Hub : Genes

STIM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pituitary 0.2470 0.0910 6.8e-03 0.069 NA 0.043 NA 0.081 8.3e-03 NA 3.1e-02 NA 4.6e-03
2 GTEx Whole Blood 0.0920 0.0370 4.3e-03 0.034 NA 0.044 NA 0.033 4.2e-04 NA 6.1e-05 NA 5.0e-04
3 METSIM Adipose 0.0488 0.0194 2.2e-03 0.005 0.010 0.000 0.008 -0.002 4.6e-02 1.1e-02 2.7e-01 1.8e-02 9.1e-01
4 NTR Blood 0.0544 0.0120 1.8e-13 0.047 0.041 0.054 0.048 0.055 6.4e-15 2.8e-13 8.0e-17 3.2e-15 3.0e-17
5 ROSMAP Brain Pre-frontal Cortex 0.0840 0.0214 8.7e-09 0.082 0.076 0.078 0.075 0.079 9.6e-11 5.3e-10 3.1e-10 7.5e-10 2.3e-10
6 YFS Blood 0.2475 0.0318 0.0e+00 0.095 0.200 0.199 0.191 0.186 2.1e-29 3.0e-63 4.1e-63 2.2e-60 1.2e-58
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0285 0.0165 7.1e-03 0.005 0.009 0.002 NA 0.002 7.7e-02 2.6e-02 1.5e-01 NA 1.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.6 0.9 1.7 0.2 1.0 1.3 1.1 1.3 -0.6 0.5
Bipolar Disorder or Schizophrenia 0.9 2.1 5.6 0.2 2.4 0.4 1.9 2.1 -0.5 0.9
Depressed Affect (Nagel 2018) 2.7 5.8 11.4 2.0 2.3 2.4 2.1 3.4 -1.4 2.7
Depression (Nagel 2018) 1.8 2.7 6.2 1.0 0.9 1.9 1.8 2.5 -0.5 1.9
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.7 -2.1 0.0 0.3 -1.0 -2.2 1.4 -1.6
Neuroticism (Nagel 2018) 2.1 5.0 10.8 1.3 2.3 2.2 2.5 3.3 -1.0 2.3
Schizophrenia (2018) 0.8 1.6 5.1 -0.0 2.3 -0.6 1.5 1.6 -0.2 0.7
Schizophrenia vs Biploar Disorder 0.3 0.3 0.9 -0.7 0.4 -0.5 0.5 -0.2 0.6 -0.9
Worry (Nagel 2018) 0.5 1.0 2.2 0.1 1.1 1.0 1.5 1.3 0.8 0.5
Alzheimer’s Disease (in mother) 0.6 0.6 2.8 1.7 0.5 0.2 -0.1 0.6 -0.2 1.1
Alzheimer’s Disease (in father) 3.0 3.3 4.2 -2.0 -0.7 -1.9 -1.9 -1.9 1.9 -2.0
Alzheimer’s Disease (including proxy) 0.4 0.6 1.8 0.2 1.0 -1.0 -0.1 -0.4 1.3 -0.2
Crohns Disease (2017) 0.4 0.9 2.8 0.5 -1.4 -1.1 -1.7 0.0 -0.0 0.4
Irritable Bowel Disease (IBD) 1.4 3.3 11.4 -0.7 -2.8 -1.6 -3.4 -0.8 -0.2 0.4
Ulcerative Colitis (UC) 1.8 3.3 10.9 -1.4 -2.7 -1.4 -3.3 -1.0 -0.4 0.5
Major Depression (MDD) 0.3 0.4 0.9 0.6 0.7 1.0 -0.2 0.8 -0.4 -0.1
Reaction Time 0.8 1.5 5.0 0.6 -0.2 2.2 1.2 1.3 -0.7 1.2
Verbal and Numeric Reasoning (VNR) 0.9 2.1 4.9 -1.7 -0.2 -0.7 -1.5 -2.2 1.6 -1.3
Breast Cancer 0.6 1.4 4.4 0.6 -2.1 -0.3 -1.0 0.6 -0.9 1.7
Ovarian Cancer 3.6 4.7 14.4 3.8 -0.7 1.3 0.7 1.9 -2.5 2.5
Prostate Cancer 0.1 0.1 0.8 0.3 0.0 0.9 0.2 0.1 0.3 0.2
Age at First Birth 0.9 1.2 3.7 -0.2 -1.9 -0.8 -1.9 -0.6 -0.1 0.6
Bipolar Disorder (2011) 0.5 0.4 2.0 0.2 -0.6 1.4 -0.1 0.8 -0.1 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 0.6 -0.1 -0.6 0.2 0.8 -0.6 1.0
Coronary Artery Disease (CAD) 1.4 1.7 5.0 1.1 -0.2 2.2 0.4 1.4 -0.9 1.5
Crohns Disease (2012) 0.3 0.5 1.7 0.5 0.1 -1.3 -0.9 0.2 0.8 0.4
Mean Putamen Volume 0.7 0.8 3.1 0.4 -0.3 1.7 0.3 0.5 -1.3 0.4
Fasting Glucose 0.2 0.2 1.1 -0.5 0.3 -1.0 -0.2 0.0 0.3 -0.3
HbA1C 0.1 0.1 0.2 -0.5 0.2 0.3 0.2 0.2 0.4 -0.1
HDL Cholesterol 1.2 1.9 4.5 -0.6 2.1 -0.0 2.0 -0.7 1.4 -1.5
LDL Cholesterol 0.8 1.3 2.4 0.6 1.5 0.1 1.4 1.4 -0.5 1.4
Lupus 1.6 2.4 6.5 -2.0 1.0 -0.7 0.2 -1.6 1.5 -2.6
Neuroticism (2016) 0.9 1.3 2.6 0.9 1.0 1.4 0.3 1.6 -1.1 1.2
Primary Biliary Cirrhosis 1.9 2.7 5.7 -2.4 -0.8 -1.6 -1.0 -1.4 1.2 -2.2
Rheumatoid Arthritis 1.5 2.1 4.5 -1.8 -0.3 0.4 -0.9 -2.0 1.1 -2.1
