Hub : Genes

CBX3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2760	0.0920	0.00900	0.013	NA	0.091	NA	0.134	0.13000	NA	0.0012	NA	9.1e-05
2	TCGA	Breast Invasive Carcinoma	0.0496	0.0288	0.00770	0.001	0.004	0.008	NA	0.000	0.16000	0.0520	0.0083	NA	4.1e-01
3	TCGA	Glioblastoma Multiforme	0.3280	0.1560	0.00870	0.010	0.020	0.033	NA	0.013	0.15000	0.0780	0.0360	NA	1.2e-01
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0380	0.0184	0.00024	0.030	0.020	0.023	NA	0.019	0.00021	0.0025	0.0012	NA	2.8e-03
5	TCGA	Lung Adenocarcinoma	0.0727	0.0427	0.00300	-0.002	0.017	0.019	NA	0.000	0.81000	0.0036	0.0022	NA	3.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	2.4	0.5	-0.0	0.8	1.6	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	0.1	-0.5	0.4	1.1	-1.3
Depressed Affect (Nagel 2018)	0.9	1.8	6.7	2.6	0.3	1.4	-0.1	0.4
Depression (Nagel 2018)	0.7	1.1	2.4	0.7	-1.3	1.0	-1.6	-0.1
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.4	-0.6	1.2	-2.1	2.3	1.8
Neuroticism (Nagel 2018)	1.2	2.9	7.0	2.6	1.1	1.3	1.6	1.5
Schizophrenia (2018)	0.2	0.5	1.9	-0.2	-0.6	0.2	0.1	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.4	2.8	-0.4	-0.7	-1.4	-1.7	-1.3
Worry (Nagel 2018)	1.0	2.2	5.8	2.4	0.8	0.5	0.8	1.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.8	1.4	-0.2	-0.5	0.5	0.6
Alzheimer’s Disease (in father)	1.4	1.5	5.2	0.9	0.6	0.1	2.3	1.1
Alzheimer’s Disease (including proxy)	2.2	3.2	8.2	0.8	1.5	-0.1	2.9	2.2
Crohns Disease (2017)	0.7	1.6	5.4	-0.9	1.0	-0.3	2.3	0.7
Irritable Bowel Disease (IBD)	3.6	8.6	16.3	-1.1	3.0	1.0	4.0	3.9
Ulcerative Colitis (UC)	5.5	10.4	26.0	-0.1	3.1	1.8	3.6	5.1
Major Depression (MDD)	0.4	0.5	1.2	0.1	-0.6	0.7	-1.1	-0.7
Reaction Time	0.5	0.9	3.3	0.9	0.5	1.8	0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	0.3	0.7	-1.3	1.1	0.6
Breast Cancer	0.5	1.3	2.0	1.4	-0.9	-1.3	-0.6	-1.3
Ovarian Cancer	0.8	1.1	4.2	-0.1	-1.0	-2.0	0.3	0.4
Prostate Cancer	0.3	0.5	0.8	0.6	0.5	-0.7	-0.9	-0.8
Age at First Birth	0.6	0.9	1.8	-0.9	-1.4	-0.8	0.5	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.8	1.7	-0.8	-0.2	-0.7	-0.9
Coronary Artery Disease (CAD)	2.4	2.9	7.7	2.8	-1.5	0.3	-2.1	-0.5
Crohns Disease (2012)	0.3	0.5	1.3	-1.2	0.3	-0.8	0.5	-0.5
Mean Putamen Volume	0.9	1.0	2.6	1.6	0.5	-1.2	0.1	0.9
Fasting Glucose	0.9	1.1	4.7	0.3	-0.6	-2.2	-0.6	-0.1
HbA1C	0.2	0.2	0.5	0.5	-0.4	0.4	0.4	0.7
HDL Cholesterol	2.7	4.5	8.5	-2.9	1.4	-0.4	2.4	2.5
LDL Cholesterol	0.3	0.4	0.9	-0.5	-1.0	-0.8	-0.4	-0.4
Lupus	0.5	0.8	1.9	0.2	1.4	-0.4	1.1	0.9
Neuroticism (2016)	0.6	0.8	3.4	-0.0	0.3	0.6	-0.2	1.9
Primary Biliary Cirrhosis	0.5	0.8	2.0	0.1	-0.9	-0.7	0.6	-1.4
Rheumatoid Arthritis	0.6	0.9	3.1	1.7	-0.0	-0.5	-0.2	-1.0
Schizophrenia (2014)	0.3	0.6	1.3	0.4	0.4	0.5	1.0	-1.2
Triglycerides	1.2	2.0	6.9	2.6	1.2	0.5	0.7	0.9
Type 2 Diabetes (T2D) (2012)	1.9	2.2	5.4	1.4	-1.2	-0.2	-2.3	-1.5
