Hub : Genes

OLFML3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.5520	0.1030	3.5e-04	-0.006	NA	-0.004	NA	0.031	4.6e-01	NA	4.0e-01	NA	6.2e-02
2	GTEx	Cells Transformed fibroblasts	0.1180	0.0470	4.5e-03	-0.003	NA	0.000	NA	-0.002	5.7e-01	NA	3.0e-01	NA	5.6e-01
3	GTEx	Esophagus Gastroesophageal Junction	0.3360	0.1010	1.1e-04	0.015	NA	0.070	NA	0.046	9.0e-02	NA	1.5e-03	NA	9.2e-03
4	GTEx	Esophagus Muscularis	0.3010	0.0660	7.2e-07	0.238	NA	0.220	NA	0.233	1.3e-14	NA	1.6e-13	NA	2.8e-14
5	METSIM	Adipose	0.0658	0.0244	2.2e-04	0.008	0.013	0.006	0.011	0.010	1.9e-02	0.00410	4.0e-02	7.7e-03	9.7e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.0990	0.0341	1.5e-04	0.025	0.027	0.038	0.037	0.027	3.4e-04	0.00019	9.8e-06	1.3e-05	1.8e-04
7	TCGA	Prostate Adenocarcinoma	0.0364	0.0207	7.9e-03	0.002	0.019	0.007	NA	0.008	1.9e-01	0.00430	6.0e-02	NA	4.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.2	0.6	1.1	0.3	1.1	0.2	-1.1	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.8	5.1	-0.9	2.2	0.9	-0.0	-0.1	-2.3	-1.0
Depressed Affect (Nagel 2018)	0.3	0.7	1.7	0.7	-0.7	1.0	1.3	-0.9	-0.1	0.3
Depression (Nagel 2018)	0.6	0.9	2.9	0.3	1.3	0.7	1.1	-1.7	-0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.2	1.1	-0.8	-0.4	-0.5	1.5	2.0	0.7
Neuroticism (Nagel 2018)	0.2	0.5	2.2	0.6	-0.4	-0.5	-0.2	-1.5	0.4	-0.4
Schizophrenia (2018)	0.9	1.8	4.1	-1.6	1.8	0.9	-0.9	-0.3	-2.0	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	1.2	-0.6	0.1	0.9	0.0	0.2	1.4
Worry (Nagel 2018)	0.8	1.8	5.0	-0.5	0.0	-1.6	-1.2	-2.2	-0.9	-1.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.8	-0.0	0.3	-0.1	1.3	0.0	-0.2	0.8
Alzheimer’s Disease (in father)	0.6	0.7	1.8	-0.9	-1.3	0.8	-0.3	0.7	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	2.5	-1.6	-1.2	0.3	0.3	0.5	-0.0	0.1
Crohns Disease (2017)	1.9	4.2	8.9	0.0	2.6	-2.1	0.4	2.2	3.0	2.0
Irritable Bowel Disease (IBD)	0.8	1.9	4.9	0.3	1.2	-2.2	0.7	1.5	1.6	1.2
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.1	-0.7	-0.8	1.0	0.5	-0.4	0.6
Major Depression (MDD)	0.8	1.0	3.5	1.9	-0.1	-0.9	0.2	0.2	-0.8	-1.3
Reaction Time	0.7	1.4	4.5	-0.0	-0.4	-1.8	-0.2	1.1	2.1	0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.8	0.2	-1.2	-1.3	-0.8	1.4	0.6	-0.1
Breast Cancer	2.1	5.0	9.9	-1.9	2.6	-2.7	-0.0	2.4	3.1	1.2
Ovarian Cancer	0.7	0.9	2.5	1.6	1.2	-0.9	0.2	-1.3	0.2	-0.4
Prostate Cancer	0.5	0.7	3.3	-1.8	0.0	0.3	0.5	0.2	0.5	0.8
Age at First Birth	0.3	0.4	1.3	-0.0	-1.1	-0.8	0.5	-0.8	-0.5	-0.2
Bipolar Disorder (2011)	1.9	1.8	5.9	0.3	-0.3	0.9	-0.6	-0.5	-2.4	-2.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	0.6	-0.9	1.2	1.4	0.3	0.5	0.9
Coronary Artery Disease (CAD)	0.8	1.0	3.2	1.1	-1.0	0.6	0.5	-0.3	-1.8	-0.8
Crohns Disease (2012)	1.8	2.9	7.2	-0.4	1.2	-0.8	1.0	1.7	2.7	2.6
Mean Putamen Volume	1.0	1.1	3.8	0.6	1.1	-2.0	0.6	0.4	1.1	0.7
Fasting Glucose	1.4	1.7	4.0	0.6	0.0	-0.0	1.5	2.0	1.2	2.0
HbA1C	0.4	0.4	1.2	0.1	0.5	1.1	-0.1	-0.9	-0.8	-0.3
HDL Cholesterol	0.4	0.7	2.8	-1.7	-0.3	0.7	-0.3	0.0	1.2	0.6
LDL Cholesterol	0.9	1.5	4.0	1.4	-0.5	0.9	0.9	-2.0	-1.4	0.4
Lupus	1.9	2.9	9.0	-0.4	-2.9	0.7	0.7	-0.9	-3.0	-0.8
Neuroticism (2016)	0.2	0.3	1.0	-0.4	0.1	-0.5	-1.0	-0.2	0.7	-0.1
Primary Biliary Cirrhosis	0.8	1.1	2.1	1.4	-1.2	-0.6	1.3	0.7	0.6	1.1
