Hub : Genes

AP4B1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1530 0.0340 2.1e-14 0.199 0.156 0.184 0.195 0.196 9.1e-24 1.7e-18 8.1e-22 3.0e-23 2.4e-23
2 GTEx Artery Tibial 0.0910 0.0383 3.4e-03 0.128 NA 0.124 NA 0.127 3.1e-10 NA 6.1e-10 NA 4.1e-10
3 GTEx Brain Cerebellar Hemisphere 0.2860 0.0960 3.1e-03 0.225 NA 0.128 NA 0.142 1.9e-06 NA 3.7e-04 NA 1.8e-04
4 GTEx Cells Transformed fibroblasts 0.2100 0.0470 4.1e-09 0.144 NA 0.154 NA 0.138 6.5e-11 NA 1.3e-11 NA 1.6e-10
5 GTEx Esophagus Gastroesophageal Junction 0.1350 0.0590 4.6e-03 -0.004 NA -0.001 NA 0.005 4.9e-01 NA 3.7e-01 NA 2.0e-01
6 GTEx Nerve Tibial 0.2267 0.0709 1.3e-04 0.086 NA 0.082 NA 0.083 1.1e-06 NA 2.1e-06 NA 1.8e-06
7 GTEx Spleen 0.2700 0.0970 4.8e-03 0.208 NA 0.091 NA 0.185 4.9e-06 NA 2.5e-03 NA 1.7e-05
8 GTEx Whole Blood 0.0970 0.0340 3.2e-04 0.078 NA 0.063 NA 0.058 1.1e-07 NA 1.9e-06 NA 4.3e-06
9 METSIM Adipose 0.0557 0.0256 4.9e-03 0.007 0.012 0.008 0.015 0.008 2.3e-02 6.2e-03 2.1e-02 2.2e-03 2.2e-02
10 ROSMAP Brain Pre-frontal Cortex 0.0899 0.0282 5.0e-06 0.029 0.047 0.022 0.046 0.043 1.1e-04 9.1e-07 5.8e-04 1.3e-06 2.8e-06
11 YFS Blood 0.0921 0.0220 2.1e-14 0.031 0.047 0.036 0.046 0.035 2.0e-10 5.3e-15 8.1e-12 6.8e-15 1.5e-11
12 TCGA Breast Invasive Carcinoma 0.0579 0.0255 3.2e-09 0.057 0.048 0.051 NA 0.051 7.8e-12 3.6e-10 1.0e-10 NA 1.2e-10
13 TCGA Kidney Renal Clear Cell Carcinoma 0.0535 0.0271 1.0e-04 0.062 0.051 0.057 NA 0.060 1.6e-07 2.0e-06 5.4e-07 NA 2.6e-07
14 TCGA Brain Lower Grade Glioma 0.1634 0.0798 3.0e-07 0.017 0.058 0.059 NA 0.042 4.0e-03 3.3e-07 2.6e-07 NA 1.4e-05
15 TCGA Lung Adenocarcinoma 0.0837 0.0362 5.7e-05 0.059 0.047 0.046 NA 0.050 2.0e-07 3.4e-06 4.2e-06 NA 1.6e-06
16 TCGA Prostate Adenocarcinoma 0.0784 0.0365 8.5e-05 0.068 0.035 0.059 NA 0.064 1.3e-07 1.4e-04 8.2e-07 NA 3.2e-07
17 TCGA Soft Tissue Sarcoma 0.0910 0.0500 1.4e-03 0.003 0.049 0.035 NA 0.024 1.9e-01 6.6e-04 3.4e-03 NA 1.4e-02
18 TCGA Thyroid Carcinoma 0.0880 0.0450 9.2e-05 0.037 0.039 0.025 NA 0.035 1.6e-04 9.6e-05 1.6e-03 NA 2.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 1.5 2.4 6.5 -1.6 1.1 0.4 -2.6 -1.4 1.0 1.4 1.5 -0.6 -0.2 0.4 -1.5 -2.3 -0.9 -2.3 -2.2 -1.8 -1.8
