Hub : Genes

TAF8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hypothalamus 0.392 0.1090 5.4e-03 0.088 NA 0.124 NA 0.103 0.00440 NA 8.0e-04 NA 2.1e-03
2 ROSMAP Brain Pre-frontal Cortex 0.190 0.0409 2.5e-06 0.033 0.075 0.084 0.093 0.067 0.00004 6.9e-10 5.7e-11 5.4e-12 4.8e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.2 1.9 2.5 -1.2 -1.6
Bipolar Disorder or Schizophrenia 1.0 2.6 3.7 -1.2 -1.9
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 -0.2 0.8
Depression (Nagel 2018) 1.6 2.3 4.6 -0.3 2.1
Intelligence (Savage-Jansen 2018) 1.1 3.3 4.8 1.4 -2.2
Neuroticism (Nagel 2018) 0.6 1.3 2.3 1.5 0.6
Schizophrenia (2018) 0.5 1.0 1.6 -0.6 -1.3
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.4 -0.2
Worry (Nagel 2018) 0.3 0.5 1.0 1.0 -0.4
Alzheimer’s Disease (in mother) 0.9 1.1 1.8 -1.3 0.7
Alzheimer’s Disease (in father) 0.7 0.8 1.2 -1.1 -0.6
Alzheimer’s Disease (including proxy) 1.3 1.8 3.3 -1.8 0.6
Crohns Disease (2017) 0.9 2.0 2.7 -1.7 1.2
Irritable Bowel Disease (IBD) 0.8 1.9 3.1 -0.8 1.8
Ulcerative Colitis (UC) 0.7 1.3 2.5 0.4 1.6
Major Depression (MDD) 2.2 2.7 5.3 2.3 0.2
Reaction Time 0.7 1.3 1.7 -1.3 0.9
Verbal and Numeric Reasoning (VNR) 1.5 3.5 7.0 0.2 -2.6
Breast Cancer 0.3 0.8 1.4 -0.4 -1.2
Ovarian Cancer 0.0 0.0 0.0 0.1 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.0 0.0 0.0 -0.0 -0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.6 1.3 0.2
Coronary Artery Disease (CAD) 3.1 3.6 5.3 -2.3 1.4
Crohns Disease (2012) 1.1 1.8 2.2 -1.5 1.2
Mean Putamen Volume 0.6 0.7 0.9 -1.0 -0.7
Fasting Glucose 0.6 0.7 1.5 1.2 -0.1
HbA1C 0.3 0.3 0.5 -0.3 -0.7
HDL Cholesterol 0.3 0.5 1.0 0.0 -1.0
LDL Cholesterol 1.4 2.2 4.4 2.1 0.2
Lupus 0.3 0.5 0.9 0.9 0.2
Neuroticism (2016) 0.3 0.4 0.5 0.6 -0.7
Primary Biliary Cirrhosis 0.6 0.8 1.7 -1.3 0.0
Rheumatoid Arthritis 0.2 0.3 0.6 0.8 -0.1
Schizophrenia (2014) 0.7 1.5 2.8 -0.3 -1.7
Triglycerides 1.3 2.1 2.4 1.4 1.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.1 1.0 -0.9
Ulcerative Colitis 1.7 2.4 4.6 0.4 2.1
Blood Eosinophil Count 1.9 14.5 15.8 4.0 -3.6
Blood Platelet Count 1.3 15.2 29.3 -1.1 5.4
Blood Red Count 2.0 19.5 30.0 3.0 5.5
Blood White Count 4.1 30.1 53.5 -2.6 7.3
Heel T-Score 0.2 1.8 2.9 0.9 -1.7
BMI 0.1 0.7 1.1 -0.5 1.0
Height 0.5 9.6 16.1 -1.8 4.0
Waist Hip Ratio (WHR) 0.6 2.9 3.4 1.6 1.8
Systolic Blood Pressure 0.9 4.7 7.0 2.6 1.6
Smoking Status 0.3 0.7 1.0 0.7 -1.0
Allergy or Eczema 0.2 0.4 0.8 -0.0 0.9
Cardiovascular Disease 0.5 1.7 3.4 1.9 -0.2
Hypothyroidism (self reported) 0.1 0.2 0.5 -0.7 -0.1
Respiratory disease 0.0 0.1 0.1 0.3 -0.2
Type 2 Diabetes (T2D) (2018) 0.8 1.6 2.6 -0.8 -1.6
Lung FEV1/FVC ratio 0.4 2.3 4.5 -2.1 0.1
Lung FVC 0.6 2.8 5.1 0.8 -2.3
Neuroticism 0.0 0.0 0.0 -0.2 -0.1
Chronotype (morning person) 0.3 0.7 1.3 -1.1 0.3
Hair Pigment 0.0 0.4 0.6 0.8 0.5
Tanning 0.1 1.0 2.0 0.0 -1.4
Hand grip strength (left) 1.3 3.5 6.9 2.6 0.2
