Hub : Genes

AP4B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1530	0.0340	2.1e-14	0.199	0.156	0.184	0.195	0.196	9.1e-24	1.7e-18	8.1e-22	3.0e-23	2.4e-23
2	GTEx	Artery Tibial	0.0910	0.0383	3.4e-03	0.128	NA	0.124	NA	0.127	3.1e-10	NA	6.1e-10	NA	4.1e-10
3	GTEx	Brain Cerebellar Hemisphere	0.2860	0.0960	3.1e-03	0.225	NA	0.128	NA	0.142	1.9e-06	NA	3.7e-04	NA	1.8e-04
4	GTEx	Cells Transformed fibroblasts	0.2100	0.0470	4.1e-09	0.144	NA	0.154	NA	0.138	6.5e-11	NA	1.3e-11	NA	1.6e-10
5	GTEx	Esophagus Gastroesophageal Junction	0.1350	0.0590	4.6e-03	-0.004	NA	-0.001	NA	0.005	4.9e-01	NA	3.7e-01	NA	2.0e-01
6	GTEx	Nerve Tibial	0.2267	0.0709	1.3e-04	0.086	NA	0.082	NA	0.083	1.1e-06	NA	2.1e-06	NA	1.8e-06
7	GTEx	Spleen	0.2700	0.0970	4.8e-03	0.208	NA	0.091	NA	0.185	4.9e-06	NA	2.5e-03	NA	1.7e-05
8	GTEx	Whole Blood	0.0970	0.0340	3.2e-04	0.078	NA	0.063	NA	0.058	1.1e-07	NA	1.9e-06	NA	4.3e-06
9	METSIM	Adipose	0.0557	0.0256	4.9e-03	0.007	0.012	0.008	0.015	0.008	2.3e-02	6.2e-03	2.1e-02	2.2e-03	2.2e-02
10	ROSMAP	Brain Pre-frontal Cortex	0.0899	0.0282	5.0e-06	0.029	0.047	0.022	0.046	0.043	1.1e-04	9.1e-07	5.8e-04	1.3e-06	2.8e-06
11	YFS	Blood	0.0921	0.0220	2.1e-14	0.031	0.047	0.036	0.046	0.035	2.0e-10	5.3e-15	8.1e-12	6.8e-15	1.5e-11
12	TCGA	Breast Invasive Carcinoma	0.0579	0.0255	3.2e-09	0.057	0.048	0.051	NA	0.051	7.8e-12	3.6e-10	1.0e-10	NA	1.2e-10
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0535	0.0271	1.0e-04	0.062	0.051	0.057	NA	0.060	1.6e-07	2.0e-06	5.4e-07	NA	2.6e-07
14	TCGA	Brain Lower Grade Glioma	0.1634	0.0798	3.0e-07	0.017	0.058	0.059	NA	0.042	4.0e-03	3.3e-07	2.6e-07	NA	1.4e-05
15	TCGA	Lung Adenocarcinoma	0.0837	0.0362	5.7e-05	0.059	0.047	0.046	NA	0.050	2.0e-07	3.4e-06	4.2e-06	NA	1.6e-06
16	TCGA	Prostate Adenocarcinoma	0.0784	0.0365	8.5e-05	0.068	0.035	0.059	NA	0.064	1.3e-07	1.4e-04	8.2e-07	NA	3.2e-07
17	TCGA	Soft Tissue Sarcoma	0.0910	0.0500	1.4e-03	0.003	0.049	0.035	NA	0.024	1.9e-01	6.6e-04	3.4e-03	NA	1.4e-02
18	TCGA	Thyroid Carcinoma	0.0880	0.0450	9.2e-05	0.037	0.039	0.025	NA	0.035	1.6e-04	9.6e-05	1.6e-03	NA	2.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Bipolar Disorder (2018)	1.5	2.4	6.5	-1.6	1.1	0.4	-2.6	-1.4	1.0	1.4	1.5	-0.6	-0.2	0.4	-1.5	-2.3	-0.9	-2.3	-2.2	-1.8	-1.8
Bipolar Disorder or Schizophrenia	1.0	2.5	4.3	-1.7	1.9	1.7	-1.7	-1.9	1.7	1.9	2.1	0.0	1.0	2.0	-1.8	-1.7	-0.3	-1.7	-1.8	-0.6	-1.2
Depressed Affect (Nagel 2018)	0.3	0.6	5.6	0.1	0.1	1.0	-0.5	-0.5	0.3	-0.4	-0.2	-0.5	1.2	-2.4	0.4	-0.3	-0.5	-0.3	-0.2	0.0	0.4
Depression (Nagel 2018)	0.6	0.9	2.9	-0.4	0.3	1.4	-1.0	0.5	-0.0	0.6	0.1	0.1	1.7	-1.2	0.0	-1.7	-0.5	-1.7	-1.4	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.4	1.4	-2.0	-2.0	1.0	0.8	-1.2	-1.5	-1.9	-1.8	-2.1	-1.2	1.5	0.8	0.1	0.8	0.9	0.1	0.6
Neuroticism (Nagel 2018)	0.4	0.9	3.2	0.7	-0.5	0.3	0.4	0.7	0.0	-1.1	-0.8	-0.4	1.8	-1.7	1.2	0.8	0.2	0.8	0.8	1.0	1.3
Schizophrenia (2018)	0.6	1.3	5.4	-0.9	1.6	1.8	-0.1	-1.4	1.3	1.3	1.4	0.5	1.4	2.3	-1.0	-0.4	0.1	-0.4	-0.5	0.7	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.9	0.2	-0.6	0.1	0.1	-0.1	-0.7	-0.2	-0.4	-0.1	-0.2	-0.5	0.4	0.6	-1.0	0.6	0.5	-0.3	0.1
Worry (Nagel 2018)	1.0	2.2	6.7	1.6	0.6	0.6	1.5	0.4	0.9	-1.9	-1.0	0.5	2.6	0.2	1.6	1.6	1.7	1.6	1.6	2.0	2.0
Alzheimer’s Disease (in mother)	0.5	0.6	2.7	-1.0	-0.5	0.7	-0.6	0.4	0.0	0.8	0.5	-0.7	0.2	-1.0	-0.6	-0.8	-1.6	-0.8	-0.8	-0.6	-0.5
Alzheimer’s Disease (in father)	0.5	0.6	4.4	-0.5	-0.2	-0.4	-1.2	-2.1	-0.8	0.2	0.4	-0.4	-0.2	-0.5	-0.2	-0.6	-0.4	-0.6	-0.5	-1.0	-1.0
Alzheimer’s Disease (including proxy)	0.6	0.9	2.7	-0.7	-1.3	-0.5	-0.6	-1.2	-1.6	0.3	0.1	-1.5	-1.1	-1.6	-0.1	-0.1	-1.5	-0.1	-0.3	-1.0	-0.5
Crohns Disease (2017)	2.1	4.6	17.9	0.6	-4.2	-3.9	1.0	3.1	-4.2	-0.9	-2.2	-0.6	-2.3	-1.5	1.1	0.4	-1.5	0.4	0.4	-1.5	-0.9
Irritable Bowel Disease (IBD)	0.9	2.2	8.2	0.6	-2.6	-2.4	0.3	1.5	-2.9	-0.9	-1.6	-1.0	-1.9	-1.6	1.0	-0.1	-1.3	-0.1	0.1	-1.2	-0.7
Ulcerative Colitis (UC)	0.2	0.3	1.3	0.7	-0.2	0.0	-0.1	-0.5	-0.6	-0.9	-0.8	-1.1	-0.4	-0.9	0.7	-0.1	-0.4	-0.1	0.1	-0.3	0.0
Major Depression (MDD)	0.9	1.1	2.9	-1.0	-0.0	0.0	-1.7	-0.6	-0.2	0.7	0.8	-1.4	-0.8	-0.9	-0.8	-1.6	-1.1	-1.6	-1.5	-1.0	-1.0
Reaction Time	0.9	1.7	5.4	0.7	-2.3	-1.5	1.4	2.3	-1.7	-1.6	-1.5	-1.0	0.6	-0.5	1.1	1.0	-1.3	1.0	0.9	0.6	0.6
Verbal and Numeric Reasoning (VNR)	0.6	1.3	4.9	1.0	-1.7	-1.9	0.2	-0.0	-1.1	-1.3	-1.3	-2.2	-2.2	-0.9	1.1	0.2	-0.1	0.2	0.4	-0.3	0.1
Breast Cancer	1.9	4.7	16.3	-1.6	-2.5	-2.4	-1.1	4.0	-2.4	1.8	0.2	-0.9	-1.4	-0.8	-1.1	-3.1	-1.6	-3.1	-2.9	-2.2	-2.0
Ovarian Cancer	0.8	1.0	3.7	-0.1	1.5	1.6	0.7	1.9	1.1	0.2	0.4	1.5	1.5	0.7	0.2	0.3	0.7	0.3	0.2	1.1	1.2
Prostate Cancer	1.0	1.4	2.8	1.1	-1.1	-1.0	0.8	-1.4	-0.8	-1.4	-1.6	-0.5	-0.2	-1.6	1.7	1.4	-0.5	1.4	1.4	0.6	1.0
Age at First Birth	0.3	0.4	1.3	0.4	0.5	0.1	0.4	-1.1	0.7	-0.5	-0.1	0.6	0.5	0.6	0.1	1.1	-0.0	1.1	1.0	-0.1	0.0
Bipolar Disorder (2011)	1.3	1.3	4.7	-0.5	1.7	1.3	-0.9	-2.2	1.5	0.7	1.1	-0.7	1.8	1.5	-0.7	-0.9	0.4	-0.9	-0.8	0.4	-0.1
Body Mass Index (BMI) (2010)	1.2	1.7	4.8	-0.5	-1.9	-2.0	-0.7	-0.4	-2.2	0.2	-0.5	-0.8	-2.2	-1.5	-0.2	-0.1	-2.1	-0.1	-0.2	-1.8	-1.3
Coronary Artery Disease (CAD)	0.4	0.5	4.6	0.5	0.2	0.4	-0.4	-2.1	-0.2	-0.6	-0.3	-0.4	-0.7	-0.3	0.5	0.8	0.2	0.8	0.8	-0.1	0.2
Crohns Disease (2012)	1.7	2.8	9.4	1.2	-3.0	-3.1	1.2	1.6	-2.5	-1.6	-2.4	-0.5	-1.1	-1.2	1.6	1.2	-0.8	1.2	1.2	-1.1	-0.2
Mean Putamen Volume	0.8	0.9	2.0	-1.3	0.3	0.5	-0.8	0.9	0.4	1.2	1.2	0.8	0.4	0.8	-1.4	-1.1	-0.5	-1.1	-1.2	-1.0	-1.3
Fasting Glucose	1.3	1.5	3.4	-1.4	0.4	-0.1	-0.6	1.4	-0.4	1.8	1.2	1.5	0.5	1.2	-1.8	-1.2	-1.0	-1.2	-1.4	-1.5	-1.5