Schizophrenia (2014) 1.0 2.1 5.8 0.5 2.4 0.3 2.1 1.9 -0.2 0.8
Triglycerides 0.4 0.7 2.5 0.5 0.2 1.6 -0.2 0.7 -0.5 1.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 1.3 0.2 -0.2 0.6 1.0 -1.1 0.8
Ulcerative Colitis 2.3 3.3 8.6 -2.2 -2.7 -0.3 -2.9 -1.5 -0.2 -0.2
Blood Eosinophil Count 0.8 5.9 15.4 1.2 2.9 2.1 3.9 2.7 -0.4 2.1
Blood Platelet Count 0.2 2.1 5.5 -0.7 1.4 2.4 1.6 0.0 1.8 -0.8
Blood Red Count 0.1 1.3 4.7 0.7 1.5 1.3 2.2 0.2 0.1 0.2
Blood White Count 0.2 1.2 3.8 0.7 1.5 0.5 2.0 1.1 0.4 -0.2
Heel T-Score 0.1 0.7 2.8 0.3 0.2 1.4 0.6 0.1 1.7 -0.2
BMI 1.7 9.9 22.6 3.1 1.5 1.7 2.5 4.8 -3.2 4.0
Height 0.0 0.1 0.3 -0.2 -0.1 -0.5 0.5 -0.3 -0.2 -0.3
Waist Hip Ratio (WHR) 2.3 10.4 50.3 0.6 2.9 7.1 2.6 1.8 0.3 1.9
Systolic Blood Pressure 0.1 0.7 1.6 -0.4 1.1 1.3 1.0 0.6 0.8 0.4
Smoking Status 0.9 2.2 5.4 1.0 2.2 0.1 2.0 2.3 -0.0 0.4
Allergy or Eczema 2.4 6.2 10.6 2.3 2.1 1.2 2.4 3.2 -2.8 2.9
Cardiovascular Disease 0.5 1.7 3.7 0.4 1.1 1.1 0.4 1.6 1.9 1.8
Hypothyroidism (self reported) 1.4 3.3 6.6 2.0 0.5 1.0 1.1 2.4 -2.1 2.6
Respiratory disease 4.3 9.6 16.4 2.6 3.0 2.4 3.3 4.0 -2.8 3.3
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.2 0.2 0.4 1.0 1.0 1.1 -0.6 0.6
Lung FEV1/FVC ratio 0.6 3.2 5.0 -1.9 -2.1 -2.2 -1.8 -1.5 1.4 -1.4
Lung FVC 1.0 5.2 12.3 3.1 -0.1 -0.5 -0.1 2.8 -2.5 3.5
Neuroticism 1.5 3.7 8.0 1.1 2.1 1.6 2.2 2.8 -1.1 2.0
Chronotype (morning person) 0.4 0.9 2.1 -0.7 0.8 0.3 0.3 -1.0 1.4 -1.4
Hair Pigment 0.1 2.7 7.6 -0.8 2.6 1.9 2.8 0.1 0.2 -0.7
Tanning 0.0 0.2 1.2 0.2 -0.3 -1.1 0.3 0.1 -0.2 0.0
Hand grip strength (left) 0.6 1.7 3.3 1.8 -0.9 -0.3 -1.1 1.0 -1.5 1.8
Number of treatments/medications taken 3.5 6.3 11.2 1.0 3.1 3.3 2.9 2.9 -0.9 2.2
Average weekly spirits intake 1.6 1.9 4.9 1.6 -2.2 -1.3 -1.1 0.9 -0.4 1.5
Sensitivity / hurt feelings 0.5 0.9 1.8 -0.0 1.0 1.3 1.1 1.2 -0.2 0.8
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.3 0.7 0.2 1.7 0.9 1.8 -0.8 1.0
Hearing difficulty/problems: Yes 0.1 0.1 0.4 -0.5 0.6 0.3 -0.1 -0.1 -0.4 -0.1
Relative age of first facial hair 0.1 0.3 1.6 0.3 0.3 -0.0 1.2 0.6 -0.1 0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.6 -0.3 -1.1 -1.3 -0.6 -0.0 -1.2 -0.6
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.8 0.2 1.8 1.4 1.9 1.2 -0.6 1.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 -0.9 0.9 -0.1 0.3 0.1 0.6 0.3
Systolic blood pressure, automated reading 0.9 2.6 4.9 -0.0 1.5 2.2 1.8 2.1 -1.1 1.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.6 0.5 0.5 0.1 1.2 0.1 0.6 -0.2
Angina 1.1 1.4 4.6 -0.4 1.2 -1.0 -0.1 -0.9 2.1 -1.4
Medication for hormone replacement therapy 1.1 1.3 2.3 0.7 1.3 1.4 0.9 1.5 0.4 1.1
Vitamin and mineral supplements 1.0 1.3 3.0 -1.2 -0.6 -0.9 -0.2 -1.6 1.2 -1.7
Supplements: Zinc 0.6 0.7 1.1 0.5 0.7 0.7 0.8 0.8 -0.9 1.0
Medication: Co-codamol 0.9 1.0 2.6 1.6 1.1 0.6 1.2 0.9 -0.5 0.7
Medication: Metformin 0.2 0.3 1.3 0.3 -1.1 0.0 -0.4 0.2 -0.7 -0.4
Diabetes (father) 0.8 1.0 2.0 -1.4 -0.6 -0.7 -0.6 -1.1 1.2 -1.1
Diabetes (mother) 1.1 1.4 2.3 -0.7 1.1 0.8 0.9 -1.4 1.5 -1.5
Severe depression (siblings) 0.8 0.8 2.2 -0.5 1.3 0.8 1.5 0.9 0.3 0.3
Pack years adult smoking proportion 0.2 0.2 0.9 0.2 -0.2 0.0 0.6 0.9 -0.5 -0.0
