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chr2:72,774,203-74,604,895

Best TWAS P=4.6e-11 · Best GWAS P=8.3e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	FBXO41	0.08	0.03	blup	281	0.03	1.5e-04	-5.4	-6.6	4.6e-11	0.66	0.04	0.96	TRUE
8	GTEx	Esophagus Muscularis	PRADC1	0.20	0.14	enet	11	0.10	1.7e-06	-5.6	6.1	8.6e-10	-0.77	0.03	0.97	TRUE
9	GTEx	Heart Atrial Appendage	PRADC1	0.17	0.02	lasso	4	0.01	1.5e-01	-5.4	5.6	2.4e-08	-0.82	0.03	0.57	TRUE
15	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ALMS1P	0.16	0.10	enet	6	0.11	6.6e-06	-5.0	-5.5	3.5e-08	0.15	0.00	0.99	TRUE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	ALMS1	0.07	0.06	blup	92	0.04	5.7e-04	-5.3	-5.3	1.3e-07	0.18	0.03	0.94	TRUE
10	GTEx	Heart Left Ventricle	PRADC1	0.16	0.09	enet	14	0.11	1.7e-06	-5.8	6.3	2.6e-10	-0.84	0.02	0.98	FALSE
11	GTEx	Muscle Skeletal	PRADC1	0.09	0.03	lasso	3	0.06	3.0e-06	-5.6	6.0	1.8e-09	-0.72	0.04	0.96	FALSE
7	GTEx	Esophagus Mucosa	PRADC1	0.13	0.04	enet	10	0.05	2.1e-04	-5.8	6.0	2.2e-09	-0.76	0.02	0.97	FALSE
12	GTEx	Skin Sun Exposed Lower leg	PRADC1	0.15	0.08	lasso	5	0.06	5.6e-06	-5.6	5.8	7.2e-09	-0.63	0.03	0.97	FALSE
5	GTEx	Artery Tibial	PRADC1	0.12	0.06	lasso	4	0.09	2.0e-07	-4.5	5.7	1.1e-08	-0.85	0.02	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	PRADC1	0.08	0.06	lasso	3	0.05	6.7e-05	-5.7	5.7	1.4e-08	-0.67	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	PRADC1	0.07	0.09	enet	3	0.09	1.1e-07	-5.5	5.6	2.1e-08	-0.68	0.04	0.96	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C2orf7	0.02	0.01	blup	36	0.01	2.4e-02	-5.8	5.6	2.5e-08	-0.69	0.01	0.83	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	C2orf7	0.03	0.03	lasso	2	0.03	4.7e-03	-5.4	5.4	5.4e-08	-0.69	0.01	0.87	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ALMS1P	0.12	0.04	enet	7	0.06	2.6e-04	-4.9	-5.4	7.5e-08	0.13	0.01	0.94	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	PRADC1	0.23	0.19	lasso	3	0.21	5.6e-27	-4.5	5.3	1.1e-07	-0.65	0.18	0.81	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ALMS1P	0.17	0.22	enet	18	0.23	1.6e-27	-4.7	-5.3	1.4e-07	0.16	0.58	0.42	FALSE
20	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALMS1P	0.21	0.11	blup	42	0.13	9.1e-06	-5.0	-5.2	1.7e-07	0.15	0.00	0.99	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	NAT8	0.05	0.01	blup	30	0.03	2.5e-04	-4.9	-5.2	2.0e-07	0.14	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ALMS1	0.03	0.01	blup	86	0.02	6.5e-03	-5.0	-5.2	2.4e-07	0.16	0.05	0.88	FALSE
4	GTEx	Artery Aorta	PRADC1	0.21	0.09	enet	21	0.10	4.2e-06	-5.7	5.2	2.6e-07	-0.64	0.03	0.96	FALSE
14	YFS	Blood	ALMS1	0.07	0.09	lasso	14	0.09	3.4e-29	-4.8	-5.2	2.6e-07	0.18	0.79	0.21	FALSE