HbA1C	0.4	0.5	1.2	1.1	-0.1	-0.1	0.8	-0.9	0.3	-0.9	-0.9	0.1	-0.4	-0.2	1.0	0.8	0.4	0.8	0.9	0.6	0.7
HDL Cholesterol	0.3	0.5	1.5	-0.8	0.2	0.7	-1.0	-0.5	0.6	0.8	0.7	-0.3	0.6	0.4	-0.6	-1.2	-0.5	-1.2	-1.1	-0.3	-0.6
LDL Cholesterol	0.7	1.1	2.8	1.4	-0.9	-0.8	0.7	-1.1	-0.5	-1.3	-1.7	0.5	-0.3	-1.0	1.6	1.4	-0.1	1.4	1.4	0.5	0.8
Lupus	1.1	1.7	7.6	0.0	2.5	2.8	0.2	-2.0	1.7	-0.0	1.1	0.8	1.9	1.9	-0.7	0.5	0.1	0.5	0.4	0.5	0.1
Neuroticism (2016)	0.2	0.3	0.9	0.4	-0.7	-0.4	0.6	-0.1	-0.7	-0.3	-0.5	0.3	0.4	-0.0	0.6	0.9	0.4	0.9	0.8	0.6	0.6
Primary Biliary Cirrhosis	0.1	0.1	0.6	0.2	0.0	-0.2	0.3	0.3	-0.4	-0.3	-0.3	-0.3	0.2	-0.8	-0.0	0.4	-0.3	0.4	0.4	-0.7	-0.3
Rheumatoid Arthritis	9.7	13.4	123.2	-0.0	5.5	6.2	-2.4	-11.1	4.7	-0.1	2.2	-0.0	2.2	2.1	-1.3	0.7	-1.1	0.7	0.7	-1.4	-1.1
Schizophrenia (2014)	0.3	0.7	2.6	-1.0	0.5	0.9	-0.6	-1.1	0.1	1.1	1.0	-0.3	0.8	1.6	-0.9	-0.6	-0.9	-0.6	-0.7	-0.3	-0.7
Triglycerides	0.7	1.2	3.8	1.0	0.6	0.4	1.8	0.7	0.3	-0.6	-0.6	0.4	1.9	0.5	0.7	1.4	0.9	1.4	1.3	1.6	1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.9	0.3	-1.1	-0.7	0.1	0.1	-1.4	-1.0	-0.7	-0.0	-0.2	-0.4	-0.1	-0.0	-0.5	-0.0	0.1	-1.2	-0.7
Ulcerative Colitis	1.3	1.8	4.6	1.6	-1.4	-0.9	0.2	-1.5	-1.4	-1.9	-2.1	-2.0	-0.7	-2.1	1.9	0.5	-0.9	0.5	0.8	-0.3	0.5
Blood Eosinophil Count	0.7	5.5	14.7	-3.3	1.0	0.9	-1.9	3.8	0.4	3.5	3.0	0.9	-1.3	0.6	-3.1	-2.9	-1.3	-2.9	-3.1	-1.8	-2.1
Blood Platelet Count	0.8	9.5	24.5	3.1	3.0	3.0	3.6	1.3	3.3	-2.6	-1.6	2.8	5.0	2.4	2.6	1.6	4.9	1.6	2.0	3.9	4.0
Blood Red Count	0.4	4.1	8.0	2.8	-0.8	-1.4	2.3	-1.8	-2.0	-2.8	-2.7	-0.1	-0.5	-1.8	2.5	2.6	1.1	2.6	2.8	0.4	1.4
Blood White Count	1.0	7.6	63.5	-1.6	0.6	-0.4	0.4	8.0	1.1	2.6	1.3	2.8	0.7	2.0	-1.3	-3.8	2.1	-3.8	-3.5	0.6	-0.2
Heel T-Score	0.6	4.5	13.0	-2.3	2.7	3.5	-0.8	-1.6	2.8	2.3	3.6	0.6	-0.4	3.6	-2.3	-0.9	1.1	-0.9	-1.3	2.0	-0.3
BMI	0.2	1.3	2.9	-1.5	-0.8	-0.2	-1.7	-1.7	-0.5	1.7	0.9	-0.1	-0.2	-0.2	-0.9	-1.2	-1.5	-1.2	-1.2	-0.9	-1.5
Height	0.0	0.7	7.3	0.0	0.1	0.7	-0.5	2.7	0.4	0.3	0.1	0.1	-0.3	-0.9	-0.0	-0.8	-0.2	-0.8	-0.7	0.7	0.3
Waist Hip Ratio (WHR)	0.4	1.9	5.3	-0.9	-2.1	-1.9	-0.9	-0.2	-2.3	0.2	-0.1	-1.8	-0.4	-0.1	-0.8	-0.7	-2.2	-0.7	-0.7	-2.0	-2.0
Systolic Blood Pressure	1.1	5.5	11.3	3.1	-0.8	-1.8	3.3	-1.0	-1.4	-3.3	-3.1	1.8	1.2	0.1	2.7	3.3	1.5	3.3	3.4	0.8	1.9
Smoking Status	2.3	5.6	13.5	-2.9	0.6	0.4	-2.4	3.0	1.1	3.0	2.2	-1.2	-1.3	0.3	-2.4	-3.7	-2.0	-3.7	-3.7	-1.9	-1.9
Allergy or Eczema	1.4	3.7	8.9	2.4	-1.6	-1.8	3.0	2.5	-1.2	-2.2	-2.3	0.9	-0.9	0.7	1.9	1.9	2.0	1.9	2.0	2.0	2.0
Cardiovascular Disease	0.6	2.0	10.2	1.2	0.6	0.6	1.8	-1.0	1.1	-1.0	-0.9	1.7	3.2	0.2	1.1	1.8	1.1	1.8	1.7	1.3	1.3
Hypothyroidism (self reported)	11.3	26.0	163.8	-1.6	8.8	9.2	-4.4	-12.8	6.5	1.6	5.3	-1.0	4.0	3.0	-3.6	-0.7	-1.0	-0.7	-0.7	-1.4	-1.9
Respiratory disease	0.2	0.5	1.3	1.1	0.6	0.9	0.4	-1.0	0.3	-1.1	-0.8	-0.2	0.8	-0.4	0.9	0.1	0.5	0.1	0.4	0.5	1.0
Type 2 Diabetes (T2D) (2018)	1.3	2.5	7.0	2.0	0.1	0.7	1.5	-1.9	0.8	-1.7	-1.7	0.4	2.6	-0.7	1.6	2.2	0.2	2.2	2.3	1.0	1.4
Lung FEV1/FVC ratio	1.1	5.8	13.5	-3.1	0.7	1.3	-2.1	1.3	0.4	3.3	2.8	-0.2	-0.9	2.2	-3.0	-3.6	-1.2	-3.6	-3.7	-1.8	-2.7
Lung FVC	0.5	2.8	17.2	2.0	0.4	0.0	1.0	-4.1	0.4	-2.1	-1.6	-0.8	0.4	-0.7	1.8	2.1	1.4	2.1	2.2	0.1	1.2
Neuroticism	0.8	1.9	6.3	1.2	-1.6	-1.2	0.6	-0.0	-0.7	-2.0	-1.8	-0.4	0.8	-2.5	1.9	1.5	-0.3	1.5	1.5	0.6	1.4
Chronotype (morning person)	1.2	2.8	9.9	1.6	-0.1	-0.6	1.8	-0.6	-0.3	-1.6	-1.6	2.2	1.5	-1.2	1.3	3.1	0.4	3.1	2.9	0.1	0.7
Hair Pigment	0.1	1.5	3.2	1.4	0.9	1.1	1.3	-0.3	1.4	-1.1	-0.9	1.8	1.5	-0.2	1.2	1.3	1.1	1.3	1.4	1.2	1.4
Tanning	0.3	4.1	10.5	-2.6	-0.6	-0.6	-1.9	3.2	-0.7	2.3	2.0	-1.0	-1.7	-0.6	-2.6	-2.3	-2.2	-2.3	-2.5	-1.9	-2.5
Hand grip strength (left)	1.5	3.9	8.1	-2.5	-0.9	-1.3	-2.4	1.0	-0.9	2.4	1.4	-1.8	-2.0	-0.7	-2.0	-2.1	-2.9	-2.1	-2.2	-2.6	-2.4
Number of treatments/medications taken	1.2	2.2	14.4	0.4	1.6	2.4	-0.8	-2.2	2.6	0.0	0.1	1.5	3.8	-0.3	0.2	-0.3	-0.0	-0.3	-0.1	0.6	0.4
Average weekly spirits intake	0.5	0.6	3.9	-0.5	-0.9	0.4	-0.4	2.0	-0.4	0.2	-0.1	-0.7	0.7	-0.7	-0.2	-0.6	-1.6	-0.6	-0.6	-0.1	0.0
Sensitivity / hurt feelings	0.4	0.7	4.8	-0.3	-1.2	-0.4	-0.6	1.6	-1.2	-0.0	-0.2	-0.2	-0.1	-2.2	0.2	-0.6	-0.2	-0.6	-0.5	0.0	-0.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	6.1	0.2	1.2	1.7	-0.0	1.0	0.9	0.0	0.1	1.1	2.5	-0.7	0.1	-0.4	0.5	-0.4	-0.3	0.7	0.6
Hearing difficulty/problems: Yes	0.5	0.8	2.4	-1.0	-0.5	-0.4	-1.0	0.5	-0.7	0.8	0.6	-1.3	-0.9	-1.5	-0.8	-0.9	-0.6	-0.9	-0.9	-1.0	-1.0
Relative age of first facial hair	0.4	0.8	3.9	0.6	-0.2	-0.1	1.3	2.0	-0.2	-0.4	-0.6	0.4	0.4	0.3	0.7	0.8	1.0	0.8	0.7	1.3	1.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	7.1	-0.7	-0.1	-0.2	-2.0	-2.7	-0.6	0.5	0.6	-1.1	-0.3	-2.3	-1.1	-1.3	-2.0	-1.3	-1.1	-2.2	-2.1
Ever used hormone-replacement therapy (HRT)	0.4	0.4	0.9	0.9	-0.4	-0.4	0.7	0.9	-0.9	-0.8	-0.9	0.3	-1.0	-0.5	0.8	0.3	0.7	0.3	0.5	0.2	0.7
Ever had hysterectomy (womb removed)	0.8	0.9	4.8	0.2	-1.0	-1.2	-0.3	0.5	-1.4	0.2	-0.6	-1.5	-1.7	-2.2	0.3	-0.3	-0.2	-0.3	-0.2	-0.4	-0.2
Systolic blood pressure, automated reading	0.3	1.0	3.1	0.9	-0.7	-1.6	0.8	0.0	-1.6	-1.1	-1.3	1.8	-0.9	-0.4	0.7	0.7	0.1	0.7	0.8	-1.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.7	-0.4	0.8	1.3	-0.8	-1.3	1.6	0.3	0.7	-0.7	0.4	-0.1	-0.2	0.1	-0.1	0.1	0.0	0.7	0.2
Angina	0.6	0.8	3.1	-1.0	0.0	0.5	-1.3	-1.8	-0.1	0.9	0.9	-1.6	-0.0	-0.4	-0.9	-0.3	-1.2	-0.3	-0.4	-0.8	-1.0
Medication for hormone replacement therapy	0.4	0.4	2.2	-0.1	0.8	0.7	0.4	1.4	0.3	0.1	0.6	0.1	1.5	0.9	-0.5	-0.2	0.9	-0.2	-0.2	0.4	-0.1
Vitamin and mineral supplements	0.5	0.7	2.1	-0.0	1.2	0.7	0.4	-0.6	1.4	0.0	0.2	0.6	-0.1	-1.1	0.4	1.3	0.2	1.3	1.1	1.1	1.1