Impedance of leg (right) 1.2 5.7 13.5 -2.0 0.1 3.4 -0.1 -2.6 3.7 -1.9
Leg fat-free mass (left) 0.5 2.5 7.1 1.4 0.4 -1.4 1.1 1.7 -2.7 1.4
Trunk fat percentage 0.9 3.4 10.4 0.6 1.6 3.2 2.3 2.0 -0.5 1.0
Hand grip strength (right) 0.1 0.3 0.7 0.6 -0.8 -0.4 -0.7 -0.3 -0.4 0.4
Townsend deprivation index at recruitment 0.4 0.5 2.6 -0.2 -1.6 0.0 -0.9 -0.1 0.3 0.1
Current tobacco smoking 1.3 2.1 6.2 0.3 2.2 -0.8 2.5 1.6 0.5 -0.4
Average weekly fortified wine intake 2.3 2.8 4.5 -2.0 -1.2 -2.1 -1.3 -2.0 0.8 -1.7
Maternal smoking around birth 0.9 1.3 4.1 -0.2 1.8 0.1 2.0 1.2 -0.3 -0.1
Fed-up feelings 1.8 3.3 5.4 1.5 1.9 1.9 2.2 2.3 -1.4 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.7 3.6 0.4 0.7 1.8 1.5 1.9 -0.1 1.4
Relative age voice broke 1.8 2.7 3.6 1.5 1.8 1.5 1.9 1.8 -1.5 1.4
Taking other prescription medications 3.9 6.0 10.0 2.2 1.7 2.2 2.1 3.2 -2.8 2.7
Age when periods started (menarche) 0.8 1.9 3.5 1.1 1.9 0.9 1.4 1.3 -1.1 1.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.9 0.2 1.0 -0.5 0.5 0.5 -0.9 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.2 -1.0 -2.0 -0.6 -1.5 -0.3 -0.9 0.4
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.2 -0.1 0.4 -0.1 0.2 0.1 -0.1 -0.0
Qualifications: CSEs or equivalent 1.7 2.3 7.6 1.7 -0.6 0.9 0.2 1.4 -1.5 2.8
Serious illness, injury or assault to yourself 0.3 0.4 1.9 1.4 -0.3 -0.3 0.3 0.6 -0.3 0.2
High blood pressure 0.4 1.1 2.6 -0.2 1.6 0.7 1.4 1.0 1.1 0.6
Hayfever, allergic rhinitis or eczema 1.9 4.1 6.9 2.0 1.7 1.0 2.3 2.6 -2.2 1.9
Multivitamins +/- minerals 1.1 1.4 3.0 1.0 1.2 0.6 0.9 1.7 -0.9 1.5
Stomach or abdominal pain in last month 0.8 0.9 2.6 1.1 0.5 1.6 1.5 0.4 0.1 0.3
Supplements: Glucosamine 4.7 6.2 9.1 2.3 2.7 2.2 2.3 3.0 -1.9 2.8
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 3.4 -1.0 1.8 1.1 1.6 0.2 1.2 -1.8
Medication: Atenolol 2.1 2.6 4.5 -2.1 -0.8 -2.1 -1.4 -1.5 2.0 -0.9
Medication: Levothyroxine sodium 1.1 1.8 2.7 1.5 0.7 1.2 1.2 1.6 -1.3 1.5
Sitting height 0.3 2.2 6.0 -1.2 -0.5 -2.5 -0.1 -1.7 1.1 -1.9
Chronic bronchitis/emphysema (father) 0.9 1.1 4.4 0.6 -1.1 -0.1 -0.6 0.8 -2.1 0.8
High blood pressure (mother) 0.8 1.1 1.9 -1.1 -1.1 1.1 -0.6 -0.8 1.0 -1.4
Body mass index (BMI) 1.7 7.3 16.2 2.2 1.6 1.7 2.4 4.0 -3.1 3.1
Impedance of leg (left) 1.2 5.8 15.1 -2.1 0.2 3.2 0.0 -2.6 3.9 -1.9
Leg predicted mass (left) 0.4 2.4 6.8 1.3 0.4 -1.4 1.2 1.7 -2.6 1.3
Trunk fat mass 1.0 4.3 7.5 1.3 1.6 2.7 2.5 2.6 -1.5 1.7
Waist circumference 1.7 6.0 10.5 1.4 2.2 3.2 2.8 3.1 -1.9 2.1
Number of incorrect matches in round 2.5 4.1 12.9 1.6 0.2 3.6 1.3 2.2 -1.2 2.3
Past tobacco smoking 1.4 2.6 5.6 -1.5 -1.9 -1.5 -1.1 -2.4 0.9 -1.6
Alcohol usually taken with meals 1.4 2.3 5.6 -1.2 -0.5 -1.4 -1.2 -2.1 2.4 -1.1
Nervous feelings 1.1 2.0 4.4 0.7 0.9 1.8 2.1 1.9 -0.7 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 0.9 0.9 -0.3 0.8 0.6 0.8 -1.0 0.6
Hearing difficulty/problems with background noise 0.6 1.0 1.8 1.0 1.0 0.8 0.9 1.0 -1.4 0.8
Hair/balding pattern: Pattern 2 0.1 0.1 0.4 0.1 -0.3 -0.0 -0.1 0.2 -0.5 0.6
Had menopause 0.4 0.5 1.4 -1.1 1.2 0.7 0.5 0.3 0.5 0.1
Had other major operations 1.1 1.3 2.4 -1.5 1.0 -0.8 0.4 -1.5 1.0 -1.3
