TWAS hub - UNC5CL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.0920	0.0410	0.0085	0.036	NA	0.012	NA	0.017	2.9e-03	NA	6.1e-02	NA	2.9e-02
2	GTEx	Stomach	0.2070	0.0780	0.0057	0.036	NA	0.085	NA	0.086	7.6e-03	NA	7.1e-05	NA	6.5e-05
3	METSIM	Adipose	0.0512	0.0211	0.0018	0.029	0.011	0.021	0.018	0.027	2.9e-05	0.00780	3.3e-04	0.00081	5.2e-05
4	TCGA	Colon Adenocarcinoma	0.0630	0.0410	0.0035	0.067	0.014	0.018	NA	0.037	1.1e-04	0.05200	2.9e-02	NA	3.3e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0368	0.0274	0.0047	0.041	0.025	0.027	NA	0.039	1.9e-05	0.00072	4.7e-04	NA	3.1e-05
6	TCGA	Thyroid Carcinoma	0.0360	0.0220	0.0017	0.017	0.018	0.008	NA	0.011	8.2e-03	0.00590	5.0e-02	NA	2.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Alzheimer’s Disease (including proxy)	5.0	7.2	10.4	3.2	1.2	-1.9	3.1	3.0	3.0
Medication: Seretide 50 evohaler	4.1	4.8	7.8	-2.8	-1.6	2.5	-1.6	-2.3	-2.1
BMI	3.2	18.5	28.3	-2.9	-0.0	5.1	-5.2	-4.6	-5.3
Miserableness	3.1	5.4	8.4	-1.5	-2.3	1.7	-2.5	-2.9	-2.6
Body Mass Index (BMI) (2010)	3.0	4.1	6.9	-0.6	-1.4	2.5	-2.1	-2.6	-2.2
Commuting to job workplace: Public transport	3.0	3.5	6.2	2.5	1.2	-1.3	1.7	2.0	2.1
Bipolar Disorder (2011)	2.9	2.8	5.2	-0.8	1.7	1.5	-1.4	-1.8	-2.3
Hip circumference	2.9	12.4	21.4	-2.9	-0.5	3.3	-4.1	-4.2	-4.6
Myopia	2.9	4.2	8.6	1.5	1.1	-2.9	1.8	2.2	2.4
Alzheimer’s Disease (in mother)	2.7	3.2	5.8	2.4	1.0	-1.0	2.2	1.9	1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	4.5	2.0	2.0	-2.1	1.9	1.2	1.2
Intelligence (Savage-Jansen 2018)	2.6	8.0	15.6	-0.7	0.6	2.9	-4.0	-3.3	-3.6
Type 2 Diabetes (T2D) (2012)	2.6	3.0	6.1	-0.8	-0.5	1.6	-2.3	-1.8	-2.5
Number of children fathered	2.4	2.7	4.5	-1.5	-1.4	2.1	-1.8	-1.2	-1.6
Body mass index (BMI)	2.3	9.7	15.8	-1.9	-0.5	3.4	-3.8	-3.6	-4.0
Waist circumference	2.3	8.4	15.2	-1.6	-0.0	2.8	-3.9	-3.3	-3.7
Leg fat percentage (right)	2.3	8.2	13.5	-1.5	-0.4	3.5	-3.5	-2.9	-3.7
Vitamin and mineral supplements	2.2	2.9	7.8	2.8	0.0	-0.8	0.2	2.2	2.1
Relative age of first facial hair	2.1	4.3	7.8	1.8	0.1	-2.1	2.8	2.1	2.4
Depression (self-reported)	2.1	2.5	5.0	-1.8	0.7	1.2	-1.7	-1.4	-2.2
Medication: Paracetamol	2.1	3.5	5.3	-1.7	-1.7	1.1	-2.0	-2.2	-2.3
Mood swings	2.1	3.7	6.7	-0.7	-1.2	1.6	-2.2	-2.6	-2.5
Arm fat percentage (right)	2.0	7.9	13.8	-1.7	-0.5	3.4	-3.7	-2.8	-3.4
Arm fat mass (right)	2.0	8.0	13.5	-1.7	-0.6	3.2	-3.7	-2.9	-3.5
Leg fat mass (right)	2.0	7.6	12.2	-1.8	-0.7	3.3	-3.4	-2.7	-3.5
Supplements: Vitamin C	2.0	2.3	4.5	-2.1	0.4	2.0	-1.4	-1.2	-1.4
Average weekly red wine intake	2.0	2.9	7.7	-0.1	0.4	1.5	-0.9	-2.8	-2.5
Average weekly fortified wine intake	1.9	2.2	11.7	-3.4	1.0	0.4	0.6	0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	7.4	0.2	-0.8	-2.4	2.5	2.1	2.7
Arm fat mass (left)	1.9	7.9	13.3	-1.8	-0.9	3.1	-3.6	-2.8	-3.5
Medication: Paracetamol	1.9	3.0	4.8	-1.4	-2.2	0.8	-1.8	-1.9	-2.0
Leg fat percentage (left)	1.9	6.8	11.3	-1.3	0.2	3.2	-3.4	-2.6	-3.4
Fasting Glucose	1.8	2.2	5.2	-1.7	0.7	2.3	-1.8	-0.6	-1.0
LDL Cholesterol	1.8	2.8	5.7	1.2	0.4	-1.8	2.1	1.4	2.4
