TWAS hub - TFEB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3780	0.1200	0.0091	0.148	NA	0.138	NA	0.185	4.0e-05	NA	7.1e-05	NA	3.8e-06
2	METSIM	Adipose	0.0792	0.0286	0.0025	0.035	0.007	0.018	NA	0.028	5.1e-06	0.0270	8.5e-04	NA	4.6e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0415	0.0187	0.0090	-0.002	0.019	-0.002	NA	-0.002	6.2e-01	0.0027	6.6e-01	NA	7.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Blood Red Count	19.0	183.5	519.8	-1.9	22.8	5.2
Illnesses of father: High blood pressure	6.0	7.4	14.4	0.1	3.8	2.8
Ever had bowel cancer screening	4.9	5.7	10.5	0.6	3.2	2.5
HDL Cholesterol	4.8	8.0	10.1	2.0	3.2	3.1
Medication: Omeprazole (e.g. Zanprol)	3.4	4.2	5.5	-1.3	2.3	2.3
Neck or shoulder pain in last month	3.3	4.7	10.9	-0.3	3.3	1.8
LDL Cholesterol	3.2	5.0	8.0	-0.1	-2.6	-2.8
Handedness (chirality/laterality): Left-handed	3.0	3.6	7.6	1.3	2.8	1.2
Supplements: Calcium	3.0	3.3	6.2	-0.8	1.7	2.5
Prospective memory result	2.9	3.6	6.2	-0.5	-2.5	-2.1
Chest pain or discomfort	2.9	4.2	7.3	0.0	2.7	2.3
Fasting Glucose	2.8	3.4	5.8	-2.4	2.1	0.0
Average weekly red wine intake	2.8	4.1	5.1	1.9	2.0	2.3
Illnesses of father: None of the above (group 1)	2.8	3.5	5.4	-0.5	-2.2	-2.3
Blood White Count	2.7	20.0	30.4	1.9	-5.5	-5.1
Pulse rate, automated reading	2.7	8.7	13.5	3.2	-1.5	-3.7
Heel bone mineral density (BMD) T-score, automated (left)	2.6	6.0	16.3	4.0	0.4	1.2
Alcohol drinker status: Never	2.6	3.1	5.1	-2.3	1.9	0.6
Pulse rate	2.5	4.2	4.5	2.1	-2.0	-2.0
Qualifications: nursing, teaching	2.5	3.9	10.3	-0.8	3.2	0.9
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	8.5	0.5	2.9	1.7
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	5.2	0.5	1.6	2.3
Length of working week for main job	2.3	2.5	4.6	-0.2	2.1	1.7
Wears glasses or contact lenses	2.3	2.6	5.7	1.3	2.4	0.7
Ever taken oral contraceptive pill	2.3	2.6	5.5	1.5	-2.3	-0.3
Pain type(s) experienced in last month: Hip pain	2.3	2.9	5.7	-0.4	2.4	1.7
Pain experienced in last month	2.3	3.8	9.2	0.4	-3.0	-1.4
Medication for hormone replacement therapy	2.1	2.3	5.5	2.3	-0.7	-1.0
Glaucoma (self-reported)	2.1	2.5	7.1	2.7	-0.2	0.6
Osteoporosis (self-reported)	2.1	2.5	5.2	-0.6	1.4	2.3
Ever smoked	2.1	3.7	8.9	1.4	-3.0	-0.4
Type 2 Diabetes (T2D) (2018)	2.0	3.7	8.7	0.9	-3.0	-1.2
Had menopause	2.0	2.6	4.2	1.4	1.2	2.0
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	6.1	1.4	1.2	2.5
High blood pressure (siblings)	2.0	2.8	6.3	0.9	2.5	1.2
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.2	1.3	-2.1	-1.3
Financial difficulties in last 2 years	1.9	2.6	4.0	-1.2	1.5	2.0
Back pain experienced in last month	1.9	2.8	5.2	0.1	2.3	1.8
Lung FVC	1.8	9.0	17.3	-0.1	3.1	4.2
Worrier / anxious feelings	1.8	3.4	8.3	-1.1	0.9	2.9