Rheumatoid Arthritis	22.8	31.4	100.0	3.1	-7.3	4.6	4.3	-4.0	-10.0	-1.2
Schizophrenia (2014)	0.4	1.0	4.3	-0.9	1.0	0.2	-0.1	-0.1	-2.1	-0.8
Triglycerides	0.4	0.6	2.1	-0.1	0.3	0.1	-0.4	-1.0	-1.5	-0.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	1.9	0.9	-1.4	-1.2	1.4	0.7	-0.1	0.6
Ulcerative Colitis	0.7	1.0	2.5	-0.3	-1.6	-0.2	1.4	-1.0	-1.1	0.3
Blood Eosinophil Count	0.1	0.8	2.1	0.4	1.5	-0.2	0.1	1.1	0.9	1.2
Blood Platelet Count	0.2	2.8	8.9	0.2	2.9	-1.4	-0.3	-3.0	-0.4	-0.4
Blood Red Count	0.3	2.5	7.5	-2.4	-2.7	-0.2	0.7	-0.8	-1.6	0.0
Blood White Count	2.6	19.4	84.6	-1.8	9.2	-3.9	-1.7	2.5	4.7	1.2
Heel T-Score	1.6	12.9	35.6	-3.8	1.8	-1.4	-6.0	-1.3	-2.2	-5.4
BMI	0.3	1.5	4.1	0.3	0.9	0.9	-0.9	-2.0	-1.3	-1.4
Height	0.0	0.8	2.0	1.4	-0.3	-1.4	-0.6	0.7	0.5	-0.7
Waist Hip Ratio (WHR)	0.5	2.3	6.8	-0.9	-2.6	-1.0	1.6	1.2	-0.6	1.7
Systolic Blood Pressure	0.3	1.3	4.4	0.2	0.3	-0.4	2.0	-0.2	-0.7	2.1
Smoking Status	1.2	3.0	10.4	-0.3	0.9	-1.5	1.5	3.2	1.4	1.7
Allergy or Eczema	0.9	2.3	6.5	-2.5	2.5	0.1	-1.7	-0.3	0.6	-0.1
Cardiovascular Disease	0.3	1.0	4.3	-0.4	0.5	0.8	0.4	-2.1	-1.2	0.6
Hypothyroidism (self reported)	21.5	49.3	153.8	2.6	-10.1	6.2	3.7	-3.5	-12.4	-4.1
Respiratory disease	0.6	1.4	6.0	-0.5	-0.6	-0.1	1.5	-0.8	-2.5	-0.0
Type 2 Diabetes (T2D) (2018)	1.7	3.2	7.2	0.5	-1.7	2.7	1.7	-2.2	-1.4	1.5
Lung FEV1/FVC ratio	0.4	1.9	4.3	-0.8	2.1	0.6	-0.2	1.8	1.9	1.0
Lung FVC	0.5	2.7	6.7	0.3	-1.6	2.6	1.6	-0.9	-2.4	0.4
Neuroticism	0.2	0.6	1.8	0.2	-1.1	0.0	0.8	-1.4	0.2	0.2
Chronotype (morning person)	1.1	2.6	5.0	1.9	0.6	2.2	2.0	-1.7	0.7	1.5
Hair Pigment	0.1	1.7	6.8	1.2	0.2	1.2	0.9	-2.6	-1.0	-0.4
Tanning	0.2	2.2	5.6	-0.6	-0.5	-2.1	-0.1	2.4	1.5	1.7
Hand grip strength (left)	1.1	2.9	10.9	0.6	-0.0	-1.2	1.5	3.3	1.3	1.9
Number of treatments/medications taken	3.1	5.5	11.6	3.1	-1.2	3.0	2.0	-3.4	-1.5	-0.1
Average weekly spirits intake	1.1	1.4	2.9	1.3	-0.7	-0.0	1.0	1.0	1.7	1.6
Sensitivity / hurt feelings	0.4	0.7	3.7	0.4	-0.8	0.2	-0.7	-0.1	1.9	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	0.6	0.4	0.6	1.0	-1.4	0.8	0.4
Hearing difficulty/problems: Yes	0.6	1.0	1.8	1.3	0.8	1.4	1.3	0.5	-0.6	-0.4
Relative age of first facial hair	0.4	0.8	2.0	-0.3	1.4	0.6	-0.5	-0.8	1.4	0.3
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	7.0	2.5	-2.5	1.3	2.6	0.4	-1.6	0.6
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.2	0.1	0.3	-1.2	0.4	0.9	2.1	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-1.4	0.5	0.3	-0.0	1.2	0.8	1.0
Systolic blood pressure, automated reading	0.9	2.6	8.5	0.8	1.0	-0.3	2.5	0.7	1.2	2.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	-0.5	-0.3	0.5	-0.9	-1.2	-1.4	-1.1
Angina	0.9	1.2	4.8	0.7	-1.5	0.7	0.1	-0.3	-2.2	-0.2
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.5	-0.6	-0.5	-0.8	-0.2	-0.4	-0.4
Vitamin and mineral supplements	0.4	0.6	1.5	0.1	-1.2	0.8	0.0	-0.9	0.8	0.6
Supplements: Zinc	1.0	1.1	2.9	0.1	1.0	0.9	1.7	1.0	-1.0	1.0
Medication: Co-codamol	0.5	0.6	1.5	0.5	0.8	0.3	-0.8	1.0	1.2	-0.2
Medication: Metformin	0.6	0.8	4.0	-0.1	-0.7	0.3	-0.8	-2.0	-0.6	-0.5
Diabetes (father)	0.4	0.6	2.4	0.4	-0.2	-0.4	0.3	-1.6	-1.0	0.0
Diabetes (mother)	0.9	1.1	2.2	-1.1	-1.4	-1.5	0.4	-0.2	1.0	0.9
Severe depression (siblings)	0.7	0.8	3.5	1.9	0.1	-1.0	0.7	0.0	-0.9	0.0