Serious illness, injury or assault to yourself	1.8	2.2	6.5	-2.6	-0.7	1.5	-1.3	-0.9	-1.2
Heart disease (mother)	1.8	2.2	9.2	-0.3	0.6	-3.0	0.7	1.2	1.3
Arm fat percentage (left)	1.8	7.3	13.3	-1.3	-0.4	3.2	-3.6	-2.7	-3.4
Long-standing illness, disability or infirmity	1.8	2.7	5.0	-1.6	-1.2	2.2	-2.2	-1.2	-1.0
Alcohol drinker status: Never	1.8	2.2	4.2	1.1	0.8	-2.0	2.0	1.3	1.4
Leg fat mass (left)	1.8	7.1	11.6	-1.6	-0.5	3.1	-3.4	-2.6	-3.4
Depressed Affect (Nagel 2018)	1.7	3.7	6.2	-1.6	0.4	1.3	-2.4	-2.5	-2.4
Blood White Count	1.7	12.4	42.1	-1.0	-0.8	6.5	-3.7	-2.4	-3.4
Relative age voice broke	1.7	2.6	4.8	1.8	1.0	-1.7	2.2	1.2	1.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.1	-0.3	1.3	-2.3	1.6	1.3	1.4
Body fat percentage	1.7	6.7	12.4	-1.1	-0.2	3.0	-3.5	-2.6	-3.3
Whole body fat mass	1.7	7.2	12.0	-1.5	-0.6	3.1	-3.5	-2.7	-3.4
Cholesterol lowering medication	1.7	2.5	3.9	1.5	-0.5	-1.5	1.5	2.0	1.9
Angina	1.6	2.1	7.9	0.3	-2.8	-1.6	-0.8	1.0	0.7
Family relationship satisfaction	1.6	1.9	6.3	1.3	1.4	-2.5	1.1	-0.0	0.8
Asthma (self-reported)	1.6	3.1	7.0	0.0	-0.5	1.8	-1.8	-2.3	-2.6
Medication: Gliclazide	1.6	1.9	8.6	-2.9	-0.0	1.1	-0.7	-0.7	-0.5
Ovarian Cancer	1.5	2.0	6.4	0.8	-0.2	-2.5	1.3	0.9	1.5
Respiratory disease	1.5	3.3	6.2	-1.7	1.4	1.1	-1.3	-2.4	-2.5
Diabetes (father)	1.5	1.8	4.8	-1.2	1.3	2.2	-1.0	-1.1	-0.8
Trunk fat mass	1.5	6.6	11.6	-1.2	-0.7	2.9	-3.4	-2.5	-3.3
Weight	1.5	7.2	11.6	-1.7	-1.0	2.9	-3.4	-2.8	-3.4
Unable to work because of sickness or disability	1.5	1.9	4.9	-1.6	0.3	2.2	-1.6	-0.6	-1.0
Schizophrenia vs Biploar Disorder	1.4	1.8	3.3	-0.6	-1.1	1.8	-1.3	-1.4	-1.4
Trunk fat percentage	1.4	5.6	11.0	-0.8	-0.2	2.7	-3.3	-2.3	-3.1
Angina (self-reported)	1.4	1.8	7.5	0.2	-2.7	-1.3	-0.9	1.0	0.6
Knee pain experienced in last month	1.4	2.1	6.4	-2.5	-0.7	2.1	-0.3	-0.6	-1.0
Average weekly champagne plus white wine intake	1.4	1.9	2.7	1.3	-1.3	-1.0	1.4	1.6	1.6
Asthma	1.3	2.6	6.0	0.2	-0.3	1.5	-1.6	-2.1	-2.5
Exposure to tobacco smoke at home	1.3	1.5	2.6	-0.1	-1.4	-0.3	1.3	1.6	1.6
Emphysema/chronic bronchitis	1.3	1.4	8.0	-2.8	-0.2	-0.2	0.3	-0.6	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	4.4	1.1	-2.1	-0.4	1.0	1.1	1.0
Osteoarthritis (self-reported)	1.3	1.7	4.4	1.5	0.8	-1.2	2.1	0.6	1.0
Irritability	1.3	2.2	5.7	-0.3	-0.6	0.4	-2.4	-2.0	-1.7
Age started oral contraceptive pill	1.3	1.6	3.5	-0.8	-1.9	1.3	-1.3	-0.8	-1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.1	1.8	0.9	0.5	-1.0	-1.2	-1.3
Noisy workplace	1.2	1.5	2.3	-1.5	-0.8	1.2	-1.5	-1.2	-1.1
Pulse wave Arterial Stiffness index	1.2	1.4	2.9	0.6	-1.6	0.6	-1.7	-1.3	-0.9
Pulse wave peak to peak time	1.2	1.4	3.1	-0.5	1.2	-0.7	1.8	1.4	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.6	-1.6	-1.1	-0.4	0.4	1.4	1.5
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.7	0.2	1.4	0.7	-2.6	-1.9	-1.8
Breast Cancer	1.1	2.7	6.4	-0.5	-2.5	-2.5	1.1	0.9	1.2
Crohns Disease (2012)	1.1	1.8	4.3	1.7	0.2	0.5	-1.6	-1.0	-2.1
Multivitamins +/- minerals	1.1	1.5	6.9	-2.6	-0.1	-0.5	0.6	-0.9	-0.7
Number of incorrect matches in round	1.1	1.9	5.1	-0.2	-0.1	2.3	-1.3	-1.0	-1.8