Illnesses of father: Heart disease	1.8	2.6	5.3	0.2	1.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	10.0	-0.1	-1.0	-3.2
Medication: Gliclazide	1.8	2.1	3.8	1.5	-1.9	0.4
Bipolar Disorder (2018)	1.7	2.8	4.2	-1.0	-2.0	-1.7
Bipolar Disorder or Schizophrenia	1.7	4.2	4.7	-2.0	-2.2	-1.9
Supplements: Zinc	1.7	1.8	3.6	0.9	1.0	1.9
Heart attack	1.7	2.1	3.2	1.2	-1.8	-1.3
Falls in the last year	1.7	2.2	4.6	0.4	1.4	2.1
Mouth/teeth dental problems: Dentures	1.7	2.9	4.4	2.1	-2.1	-0.2
Wheeze or whistling in the chest in last year	1.7	3.0	6.4	-2.5	1.3	1.1
Medication: Metformin	1.6	2.3	5.3	0.5	-2.3	-1.1
Medication: Atenolol	1.6	2.1	6.1	0.0	0.3	2.5
Past tobacco smoking	1.6	3.0	6.9	-1.2	2.6	0.7
Qualifications: None of the above	1.6	3.4	7.0	0.3	-2.6	-1.7
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.0	-0.6	1.7	1.7
Medication for pain relief, constipation, heartburn	1.6	2.7	5.0	-0.4	-1.7	-2.2
Migraine (self-reported)	1.6	2.0	3.7	-0.1	1.9	1.5
Medication: Omeprazole	1.6	1.9	3.7	-0.8	1.2	1.9
Irritable Bowel Disease (IBD)	1.5	3.5	7.9	-2.8	0.9	1.4
Angina	1.5	2.0	4.0	1.3	0.6	2.0
Alcohol usually taken with meals	1.5	2.5	7.2	-0.4	2.7	0.3
Angina (self-reported)	1.5	1.9	3.5	1.4	0.4	1.9
Reaction Time	1.4	2.7	5.0	-0.8	-1.5	-2.2
Body Mass Index (BMI) (2010)	1.4	1.9	5.7	-2.4	0.2	-0.1
Vitamin and mineral supplements	1.4	1.9	3.3	-1.0	-1.1	-1.8
Mouth/teeth dental problems	1.4	2.1	4.3	-2.1	1.5	0.0
Medication: Ramipril	1.4	1.8	4.6	0.8	-2.1	-0.2
Illnesses of siblings	1.4	2.0	5.9	-0.4	-2.4	-0.1
Hair/balding pattern: Pattern 3	1.4	2.1	3.5	0.9	-1.9	-1.4
Crohns Disease (2017)	1.3	2.9	8.7	-2.9	-0.1	0.4
Breast Cancer	1.3	3.1	6.5	1.0	1.3	2.5
Crohns Disease (2012)	1.3	2.1	5.6	-2.4	-0.5	-0.7
Neuroticism (2016)	1.3	1.8	5.0	-2.2	-0.2	-0.7
Number of live births	1.3	1.8	2.9	1.7	-1.6	-0.2
Noisy workplace	1.3	1.6	2.8	1.7	0.5	1.3
Loud music exposure frequency	1.3	1.4	2.9	-0.6	-1.7	-1.0
Medication: Seretide 50 evohaler	1.3	1.5	2.8	-0.6	1.1	1.7
Mean time to correctly identify matches	1.3	2.6	4.5	-0.4	-1.7	-2.1
Comparative height size at age 10	1.3	7.1	16.3	-1.9	-1.2	-4.0
Average weekly beer plus cider intake	1.3	1.8	3.9	1.2	-2.0	-0.4
Fractured/broken bones in last 5 years	1.3	1.7	3.0	1.3	1.7	0.5
Myopia	1.3	1.8	3.5	0.8	-1.2	-1.9
Chronotype (morning person)	1.2	2.8	3.6	1.9	-1.1	1.9
Number of treatments/medications taken	1.2	2.2	5.8	-0.1	0.9	2.4
Medication: Co-codamol	1.2	1.3	3.2	-0.8	1.8	-0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.8	0.8	0.5	1.7
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.2	-0.3	2.7	0.8
Stomach or abdominal pain in last month	1.2	1.5	3.2	-1.0	1.8	0.5
High blood pressure (mother)	1.2	1.7	4.0	0.1	1.1	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	3.1	1.7	1.2	1.8
