Best TWAS P=4.6e-11 · Best GWAS P=8.3e-10 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ALMS1P | 0.17 | 0.22 | enet | 18 | 0.23 | 1.6e-27 | -4.7 | -5.3 | 1.4e-07 | 0.16 | 0.58 | 0.42 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FBXO41 | 0.08 | 0.03 | blup | 281 | 0.03 | 1.5e-04 | -5.4 | -6.6 | 4.6e-11 | 0.66 | 0.04 | 0.96 | TRUE |
3 | GTEx | Adipose Subcutaneous | PRADC1 | 0.07 | 0.09 | enet | 3 | 0.09 | 1.1e-07 | -5.5 | 5.6 | 2.1e-08 | -0.68 | 0.04 | 0.96 | FALSE |
4 | GTEx | Artery Aorta | PRADC1 | 0.21 | 0.09 | enet | 21 | 0.10 | 4.2e-06 | -5.7 | 5.2 | 2.6e-07 | -0.64 | 0.03 | 0.96 | FALSE |
5 | GTEx | Artery Tibial | PRADC1 | 0.12 | 0.06 | lasso | 4 | 0.09 | 2.0e-07 | -4.5 | 5.7 | 1.1e-08 | -0.85 | 0.02 | 0.98 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PRADC1 | 0.08 | 0.06 | lasso | 3 | 0.05 | 6.7e-05 | -5.7 | 5.7 | 1.4e-08 | -0.67 | 0.03 | 0.97 | FALSE |
7 | GTEx | Esophagus Mucosa | PRADC1 | 0.13 | 0.04 | enet | 10 | 0.05 | 2.1e-04 | -5.8 | 6.0 | 2.2e-09 | -0.76 | 0.02 | 0.97 | FALSE |
8 | GTEx | Esophagus Muscularis | PRADC1 | 0.20 | 0.14 | enet | 11 | 0.10 | 1.7e-06 | -5.6 | 6.1 | 8.6e-10 | -0.77 | 0.03 | 0.97 | TRUE |
9 | GTEx | Heart Atrial Appendage | PRADC1 | 0.17 | 0.02 | lasso | 4 | 0.01 | 1.5e-01 | -5.4 | 5.6 | 2.4e-08 | -0.82 | 0.03 | 0.57 | TRUE |
10 | GTEx | Heart Left Ventricle | PRADC1 | 0.16 | 0.09 | enet | 14 | 0.11 | 1.7e-06 | -5.8 | 6.3 | 2.6e-10 | -0.84 | 0.02 | 0.98 | FALSE |
11 | GTEx | Muscle Skeletal | PRADC1 | 0.09 | 0.03 | lasso | 3 | 0.06 | 3.0e-06 | -5.6 | 6.0 | 1.8e-09 | -0.72 | 0.04 | 0.96 | FALSE |
12 | GTEx | Skin Sun Exposed Lower leg | PRADC1 | 0.15 | 0.08 | lasso | 5 | 0.06 | 5.6e-06 | -5.6 | 5.8 | 7.2e-09 | -0.63 | 0.03 | 0.97 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | PRADC1 | 0.23 | 0.19 | lasso | 3 | 0.21 | 5.6e-27 | -4.5 | 5.3 | 1.1e-07 | -0.65 | 0.18 | 0.81 | FALSE |
14 | YFS | Blood | ALMS1 | 0.07 | 0.09 | lasso | 14 | 0.09 | 3.4e-29 | -4.8 | -5.2 | 2.6e-07 | 0.18 | 0.79 | 0.21 | FALSE |
15 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ALMS1P | 0.16 | 0.10 | enet | 6 | 0.11 | 6.6e-06 | -5.0 | -5.5 | 3.5e-08 | 0.15 | 0.00 | 0.99 | TRUE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf7 | 0.02 | 0.01 | blup | 36 | 0.01 | 2.4e-02 | -5.8 | 5.6 | 2.5e-08 | -0.69 | 0.01 | 0.83 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ALMS1P | 0.12 | 0.04 | enet | 7 | 0.06 | 2.6e-04 | -4.9 | -5.4 | 7.5e-08 | 0.13 | 0.01 | 0.94 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NAT8 | 0.05 | 0.01 | blup | 30 | 0.03 | 2.5e-04 | -4.9 | -5.2 | 2.0e-07 | 0.14 | 0.01 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ALMS1 | 0.03 | 0.01 | blup | 86 | 0.02 | 6.5e-03 | -5.0 | -5.2 | 2.4e-07 | 0.16 | 0.05 | 0.88 | FALSE |
20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ALMS1P | 0.21 | 0.11 | blup | 42 | 0.13 | 9.1e-06 | -5.0 | -5.2 | 1.7e-07 | 0.15 | 0.00 | 0.99 | FALSE |
21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ALMS1 | 0.07 | 0.06 | blup | 92 | 0.04 | 5.7e-04 | -5.3 | -5.3 | 1.3e-07 | 0.18 | 0.03 | 0.94 | TRUE |
22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C2orf7 | 0.03 | 0.03 | lasso | 2 | 0.03 | 4.7e-03 | -5.4 | 5.4 | 5.4e-08 | -0.69 | 0.01 | 0.87 | FALSE |