Bipolar Disorder or Schizophrenia 1.0 2.5 4.3 -1.7 1.9 1.7 -1.7 -1.9 1.7 1.9 2.1 0.0 1.0 2.0 -1.8 -1.7 -0.3 -1.7 -1.8 -0.6 -1.2
Depressed Affect (Nagel 2018) 0.3 0.6 5.6 0.1 0.1 1.0 -0.5 -0.5 0.3 -0.4 -0.2 -0.5 1.2 -2.4 0.4 -0.3 -0.5 -0.3 -0.2 0.0 0.4
Depression (Nagel 2018) 0.6 0.9 2.9 -0.4 0.3 1.4 -1.0 0.5 -0.0 0.6 0.1 0.1 1.7 -1.2 0.0 -1.7 -0.5 -1.7 -1.4 0.3 0.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.4 1.4 -2.0 -2.0 1.0 0.8 -1.2 -1.5 -1.9 -1.8 -2.1 -1.2 1.5 0.8 0.1 0.8 0.9 0.1 0.6
Neuroticism (Nagel 2018) 0.4 0.9 3.2 0.7 -0.5 0.3 0.4 0.7 0.0 -1.1 -0.8 -0.4 1.8 -1.7 1.2 0.8 0.2 0.8 0.8 1.0 1.3
Schizophrenia (2018) 0.6 1.3 5.4 -0.9 1.6 1.8 -0.1 -1.4 1.3 1.3 1.4 0.5 1.4 2.3 -1.0 -0.4 0.1 -0.4 -0.5 0.7 -0.1
Schizophrenia vs Biploar Disorder 0.1 0.2 0.9 0.2 -0.6 0.1 0.1 -0.1 -0.7 -0.2 -0.4 -0.1 -0.2 -0.5 0.4 0.6 -1.0 0.6 0.5 -0.3 0.1
Worry (Nagel 2018) 1.0 2.2 6.7 1.6 0.6 0.6 1.5 0.4 0.9 -1.9 -1.0 0.5 2.6 0.2 1.6 1.6 1.7 1.6 1.6 2.0 2.0
Alzheimer’s Disease (in mother) 0.5 0.6 2.7 -1.0 -0.5 0.7 -0.6 0.4 0.0 0.8 0.5 -0.7 0.2 -1.0 -0.6 -0.8 -1.6 -0.8 -0.8 -0.6 -0.5
Alzheimer’s Disease (in father) 0.5 0.6 4.4 -0.5 -0.2 -0.4 -1.2 -2.1 -0.8 0.2 0.4 -0.4 -0.2 -0.5 -0.2 -0.6 -0.4 -0.6 -0.5 -1.0 -1.0
Alzheimer’s Disease (including proxy) 0.6 0.9 2.7 -0.7 -1.3 -0.5 -0.6 -1.2 -1.6 0.3 0.1 -1.5 -1.1 -1.6 -0.1 -0.1 -1.5 -0.1 -0.3 -1.0 -0.5
Crohns Disease (2017) 2.1 4.6 17.9 0.6 -4.2 -3.9 1.0 3.1 -4.2 -0.9 -2.2 -0.6 -2.3 -1.5 1.1 0.4 -1.5 0.4 0.4 -1.5 -0.9
Irritable Bowel Disease (IBD) 0.9 2.2 8.2 0.6 -2.6 -2.4 0.3 1.5 -2.9 -0.9 -1.6 -1.0 -1.9 -1.6 1.0 -0.1 -1.3 -0.1 0.1 -1.2 -0.7
Ulcerative Colitis (UC) 0.2 0.3 1.3 0.7 -0.2 0.0 -0.1 -0.5 -0.6 -0.9 -0.8 -1.1 -0.4 -0.9 0.7 -0.1 -0.4 -0.1 0.1 -0.3 0.0
Major Depression (MDD) 0.9 1.1 2.9 -1.0 -0.0 0.0 -1.7 -0.6 -0.2 0.7 0.8 -1.4 -0.8 -0.9 -0.8 -1.6 -1.1 -1.6 -1.5 -1.0 -1.0
Reaction Time 0.9 1.7 5.4 0.7 -2.3 -1.5 1.4 2.3 -1.7 -1.6 -1.5 -1.0 0.6 -0.5 1.1 1.0 -1.3 1.0 0.9 0.6 0.6