Age started oral contraceptive pill	1.2	1.5	2.4	1.3	0.7	1.6
Alzheimer’s Disease (in father)	1.1	1.2	1.9	-0.2	-1.4	-1.3
Schizophrenia (2014)	1.1	2.4	3.4	-1.4	-1.9	-1.3
Smoking Status	1.1	2.5	5.1	0.6	-2.3	-1.4
Sitting height	1.1	7.7	15.1	0.0	-2.8	-3.9
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	6.9	2.6	0.2	0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.9	-0.3	-0.4	2.0
Exposure to tobacco smoke outside home	1.1	1.4	2.6	0.6	1.6	1.1
Medication: Ibuprofen	1.1	1.3	2.0	-1.3	1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.2	1.0	-1.5	-0.7
Mineral and other dietary supplements	1.1	1.5	2.7	0.2	-1.4	-1.6
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.5	1.0	0.8	1.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	0.7	-1.0	-1.6
Ulcerative Colitis (UC)	1.0	1.9	2.8	-1.1	1.3	1.7
Triglycerides	1.0	1.6	2.4	-1.2	-1.1	-1.5
Height	1.0	19.9	40.1	-1.1	-4.3	-6.3
Waist Hip Ratio (WHR)	1.0	4.5	7.4	-1.3	-2.1	-2.7
Allergy or Eczema	1.0	2.6	5.4	-1.3	2.3	0.8
Diabetes (mother)	1.0	1.3	2.2	0.3	-1.3	-1.5
Allergy	1.0	2.3	5.8	0.9	-2.4	-0.4
Comparative body size at age 10	1.0	2.6	4.5	0.1	-1.9	-2.1
Medication: Aspirin	1.0	1.4	2.6	1.6	-0.8	0.9
Knee pain experienced in last month	1.0	1.6	1.8	1.2	1.3	1.3
Smoking status: Previous	1.0	1.5	4.0	0.6	-2.0	-0.6
Financial situation satisfaction	1.0	1.3	2.9	-0.6	0.7	1.7
Medication: Paracetamol	1.0	1.6	1.7	-1.3	1.2	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.2	1.5	-1.2	-0.1
Diabetes (self-reported)	0.9	1.5	3.3	-0.2	-1.8	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.1	-0.8	1.5	0.9
Illnesses of mother	0.9	1.2	2.5	-1.6	-0.2	1.0
Peak expiratory flow (PEF)	0.9	2.1	3.3	1.8	0.9	1.5
Health satisfaction	0.9	1.1	2.7	-0.6	0.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.2	0.9	-1.5	-0.7
Supplements: Vitamin C	0.9	1.1	1.6	0.2	1.3	1.3
Guilty feelings	0.9	1.3	1.5	1.2	-1.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	0.9	1.6	0.2
Schizophrenia (2018)	0.8	1.8	3.1	-1.8	-1.1	-1.0
Coronary Artery Disease (CAD)	0.8	0.9	1.4	-1.2	0.4	-1.1
Rheumatoid Arthritis	0.8	1.1	3.3	1.8	0.0	0.2
Ulcerative Colitis	0.8	1.1	3.0	-1.7	-0.2	-0.6
Respiratory disease	0.8	1.8	2.5	-1.4	1.6	0.9
Hand grip strength (left)	0.8	2.2	4.9	0.3	2.2	1.2
Sensitivity / hurt feelings	0.8	1.4	2.7	-1.0	0.7	1.6
Systolic blood pressure, automated reading	0.8	2.3	5.9	-2.4	0.7	0.7
Maternal smoking around birth	0.8	1.1	2.1	1.4	-1.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.7	-1.3	0.1	1.2
Serious illness, injury or assault to yourself	0.8	1.0	2.0	-0.7	1.4	0.6
Supplements: Glucosamine	0.8	1.0	1.3	0.8	1.2	1.0
Chronic bronchitis/emphysema (father)	0.8	1.0	2.6	1.6	0.5	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.0	0.9	1.4