Forced vital capacity (FVC) 0.6 2.2 5.1 2.2 -1.1 -0.5 0.2 1.1 -1.9 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.5 -1.8 -1.9 -0.5 -1.4 -0.6 -0.4 0.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 0.2 1.2 -0.3 0.4 0.3 1.1 0.0
Qualifications: None of the above 0.2 0.3 1.3 0.4 -0.8 -0.1 -0.2 0.4 0.0 1.1
Financial difficulties in last 2 years 0.6 0.9 3.4 -0.1 1.4 0.4 1.8 0.8 -0.1 0.3
Mouth/teeth dental problems 0.8 1.3 3.1 -0.4 -1.8 -0.2 -1.5 -1.4 0.8 -0.8
Heart attack 1.5 1.9 6.5 -1.6 0.7 0.5 0.3 -0.8 2.5 -1.5
Allergy 3.0 6.8 11.2 -2.0 -2.9 -1.8 -3.1 -3.4 2.2 -2.5
Pain all over the body in last month 0.2 0.2 0.5 0.6 -0.2 -0.7 0.1 -0.1 0.6 -0.1
Diabetes (self-reported) 1.1 1.7 4.7 0.6 1.1 2.2 1.9 1.2 -0.5 0.3
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.0 -1.0 -1.7 -0.5 -1.3 -0.2 -1.0 0.1
Medication: Ramipril 0.4 0.6 1.3 -0.5 0.2 -1.2 0.9 0.0 0.9 -0.7
Medication: Simvastatin 1.4 2.0 3.7 1.1 1.6 1.1 1.6 1.9 -0.2 1.8
Fluid intelligence score 0.9 1.9 4.8 -1.4 -0.6 -0.6 -1.6 -2.2 1.0 -1.5
Illnesses of siblings 2.7 3.7 9.2 -1.0 -2.3 -2.2 -3.0 -1.9 0.1 -1.4
Neuroticism score 1.3 2.8 5.0 1.3 1.4 1.7 2.0 2.2 -1.3 1.5
Weight 1.0 5.0 9.4 1.9 0.9 1.2 2.3 3.1 -2.9 2.5
Impedance of arm (right) 2.3 10.5 22.1 -3.3 -0.3 0.7 -1.0 -4.5 4.7 -4.4
Arm fat percentage (right) 1.0 4.0 8.1 1.3 1.6 2.4 2.3 2.8 -1.5 1.7
Trunk fat-free mass 1.1 6.3 14.2 2.8 0.3 -0.7 1.5 3.1 -3.8 3.2
Hip circumference 0.2 1.0 2.6 0.4 0.7 -0.2 1.6 1.4 -1.4 0.5
Time employed in main current job 0.3 0.3 1.3 0.2 -1.1 0.3 -0.0 0.3 -0.7 0.4
Alcohol intake versus 10 years previously 0.5 0.7 2.4 0.2 0.3 0.6 1.3 0.4 -1.6 0.5
Father’s age at death 0.1 0.2 0.6 -0.2 -0.8 -0.1 -0.6 -0.3 -0.3 0.1
Worrier / anxious feelings 0.1 0.3 0.8 0.0 -0.3 0.9 0.0 0.4 -0.0 0.9
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 6.8 0.5 1.4 2.6 1.7 1.8 -0.5 1.0
Falls in the last year 1.3 1.8 3.8 1.1 0.4 1.3 0.9 1.9 -1.2 1.9
Hair/balding pattern: Pattern 3 0.2 0.2 1.2 -0.2 -0.3 1.1 -0.4 -0.3 0.2 0.2
Number of live births 4.2 5.9 9.1 1.7 3.0 2.4 2.9 2.9 -1.4 2.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.2 2.6 1.3 -1.6 -1.0 -0.3 0.4 -1.1 1.2
Pulse rate 0.4 0.7 1.7 0.5 0.6 0.2 0.9 1.3 -0.2 1.3
Happiness 1.9 2.3 3.8 1.4 1.4 1.0 1.9 1.9 -1.0 1.7
Noisy workplace 0.9 1.2 3.6 0.8 0.2 -0.7 0.7 1.9 -0.9 1.4
Qualifications: A levels/AS levels or equivalent 0.7 1.4 2.5 -1.2 -0.8 1.2 -1.3 -1.3 0.8 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.7 -0.1 -0.4 -1.0 0.2 -1.1 0.6 -1.6
Mouth/teeth dental problems: Dentures 0.2 0.3 0.8 -0.5 -0.5 -0.9 -0.9 -0.4 0.2 -0.2
Asthma 3.9 7.7 11.9 2.2 3.5 2.1 3.2 3.3 -2.2 2.6
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 8.1 -0.2 2.8 1.3 1.5 -0.0 1.5 -0.6
Medication: Cholesterol lowering 0.8 1.2 3.2 1.3 0.4 0.6 0.8 1.8 -0.6 1.4
Depression (self-reported) 0.8 1.0 1.7 1.1 0.8 1.0 1.3 1.3 -0.2 0.8
Medication: Lansoprazole 0.6 0.7 1.4 0.9 0.3 1.1 0.4 0.9 -0.8 1.2
Prospective memory result 1.9 2.3 6.8 2.6 0.4 1.2 0.9 1.4 -1.7 1.5
Lung cancer (father) 0.8 0.9 3.9 1.2 0.4 2.0 0.3 0.6 -0.4 0.4
Illnesses of mother 0.4 0.5 0.9 0.8 -0.4 -0.6 -1.0 0.4 -0.6 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 4.2 0.6 -2.0 -1.2 -1.0 -0.2 -0.8 0.6