Number of treatments/medications taken 0.6 1.1 1.8 1.4 -0.6
Average weekly spirits intake 1.7 2.1 2.3 1.4 1.5
Sensitivity / hurt feelings 0.4 0.7 1.1 1.0 -0.6
Frequency of depressed mood in last 2 weeks 1.6 2.3 4.4 0.3 2.1
Hearing difficulty/problems: Yes 0.5 0.7 1.4 1.2 0.2
Relative age of first facial hair 0.2 0.5 0.5 0.7 -0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.2 -1.1 -0.5
Ever used hormone-replacement therapy (HRT) 0.6 0.8 0.9 -1.0 -0.8
Ever had hysterectomy (womb removed) 1.1 1.3 2.3 -0.5 1.5
Systolic blood pressure, automated reading 0.4 1.1 1.1 1.1 1.0
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 0.9 0.9 0.9
Angina 0.3 0.4 0.7 -0.1 -0.9
Medication for hormone replacement therapy 1.1 1.3 2.3 -1.5 0.4
Vitamin and mineral supplements 1.5 2.0 3.9 -0.4 2.0
Supplements: Zinc 1.6 1.7 3.2 1.8 0.5
Medication: Co-codamol 0.1 0.2 0.2 -0.4 -0.4
Medication: Metformin 1.2 1.7 2.9 -0.6 -1.7
Diabetes (father) 1.4 1.8 2.2 -1.5 -1.1
Diabetes (mother) 1.6 2.1 2.9 1.1 1.7
Severe depression (siblings) 0.9 1.0 1.4 -1.2 0.8
Pack years adult smoking proportion 1.1 1.7 3.4 -1.8 0.0
Impedance of leg (right) 0.3 1.4 2.7 -1.6 -0.1
Leg fat-free mass (left) 0.2 1.3 2.6 0.3 1.6
Trunk fat percentage 0.7 2.9 5.0 -2.2 0.9
Hand grip strength (right) 1.7 4.7 9.3 3.1 0.0
Townsend deprivation index at recruitment 0.4 0.5 1.0 -1.0 -0.0
Current tobacco smoking 0.3 0.5 0.9 1.0 -0.1
Average weekly fortified wine intake 0.2 0.3 0.5 -0.3 -0.7
Maternal smoking around birth 1.4 2.0 3.4 -1.8 0.7
Fed-up feelings 0.4 0.6 0.9 0.6 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.5 -0.1 1.6
Relative age voice broke 0.0 0.0 0.0 -0.1 0.1
Taking other prescription medications 0.4 0.6 1.3 -1.1 0.0
Age when periods started (menarche) 0.4 1.0 1.9 -0.2 -1.4
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.5 0.1 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 3.8 1.9 -0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.3 0.8
Qualifications: CSEs or equivalent 0.6 0.8 1.4 -0.5 -1.2
Serious illness, injury or assault to yourself 0.1 0.2 0.2 0.4 -0.4
High blood pressure 0.6 1.6 2.7 1.6 0.8
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.2 0.4 1.1
Multivitamins +/- minerals 3.3 4.2 5.5 1.7 -2.3
Stomach or abdominal pain in last month 0.9 1.2 1.7 -0.8 -1.3
Supplements: Glucosamine 2.1 2.7 5.4 2.3 -0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.8 -0.5 -0.9
Medication: Atenolol 0.0 0.0 0.1 -0.1 -0.3
Medication: Levothyroxine sodium 0.3 0.5 0.8 0.3 0.9
Sitting height 0.6 4.4 5.9 -1.7 2.4
Chronic bronchitis/emphysema (father) 0.3 0.3 0.6 0.1 0.8
High blood pressure (mother) 1.5 2.0 2.4 1.6 1.3
Body mass index (BMI) 0.2 0.7 1.1 -0.7 1.0
Impedance of leg (left) 0.2 1.1 2.1 -1.5 -0.2
Leg predicted mass (left) 0.3 1.4 2.8 0.2 1.7
Trunk fat mass 0.6 2.8 3.6 -1.9 1.4
Waist circumference 0.5 1.9 3.3 -0.7 1.8