Ulcerative Colitis	2.2	3.2	6.5	-1.0	1.3	2.6	1.7	2.0
Blood Eosinophil Count	0.2	1.2	2.9	0.5	-0.5	0.9	-1.3	-1.7
Blood Platelet Count	0.0	0.3	0.7	-0.2	0.5	0.8	0.6	0.6
Blood Red Count	0.6	6.0	8.8	2.2	-2.7	1.6	-3.0	-2.5
Blood White Count	0.6	4.5	14.4	1.4	1.6	3.8	0.1	2.0
Heel T-Score	0.3	2.4	7.4	-2.7	-0.6	0.2	1.2	-1.7
BMI	0.3	1.7	4.8	2.2	-1.1	-0.2	-1.6	0.2
Height	0.6	11.2	13.4	-3.0	-3.1	-3.7	-3.3	-3.6
Waist Hip Ratio (WHR)	3.1	14.1	50.7	7.1	-0.4	-2.5	-3.6	-0.5
Systolic Blood Pressure	0.4	2.0	9.0	3.0	0.7	-0.2	-0.5	0.5
Smoking Status	0.8	1.8	4.5	0.9	-0.9	0.2	-1.7	-2.1
Allergy or Eczema	0.3	0.7	3.0	-0.4	0.4	0.4	-0.1	1.7
Cardiovascular Disease	0.8	2.8	8.5	2.9	0.1	-1.2	-2.0	0.1
Hypothyroidism (self reported)	0.3	0.7	1.8	0.5	-1.0	-0.1	-0.4	-1.4
Respiratory disease	0.3	0.6	1.6	1.2	-0.1	-0.9	-0.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	3.4	1.9	-0.2	-0.5	-0.5	-0.3
Lung FEV1/FVC ratio	0.5	2.3	8.8	3.0	-1.2	-0.8	-0.6	0.6
Lung FVC	0.0	0.2	1.0	0.2	1.0	-0.0	0.3	0.2
Neuroticism	0.6	1.4	5.4	2.3	0.8	0.5	0.6	0.5
Chronotype (morning person)	0.5	1.3	2.3	-0.2	-1.2	1.5	1.2	-1.0
Hair Pigment	0.1	1.5	6.0	-0.3	-0.8	-0.6	-0.7	-2.4
Tanning	0.1	1.5	3.1	-1.7	0.6	0.6	-1.3	-1.3
Hand grip strength (left)	0.2	0.4	0.8	0.4	0.6	-0.6	0.7	-0.9
Number of treatments/medications taken	2.7	4.9	13.4	3.7	-1.4	-0.4	-2.8	-1.1
Average weekly spirits intake	1.5	1.8	3.6	-0.7	-1.1	-1.6	-1.1	-1.9
Sensitivity / hurt feelings	1.9	3.2	11.0	0.6	1.7	-1.1	3.3	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.7	-0.1	0.2	-0.4	0.6
Hearing difficulty/problems: Yes	0.8	1.2	3.1	-0.1	0.4	1.8	1.4	0.8
Relative age of first facial hair	0.6	1.3	3.7	-1.1	-0.7	0.6	-0.8	-1.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	7.3	2.7	-1.2	-0.6	-1.0	-0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.8	-0.7	-1.2	0.4	-1.7	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.1	-0.6	-0.8	-1.0	-0.4
Systolic blood pressure, automated reading	0.5	1.5	5.6	2.4	-0.3	-1.1	-0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	0.2	0.8	1.2	1.3	1.1
Angina	0.5	0.7	1.8	1.3	1.0	0.3	-0.5	0.5
Medication for hormone replacement therapy	0.4	0.5	1.5	0.4	-0.0	-1.2	-0.8	-0.2
Vitamin and mineral supplements	0.3	0.5	1.0	-0.7	0.8	0.4	0.1	1.0
Supplements: Zinc	0.4	0.5	0.9	-0.9	-0.8	-0.5	-0.3	0.7
Medication: Co-codamol	0.8	0.9	3.5	0.4	-0.4	1.9	-0.7	0.6
Medication: Metformin	1.2	1.8	3.4	1.6	-0.6	-1.9	-1.5	-0.5
Diabetes (father)	0.4	0.4	1.3	-0.3	0.1	1.1	-0.8	0.4
Diabetes (mother)	0.9	1.1	4.9	2.2	0.1	-0.1	0.7	0.6
Severe depression (siblings)	1.2	1.4	4.0	0.5	-1.3	0.0	-0.9	-2.0
Pack years adult smoking proportion	0.6	0.9	2.8	-1.2	0.5	0.2	-1.7	0.4
Impedance of leg (right)	0.3	1.5	2.8	-1.5	-1.2	0.1	-1.7	-0.9
Leg fat-free mass (left)	0.1	0.4	0.8	0.4	-0.5	-0.8	-0.3	-0.9
Trunk fat percentage	0.2	1.0	4.6	0.4	-0.3	0.2	-2.1	0.2
