TWAS hub - TAF8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.392	0.1090	5.4e-03	0.088	NA	0.124	NA	0.103	0.00440	NA	8.0e-04	NA	2.1e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.190	0.0409	2.5e-06	0.033	0.075	0.084	0.093	0.067	0.00004	6.9e-10	5.7e-11	5.4e-12	4.8e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Atorvastatin	5.4	6.7	12.8	0.8	-3.6
Blood White Count	4.1	30.1	53.5	-2.6	7.3
Prospective memory result	3.8	4.7	7.5	-1.4	2.7
Medication: Ventolin 100micrograms inhaler	3.5	4.5	7.8	2.8	1.1
Multivitamins +/- minerals	3.3	4.2	5.5	1.7	-2.3
Coronary Artery Disease (CAD)	3.1	3.6	5.3	-2.3	1.4
Chronic bronchitis/emphysema (mother)	3.1	3.6	3.9	-2.0	-1.8
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	5.4	-1.5	-2.3
Supplements: Fish oil (including cod liver oil)	3.0	3.9	7.9	-0.0	-2.8
Fluid intelligence score	2.9	6.0	11.9	0.0	-3.5
Mineral and other dietary supplements	2.9	3.9	7.8	-0.1	2.8
Medication: Bendroflumethiazide	2.7	4.1	6.3	2.5	1.4
Number of children fathered	2.3	2.6	3.7	-1.2	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	4.0	2.0	1.2
Major Depression (MDD)	2.2	2.7	5.3	2.3	0.2
Supplements: Glucosamine	2.1	2.7	5.4	2.3	-0.1
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	4.0	1.6	-2.0
Comparative height size at age 10	2.1	11.6	20.8	-1.6	4.6
Blood Red Count	2.0	19.5	30.0	3.0	5.5
Pulse wave Arterial Stiffness index	2.0	2.3	4.5	-0.5	2.1
Pulse wave peak to peak time	2.0	2.3	4.1	0.8	-2.0
Alcohol intake frequency.	2.0	4.5	5.9	-1.8	2.4
Illnesses of father: None of the above (group 1)	2.0	2.5	3.7	1.1	1.9
Blood Eosinophil Count	1.9	14.5	15.8	4.0	-3.6
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	2.3	-1.5	-1.4
Exposure to tobacco smoke at home	1.9	2.2	3.8	-1.9	0.8
Alcohol drinker status: Never	1.8	2.2	4.0	-0.7	2.0
Ulcerative Colitis	1.7	2.4	4.6	0.4	2.1
Average weekly spirits intake	1.7	2.1	2.3	1.4	1.5
Hand grip strength (right)	1.7	4.7	9.3	3.1	0.0
Noisy workplace	1.7	2.1	2.8	-1.2	1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.8	5.5	-2.3	-0.2
Illnesses of father: High blood pressure	1.7	2.1	3.2	-1.0	-1.8
Depression (Nagel 2018)	1.6	2.3	4.6	-0.3	2.1
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.4	0.3	2.1
Supplements: Zinc	1.6	1.7	3.2	1.8	0.5
Diabetes (mother)	1.6	2.1	2.9	1.1	1.7
Basal cell carcinoma (self-reported)	1.6	1.9	2.6	1.1	1.6
Verbal and Numeric Reasoning (VNR)	1.5	3.5	7.0	0.2	-2.6
Vitamin and mineral supplements	1.5	2.0	3.9	-0.4	2.0
High blood pressure (mother)	1.5	2.0	2.4	1.6	1.3
LDL Cholesterol	1.4	2.2	4.4	2.1	0.2
Diabetes (father)	1.4	1.8	2.2	-1.5	-1.1
Maternal smoking around birth	1.4	2.0	3.4	-1.8	0.7
Gout (self-reported)	1.4	1.9	3.7	1.9	-0.2
Commuting to job workplace: Public transport	1.4	1.7	2.6	1.6	0.8
Alzheimer’s Disease (including proxy)	1.3	1.8	3.3	-1.8	0.6
Triglycerides	1.3	2.1	2.4	1.4	1.6