Verbal and Numeric Reasoning (VNR) 0.6 1.3 4.9 1.0 -1.7 -1.9 0.2 -0.0 -1.1 -1.3 -1.3 -2.2 -2.2 -0.9 1.1 0.2 -0.1 0.2 0.4 -0.3 0.1
Breast Cancer 1.9 4.7 16.3 -1.6 -2.5 -2.4 -1.1 4.0 -2.4 1.8 0.2 -0.9 -1.4 -0.8 -1.1 -3.1 -1.6 -3.1 -2.9 -2.2 -2.0
Ovarian Cancer 0.8 1.0 3.7 -0.1 1.5 1.6 0.7 1.9 1.1 0.2 0.4 1.5 1.5 0.7 0.2 0.3 0.7 0.3 0.2 1.1 1.2
Prostate Cancer 1.0 1.4 2.8 1.1 -1.1 -1.0 0.8 -1.4 -0.8 -1.4 -1.6 -0.5 -0.2 -1.6 1.7 1.4 -0.5 1.4 1.4 0.6 1.0
Age at First Birth 0.3 0.4 1.3 0.4 0.5 0.1 0.4 -1.1 0.7 -0.5 -0.1 0.6 0.5 0.6 0.1 1.1 -0.0 1.1 1.0 -0.1 0.0
Bipolar Disorder (2011) 1.3 1.3 4.7 -0.5 1.7 1.3 -0.9 -2.2 1.5 0.7 1.1 -0.7 1.8 1.5 -0.7 -0.9 0.4 -0.9 -0.8 0.4 -0.1
Body Mass Index (BMI) (2010) 1.2 1.7 4.8 -0.5 -1.9 -2.0 -0.7 -0.4 -2.2 0.2 -0.5 -0.8 -2.2 -1.5 -0.2 -0.1 -2.1 -0.1 -0.2 -1.8 -1.3
Coronary Artery Disease (CAD) 0.4 0.5 4.6 0.5 0.2 0.4 -0.4 -2.1 -0.2 -0.6 -0.3 -0.4 -0.7 -0.3 0.5 0.8 0.2 0.8 0.8 -0.1 0.2
Crohns Disease (2012) 1.7 2.8 9.4 1.2 -3.0 -3.1 1.2 1.6 -2.5 -1.6 -2.4 -0.5 -1.1 -1.2 1.6 1.2 -0.8 1.2 1.2 -1.1 -0.2
Mean Putamen Volume 0.8 0.9 2.0 -1.3 0.3 0.5 -0.8 0.9 0.4 1.2 1.2 0.8 0.4 0.8 -1.4 -1.1 -0.5 -1.1 -1.2 -1.0 -1.3
Fasting Glucose 1.3 1.5 3.4 -1.4 0.4 -0.1 -0.6 1.4 -0.4 1.8 1.2 1.5 0.5 1.2 -1.8 -1.2 -1.0 -1.2 -1.4 -1.5 -1.5
HbA1C 0.4 0.5 1.2 1.1 -0.1 -0.1 0.8 -0.9 0.3 -0.9 -0.9 0.1 -0.4 -0.2 1.0 0.8 0.4 0.8 0.9 0.6 0.7
HDL Cholesterol 0.3 0.5 1.5 -0.8 0.2 0.7 -1.0 -0.5 0.6 0.8 0.7 -0.3 0.6 0.4 -0.6 -1.2 -0.5 -1.2 -1.1 -0.3 -0.6
LDL Cholesterol 0.7 1.1 2.8 1.4 -0.9 -0.8 0.7 -1.1 -0.5 -1.3 -1.7 0.5 -0.3 -1.0 1.6 1.4 -0.1 1.4 1.4 0.5 0.8
Lupus 1.1 1.7 7.6 0.0 2.5 2.8 0.2 -2.0 1.7 -0.0 1.1 0.8 1.9 1.9 -0.7 0.5 0.1 0.5 0.4 0.5 0.1
Neuroticism (2016) 0.2 0.3 0.9 0.4 -0.7 -0.4 0.6 -0.1 -0.7 -0.3 -0.5 0.3 0.4 -0.0 0.6 0.9 0.4 0.9 0.8 0.6 0.6
Primary Biliary Cirrhosis 0.1 0.1 0.6 0.2 0.0 -0.2 0.3 0.3 -0.4 -0.3 -0.3 -0.3 0.2 -0.8 -0.0 0.4 -0.3 0.4 0.4 -0.7 -0.3
Rheumatoid Arthritis 9.7 13.4 123.2 -0.0 5.5 6.2 -2.4 -11.1 4.7 -0.1 2.2 -0.0 2.2 2.1 -1.3 0.7 -1.1 0.7 0.7 -1.4 -1.1
Schizophrenia (2014) 0.3 0.7 2.6 -1.0 0.5 0.9 -0.6 -1.1 0.1 1.1 1.0 -0.3 0.8 1.6 -0.9 -0.6 -0.9 -0.6 -0.7 -0.3 -0.7