Hand grip strength (right)	0.5	1.3	2.0	1.4	0.5	-0.7	1.4	-1.3
Townsend deprivation index at recruitment	1.9	2.7	5.9	0.9	2.4	-1.3	0.5	2.2
Current tobacco smoking	0.6	0.9	3.9	-0.4	-0.3	-0.1	-2.0	-0.7
Average weekly fortified wine intake	1.4	1.6	4.2	0.4	-2.0	-0.7	-0.5	-1.8
Maternal smoking around birth	1.8	2.6	5.7	-1.0	-1.7	2.4	-1.0	-1.7
Fed-up feelings	0.3	0.5	1.1	1.0	0.5	0.4	-0.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	1.1	0.8	0.6	-0.2	0.7
Relative age voice broke	0.7	1.1	2.6	-0.4	-1.2	0.9	-1.6	-0.9
Taking other prescription medications	1.6	2.5	5.9	2.4	-0.8	-0.3	-2.3	-0.7
Age when periods started (menarche)	0.5	1.3	5.8	-2.4	0.6	0.1	0.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	1.2	-0.6	-0.4	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.2	5.9	0.1	-0.3	0.2	0.5	-2.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.0	1.0	-0.7	0.5	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.1	0.1	-0.0	-0.0	1.0	1.1
Serious illness, injury or assault to yourself	2.3	2.8	5.6	1.1	-2.1	-1.2	-2.4	-1.2
High blood pressure	1.1	3.2	12.9	3.6	-0.2	0.0	-1.6	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.6	0.3	0.2	-0.9	0.8
Multivitamins +/- minerals	0.6	0.7	1.7	0.5	-1.3	-0.7	0.3	-1.0
Stomach or abdominal pain in last month	1.0	1.2	2.2	0.7	-1.1	-1.5	-1.5	0.5
Supplements: Glucosamine	1.2	1.6	3.2	0.7	-1.6	-1.8	-0.8	-0.9
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	10.4	0.0	0.1	-3.2	0.9	-0.1
Medication: Atenolol	0.5	0.7	1.5	0.2	0.5	-0.3	-1.2	1.1
Medication: Levothyroxine sodium	1.0	1.7	3.7	1.7	-1.9	-0.2	-0.9	-1.0
Sitting height	0.2	1.3	3.6	-0.1	-0.6	-1.9	-0.6	-1.5
Chronic bronchitis/emphysema (father)	0.5	0.6	2.4	0.2	-0.1	0.2	0.6	1.5
High blood pressure (mother)	0.2	0.3	0.6	-0.1	0.3	0.7	-0.3	0.8
Body mass index (BMI)	0.2	0.9	3.8	1.9	0.3	-0.1	-0.6	0.4
Impedance of leg (left)	0.4	1.8	6.0	-0.6	-1.4	-0.1	-2.5	-0.9
Leg predicted mass (left)	0.1	0.4	0.8	0.4	-0.6	-0.8	-0.4	-0.9
Trunk fat mass	0.3	1.1	4.7	0.6	-0.7	-0.1	-2.2	-0.3
Waist circumference	0.5	1.8	3.8	2.0	-0.6	-0.7	-1.9	-0.8
Number of incorrect matches in round	0.4	0.6	1.0	0.9	0.6	0.2	1.0	-0.9
Past tobacco smoking	0.1	0.1	0.3	0.5	-0.3	0.1	-0.4	0.5
Alcohol usually taken with meals	0.4	0.7	3.5	-0.1	-0.0	0.0	1.9	-0.3
Nervous feelings	0.9	1.8	3.1	1.3	1.3	0.5	1.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.4	1.2	0.5	0.6	-0.2	0.6
Hearing difficulty/problems with background noise	0.3	0.5	0.9	0.5	0.6	0.0	1.0	-1.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.4	0.8	0.5	-0.4	1.2	-0.6
Had menopause	1.4	1.8	4.3	-0.0	-0.9	-0.9	-1.7	-2.1
Had other major operations	0.3	0.4	1.2	-0.2	-0.3	-0.4	-1.1	-0.8
Forced vital capacity (FVC)	0.1	0.6	1.2	1.1	0.3	-0.1	0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	6.9	0.3	-1.4	-0.6	-0.7	-2.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	1.0	-0.7	-0.1	-0.3	-0.5
