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chr6:40,298,297-43,388,216

Best TWAS P=2.55e-13 · Best GWAS P=8.45e-15 conditioned to 0.0276

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ADCY10P1	0.34	0.25	enet	27	0.26	4.4e-21	4.9	6.2	4.1e-10	0.08	0.99	0.01	FALSE
2	GTEx	Adipose Visceral Omentum	NFYA	0.14	-0.01	enet	5	0.01	1.5e-01	4.9	5.3	1.5e-07	0.07	0.08	0.55	FALSE
3	GTEx	Adipose Visceral Omentum	ADCY10P1	0.28	0.27	lasso	7	0.27	3.3e-14	4.9	5.4	5.7e-08	0.07	0.99	0.01	FALSE
4	GTEx	Adrenal Gland	ADCY10P1	0.31	0.30	enet	21	0.26	6.9e-10	4.9	5.4	7.0e-08	0.07	0.97	0.02	FALSE
5	GTEx	Artery Coronary	ADCY10P1	0.31	0.11	enet	11	0.14	2.0e-05	4.9	5.4	5.4e-08	0.07	0.72	0.15	FALSE
6	GTEx	Breast Mammary Tissue	ADCY10P1	0.33	0.28	lasso	10	0.25	2.6e-13	4.9	5.2	1.9e-07	0.07	1.00	0.00	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ADCY10P1	0.33	0.01	lasso	11	0.03	5.1e-02	4.9	5.3	1.2e-07	0.06	0.09	0.17	FALSE
8	GTEx	Colon Sigmoid	ADCY10P1	0.29	0.14	lasso	12	0.22	3.8e-08	4.9	5.3	1.0e-07	0.06	0.28	0.66	FALSE
9	GTEx	Colon Transverse	ADCY10P1	0.14	0.09	lasso	5	0.11	4.5e-06	4.9	6.3	3.3e-10	0.06	0.15	0.84	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	ADCY10P1	0.31	0.21	lasso	9	0.16	1.6e-06	4.9	5.7	1.1e-08	0.07	0.24	0.74	FALSE
11	GTEx	Esophagus Muscularis	UBR2	0.12	0.04	lasso	5	0.05	4.0e-04	-4.5	5.9	3.2e-09	0.61	0.17	0.30	FALSE
12	GTEx	Esophagus Muscularis	PRPH2	0.11	0.00	lasso	11	0.00	6.1e-01	-6.0	-5.3	1.0e-07	-0.43	0.08	0.33	FALSE
13	GTEx	Lung	ADCY10P1	0.36	0.33	lasso	7	0.32	4.1e-25	4.9	5.2	1.7e-07	0.07	1.00	0.00	FALSE
14	GTEx	Ovary	ADCY10P1	0.42	0.29	enet	23	0.35	1.8e-09	4.9	6.0	2.0e-09	0.03	0.50	0.43	FALSE
15	GTEx	Skin Sun Exposed Lower leg	ADCY10P1	0.23	0.22	lasso	4	0.23	5.6e-19	4.9	5.4	7.1e-08	0.07	1.00	0.00	FALSE
16	GTEx	Spleen	ADCY10P1	0.48	0.31	lasso	11	0.28	8.4e-08	4.9	5.6	2.5e-08	0.05	0.45	0.49	FALSE
17	GTEx	Stomach	ADCY10P1	0.27	0.20	lasso	3	0.19	2.6e-09	4.9	5.8	7.8e-09	0.07	0.62	0.38	FALSE
18	GTEx	Testis	NFYA	0.21	0.16	enet	9	0.10	4.3e-05	6.5	6.3	2.6e-10	0.02	0.01	0.99	FALSE
19	GTEx	Testis	ADCY10P1	0.35	0.28	lasso	6	0.26	7.1e-12	4.9	5.3	1.2e-07	0.07	0.99	0.01	FALSE
20	GTEx	Thyroid	NFYA	0.36	0.34	lasso	9	0.36	1.1e-28	4.9	5.2	1.6e-07	0.07	1.00	0.00	FALSE
21	GTEx	Thyroid	ADCY10P1	0.41	0.37	enet	15	0.41	1.4e-33	4.9	5.7	1.3e-08	0.08	1.00	0.00	FALSE
22	GTEx	Vagina	ADCY10P1	0.64	0.43	lasso	14	0.43	5.0e-11	4.9	6.1	1.1e-09	0.07	0.27	0.72	FALSE
23	GTEx	Whole Blood	ADCY10P1	0.15	0.13	enet	13	0.17	3.2e-15	4.9	6.3	2.2e-10	0.08	0.90	0.10	FALSE
24	METSIM	Adipose	TFEB	0.08	0.03	lasso	5	0.03	4.6e-05	-4.2	-5.5	3.5e-08	-0.02	0.49	0.04	TRUE
25	METSIM	Adipose	UNC5CL	0.05	0.03	lasso	5	0.03	5.2e-05	6.7	6.5	8.8e-11	0.04	0.01	0.99	TRUE
26	ROSMAP	Brain Pre-frontal Cortex	TAF8	0.19	0.03	bslmm	442	0.09	5.4e-12	6.4	7.3	2.6e-13	0.26	0.91	0.06	TRUE
27	ROSMAP	Brain Pre-frontal Cortex	ADCY10P1	0.29	0.28	lasso	4	0.34	1.6e-45	4.9	6.5	1.1e-10	0.07	1.00	0.00	FALSE
28	YFS	Blood	TRERF1	0.06	0.01	bslmm	464	0.03	8.5e-11	7.4	7.0	2.0e-12	0.53	0.00	1.00	TRUE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC221442	0.07	0.08	blup	48	0.09	2.5e-08	4.8	5.3	1.5e-07	0.09	0.44	0.56	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC221442	0.05	0.05	blup	49	0.05	5.8e-10	4.2	5.2	2.3e-07	0.09	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC221442	0.08	0.10	lasso	6	0.09	4.9e-10	4.9	5.3	1.3e-07	0.07	0.99	0.01	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LOC221442	0.11	0.09	blup	48	0.12	2.2e-07	4.9	5.5	3.3e-08	0.08	0.33	0.67	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC221442	0.15	0.15	enet	12	0.18	5.8e-20	4.9	5.6	2.8e-08	0.08	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PRPH2	0.22	0.06	blup	50	0.09	4.4e-05	-3.8	-5.3	1.4e-07	-0.47	0.01	0.97	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC221442	0.05	0.03	blup	49	0.06	2.0e-07	4.9	6.3	3.1e-10	0.07	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC221442	0.02	0.02	lasso	5	0.02	1.9e-03	4.9	5.4	5.7e-08	0.07	0.13	0.46	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC221442	0.14	0.06	blup	49	0.06	2.4e-03	4.9	5.7	1.3e-08	0.08	0.07	0.36	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC221442	0.12	0.13	enet	6	0.14	1.1e-14	4.9	5.7	1.5e-08	0.08	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	LOC221442	0.06	0.02	blup	49	0.04	1.3e-03	4.9	6.2	6.0e-10	0.07	0.05	0.55	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	LOC221442	0.18	0.22	enet	10	0.24	2.4e-23	4.9	5.9	4.0e-09	0.08	1.00	0.00	FALSE