Pulse wave reflection index	0.8	1.0	2.0	-1.4	-1.0	-0.0
Headache pain in last month	0.8	1.4	3.4	-1.8	0.8	0.4
Number of full brothers	0.8	1.0	2.2	1.5	0.7	0.7
Alcohol intake frequency.	0.8	1.8	4.6	-0.6	2.1	0.6
Diabetes diagnosed by doctor	0.8	1.3	2.9	-0.5	-1.7	-0.9
Commuting to job workplace: Walk	0.8	0.8	1.3	-0.2	1.1	1.1
Irritability	0.8	1.4	3.0	0.8	0.8	1.7
Ovarian Cancer	0.7	1.0	1.4	-1.2	1.1	0.5
Age at First Birth	0.7	1.0	1.3	-0.8	-1.2	-1.0
Primary Biliary Cirrhosis	0.7	0.9	1.9	-0.1	-1.4	-0.9
Relative age of first facial hair	0.7	1.5	4.0	0.3	-0.6	2.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.5	0.3	1.2	1.0
Age when periods started (menarche)	0.7	1.8	4.7	0.7	-2.2	0.1
High blood pressure	0.7	1.8	3.3	-1.5	0.3	1.8
Neuroticism score	0.7	1.4	3.5	0.1	0.8	1.9
Father’s age at death	0.7	0.9	2.5	0.4	1.6	0.0
Medication: Cholesterol lowering	0.7	1.1	3.0	0.3	-0.5	1.7
Impedance of arm (left)	0.7	3.2	9.5	0.3	-3.1	0.0
Standing height	0.7	7.0	13.3	-0.4	-2.8	-3.6
Medication: Paracetamol	0.7	1.2	2.2	-0.1	1.2	1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.4	-0.8	0.6	-1.5
Mother’s age at death	0.7	0.9	1.2	1.1	0.6	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	1.1	-0.7	0.8
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	0.8	-0.1	-1.3
Major Depression (MDD)	0.6	0.8	1.5	-1.2	0.9	0.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	-0.2	-0.9	-1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	0.4	1.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.0	-0.9	-0.5	1.0
Townsend deprivation index at recruitment	0.6	0.9	2.5	-0.2	-1.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.4	1.5	-0.4	0.7
Alcohol intake versus 10 years previously	0.6	0.8	2.0	-0.2	1.4	0.7
Asthma	0.6	1.1	2.0	-1.4	1.1	-0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-0.8	-1.1	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.8	2.2	-0.3	1.5	0.2
Leg fat percentage (right)	0.6	2.3	5.3	0.7	1.0	2.3
Number of children fathered	0.6	0.7	1.6	-0.3	-0.6	-1.2
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.3	-1.1	-0.9
Emphysema/chronic bronchitis	0.6	0.6	1.1	-1.1	0.9	0.0
Osteoarthritis (self-reported)	0.6	0.8	1.3	-1.1	0.8	-0.5
Average weekly champagne plus white wine intake	0.6	0.9	2.2	-0.7	1.5	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.5	1.2	-0.0	0.8
Mean Putamen Volume	0.5	0.6	0.9	0.9	0.4	0.8
Heel T-Score	0.5	3.8	8.7	3.0	-0.3	1.6
Average weekly spirits intake	0.5	0.6	0.9	1.0	0.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	-0.2	1.3	0.3
Pack years adult smoking proportion	0.5	0.7	1.4	-0.1	-1.2	0.9
Relative age voice broke	0.5	0.8	2.1	-0.1	0.4	1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	0.8	1.0	0.5