Number of incorrect matches in round 0.6 0.9 1.9 0.1 1.4
Past tobacco smoking 0.2 0.4 0.6 -0.3 0.8
Alcohol usually taken with meals 1.2 1.9 2.5 -1.6 -1.1
Nervous feelings 1.1 2.1 4.1 2.0 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 0.1 -0.3
Hearing difficulty/problems with background noise 0.0 0.0 0.0 -0.2 0.2
Hair/balding pattern: Pattern 2 0.0 0.1 0.1 -0.1 -0.3
Had menopause 0.8 1.0 1.3 -0.8 1.1
Had other major operations 0.3 0.3 0.4 -0.6 -0.5
Forced vital capacity (FVC) 0.1 0.2 0.4 0.7 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 3.8 1.9 -0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.0 1.0 0.2
Qualifications: None of the above 1.0 2.1 2.7 -1.2 1.6
Financial difficulties in last 2 years 0.7 1.0 1.1 -1.0 -1.0
Mouth/teeth dental problems 0.7 1.0 2.0 1.4 -0.2
Heart attack 0.4 0.5 0.6 -0.6 -0.8
Allergy 0.3 0.7 1.3 -0.0 -1.1
Pain all over the body in last month 0.1 0.1 0.2 0.2 0.4
Diabetes (self-reported) 0.4 0.6 1.1 -0.1 -1.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.5 1.2 0.3
Medication: Ramipril 0.5 0.6 1.3 1.1 0.1
Medication: Simvastatin 0.7 1.0 1.9 -0.2 1.4
Fluid intelligence score 2.9 6.0 11.9 0.0 -3.5
Illnesses of siblings 0.2 0.2 0.4 0.1 -0.6
Neuroticism score 0.1 0.2 0.4 0.3 -0.6
Weight 0.5 2.5 4.2 -0.9 2.1
Impedance of arm (right) 0.6 2.7 4.2 -2.0 -1.1
Arm fat percentage (right) 0.4 1.6 2.9 -1.7 0.6
Trunk fat-free mass 0.5 2.7 5.2 0.4 2.3
Hip circumference 0.8 3.3 4.0 -2.0 1.6
Time employed in main current job 1.3 1.5 2.7 -0.6 1.6
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.5 0.0
Father’s age at death 0.3 0.4 0.5 0.7 -0.5
Worrier / anxious feelings 0.7 1.2 2.1 1.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.1 0.2 -0.3
Falls in the last year 0.6 0.9 1.0 -1.0 -0.9
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 0.4 0.5
Number of live births 0.1 0.1 0.1 0.3 0.3
Forced expiratory volume in 1-second (FEV1) 0.0 0.0 0.0 0.1 0.1
Pulse rate 0.6 1.1 1.4 0.8 1.2
Happiness 1.0 1.3 1.9 1.4 -0.8
Noisy workplace 1.7 2.1 2.8 -1.2 1.7
Qualifications: A levels/AS levels or equivalent 0.3 0.6 0.8 0.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 2.3 -1.5 -1.4
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.1 0.6
Asthma 0.1 0.2 0.2 -0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.2 1.1 -0.9
Medication: Cholesterol lowering 0.2 0.3 0.3 -0.5 -0.5
Depression (self-reported) 0.1 0.1 0.3 -0.1 0.5
Medication: Lansoprazole 0.6 0.7 0.7 0.8 -0.8
Prospective memory result 3.8 4.7 7.5 -1.4 2.7
Lung cancer (father) 0.2 0.2 0.3 0.2 0.6
Illnesses of mother 0.7 0.9 1.4 0.6 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.1 0.3 -0.2
Pulse wave Arterial Stiffness index 2.0 2.3 4.5 -0.5 2.1
Impedance of arm (left) 0.6 2.6 4.8 -2.2 -0.6
Arm fat mass (right) 0.3 1.3 1.5 -1.0 1.2
Trunk predicted mass 0.5 2.7 5.3 0.3 2.3
Standing height 0.4 3.5 6.9 -0.4 2.6
Length of working week for main job 0.5 0.6 1.0 -1.0 -0.3