Triglycerides 0.7 1.2 3.8 1.0 0.6 0.4 1.8 0.7 0.3 -0.6 -0.6 0.4 1.9 0.5 0.7 1.4 0.9 1.4 1.3 1.6 1.4
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.9 0.3 -1.1 -0.7 0.1 0.1 -1.4 -1.0 -0.7 -0.0 -0.2 -0.4 -0.1 -0.0 -0.5 -0.0 0.1 -1.2 -0.7
Ulcerative Colitis 1.3 1.8 4.6 1.6 -1.4 -0.9 0.2 -1.5 -1.4 -1.9 -2.1 -2.0 -0.7 -2.1 1.9 0.5 -0.9 0.5 0.8 -0.3 0.5
Blood Eosinophil Count 0.7 5.5 14.7 -3.3 1.0 0.9 -1.9 3.8 0.4 3.5 3.0 0.9 -1.3 0.6 -3.1 -2.9 -1.3 -2.9 -3.1 -1.8 -2.1
Blood Platelet Count 0.8 9.5 24.5 3.1 3.0 3.0 3.6 1.3 3.3 -2.6 -1.6 2.8 5.0 2.4 2.6 1.6 4.9 1.6 2.0 3.9 4.0
Blood Red Count 0.4 4.1 8.0 2.8 -0.8 -1.4 2.3 -1.8 -2.0 -2.8 -2.7 -0.1 -0.5 -1.8 2.5 2.6 1.1 2.6 2.8 0.4 1.4
Blood White Count 1.0 7.6 63.5 -1.6 0.6 -0.4 0.4 8.0 1.1 2.6 1.3 2.8 0.7 2.0 -1.3 -3.8 2.1 -3.8 -3.5 0.6 -0.2
Heel T-Score 0.6 4.5 13.0 -2.3 2.7 3.5 -0.8 -1.6 2.8 2.3 3.6 0.6 -0.4 3.6 -2.3 -0.9 1.1 -0.9 -1.3 2.0 -0.3
BMI 0.2 1.3 2.9 -1.5 -0.8 -0.2 -1.7 -1.7 -0.5 1.7 0.9 -0.1 -0.2 -0.2 -0.9 -1.2 -1.5 -1.2 -1.2 -0.9 -1.5
Height 0.0 0.7 7.3 0.0 0.1 0.7 -0.5 2.7 0.4 0.3 0.1 0.1 -0.3 -0.9 -0.0 -0.8 -0.2 -0.8 -0.7 0.7 0.3
Waist Hip Ratio (WHR) 0.4 1.9 5.3 -0.9 -2.1 -1.9 -0.9 -0.2 -2.3 0.2 -0.1 -1.8 -0.4 -0.1 -0.8 -0.7 -2.2 -0.7 -0.7 -2.0 -2.0
Systolic Blood Pressure 1.1 5.5 11.3 3.1 -0.8 -1.8 3.3 -1.0 -1.4 -3.3 -3.1 1.8 1.2 0.1 2.7 3.3 1.5 3.3 3.4 0.8 1.9
Smoking Status 2.3 5.6 13.5 -2.9 0.6 0.4 -2.4 3.0 1.1 3.0 2.2 -1.2 -1.3 0.3 -2.4 -3.7 -2.0 -3.7 -3.7 -1.9 -1.9
Allergy or Eczema 1.4 3.7 8.9 2.4 -1.6 -1.8 3.0 2.5 -1.2 -2.2 -2.3 0.9 -0.9 0.7 1.9 1.9 2.0 1.9 2.0 2.0 2.0
Cardiovascular Disease 0.6 2.0 10.2 1.2 0.6 0.6 1.8 -1.0 1.1 -1.0 -0.9 1.7 3.2 0.2 1.1 1.8 1.1 1.8 1.7 1.3 1.3
Hypothyroidism (self reported) 11.3 26.0 163.8 -1.6 8.8 9.2 -4.4 -12.8 6.5 1.6 5.3 -1.0 4.0 3.0 -3.6 -0.7 -1.0 -0.7 -0.7 -1.4 -1.9
Respiratory disease 0.2 0.5 1.3 1.1 0.6 0.9 0.4 -1.0 0.3 -1.1 -0.8 -0.2 0.8 -0.4 0.9 0.1 0.5 0.1 0.4 0.5 1.0
Type 2 Diabetes (T2D) (2018) 1.3 2.5 7.0 2.0 0.1 0.7 1.5 -1.9 0.8 -1.7 -1.7 0.4 2.6 -0.7 1.6 2.2 0.2 2.2 2.3 1.0 1.4