Pack years adult smoking proportion	0.1	0.1	0.4	0.3	-0.1	-0.2	0.7	-0.6	-0.1	0.2
Impedance of leg (right)	0.2	1.0	2.2	-1.4	0.5	-1.4	-0.3	0.5	1.5	0.2
Leg fat-free mass (left)	0.1	0.6	1.3	0.9	1.0	0.3	-1.1	0.3	-0.9	-0.6
Trunk fat percentage	0.7	2.9	6.5	-0.7	2.0	-0.9	-2.6	-1.8	0.4	-2.3
Hand grip strength (right)	0.3	0.8	2.7	0.0	-0.8	-0.9	0.9	1.6	0.3	0.9
Townsend deprivation index at recruitment	1.8	2.5	6.1	-1.4	1.7	-0.6	-1.0	-2.5	-1.5	-1.8
Current tobacco smoking	1.0	1.7	3.8	0.9	1.3	-1.6	1.1	1.9	1.1	0.8
Average weekly fortified wine intake	0.4	0.5	1.0	-0.1	0.6	-0.9	-0.3	1.0	0.8	0.6
Maternal smoking around birth	0.4	0.5	2.5	-0.5	0.8	-1.6	0.2	0.1	0.2	0.5
Fed-up feelings	0.5	0.8	2.7	1.6	0.6	0.6	1.0	-1.1	0.3	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	4.5	0.5	0.4	-0.7	0.5	-2.1	0.2	-0.8
Relative age voice broke	0.1	0.1	0.4	0.4	0.1	-0.6	-0.1	-0.5	0.5	-0.1
Taking other prescription medications	3.0	4.6	9.5	1.6	-3.1	2.4	1.0	-2.7	-2.4	-0.5
Age when periods started (menarche)	1.3	3.2	14.4	0.7	1.9	-0.9	-1.1	0.8	3.8	0.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	5.2	-1.6	-0.4	-2.3	-1.2	-0.6	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.1	7.9	-2.0	1.7	-2.4	-2.8	-0.8	-0.6	-2.7
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.2	2.5	-0.1	-0.0	2.0	0.3	-0.7	1.2
Qualifications: CSEs or equivalent	0.6	0.8	1.8	0.2	-0.6	0.4	-1.2	-1.3	-0.8	-1.2
Serious illness, injury or assault to yourself	1.8	2.1	8.4	2.0	-1.1	-0.2	1.0	-2.9	-0.6	-0.3
High blood pressure	0.5	1.4	4.5	1.2	1.5	-0.8	0.5	-2.1	0.6	0.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.9	-2.2	2.6	-0.3	-1.7	0.1	-0.0	-0.3
Multivitamins +/- minerals	0.9	1.1	2.6	-0.5	1.6	-1.3	0.2	0.4	-1.3	-1.0
Stomach or abdominal pain in last month	0.5	0.7	1.8	0.0	-0.2	0.9	0.2	-0.7	-1.3	-1.2
Supplements: Glucosamine	1.3	1.7	4.3	1.1	1.5	-0.9	1.2	0.3	2.1	1.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.4	0.6	-0.7	-0.7	0.5	-0.5	1.9	0.1
Medication: Atenolol	0.9	1.1	3.3	1.8	0.0	0.7	1.3	-0.8	0.2	1.3
Medication: Levothyroxine sodium	12.2	20.7	54.8	2.0	-6.7	4.9	1.2	-2.7	-7.4	-2.8
Sitting height	0.2	1.2	4.5	2.1	-1.6	-0.4	0.7	0.4	-0.8	0.4
Chronic bronchitis/emphysema (father)	1.5	1.8	4.2	1.7	-0.3	-1.1	1.1	1.0	2.1	1.4
High blood pressure (mother)	0.8	1.2	2.8	1.4	-0.3	1.0	1.2	1.0	-0.2	1.7
Body mass index (BMI)	0.4	1.6	4.3	0.5	2.1	0.4	-1.5	-1.1	-0.7	-1.7
Impedance of leg (left)	0.2	1.1	4.2	-1.2	-0.1	-2.0	-0.4	0.0	1.2	-0.1
Leg predicted mass (left)	0.1	0.7	1.3	0.9	1.0	0.4	-1.1	0.2	-0.9	-0.7
Trunk fat mass	0.6	2.5	5.9	-0.2	2.2	-0.9	-2.4	-1.3	0.4	-2.1
Waist circumference	0.3	1.2	2.9	-0.2	1.7	-1.1	-1.4	-0.1	-0.3	-1.5
Number of incorrect matches in round	0.4	0.7	2.3	-0.3	-1.2	-0.0	-0.1	0.4	-1.1	-1.5
Past tobacco smoking	1.0	1.8	5.2	-0.8	-0.7	1.2	-0.2	-2.3	-1.9	-1.2
Alcohol usually taken with meals	1.7	2.8	6.7	-0.4	0.7	2.0	-0.9	-1.9	-2.6	-2.0
Nervous feelings	0.3	0.5	1.1	0.3	-0.7	-1.0	0.3	-0.9	-1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.1	1.2	0.4	1.8	1.4	-1.5	-0.1	0.3
Hearing difficulty/problems with background noise	1.2	1.9	4.8	1.7	0.1	1.3	2.2	0.4	1.1	1.6
Hair/balding pattern: Pattern 2	0.4	0.6	2.2	-0.1	1.5	-0.1	-0.2	0.2	1.1	0.7
Had menopause	1.1	1.4	2.5	-0.1	1.4	-1.5	-0.1	1.6	1.6	-0.1
