9	-1.0	-0.8	-1.8	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.8	-0.6	1.7	-0.1	0.6	-0.6	0.7	-0.8
Back pain experienced in last month	0.2	0.3	1.0	0.8	1.0	0.2	0.6	0.3	-0.1	0.2
Mineral and other dietary supplements	5.3	7.2	11.8	-3.0	-2.3	-2.0	-1.8	-3.2	2.7	-3.4
Breast cancer (self-reported)	2.5	3.0	10.8	-1.4	-1.0	-3.3	-1.3	-1.5	0.9	-1.5
Asthma (self-reported)	4.6	9.1	13.4	2.6	3.7	2.2	3.4	3.6	-2.3	3.0
Osteoporosis (self-reported)	1.6	2.0	4.6	0.4	-1.6	-1.5	-2.2	-1.5	-0.1	-1.3
Osteoarthritis (self-reported)	3.8	4.9	9.5	1.7	3.1	1.8	2.2	2.5	-1.4	2.2
Medication: Aspirin	0.6	0.8	3.2	-1.8	-0.0	-0.6	-0.5	-0.4	1.1	-0.7
Medication: Gliclazide	0.7	0.8	3.1	0.3	-1.1	-0.5	-0.9	0.1	-1.8	0.1
Illnesses of father: None of the above (group 1)	0.8	1.0	2.0	1.0	-1.2	-1.4	-1.1	-0.4	-0.9	0.0
Smoking status: Current	1.1	1.8	5.0	0.4	1.8	-0.8	2.2	1.8	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	-0.0	-1.1	-1.2	-1.1	-0.3	-0.3	0.4
Whole body water mass	0.8	4.7	11.2	2.3	0.2	-1.0	1.4	2.6	-3.3	2.6
Leg predicted mass (right)	0.4	2.1	5.2	1.1	0.3	-2.0	1.1	1.4	-2.3	1.1
Arm fat mass (left)	1.3	5.3	10.8	1.5	1.8	2.0	2.6	3.3	-2.3	2.3
Number of self-reported non-cancer illnesses	1.0	1.7	3.8	-0.3	1.3	2.0	1.4	1.6	-0.2	1.4
Average weekly champagne plus white wine intake	4.5	6.2	14.8	-2.2	-0.9	-1.0	-1.7	-3.2	3.9	-2.9
Miserableness	3.9	6.8	9.9	2.8	2.0	2.3	2.2	3.1	-2.9	2.8
Guilty feelings	0.7	1.0	2.9	-0.1	0.9	1.1	1.7	1.4	-0.7	-0.0
Wears glasses or contact lenses	0.6	0.6	3.0	-0.5	0.1	0.7	0.8	-0.3	0.2	-1.7
Ever taken oral contraceptive pill	1.9	2.1	6.2	0.7	1.8	1.3	2.5	1.5	-0.3	0.6
Hearing aid user	2.0	2.3	7.4	1.2	-1.7	0.2	-0.8	0.9	-2.7	1.6
Mother’s age at death	0.2	0.2	0.6	0.8	-0.0	0.3	0.3	0.3	0.1	0.7
Financial situation satisfaction	0.4	0.5	2.1	0.3	1.2	0.2	1.4	0.3	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	1.0	-0.3	-1.0	0.1	0.8	0.5	0.6
Commuting to job workplace: Public transport	1.3	1.6	3.0	-1.1	-1.0	-1.1	-0.9	-1.7	1.3	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.9	1.2	-0.2	1.7	0.9	0.6	-0.3	0.6
Medication: Blood pressure	0.8	1.6	3.0	-1.0	1.6	1.2	1.2	-0.2	1.7	-1.1
Pain type(s) experienced in last month: Hip pain	6.3	8.0	15.1	3.7	1.3	0.2	1.0	3.4	-3.9	3.6
Supplements: Fish oil (including cod liver oil)	5.8	7.5	13.5	2.9	1.5	2.6	1.5	3.0	-3.2	3.7
High cholesterol (Self-reported)	1.3	2.3	6.4	1.5	1.2	0.5	0.5	2.3	-0.7	2.5
Medication: Bendroflumethiazide	0.6	0.8	1.9	1.1	1.0	1.4	0.9	0.5	0.8	0.1
Medication: Paracetamol	0.8	1.2	3.6	0.6	1.9	0.9	1.3	1.0	0.7	0.7