Pulse wave Arterial Stiffness index 0.3 0.4 1.8 -0.0 1.4 -0.2 0.7 0.6 0.2 -0.0
Impedance of arm (left) 2.1 9.8 21.5 -3.2 -0.1 1.0 -1.0 -4.2 4.6 -4.2
Arm fat mass (right) 1.4 5.7 11.4 1.6 1.8 2.0 2.7 3.4 -2.5 2.3
Trunk predicted mass 1.1 6.2 13.7 2.7 0.3 -0.6 1.5 3.1 -3.7 3.2
Standing height 0.0 0.4 1.3 -0.2 -0.9 -0.5 0.3 -1.1 -0.3 -0.4
Length of working week for main job 2.0 2.2 5.4 -1.8 1.0 -1.5 -0.4 -1.2 2.3 -1.4
Exposure to tobacco smoke at home 0.3 0.3 0.7 -0.8 0.7 0.4 0.8 0.2 -0.4 -0.4
Breastfed as a baby 0.6 0.8 1.7 1.0 0.7 0.8 -0.0 1.1 -1.3 0.5
Tense / ‘highly strung’ 0.2 0.3 0.8 0.4 0.3 0.4 0.9 0.5 -0.7 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 5.0 0.7 2.2 0.6 2.0 1.4 -0.9 -0.3
Hair/balding pattern: Pattern 4 0.8 1.8 2.7 -1.6 -0.5 -1.3 -1.6 -1.3 1.4 -1.4
Birth weight of first child 1.4 2.6 4.0 -1.8 -0.9 -2.0 -0.1 -2.0 1.4 -1.9
Peak expiratory flow (PEF) 0.3 0.8 2.8 0.9 -0.7 -1.7 -0.2 0.2 -0.4 1.0
Pulse wave reflection index 0.8 1.0 2.9 -0.3 0.5 -0.2 -0.5 -1.1 1.5 -1.7
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.5 0.1 0.3 -0.1 0.7 0.3 -0.4 -0.5
Loud music exposure frequency 1.0 1.1 3.4 -0.1 0.7 0.1 0.9 -1.0 1.9 -1.4
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.0 -1.1 -1.2 0.3 -1.7 -1.2 -0.2 -0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 0.2 -0.4 0.1 0.6 0.1 -0.9 -0.2
Blood clot in the leg (DVT) 0.3 0.4 1.0 -0.2 1.0 0.3 0.5 0.6 0.7 0.5
Medication: Paracetamol 0.8 1.3 2.2 1.4 1.3 0.7 1.1 1.5 -0.3 1.1
Headache pain in last month 1.8 3.1 10.8 1.5 1.5 3.3 1.5 1.6 -0.1 1.2
Medication for cholesterol, blood pressure or diabetes 1.3 2.1 5.5 -1.1 -0.4 -0.8 -1.2 -2.3 0.9 -2.2
Glaucoma (self-reported) 1.8 2.1 7.3 1.8 0.1 2.7 1.1 1.2 -0.3 1.1
Gout (self-reported) 0.6 0.8 2.7 1.0 -0.4 1.6 0.5 0.1 1.2 0.3
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 7.1 1.7 0.8 1.4 1.7 2.6 -2.7 2.5
Medication: Amlodipine 0.2 0.3 0.8 -0.3 -0.5 0.9 0.8 -0.1 0.3 0.1
Medication: Ventolin 100micrograms inhaler 3.4 4.3 6.6 2.2 1.7 1.1 1.9 2.4 -2.3 2.6
Birth weight 0.4 0.9 3.9 2.0 -0.3 0.3 -0.1 0.8 -1.0 0.8
Chronic bronchitis/emphysema (mother) 2.2 2.5 5.5 -1.2 2.3 0.7 2.2 -0.1 2.1 -1.2
High blood pressure (siblings) 1.3 1.9 4.6 0.2 1.9 1.3 2.1 1.4 0.2 1.0
Forced vital capacity (FVC), Best measure 0.3 1.1 1.9 1.2 -1.4 -0.7 -0.4 0.5 -1.4 1.2
Body fat percentage 1.1 4.4 11.0 1.0 1.7 3.3 2.4 2.5 -1.0 1.6
Leg fat percentage (right) 2.0 7.1 15.4 1.6 2.2 3.9 2.6 3.3 -1.7 2.4
Arm fat-free mass (right) 1.2 6.0 12.8 2.4 0.4 -0.2 1.5 3.1 -3.6 3.3
Exposure to tobacco smoke outside home 1.4 1.9 6.0 -1.7 0.2 -0.9 -0.4 -1.6 0.9 -2.5
Comparative body size at age 10 0.6 1.6 3.8 0.8 0.3 -0.2 1.9 1.6 -1.8 1.1
Number of full brothers 1.7 2.1 4.1 0.1 2.0 1.5 2.0 2.0 0.1 0.7
Worry too long after embarrassment 1.5 2.5 5.2 0.8 2.1 1.8 2.3 1.6 -1.0 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.4 0.2 0.4 0.4 0.1 1.2 -1.0 0.2
Wheeze or whistling in the chest in last year 6.0 10.7 17.0 3.5 2.2 4.1 3.0 3.8 -2.3 3.5
Number of children fathered 1.1 1.3 3.9 0.2 1.1 0.1 2.0 1.5 -1.2 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.7 -1.6 1.0 -1.0 -0.1 -0.6 1.6 -1.4
Age at first live birth 1.2 2.1 8.3 0.5 -2.9 -0.4 -2.2 -0.9 -0.6 -0.1