Had other major operations	1.4	1.7	6.6	0.6	1.9	2.6	-0.3	-0.9	0.3	0.2
Forced vital capacity (FVC)	0.5	2.1	7.9	1.4	-2.8	0.9	1.3	-0.4	-1.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	6.2	-1.1	0.8	-2.2	-2.4	-0.9	-1.3	-2.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.7	0.9	-0.4	-0.7	1.9	0.7	0.1	1.4
Qualifications: None of the above	0.7	1.4	4.6	0.5	1.1	-1.7	0.6	-2.1	0.7	-0.2
Financial difficulties in last 2 years	0.5	0.6	2.1	-0.6	1.0	-0.4	1.4	-0.8	-0.4	0.4
Mouth/teeth dental problems	1.6	2.5	5.2	-1.5	2.3	-0.0	-1.8	1.8	1.9	0.7
Heart attack	1.7	2.2	7.3	-0.1	-0.7	1.4	0.2	-1.6	-2.7	-1.6
Allergy	0.8	1.8	5.1	2.3	-1.5	0.9	1.7	0.9	0.5	0.6
Pain all over the body in last month	1.5	1.6	5.8	0.4	0.3	2.0	1.0	-2.4	-0.1	0.7
Diabetes (self-reported)	1.6	2.5	8.4	0.0	-1.3	1.6	0.4	-2.9	-2.2	0.0
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	6.3	-1.6	2.5	-0.4	-1.1	0.8	-1.0	0.0
Medication: Ramipril	2.0	2.6	10.8	-0.3	-0.5	-0.8	-1.0	-3.3	-1.9	-1.3
Medication: Simvastatin	0.7	1.1	4.8	0.3	-0.0	-0.6	-0.9	-2.2	0.7	-1.0
Fluid intelligence score	0.4	0.9	4.0	-0.3	-2.0	-1.0	0.6	0.8	-0.3	0.3
Illnesses of siblings	0.3	0.4	1.0	-0.8	-0.9	0.4	-0.2	1.0	-0.5	-0.3
Neuroticism score	0.2	0.4	1.8	0.7	-0.4	-0.1	0.0	-1.4	0.3	-0.4
Weight	0.3	1.3	3.3	0.7	1.6	-0.5	-1.8	-0.4	-0.1	-1.5
Impedance of arm (right)	0.4	1.6	6.2	-2.5	-1.4	-0.8	-0.4	1.0	1.3	0.2
Arm fat percentage (right)	0.4	1.7	4.3	-0.3	1.5	0.2	-2.1	-0.9	-0.4	-2.0
Trunk fat-free mass	0.2	1.3	4.4	2.1	1.2	-0.0	-0.1	1.5	0.5	0.7
Hip circumference	0.8	3.6	10.6	0.0	3.3	-0.5	-2.5	-0.6	-0.5	-2.7
Time employed in main current job	0.6	0.6	3.5	1.9	0.2	0.2	-0.0	0.6	0.7	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	2.1	0.2	-0.2	0.2	1.3	1.4	-0.3	0.6
Father’s age at death	0.4	0.5	2.1	-0.8	0.7	-0.2	-0.4	1.4	0.5	0.3
Worrier / anxious feelings	0.8	1.6	3.2	-1.0	1.3	-0.7	-1.8	-1.3	-0.3	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	7.0	2.6	-1.0	1.4	1.9	-2.6	0.2	0.4
Falls in the last year	0.2	0.3	1.2	0.3	0.2	0.5	0.3	-1.1	0.7	0.2
Hair/balding pattern: Pattern 3	1.1	1.6	3.6	1.3	-1.9	-0.2	1.4	1.5	0.3	1.1
Number of live births	1.7	2.4	7.5	-1.2	1.3	-1.2	-2.7	-0.8	0.3	-1.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.8	0.6	-1.7	0.9	0.3	-0.6	-1.1	-0.2
Pulse rate	0.3	0.4	1.5	0.6	-0.2	-0.9	-0.3	0.5	1.2	-0.1
Happiness	0.1	0.1	0.3	0.1	0.6	0.3	-0.4	-0.4	-0.1	-0.5
Noisy workplace	0.5	0.6	2.1	-0.2	0.8	0.1	0.9	-1.5	-0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.4	-0.7	-0.4	1.7	0.1	2.1	0.2	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	1.1	-0.6	-0.2	-0.2	-1.1	-0.1	0.0
Mouth/teeth dental problems: Dentures	1.4	2.3	5.4	1.0	-2.2	0.7	2.3	1.2	-1.7	-0.1
Asthma	0.6	1.2	4.3	-1.2	-0.5	0.4	1.1	0.6	-2.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	5.5	2.4	-0.3	1.3	1.8	0.4	0.3	1.3
Medication: Cholesterol lowering	1.7	2.6	7.3	0.3	0.7	2.3	1.6	-2.7	-1.6	-0.1
Depression (self-reported)	1.4	1.6	4.3	2.1	0.3	0.0	1.8	0.5	1.0	1.6
Medication: Lansoprazole	0.5	0.5	1.6	0.6	-1.0	0.3	0.3	-1.3	0.2	-0.7
Prospective memory result	0.9	1.1	3.5	-1.9	1.6	-0.6	-0.9	-0.5	0.5	-0.3
Lung cancer (father)	0.3	0.3	1.0	0.9	-0.4	-0.2	0.3	-0.5	0.3	1.0
Illnesses of mother	0.6	0.7	1.6	-1.0	0.4	-0.7	-1.1	-1.3	0.0	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.1	0.1	-1.1	2.0	0.4	-0.7	-1.2	0.1