Supplements: Zinc	0.3	0.3	1.5	0.2	0.6	0.3	0.2	0.6	0.8	-0.0	-0.1	0.1	1.2	1.1	-0.2	-0.6	-0.1	-0.6	-0.5	-0.6	-0.1
Medication: Co-codamol	0.9	1.0	2.6	-1.2	-0.2	-0.1	-1.5	0.4	-0.5	1.3	1.0	-0.0	-0.5	0.1	-1.0	-1.6	-0.3	-1.6	-1.5	-0.6	-1.3
Medication: Metformin	0.8	1.2	4.8	0.8	0.9	1.8	0.3	-1.7	1.5	-0.5	-0.2	0.9	2.2	0.1	0.7	0.7	0.7	0.7	0.8	1.3	0.9
Diabetes (father)	0.2	0.3	2.4	0.7	-0.0	-0.0	0.2	-0.2	0.5	-0.4	-0.5	-0.7	1.6	-0.3	0.4	0.1	0.6	0.1	0.3	0.4	0.3
Diabetes (mother)	1.3	1.7	5.3	0.8	-2.3	-2.1	0.5	1.0	-2.3	-1.2	-1.7	-0.6	0.4	-2.1	1.3	0.8	-0.7	0.8	0.8	0.0	0.5
Severe depression (siblings)	0.9	1.0	2.2	-0.7	-1.0	-1.0	-1.5	-1.1	-0.9	0.2	0.1	-0.9	-1.2	-0.3	-0.4	-1.2	-1.5	-1.2	-1.0	-1.4	-1.1
Pack years adult smoking proportion	0.1	0.2	1.7	0.2	0.5	0.3	0.2	-0.2	0.5	0.2	0.0	1.3	0.2	-0.4	0.0	-0.4	0.9	-0.4	-0.3	0.3	0.0
Impedance of leg (right)	0.2	1.0	6.9	0.1	0.5	0.6	0.7	2.6	0.7	0.1	0.1	1.1	1.9	0.8	-0.2	-0.9	1.3	-0.9	-0.8	0.7	0.5
Leg fat-free mass (left)	0.2	1.3	3.3	-1.6	0.5	0.7	-1.5	-0.4	0.2	1.8	1.7	-0.8	-1.4	0.8	-1.3	-1.1	-1.1	-1.1	-1.2	-0.5	-1.1
Trunk fat percentage	0.6	2.4	5.9	-1.9	1.3	1.6	-1.4	0.3	1.3	2.4	2.1	1.1	0.9	1.1	-1.4	-2.2	-0.2	-2.2	-2.2	0.9	-0.3
Hand grip strength (right)	0.4	1.0	2.3	-1.1	-0.2	-0.2	-1.5	-0.3	-0.4	1.3	0.8	-1.1	-0.8	-0.6	-0.9	-1.0	-1.5	-1.0	-1.1	-1.2	-1.2
Townsend deprivation index at recruitment	1.7	2.3	6.4	1.9	-0.7	-0.6	2.0	0.4	-0.4	-1.5	-2.0	0.1	0.4	-0.8	2.3	1.5	1.1	1.5	1.6	2.5	2.5
Current tobacco smoking	2.5	4.1	11.2	-2.5	0.5	-0.3	-2.0	3.3	0.8	2.9	1.9	-0.2	-0.0	0.4	-2.1	-3.1	-1.4	-3.1	-3.1	-1.3	-1.7
Average weekly fortified wine intake	0.5	0.6	6.7	-0.4	-0.8	-0.8	0.1	2.6	-0.7	0.2	0.1	0.3	-0.8	0.2	-0.5	-0.3	-0.0	-0.3	-0.4	-0.3	-0.5
Maternal smoking around birth	0.9	1.3	5.3	0.0	-2.3	-1.7	-0.4	0.9	-2.2	0.2	-1.0	-0.8	-0.7	-1.9	0.7	-0.5	-1.5	-0.5	-0.4	-0.2	-0.3
Fed-up feelings	0.5	0.9	6.2	0.9	-0.4	0.7	0.6	0.8	-0.3	-0.7	-1.0	1.1	2.5	-1.2	1.0	0.5	-0.5	0.5	0.6	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	8.4	1.0	-1.0	-0.4	0.1	0.7	-1.2	-0.7	-1.4	-0.6	1.9	-2.9	1.4	0.3	-0.1	0.3	0.5	0.7	0.9
Relative age voice broke	0.2	0.3	1.6	-0.2	-0.4	-0.6	0.3	1.3	-0.4	0.1	-0.1	0.2	-0.2	-0.4	0.2	0.6	-0.9	0.6	0.4	0.6	0.7
Taking other prescription medications	1.7	2.7	13.8	-0.1	2.6	3.7	-0.8	-3.1	2.4	0.5	1.2	1.3	2.7	-0.4	-0.7	0.0	0.4	0.0	0.0	0.4	-0.1
Age when periods started (menarche)	0.5	1.3	9.1	0.5	-0.8	-0.8	1.1	3.0	-0.1	-0.0	-0.6	2.7	0.1	-0.7	0.4	0.0	1.4	0.0	0.1	0.4	0.5
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	6.0	2.3	-1.6	-0.9	1.8	-0.6	-1.1	-2.3	-2.3	-0.7	1.0	-1.7	2.5	2.0	1.5	2.0	2.2	1.4	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.7	-0.9	0.9	1.2	-0.3	0.7	1.2	1.1	1.4	0.8	0.9	1.6	-0.9	-1.0	0.6	-1.0	-1.1	1.1	0.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.1	-1.0	-0.5	-0.6	-1.5	-0.5	-0.8	0.8	0.7	-0.2	-0.1	-0.6	-1.3	-0.8	-1.5	-0.8	-0.8	-1.7	-2.0
Qualifications: CSEs or equivalent	1.0	1.3	3.7	1.3	-0.7	-0.8	0.3	-1.5	-0.2	-1.9	-1.1	-0.8	-0.9	-1.9	1.3	1.3	0.4	1.3	1.3	0.7	1.2
Serious illness, injury or assault to yourself	1.4	1.7	7.5	0.5	-1.3	1.1	-0.1	-1.9	0.4	-0.7	-1.2	0.1	2.7	-2.1	1.3	1.3	-1.7	1.3	1.2	0.7	0.8
High blood pressure	1.3	3.6	11.4	1.8	1.3	1.2	2.5	1.2	1.7	-1.4	-1.1	3.1	3.4	0.9	1.3	1.6	2.3	1.6	1.7	2.0	2.0
Hayfever, allergic rhinitis or eczema	1.1	2.3	7.0	1.6	-0.7	-1.1	2.6	2.6	-0.7	-1.5	-1.4	0.9	-1.0	1.3	1.1	1.2	2.0	1.2	1.3	1.6	1.5
Multivitamins +/- minerals	0.6	0.7	2.7	-0.5	0.4	1.2	-0.2	0.9	-0.3	0.5	0.7	-0.3	1.0	1.6	-0.9	-1.2	0.0	-1.2	-1.1	-0.8	-0.9
Stomach or abdominal pain in last month	0.3	0.4	2.6	-0.2	-0.7	-0.6	-0.5	-1.6	-0.1	0.3	-0.2	-0.3	0.5	-0.4	0.2	0.0	-1.4	0.0	-0.0	0.0	0.1
Supplements: Glucosamine	0.6	0.8	5.0	0.6	-1.0	-1.2	0.5	2.2	-1.0	-0.8	-1.0	1.7	0.2	-0.1	0.6	-0.5	-0.3	-0.5	-0.3	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.9	0.7	-0.6	-0.9	0.3	-0.1	-0.0	-1.0	-0.8	0.2	-0.1	-1.7	0.6	0.7	-0.0	0.7	0.8	0.1	0.3
Medication: Atenolol	0.1	0.2	1.0	-0.1	0.4	0.5	-0.3	0.3	0.0	0.1	0.1	0.5	0.6	-1.0	-0.2	-0.3	-0.1	-0.3	-0.3	-0.5	-0.4
Medication: Levothyroxine sodium	7.8	13.2	73.1	-1.3	6.6	7.2	-3.0	-8.6	4.9	1.4	4.0	-1.1	1.9	1.6	-2.5	-0.4	-0.0	-0.4	-0.5	-0.3	-0.9
Sitting height	0.0	0.3	1.3	-0.0	-0.4	-0.1	-0.0	0.1	-0.0	0.0	0.0	-0.4	-0.4	-0.4	-0.2	1.0	-1.1	1.0	0.8	-0.2	-0.4
Chronic bronchitis/emphysema (father)	1.4	1.6	7.1	-0.8	-1.7	-2.7	-1.1	1.2	-0.8	0.5	-0.3	-0.9	-0.6	-2.2	-0.1	-0.8	-2.3	-0.8	-0.8	-0.9	-0.7
High blood pressure (mother)	0.5	0.7	2.0	-0.6	-0.5	-0.0	-0.3	0.7	-1.4	0.7	0.3	0.2	0.8	-0.2	-0.9	-0.6	-1.3	-0.6	-0.7	-1.3	-1.3
Body mass index (BMI)	0.5	2.0	5.6	-2.0	1.2	1.0	-1.8	-0.6	0.9	2.4	2.1	0.4	-0.3	1.0	-1.5	-1.7	-0.8	-1.7	-1.9	-0.1	-0.9
Impedance of leg (left)	0.2	0.9	5.9	0.4	0.1	0.4	0.9	2.4	0.4	-0.2	-0.3	0.8	2.2	0.2	0.3	-0.5	1.1	-0.5	-0.4	1.1	0.9
Leg predicted mass (left)	0.2	1.2	3.2	-1.5	0.6	0.7	-1.4	-0.5	0.2	1.8	1.6	-0.8	-1.4	0.8	-1.3	-1.0	-1.1	-1.0	-1.1	-0.5	-1.1
Trunk fat mass	0.7	2.9	7.9	-2.3	1.2	1.5	-1.7	0.6	1.3	2.8	2.4	0.9	0.6	1.2	-1.7	-2.4	-0.6	-2.4	-2.4	0.5	-0.7
Waist circumference	0.9	3.4	8.1	-2.7	0.3	0.6	-2.3	0.1	0.3	2.9	2.4	0.0	-0.2	1.3	-2.2	-2.5	-1.7	-2.5	-2.7	-0.8	-1.8
Number of incorrect matches in round	1.0	1.6	7.9	-1.5	0.2	0.6	-2.1	-2.8	-0.7	0.7	1.3	-1.5	-1.0	-0.6	-1.0	-0.8	-1.6	-0.8	-1.0	-1.0	-1.1
Past tobacco smoking	1.3	2.4	8.7	1.7	0.0	0.1	1.6	-3.0	-0.3	-1.7	-1.2	0.8	1.3	0.1	1.4	2.5	1.0	2.5	2.4	1.1	0.9
Alcohol usually taken with meals	1.5	2.4	6.6	1.1	2.2	1.9	1.1	-1.7	2.3	-0.5	0.2	0.8	2.2	1.9	0.2	1.1	2.6	1.1	1.1	1.7	1.3