Blood Platelet Count	1.3	15.2	29.3	-1.1	5.4
Hand grip strength (left)	1.3	3.5	6.9	2.6	0.2
Time employed in main current job	1.3	1.5	2.7	-0.6	1.6
Eye problems/disorders: Cataract	1.3	1.5	3.0	1.7	0.2
Fractured/broken bones in last 5 years	1.3	1.7	2.9	-0.7	1.7
Bipolar Disorder (2018)	1.2	1.9	2.5	-1.2	-1.6
Medication: Metformin	1.2	1.7	2.9	-0.6	-1.7
Alcohol usually taken with meals	1.2	1.9	2.5	-1.6	-1.1
Intelligence (Savage-Jansen 2018)	1.1	3.3	4.8	1.4	-2.2
Crohns Disease (2012)	1.1	1.8	2.2	-1.5	1.2
Ever had hysterectomy (womb removed)	1.1	1.3	2.3	-0.5	1.5
Medication for hormone replacement therapy	1.1	1.3	2.3	-1.5	0.4
Pack years adult smoking proportion	1.1	1.7	3.4	-1.8	0.0
Nervous feelings	1.1	2.1	4.1	2.0	-0.3
Breastfed as a baby	1.1	1.3	1.8	0.9	-1.3
Tense / ‘highly strung’	1.1	1.8	3.0	1.7	-0.7
Medication: Seretide 50 evohaler	1.1	1.3	1.8	1.3	0.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	1.7	1.0	1.3
Eye problems/disorders: Glaucoma	1.1	1.3	2.7	-1.6	0.1
Medication: Blood pressure	1.1	2.1	3.1	1.8	1.1
Risk taking	1.1	1.6	1.9	1.4	-1.1
Alcohol drinker status: Previous	1.1	1.2	2.4	-1.6	0.3
Pack years of smoking	1.1	1.6	3.2	-1.8	0.3
Bipolar Disorder or Schizophrenia	1.0	2.6	3.7	-1.2	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.5	-0.1	1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.8	1.9	-0.9
Qualifications: None of the above	1.0	2.1	2.7	-1.2	1.6
Happiness	1.0	1.3	1.9	1.4	-0.8
Ever smoked	1.0	1.8	2.2	1.2	-1.5
Alzheimer’s Disease (in mother)	0.9	1.1	1.8	-1.3	0.7
Crohns Disease (2017)	0.9	2.0	2.7	-1.7	1.2
Systolic Blood Pressure	0.9	4.7	7.0	2.6	1.6
Severe depression (siblings)	0.9	1.0	1.4	-1.2	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.8	1.9	-0.5
Stomach or abdominal pain in last month	0.9	1.2	1.7	-0.8	-1.3
Pulse wave reflection index	0.9	1.2	1.8	-1.3	0.8
Leg pain on walking	0.9	1.2	2.2	-1.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.4	-1.2	-0.9
Diabetes diagnosed by doctor	0.9	1.5	3.0	-0.0	-1.7
Irritable Bowel Disease (IBD)	0.8	1.9	3.1	-0.8	1.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.1	1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.6	-0.8	-1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	0.9	0.9	0.9
Had menopause	0.8	1.0	1.3	-0.8	1.1
Hip circumference	0.8	3.3	4.0	-2.0	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	1.1	-0.9
Glaucoma (self-reported)	0.8	1.0	1.5	-1.2	-0.7
High blood pressure (siblings)	0.8	1.1	2.2	1.5	-0.2
Number of full brothers	0.8	1.0	1.0	-1.0	-1.0
Worry too long after embarrassment	0.8	1.3	1.8	0.9	-1.3
Eye problems/disorders: None of the above	0.8	0.9	0.9	-1.0	-1.0
Medication: Allopurinol	0.8	1.0	1.3	0.9	-1.1
Average weekly red wine intake	0.8	1.2	2.0	0.7	-1.4
Breast cancer (self-reported)	0.8	0.9	1.0	0.9	-1.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	-0.5	1.3
Irritability	0.8	1.4	2.7	1.6	0.3