Pulse wave Arterial Stiffness index	2.5	3.0	11.2	1.4	0.4	-0.7	0.2	2.0	3.3	1.7
Impedance of arm (left)	0.4	2.0	9.9	-3.1	-1.0	-0.9	-1.1	-0.3	0.9	-0.6
Arm fat mass (right)	0.4	1.5	4.4	0.3	1.7	0.0	-2.1	-0.7	-0.1	-1.7
Trunk predicted mass	0.2	1.3	4.5	2.1	1.1	0.0	-0.1	1.5	0.6	0.8
Standing height	0.2	1.5	4.0	0.6	-0.6	-2.0	-0.9	1.7	1.4	0.2
Length of working week for main job	0.5	0.6	1.9	1.4	-0.1	-0.9	0.3	0.2	0.9	0.8
Exposure to tobacco smoke at home	0.5	0.5	2.1	0.9	1.4	-0.3	-0.3	0.0	-0.4	-0.5
Breastfed as a baby	0.4	0.5	1.3	0.8	0.7	-0.4	-1.2	0.2	0.3	-1.0
Tense / ‘highly strung’	1.3	2.2	9.6	-1.2	0.8	-1.3	-0.9	-3.1	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.0	-0.5	-0.2	-2.0	-0.2	1.0	-0.2	-0.3
Hair/balding pattern: Pattern 4	0.4	1.0	2.1	-1.0	-1.0	-0.4	-0.7	-1.3	-0.3	-1.4
Birth weight of first child	1.0	1.8	6.3	0.6	0.8	-1.0	-0.6	2.0	2.5	0.4
Peak expiratory flow (PEF)	0.5	1.2	2.8	-1.6	-0.5	0.1	-1.7	0.9	-0.9	-0.9
Pulse wave reflection index	1.3	1.6	4.1	1.4	0.5	-0.2	0.3	2.0	1.7	1.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.9	0.5	-0.3	-0.4	1.4	-2.0	-0.4	-0.2
Loud music exposure frequency	2.7	3.0	8.3	2.7	-0.2	1.5	2.9	0.2	-0.6	1.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	3.0	0.1	-1.0	0.3	-0.8	1.7	0.6	0.4
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	19.4	0.3	-0.6	-0.8	-0.8	-4.4	-1.9	-1.8
Blood clot in the leg (DVT)	1.1	1.5	4.8	-0.9	-0.6	-2.2	-1.0	-1.2	1.1	-0.8
Medication: Paracetamol	1.4	2.3	9.7	-0.9	1.4	3.1	0.2	-1.7	-0.6	-0.3
Headache pain in last month	1.0	1.8	6.8	0.5	0.2	2.6	1.5	-1.3	-1.0	0.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	6.1	-0.9	-0.1	-1.6	-2.2	2.5	1.4	-0.7
Glaucoma (self-reported)	0.7	0.8	2.2	1.5	0.1	0.2	1.2	-1.3	0.3	0.6
Gout (self-reported)	0.1	0.1	0.5	-0.2	0.2	-0.2	-0.4	0.7	0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	16.8	32.7	102.0	1.7	-8.2	5.3	1.5	-3.1	-10.1	-4.1
Medication: Amlodipine	0.8	1.1	2.5	0.8	-0.2	1.4	1.2	-1.2	-1.6	0.4
Medication: Ventolin 100micrograms inhaler	2.5	3.2	7.0	-1.9	-2.6	-0.2	1.8	1.2	-0.4	2.6
Birth weight	0.5	1.1	3.5	0.7	-0.8	-1.0	-0.8	1.9	1.2	0.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.7	1.1	1.9	-1.1	-0.7	-1.8	0.5	-0.5
High blood pressure (siblings)	1.0	1.5	4.2	2.0	1.2	-0.7	0.5	0.7	1.5	1.2
Forced vital capacity (FVC), Best measure	0.4	1.6	4.1	0.4	-1.9	2.0	1.0	-0.3	-1.4	0.5
Body fat percentage	0.8	3.2	6.7	-0.7	2.1	-0.8	-2.6	-1.9	0.0	-2.6
Leg fat percentage (right)	0.8	2.8	7.2	-0.3	2.7	-0.8	-2.0	-1.6	-0.0	-2.3
Arm fat-free mass (right)	0.2	0.8	2.4	1.4	1.6	-0.2	-1.0	0.2	-0.1	-0.3
Exposure to tobacco smoke outside home	1.2	1.6	3.2	1.5	-0.3	-1.8	1.7	0.9	-0.8	1.1
Comparative body size at age 10	0.4	1.0	4.4	0.3	-1.0	-0.6	0.8	2.1	-0.7	0.2
Number of full brothers	0.2	0.3	0.8	0.9	0.9	0.2	-0.1	-0.4	0.6	-0.4
Worry too long after embarrassment	1.7	2.9	5.6	-2.2	0.2	-2.3	-2.4	-0.1	2.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	6.7	-0.3	-0.0	-2.6	0.6	0.7	0.8	-0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.7	0.2	-0.9	0.6	0.4	-0.2	0.3
Number of children fathered	1.4	1.6	3.7	1.7	-1.6	0.1	1.9	1.3	0.3	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.7	0.2	-1.6	0.6	1.1	1.6	-0.5	0.3