Qualifications: None of the above	0.7	1.5	4.4	1.7	0.2	0.2	-2.1	0.0
Financial difficulties in last 2 years	0.5	0.7	2.5	1.6	-0.3	0.8	-0.3	0.5
Mouth/teeth dental problems	0.8	1.2	3.6	-1.5	-0.1	-0.4	1.9	-0.0
Heart attack	0.1	0.2	0.8	-0.0	0.9	-0.1	0.2	-0.0
Allergy	0.2	0.4	1.2	-0.6	-0.3	0.2	1.1	-0.5
Pain all over the body in last month	1.4	1.5	3.4	0.8	1.2	1.1	-0.8	1.8
Diabetes (self-reported)	1.1	1.8	4.2	1.8	-0.4	-2.0	-0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.9	-0.5	-0.5	-0.3	0.3
Medication: Ramipril	1.4	1.9	6.4	2.5	0.3	-1.4	-0.6	-0.6
Medication: Simvastatin	0.6	0.8	2.3	0.5	-0.1	-1.5	-1.1	-0.5
Fluid intelligence score	0.5	1.1	2.1	0.3	1.3	-1.2	0.5	1.4
Illnesses of siblings	0.1	0.2	0.5	-0.7	-0.0	-0.3	-0.4	-0.5
Neuroticism score	0.6	1.2	3.3	1.8	1.1	0.1	1.0	0.8
Weight	0.1	0.7	1.5	0.7	-0.7	-0.6	-1.2	-0.9
Impedance of arm (right)	0.5	2.1	9.4	-3.1	0.2	0.8	-0.6	0.4
Arm fat percentage (right)	0.2	0.6	2.4	0.7	0.0	0.5	-1.6	0.2
Trunk fat-free mass	0.3	1.9	4.0	0.5	-1.6	-1.2	-1.0	-2.0
Hip circumference	0.3	1.3	5.7	-2.4	0.4	0.7	0.1	-0.3
Time employed in main current job	2.3	2.7	8.4	-2.9	1.4	0.8	1.6	0.0
Alcohol intake versus 10 years previously	0.8	1.2	2.8	1.1	-1.1	-1.7	-0.9	0.4
Father’s age at death	0.5	0.7	1.3	-0.9	-0.5	-1.1	-0.1	1.1
Worrier / anxious feelings	0.3	0.6	1.6	0.6	0.7	-0.8	0.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	1.1	0.8	0.3	-0.6	1.1
Falls in the last year	1.8	2.4	7.1	-0.2	-2.1	-0.6	-2.7	-0.5
Hair/balding pattern: Pattern 3	0.2	0.4	0.9	-0.5	1.0	-0.6	0.0	0.4
Number of live births	1.2	1.8	4.3	-0.5	-0.7	-2.1	-0.6	-1.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.0	2.0	-0.0	-0.5	0.9	-0.6
Pulse rate	0.3	0.4	1.5	-1.2	0.1	-0.3	-0.7	0.2
Happiness	0.6	0.8	1.1	0.7	1.1	-1.0	-0.2	-1.1
Noisy workplace	1.1	1.4	4.5	-1.3	0.1	2.1	0.8	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.6	-0.0	0.3	-0.1	1.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.5	-0.8	1.0	1.4	0.7	1.9
Mouth/teeth dental problems: Dentures	1.2	2.1	8.8	0.8	-0.9	0.1	-3.0	0.1
Asthma	0.4	0.7	2.0	1.4	-0.0	-1.0	-0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	4.8	1.6	1.2	1.2	2.2	1.7
Medication: Cholesterol lowering	0.4	0.6	1.4	0.8	0.7	-1.2	-0.7	0.4
Depression (self-reported)	0.8	0.9	2.5	1.2	-0.6	-0.4	-1.6	-0.4
Medication: Lansoprazole	1.0	1.1	3.0	1.7	-0.9	-0.0	-1.2	0.4
Prospective memory result	2.4	2.9	4.6	-1.3	-1.6	-2.1	-1.9	-1.5
Lung cancer (father)	0.6	0.7	2.5	-0.4	-0.6	0.5	0.1	-1.6
Illnesses of mother	1.0	1.2	3.9	-2.0	0.1	-0.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.6	1.6	-0.5	-1.0	0.5	-1.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.8	-1.2	0.5	-1.4	-0.6	0.0
Impedance of arm (left)	0.2	1.1	3.9	-2.0	0.0	1.2	-0.5	0.3