Pulse wave peak to peak time 0.4 0.5 2.2 0.0 -1.5 -0.1 -0.7 -0.7 -0.3 0.0
Health satisfaction 0.7 0.9 2.2 0.4 0.6 0.7 1.5 1.2 -1.3 -0.2
Shortness of breath walking on level ground 3.0 3.6 6.4 2.5 0.7 2.1 1.4 2.3 -1.3 2.2
Qualifications: College or University degree 0.7 2.4 5.8 -1.8 -1.5 0.6 -1.3 -2.4 0.9 -1.6
Eye problems/disorders: None of the above 0.9 1.0 2.6 -1.4 -1.3 -0.4 -1.6 -0.7 0.0 -0.0
Mouth/teeth dental problems: Loose teeth 1.2 1.5 4.0 0.5 2.0 -0.2 1.9 1.2 -1.0 0.2
Emphysema/chronic bronchitis 2.6 2.9 5.9 1.1 1.3 2.4 2.3 2.2 -0.7 1.0
Medication for pain relief, constipation, heartburn 1.0 1.8 6.7 -0.1 -2.6 -1.4 -1.4 -1.3 -0.2 -0.3
Neck or shoulder pain in last month 2.1 3.0 7.5 1.5 2.7 1.7 2.2 1.6 0.2 1.1
Medication: Blood pressure 0.4 0.8 2.3 0.4 0.0 0.5 0.8 1.3 0.6 1.5
Angina (self-reported) 1.0 1.4 4.2 -0.5 0.9 -1.0 -0.2 -1.1 2.0 -1.5
Migraine (self-reported) 0.2 0.2 0.7 0.2 0.0 -0.3 0.8 0.0 -0.7 -0.0
Medication: Ibuprofen 3.2 3.8 12.9 -0.4 3.6 2.0 2.2 0.1 2.0 -0.8
Medication: Allopurinol 1.2 1.6 5.0 1.3 1.1 2.2 1.2 0.9 1.0 0.4
Medication: Omeprazole 1.5 1.7 3.2 1.2 1.2 1.1 0.9 1.8 -1.5 1.4
Medication: Seretide 50 evohaler 3.9 4.5 7.7 2.7 0.4 2.2 1.1 2.8 -2.1 2.5
Mean time to correctly identify matches 1.6 3.0 10.1 1.1 0.2 3.2 1.7 1.8 -0.9 1.7
Heart disease (mother) 0.7 0.9 2.0 -1.4 0.3 -1.4 -0.0 -0.6 1.0 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 -0.5 0.7 -0.5 0.6 -0.4 0.5 -0.5
Whole body fat mass 1.2 4.9 9.2 1.4 1.7 2.4 2.6 3.0 -1.9 2.0
Leg fat mass (right) 1.4 5.6 10.5 1.8 1.6 2.5 2.3 3.2 -2.3 2.5
Arm predicted mass (right) 1.1 5.7 10.9 2.2 0.8 -0.3 2.0 3.1 -3.3 3.1
Pulse rate, automated reading 0.6 1.8 3.8 1.2 0.4 0.5 0.9 1.8 -1.9 1.7
Alcohol intake frequency. 0.3 0.7 1.6 -0.5 1.0 -0.4 1.0 -0.7 0.3 -1.2
Comparative height size at age 10 0.1 0.7 3.2 -0.5 -0.3 -1.8 0.3 -0.5 -0.9 -0.5
Number of full sisters 2.1 2.5 6.1 0.3 1.2 2.1 2.5 1.6 0.1 1.7
Suffer from ‘nerves’ 0.5 0.7 2.6 -0.3 0.7 1.0 1.6 0.9 0.1 -0.2
Overall health rating 2.5 5.4 11.2 1.2 2.8 2.5 3.3 2.7 -1.8 1.1
Chest pain or discomfort 0.2 0.3 1.6 0.1 -0.1 1.3 -0.6 -0.0 -0.1 0.6
Had major operations 0.3 0.3 1.7 -0.1 1.3 -0.0 0.6 0.3 0.2 -0.5
Age at last live birth 0.6 0.9 2.0 1.1 -0.4 1.4 0.8 0.7 -1.2 0.4
Family relationship satisfaction 1.1 1.3 2.0 0.5 1.3 1.3 1.4 1.4 -1.2 0.7
Leg pain on walking 0.9 1.2 2.3 0.3 1.4 0.8 1.5 1.3 -1.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 1.1 0.6 -0.2 -0.4 0.9 0.0 0.8
Commuting to job workplace: Car/motor vehicle 2.4 2.8 5.4 1.5 1.2 1.5 2.3 2.2 -1.3 1.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 1.1 -0.5 0.2 0.2 -0.4 -1.1 0.5 -0.1
Medication: Aspirin 0.7 0.9 3.4 -1.9 -0.0 -0.6 -0.4 -0.6 1.1 -0.9
Supplements: Vitamin C 0.7 0.9 1.8 0.9 0.6 0.7 0.4 0.8 -1.3 1.3
Knee pain experienced in last month 1.8 2.8 5.6 2.4 1.1 0.4 1.2 2.2 -2.3 1.1
Hypertension (Self-reported) 0.3 0.9 1.9 -0.3 1.2 0.6 1.0 0.8 1.4 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.6 0.5 -0.1 1.5 0.1 1.2 -0.3 1.6
Illnesses of father: Heart disease 0.4 0.5 2.0 -0.0 -0.2 0.8 0.4 0.7 -0.6 1.4
Illnesses of siblings: Diabetes 0.8 0.9 3.9 0.5 1.1 0.9 2.0 0.1 0.0 -0.6