Alcohol usually taken with meals	1.1	1.8	3.1	0.6	-0.7	1.8	-1.6	-1.5	-1.4
Mouth/teeth dental problems	1.1	1.7	3.1	-0.2	0.1	1.3	-1.8	-1.6	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	5.7	-1.3	-2.4	0.4	-0.1	0.0	-0.2
Number of full brothers	1.1	1.4	3.3	-0.4	-1.0	1.6	-1.8	-0.7	-0.9
Medication: Allopurinol	1.1	1.4	3.0	-1.4	-0.4	1.7	0.2	1.3	1.3
Overall health rating	1.1	2.3	4.7	-2.2	-1.5	1.0	-1.5	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.4	-0.7	-0.8	0.8	-1.2	-1.1	-1.5
Medication: Aspirin	1.1	1.5	3.8	-0.1	-1.9	-1.3	-0.0	1.1	1.4
Fractured/broken bones in last 5 years	1.1	1.5	2.9	1.2	0.4	-1.7	1.4	1.2	1.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.1	-1.4	-1.2	-1.4	0.8	0.9	1.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.7	-1.3	-1.0	0.7	-2.2	-1.4	-1.3
Severe depression (siblings)	1.0	1.2	3.7	-1.9	-0.9	0.3	-0.8	-1.3	-0.3
Fed-up feelings	1.0	1.8	4.0	-0.5	-0.6	0.6	-2.0	-2.0	-1.5
Medication: Ramipril	1.0	1.2	3.1	-0.0	-1.8	-1.6	0.3	0.3	1.3
Fluid intelligence score	1.0	2.1	7.8	1.8	2.8	-1.0	-0.5	-0.2	-0.3
Length of working week for main job	1.0	1.1	4.0	2.0	-1.1	-1.0	-0.3	-0.6	0.2
Gout (self-reported)	1.0	1.3	4.2	-1.7	-0.0	2.0	-1.0	0.2	0.3
Worry too long after embarrassment	1.0	1.6	4.2	-0.6	-2.0	0.7	-1.2	-1.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.2	-2.0	-0.4	1.0	-0.5	-0.8	-0.9
Back pain experienced in last month	1.0	1.5	2.5	1.3	-1.1	0.7	-1.2	-1.3	-1.6
Wears glasses or contact lenses	1.0	1.2	3.1	0.5	1.1	-1.8	1.0	0.8	0.9
Heart disease (siblings)	1.0	1.2	3.5	-1.9	-1.7	0.5	-0.2	-0.6	-0.3
Neuroticism (Nagel 2018)	0.9	2.1	3.4	-1.9	-0.9	0.3	-1.7	-1.7	-1.6
Schizophrenia (2018)	0.9	1.9	4.0	-1.7	0.4	0.9	-1.2	-1.5	-2.0
Alzheimer’s Disease (in father)	0.9	1.0	1.5	0.7	0.8	-0.8	1.2	1.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.0	-1.1	-1.4	1.3	-1.2	-1.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.0	-1.5	-0.3	-0.3	-1.7	-0.4	-0.5
Hearing difficulty/problems with background noise	0.9	1.4	3.4	-0.6	-0.3	0.9	-1.0	-1.6	-1.9
Had other major operations	0.9	1.1	3.6	1.2	0.5	-0.5	0.4	1.9	1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.0	-1.5	-0.6	1.7	-0.9	0.3	-0.6
Medication: Simvastatin	0.9	1.3	2.6	0.3	-0.8	-1.3	0.6	1.6	1.5
Illnesses of siblings	0.9	1.3	6.2	0.1	2.5	-0.3	-0.7	-0.6	-0.7
Father’s age at death	0.9	1.2	4.0	2.0	1.1	-0.9	0.8	0.3	0.4
Wheeze or whistling in the chest in last year	0.9	1.6	4.3	-0.3	0.2	1.0	-1.0	-1.7	-2.1
Eye problems/disorders: Glaucoma	0.9	1.1	3.2	0.4	1.4	0.4	-0.9	-0.5	-1.8
Medication: Atorvastatin	0.9	1.1	3.4	0.2	-1.8	-0.8	0.1	1.2	1.0
HbA1C	0.8	0.9	1.6	-1.2	0.0	0.4	-1.3	-1.2	-0.8
Rheumatoid Arthritis	0.8	1.1	1.9	-0.8	0.9	-1.4	0.9	1.1	1.0
Triglycerides	0.8	1.3	3.8	-0.9	-0.3	-0.9	0.9	1.1	2.0
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	0.9	-0.4	-0.9	-1.1	-1.1	-1.0
Supplements: Zinc	0.8	0.8	2.4	-1.3	-0.6	-1.5	0.6	0.2	0.4
Stomach or abdominal pain in last month	0.8	1.1	3.7	-0.5	0.5	1.9	-0.5	-0.8	-1.1
Qualifications: None of the above	0.8	1.7	3.3	-1.0	1.0	-1.0	1.2	1.6	1.8