Arm fat mass (right)	0.1	0.5	1.6	0.9	-0.2	0.1	-1.2	-0.2
Trunk predicted mass	0.3	2.0	4.0	0.5	-1.7	-1.3	-1.1	-2.0
Standing height	0.5	4.7	7.7	-2.5	-2.3	-1.4	-1.5	-2.8
Length of working week for main job	0.9	1.0	2.2	0.3	-1.1	-1.5	-0.5	-1.0
Exposure to tobacco smoke at home	0.6	0.7	2.3	1.5	1.0	0.5	-0.1	0.1
Breastfed as a baby	1.4	1.8	4.9	-1.4	-0.8	-0.8	-0.8	-2.2
Tense / ‘highly strung’	2.2	3.7	7.7	0.8	2.0	2.0	1.4	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.9	1.4	-0.1	-0.4	-0.9	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	4.1	0.4	-0.5	0.4	-0.6	2.0
Birth weight of first child	1.1	2.0	5.0	1.8	-0.2	-0.4	-2.2	-1.2
Peak expiratory flow (PEF)	0.7	1.5	4.4	2.1	0.3	-0.3	1.7	0.1
Pulse wave reflection index	0.5	0.6	1.7	0.2	1.3	0.6	0.5	0.7
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.8	0.3	1.2	2.2	0.6	1.3
Loud music exposure frequency	1.2	1.3	4.8	2.2	-0.9	0.5	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.9	-0.8	1.4	-0.1	2.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.7	-0.9	-0.0	-0.9	-0.7
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.3	-0.0	1.0	0.4	-0.9
Medication: Paracetamol	0.5	0.8	2.0	0.5	1.1	0.1	0.7	1.4
Headache pain in last month	0.4	0.7	1.5	-1.0	-0.4	-0.4	-1.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.6	-1.4	-0.7	1.6	1.0	-0.1
Glaucoma (self-reported)	1.1	1.3	5.0	-2.2	-1.0	-0.5	-0.4	-0.1
Gout (self-reported)	0.3	0.4	0.8	-0.4	-0.8	-0.4	-0.4	-0.9
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.1	0.6	-1.3	-0.2	-0.2	-1.5
Medication: Amlodipine	2.0	2.8	7.2	2.7	-0.6	0.5	-2.4	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	-0.3	0.6	-0.5	0.5	-0.1
Birth weight	1.4	3.0	8.1	-2.3	-1.1	0.4	-0.7	-2.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.1	-1.2	0.5	1.8	0.8	0.1
High blood pressure (siblings)	0.8	1.2	2.6	0.8	0.6	1.0	1.6	1.1
Forced vital capacity (FVC), Best measure	0.2	0.6	2.0	0.6	-0.4	-0.4	0.4	-1.4
Body fat percentage	0.3	1.1	4.3	0.8	-0.5	0.2	-2.1	-0.0
Leg fat percentage (right)	0.3	0.9	2.7	1.1	-0.7	0.3	-1.6	-0.3
Arm fat-free mass (right)	0.3	1.3	1.8	0.9	-1.2	-1.4	-0.7	-1.3
Exposure to tobacco smoke outside home	0.6	0.8	2.2	1.5	1.3	-0.5	-0.3	-0.2
Comparative body size at age 10	1.3	3.5	12.1	3.5	-0.7	-2.1	-0.7	-0.0
Number of full brothers	0.7	0.9	2.6	0.8	1.6	0.6	0.2	1.0
Worry too long after embarrassment	0.6	1.0	1.9	0.7	0.2	1.4	0.8	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.7	-0.4	-0.9	-0.6	-0.5
Wheeze or whistling in the chest in last year	0.6	1.0	3.0	1.0	-0.2	-0.3	-1.0	1.7
Number of children fathered	0.5	0.5	1.1	0.2	-0.7	1.1	1.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.1	-1.8	-0.4	0.7	0.4	0.4
Age at first live birth	2.5	4.4	12.3	-2.2	1.0	3.5	2.0	0.3
Pulse wave peak to peak time	0.5	0.6	1.2	1.1	-0.8	1.1	0.2	-0.3
Health satisfaction	0.8	1.1	3.9	0.5	1.0	2.0	0.3	0.3
