[Hub]/) : Traits : Verbal and Numeric Reasoning (VNR) :

chr2:72,774,203-74,604,895

Best TWAS P=4.6e-11 · Best GWAS P=8.3e-10 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ALMS1P 0.17 0.22 enet 18 0.23 1.6e-27 -4.7 -5.3 1.4e-07 0.16 0.58 0.42 FALSE
2 CommonMind Brain Pre-frontal Cortex FBXO41 0.08 0.03 blup 281 0.03 1.5e-04 -5.4 -6.6 4.6e-11 0.66 0.04 0.96 TRUE
3 GTEx Adipose Subcutaneous PRADC1 0.07 0.09 enet 3 0.09 1.1e-07 -5.5 5.6 2.1e-08 -0.68 0.04 0.96 FALSE
4 GTEx Artery Aorta PRADC1 0.21 0.09 enet 21 0.10 4.2e-06 -5.7 5.2 2.6e-07 -0.64 0.03 0.96 FALSE
5 GTEx Artery Tibial PRADC1 0.12 0.06 lasso 4 0.09 2.0e-07 -4.5 5.7 1.1e-08 -0.85 0.02 0.98 FALSE
6 GTEx Cells Transformed fibroblasts PRADC1 0.08 0.06 lasso 3 0.05 6.7e-05 -5.7 5.7 1.4e-08 -0.67 0.03 0.97 FALSE
7 GTEx Esophagus Mucosa PRADC1 0.13 0.04 enet 10 0.05 2.1e-04 -5.8 6.0 2.2e-09 -0.76 0.02 0.97 FALSE
8 GTEx Esophagus Muscularis PRADC1 0.20 0.14 enet 11 0.10 1.7e-06 -5.6 6.1 8.6e-10 -0.77 0.03 0.97 TRUE
9 GTEx Heart Atrial Appendage PRADC1 0.17 0.02 lasso 4 0.01 1.5e-01 -5.4 5.6 2.4e-08 -0.82 0.03 0.57 TRUE
10 GTEx Heart Left Ventricle PRADC1 0.16 0.09 enet 14 0.11 1.7e-06 -5.8 6.3 2.6e-10 -0.84 0.02 0.98 FALSE
11 GTEx Muscle Skeletal PRADC1 0.09 0.03 lasso 3 0.06 3.0e-06 -5.6 6.0 1.8e-09 -0.72 0.04 0.96 FALSE
12 GTEx Skin Sun Exposed Lower leg PRADC1 0.15 0.08 lasso 5 0.06 5.6e-06 -5.6 5.8 7.2e-09 -0.63 0.03 0.97 FALSE
13 ROSMAP Brain Pre-frontal Cortex PRADC1 0.23 0.19 lasso 3 0.21 5.6e-27 -4.5 5.3 1.1e-07 -0.65 0.18 0.81 FALSE
14 YFS Blood ALMS1 0.07 0.09 lasso 14 0.09 3.4e-29 -4.8 -5.2 2.6e-07 0.18 0.79 0.21 FALSE
15 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ALMS1P 0.16 0.10 enet 6 0.11 6.6e-06 -5.0 -5.5 3.5e-08 0.15 0.00 0.99 TRUE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C2orf7 0.02 0.01 blup 36 0.01 2.4e-02 -5.8 5.6 2.5e-08 -0.69 0.01 0.83 FALSE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ALMS1P 0.12 0.04 enet 7 0.06 2.6e-04 -4.9 -5.4 7.5e-08 0.13 0.01 0.94 FALSE
18 The Cancer Genome Atlas Brain Lower Grade Glioma NAT8 0.05 0.01 blup 30 0.03 2.5e-04 -4.9 -5.2 2.0e-07 0.14 0.01 0.98 FALSE
19 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ALMS1 0.03 0.01 blup 86 0.02 6.5e-03 -5.0 -5.2 2.4e-07 0.16 0.05 0.88 FALSE
20 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ALMS1P 0.21 0.11 blup 42 0.13 9.1e-06 -5.0 -5.2 1.7e-07 0.15 0.00 0.99 FALSE
21 The Cancer Genome Atlas Stomach Adenocarcinoma ALMS1 0.07 0.06 blup 92 0.04 5.7e-04 -5.3 -5.3 1.3e-07 0.18 0.03 0.94 TRUE
22 The Cancer Genome Atlas Stomach Adenocarcinoma C2orf7 0.03 0.03 lasso 2 0.03 4.7e-03 -5.4 5.4 5.4e-08 -0.69 0.01 0.87 FALSE