Exposure to tobacco smoke at home 1.9 2.2 3.8 -1.9 0.8
Breastfed as a baby 1.1 1.3 1.8 0.9 -1.3
Tense / ‘highly strung’ 1.1 1.8 3.0 1.7 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.0 0.2 -0.2
Hair/balding pattern: Pattern 4 0.5 1.2 1.7 -1.3 0.8
Birth weight of first child 0.6 1.2 1.3 1.0 -1.2
Peak expiratory flow (PEF) 0.1 0.3 0.5 0.0 0.7
Pulse wave reflection index 0.9 1.2 1.8 -1.3 0.8
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.3 -0.1
Loud music exposure frequency 0.3 0.4 0.4 -0.6 0.6
Qualifications: O levels/GCSEs or equivalent 2.1 3.4 4.0 1.6 -2.0
Mouth/teeth dental problems: Bleeding gums 3.0 3.9 5.4 -1.5 -2.3
Blood clot in the leg (DVT) 0.1 0.1 0.3 -0.1 -0.5
Medication: Paracetamol 0.1 0.2 0.4 0.6 -0.1
Headache pain in last month 0.0 0.0 0.0 -0.1 -0.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 0.4 1.1
Glaucoma (self-reported) 0.8 1.0 1.5 -1.2 -0.7
Gout (self-reported) 1.4 1.9 3.7 1.9 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 -0.1 0.6
Medication: Amlodipine 0.0 0.1 0.1 -0.3 -0.2
Medication: Ventolin 100micrograms inhaler 3.5 4.5 7.8 2.8 1.1
Birth weight 0.1 0.2 0.4 0.6 -0.0
Chronic bronchitis/emphysema (mother) 3.1 3.6 3.9 -2.0 -1.8
High blood pressure (siblings) 0.8 1.1 2.2 1.5 -0.2
Forced vital capacity (FVC), Best measure 0.1 0.5 0.9 1.0 -0.2
Body fat percentage 0.7 2.6 4.6 -2.1 0.8
Leg fat percentage (right) 0.7 2.5 4.1 -2.0 1.0
Arm fat-free mass (right) 0.6 3.3 6.6 0.3 2.6
Exposure to tobacco smoke outside home 0.1 0.2 0.4 0.1 -0.6
Comparative body size at age 10 0.1 0.3 0.5 -0.7 0.2
Number of full brothers 0.8 1.0 1.0 -1.0 -1.0
Worry too long after embarrassment 0.8 1.3 1.8 0.9 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.8 -0.4 -0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.2 0.4 0.5
Number of children fathered 2.3 2.6 3.7 -1.2 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.2 -0.4 0.5
Age at first live birth 0.2 0.3 0.6 0.8 0.2
Pulse wave peak to peak time 2.0 2.3 4.1 0.8 -2.0
Health satisfaction 0.3 0.3 0.6 0.3 0.8
Shortness of breath walking on level ground 0.5 0.5 0.9 0.4 1.0
Qualifications: College or University degree 0.0 0.1 0.1 0.3 0.1
Eye problems/disorders: None of the above 0.8 0.9 0.9 -1.0 -1.0
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.3 -0.5 -0.3
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.1 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 1.5 -0.4 1.2
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.3 -0.4
Medication: Blood pressure 0.3 0.6 0.9 0.5 -0.9
Angina (self-reported) 0.3 0.4 0.6 -0.4 -0.8
Migraine (self-reported) 0.3 0.4 0.5 0.7 0.6
Medication: Ibuprofen 0.6 0.7 1.3 1.1 -0.2
Medication: Allopurinol 0.8 1.0 1.3 0.9 -1.1
Medication: Omeprazole 0.1 0.2 0.3 -0.6 -0.1
Medication: Seretide 50 evohaler 1.1 1.3 1.8 1.3 0.9
Mean time to correctly identify matches 0.6 1.1 1.5 -1.2 0.8