Shortness of breath walking on level ground	0.8	1.0	2.0	0.4	1.4	-0.6	1.4	0.7
Qualifications: College or University degree	0.5	1.5	4.3	-0.7	-0.1	-1.2	2.1	-1.0
Eye problems/disorders: None of the above	0.4	0.4	1.3	-0.4	0.6	-1.1	0.5	-0.1
Mouth/teeth dental problems: Loose teeth	2.4	2.9	7.2	0.3	0.9	2.2	1.3	2.7
Emphysema/chronic bronchitis	1.9	2.1	4.4	-1.3	2.1	1.4	0.3	1.7
Medication for pain relief, constipation, heartburn	0.9	1.5	6.3	-2.5	-0.3	-0.8	0.6	0.2
Neck or shoulder pain in last month	1.1	1.6	2.9	-1.7	-0.8	1.0	-0.8	-1.6
Medication: Blood pressure	0.7	1.2	4.1	2.0	1.2	-0.6	-0.4	-0.0
Angina (self-reported)	0.4	0.5	1.1	0.9	1.0	0.4	-0.3	0.7
Migraine (self-reported)	1.8	2.3	3.3	-0.9	-1.6	-1.3	-1.8	-1.7
Medication: Ibuprofen	2.4	2.9	7.1	1.7	1.0	1.3	2.7	1.4
Medication: Allopurinol	0.2	0.2	0.7	-0.2	-0.9	-0.3	-0.4	-0.5
Medication: Omeprazole	2.7	3.2	5.5	1.7	-1.8	-1.1	-1.8	-2.3
Medication: Seretide 50 evohaler	1.2	1.4	2.8	-0.7	-0.5	1.5	-1.1	1.7
Mean time to correctly identify matches	0.5	0.9	4.2	-0.2	0.3	2.0	0.3	0.5
Heart disease (mother)	1.0	1.2	1.7	1.3	-1.0	-0.7	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	9.1	0.2	-0.7	-3.0	-0.0	-1.7
Whole body fat mass	0.3	1.1	3.6	1.1	-0.7	-0.2	-1.9	-0.3
Leg fat mass (right)	0.3	1.0	2.4	1.4	-0.8	0.0	-1.5	-0.3
Arm predicted mass (right)	0.4	2.0	2.6	1.1	-1.6	-1.3	-1.2	-1.6
Pulse rate, automated reading	0.1	0.3	1.2	0.2	-0.5	0.1	-1.1	-0.0
Alcohol intake frequency.	0.7	1.6	4.0	1.2	-0.0	-0.4	-2.0	1.5
Comparative height size at age 10	0.4	2.2	5.7	-0.2	-1.0	-1.2	-1.7	-2.4
Number of full sisters	0.1	0.1	0.3	-0.3	0.1	-0.4	-0.1	-0.6
Suffer from ‘nerves’	0.7	1.1	3.0	1.7	1.0	-0.8	0.9	0.2
Overall health rating	1.3	2.7	9.1	3.0	0.8	-0.2	-1.7	1.1
Chest pain or discomfort	0.4	0.6	1.7	1.1	1.3	-0.2	-0.2	-0.0
Had major operations	0.8	1.0	2.2	1.4	-0.1	0.3	-1.5	-0.8
Age at last live birth	1.7	2.4	7.2	-2.7	0.4	1.6	1.4	-0.2
Family relationship satisfaction	0.5	0.6	1.6	0.2	-1.0	-0.4	-1.3	-0.4
Leg pain on walking	0.3	0.4	0.9	0.2	0.7	1.0	-0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	0.6	-0.3	0.2	0.1
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.8	1.5	-0.8	-1.0	-1.7	-0.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-1.1	-0.4	-0.8	0.3	-1.7
Medication: Aspirin	1.3	1.7	6.3	0.7	0.3	0.8	-2.5	-0.9
Supplements: Vitamin C	1.7	2.0	4.6	-1.1	2.1	0.6	1.7	0.9
Knee pain experienced in last month	0.4	0.7	1.0	-0.9	0.0	-0.9	-1.0	-1.0
Hypertension (Self-reported)	0.8	2.3	8.9	3.0	-0.3	-0.3	-1.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	3.2	1.8	-1.1	-1.0	-1.8	-0.7
Illnesses of father: Heart disease	1.0	1.4	3.5	1.1	-1.9	-0.3	-0.9	-1.2
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.4	0.1	1.1	1.0	0.2
Smoking status: Previous	0.3	0.5	1.9	-0.3	0.6	-0.3	1.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	0.4	-1.4	-0.0	-0.8	-0.4