Age at first live birth	0.6	1.1	4.5	-0.9	-2.1	0.1	-0.2	0.6	0.7	1.2
Pulse wave peak to peak time	2.3	2.7	10.8	-1.5	-0.7	0.6	-0.0	-1.8	-3.3	-1.5
Health satisfaction	1.1	1.4	5.0	2.2	-1.8	0.1	0.6	-0.8	-0.1	-0.7
Shortness of breath walking on level ground	0.4	0.5	2.0	0.3	0.2	0.6	-0.2	-1.0	-0.3	-1.4
Qualifications: College or University degree	0.2	0.6	2.0	-1.4	-0.8	-0.5	0.3	0.5	-0.2	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.6	-0.4	0.3	0.4	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.4	-0.2	0.6	-0.1	0.1	-1.2	-0.2	0.1
Emphysema/chronic bronchitis	1.2	1.3	4.5	2.1	-0.8	0.5	0.3	-1.1	-0.7	-1.3
Medication for pain relief, constipation, heartburn	0.7	1.3	3.8	-1.0	-0.7	-1.9	-0.1	1.6	0.8	0.6
Neck or shoulder pain in last month	0.8	1.1	4.1	1.4	-0.3	0.5	2.0	0.5	0.4	1.0
Medication: Blood pressure	0.8	1.3	5.9	0.6	-0.2	0.3	1.4	-2.4	-0.9	0.5
Angina (self-reported)	1.3	1.7	5.8	0.7	-2.2	0.6	0.4	-0.2	-2.4	-0.2
Migraine (self-reported)	1.9	2.4	4.3	2.1	1.2	1.6	1.6	1.5	1.4	1.4
Medication: Ibuprofen	1.5	1.8	4.1	2.0	-0.4	1.8	1.8	0.1	0.1	1.5
Medication: Allopurinol	0.1	0.1	0.3	0.2	-0.1	-0.4	0.0	0.6	-0.3	-0.4
Medication: Omeprazole	1.5	1.8	4.8	1.1	-0.1	1.4	-1.3	-2.2	-0.9	-1.4
Medication: Seretide 50 evohaler	0.4	0.4	1.3	-0.5	-0.1	-0.5	0.1	-1.1	-1.1	0.0
Mean time to correctly identify matches	1.5	2.9	8.8	0.9	0.7	-1.9	0.1	2.2	3.0	1.1
Heart disease (mother)	0.7	0.9	3.4	0.7	-0.5	0.1	-0.1	-1.8	-1.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.2	0.4	-0.4	1.1	0.4	0.6	0.8	1.0
Whole body fat mass	0.6	2.3	5.4	0.1	2.3	-0.6	-2.3	-1.2	0.2	-1.9
Leg fat mass (right)	0.6	2.3	5.5	0.1	2.4	-0.6	-2.1	-1.1	-0.5	-2.1
Arm predicted mass (right)	0.1	0.7	1.6	1.3	1.3	-0.4	-1.2	0.3	0.1	-0.5
Pulse rate, automated reading	1.0	3.2	8.5	0.3	1.5	0.5	-2.5	-2.9	0.7	-2.2
Alcohol intake frequency.	1.1	2.6	7.5	1.1	-0.9	2.2	1.5	-0.8	-2.7	-1.0
Comparative height size at age 10	0.5	3.0	6.5	1.3	-1.5	-1.2	2.0	2.5	1.0	2.0
Number of full sisters	1.2	1.5	3.1	-0.8	-1.5	1.5	-0.3	-1.1	-1.8	-0.8
Suffer from ‘nerves’	0.3	0.5	1.5	-0.6	-1.2	-0.7	0.8	-0.2	0.5	0.6
Overall health rating	1.7	3.6	10.1	2.7	-0.6	1.6	2.0	-3.2	-0.8	-0.7
Chest pain or discomfort	0.7	1.1	3.2	0.3	0.1	1.4	1.3	-0.2	-1.8	0.6
Had major operations	0.5	0.6	2.0	0.4	-0.1	0.5	1.2	-0.4	0.1	1.4
Age at last live birth	0.8	1.2	2.9	-1.6	-1.7	-1.1	-1.0	0.3	0.7	0.3
Family relationship satisfaction	0.2	0.2	0.7	0.3	-0.2	-0.3	0.8	0.3	0.3	0.5
Leg pain on walking	0.8	1.0	3.6	1.0	-0.1	1.3	0.0	-1.9	-0.4	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-1.0	-0.2	-1.1	-1.4	0.2	1.0	0.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.0	0.1	1.4	-1.7	-1.7	0.6	0.7	-1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	9.2	-0.5	0.3	0.3	0.0	3.0	0.4	0.5
Medication: Aspirin	0.6	0.8	3.4	1.0	0.5	0.7	0.0	0.1	-1.8	-0.8
Supplements: Vitamin C	1.1	1.3	5.1	0.5	-0.1	0.6	1.0	2.2	1.0	1.2
Knee pain experienced in last month	0.5	0.8	3.1	1.1	-1.0	0.4	-0.2	-1.8	0.0	-0.3
Hypertension (Self-reported)	0.5	1.3	4.5	1.2	1.4	-0.5	0.4	-2.1	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	11.3	1.4	-1.2	-0.0	-0.4	-3.4	-1.3	-2.3
Illnesses of father: Heart disease	1.2	1.6	5.7	-0.1	0.9	0.1	-1.2	-2.4	-0.8	-1.6
Illnesses of siblings: Diabetes	1.1	1.3	3.8	-1.2	0.8	1.9	-0.5	-1.0	-1.4	-0.6