Heart disease (mother) 0.4 0.5 1.0 -1.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 4.0 2.0 1.2
Whole body fat mass 0.5 2.1 2.4 -1.5 1.4
Leg fat mass (right) 0.4 1.6 1.6 -1.3 1.3
Arm predicted mass (right) 0.6 3.1 6.1 0.3 2.5
Pulse rate, automated reading 0.4 1.3 2.3 0.5 1.5
Alcohol intake frequency. 2.0 4.5 5.9 -1.8 2.4
Comparative height size at age 10 2.1 11.6 20.8 -1.6 4.6
Number of full sisters 0.1 0.1 0.2 -0.4 -0.2
Suffer from ‘nerves’ 0.5 0.7 1.5 -0.1 -1.2
Overall health rating 0.3 0.7 0.9 -0.9 -0.7
Chest pain or discomfort 0.1 0.2 0.3 0.5 -0.3
Had major operations 0.3 0.3 0.6 -0.2 0.8
Age at last live birth 0.6 0.9 1.3 0.7 1.1
Family relationship satisfaction 0.0 0.0 0.0 0.1 -0.1
Leg pain on walking 0.9 1.2 2.2 -1.5 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.4 -1.2 -0.9
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.5 0.7 0.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 1.7 1.0 1.3
Medication: Aspirin 0.1 0.2 0.3 -0.2 -0.6
Supplements: Vitamin C 0.2 0.2 0.4 -0.6 -0.2
Knee pain experienced in last month 0.2 0.3 0.6 0.3 0.8
Hypertension (Self-reported) 0.6 1.6 2.7 1.6 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.8 0.1 -0.9
Illnesses of father: Heart disease 0.3 0.5 0.7 -0.4 -0.9
Illnesses of siblings: Diabetes 0.2 0.3 0.4 -0.4 0.6
Smoking status: Previous 0.0 0.0 0.0 0.0 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.0 -0.4 1.0
Whole body fat-free mass 0.4 2.4 4.6 0.5 2.1
Leg fat-free mass (right) 0.3 1.4 2.5 0.5 1.6
Arm fat percentage (left) 0.5 1.8 3.1 -1.8 0.7
Average weekly red wine intake 0.8 1.2 2.0 0.7 -1.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.7 0.8 0.3
Mood swings 0.1 0.1 0.3 0.0 -0.5
Loneliness, isolation 0.7 1.0 1.3 0.8 1.2
Long-standing illness, disability or infirmity 0.0 0.1 0.1 -0.1 -0.3
Ever had bowel cancer screening 0.4 0.5 0.9 -0.3 -1.0
Diabetes diagnosed by doctor 0.9 1.5 3.0 -0.0 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.1 -1.1 -0.0
Friendships satisfaction 0.1 0.1 0.1 -0.2 -0.3
Qualifications: nursing, teaching 0.1 0.1 0.1 -0.3 -0.4
Commuting to job workplace: Walk 0.3 0.3 0.5 0.3 -0.7
Eye problems/disorders: Cataract 1.3 1.5 3.0 1.7 0.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.8 5.5 -2.3 -0.2
Medication for cholesterol 0.3 0.5 1.0 -0.1 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 -0.4 0.5
Back pain experienced in last month 0.2 0.2 0.4 0.6 -0.1
Mineral and other dietary supplements 2.9 3.9 7.8 -0.1 2.8
Breast cancer (self-reported) 0.8 0.9 1.0 0.9 -1.0
Asthma (self-reported) 0.1 0.2 0.3 -0.5 -0.2
Osteoporosis (self-reported) 0.6 0.7 1.3 -1.2 -0.3
Osteoarthritis (self-reported) 0.2 0.2 0.3 -0.4 0.5
Medication: Aspirin 0.3 0.4 0.6 -0.4 -0.8
Medication: Gliclazide 0.3 0.4 0.5 -0.7 -0.5
Illnesses of father: None of the above (group 1) 2.0 2.5 3.7 1.1 1.9
Smoking status: Current 0.1 0.1 0.2 0.5 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.9 0.2 -0.9