Lung FEV1/FVC ratio 1.1 5.8 13.5 -3.1 0.7 1.3 -2.1 1.3 0.4 3.3 2.8 -0.2 -0.9 2.2 -3.0 -3.6 -1.2 -3.6 -3.7 -1.8 -2.7
Lung FVC 0.5 2.8 17.2 2.0 0.4 0.0 1.0 -4.1 0.4 -2.1 -1.6 -0.8 0.4 -0.7 1.8 2.1 1.4 2.1 2.2 0.1 1.2
Neuroticism 0.8 1.9 6.3 1.2 -1.6 -1.2 0.6 -0.0 -0.7 -2.0 -1.8 -0.4 0.8 -2.5 1.9 1.5 -0.3 1.5 1.5 0.6 1.4
Chronotype (morning person) 1.2 2.8 9.9 1.6 -0.1 -0.6 1.8 -0.6 -0.3 -1.6 -1.6 2.2 1.5 -1.2 1.3 3.1 0.4 3.1 2.9 0.1 0.7
Hair Pigment 0.1 1.5 3.2 1.4 0.9 1.1 1.3 -0.3 1.4 -1.1 -0.9 1.8 1.5 -0.2 1.2 1.3 1.1 1.3 1.4 1.2 1.4
Tanning 0.3 4.1 10.5 -2.6 -0.6 -0.6 -1.9 3.2 -0.7 2.3 2.0 -1.0 -1.7 -0.6 -2.6 -2.3 -2.2 -2.3 -2.5 -1.9 -2.5
Hand grip strength (left) 1.5 3.9 8.1 -2.5 -0.9 -1.3 -2.4 1.0 -0.9 2.4 1.4 -1.8 -2.0 -0.7 -2.0 -2.1 -2.9 -2.1 -2.2 -2.6 -2.4
Number of treatments/medications taken 1.2 2.2 14.4 0.4 1.6 2.4 -0.8 -2.2 2.6 0.0 0.1 1.5 3.8 -0.3 0.2 -0.3 -0.0 -0.3 -0.1 0.6 0.4
Average weekly spirits intake 0.5 0.6 3.9 -0.5 -0.9 0.4 -0.4 2.0 -0.4 0.2 -0.1 -0.7 0.7 -0.7 -0.2 -0.6 -1.6 -0.6 -0.6 -0.1 0.0
Sensitivity / hurt feelings 0.4 0.7 4.8 -0.3 -1.2 -0.4 -0.6 1.6 -1.2 -0.0 -0.2 -0.2 -0.1 -2.2 0.2 -0.6 -0.2 -0.6 -0.5 0.0 -0.0
Frequency of depressed mood in last 2 weeks 0.6 0.9 6.1 0.2 1.2 1.7 -0.0 1.0 0.9 0.0 0.1 1.1 2.5 -0.7 0.1 -0.4 0.5 -0.4 -0.3 0.7 0.6
Hearing difficulty/problems: Yes 0.5 0.8 2.4 -1.0 -0.5 -0.4 -1.0 0.5 -0.7 0.8 0.6 -1.3 -0.9 -1.5 -0.8 -0.9 -0.6 -0.9 -0.9 -1.0 -1.0
Relative age of first facial hair 0.4 0.8 3.9 0.6 -0.2 -0.1 1.3 2.0 -0.2 -0.4 -0.6 0.4 0.4 0.3 0.7 0.8 1.0 0.8 0.7 1.3 1.4
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 7.1 -0.7 -0.1 -0.2 -2.0 -2.7 -0.6 0.5 0.6 -1.1 -0.3 -2.3 -1.1 -1.3 -2.0 -1.3 -1.1 -2.2 -2.1
Ever used hormone-replacement therapy (HRT) 0.4 0.4 0.9 0.9 -0.4 -0.4 0.7 0.9 -0.9 -0.8 -0.9 0.3 -1.0 -0.5 0.8 0.3 0.7 0.3 0.5 0.2 0.7
Ever had hysterectomy (womb removed) 0.8 0.9 4.8 0.2 -1.0 -1.2 -0.3 0.5 -1.4 0.2 -0.6 -1.5 -1.7 -2.2 0.3 -0.3 -0.2 -0.3 -0.2 -0.4 -0.2
Systolic blood pressure, automated reading 0.3 1.0 3.1 0.9 -0.7 -1.6 0.8 0.0 -1.6 -1.1 -1.3 1.8 -0.9 -0.4 0.7 0.7 0.1 0.7 0.8 -1.3 -0.4