Nervous feelings	0.6	1.1	6.2	0.6	1.4	1.0	0.4	0.3	1.4	-1.0	-0.1	0.4	2.5	0.2	0.5	0.9	1.1	0.9	0.8	0.9	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	6.1	-0.0	-0.2	0.5	-0.9	-0.9	-0.0	-0.1	-0.2	-0.3	2.5	-1.9	0.2	-0.4	-0.9	-0.4	-0.3	-0.2	-0.1
Hearing difficulty/problems with background noise	1.1	1.7	4.0	-0.9	-1.4	-1.4	-1.1	2.0	-0.9	0.7	0.0	-1.1	-0.7	-1.6	-0.7	-1.7	-1.5	-1.7	-1.6	-1.4	-1.4
Hair/balding pattern: Pattern 2	0.2	0.2	1.3	-0.2	-1.2	-0.2	0.0	0.9	-0.6	0.3	-0.3	-0.1	0.1	-0.2	0.2	-0.4	-0.8	-0.4	-0.3	0.2	-0.1
Had menopause	1.7	2.1	4.7	-1.7	1.2	1.1	-1.6	0.9	0.7	1.5	1.9	0.9	-1.0	1.3	-1.7	-2.2	-0.2	-2.2	-2.1	-0.9	-1.3
Had other major operations	0.9	1.1	4.0	1.5	0.3	-0.2	1.5	0.3	-0.1	-1.7	-1.0	-0.1	1.0	0.4	1.1	1.1	2.0	1.1	1.2	0.8	0.8
Forced vital capacity (FVC)	0.8	3.2	6.1	1.9	-1.9	-1.9	0.3	-2.4	-1.4	-2.2	-2.5	-2.4	-1.1	-2.5	2.2	1.7	-0.5	1.7	1.9	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.0	-0.2	1.4	2.0	0.2	0.3	1.8	0.2	1.0	0.7	1.5	1.7	-0.3	-0.2	1.1	-0.2	-0.2	1.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.2	-1.1	-0.1	0.3	-1.6	-0.5	-0.2	1.1	0.8	-0.1	1.3	-0.3	-1.0	-0.8	-1.8	-0.8	-0.9	-1.1	-1.4
Qualifications: None of the above	0.4	0.9	7.9	0.3	-1.1	-0.7	0.3	0.7	-0.7	-0.0	-1.0	1.1	0.5	-2.8	1.1	0.2	-0.9	0.2	0.3	0.6	0.9
Financial difficulties in last 2 years	0.8	1.1	6.0	0.3	-2.1	-1.5	-0.1	-0.2	-2.5	-0.2	-1.3	-0.2	-0.5	-1.4	0.7	-0.3	-1.2	-0.3	-0.1	-1.0	-0.4
Mouth/teeth dental problems	0.8	1.2	3.5	-1.0	1.8	1.2	0.2	1.2	1.1	1.1	1.9	0.5	0.4	1.8	-1.6	-0.4	1.1	-0.4	-0.6	0.4	-0.4
Heart attack	0.7	1.0	6.1	-0.1	1.2	1.5	-0.3	-2.5	1.9	0.1	0.4	-0.6	1.3	0.2	-0.0	0.2	-0.2	0.2	0.2	0.8	0.7
Allergy	1.2	2.8	7.1	-2.1	-0.3	0.1	-2.6	-1.7	-0.4	1.8	1.4	-1.2	-0.1	-0.8	-1.5	-1.5	-2.7	-1.5	-1.6	-2.3	-2.3
Pain all over the body in last month	2.4	2.5	6.1	2.4	0.7	0.3	1.8	-0.4	1.5	-2.0	-1.9	1.1	2.5	-0.4	2.0	1.2	1.7	1.2	1.5	1.7	1.9
Diabetes (self-reported)	1.7	2.6	8.8	1.8	1.1	1.9	1.2	-2.7	1.6	-1.2	-0.9	0.6	3.0	0.6	1.1	1.8	1.3	1.8	1.9	1.4	1.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	4.8	0.3	-0.7	-1.4	1.0	2.2	-1.3	-0.5	-0.3	-0.6	-1.0	0.6	-0.1	0.3	0.7	0.3	0.3	0.4	0.3
Medication: Ramipril	2.9	3.7	8.6	2.3	0.3	0.5	2.1	-0.3	1.0	-2.1	-1.8	0.6	2.9	1.0	2.1	2.2	1.8	2.2	2.3	2.8	2.7
Medication: Simvastatin	1.2	1.8	3.8	1.4	-0.5	0.1	1.4	0.2	0.4	-1.3	-1.4	0.8	1.9	-1.0	1.5	1.7	1.6	1.7	1.7	1.6	1.7
Fluid intelligence score	0.5	1.0	3.7	1.2	-0.9	-1.1	0.2	-0.7	-0.6	-1.4	-1.4	-1.9	-1.1	-1.6	1.3	0.5	-0.3	0.5	0.7	-0.2	0.4
Illnesses of siblings	1.3	1.8	5.9	-1.2	-1.3	-1.0	-1.4	-1.5	-1.3	1.0	0.8	-2.1	-2.4	-0.4	-1.0	-0.7	-1.5	-0.7	-0.8	-1.8	-1.8
Neuroticism score	0.4	0.8	5.2	0.7	-0.2	0.2	0.3	0.5	0.1	-1.2	-0.7	0.2	2.3	-1.3	0.9	0.8	0.5	0.8	0.8	0.8	1.0
Weight	0.4	2.0	6.0	-2.1	0.7	0.9	-1.9	0.2	0.6	2.5	2.1	0.0	-0.4	0.8	-1.6	-1.8	-1.1	-1.8	-1.9	-0.2	-1.1
Impedance of arm (right)	0.0	0.2	0.5	0.6	-0.4	-0.2	0.4	0.4	-0.3	-0.7	-0.6	-0.6	0.5	-0.5	0.5	-0.3	0.6	-0.3	-0.1	0.5	0.7
Arm fat percentage (right)	0.7	2.6	6.8	-2.3	1.1	1.1	-2.0	-0.2	1.1	2.6	2.4	0.1	0.1	1.2	-1.7	-2.3	-0.8	-2.3	-2.4	0.1	-0.8
Trunk fat-free mass	0.3	1.7	4.2	-1.8	0.4	0.4	-1.5	1.0	0.4	2.0	1.7	-0.3	-1.2	0.7	-1.7	-1.2	-1.2	-1.2	-1.4	-1.1	-1.7
Hip circumference	0.8	3.5	9.5	-2.7	1.3	1.6	-2.1	0.5	1.5	3.1	2.8	0.0	-0.5	1.4	-2.0	-2.6	-0.8	-2.6	-2.7	0.2	-0.9
Time employed in main current job	0.4	0.5	1.5	0.3	-0.8	-1.1	-0.5	0.5	-0.0	-0.3	-0.6	-1.2	-0.7	-1.2	0.5	-0.9	0.2	-0.9	-0.6	-0.3	-0.1
Alcohol intake versus 10 years previously	0.5	0.7	3.3	-0.9	0.0	0.1	-0.9	-0.6	-0.6	1.1	0.7	-0.5	-0.1	0.3	-0.9	-0.7	-1.8	-0.7	-0.7	-1.2	-1.2
Father’s age at death	0.4	0.5	4.1	-0.5	-0.3	-0.3	0.3	2.0	0.1	0.6	0.2	-0.1	-1.9	-0.0	-0.5	-0.4	-0.0	-0.4	-0.5	-0.3	-0.2
Worrier / anxious feelings	0.5	0.9	2.8	1.0	0.3	0.6	0.9	-0.2	0.5	-1.2	-0.4	1.0	1.7	1.3	0.9	0.5	1.7	0.5	0.7	1.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	9.6	1.9	-0.1	0.7	0.7	-1.2	0.5	-1.6	-1.9	0.5	3.1	-3.1	2.2	2.0	-0.2	2.0	2.0	1.1	1.6
Falls in the last year	0.2	0.3	3.0	0.1	0.2	-0.1	-0.3	0.1	0.8	-0.3	-0.2	-0.1	0.8	-1.7	0.5	-0.4	0.2	-0.4	-0.2	0.2	0.4
Hair/balding pattern: Pattern 3	0.8	1.2	4.0	-0.1	-1.6	-1.7	0.0	-0.5	-1.7	-0.3	-0.7	-0.6	-2.0	-0.5	0.1	0.8	-1.7	0.8	0.6	-1.4	-0.7
Number of live births	1.0	1.4	4.5	1.2	-0.1	-0.4	1.7	1.5	0.0	-0.9	-0.8	0.4	-0.1	0.2	1.2	1.1	2.1	1.1	1.2	2.0	2.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	5.4	1.5	-1.7	-1.4	0.3	-2.3	-1.3	-1.7	-1.9	-2.3	-1.0	-1.5	1.9	1.3	-0.3	1.3	1.4	-0.2	0.6
Pulse rate	0.1	0.1	0.5	0.0	-0.3	-0.5	0.2	0.5	-0.2	0.1	-0.1	0.7	-0.0	-0.5	-0.0	0.3	-0.4	0.3	0.2	-0.1	-0.4
Happiness	0.6	0.7	2.0	-1.2	1.1	0.2	-1.2	0.1	1.4	1.0	1.4	-0.7	0.1	-0.4	-0.9	-0.7	0.2	-0.7	-0.8	-0.1	-0.3
Noisy workplace	0.6	0.7	2.8	-0.3	-1.5	-1.7	-0.2	-0.8	-1.6	0.1	-0.5	-0.0	-0.0	-1.6	0.2	0.4	-0.9	0.4	0.3	-0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	4.6	-0.4	0.7	0.2	-0.4	-0.3	0.5	0.6	0.7	-1.4	-1.0	2.1	-0.9	-0.5	0.3	-0.5	-0.5	-0.6	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	0.4	-0.9	-0.4	0.2	1.0	-0.6	-0.6	-0.6	0.3	0.5	-0.8	0.5	0.7	-0.1	0.7	0.7	0.5	0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	3.5	-0.8	-0.6	-0.8	-1.6	-0.5	-0.7	0.7	0.1	-1.4	-1.9	-1.3	-0.6	-1.1	-1.7	-1.1	-1.1	-1.6	-1.1
Asthma	0.2	0.4	1.6	0.9	1.1	1.0	0.7	-1.3	0.4	-0.7	-0.2	0.4	0.3	0.4	0.4	0.5	0.5	0.5	0.6	0.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	-0.5	0.2	0.1	-0.9	-0.5	1.1	0.9	0.3	0.3	0.4	0.3	-0.3	-0.6	-1.1	-0.6	-0.6	-0.6	-0.3
Medication: Cholesterol lowering	0.9	1.4	7.3	0.4	1.6	1.4	0.6	-1.7	2.2	0.0	-0.0	1.0	2.7	0.1	0.2	0.8	0.9	0.8	0.8	0.6	0.7
Depression (self-reported)	2.6	3.1	7.1	-2.0	1.1	0.5	-2.2	0.3	0.6	2.3	2.0	0.1	0.4	0.4	-2.2	-2.7	-0.8	-2.7	-2.6	-2.0	-2.3