Smoking status: Previous 1.2 1.8 3.6 1.1 1.1 1.6 0.6 1.9 -0.7 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.1 -0.2 -1.3 -1.1 -0.8 -1.4 1.1 -0.9
Whole body fat-free mass 0.8 4.8 11.4 2.3 0.3 -0.9 1.4 2.6 -3.4 2.7
Leg fat-free mass (right) 0.4 2.2 5.3 1.1 0.3 -1.9 1.1 1.5 -2.3 1.2
Arm fat percentage (left) 1.0 3.9 8.0 1.1 1.8 2.4 2.2 2.8 -1.4 1.6
Average weekly red wine intake 0.3 0.5 1.8 0.6 0.2 0.3 -0.2 0.9 -0.6 1.3
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.3 0.0 -0.6 -1.8 -1.5 -0.9 -1.1 -0.2
Mood swings 5.0 9.0 14.9 3.0 1.0 3.9 1.8 3.7 -3.0 3.5
Loneliness, isolation 2.5 3.4 8.6 1.1 2.9 1.8 2.7 1.7 -0.2 0.8
Long-standing illness, disability or infirmity 3.8 5.8 10.6 1.9 2.0 1.8 2.3 3.2 -2.8 2.5
Ever had bowel cancer screening 0.3 0.3 1.2 -0.3 0.9 -0.4 0.3 0.3 1.1 0.1
Diabetes diagnosed by doctor 0.3 0.6 1.8 0.4 0.5 1.3 1.2 0.6 0.1 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.8 -0.6 -0.6 -0.8 -0.4 -0.7 0.9 -0.1
Friendships satisfaction 0.7 0.8 2.3 0.0 1.2 1.5 1.1 0.7 -0.3 0.7
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.5 0.8 -0.5 0.7 -0.2 -0.4 -0.8
Commuting to job workplace: Walk 4.5 4.9 7.9 -1.9 -2.5 -0.8 -2.8 -2.6 2.2 -2.0
Eye problems/disorders: Cataract 0.3 0.3 0.9 0.5 0.4 0.6 0.3 0.5 -0.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.3 -0.4 0.6 0.9 0.1 0.3 -0.0 1.1
Medication for cholesterol 0.9 1.4 3.3 0.7 -1.8 -0.9 -1.0 -0.8 -1.8 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.8 -0.6 1.7 -0.1 0.6 -0.6 0.7 -0.8
Back pain experienced in last month 0.2 0.3 1.0 0.8 1.0 0.2 0.6 0.3 -0.1 0.2
Mineral and other dietary supplements 5.3 7.2 11.8 -3.0 -2.3 -2.0 -1.8 -3.2 2.7 -3.4
Breast cancer (self-reported) 2.5 3.0 10.8 -1.4 -1.0 -3.3 -1.3 -1.5 0.9 -1.5
Asthma (self-reported) 4.6 9.1 13.4 2.6 3.7 2.2 3.4 3.6 -2.3 3.0
Osteoporosis (self-reported) 1.6 2.0 4.6 0.4 -1.6 -1.5 -2.2 -1.5 -0.1 -1.3
Osteoarthritis (self-reported) 3.8 4.9 9.5 1.7 3.1 1.8 2.2 2.5 -1.4 2.2
Medication: Aspirin 0.6 0.8 3.2 -1.8 -0.0 -0.6 -0.5 -0.4 1.1 -0.7
Medication: Gliclazide 0.7 0.8 3.1 0.3 -1.1 -0.5 -0.9 0.1 -1.8 0.1
Illnesses of father: None of the above (group 1) 0.8 1.0 2.0 1.0 -1.2 -1.4 -1.1 -0.4 -0.9 0.0
Smoking status: Current 1.1 1.8 5.0 0.4 1.8 -0.8 2.2 1.8 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.5 -0.0 -1.1 -1.2 -1.1 -0.3 -0.3 0.4
Whole body water mass 0.8 4.7 11.2 2.3 0.2 -1.0 1.4 2.6 -3.3 2.6
Leg predicted mass (right) 0.4 2.1 5.2 1.1 0.3 -2.0 1.1 1.4 -2.3 1.1
Arm fat mass (left) 1.3 5.3 10.8 1.5 1.8 2.0 2.6 3.3 -2.3 2.3
Number of self-reported non-cancer illnesses 1.0 1.7 3.8 -0.3 1.3 2.0 1.4 1.6 -0.2 1.4
Average weekly champagne plus white wine intake 4.5 6.2 14.8 -2.2 -0.9 -1.0 -1.7 -3.2 3.9 -2.9
Miserableness 3.9 6.8 9.9 2.8 2.0 2.3 2.2 3.1 -2.9 2.8
Guilty feelings 0.7 1.0 2.9 -0.1 0.9 1.1 1.7 1.4 -0.7 -0.0
Wears glasses or contact lenses 0.6 0.6 3.0 -0.5 0.1 0.7 0.8 -0.3 0.2 -1.7
Ever taken oral contraceptive pill 1.9 2.1 6.2 0.7 1.8 1.3 2.5 1.5 -0.3 0.6
Hearing aid user 2.0 2.3 7.4 1.2 -1.7 0.2 -0.8 0.9 -2.7 1.6
Mother’s age at death 0.2 0.2 0.6 0.8 -0.0 0.3 0.3 0.3 0.1 0.7
Financial situation satisfaction 0.4 0.5 2.1 0.3 1.2 0.2 1.4 0.3 0.4 -0.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.1 1.0 -0.3 -1.0 0.1 0.8 0.5 0.6