Medication: Lisinopril	0.8	1.0	4.2	-0.6	2.1	0.3	0.7	0.9	1.1	0.3
Medication: Atorvastatin	0.1	0.1	0.7	-0.1	-0.2	0.1	0.0	0.8	-0.4	-0.1
Illnesses of father: High blood pressure	0.8	1.0	3.9	0.0	2.0	0.7	1.1	0.4	1.1	0.1
Alcohol drinker status: Never	1.0	1.2	3.3	-0.9	1.8	0.1	1.6	0.1	0.2	-1.3
Ever smoked	0.4	0.7	2.3	0.6	1.5	0.4	0.7	1.3	-0.0	0.3
Basal metabolic rate	0.8	4.5	10.0	2.1	0.5	-0.6	1.7	2.6	-3.2	2.5
Leg fat percentage (left)	2.1	7.6	14.0	1.8	2.4	3.7	2.9	3.5	-1.7	2.7
Arm fat-free mass (left)	1.3	6.7	12.9	2.6	0.6	0.1	2.1	3.3	-3.6	3.3
Number of operations (self-reported)	1.3	1.9	4.9	-1.2	1.0	-1.9	0.4	-1.5	0.3	-2.2
Average weekly beer plus cider intake	0.5	0.7	3.3	-0.1	-0.6	0.5	0.1	0.9	-1.8	0.6
Irritability	1.2	2.0	4.2	1.3	-0.2	0.7	0.5	2.0	-1.9	1.9
Risk taking	2.0	3.0	5.7	1.1	2.1	0.5	2.0	2.0	-2.4	1.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.0	0.0	0.1	-1.0	-0.2	-0.3	-0.5	-0.5
Fractured/broken bones in last 5 years	3.3	4.3	7.2	2.7	1.4	1.7	2.2	2.3	-1.4	2.5
Age started oral contraceptive pill	0.3	0.4	1.5	-0.6	0.3	1.2	0.6	0.4	0.2	0.4
Diastolic blood pressure, automated reading	0.3	0.9	2.5	-0.7	0.4	0.5	0.6	1.2	-1.6	1.1
Ever depressed for a whole week	1.5	1.8	6.2	1.1	2.5	0.5	1.9	1.1	-0.4	0.4
Unable to work because of sickness or disability	0.3	0.4	1.0	0.5	0.7	0.6	0.6	0.6	-1.0	0.4
Commuting to job workplace: Cycle	2.8	3.4	7.4	-1.7	-0.9	-0.1	-2.1	-2.7	1.9	-2.2
Myopia	0.3	0.4	1.7	0.4	-1.3	0.1	-0.5	-0.8	0.4	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.2	1.0	-1.3	-0.3	-1.1	-0.4	-1.8	0.1
Cholesterol lowering medication	0.6	0.8	1.8	-0.2	1.3	1.1	0.5	1.3	0.3	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	0.2	1.0	0.9	0.5	1.2	-1.1	1.1
Pain experienced in last month	1.3	2.2	4.1	-2.0	-1.4	-1.2	-1.7	-1.4	1.3	-1.2
Supplements: Calcium	0.4	0.4	1.1	0.6	0.3	0.1	0.3	0.5	-1.1	1.0
Basal cell carcinoma (self-reported)	0.6	0.7	2.7	0.7	1.0	0.1	1.6	0.3	-0.5	0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	5.1	-1.3	0.5	0.3	0.1	-0.6	2.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.0	-0.5	0.9	-0.1	0.3	0.3	1.0	0.2
Heart disease (siblings)	1.0	1.2	2.7	0.9	0.1	-0.1	0.7	1.5	-1.6	1.5
Alcohol drinker status: Previous	0.2	0.2	0.6	0.2	0.7	-0.1	0.7	0.3	0.5	-0.3
Pack years of smoking	0.2	0.3	1.1	0.3	-0.2	0.1	0.5	1.1	-0.6	0.1
Impedance of whole body	1.9	9.6	23.1	-3.1	-0.1	2.3	-0.5	-3.9	4.8	-3.6
Leg fat mass (left)	1.7	6.5	12.3	1.9	1.9	2.6	2.6	3.5	-2.3	2.7
Arm predicted mass (left)	1.1	5.5	10.5	2.3	0.6	-0.2	1.9	3.0	-3.2	3.0