Impedance of arm (right)	0.5	2.4	7.0	-0.3	-2.7	-0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.5	-0.4	1.6	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	1.0	-0.8	0.3
Age at first live birth	0.5	0.9	1.8	-0.7	1.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	0.9	0.6	-0.9	-0.8
Number of full sisters	0.5	0.6	0.9	0.9	0.7	0.5
Long-standing illness, disability or infirmity	0.5	0.8	1.1	0.8	0.7	1.1
Breast cancer (self-reported)	0.5	0.6	1.7	-0.2	-1.3	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	1.2	0.1	-1.6
Cholesterol lowering medication	0.5	0.8	1.8	-0.1	-0.8	-1.3
Pack years of smoking	0.5	0.7	1.1	-0.1	-1.0	1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	0.6	-0.5	-1.0
Lupus	0.4	0.6	1.4	0.3	-1.2	-0.6
Cardiovascular Disease	0.4	1.4	3.4	-0.7	-0.7	1.8
Neuroticism	0.4	1.0	2.1	0.4	0.8	1.4
Trunk fat percentage	0.4	1.5	2.8	1.1	-1.7	0.6
Taking other prescription medications	0.4	0.7	1.5	-0.1	0.7	1.2
Number of incorrect matches in round	0.4	0.6	1.0	-1.0	0.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	0.2	1.1	-0.2
Medication: Simvastatin	0.4	0.6	1.2	0.1	-0.8	1.1
Medication: Lansoprazole	0.4	0.4	0.7	-0.3	0.7	0.8
Lung cancer (father)	0.4	0.5	0.6	-0.8	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.4	0.8	1.1	1.2
Hair/balding pattern: Pattern 4	0.4	1.1	3.0	-0.4	1.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-0.4	-1.0	-0.6
Pulse wave peak to peak time	0.4	0.5	0.7	0.8	0.9	0.3
Medication: Blood pressure	0.4	0.6	0.9	0.9	-0.9	0.5
Overall health rating	0.4	0.8	1.2	-1.0	-1.1	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	-0.7	0.9	0.3
Hypertension (Self-reported)	0.4	1.2	2.6	-1.0	0.1	1.6
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.2	1.2	-0.2
Leg fat-free mass (right)	0.4	1.9	4.1	0.4	-1.2	-2.0
Mood swings	0.4	0.8	1.4	0.1	1.2	0.9
Friendships satisfaction	0.4	0.6	1.0	0.7	-1.0	0.3
Asthma (self-reported)	0.4	0.8	1.2	-1.1	1.1	-0.0
Leg predicted mass (right)	0.4	2.0	4.4	0.4	-1.2	-2.1
Medication: Bendroflumethiazide	0.4	0.6	1.4	0.3	-0.5	-1.2
Medication: Atorvastatin	0.4	0.4	1.1	1.1	0.5	-0.1
Leg fat percentage (left)	0.4	1.5	4.0	0.4	0.6	2.0
Risk taking	0.4	0.6	1.6	0.3	-0.4	-1.2
Commuting to job workplace: Cycle	0.4	0.5	0.7	-0.0	-0.8	-0.8
Worry (Nagel 2018)	0.3	0.6	1.3	0.5	0.5	1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.9	-0.3	-0.7	-1.4
HbA1C	0.3	0.3	0.4	-0.6	0.6	-0.3
Blood Eosinophil Count	0.3	2.7	7.6	2.8	-0.6	-0.2
Systolic Blood Pressure	0.3	1.4	4.0	-2.0	-0.2	0.0
Hypothyroidism (self reported)	0.3	0.8	1.5	0.8	-0.3	1.2
Lung FEV1/FVC ratio	0.3	1.6	3.5	0.5	-1.9	-0.9
Hearing difficulty/problems: Yes	0.3	0.5	1.1	0.5	-1.1	-0.3
Diabetes (father)	0.3	0.4	0.9	-0.2	0.9	0.5
Impedance of leg (right)	0.3	1.5	3.9	-0.7	0.3	2.0