Unable to work because of sickness or disability	0.8	1.0	1.2	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.0	-1.4	0.0
Alzheimer’s Disease (in father)	0.7	0.8	1.2	-1.1	-0.6
Ulcerative Colitis (UC)	0.7	1.3	2.5	0.4	1.6
Reaction Time	0.7	1.3	1.7	-1.3	0.9
Schizophrenia (2014)	0.7	1.5	2.8	-0.3	-1.7
Trunk fat percentage	0.7	2.9	5.0	-2.2	0.9
Financial difficulties in last 2 years	0.7	1.0	1.1	-1.0	-1.0
Mouth/teeth dental problems	0.7	1.0	2.0	1.4	-0.2
Medication: Simvastatin	0.7	1.0	1.9	-0.2	1.4
Worrier / anxious feelings	0.7	1.2	2.1	1.5	-0.6
Illnesses of mother	0.7	0.9	1.4	0.6	-1.2
Body fat percentage	0.7	2.6	4.6	-2.1	0.8
Leg fat percentage (right)	0.7	2.5	4.1	-2.0	1.0
Loneliness, isolation	0.7	1.0	1.3	0.8	1.2
Financial situation satisfaction	0.7	0.9	1.7	0.2	-1.3
Average weekly beer plus cider intake	0.7	1.0	2.0	1.4	-0.3
Diastolic blood pressure, automated reading	0.7	2.1	3.4	1.8	0.9
Cholesterol lowering medication	0.7	1.1	1.9	-0.5	1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.2	-0.7	-1.1
Neuroticism (Nagel 2018)	0.6	1.3	2.3	1.5	0.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	1.3	0.2
Mean Putamen Volume	0.6	0.7	0.9	-1.0	-0.7
Fasting Glucose	0.6	0.7	1.5	1.2	-0.1
Primary Biliary Cirrhosis	0.6	0.8	1.7	-1.3	0.0
Waist Hip Ratio (WHR)	0.6	2.9	3.4	1.6	1.8
Lung FVC	0.6	2.8	5.1	0.8	-2.3
Number of treatments/medications taken	0.6	1.1	1.8	1.4	-0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.2	-1.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.9	-1.0	-0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.4	-0.5	-1.2
High blood pressure	0.6	1.6	2.7	1.6	0.8
Sitting height	0.6	4.4	5.9	-1.7	2.4
Trunk fat mass	0.6	2.8	3.6	-1.9	1.4
Number of incorrect matches in round	0.6	0.9	1.9	0.1	1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	1.2	0.3
Impedance of arm (right)	0.6	2.7	4.2	-2.0	-1.1
Falls in the last year	0.6	0.9	1.0	-1.0	-0.9
Pulse rate	0.6	1.1	1.4	0.8	1.2
Medication: Lansoprazole	0.6	0.7	0.7	0.8	-0.8
Impedance of arm (left)	0.6	2.6	4.8	-2.2	-0.6
Birth weight of first child	0.6	1.2	1.3	1.0	-1.2
Arm fat-free mass (right)	0.6	3.3	6.6	0.3	2.6
Medication: Ibuprofen	0.6	0.7	1.3	1.1	-0.2
Mean time to correctly identify matches	0.6	1.1	1.5	-1.2	0.8
Arm predicted mass (right)	0.6	3.1	6.1	0.3	2.5
Age at last live birth	0.6	0.9	1.3	0.7	1.1
Hypertension (Self-reported)	0.6	1.6	2.7	1.6	0.7
Osteoporosis (self-reported)	0.6	0.7	1.3	-1.2	-0.3
Leg fat percentage (left)	0.6	2.2	3.4	-1.8	1.0
Ever depressed for a whole week	0.6	0.7	1.3	-0.2	-1.1
Pain experienced in last month	0.6	0.9	1.2	-0.8	-1.1
Arm predicted mass (left)	0.6	3.2	6.4	0.2	2.5
Schizophrenia (2018)	0.5	1.0	1.6	-0.6	-1.3
Height	0.5	9.6	16.1	-1.8	4.0
Cardiovascular Disease	0.5	1.7	3.4	1.9	-0.2
Hearing difficulty/problems: Yes	0.5	0.7	1.4	1.2	0.2
Waist circumference	0.5	1.9	3.3	-0.7	1.8
Medication: Ramipril	0.5	0.6	1.3	1.1	0.1
