Best TWAS P=2.98e-08 · Best GWAS P=2.42e-08 conditioned to 0.204
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | SYPL2 | 0.28 | 0.04 | lasso | 5 | 0.09 | 2.7e-03 | 4.8 | 5.1 | 3.0e-07 | 0.87 | 0.07 | 0.86 | FALSE |
2 | GTEx | Muscle Skeletal | CYB561D1 | 0.07 | 0.00 | lasso | 3 | 0.00 | 7.2e-01 | 5.2 | -5.2 | 1.7e-07 | -0.93 | 0.04 | 0.86 | FALSE |
3 | GTEx | Ovary | SYPL2 | 0.39 | 0.44 | lasso | 5 | 0.46 | 8.8e-13 | 5.2 | -5.2 | 2.4e-07 | -0.90 | 0.06 | 0.94 | FALSE |
4 | GTEx | Ovary | ATXN7L2 | 0.18 | 0.18 | enet | 17 | 0.13 | 5.6e-04 | 5.2 | -5.2 | 2.1e-07 | -0.92 | 0.05 | 0.89 | FALSE |
5 | GTEx | Testis | SYPL2 | 0.45 | 0.50 | enet | 22 | 0.54 | 5.0e-28 | 5.1 | -5.2 | 1.7e-07 | -0.94 | 0.05 | 0.94 | FALSE |
6 | GTEx | Testis | ATXN7L2 | 0.28 | 0.34 | lasso | 4 | 0.33 | 3.7e-15 | 5.1 | -5.1 | 2.7e-07 | -0.92 | 0.05 | 0.95 | FALSE |
7 | NTR | Blood | SORT1 | 0.05 | 0.06 | lasso | 6 | 0.06 | 2.1e-17 | 5.2 | 5.5 | 3.0e-08 | 0.91 | 0.04 | 0.96 | TRUE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SYPL2 | 0.03 | 0.05 | lasso | 4 | 0.05 | 6.6e-06 | 5.1 | 5.2 | 2.4e-07 | 0.92 | 0.02 | 0.98 | FALSE |