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chr6:33,662,667-36,121,375

Best TWAS P=7.95e-22 · Best GWAS P=2.9e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Coronary	ANKS1A	0.23	0.09	lasso	17	0.09	5.8e-04	-1.744	5.5	3.7e-08	-0.24	0.06	0.08	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	C6orf106	0.20	0.00	lasso	5	0.00	2.7e-01	-6.071	-5.9	4.1e-09	0.15	0.07	0.06	FALSE
3	GTEx	Cells Transformed fibroblasts	NUDT3	0.11	0.03	lasso	3	0.02	9.2e-03	-6.099	5.9	4.7e-09	-0.19	0.08	0.69	FALSE
4	GTEx	Muscle Skeletal	C6orf106	0.08	0.06	lasso	4	0.06	7.1e-07	-5.396	6.2	4.7e-10	-0.14	0.98	0.00	FALSE
5	GTEx	Nerve Tibial	DEF6	0.15	0.00	lasso	8	0.00	1.6e-01	-9.427	5.8	5.8e-09	-0.81	0.02	0.87	FALSE
6	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	-5.517	-5.1	2.7e-07	0.03	0.86	0.01	TRUE
7	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	-5.716	6.0	2.4e-09	-0.78	0.85	0.10	FALSE
8	GTEx	Whole Blood	DEF6	0.14	0.05	lasso	4	0.03	9.9e-04	-9.384	6.6	3.4e-11	-0.84	0.02	0.98	FALSE
9	METSIM	Adipose	ZNF76	0.11	0.07	blup	405	0.06	6.3e-10	-9.075	9.6	8.0e-22	-0.81	0.08	0.92	TRUE
10	NTR	Blood	DEF6	0.03	0.02	bslmm	420	0.02	7.2e-07	-9.441	8.6	8.8e-18	-0.84	0.02	0.98	FALSE
11	NTR	Blood	ZNF76	0.01	0.00	blup	424	0.00	3.8e-02	-9.210	8.0	9.6e-16	-0.81	0.05	0.79	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	-5.677	7.0	2.4e-12	-0.88	0.03	0.96	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	ZNF76	0.04	0.00	blup	424	0.02	2.1e-03	-9.459	8.9	5.6e-19	-0.82	0.02	0.96	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	-5.002	-5.8	8.6e-09	0.07	0.10	0.51	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	RPS10	0.11	0.01	blup	356	0.04	5.0e-06	-6.713	-5.6	1.7e-08	0.33	0.00	0.99	TRUE
16	ROSMAP	Brain Pre-frontal Cortex	RPL10A	0.30	0.18	bslmm	409	0.19	2.6e-24	-3.840	-5.2	1.7e-07	0.31	1.00	0.00	FALSE
17	YFS	Blood	ANKS1A	0.04	0.00	bslmm	451	0.02	6.8e-07	0.025	-6.7	1.9e-11	0.38	0.74	0.11	FALSE
18	YFS	Blood	RPS10	0.05	0.05	bslmm	353	0.05	2.2e-16	-6.713	-6.5	9.6e-11	0.28	0.01	0.99	FALSE
19	YFS	Blood	ZNF76	0.05	0.08	lasso	4	0.07	6.7e-23	-9.433	9.4	3.4e-21	-1.00	0.02	0.98	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL10A	0.03	0.00	blup	55	0.01	1.4e-03	-3.791	-6.1	9.1e-10	0.51	0.03	0.42	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS10	0.01	0.01	enet	1	0.01	1.2e-02	-6.713	-6.7	1.9e-11	0.26	0.00	0.99	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf106	0.04	0.01	blup	68	0.01	2.4e-02	-5.479	-5.8	6.7e-09	0.12	0.01	0.68	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	-5.543	-5.2	2.3e-07	0.11	0.01	0.99	TRUE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	DEF6	0.04	0.01	blup	50	0.03	6.2e-04	-9.410	8.2	3.1e-16	-0.88	0.01	0.95	FALSE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF76	0.08	0.05	lasso	10	0.07	4.9e-04	-8.023	-8.6	9.5e-18	0.85	0.04	0.51	TRUE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FKBP5	0.19	0.01	blup	84	0.05	4.0e-03	-0.641	5.1	3.0e-07	0.02	0.01	0.09	TRUE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL10A	0.09	0.03	enet	19	0.07	1.1e-07	-3.791	-5.2	2.2e-07	0.38	0.83	0.12	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF76	0.03	0.02	lasso	3	0.02	3.5e-03	-5.204	7.7	1.0e-14	-0.86	0.04	0.86	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PPARD	0.12	0.10	lasso	5	0.05	5.3e-03	-5.765	6.5	6.7e-11	-0.52	0.34	0.08	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	SCUBE3	0.03	0.01	blup	62	0.03	8.9e-04	-8.017	9.4	5.6e-21	-0.92	0.03	0.79	FALSE