Allergy	0.8	1.7	3.9	1.2	-0.3	-2.0	1.6	0.9	1.3
Happiness	0.8	1.0	2.5	0.5	1.6	-1.4	0.9	0.0	0.7
Lung cancer (father)	0.8	1.0	2.8	0.2	1.2	1.7	-0.0	1.3	0.1
Peak expiratory flow (PEF)	0.8	1.8	6.1	1.3	0.2	-1.3	2.5	0.8	0.9
Medication: Amlodipine	0.8	1.1	2.3	0.5	1.2	-1.3	0.2	1.5	1.0
Health satisfaction	0.8	1.1	2.2	-1.5	-1.1	1.3	-0.2	-0.7	-1.0
Shortness of breath walking on level ground	0.8	1.0	2.9	-1.1	0.0	1.7	-0.4	-0.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.5	1.6	1.0	-0.9	-0.7	0.9	0.4
Medication: Blood pressure	0.8	1.4	2.8	-1.5	0.3	0.7	-1.7	-0.8	-1.4
Medication: Omeprazole	0.8	1.0	2.7	1.6	0.4	-0.3	0.7	1.3	0.9
Medication: Aspirin	0.8	1.1	2.9	-0.0	-1.7	-1.2	-0.2	1.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	6.1	-0.9	-2.5	0.1	-0.6	0.6	0.3
Pain experienced in last month	0.8	1.3	2.7	0.2	0.3	-1.6	1.3	1.2	1.5
Major Depression (MDD)	0.7	0.8	1.4	-0.9	-1.2	0.6	-0.2	-1.1	-1.1
Diabetes (mother)	0.7	0.8	3.1	1.8	-0.5	-1.3	0.2	0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.7	1.9	1.0	-1.1	-0.6	-1.7	-0.7
Neuroticism score	0.7	1.5	3.0	-0.7	-1.4	0.4	-1.7	-1.3	-1.3
Alcohol intake versus 10 years previously	0.7	1.1	2.1	-1.4	0.2	1.2	-1.3	-0.8	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.3	3.4	0.5	0.1	-0.1	1.8	1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	1.3	-0.3	-0.0	1.4	0.7	1.1
Headache pain in last month	0.7	1.2	3.1	-0.1	0.0	1.8	-1.6	-0.7	-1.1
Glaucoma (self-reported)	0.7	0.8	2.4	0.2	1.5	0.7	-0.2	-0.1	-1.4
Leg pain on walking	0.7	0.8	2.3	0.2	-0.8	0.1	1.5	1.1	0.9
Illnesses of father: Heart disease	0.7	0.9	2.5	0.1	-1.6	0.3	-1.5	-0.5	-0.7
Qualifications: nursing, teaching	0.7	1.1	2.8	-0.3	-1.7	-0.6	-0.3	-1.6	-1.0
Medication for cholesterol	0.7	1.1	2.7	0.4	-0.2	1.5	-1.6	-0.7	-0.9
Ever depressed for a whole week	0.7	0.9	2.1	0.5	0.3	0.8	-1.5	-1.1	-1.0
Age at First Birth	0.6	0.9	2.7	-0.8	-0.3	1.6	-1.0	-0.2	-0.9
Lupus	0.6	0.9	2.1	-1.4	-0.9	0.2	-0.6	-1.3	-0.5
Neuroticism (2016)	0.6	0.9	2.0	-1.2	-1.4	0.5	-0.4	-0.9	-0.9
Blood Eosinophil Count	0.6	4.8	13.8	0.3	0.2	3.7	-2.7	-1.4	-2.4
Neuroticism	0.6	1.3	4.5	-1.2	-2.1	0.2	-1.2	-0.4	-0.6
Chronotype (morning person)	0.6	1.4	5.1	2.3	-0.4	-0.3	1.0	1.3	0.6
Medication for hormone replacement therapy	0.6	0.7	1.9	-1.4	0.7	0.7	1.1	0.1	-0.1
Maternal smoking around birth	0.6	0.9	1.8	1.4	-0.2	-1.2	1.2	0.3	0.7
Medication: Atenolol	0.6	0.7	2.6	-0.5	-0.6	-0.8	-1.6	-0.4	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-1.2	0.1	0.1	-0.5	-1.4	-0.8
Impedance of leg (left)	0.6	2.8	4.6	1.6	0.1	-1.8	1.4	2.1	2.1
Heart attack	0.6	0.7	2.7	-0.1	-1.6	-0.7	-0.5	0.3	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.8	-1.4	0.6	0.6	-1.0	-1.1	-1.0
Hair/balding pattern: Pattern 3	0.6	1.0	2.0	1.1	-0.5	0.1	0.9	1.4	1.2
Pulse rate	0.6	1.0	3.6	-1.9	-0.6	1.2	-0.3	0.4	0.7
Illnesses of mother	0.6	0.8	2.4	-0.1	-0.3	1.5	-1.0	-0.7	-0.9
Tense / ‘highly strung’	0.6	1.1	2.5	-0.1	-1.2	-0.2	-1.6	-1.0	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.6	-1.6	1.1	-0.1	-0.6	-0.6	-0.8