Medication: Lansoprazole	0.3	0.3	1.2	0.4	0.4	0.6	0.3	-0.3	0.4	-0.5	-0.2	0.7	1.1	-0.2	0.4	0.8	-0.1	0.8	0.8	0.6	0.7
Prospective memory result	0.6	0.7	2.4	-1.3	0.7	0.6	-0.6	0.2	-0.0	1.6	1.4	-0.4	0.0	0.3	-1.2	-0.9	-0.2	-0.9	-1.0	-0.3	-0.7
Lung cancer (father)	0.9	1.0	6.6	0.3	-1.8	-1.1	0.2	1.7	-2.6	-0.2	-1.0	0.4	-0.4	-1.3	0.5	0.0	-0.9	0.0	0.1	-0.5	-0.4
Illnesses of mother	3.8	4.7	10.7	3.1	-0.2	-0.8	2.1	-2.1	0.2	-3.0	-2.6	-0.2	-0.1	-0.3	3.3	2.5	2.3	2.5	2.8	2.2	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.0	1.4	-0.9	-0.9	0.4	-2.2	-0.2	-1.3	-1.5	-2.2	-0.5	-1.1	1.5	0.9	0.3	0.9	1.1	-0.1	0.6
Pulse wave Arterial Stiffness index	0.9	1.1	5.2	0.4	-1.6	-1.6	0.6	2.3	-1.6	-0.5	-1.1	0.5	-1.7	-0.5	0.6	-0.5	0.1	-0.5	-0.3	-0.5	-0.2
Impedance of arm (left)	0.2	0.9	2.2	1.4	-0.4	0.1	1.3	0.1	0.0	-1.4	-1.2	-0.1	0.9	-0.3	1.3	0.5	1.3	0.5	0.8	1.4	1.5
Arm fat mass (right)	0.6	2.3	6.7	-2.3	0.8	0.8	-1.9	0.1	0.8	2.6	2.3	0.1	-0.2	1.0	-1.7	-2.0	-0.9	-2.0	-2.1	-0.1	-1.0
Trunk predicted mass	0.3	1.5	3.9	-1.7	0.4	0.4	-1.4	1.0	0.4	2.0	1.7	-0.2	-1.3	0.6	-1.7	-1.2	-1.2	-1.2	-1.3	-1.1	-1.6
Standing height	0.1	0.5	3.8	-0.5	-0.8	-0.4	-0.5	1.9	-0.5	0.7	0.4	-0.7	-0.8	-0.4	-0.6	-0.6	-0.7	-0.6	-0.6	-0.3	-0.7
Length of working week for main job	0.5	0.6	3.2	0.4	-0.5	-0.3	0.6	1.5	0.9	-0.4	-0.8	-0.9	-0.2	-1.8	0.8	0.4	-0.2	0.4	0.4	0.4	1.0
Exposure to tobacco smoke at home	0.5	0.5	1.8	0.1	-1.3	-0.9	-0.5	0.7	-0.4	0.1	-0.5	-0.8	-1.3	0.4	0.2	-1.0	-0.7	-1.0	-0.8	-0.2	-0.3
Breastfed as a baby	0.5	0.7	3.6	-0.5	0.7	0.7	-0.7	1.1	0.7	0.5	0.8	1.0	-1.9	1.1	-0.5	-0.7	0.5	-0.7	-0.7	0.2	0.0
Tense / ‘highly strung’	2.4	4.0	16.1	2.0	1.4	1.1	1.9	-0.3	1.4	-1.8	-1.1	1.8	4.0	1.0	1.7	2.1	2.5	2.1	2.1	2.6	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.4	-1.2	-0.4	-0.6	-1.9	0.1	-0.9	0.8	0.9	-1.6	-0.2	0.1	-1.1	-1.6	-0.6	-1.6	-1.5	-0.9	-1.2
Hair/balding pattern: Pattern 4	0.2	0.5	2.6	0.3	0.7	0.9	0.5	-0.3	0.6	-0.3	0.1	1.6	1.4	-0.4	0.1	0.4	1.0	0.4	0.4	0.8	0.6
Birth weight of first child	0.4	0.8	5.7	-0.2	-1.0	-1.5	0.0	2.4	-0.1	0.2	-0.0	-0.3	-1.3	-0.5	-0.3	-0.7	0.0	-0.7	-0.7	-0.6	-0.7
Peak expiratory flow (PEF)	0.3	0.7	7.1	-0.2	-0.2	-0.6	-0.7	-0.9	-0.6	0.4	0.3	-2.7	-1.5	0.1	-0.2	-0.6	0.5	-0.6	-0.5	-0.5	-0.4
Pulse wave reflection index	0.5	0.6	3.7	-0.3	-1.0	-1.0	0.1	1.9	-1.1	0.0	-0.2	0.0	-1.2	-0.2	-0.1	-0.7	-0.3	-0.7	-0.6	-0.6	-0.4
Ever highly irritable/argumentative for 2 days	2.3	2.8	7.8	1.9	0.3	0.5	1.8	-0.1	0.4	-1.8	-1.6	1.2	2.8	-0.6	1.8	2.4	1.1	2.4	2.3	1.6	2.0
Loud music exposure frequency	0.2	0.2	1.6	0.1	-0.4	-0.1	-0.1	-0.2	0.1	0.1	-0.5	0.5	1.0	-0.2	0.0	0.2	-1.2	0.2	0.2	-0.8	-0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.3	-0.6	-0.3	-1.0	-0.7	-0.1	0.2	0.1	0.5	-1.3	-1.5	1.1	-0.6	-0.3	0.2	-0.3	-0.4	-0.4	-0.7
Mouth/teeth dental problems: Bleeding gums	4.9	6.3	11.6	3.3	0.2	0.9	2.6	-1.2	1.0	-2.9	-2.8	1.6	3.4	0.4	3.4	2.8	2.2	2.8	3.0	3.1	3.4
Blood clot in the leg (DVT)	1.5	1.9	6.1	1.1	1.4	1.3	1.4	1.0	1.0	-0.9	-0.3	1.7	2.5	0.3	0.8	1.1	2.1	1.1	1.1	1.9	1.7
Medication: Paracetamol	1.0	1.7	5.8	-1.2	0.8	0.8	-1.8	-1.0	1.0	1.5	1.1	-0.2	1.3	0.3	-0.8	-2.4	-0.8	-2.4	-2.2	-0.0	-0.2
Headache pain in last month	0.2	0.4	3.1	-0.1	-0.3	0.6	-0.5	-1.8	0.1	0.3	-0.2	-0.6	1.0	-0.0	-0.1	0.1	-1.2	0.1	0.1	-0.6	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	11.0	-0.3	-1.1	-1.5	-0.6	1.1	-2.1	-0.1	0.1	-0.8	-3.3	0.2	-0.1	-1.3	0.1	-1.3	-1.1	-0.5	-0.5
Glaucoma (self-reported)	0.7	0.8	2.4	0.9	-1.5	-1.3	0.1	0.8	-1.3	-0.8	-1.6	0.3	1.0	-1.3	1.1	-0.1	-0.0	-0.1	0.2	-0.5	0.0
Gout (self-reported)	0.2	0.3	1.3	-0.4	-0.6	-0.4	-0.1	0.6	-0.9	0.3	0.2	-0.5	-1.1	-0.7	-0.5	-0.3	-0.6	-0.3	-0.3	-0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	9.9	19.4	114.5	-1.3	7.9	8.6	-3.3	-10.7	5.6	1.3	4.7	-0.7	3.3	2.9	-3.0	-0.1	-0.2	-0.1	-0.2	-0.4	-1.1
Medication: Amlodipine	0.5	0.7	3.6	1.0	-0.2	-0.7	-0.0	-1.9	0.2	-0.9	-1.0	-1.0	0.7	-1.1	0.8	0.9	-0.2	0.9	0.9	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	1.3	1.7	2.9	1.3	-1.2	-1.7	0.9	-1.5	-1.4	-1.7	-1.6	-0.9	-1.4	-1.7	1.1	1.6	-0.2	1.6	1.6	-0.6	0.2
Birth weight	0.5	1.1	8.8	0.6	-1.0	-1.4	0.4	3.0	-1.3	-0.8	-0.8	-1.6	-0.9	-0.9	0.4	-0.1	0.4	-0.1	0.1	0.2	0.2
Chronic bronchitis/emphysema (mother)	2.3	2.7	13.8	-0.2	2.2	2.0	0.3	1.3	3.5	0.7	0.9	2.1	3.7	0.8	-0.2	-0.2	1.6	-0.2	-0.2	1.5	0.9
High blood pressure (siblings)	1.1	1.6	5.3	-0.1	1.9	1.1	0.5	2.3	1.7	0.3	0.6	2.3	2.3	1.6	-0.4	-0.4	1.1	-0.4	-0.4	0.6	0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	5.4	1.4	-1.0	-1.2	0.2	-2.3	-0.5	-1.4	-1.6	-2.3	-0.6	-1.8	1.5	1.1	-0.1	1.1	1.3	-0.4	0.5
Body fat percentage	0.8	3.2	7.4	-2.2	1.6	1.9	-1.6	0.5	1.7	2.7	2.5	1.3	1.2	1.5	-1.7	-2.5	-0.2	-2.5	-2.5	0.9	-0.4
Leg fat percentage (right)	1.3	4.6	8.7	-2.4	2.2	2.2	-1.8	1.3	2.3	3.0	2.8	1.9	1.5	2.0	-2.0	-2.9	0.0	-2.9	-2.9	0.7	-0.6
Arm fat-free mass (right)	0.2	0.8	2.9	-1.3	0.6	0.7	-0.8	0.7	0.3	1.7	1.4	0.2	-0.6	0.9	-1.2	-0.7	-0.6	-0.7	-0.8	-0.3	-1.0
Exposure to tobacco smoke outside home	0.7	0.9	2.6	1.4	-0.5	-0.9	1.3	0.6	0.1	-1.6	-1.5	-0.1	0.5	-0.7	1.2	1.1	0.2	1.1	1.2	0.2	0.9
Comparative body size at age 10	1.2	3.2	9.4	-1.9	0.1	-0.5	-2.6	-0.5	-0.6	1.3	1.5	-3.1	-1.6	-1.3	-1.6	-2.1	-2.2	-2.1	-2.1	-2.1	-2.1
Number of full brothers	0.7	0.8	6.5	0.5	1.2	0.4	1.0	0.9	0.2	-0.2	-0.2	2.5	-0.1	-0.1	0.5	0.5	1.3	0.5	0.5	1.2	1.0
Worry too long after embarrassment	1.0	1.6	5.3	0.9	-1.5	-1.2	1.6	2.3	-1.1	-1.6	-1.2	0.1	0.6	-0.3	1.3	1.2	1.1	1.2	1.1	1.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.2	-0.6	-1.6	-1.8	-1.2	0.8	-1.4	0.2	-0.1	-1.3	-0.1	-0.9	-0.4	-1.2	-1.0	-1.2	-1.1	-1.3	-1.5