Whole body fat-free mass	0.2	1.2	2.7	0.5	-1.2	-1.1	-0.8	-1.6
Leg fat-free mass (right)	0.1	0.6	0.9	0.8	-0.6	-0.8	-0.5	-1.0
Arm fat percentage (left)	0.2	0.9	2.2	1.4	-0.0	0.5	-1.5	0.4
Average weekly red wine intake	0.9	1.3	3.7	0.9	1.1	-0.3	1.9	0.7
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.7	-0.3	1.1	-0.9	1.6	1.7
Mood swings	0.6	1.1	4.9	2.2	-0.0	0.7	-0.0	-0.4
Loneliness, isolation	0.4	0.6	1.4	1.2	0.0	-0.6	-0.7	-0.9
Long-standing illness, disability or infirmity	1.1	1.8	5.9	2.4	-0.3	-1.0	-1.2	-0.7
Ever had bowel cancer screening	1.9	2.2	4.2	-0.6	-2.1	-2.0	-1.3	-0.9
Diabetes diagnosed by doctor	1.3	2.2	4.4	2.0	-0.8	-2.1	-0.8	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.8	-0.4	-1.5	-0.0	-0.4	-1.7
Friendships satisfaction	0.7	0.8	2.2	0.0	-0.3	0.8	-1.1	-1.5
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.3	0.5	-0.7	0.3	-0.1
Commuting to job workplace: Walk	1.3	1.4	3.9	2.0	-0.9	-0.6	-0.2	-1.3
Eye problems/disorders: Cataract	0.9	1.0	2.1	1.2	0.3	1.1	-1.4	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.7	0.4	1.3	-0.3	0.1	0.5
Medication for cholesterol	1.9	2.9	6.7	-2.2	1.2	0.9	2.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.0	0.3	-1.4	0.6	-1.1	-1.4
Back pain experienced in last month	1.2	1.8	6.8	2.6	-0.4	-0.3	-1.3	0.1
Mineral and other dietary supplements	1.5	2.1	3.6	-1.0	1.8	1.9	1.4	0.7
Breast cancer (self-reported)	0.5	0.6	2.6	0.1	-0.1	0.4	-1.6	0.4
Asthma (self-reported)	0.4	0.8	1.9	1.4	-0.1	-1.2	-0.8	-0.4
Osteoporosis (self-reported)	0.4	0.5	0.9	-1.0	0.9	-0.1	0.6	-0.4
Osteoarthritis (self-reported)	1.0	1.3	4.0	0.6	-1.1	0.9	-2.0	0.6
Medication: Aspirin	0.8	1.1	3.0	0.6	0.6	1.1	-1.7	-0.6
Medication: Gliclazide	2.0	2.2	4.9	2.2	1.8	0.3	1.1	1.4
Illnesses of father: None of the above (group 1)	0.9	1.1	3.0	-0.9	1.7	0.1	1.0	-0.6
Smoking status: Current	0.7	1.1	4.4	-0.5	-0.5	-0.2	-2.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	1.5	0.0	-0.7	0.2	-0.4
Whole body water mass	0.2	1.3	2.5	0.5	-1.2	-1.2	-0.9	-1.6
Leg predicted mass (right)	0.1	0.5	0.8	0.9	-0.6	-0.7	-0.6	-0.9
Arm fat mass (left)	0.1	0.6	1.4	1.1	-0.2	-0.0	-1.2	-0.0
Number of self-reported non-cancer illnesses	1.1	1.9	5.0	1.6	-0.9	-0.3	-2.2	-0.9
Average weekly champagne plus white wine intake	1.0	1.4	4.5	-2.1	1.1	-0.5	0.9	0.1
Miserableness	0.5	0.9	2.8	1.7	0.7	-0.8	0.7	-0.6
Guilty feelings	1.2	1.8	4.1	0.2	2.0	0.2	1.8	1.3
Wears glasses or contact lenses	1.2	1.4	3.6	0.9	-0.9	-0.2	-1.3	-1.9
Ever taken oral contraceptive pill	3.8	4.2	10.8	-0.6	-2.3	-1.1	-1.9	-3.3
Hearing aid user	1.9	2.1	4.8	0.2	-1.8	2.2	-1.5	-0.6
Mother’s age at death	1.0	1.3	3.2	-1.4	-1.8	-0.0	-0.5	-0.8
Financial situation satisfaction	1.0	1.3	2.2	0.6	1.5	1.3	1.4	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.8	0.0	0.6	0.1	1.4