Smoking status: Previous	0.5	0.8	2.1	0.5	-0.0	-1.0	-0.5	1.4	1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.3	0.0	-1.5	-0.9	-0.3	-0.1	-0.4	0.1
Whole body fat-free mass	0.1	0.7	3.0	1.7	1.1	0.1	-0.5	0.8	-0.2	0.1
Leg fat-free mass (right)	0.1	0.7	1.8	1.1	0.4	0.4	-0.9	0.0	-1.4	-0.7
Arm fat percentage (left)	0.7	2.8	6.4	-0.8	2.0	0.2	-2.5	-1.6	-0.6	-2.4
Average weekly red wine intake	0.6	0.9	2.2	-0.6	-0.7	1.5	1.0	-0.6	-1.4	0.4
Handedness (chirality/laterality): Left-handed	1.6	2.0	10.6	0.9	-0.6	-3.3	0.3	0.2	-1.0	-0.9
Mood swings	0.9	1.6	7.6	-0.4	0.4	2.8	0.5	-1.5	-0.9	-0.3
Loneliness, isolation	0.5	0.7	3.2	0.5	0.7	1.8	0.6	-0.5	0.1	-0.6
Long-standing illness, disability or infirmity	3.0	4.5	7.5	1.9	-1.5	2.5	2.2	-2.6	-2.7	-0.6
Ever had bowel cancer screening	0.2	0.3	0.9	0.5	0.0	0.3	-0.3	-0.6	1.0	-0.3
Diabetes diagnosed by doctor	1.8	2.9	7.5	0.3	-2.1	1.9	0.4	-2.7	-2.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.0	0.9	-1.4	-0.2	1.0	-1.0	-0.8	0.3
Friendships satisfaction	0.4	0.6	1.3	0.5	0.4	1.0	-0.3	-1.1	-0.8	-0.8
Qualifications: nursing, teaching	0.9	1.4	5.0	0.9	-1.4	1.2	-0.0	0.5	-2.2	0.2
Commuting to job workplace: Walk	2.7	3.0	7.6	2.7	-2.7	-0.9	1.8	1.0	-0.5	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.1	-0.7	-1.0	0.3	0.9	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	0.5	-1.1	-0.3	1.0	0.4	0.6	0.4
Medication for cholesterol	0.4	0.6	1.7	-0.4	-0.8	0.2	0.9	1.3	-0.6	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.1	1.4	1.0	0.4	0.2	0.3	0.1	-0.3
Back pain experienced in last month	0.7	1.1	3.4	0.5	-0.3	0.4	0.1	-1.4	-1.8	-1.2
Mineral and other dietary supplements	1.2	1.7	5.4	-1.7	-2.3	0.9	-0.8	0.6	-1.2	-0.6
Breast cancer (self-reported)	0.7	0.8	1.9	1.1	0.9	-1.4	-1.1	-0.3	0.7	-0.0
Asthma (self-reported)	0.8	1.6	6.3	-1.3	-0.8	0.6	1.2	0.7	-2.5	0.7
Osteoporosis (self-reported)	0.5	0.7	3.2	0.2	-0.4	0.3	0.0	0.6	1.8	0.8
Osteoarthritis (self-reported)	0.9	1.2	4.5	0.7	1.6	2.1	-0.4	0.5	0.9	0.1
Medication: Aspirin	0.6	0.8	3.3	1.0	-0.1	0.8	0.5	0.5	-1.8	-0.4
Medication: Gliclazide	0.9	1.0	3.8	-0.5	-0.8	0.3	1.4	-0.5	-1.9	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.1	-0.3	0.3	0.3	0.4	-0.6	-0.1
Smoking status: Current	1.0	1.5	3.4	0.4	1.3	-1.5	1.2	1.8	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	8.9	0.5	-0.8	3.0	1.1	0.1	-0.7	0.8
Whole body water mass	0.1	0.8	3.3	1.8	1.1	0.1	-0.5	0.9	-0.1	0.1
Leg predicted mass (right)	0.1	0.7	1.9	1.1	0.5	0.3	-0.9	0.1	-1.4	-0.7
Arm fat mass (left)	0.5	2.0	5.0	-0.1	1.9	-0.1	-2.2	-1.0	-0.3	-2.0
Number of self-reported non-cancer illnesses	1.4	2.4	7.7	1.0	-0.0	0.8	1.7	-2.8	-2.2	0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.9	-0.7	-0.9	-0.7	-0.0	-1.4	0.6	0.1
Miserableness	0.3	0.6	2.0	0.7	-0.8	0.4	0.5	-1.4	0.5	0.1
Guilty feelings	1.1	1.7	3.3	0.8	0.3	1.8	1.7	1.0	1.3	1.6
Wears glasses or contact lenses	2.0	2.3	4.9	0.6	-0.5	1.9	2.2	2.1	-0.3	1.4
Ever taken oral contraceptive pill	1.3	1.5	6.0	1.3	0.9	2.4	-0.3	-0.7	-0.7	-0.8
Hearing aid user	1.0	1.2	4.5	-0.4	1.5	-0.3	-0.7	-0.5	-0.7	-2.1
Mother’s age at death	0.5	0.7	3.0	0.1	-0.4	1.0	-0.6	0.1	1.7	0.5
Financial situation satisfaction	0.7	0.8	2.6	1.6	0.7	0.4	1.3	-1.0	-0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	-0.7	0.8	-0.5	-1.1	-0.6	0.4	-1.5