Weight	0.5	2.5	4.2	-0.9	2.1
Trunk fat-free mass	0.5	2.7	5.2	0.4	2.3
Trunk predicted mass	0.5	2.7	5.3	0.3	2.3
Length of working week for main job	0.5	0.6	1.0	-1.0	-0.3
Hair/balding pattern: Pattern 4	0.5	1.2	1.7	-1.3	0.8
Shortness of breath walking on level ground	0.5	0.5	0.9	0.4	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	-0.4	1.2
Whole body fat mass	0.5	2.1	2.4	-1.5	1.4
Suffer from ‘nerves’	0.5	0.7	1.5	-0.1	-1.2
Arm fat percentage (left)	0.5	1.8	3.1	-1.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.1	-1.1	-0.0
Wears glasses or contact lenses	0.5	0.5	0.6	-0.7	0.8
Arm fat-free mass (left)	0.5	2.8	5.5	0.2	2.4
Lung FEV1/FVC ratio	0.4	2.3	4.5	-2.1	0.1
Sensitivity / hurt feelings	0.4	0.7	1.1	1.0	-0.6
Systolic blood pressure, automated reading	0.4	1.1	1.1	1.1	1.0
Townsend deprivation index at recruitment	0.4	0.5	1.0	-1.0	-0.0
Fed-up feelings	0.4	0.6	0.9	0.6	1.0
Taking other prescription medications	0.4	0.6	1.3	-1.1	0.0
Age when periods started (menarche)	0.4	1.0	1.9	-0.2	-1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.5	-0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	1.0	0.2
Heart attack	0.4	0.5	0.6	-0.6	-0.8
Diabetes (self-reported)	0.4	0.6	1.1	-0.1	-1.1
Arm fat percentage (right)	0.4	1.6	2.9	-1.7	0.6
Standing height	0.4	3.5	6.9	-0.4	2.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	0.4	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	-0.4	-0.9
Heart disease (mother)	0.4	0.5	1.0	-1.0	0.2
Leg fat mass (right)	0.4	1.6	1.6	-1.3	1.3
Pulse rate, automated reading	0.4	1.3	2.3	0.5	1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.5	0.7	0.6
Whole body fat-free mass	0.4	2.4	4.6	0.5	2.1
Ever had bowel cancer screening	0.4	0.5	0.9	-0.3	-1.0
Whole body water mass	0.4	2.3	4.5	0.3	2.1
Arm fat mass (left)	0.4	1.7	2.1	-1.1	1.5
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.2	-0.9
Medication: Paracetamol	0.4	0.6	1.0	1.0	0.3
Medication: Lisinopril	0.4	0.5	1.1	-1.0	0.1
Basal metabolic rate	0.4	2.1	4.2	0.2	2.1
Impedance of whole body	0.4	2.1	4.2	-2.1	-0.2
Leg fat mass (left)	0.4	1.5	1.8	-1.1	1.3
Worry (Nagel 2018)	0.3	0.5	1.0	1.0	-0.4
Breast Cancer	0.3	0.8	1.4	-0.4	-1.2
HbA1C	0.3	0.3	0.5	-0.3	-0.7
HDL Cholesterol	0.3	0.5	1.0	0.0	-1.0
Lupus	0.3	0.5	0.9	0.9	0.2
Neuroticism (2016)	0.3	0.4	0.5	0.6	-0.7
Smoking Status	0.3	0.7	1.0	0.7	-1.0
Chronotype (morning person)	0.3	0.7	1.3	-1.1	0.3
Angina	0.3	0.4	0.7	-0.1	-0.9
Impedance of leg (right)	0.3	1.4	2.7	-1.6	-0.1
Current tobacco smoking	0.3	0.5	0.9	1.0	-0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.3	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.2	0.4	1.1
Medication: Levothyroxine sodium	0.3	0.5	0.8	0.3	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.1	0.8
Leg predicted mass (left)	0.3	1.4	2.8	0.2	1.7
Had other major operations	0.3	0.3	0.4	-0.6	-0.5