Commuting to job workplace: Public transport	1.1	1.3	2.5	-1.6	-1.0	0.3	1.3	-1.1
Eye problems/disorders: Glaucoma	0.7	0.9	3.8	-1.9	-0.7	0.2	0.2	0.3
Medication: Blood pressure	1.5	2.9	11.6	3.4	-1.2	-0.0	-1.1	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.2	1.1	-0.2	0.7	-1.1	-0.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.9	0.6	-1.2	-1.7	-1.3	-1.3
High cholesterol (Self-reported)	0.9	1.5	5.5	0.4	-0.1	-2.4	-1.1	-0.9
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.3	-1.4	-0.1	-0.9	-0.2
Medication: Paracetamol	0.4	0.5	1.2	0.8	-0.0	1.1	0.0	1.0
Medication: Lisinopril	0.5	0.6	0.8	0.9	0.7	-0.7	0.8	0.9
Medication: Atorvastatin	1.1	1.3	3.6	1.9	-0.2	-0.8	-1.5	-0.1
Illnesses of father: High blood pressure	0.3	0.3	1.6	-0.2	-1.3	-0.3	-0.0	-0.1
Alcohol drinker status: Never	0.3	0.3	0.7	-0.9	-0.6	0.7	-0.2	0.0
Ever smoked	0.2	0.3	0.8	-0.5	0.1	-0.4	-0.5	-0.9
Basal metabolic rate	0.2	1.2	2.2	0.6	-1.1	-1.1	-1.0	-1.5
Leg fat percentage (left)	0.4	1.5	3.7	1.7	-0.7	0.3	-1.9	-0.3
Arm fat-free mass (left)	0.3	1.5	2.2	0.6	-1.2	-1.2	-1.4	-1.5
Number of operations (self-reported)	2.1	3.1	6.3	2.2	-1.1	-1.0	-2.5	-1.5
Average weekly beer plus cider intake	0.6	0.9	3.7	0.7	0.5	-1.9	-0.5	-0.0
Irritability	0.6	1.0	1.7	-0.4	1.3	1.2	1.2	0.5
Risk taking	0.6	0.8	2.5	0.5	-0.3	1.0	0.5	-1.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.3	2.1	-0.6	-0.5	-0.9	-0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-0.8	0.8	-1.2	0.5	-0.3
Age started oral contraceptive pill	0.2	0.2	0.5	-0.2	-0.2	-0.7	0.6	-0.3
Diastolic blood pressure, automated reading	0.2	0.7	3.2	1.8	0.4	-0.3	-0.2	-0.0
Ever depressed for a whole week	0.4	0.4	1.4	1.2	-0.3	-0.5	-0.6	0.2
Unable to work because of sickness or disability	1.5	1.9	4.2	2.1	1.4	0.8	-0.1	1.7
Commuting to job workplace: Cycle	0.7	0.9	2.8	-0.3	-0.7	0.4	0.9	-1.7
Myopia	2.6	3.8	7.9	1.1	-2.2	-2.8	0.0	-2.3
Vascular/heart problems diagnosed by doctor	1.3	3.4	13.2	-3.6	-0.1	0.0	1.8	-0.7
Cholesterol lowering medication	2.0	2.9	7.7	0.4	-1.7	-0.7	-2.8	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.2	1.8	-1.5	-1.1	-1.0	-1.6
Pain experienced in last month	0.4	0.6	2.1	0.2	0.5	0.8	1.4	-0.1
Supplements: Calcium	1.4	1.5	2.0	-1.2	-1.2	-1.3	-1.0	-1.4
Basal cell carcinoma (self-reported)	0.9	1.1	3.6	1.2	-0.5	-0.4	-1.9	-0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.3	-0.1	1.1	0.1	0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	-0.3	0.2	0.7	0.6	-0.8
Heart disease (siblings)	0.5	0.6	1.9	1.4	0.2	-0.2	-1.0	0.3
Alcohol drinker status: Previous	0.7	0.8	2.1	-1.2	0.4	-0.0	-0.6	1.4
Pack years of smoking	0.8	1.2	3.3	-1.5	0.2	0.2	-1.8	0.5
Impedance of whole body	0.2	1.1	3.5	-1.9	-0.4	0.6	-1.3	-0.2
Leg fat mass (left)	0.3	1.3	3.0	1.6	-0.7	0.0	-1.7	-0.2
Arm predicted mass (left)	0.3	1.6	3.0	0.3	-1.2	-1.4	-1.2	-1.7