Pulse wave reflection index	0.6	0.7	2.9	1.7	0.0	-1.0	-0.4	-0.4	-0.1
Loud music exposure frequency	0.6	0.6	1.6	1.3	0.7	0.6	-0.7	-0.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	3.1	-0.8	1.8	-0.4	-0.7	0.2	0.0
Medication for pain relief, constipation, heartburn	0.6	1.0	3.3	0.5	1.8	-0.7	0.9	0.8	0.7
Neck or shoulder pain in last month	0.6	0.9	1.4	-1.2	1.0	1.2	-0.7	-0.5	-1.0
Medication: Ibuprofen	0.6	0.7	1.8	1.3	-0.6	0.1	1.3	0.2	0.7
Had major operations	0.6	0.7	1.6	-0.8	-0.5	0.8	-0.3	-1.3	-1.1
Friendships satisfaction	0.6	0.7	2.1	1.3	1.5	-0.5	-0.0	-0.0	0.3
Eye problems/disorders: Cataract	0.6	0.7	1.7	1.3	0.3	-0.8	0.7	1.1	0.4
Ever taken oral contraceptive pill	0.6	0.7	1.7	-0.8	-1.2	1.3	-0.3	-0.1	-0.2
Average weekly beer plus cider intake	0.6	0.9	4.5	-1.0	2.1	-0.1	0.3	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.8	-0.1	-1.7	-0.8	-0.5	0.3	0.7
Alcohol drinker status: Previous	0.6	0.7	1.9	-0.8	-0.6	0.4	-0.8	-1.4	-0.8
Impedance of whole body	0.6	3.2	6.7	1.6	-0.0	-1.5	1.5	2.6	2.4
Crohns Disease (2017)	0.5	1.1	2.5	1.1	-0.3	-0.2	-1.6	-0.5	-1.5
Coronary Artery Disease (CAD)	0.5	0.6	3.3	1.8	-0.4	-0.4	0.2	0.1	0.2
HDL Cholesterol	0.5	0.8	2.5	0.1	-0.1	1.6	-0.8	-0.2	-1.2
Schizophrenia (2014)	0.5	1.1	3.3	-0.9	0.5	0.7	-0.8	-0.9	-1.8
Pack years adult smoking proportion	0.5	0.7	2.8	0.1	1.7	-0.4	0.6	0.8	0.7
Leg fat-free mass (left)	0.5	2.8	5.1	-1.0	-0.7	1.6	-1.9	-2.0	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	-0.9	0.9	0.4	-1.0	-0.8	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	-0.2	-1.1	-0.8	-0.0	-1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.8	-0.7	0.3	-0.1	-1.0	-1.1
Medication: Levothyroxine sodium	0.5	0.9	1.8	0.1	-0.7	-1.1	0.9	1.0	1.3
Leg predicted mass (left)	0.5	2.9	5.2	-1.0	-0.7	1.6	-2.0	-2.0	-2.3
Had menopause	0.5	0.6	1.6	-0.5	0.7	-0.1	0.7	1.3	0.9
Time employed in main current job	0.5	0.6	1.6	-0.6	1.3	1.2	-0.1	0.2	0.0
Medication: Cholesterol lowering	0.5	0.8	2.9	-1.1	-1.7	-0.2	-0.7	0.7	0.3
Migraine (self-reported)	0.5	0.6	1.7	-1.3	1.0	0.1	0.2	0.1	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	1.1	-0.1	1.0	-0.6	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.3	1.8	-0.6	-1.1	0.4	0.5	0.8
Ever had bowel cancer screening	0.5	0.6	2.1	-1.4	0.1	0.2	-0.3	-0.7	-0.8
Diabetes diagnosed by doctor	0.5	0.8	2.7	-1.6	-0.3	0.2	-1.3	-0.6	-0.4
Commuting to job workplace: Walk	0.5	0.5	2.1	1.5	-0.1	0.4	-0.2	-0.7	-0.7
Osteoporosis (self-reported)	0.5	0.7	1.2	0.8	0.2	-0.4	1.0	1.1	1.0
Guilty feelings	0.5	0.8	1.6	-0.6	-1.3	0.6	-0.6	-1.1	-0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	-1.2	0.8	0.1	-0.4	-1.3	-0.4
Basal metabolic rate	0.5	2.8	5.1	-1.1	-1.0	1.5	-1.9	-2.0	-2.3
Pack years of smoking	0.5	0.7	2.6	0.0	1.6	-0.4	0.5	0.9	0.7
Bipolar Disorder or Schizophrenia	0.4	1.1	3.5	-1.0	0.5	-0.1	-0.8	-1.1	-1.9
Mean Putamen Volume	0.4	0.5	1.3	-0.5	-0.9	1.2	-0.6	0.4	-0.2
Lung FEV1/FVC ratio	0.4	1.9	2.9	1.2	0.0	-1.4	1.7	1.6	1.6
Average weekly spirits intake	0.4	0.5	2.4	0.1	-0.0	1.6	-0.6	0.1	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.5	-0.4	-1.6	-0.3	0.3	-0.0	-0.2