Allergy	0.3	0.7	1.3	-0.0	-1.1
Father’s age at death	0.3	0.4	0.5	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.8	0.6	-0.9
Arm fat mass (right)	0.3	1.3	1.5	-1.0	1.2
Loud music exposure frequency	0.3	0.4	0.4	-0.6	0.6
Health satisfaction	0.3	0.3	0.6	0.3	0.8
Medication: Blood pressure	0.3	0.6	0.9	0.5	-0.9
Angina (self-reported)	0.3	0.4	0.6	-0.4	-0.8
Migraine (self-reported)	0.3	0.4	0.5	0.7	0.6
Overall health rating	0.3	0.7	0.9	-0.9	-0.7
Had major operations	0.3	0.3	0.6	-0.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.1	-0.9
Illnesses of father: Heart disease	0.3	0.5	0.7	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.0	-0.4	1.0
Leg fat-free mass (right)	0.3	1.4	2.5	0.5	1.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.7	0.8	0.3
Commuting to job workplace: Walk	0.3	0.3	0.5	0.3	-0.7
Medication for cholesterol	0.3	0.5	1.0	-0.1	-1.0
Medication: Aspirin	0.3	0.4	0.6	-0.4	-0.8
Medication: Gliclazide	0.3	0.4	0.5	-0.7	-0.5
Leg predicted mass (right)	0.3	1.4	2.6	0.5	1.6
Miserableness	0.3	0.6	0.9	0.5	-1.0
Number of operations (self-reported)	0.3	0.5	0.9	-0.3	1.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.4	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.2	-1.1	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	-0.2	0.8
Rheumatoid Arthritis	0.2	0.3	0.6	0.8	-0.1
Heel T-Score	0.2	1.8	2.9	0.9	-1.7
Allergy or Eczema	0.2	0.4	0.8	-0.0	0.9
Relative age of first facial hair	0.2	0.5	0.5	0.7	-0.7
Leg fat-free mass (left)	0.2	1.3	2.6	0.3	1.6
Average weekly fortified wine intake	0.2	0.3	0.5	-0.3	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.1	0.7
Body mass index (BMI)	0.2	0.7	1.1	-0.7	1.0
Impedance of leg (left)	0.2	1.1	2.1	-1.5	-0.2
Past tobacco smoking	0.2	0.4	0.6	-0.3	0.8
Illnesses of siblings	0.2	0.2	0.4	0.1	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.3	-0.5	-0.5
Lung cancer (father)	0.2	0.2	0.3	0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.2	-0.4	0.5
Age at first live birth	0.2	0.3	0.6	0.8	0.2
Supplements: Vitamin C	0.2	0.2	0.4	-0.6	-0.2
Knee pain experienced in last month	0.2	0.3	0.6	0.3	0.8
Illnesses of siblings: Diabetes	0.2	0.3	0.4	-0.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.4	0.5
Back pain experienced in last month	0.2	0.2	0.4	0.6	-0.1
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	0.2	-0.9
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.2	0.7
High cholesterol (Self-reported)	0.2	0.4	0.8	0.0	0.9
Age started oral contraceptive pill	0.2	0.2	0.4	-0.2	0.6
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.3	-0.7
Myopia	0.2	0.2	0.4	0.2	0.6
Heart disease (siblings)	0.2	0.3	0.4	-0.7	0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	-0.2
BMI	0.1	0.7	1.1	-0.5	1.0
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	-0.1
Tanning	0.1	1.0	2.0	0.0	-1.4
Medication: Co-codamol	0.1	0.2	0.2	-0.4	-0.4