Wheeze or whistling in the chest in last year	0.3	0.5	2.3	-0.2	-0.7	-0.2	-0.3	1.5	-0.8	0.3	-0.3	-0.7	-0.2	-0.8	0.1	-0.9	-0.9	-0.9	-0.8	0.1	-0.1
Number of children fathered	0.8	0.9	3.5	-0.8	-0.3	-0.5	-1.2	0.2	-0.7	0.5	0.4	-0.8	-0.3	-1.7	-1.0	-0.8	-1.3	-0.8	-0.8	-1.9	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.5	-1.2	-0.0	0.2	-1.8	-1.8	-0.6	0.6	0.8	-1.6	-2.1	-1.1	-0.7	-0.8	-2.1	-0.8	-0.9	-1.7	-1.3
Age at first live birth	0.4	0.8	2.2	0.5	0.2	0.8	0.9	-1.4	0.5	-0.6	-0.2	0.6	1.4	1.3	0.3	1.5	0.3	1.5	1.3	0.2	0.3
Pulse wave peak to peak time	0.6	0.8	5.1	-0.4	1.1	1.2	-0.8	-2.2	1.0	0.4	0.8	-0.8	1.3	0.1	-0.5	0.4	-0.4	0.4	0.3	0.1	-0.1
Health satisfaction	0.7	0.8	4.8	0.6	-0.4	-0.3	-0.4	-1.1	-0.0	-0.6	-0.6	-1.0	1.7	-2.2	0.6	1.1	-0.4	1.1	1.0	0.0	0.1
Shortness of breath walking on level ground	0.2	0.2	2.0	0.4	-0.0	-0.2	-0.4	-1.4	-0.3	-0.1	-0.3	0.0	0.6	-0.6	0.5	-0.0	0.8	-0.0	0.1	0.0	-0.0
Qualifications: College or University degree	0.4	1.2	3.2	1.7	-0.8	-0.1	1.5	-0.9	-0.6	-1.7	-1.4	-0.4	1.0	1.8	0.8	1.1	0.9	1.1	1.3	-0.1	-0.1
Eye problems/disorders: None of the above	0.8	1.0	3.8	0.4	-1.2	-1.7	0.0	-1.1	-1.4	-0.8	-0.8	-0.9	-2.0	-0.3	0.5	0.8	-1.2	0.8	0.8	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.1	0.2	1.0	1.4	0.4	0.3	1.3	0.1	0.3	1.4	0.8	1.3	-0.3	-0.3	0.9	-0.3	-0.2	0.4	0.0
Emphysema/chronic bronchitis	0.5	0.5	1.4	-0.7	0.7	0.3	-1.2	-0.4	0.9	0.8	0.7	-0.0	-0.2	-1.1	-0.4	-1.0	-0.2	-1.0	-0.9	-0.1	-0.1
Medication for pain relief, constipation, heartburn	0.7	1.3	3.8	0.9	-0.9	-1.1	1.2	0.6	-1.8	-1.2	-0.9	0.1	-2.0	-0.7	0.5	1.6	0.6	1.6	1.5	-0.7	-0.3
Neck or shoulder pain in last month	0.6	0.9	2.9	-0.7	-0.7	-0.2	-1.4	0.4	-1.3	0.9	-0.1	-0.9	0.9	-1.7	-0.3	-1.0	-0.8	-1.0	-0.9	-1.1	-0.8
Medication: Blood pressure	1.0	1.8	10.8	1.1	0.6	1.2	1.2	-0.6	1.6	-0.8	-0.8	0.9	3.3	-0.6	0.9	1.6	0.1	1.6	1.5	1.1	1.4
Angina (self-reported)	0.5	0.7	3.5	-0.6	-0.1	0.3	-1.1	-1.9	-0.4	0.5	0.6	-1.8	-0.0	-0.8	-0.7	0.0	-1.0	0.0	-0.1	-0.9	-0.9
Migraine (self-reported)	2.1	2.6	4.9	-1.6	1.3	1.7	-0.8	1.4	0.9	2.0	1.7	1.7	0.5	2.2	-2.1	-1.8	-0.8	-1.8	-1.9	-1.3	-1.7
Medication: Ibuprofen	0.1	0.2	0.8	-0.2	0.1	0.3	-0.6	-0.8	0.9	0.6	0.0	0.4	0.1	-0.1	-0.1	-0.3	-0.6	-0.3	-0.3	-0.4	-0.0
Medication: Allopurinol	0.8	1.1	3.9	0.1	-2.0	-1.7	0.1	0.1	-1.9	-0.3	-0.9	-1.0	-1.3	-1.6	0.4	0.2	-1.5	0.2	0.2	-0.5	-0.4
Medication: Omeprazole	0.5	0.6	2.5	-0.3	-0.0	0.1	-0.7	-1.1	1.4	0.4	0.1	-1.0	0.6	-1.6	0.4	0.0	-0.1	0.0	-0.0	1.3	0.9
Medication: Seretide 50 evohaler	2.0	2.4	6.0	1.4	2.2	1.8	1.5	0.5	1.7	-1.4	-0.4	1.0	2.5	0.0	1.1	1.3	1.6	1.3	1.4	1.9	2.3
Mean time to correctly identify matches	0.5	0.9	8.9	-0.8	-1.3	-0.6	0.2	3.0	-0.5	-0.1	0.1	0.0	0.4	0.4	-0.5	-0.5	-1.6	-0.5	-0.6	-0.3	-0.5
Heart disease (mother)	0.3	0.4	3.4	0.1	0.3	0.4	-0.2	-0.6	0.1	-0.2	0.1	0.4	1.9	1.4	-0.1	0.4	0.4	0.4	0.4	0.5	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.2	0.2	0.8	-0.1	0.6	0.8	1.1	-0.2	0.1	0.5	0.2	0.3	0.1	0.6	0.5	0.6	0.5	0.7	0.8
Whole body fat mass	0.8	3.3	8.9	-2.4	1.4	1.6	-1.8	0.8	1.4	3.0	2.6	1.0	0.7	1.7	-2.0	-2.4	-0.6	-2.4	-2.5	0.4	-0.8
Leg fat mass (right)	1.0	3.8	9.2	-2.6	1.6	1.6	-2.0	0.9	1.5	3.0	2.8	0.9	0.5	1.8	-2.2	-2.6	-0.6	-2.6	-2.7	0.1	-1.1
Arm predicted mass (right)	0.2	0.8	3.0	-1.4	0.5	0.5	-1.0	0.6	0.2	1.7	1.5	0.0	-0.6	0.9	-1.3	-0.7	-0.6	-0.7	-0.9	-0.4	-1.0
Pulse rate, automated reading	1.0	3.1	9.1	0.6	2.1	1.9	1.1	1.4	3.0	0.1	0.3	2.2	2.8	1.1	0.6	-0.0	2.9	-0.0	0.1	3.0	2.0
Alcohol intake frequency.	0.9	2.0	13.0	-0.7	-0.5	-0.2	-1.8	-3.6	-1.5	0.7	0.3	-1.4	-0.7	-1.9	-0.4	-0.4	-2.2	-0.4	-0.4	-1.6	-1.3
Comparative height size at age 10	1.1	6.1	13.8	-2.5	-1.7	-1.1	-3.1	0.3	-1.8	2.5	1.3	-2.4	-2.0	-2.4	-2.3	-2.5	-3.5	-2.5	-2.5	-3.5	-3.7
Number of full sisters	1.3	1.6	5.8	0.8	-1.2	-0.7	0.2	-1.7	-1.6	-1.0	-1.1	-1.0	-1.7	-2.4	1.1	1.6	-0.2	1.6	1.5	0.2	0.6
Suffer from ‘nerves’	0.7	1.0	2.0	1.2	-0.7	-1.3	0.9	0.4	-1.1	-1.4	-1.3	-0.4	1.2	-1.2	1.0	1.2	0.6	1.2	1.2	0.2	0.7
Overall health rating	0.7	1.4	10.0	0.9	0.3	0.7	-0.5	-2.0	0.8	-0.7	-0.9	0.9	3.2	-2.2	0.9	0.3	-0.4	0.3	0.5	0.3	0.5
Chest pain or discomfort	1.1	1.6	4.9	-0.6	1.8	2.2	-1.0	-1.4	1.6	1.1	1.1	0.1	2.2	0.1	-0.8	-1.6	-0.1	-1.6	-1.4	-0.3	-0.7
Had major operations	0.8	0.9	1.9	1.4	0.2	0.2	1.2	-0.9	0.5	-1.3	-1.1	0.4	1.0	0.1	0.9	1.3	1.0	1.3	1.4	0.2	0.6
Age at last live birth	1.3	1.9	4.5	1.0	1.0	1.7	1.5	-0.4	1.4	-1.0	-0.3	0.5	2.1	1.0	0.8	1.8	1.7	1.8	1.7	1.5	1.5
Family relationship satisfaction	0.1	0.2	0.9	-0.0	-0.1	-0.5	0.1	0.3	-0.3	-0.2	-0.1	-0.3	-0.3	-1.0	0.0	0.8	-0.3	0.8	0.6	-0.3	-0.0
Leg pain on walking	1.1	1.3	2.4	1.1	-1.5	-1.3	0.7	-1.0	-1.6	-1.1	-1.5	0.5	0.9	-1.2	1.3	1.5	-0.3	1.5	1.5	0.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.2	-0.5	-0.5	-0.4	-0.2	-0.1	-0.5	-0.1	-0.6	0.5	-0.1	0.2	-0.3	0.7	-0.3	-0.2	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	4.0	0.0	-0.2	-0.2	0.3	2.0	0.1	-0.3	0.0	-0.3	-0.9	0.7	-0.0	-1.0	0.8	-1.0	-0.8	0.5	0.5
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	8.9	-2.5	1.1	-0.3	-1.7	0.3	0.4	2.5	2.6	-0.7	-3.0	1.3	-2.8	-2.0	-0.8	-2.0	-2.2	-2.1	-2.5
Medication: Aspirin	1.1	1.4	4.7	-0.7	1.6	2.2	-0.4	-0.3	1.9	0.9	1.3	0.2	1.5	2.0	-1.1	-1.0	0.2	-1.0	-0.9	0.4	-0.4
Supplements: Vitamin C	1.4	1.6	3.5	-1.2	-0.9	-1.0	-1.2	0.9	-0.8	1.3	0.7	-0.5	-0.3	0.8	-1.4	-1.9	-1.6	-1.9	-1.8	-1.4	-1.7
Knee pain experienced in last month	0.6	1.0	5.2	0.7	-1.6	-1.4	-0.4	-0.5	-1.8	-0.9	-1.2	0.0	-0.2	-2.3	1.0	0.1	-0.1	0.1	0.3	0.1	0.0
Hypertension (Self-reported)	1.5	4.0	13.8	1.9	1.3	1.2	2.6	1.2	1.8	-1.5	-1.2	3.2	3.7	1.0	1.4	1.8	2.1	1.8	1.9	2.1	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	6.0	0.3	-0.7	-0.4	-0.1	-1.2	-0.1	-0.1	-0.7	-0.8	0.7	-2.5	1.2	1.0	-0.7	1.0	0.9	1.0	1.2