Whole body water mass 0.4 2.3 4.5 0.3 2.1
Leg predicted mass (right) 0.3 1.4 2.6 0.5 1.6
Arm fat mass (left) 0.4 1.7 2.1 -1.1 1.5
Number of self-reported non-cancer illnesses 0.0 0.0 0.0 -0.2 -0.2
Average weekly champagne plus white wine intake 0.2 0.3 0.5 0.2 0.7
Miserableness 0.3 0.6 0.9 0.5 -1.0
Guilty feelings 0.0 0.0 0.0 0.1 0.2
Wears glasses or contact lenses 0.5 0.5 0.6 -0.7 0.8
Ever taken oral contraceptive pill 0.4 0.4 0.8 -0.2 -0.9
Hearing aid user 0.0 0.0 0.0 0.1 -0.1
Mother’s age at death 0.1 0.1 0.2 -0.4 -0.0
Financial situation satisfaction 0.7 0.9 1.7 0.2 -1.3
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 0.1 0.1
Commuting to job workplace: Public transport 1.4 1.7 2.6 1.6 0.8
Eye problems/disorders: Glaucoma 1.1 1.3 2.7 -1.6 0.1
Medication: Blood pressure 1.1 2.1 3.1 1.8 1.1
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.8 -0.5 1.3
Supplements: Fish oil (including cod liver oil) 3.0 3.9 7.9 -0.0 -2.8
High cholesterol (Self-reported) 0.2 0.4 0.8 0.0 0.9
Medication: Bendroflumethiazide 2.7 4.1 6.3 2.5 1.4
Medication: Paracetamol 0.4 0.6 1.0 1.0 0.3
Medication: Lisinopril 0.4 0.5 1.1 -1.0 0.1
Medication: Atorvastatin 5.4 6.7 12.8 0.8 -3.6
Illnesses of father: High blood pressure 1.7 2.1 3.2 -1.0 -1.8
Alcohol drinker status: Never 1.8 2.2 4.0 -0.7 2.0
Ever smoked 1.0 1.8 2.2 1.2 -1.5
Basal metabolic rate 0.4 2.1 4.2 0.2 2.1
Leg fat percentage (left) 0.6 2.2 3.4 -1.8 1.0
Arm fat-free mass (left) 0.5 2.8 5.5 0.2 2.4
Number of operations (self-reported) 0.3 0.5 0.9 -0.3 1.0
Average weekly beer plus cider intake 0.7 1.0 2.0 1.4 -0.3
Irritability 0.8 1.4 2.7 1.6 0.3
Risk taking 1.1 1.6 1.9 1.4 -1.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.6 0.4 0.8
Fractured/broken bones in last 5 years 1.3 1.7 2.9 -0.7 1.7
Age started oral contraceptive pill 0.2 0.2 0.4 -0.2 0.6
Diastolic blood pressure, automated reading 0.7 2.1 3.4 1.8 0.9
Ever depressed for a whole week 0.6 0.7 1.3 -0.2 -1.1
Unable to work because of sickness or disability 0.8 1.0 1.2 -0.9 -1.1
Commuting to job workplace: Cycle 0.2 0.3 0.5 -0.3 -0.7
Myopia 0.2 0.2 0.4 0.2 0.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.2 -1.1 -0.7
Cholesterol lowering medication 0.7 1.1 1.9 -0.5 1.4
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.0 -1.4 0.0
Pain experienced in last month 0.6 0.9 1.2 -0.8 -1.1
Supplements: Calcium 0.0 0.1 0.1 0.3 -0.1
Basal cell carcinoma (self-reported) 1.6 1.9 2.6 1.1 1.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.2 -0.7 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 0.0 -0.5
Heart disease (siblings) 0.2 0.3 0.4 -0.7 0.4
Alcohol drinker status: Previous 1.1 1.2 2.4 -1.6 0.3
Pack years of smoking 1.1 1.6 3.2 -1.8 0.3
Impedance of whole body 0.4 2.1 4.2 -2.1 -0.2
Leg fat mass (left) 0.4 1.5 1.8 -1.1 1.3
Arm predicted mass (left) 0.6 3.2 6.4 0.2 2.5