Serious illness, injury or assault to yourself	0.1	0.2	0.2	0.4	-0.4
Forced vital capacity (FVC)	0.1	0.2	0.4	0.7	-0.2
Pain all over the body in last month	0.1	0.1	0.2	0.2	0.4
Neuroticism score	0.1	0.2	0.4	0.3	-0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.5	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.4	0.5
Number of live births	0.1	0.1	0.1	0.3	0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.1	0.6
Asthma	0.1	0.2	0.2	-0.5	-0.3
Depression (self-reported)	0.1	0.1	0.3	-0.1	0.5
Peak expiratory flow (PEF)	0.1	0.3	0.5	0.0	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.1	-0.5
Medication: Paracetamol	0.1	0.2	0.4	0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.1	0.6
Birth weight	0.1	0.2	0.4	0.6	-0.0
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	1.0	-0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.4	0.1	-0.6
Comparative body size at age 10	0.1	0.3	0.5	-0.7	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.2	0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.5	-0.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.1	-0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.3	-0.4
Medication: Omeprazole	0.1	0.2	0.3	-0.6	-0.1
Number of full sisters	0.1	0.1	0.2	-0.4	-0.2
Chest pain or discomfort	0.1	0.2	0.3	0.5	-0.3
Medication: Aspirin	0.1	0.2	0.3	-0.2	-0.6
Mood swings	0.1	0.1	0.3	0.0	-0.5
Friendships satisfaction	0.1	0.1	0.1	-0.2	-0.3
Qualifications: nursing, teaching	0.1	0.1	0.1	-0.3	-0.4
Asthma (self-reported)	0.1	0.2	0.3	-0.5	-0.2
Smoking status: Current	0.1	0.1	0.2	0.5	-0.1
Mother’s age at death	0.1	0.1	0.2	-0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.0	-0.5
Ovarian Cancer	0.0	0.0	0.0	0.1	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.0	-0.0	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Respiratory disease	0.0	0.1	0.1	0.3	-0.2
Neuroticism	0.0	0.0	0.0	-0.2	-0.1
Hair Pigment	0.0	0.4	0.6	0.8	0.5
Relative age voice broke	0.0	0.0	0.0	-0.1	0.1
Medication: Atenolol	0.0	0.0	0.1	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	0.1	-0.3
Hearing difficulty/problems with background noise	0.0	0.0	0.0	-0.2	0.2
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	0.2	-0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	-0.1
Headache pain in last month	0.0	0.0	0.0	-0.1	-0.0
Medication: Amlodipine	0.0	0.1	0.1	-0.3	-0.2
Qualifications: College or University degree	0.0	0.1	0.1	0.3	0.1
Family relationship satisfaction	0.0	0.0	0.0	0.1	-0.1
Smoking status: Previous	0.0	0.0	0.0	0.0	-0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.1	-0.1	-0.3
Number of self-reported non-cancer illnesses	0.0	0.0	0.0	-0.2	-0.2
Guilty feelings	0.0	0.0	0.0	0.1	0.2
Hearing aid user	0.0	0.0	0.0	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.1	0.1
Supplements: Calcium	0.0	0.1	0.1	0.3	-0.1

Hub : Genes

TAF8

Models

Trait associations