Hand grip strength (right)	0.3	0.9	2.3	0.3	1.5	0.5
Fed-up feelings	0.3	0.5	0.8	-0.8	0.3	0.9
Medication: Levothyroxine sodium	0.3	0.4	0.5	0.7	-0.6	0.7
Impedance of leg (left)	0.3	1.4	3.0	-1.0	-0.0	1.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.6	-0.6	0.0	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	0.4	0.2
Time employed in main current job	0.3	0.4	0.9	0.9	0.2	-0.5
Birth weight of first child	0.3	0.5	1.3	0.2	-1.2	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.7	-0.8	-0.2	-0.7
Heart disease (mother)	0.3	0.3	0.6	-0.8	0.3	-0.5
Had major operations	0.3	0.4	0.6	0.8	0.3	-0.6
Family relationship satisfaction	0.3	0.3	0.7	0.8	-0.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.3	0.6	0.8
Loneliness, isolation	0.3	0.4	1.2	-0.1	0.1	1.1
Eye problems/disorders: Cataract	0.3	0.3	0.6	0.8	0.6	0.2
Medication for cholesterol	0.3	0.5	0.6	-0.7	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.1	0.3	-0.9
Medication: Aspirin	0.3	0.4	0.7	0.8	-0.7	0.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	0.4	0.3	1.1
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.7	0.1	-0.7
Diastolic blood pressure, automated reading	0.3	1.0	1.9	-0.9	1.4	0.6
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	-0.7	-0.2
Impedance of whole body	0.3	1.7	4.5	-0.4	-2.1	0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	0.1	1.1	0.4
Tanning	0.2	1.9	4.9	-0.6	-2.2	-0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	0.1	-0.6	-0.5
Leg fat-free mass (left)	0.2	1.3	2.6	0.6	-0.9	-1.6
Current tobacco smoking	0.2	0.4	0.9	-0.9	-0.2	-0.5
Leg predicted mass (left)	0.2	1.2	2.6	0.5	-0.8	-1.6
Trunk fat mass	0.2	1.0	2.0	0.9	-1.4	-0.1
Waist circumference	0.2	0.8	1.3	-0.0	-1.1	-1.1
Had other major operations	0.2	0.2	0.7	0.1	-0.2	-0.8
Trunk fat-free mass	0.2	1.4	3.9	0.0	0.4	-2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.8	1.3	0.3	0.7
Depression (self-reported)	0.2	0.2	0.4	0.6	-0.3	0.3
Trunk predicted mass	0.2	1.3	3.8	-0.1	0.5	-1.9
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.3	-0.7	0.4
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.1	0.8	0.4
Gout (self-reported)	0.2	0.3	0.8	-0.1	0.9	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.6	0.6	-0.6	0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.3	-0.3	1.1	1.0
Body fat percentage	0.2	0.9	1.3	0.9	-0.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.3	-0.3	0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.1	-0.7	-0.6
Suffer from ‘nerves’	0.2	0.3	0.5	0.2	-0.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.8	-0.4	0.1
Whole body fat-free mass	0.2	1.2	3.5	0.3	-0.1	-1.9
Arm fat percentage (left)	0.2	0.9	1.4	1.2	-0.8	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	0.8	0.4	-0.6