Systolic blood pressure, automated reading	0.4	1.1	2.4	-0.9	-0.8	-0.2	1.4	0.9	1.6
Medication: Co-codamol	0.4	0.5	1.3	0.4	-1.1	-0.0	0.2	0.8	0.8
Taking other prescription medications	0.4	0.7	3.4	-0.2	-1.8	0.2	-0.4	0.6	0.2
Age when periods started (menarche)	0.4	0.8	1.8	0.5	-1.4	-0.2	1.2	0.8	0.9
High blood pressure (mother)	0.4	0.5	1.0	-1.0	-0.7	-0.9	0.8	-0.1	0.6
Past tobacco smoking	0.4	0.7	1.2	-0.9	1.1	0.1	0.8	0.7	0.9
Pain all over the body in last month	0.4	0.5	1.0	-0.9	0.4	-0.5	1.0	0.6	0.5
Diabetes (self-reported)	0.4	0.7	1.3	-1.0	-0.1	0.3	-1.1	-1.0	-0.9
Falls in the last year	0.4	0.5	1.1	-0.1	0.2	1.1	-0.5	-1.1	-0.9
Medication: Lansoprazole	0.4	0.5	1.8	1.3	0.5	-0.0	0.7	0.5	0.0
Prospective memory result	0.4	0.4	1.4	-0.9	-0.2	1.2	0.0	-0.3	-0.5
Impedance of arm (left)	0.4	2.0	4.7	1.1	0.3	-1.0	1.0	2.2	1.9
Eye problems/disorders: None of the above	0.4	0.5	1.3	-1.2	-0.4	0.5	0.3	-1.0	0.0
Pulse rate, automated reading	0.4	1.2	2.1	-0.9	0.3	0.7	1.2	1.4	1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	1.3	0.9	0.2	-0.5	-0.4	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	2.6	0.4	-1.6	0.4	0.3	0.0	0.4
Smoking status: Previous	0.4	0.6	1.6	1.3	-1.0	-0.4	-0.7	-0.5	-0.5
Medication: Blood pressure	0.4	0.7	3.2	0.3	0.9	-1.8	0.6	-0.2	-0.0
High cholesterol (Self-reported)	0.4	0.7	1.3	0.4	-1.1	-1.0	-0.2	1.0	1.0
Arm fat-free mass (left)	0.4	1.8	3.4	-0.8	-1.0	1.0	-1.5	-1.6	-1.9
Diastolic blood pressure, automated reading	0.4	1.2	3.6	-0.8	0.8	0.2	1.9	0.9	1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.5	1.6	-0.0	-0.3	0.2	0.3	0.5
Bipolar Disorder (2018)	0.3	0.4	1.7	0.6	0.0	-1.3	0.2	0.2	-0.5
Worry (Nagel 2018)	0.3	0.6	2.6	-1.6	-0.6	-0.0	-0.4	0.6	-0.2
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.1	-0.3	-0.5	0.6	0.9	1.0
Ulcerative Colitis	0.3	0.4	1.3	0.4	1.1	-0.6	0.9	0.2	0.1
Waist Hip Ratio (WHR)	0.3	1.5	6.2	2.5	-0.6	-1.2	-0.3	0.7	0.7
Allergy or Eczema	0.3	0.7	1.1	-0.6	1.0	1.1	-0.8	-0.5	-0.8
Number of treatments/medications taken	0.3	0.5	1.6	-0.2	-1.3	-1.0	0.6	-0.4	0.2
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.9	-0.6	-0.9	-0.5	-0.6	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.0	-0.6	0.0	0.3	-1.0	-0.8	-0.4
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-1.0	-1.0	0.7	0.3	0.5	0.1
Impedance of leg (right)	0.3	1.5	2.4	1.0	-0.8	-1.2	1.1	1.5	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	0.6	0.4	-1.4	0.0	-1.2	-0.5
Financial difficulties in last 2 years	0.3	0.4	1.4	-0.6	1.2	-0.1	0.0	0.2	0.6
Impedance of arm (right)	0.3	1.5	3.9	0.1	0.6	-0.4	1.0	2.0	1.9
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.4	-0.7	0.3	-0.7	-0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	1.1	-0.8	-0.6	0.9	-0.1	0.3
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.6	-0.0	-0.3	0.2	1.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.3	1.1	0.6	-0.4	0.8	0.0	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	-0.0	0.5	-0.7	0.4	0.8	0.6
Arm fat-free mass (right)	0.3	1.6	3.4	-0.6	-1.1	0.8	-1.4	-1.4	-1.8