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.7 -0.4 0.8 1.3 -0.8 -1.3 1.6 0.3 0.7 -0.7 0.4 -0.1 -0.2 0.1 -0.1 0.1 0.0 0.7 0.2
Angina 0.6 0.8 3.1 -1.0 0.0 0.5 -1.3 -1.8 -0.1 0.9 0.9 -1.6 -0.0 -0.4 -0.9 -0.3 -1.2 -0.3 -0.4 -0.8 -1.0
Medication for hormone replacement therapy 0.4 0.4 2.2 -0.1 0.8 0.7 0.4 1.4 0.3 0.1 0.6 0.1 1.5 0.9 -0.5 -0.2 0.9 -0.2 -0.2 0.4 -0.1
Vitamin and mineral supplements 0.5 0.7 2.1 -0.0 1.2 0.7 0.4 -0.6 1.4 0.0 0.2 0.6 -0.1 -1.1 0.4 1.3 0.2 1.3 1.1 1.1 1.1
Supplements: Zinc 0.3 0.3 1.5 0.2 0.6 0.3 0.2 0.6 0.8 -0.0 -0.1 0.1 1.2 1.1 -0.2 -0.6 -0.1 -0.6 -0.5 -0.6 -0.1
Medication: Co-codamol 0.9 1.0 2.6 -1.2 -0.2 -0.1 -1.5 0.4 -0.5 1.3 1.0 -0.0 -0.5 0.1 -1.0 -1.6 -0.3 -1.6 -1.5 -0.6 -1.3
Medication: Metformin 0.8 1.2 4.8 0.8 0.9 1.8 0.3 -1.7 1.5 -0.5 -0.2 0.9 2.2 0.1 0.7 0.7 0.7 0.7 0.8 1.3 0.9
Diabetes (father) 0.2 0.3 2.4 0.7 -0.0 -0.0 0.2 -0.2 0.5 -0.4 -0.5 -0.7 1.6 -0.3 0.4 0.1 0.6 0.1 0.3 0.4 0.3
Diabetes (mother) 1.3 1.7 5.3 0.8 -2.3 -2.1 0.5 1.0 -2.3 -1.2 -1.7 -0.6 0.4 -2.1 1.3 0.8 -0.7 0.8 0.8 0.0 0.5
Severe depression (siblings) 0.9 1.0 2.2 -0.7 -1.0 -1.0 -1.5 -1.1 -0.9 0.2 0.1 -0.9 -1.2 -0.3 -0.4 -1.2 -1.5 -1.2 -1.0 -1.4 -1.1
Pack years adult smoking proportion 0.1 0.2 1.7 0.2 0.5 0.3 0.2 -0.2 0.5 0.2 0.0 1.3 0.2 -0.4 0.0 -0.4 0.9 -0.4 -0.3 0.3 0.0
Impedance of leg (right) 0.2 1.0 6.9 0.1 0.5 0.6 0.7 2.6 0.7 0.1 0.1 1.1 1.9 0.8 -0.2 -0.9 1.3 -0.9 -0.8 0.7 0.5
Leg fat-free mass (left) 0.2 1.3 3.3 -1.6 0.5 0.7 -1.5 -0.4 0.2 1.8 1.7 -0.8 -1.4 0.8 -1.3 -1.1 -1.1 -1.1 -1.2 -0.5 -1.1
Trunk fat percentage 0.6 2.4 5.9 -1.9 1.3 1.6 -1.4 0.3 1.3 2.4 2.1 1.1 0.9 1.1 -1.4 -2.2 -0.2 -2.2 -2.2 0.9 -0.3
Hand grip strength (right) 0.4 1.0 2.3 -1.1 -0.2 -0.2 -1.5 -0.3 -0.4 1.3 0.8 -1.1 -0.8 -0.6 -0.9 -1.0 -1.5 -1.0 -1.1 -1.2 -1.2
Townsend deprivation index at recruitment 1.7 2.3 6.4 1.9 -0.7 -0.6 2.0 0.4 -0.4 -1.5 -2.0 0.1 0.4 -0.8 2.3 1.5 1.1 1.5 1.6 2.5 2.5
Current tobacco smoking 2.5 4.1 11.2 -2.5 0.5 -0.3 -2.0 3.3 0.8 2.9 1.9 -0.2 -0.0 0.4 -2.1 -3.1 -1.4 -3.1 -3.1 -1.3 -1.7