Illnesses of father: Heart disease	1.9	2.6	6.9	1.0	2.4	2.1	0.8	-1.1	2.5	-0.8	0.1	1.5	2.6	1.7	0.7	0.8	2.6	0.8	0.9	2.0	1.5
Illnesses of siblings: Diabetes	1.9	2.3	7.2	0.4	2.3	2.5	0.8	-0.2	2.4	0.2	0.6	1.5	2.7	2.4	-0.1	0.4	1.6	0.4	0.4	1.8	1.1
Smoking status: Previous	0.8	1.3	3.2	-1.2	-0.1	0.1	-1.4	1.6	0.1	1.1	0.9	-1.0	-1.4	-0.7	-0.9	-1.8	-0.7	-1.8	-1.7	-0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.1	0.9	-0.5	-0.1	1.2	0.5	-0.2	-1.1	-0.9	-0.5	1.2	0.0	1.1	1.8	0.2	1.8	1.6	1.0	1.2
Whole body fat-free mass	0.2	1.3	3.5	-1.6	0.4	0.5	-1.3	0.3	0.2	1.9	1.6	-0.4	-1.2	0.7	-1.5	-1.0	-1.2	-1.0	-1.1	-0.8	-1.4
Leg fat-free mass (right)	0.2	0.9	2.0	-1.2	0.2	0.4	-1.3	-0.9	-0.2	1.4	1.3	-1.1	-1.4	0.3	-1.0	-0.6	-1.3	-0.6	-0.8	-0.5	-1.0
Arm fat percentage (left)	0.6	2.3	5.9	-2.0	1.3	1.4	-1.6	-0.3	1.4	2.4	2.3	0.5	0.5	1.5	-1.5	-2.0	-0.3	-2.0	-2.0	0.6	-0.4
Average weekly red wine intake	0.2	0.3	1.7	0.1	0.8	0.8	0.0	-1.2	1.3	0.2	0.2	0.5	-0.0	0.8	-0.1	0.2	-0.0	0.2	0.1	-0.1	-0.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.5	-0.9	-1.2	-0.8	-0.7	1.3	-1.0	0.8	0.2	-1.4	-0.3	-1.2	-0.5	-0.4	-1.6	-0.4	-0.5	-0.4	-0.4
Mood swings	0.2	0.4	1.7	-0.0	1.1	0.9	-0.3	-0.6	0.9	-0.2	0.3	-0.6	0.9	-1.3	0.3	-0.5	0.0	-0.5	-0.4	0.6	0.8
Loneliness, isolation	0.8	1.2	5.0	-0.8	1.9	2.2	-0.5	-0.3	1.3	1.0	1.4	0.7	1.5	0.2	-1.1	-0.8	0.6	-0.8	-0.9	-0.1	-0.4
Long-standing illness, disability or infirmity	1.0	1.5	10.5	0.3	1.5	1.9	-0.5	-3.2	1.3	0.1	0.3	1.4	2.4	-0.8	-0.2	0.1	-0.3	0.1	0.2	-0.2	-0.6
Ever had bowel cancer screening	0.7	0.8	2.5	0.5	1.0	1.6	0.7	-0.1	1.2	-0.4	0.0	1.0	1.3	-0.1	0.2	0.7	1.1	0.7	0.7	1.1	1.0
Diabetes diagnosed by doctor	1.5	2.4	6.2	1.9	0.7	1.5	1.1	-2.5	1.4	-1.5	-1.1	0.3	2.4	-0.2	1.3	1.9	0.9	1.9	2.0	1.5	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.6	1.4	-0.8	-1.0	0.6	1.3	-0.6	-1.6	-1.5	-0.1	0.3	-1.5	1.2	0.2	0.8	0.2	0.5	0.2	0.7
Friendships satisfaction	0.1	0.1	0.5	-0.1	-0.0	0.4	-0.1	-0.5	0.0	0.3	0.1	0.4	0.7	-0.6	0.1	0.5	-0.3	0.5	0.3	0.4	0.1
Qualifications: nursing, teaching	0.3	0.5	2.5	-0.3	0.8	0.6	-0.6	-1.4	0.6	-0.1	0.7	-0.7	-0.7	1.6	-0.7	-0.1	-0.3	-0.1	-0.2	-0.2	-0.4
Commuting to job workplace: Walk	1.7	1.9	4.7	-0.1	-2.2	-2.1	-0.9	0.1	-2.2	-0.2	-0.7	-2.0	-1.4	-1.9	-0.0	0.4	-1.9	0.4	0.3	-1.8	-1.3
Eye problems/disorders: Cataract	0.6	0.7	1.9	-1.0	1.0	1.4	-0.8	-0.1	0.8	1.1	1.2	0.1	1.0	0.0	-1.0	-0.9	-0.6	-0.9	-0.9	-0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	9.2	1.3	-3.0	-2.6	0.6	-0.1	-2.6	-1.7	-2.4	-1.7	-1.8	-2.2	1.8	0.8	-1.3	0.8	1.0	-0.9	0.1
Medication for cholesterol	0.5	0.8	4.3	-0.4	-0.8	-1.1	-0.5	-0.2	-0.8	0.1	-0.1	-2.1	-1.4	-1.5	-0.2	0.2	-1.3	0.2	0.0	-0.9	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	-0.0	0.9	0.8	-0.2	-0.4	1.0	-0.1	0.4	0.3	-0.3	0.6	-0.3	-0.5	0.6	-0.5	-0.4	-0.3	-0.3
Back pain experienced in last month	0.9	1.3	2.5	1.4	-0.5	-0.0	0.7	-1.2	-0.4	-1.4	-1.4	-0.6	1.1	-1.1	1.6	1.4	-0.1	1.4	1.5	1.3	1.4
Mineral and other dietary supplements	0.4	0.5	3.7	0.1	-0.4	-0.1	0.2	-1.5	0.1	0.0	-0.0	-1.9	-0.8	-0.5	0.0	0.9	-0.3	0.9	0.7	0.2	0.2
Breast cancer (self-reported)	0.5	0.6	1.5	0.8	-1.2	-0.7	0.6	-0.2	-0.5	-1.1	-0.9	-0.0	-1.2	-0.9	0.8	0.8	0.5	0.8	0.9	0.2	0.3
Asthma (self-reported)	0.2	0.4	3.0	0.7	1.2	0.9	0.4	-1.7	0.6	-0.7	-0.1	-0.1	-0.1	0.4	0.3	0.4	0.4	0.4	0.5	-0.0	0.5
Osteoporosis (self-reported)	0.3	0.4	1.5	0.1	0.7	-0.2	-0.2	1.1	0.3	-0.2	0.1	1.0	-0.9	-1.2	0.1	-0.8	0.6	-0.8	-0.6	0.1	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.5	0.3	-0.2	0.4	0.0	0.2	-0.2	-0.2	-0.1	0.2	-0.5	0.0	-0.0	-0.5	0.7	-0.5	-0.4	-0.2	-0.3
Medication: Aspirin	1.1	1.5	3.3	-1.0	1.4	1.8	-1.0	-0.8	1.5	1.1	1.5	-0.2	1.3	1.5	-1.4	-1.4	-0.4	-1.4	-1.3	-0.3	-1.1
Medication: Gliclazide	0.5	0.6	3.2	1.0	1.2	0.9	-0.1	-1.8	1.2	-0.8	-0.5	-0.5	-0.5	0.2	0.7	-0.0	0.2	-0.0	0.2	-0.2	0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	4.9	-1.2	-1.1	0.1	-0.9	0.2	-1.3	1.3	0.7	-0.3	-2.2	-0.6	-1.0	-0.5	-1.4	-0.5	-0.6	-1.2	-1.0
Smoking status: Current	2.3	3.6	9.6	-2.3	0.7	-0.1	-1.8	3.1	1.1	2.6	1.8	-0.4	0.0	0.6	-2.0	-3.0	-1.1	-3.0	-2.9	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	6.9	1.0	1.0	0.7	0.3	-2.6	1.1	-0.8	-0.4	-1.2	-0.4	-0.2	0.6	0.8	1.3	0.8	0.9	-0.2	0.4
Whole body water mass	0.3	1.5	4.0	-1.7	0.4	0.6	-1.4	0.3	0.2	2.0	1.7	-0.4	-1.3	0.7	-1.6	-1.1	-1.2	-1.1	-1.2	-1.0	-1.5
Leg predicted mass (right)	0.2	1.0	2.1	-1.3	0.2	0.4	-1.4	-0.9	-0.2	1.4	1.3	-1.1	-1.4	0.4	-1.0	-0.7	-1.3	-0.7	-0.8	-0.5	-1.0
Arm fat mass (left)	0.4	1.8	5.6	-2.0	1.0	1.0	-1.5	-0.1	1.0	2.4	2.1	0.1	0.1	1.1	-1.4	-1.7	-0.6	-1.7	-1.8	0.3	-0.6
Number of self-reported non-cancer illnesses	1.0	1.8	8.1	1.7	1.1	1.7	1.2	-1.2	1.6	-1.3	-1.0	1.4	2.9	-0.0	1.1	0.7	1.1	0.7	1.0	1.1	1.3
Average weekly champagne plus white wine intake	1.4	1.9	4.0	1.8	0.4	0.6	2.0	0.8	1.3	-1.6	-1.4	0.5	1.8	0.2	1.5	1.4	1.6	1.4	1.5	1.2	1.9
Miserableness	0.5	0.9	5.8	-0.1	1.0	1.4	-0.3	0.1	1.4	-0.2	0.2	-0.4	2.4	-1.9	0.5	0.2	0.0	0.2	0.1	0.8	1.0
Guilty feelings	0.8	1.2	3.4	-1.1	-0.9	-0.0	-1.7	-0.4	-0.8	0.7	0.4	-1.0	-0.4	-1.9	-0.5	-1.2	-1.5	-1.2	-1.2	-1.4	-1.1
Wears glasses or contact lenses	2.5	2.9	9.6	-1.4	-1.3	-0.7	-2.0	-2.6	-1.6	1.3	0.6	0.4	-1.5	0.4	-1.5	-1.5	-1.9	-1.5	-1.4	-3.1	-2.9
Ever taken oral contraceptive pill	0.4	0.4	1.6	-0.5	0.4	1.1	-0.4	-0.7	1.3	0.8	0.6	-0.3	0.6	1.2	-0.4	-0.4	-0.4	-0.4	-0.4	0.4	0.0
Hearing aid user	1.9	2.1	5.7	-2.2	0.6	0.7	-1.7	0.9	0.7	2.4	2.0	-1.0	-0.9	-0.0	-1.7	-1.9	-1.3	-1.9	-2.0	-0.2	-0.8
Mother’s age at death	0.4	0.5	5.0	0.4	-0.6	-0.4	0.9	2.2	-0.0	-0.1	-0.4	1.1	0.4	0.5	0.2	0.4	0.4	0.4	0.3	0.7	0.6