Commuting to job workplace: Public transport	2.4	2.8	11.7	-0.0	0.1	3.4	1.6	-1.2	-1.8	1.0
Eye problems/disorders: Glaucoma	0.5	0.5	2.2	1.0	0.1	0.1	0.7	-1.5	0.0	0.5
Medication: Blood pressure	0.7	1.4	3.1	1.2	1.8	-0.3	-1.3	-0.9	1.7	0.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.7	2.4	0.7	0.6	0.3	1.4	0.9	0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.3	1.2	1.5	-0.9	1.4	0.8	0.9	1.1
High cholesterol (Self-reported)	0.5	1.0	3.5	-1.1	1.2	0.5	-0.6	-1.9	0.2	0.1
Medication: Bendroflumethiazide	1.3	2.0	3.7	0.0	1.9	-1.1	-1.9	-1.5	1.8	-0.3
Medication: Paracetamol	1.7	2.6	11.9	-0.9	1.6	3.5	0.3	-1.7	-0.2	0.0
Medication: Lisinopril	1.1	1.5	4.4	0.5	0.5	-2.1	-0.8	-1.1	1.9	0.0
Medication: Atorvastatin	0.5	0.6	1.3	-1.0	-0.5	0.8	0.5	-0.8	-1.1	-0.3
Illnesses of father: High blood pressure	1.1	1.4	6.0	0.8	-0.8	0.5	1.1	-0.3	1.0	2.4
Alcohol drinker status: Never	2.1	2.5	10.6	0.3	0.0	3.3	2.1	0.5	-0.5	1.3
Ever smoked	1.6	2.9	12.3	0.6	-0.1	-1.3	1.0	3.5	1.3	1.7
Basal metabolic rate	0.1	0.7	2.6	1.6	1.2	0.0	-0.8	0.6	-0.3	-0.3
Leg fat percentage (left)	0.8	2.7	5.8	-0.3	2.3	-0.9	-1.9	-1.8	-0.2	-2.4
Arm fat-free mass (left)	0.1	0.8	3.3	1.8	0.8	-0.4	-0.6	0.9	0.3	-0.0
Number of operations (self-reported)	0.8	1.2	2.9	1.7	0.7	1.5	0.3	-1.6	0.3	0.4
Average weekly beer plus cider intake	1.3	1.9	4.7	0.1	0.4	-1.0	0.8	2.2	1.5	2.2
Irritability	0.7	1.2	3.9	2.0	-0.0	0.1	-0.3	-1.7	-1.0	-0.0
Risk taking	1.3	1.9	5.1	-0.4	1.5	2.3	-0.2	-1.4	-1.7	-0.9
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.3	0.6	0.8	1.0	0.6	-0.1	-1.1	-0.9
Fractured/broken bones in last 5 years	1.4	1.8	7.9	0.3	1.1	2.8	0.0	0.1	1.3	1.4
Age started oral contraceptive pill	0.6	0.8	2.8	-1.5	0.1	1.7	-0.2	0.5	-0.1	-0.3
Diastolic blood pressure, automated reading	0.6	1.8	5.6	-0.2	1.1	-0.6	1.0	-0.8	1.8	2.4
Ever depressed for a whole week	0.8	1.0	2.1	1.4	-0.1	-0.5	1.4	0.3	1.4	0.7
Unable to work because of sickness or disability	0.3	0.3	1.6	-0.3	-0.1	0.3	1.2	-0.1	-0.1	0.8
Commuting to job workplace: Cycle	0.4	0.5	1.3	-0.3	-1.1	-0.3	0.5	0.5	-1.0	-0.5
Myopia	1.8	2.6	10.5	-0.3	-2.2	0.2	3.2	0.6	-1.3	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.5	-1.2	-0.9	0.3	-0.9	1.9	-0.1	-0.8
Cholesterol lowering medication	0.5	0.8	1.8	0.1	-0.3	-1.1	-1.2	-0.7	1.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	4.8	-0.3	0.2	0.9	-2.0	-2.2	-0.7	-1.7
Pain experienced in last month	1.0	1.7	4.6	0.7	0.4	-0.4	0.9	2.1	1.4	1.8
Supplements: Calcium	0.3	0.3	1.4	-0.1	1.2	0.5	0.2	-0.4	-0.1	0.7
Basal cell carcinoma (self-reported)	1.6	1.9	8.3	-0.4	1.1	-1.0	-1.3	-0.9	2.9	-0.3
Heart attack/myocardial infarction (self-reported)	1.6	2.0	6.8	0.4	-1.0	1.3	0.5	-1.6	-2.6	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	5.0	-0.9	-0.2	-2.2	-1.1	-1.4	0.8	-0.9
Heart disease (siblings)	0.9	1.1	3.3	0.5	-0.5	0.1	0.3	-1.0	-1.8	-1.7
Alcohol drinker status: Previous	1.2	1.4	5.3	1.1	-0.8	0.4	2.3	-0.8	-1.4	0.2
Pack years of smoking	0.2	0.2	0.9	0.4	0.3	-0.2	0.9	-0.1	0.4	0.6
Impedance of whole body	0.4	1.9	6.4	-2.5	-0.9	-2.0	-0.7	-0.2	0.9	-0.5
Leg fat mass (left)	0.6	2.3	4.8	0.1	2.1	-0.8	-2.1	-1.2	-0.4	-2.2
Arm predicted mass (left)	0.2	1.0	3.5	1.9	1.4	-0.4	-0.7	0.8	0.4	0.0