Average weekly fortified wine intake 0.5 0.6 6.7 -0.4 -0.8 -0.8 0.1 2.6 -0.7 0.2 0.1 0.3 -0.8 0.2 -0.5 -0.3 -0.0 -0.3 -0.4 -0.3 -0.5
Maternal smoking around birth 0.9 1.3 5.3 0.0 -2.3 -1.7 -0.4 0.9 -2.2 0.2 -1.0 -0.8 -0.7 -1.9 0.7 -0.5 -1.5 -0.5 -0.4 -0.2 -0.3
Fed-up feelings 0.5 0.9 6.2 0.9 -0.4 0.7 0.6 0.8 -0.3 -0.7 -1.0 1.1 2.5 -1.2 1.0 0.5 -0.5 0.5 0.6 0.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 8.4 1.0 -1.0 -0.4 0.1 0.7 -1.2 -0.7 -1.4 -0.6 1.9 -2.9 1.4 0.3 -0.1 0.3 0.5 0.7 0.9
Relative age voice broke 0.2 0.3 1.6 -0.2 -0.4 -0.6 0.3 1.3 -0.4 0.1 -0.1 0.2 -0.2 -0.4 0.2 0.6 -0.9 0.6 0.4 0.6 0.7
Taking other prescription medications 1.7 2.7 13.8 -0.1 2.6 3.7 -0.8 -3.1 2.4 0.5 1.2 1.3 2.7 -0.4 -0.7 0.0 0.4 0.0 0.0 0.4 -0.1
Age when periods started (menarche) 0.5 1.3 9.1 0.5 -0.8 -0.8 1.1 3.0 -0.1 -0.0 -0.6 2.7 0.1 -0.7 0.4 0.0 1.4 0.0 0.1 0.4 0.5
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 6.0 2.3 -1.6 -0.9 1.8 -0.6 -1.1 -2.3 -2.3 -0.7 1.0 -1.7 2.5 2.0 1.5 2.0 2.2 1.4 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 2.7 -0.9 0.9 1.2 -0.3 0.7 1.2 1.1 1.4 0.8 0.9 1.6 -0.9 -1.0 0.6 -1.0 -1.1 1.1 0.1
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 4.1 -1.0 -0.5 -0.6 -1.5 -0.5 -0.8 0.8 0.7 -0.2 -0.1 -0.6 -1.3 -0.8 -1.5 -0.8 -0.8 -1.7 -2.0
Qualifications: CSEs or equivalent 1.0 1.3 3.7 1.3 -0.7 -0.8 0.3 -1.5 -0.2 -1.9 -1.1 -0.8 -0.9 -1.9 1.3 1.3 0.4 1.3 1.3 0.7 1.2
Serious illness, injury or assault to yourself 1.4 1.7 7.5 0.5 -1.3 1.1 -0.1 -1.9 0.4 -0.7 -1.2 0.1 2.7 -2.1 1.3 1.3 -1.7 1.3 1.2 0.7 0.8
High blood pressure 1.3 3.6 11.4 1.8 1.3 1.2 2.5 1.2 1.7 -1.4 -1.1 3.1 3.4 0.9 1.3 1.6 2.3 1.6 1.7 2.0 2.0
Hayfever, allergic rhinitis or eczema 1.1 2.3 7.0 1.6 -0.7 -1.1 2.6 2.6 -0.7 -1.5 -1.4 0.9 -1.0 1.3 1.1 1.2 2.0 1.2 1.3 1.6 1.5
Multivitamins +/- minerals 0.6 0.7 2.7 -0.5 0.4 1.2 -0.2 0.9 -0.3 0.5 0.7 -0.3 1.0 1.6 -0.9 -1.2 0.0 -1.2 -1.1 -0.8 -0.9
Stomach or abdominal pain in last month 0.3 0.4 2.6 -0.2 -0.7 -0.6 -0.5 -1.6 -0.1 0.3 -0.2 -0.3 0.5 -0.4 0.2 0.0 -1.4 0.0 -0.0 0.0 0.1