Exposure to tobacco smoke outside home	0.3	0.4	0.9	0.3	-0.3	-0.2	0.6	0.8	1.0
Age at first live birth	0.3	0.6	1.1	1.0	0.6	-1.0	0.6	0.5	0.7
Mean time to correctly identify matches	0.3	0.5	1.0	1.0	0.8	-0.5	0.6	0.7	0.5
Arm predicted mass (right)	0.3	1.7	3.5	-0.4	-1.3	0.8	-1.3	-1.6	-1.9
Alcohol intake frequency.	0.3	0.8	1.2	-1.1	-1.0	0.9	-1.0	-0.8	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.3	-0.6	-0.5	0.5	0.8	0.7
Whole body fat-free mass	0.3	1.7	3.0	-0.9	-1.1	1.1	-1.3	-1.6	-1.7
Leg fat-free mass (right)	0.3	1.8	3.6	-0.6	-0.2	1.3	-1.6	-1.6	-1.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.2	0.5	0.5	-0.7	-0.4	-1.0
Mineral and other dietary supplements	0.3	0.4	1.4	0.0	-0.1	0.4	-0.1	1.2	0.8
Breast cancer (self-reported)	0.3	0.4	1.2	-1.1	0.2	-0.6	0.6	0.4	0.6
Whole body water mass	0.3	1.5	2.8	-0.9	-1.0	0.9	-1.2	-1.5	-1.7
Leg predicted mass (right)	0.3	1.7	3.3	-0.7	-0.3	1.2	-1.6	-1.5	-1.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.3	-0.4	-0.3	0.1	-1.2	-0.8
Number of operations (self-reported)	0.3	0.5	1.4	0.1	-0.3	-0.4	1.2	0.9	0.7
Commuting to job workplace: Cycle	0.3	0.3	0.8	0.2	0.9	-0.7	-0.7	0.4	-0.1
Arm predicted mass (left)	0.3	1.6	3.1	-0.9	-1.0	0.7	-1.3	-1.5	-1.8
Depression (Nagel 2018)	0.2	0.2	0.9	-0.4	1.0	0.3	-0.3	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	1.1	0.2	-0.9	-0.7	-0.2	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.2	0.3	1.0	-1.1	0.5	0.2	0.3
Reaction Time	0.2	0.3	0.7	0.8	0.3	-0.5	0.4	0.6	0.5
Heel T-Score	0.2	1.7	5.0	2.2	0.6	-2.1	0.7	-0.3	0.5
Systolic Blood Pressure	0.2	1.2	2.2	-0.4	0.0	-1.3	1.5	1.0	1.4
Smoking Status	0.2	0.4	0.8	-0.1	-0.8	0.4	-0.9	-0.7	-0.5
Medication: Metformin	0.2	0.3	0.8	-0.9	-0.0	0.8	-0.5	0.1	0.1
Qualifications: CSEs or equivalent	0.2	0.3	0.8	0.5	-0.9	-0.0	0.3	-0.6	-0.2
High blood pressure	0.2	0.4	1.4	-1.2	0.8	-0.3	0.7	-0.0	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.9	0.3	0.9	-0.9	0.0	-0.4
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	-0.1	-0.3	0.5	-0.6	-0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	-0.4	-0.7	-0.3	0.6	0.2	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.3	0.1	1.2	0.5	0.1	0.0	-0.0
Trunk fat-free mass	0.2	1.3	2.0	-1.1	-1.4	0.9	-0.9	-1.2	-1.4
Number of live births	0.2	0.3	0.8	-0.6	-0.9	-0.3	-0.3	-0.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	-0.3	-0.7	-0.8	1.0	0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	0.9	0.5	-0.7	0.2	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.0	-0.6	-0.3	-0.9	1.0	0.7	0.8
Trunk predicted mass	0.2	1.4	2.4	-1.2	-1.6	0.8	-0.8	-1.2	-1.3
Breastfed as a baby	0.2	0.2	0.6	0.2	-0.4	0.6	-0.0	0.6	0.8
Birth weight of first child	0.2	0.4	1.1	-0.7	1.1	-0.1	-0.3	-0.6	-0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.7	-0.8	0.2	0.4	-0.1	-0.3
High blood pressure (siblings)	0.2	0.3	1.3	-0.0	-1.2	-0.5	0.6	0.3	0.1
Comparative body size at age 10	0.2	0.6	2.1	-0.6	1.4	0.3	0.6	-0.4	-0.7
Number of full sisters	0.2	0.3	0.8	-0.0	-0.6	0.2	-0.5	-0.9	-0.6
Suffer from ‘nerves’	0.2	0.3	1.2	0.3	0.2	-0.7	0.1	1.1	0.5