Smoking status: Current	0.2	0.3	0.6	-0.3	-0.5	-0.8
Whole body water mass	0.2	1.2	3.6	0.2	0.0	-1.9
High cholesterol (Self-reported)	0.2	0.4	0.8	0.3	-0.9	0.4
Basal metabolic rate	0.2	0.9	2.7	0.3	-0.2	-1.6
Number of operations (self-reported)	0.2	0.2	0.7	0.1	-0.8	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.3	0.8	0.3
Heart disease (siblings)	0.2	0.3	0.7	0.8	0.1	0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	0.5	0.0	0.7
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	0.4	0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.8	0.2	0.3
Blood Platelet Count	0.1	0.8	1.2	-0.4	-1.0	-1.1
Hair Pigment	0.1	4.1	7.5	-1.1	1.9	2.7
Severe depression (siblings)	0.1	0.1	0.2	-0.4	-0.2	-0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.5	-0.7	-0.1	0.1
Multivitamins +/- minerals	0.1	0.2	0.5	0.2	0.2	0.7
Body mass index (BMI)	0.1	0.6	0.7	0.8	0.7	0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.7	0.2	0.3
Forced vital capacity (FVC)	0.1	0.3	0.7	0.8	0.1	0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.2	0.4	-0.1
Fluid intelligence score	0.1	0.1	0.3	0.6	-0.0	-0.1
Weight	0.1	0.4	0.8	0.4	-0.6	-0.9
Arm fat percentage (right)	0.1	0.4	0.5	0.7	-0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.3	0.3	-0.3
Tense / ‘highly strung’	0.1	0.1	0.2	-0.4	0.2	0.2
Medication: Amlodipine	0.1	0.2	0.4	0.2	0.6	0.3
Birth weight	0.1	0.1	0.3	0.6	0.2	-0.2
Arm fat-free mass (right)	0.1	0.5	1.3	-0.1	0.5	-1.1
Worry too long after embarrassment	0.1	0.1	0.1	0.3	-0.2	0.4
Medication: Allopurinol	0.1	0.1	0.2	-0.1	0.4	-0.1
Whole body fat mass	0.1	0.3	0.6	0.8	-0.5	0.4
Leg fat mass (right)	0.1	0.4	0.7	0.8	0.2	0.6
Arm predicted mass (right)	0.1	0.6	1.7	-0.2	0.4	-1.3
Age at last live birth	0.1	0.2	0.3	0.5	-0.5	-0.4
Leg pain on walking	0.1	0.1	0.3	0.2	-0.6	-0.1
Arm fat mass (left)	0.1	0.3	0.6	0.8	-0.3	0.1
Miserableness	0.1	0.2	0.2	0.5	0.5	0.2
Hearing aid user	0.1	0.1	0.2	0.2	0.0	-0.4
Medication: Blood pressure	0.1	0.1	0.3	-0.5	0.2	0.1
Arm fat-free mass (left)	0.1	0.6	1.0	-0.3	0.8	-1.0
Ever depressed for a whole week	0.1	0.2	0.3	0.4	0.3	0.5
Leg fat mass (left)	0.1	0.3	0.6	0.8	-0.1	0.4
Arm predicted mass (left)	0.1	0.5	0.9	-0.3	0.7	-0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.2	0.5	0.7	-0.1	0.2
Average weekly fortified wine intake	0.0	0.0	0.1	0.2	-0.0	-0.1
Nervous feelings	0.0	0.1	0.2	0.1	0.2	0.5
Hip circumference	0.0	0.1	0.2	0.1	-0.3	-0.4
Happiness	0.0	0.0	0.1	-0.2	-0.3	0.0
Arm fat mass (right)	0.0	0.1	0.2	0.5	-0.4	0.0
Breastfed as a baby	0.0	0.1	0.1	-0.3	0.3	0.1
Qualifications: College or University degree	0.0	0.1	0.1	-0.1	0.3	-0.3
Medication: Lisinopril	0.0	0.0	0.1	-0.3	0.0	-0.2

Hub : Genes

TFEB

Models

Trait associations