Financial situation satisfaction	0.2	0.3	3.1	0.4	-0.3	-0.7	-0.3	-0.1	-0.4	-0.3	-0.7	0.1	-0.2	-1.8	0.6	0.1	-0.5	0.1	0.2	-0.3	0.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	-0.6	-1.1	-1.2	-0.8	1.4	-1.4	0.7	0.0	-0.9	-1.4	-1.5	-0.2	-1.4	-0.2	-1.4	-1.3	-0.6	-0.7
Commuting to job workplace: Public transport	0.5	0.6	4.6	0.7	-0.4	-0.4	0.2	-2.1	-0.7	-0.3	-0.7	0.9	0.2	0.4	0.4	1.0	-0.5	1.0	1.0	0.0	-0.0
Eye problems/disorders: Glaucoma	0.4	0.5	2.6	0.7	-0.5	0.2	0.8	1.2	-0.5	-0.5	-0.9	1.6	1.2	0.1	0.7	0.3	0.6	0.3	0.4	0.2	0.5
Medication: Blood pressure	0.9	1.8	8.7	1.2	0.8	0.8	1.4	1.3	1.1	-0.9	-0.6	2.9	0.9	1.8	0.8	0.4	2.3	0.4	0.6	1.6	1.0
Pain type(s) experienced in last month: Hip pain	2.1	2.7	5.3	-2.2	0.3	0.7	-2.2	0.6	-0.1	2.0	1.8	-1.9	-1.1	-0.8	-1.6	-2.2	-2.0	-2.2	-2.3	-1.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	-0.7	0.2	0.4	-0.8	0.9	-0.3	0.7	0.5	0.7	-0.2	0.3	-0.7	-1.2	-0.6	-1.2	-1.1	-1.1	-0.9
High cholesterol (Self-reported)	0.3	0.5	3.5	0.4	0.1	0.6	0.6	0.1	0.6	-0.3	-0.3	0.8	1.9	-0.0	0.4	0.2	1.1	0.2	0.2	1.0	0.8
Medication: Bendroflumethiazide	2.9	4.4	11.4	2.1	1.9	1.6	2.7	1.5	2.2	-1.4	-0.9	2.4	2.3	1.4	1.7	1.4	3.4	1.4	1.5	3.3	2.8
Medication: Paracetamol	0.4	0.7	3.0	-0.5	-0.2	0.1	-1.0	-0.8	0.1	0.6	0.1	-0.4	0.7	-0.5	0.0	-1.7	-0.8	-1.7	-1.5	0.1	0.1
Medication: Lisinopril	1.7	2.2	3.8	1.7	-0.8	-0.3	1.9	1.4	0.1	-1.4	-1.6	1.9	1.7	-0.5	1.6	1.8	1.3	1.8	1.8	1.6	1.3
Medication: Atorvastatin	0.9	1.1	3.3	-1.2	1.6	1.8	-0.5	-0.7	1.2	1.0	1.7	0.6	0.4	0.5	-1.5	-0.7	-0.3	-0.7	-0.8	-0.5	-0.8
Illnesses of father: High blood pressure	1.5	1.8	5.7	2.0	-0.7	-1.3	1.7	0.0	0.1	-2.4	-2.0	-0.3	1.5	-0.9	1.5	1.5	1.1	1.5	1.6	0.4	0.8
Alcohol drinker status: Never	1.2	1.4	5.6	-1.0	0.0	-0.0	-1.3	-2.4	-0.7	0.6	0.7	-1.0	0.1	-0.1	-1.1	-0.6	-1.3	-0.6	-0.7	-2.3	-2.3
Ever smoked	2.5	4.4	10.2	-2.4	-0.3	-0.5	-2.2	2.7	-0.3	2.3	1.6	-1.5	-2.0	0.1	-2.1	-3.2	-1.9	-3.2	-3.2	-2.2	-1.9
Basal metabolic rate	0.3	1.5	4.1	-1.8	0.4	0.5	-1.6	0.2	0.1	2.0	1.7	-0.5	-1.2	0.7	-1.5	-1.2	-1.3	-1.2	-1.4	-0.8	-1.4
Leg fat percentage (left)	1.1	3.9	7.6	-2.2	2.1	2.3	-1.6	1.0	2.2	2.8	2.6	1.8	1.7	1.6	-1.8	-2.6	-0.2	-2.6	-2.6	0.9	-0.3
Arm fat-free mass (left)	0.2	1.1	3.5	-1.6	0.4	0.5	-1.3	0.3	0.1	1.9	1.6	-0.0	-0.9	0.5	-1.5	-0.8	-1.1	-0.8	-1.1	-0.8	-1.4
Number of operations (self-reported)	1.8	2.6	5.3	2.3	-0.8	-1.0	1.8	0.5	-0.2	-2.3	-2.3	-0.7	0.9	-1.8	2.1	1.9	1.5	1.9	2.1	0.9	1.5
Average weekly beer plus cider intake	0.8	1.2	3.9	-1.1	-1.4	-0.7	-0.6	1.3	-2.0	0.8	0.3	-0.1	-0.9	0.6	-1.1	-0.6	-1.5	-0.6	-0.7	-1.6	-1.7
Irritability	1.2	2.0	8.3	1.0	1.5	1.6	0.9	0.5	2.0	-1.0	-0.2	1.7	2.9	0.9	0.8	1.0	1.4	1.0	1.0	1.9	1.7
Risk taking	0.3	0.5	1.8	-0.1	1.4	1.3	-0.0	-1.0	1.1	0.2	0.6	0.6	-0.4	1.2	-0.2	-0.3	0.4	-0.3	-0.3	0.4	0.1
Ever had prostate specific antigen (PSA) test	1.6	1.8	6.0	-1.0	2.0	2.5	-1.1	-0.3	2.1	1.2	1.6	-0.0	0.4	1.2	-1.2	-1.7	-0.1	-1.7	-1.6	0.0	-0.3
Fractured/broken bones in last 5 years	0.2	0.3	1.1	0.7	0.5	0.3	0.6	0.1	0.9	-0.2	-0.4	0.5	0.7	0.1	0.3	-0.5	1.1	-0.5	-0.3	0.1	0.1
Age started oral contraceptive pill	0.3	0.4	2.5	0.1	1.0	0.2	-0.0	-1.3	0.2	-0.0	0.4	0.6	-0.0	0.8	-0.2	0.0	1.6	0.0	0.0	0.0	0.1
Diastolic blood pressure, automated reading	0.5	1.7	7.0	1.6	-0.4	-1.1	1.9	1.1	-0.6	-1.6	-1.7	2.6	0.1	0.2	1.6	1.1	1.1	1.1	1.2	0.4	1.0
Ever depressed for a whole week	0.5	0.6	2.0	-0.6	-0.4	-0.5	-1.2	-0.0	0.6	0.6	0.1	-0.0	1.4	-0.9	-0.3	-1.0	-0.6	-1.0	-0.9	-1.0	-1.0
Unable to work because of sickness or disability	0.5	0.7	2.2	-0.5	0.6	0.4	-1.0	-0.1	0.0	0.6	0.4	-0.1	1.5	-0.8	-0.5	-1.4	-0.6	-1.4	-1.2	-0.3	-0.8
Commuting to job workplace: Cycle	1.3	1.6	5.9	0.6	-1.8	-1.9	0.8	-0.3	-2.4	-0.7	-1.1	-2.2	-0.0	-1.2	0.5	1.5	-0.6	1.5	1.3	-0.6	0.0
Myopia	1.7	2.4	13.2	-0.3	-1.6	-0.7	-1.3	-3.6	-1.6	0.0	-0.7	-2.0	-0.9	-1.6	0.1	0.4	-2.8	0.4	0.3	-2.4	-1.1
Vascular/heart problems diagnosed by doctor	0.8	2.2	8.9	-1.4	-1.0	-1.0	-1.9	-0.6	-1.3	1.0	0.8	-2.7	-3.0	-0.7	-0.9	-1.4	-1.5	-1.4	-1.4	-1.3	-1.2
Cholesterol lowering medication	0.4	0.5	2.7	0.1	0.7	0.9	0.6	1.1	0.5	-0.1	0.2	1.6	1.1	0.4	-0.0	0.2	1.1	0.2	0.2	0.9	0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.3	0.0	0.2	0.2	-0.1	-1.3	1.4	0.1	0.0	-0.7	1.2	-0.9	0.6	0.3	0.6	0.3	0.3	1.8	1.3
Pain experienced in last month	1.6	2.7	5.8	-2.1	1.5	0.8	-1.2	0.4	1.5	1.9	2.2	1.0	-1.1	1.4	-2.4	-1.7	-0.8	-1.7	-1.8	-2.0	-2.2
Supplements: Calcium	1.1	1.2	3.4	-1.2	1.0	0.0	-1.4	-0.4	1.4	1.0	1.2	0.0	-0.7	0.0	-0.8	-1.8	-0.3	-1.8	-1.7	-0.6	-0.7
Basal cell carcinoma (self-reported)	1.2	1.4	3.7	1.5	-0.5	-0.2	1.6	0.9	-0.0	-1.6	-1.2	1.9	-0.1	0.1	1.4	1.3	1.3	1.3	1.3	1.1	1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	6.2	-0.3	1.1	1.4	-0.5	-2.5	1.8	0.2	0.5	-0.6	1.4	0.1	-0.1	0.1	-0.5	0.1	0.1	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	6.6	1.0	1.4	1.5	1.3	1.2	1.1	-0.8	-0.1	1.8	2.6	0.6	0.6	0.7	2.0	0.7	0.8	1.8	1.4
Heart disease (siblings)	0.1	0.2	1.0	0.2	0.2	-0.0	-0.3	-1.0	0.1	-0.6	-0.2	-0.4	-0.1	-0.8	0.2	0.2	0.1	0.2	0.2	0.3	0.4
Alcohol drinker status: Previous	0.6	0.7	3.6	0.8	-0.8	-0.3	-0.2	-1.9	-0.6	-0.8	-1.3	0.7	1.0	-1.3	1.0	0.1	-1.0	0.1	0.3	-0.6	0.1
Pack years of smoking	0.4	0.6	2.8	-0.5	0.9	0.8	-0.3	0.0	0.9	0.9	0.8	1.7	0.0	0.1	-0.7	-1.1	0.6	-1.1	-1.0	-0.2	-0.5
Impedance of whole body	0.2	1.0	3.3	1.2	-0.1	0.2	1.3	1.3	0.1	-1.1	-1.0	0.2	1.8	-0.2	1.0	0.2	1.3	0.2	0.4	1.4	1.5
Leg fat mass (left)	0.9	3.4	8.6	-2.5	1.5	1.6	-1.9	0.8	1.5	2.9	2.7	0.8	0.6	1.5	-2.1	-2.5	-0.7	-2.5	-2.6	0.2	-1.0
Arm predicted mass (left)	0.3	1.5	4.5	-1.9	0.6	0.7	-1.5	0.4	0.3	2.1	1.8	-0.0	-0.9	0.6	-1.7	-1.1	-1.0	-1.1	-1.4	-0.9	-1.5