Chest pain or discomfort	0.2	0.2	1.0	0.1	-0.2	0.2	-1.0	-0.3	-0.5
Age at last live birth	0.2	0.2	0.7	0.9	-0.2	-0.8	-0.1	-0.1	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.4	-0.5	0.4	-0.5	-0.3	-0.6
Hearing aid user	0.2	0.3	0.9	0.6	-0.2	-0.3	-1.0	-0.2	-0.1
Financial situation satisfaction	0.2	0.2	1.0	-0.1	0.2	-0.2	1.0	0.0	0.0
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.3	0.5	0.8	-0.5	-0.5	-0.6
Risk taking	0.2	0.2	0.7	0.0	0.8	0.1	0.8	-0.3	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.1	0.0	-1.1	-0.2	0.2	0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	1.0	-0.1	0.9	-0.8	-0.5	-0.2
Supplements: Calcium	0.2	0.2	0.8	0.5	-0.3	-0.9	0.1	0.2	0.3
Blood Platelet Count	0.1	0.9	4.7	-0.3	-0.5	2.2	-0.3	-0.1	-0.6
Blood Red Count	0.1	1.2	2.6	1.0	-0.2	-0.3	1.6	1.6	1.0
Lung FVC	0.1	0.6	1.8	-0.2	0.4	-0.6	1.4	0.5	0.9
Hand grip strength (left)	0.1	0.2	0.4	-0.4	-0.3	-0.1	0.3	0.6	0.5
Hand grip strength (right)	0.1	0.4	1.0	-0.6	0.1	-0.5	0.3	1.0	0.7
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.1	-0.1	-0.5	0.7	0.4	0.5
Nervous feelings	0.1	0.2	1.0	0.0	-1.0	-0.6	-0.1	-0.0	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.1	-0.3	-0.4	-1.0	-0.0	-0.4
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.8	-1.0	0.1	0.4	0.1	0.0
Worrier / anxious feelings	0.1	0.1	0.5	-0.7	-0.3	0.2	-0.1	-0.1	-0.3
Standing height	0.1	0.8	2.7	0.3	-1.6	-0.5	0.2	1.1	0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	0.2	-0.7	-0.5	0.3	-0.0	0.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	-0.7	-0.6	-0.2	0.6	0.3	0.4
Qualifications: College or University degree	0.1	0.2	1.0	0.1	-0.3	0.4	-1.0	-0.0	-0.3
Comparative height size at age 10	0.1	0.3	0.7	0.8	0.6	-0.4	-0.7	0.5	-0.1
Hypertension (Self-reported)	0.1	0.3	0.7	-0.9	0.1	-0.1	0.1	-0.6	-0.8
Loneliness, isolation	0.1	0.2	0.4	-0.5	-0.4	0.0	-0.5	-0.6	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	1.0	-0.4	-1.0	0.2	0.1	0.2	0.3
Mother’s age at death	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.6	-0.2	-0.4
Medication: Lisinopril	0.1	0.1	0.7	-0.3	0.0	-0.8	-0.2	-0.1	-0.2
Illnesses of father: High blood pressure	0.1	0.2	0.4	-0.7	0.2	0.3	-0.3	-0.4	-0.5
Ever smoked	0.1	0.2	0.6	0.8	-0.1	0.3	-0.1	-0.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.4	0.5	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.6	1.5	0.9	-1.2	-0.1	-1.0	0.2	0.2
Cardiovascular Disease	0.0	0.2	0.4	-0.2	-0.7	-0.3	0.4	0.5	-0.0
Hypothyroidism (self reported)	0.0	0.1	0.2	0.3	-0.1	-0.3	0.2	-0.4	-0.1
Hair Pigment	0.0	0.9	4.8	-0.5	-2.2	-0.6	0.2	-0.5	-0.3
Tanning	0.0	0.2	0.7	-0.2	0.8	0.4	0.0	0.1	-0.0
Current tobacco smoking	0.0	0.1	0.2	-0.5	-0.1	0.3	0.1	-0.2	-0.1
Sitting height	0.0	0.3	1.0	-0.1	-0.4	0.3	0.0	1.0	0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	0.5	-0.2	-0.1	0.3	-0.2
Birth weight	0.0	0.0	0.1	-0.3	-0.2	0.1	0.1	0.1	-0.1
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	0.1	-0.4	-0.1	0.3	0.2	-0.1
Smoking status: Current	0.0	0.1	0.1	-0.3	-0.4	0.3	-0.1	-0.2	-0.1

Hub : Genes

UNC5CL

Models

Trait associations