Commuting to job workplace: Public transport 1.3 1.6 3.0 -1.1 -1.0 -1.1 -0.9 -1.7 1.3 -1.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.9 1.2 -0.2 1.7 0.9 0.6 -0.3 0.6
Medication: Blood pressure 0.8 1.6 3.0 -1.0 1.6 1.2 1.2 -0.2 1.7 -1.1
Pain type(s) experienced in last month: Hip pain 6.3 8.0 15.1 3.7 1.3 0.2 1.0 3.4 -3.9 3.6
Supplements: Fish oil (including cod liver oil) 5.8 7.5 13.5 2.9 1.5 2.6 1.5 3.0 -3.2 3.7
High cholesterol (Self-reported) 1.3 2.3 6.4 1.5 1.2 0.5 0.5 2.3 -0.7 2.5
Medication: Bendroflumethiazide 0.6 0.8 1.9 1.1 1.0 1.4 0.9 0.5 0.8 0.1
Medication: Paracetamol 0.8 1.2 3.6 0.6 1.9 0.9 1.3 1.0 0.7 0.7
Medication: Lisinopril 0.8 1.0 4.2 -0.6 2.1 0.3 0.7 0.9 1.1 0.3
Medication: Atorvastatin 0.1 0.1 0.7 -0.1 -0.2 0.1 0.0 0.8 -0.4 -0.1
Illnesses of father: High blood pressure 0.8 1.0 3.9 0.0 2.0 0.7 1.1 0.4 1.1 0.1
Alcohol drinker status: Never 1.0 1.2 3.3 -0.9 1.8 0.1 1.6 0.1 0.2 -1.3
Ever smoked 0.4 0.7 2.3 0.6 1.5 0.4 0.7 1.3 -0.0 0.3
Basal metabolic rate 0.8 4.5 10.0 2.1 0.5 -0.6 1.7 2.6 -3.2 2.5
Leg fat percentage (left) 2.1 7.6 14.0 1.8 2.4 3.7 2.9 3.5 -1.7 2.7
Arm fat-free mass (left) 1.3 6.7 12.9 2.6 0.6 0.1 2.1 3.3 -3.6 3.3
Number of operations (self-reported) 1.3 1.9 4.9 -1.2 1.0 -1.9 0.4 -1.5 0.3 -2.2
Average weekly beer plus cider intake 0.5 0.7 3.3 -0.1 -0.6 0.5 0.1 0.9 -1.8 0.6
Irritability 1.2 2.0 4.2 1.3 -0.2 0.7 0.5 2.0 -1.9 1.9
Risk taking 2.0 3.0 5.7 1.1 2.1 0.5 2.0 2.0 -2.4 1.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.0 0.0 0.1 -1.0 -0.2 -0.3 -0.5 -0.5
Fractured/broken bones in last 5 years 3.3 4.3 7.2 2.7 1.4 1.7 2.2 2.3 -1.4 2.5
Age started oral contraceptive pill 0.3 0.4 1.5 -0.6 0.3 1.2 0.6 0.4 0.2 0.4
Diastolic blood pressure, automated reading 0.3 0.9 2.5 -0.7 0.4 0.5 0.6 1.2 -1.6 1.1
Ever depressed for a whole week 1.5 1.8 6.2 1.1 2.5 0.5 1.9 1.1 -0.4 0.4
Unable to work because of sickness or disability 0.3 0.4 1.0 0.5 0.7 0.6 0.6 0.6 -1.0 0.4
Commuting to job workplace: Cycle 2.8 3.4 7.4 -1.7 -0.9 -0.1 -2.1 -2.7 1.9 -2.2
Myopia 0.3 0.4 1.7 0.4 -1.3 0.1 -0.5 -0.8 0.4 -0.3
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.2 1.0 -1.3 -0.3 -1.1 -0.4 -1.8 0.1
Cholesterol lowering medication 0.6 0.8 1.8 -0.2 1.3 1.1 0.5 1.3 0.3 1.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.6 0.2 1.0 0.9 0.5 1.2 -1.1 1.1
Pain experienced in last month 1.3 2.2 4.1 -2.0 -1.4 -1.2 -1.7 -1.4 1.3 -1.2
Supplements: Calcium 0.4 0.4 1.1 0.6 0.3 0.1 0.3 0.5 -1.1 1.0
Basal cell carcinoma (self-reported) 0.6 0.7 2.7 0.7 1.0 0.1 1.6 0.3 -0.5 0.5
Heart attack/myocardial infarction (self-reported) 1.0 1.3 5.1 -1.3 0.5 0.3 0.1 -0.6 2.3 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.0 -0.5 0.9 -0.1 0.3 0.3 1.0 0.2
Heart disease (siblings) 1.0 1.2 2.7 0.9 0.1 -0.1 0.7 1.5 -1.6 1.5
Alcohol drinker status: Previous 0.2 0.2 0.6 0.2 0.7 -0.1 0.7 0.3 0.5 -0.3
Pack years of smoking 0.2 0.3 1.1 0.3 -0.2 0.1 0.5 1.1 -0.6 0.1
Impedance of whole body 1.9 9.6 23.1 -3.1 -0.1 2.3 -0.5 -3.9 4.8 -3.6
Leg fat mass (left) 1.7 6.5 12.3 1.9 1.9 2.6 2.6 3.5 -2.3 2.7
Arm predicted mass (left) 1.1 5.5 10.5 2.3 0.6 -0.2 1.9 3.0 -3.2 3.0