Supplements: Glucosamine 0.6 0.8 5.0 0.6 -1.0 -1.2 0.5 2.2 -1.0 -0.8 -1.0 1.7 0.2 -0.1 0.6 -0.5 -0.3 -0.5 -0.3 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.9 0.7 -0.6 -0.9 0.3 -0.1 -0.0 -1.0 -0.8 0.2 -0.1 -1.7 0.6 0.7 -0.0 0.7 0.8 0.1 0.3
Medication: Atenolol 0.1 0.2 1.0 -0.1 0.4 0.5 -0.3 0.3 0.0 0.1 0.1 0.5 0.6 -1.0 -0.2 -0.3 -0.1 -0.3 -0.3 -0.5 -0.4
Medication: Levothyroxine sodium 7.8 13.2 73.1 -1.3 6.6 7.2 -3.0 -8.6 4.9 1.4 4.0 -1.1 1.9 1.6 -2.5 -0.4 -0.0 -0.4 -0.5 -0.3 -0.9
Sitting height 0.0 0.3 1.3 -0.0 -0.4 -0.1 -0.0 0.1 -0.0 0.0 0.0 -0.4 -0.4 -0.4 -0.2 1.0 -1.1 1.0 0.8 -0.2 -0.4
Chronic bronchitis/emphysema (father) 1.4 1.6 7.1 -0.8 -1.7 -2.7 -1.1 1.2 -0.8 0.5 -0.3 -0.9 -0.6 -2.2 -0.1 -0.8 -2.3 -0.8 -0.8 -0.9 -0.7
High blood pressure (mother) 0.5 0.7 2.0 -0.6 -0.5 -0.0 -0.3 0.7 -1.4 0.7 0.3 0.2 0.8 -0.2 -0.9 -0.6 -1.3 -0.6 -0.7 -1.3 -1.3
Body mass index (BMI) 0.5 2.0 5.6 -2.0 1.2 1.0 -1.8 -0.6 0.9 2.4 2.1 0.4 -0.3 1.0 -1.5 -1.7 -0.8 -1.7 -1.9 -0.1 -0.9
Impedance of leg (left) 0.2 0.9 5.9 0.4 0.1 0.4 0.9 2.4 0.4 -0.2 -0.3 0.8 2.2 0.2 0.3 -0.5 1.1 -0.5 -0.4 1.1 0.9
Leg predicted mass (left) 0.2 1.2 3.2 -1.5 0.6 0.7 -1.4 -0.5 0.2 1.8 1.6 -0.8 -1.4 0.8 -1.3 -1.0 -1.1 -1.0 -1.1 -0.5 -1.1
Trunk fat mass 0.7 2.9 7.9 -2.3 1.2 1.5 -1.7 0.6 1.3 2.8 2.4 0.9 0.6 1.2 -1.7 -2.4 -0.6 -2.4 -2.4 0.5 -0.7
Waist circumference 0.9 3.4 8.1 -2.7 0.3 0.6 -2.3 0.1 0.3 2.9 2.4 0.0 -0.2 1.3 -2.2 -2.5 -1.7 -2.5 -2.7 -0.8 -1.8
Number of incorrect matches in round 1.0 1.6 7.9 -1.5 0.2 0.6 -2.1 -2.8 -0.7 0.7 1.3 -1.5 -1.0 -0.6 -1.0 -0.8 -1.6 -0.8 -1.0 -1.0 -1.1
Past tobacco smoking 1.3 2.4 8.7 1.7 0.0 0.1 1.6 -3.0 -0.3 -1.7 -1.2 0.8 1.3 0.1 1.4 2.5 1.0 2.5 2.4 1.1 0.9
Alcohol usually taken with meals 1.5 2.4 6.6 1.1 2.2 1.9 1.1 -1.7 2.3 -0.5 0.2 0.8 2.2 1.9 0.2 1.1 2.6 1.1 1.1 1.7 1.3
Nervous feelings 0.6 1.1 6.2 0.6 1.4 1.0 0.4 0.3 1.4 -1.0 -0.1 0.4 2.5 0.2 0.5 0.9 1.1 0.9 0.8 0.9 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 6.1 -0.0 -0.2 0.5 -0.9 -0.9 -0.0 -0.1 -0.2 -0.3 2.5 -1.9 0.2 -0.4 -0.9 -0.4 -0.3 -0.2 -0.1
Hearing difficulty/problems with background noise 1.1 1.7 4.0 -0.9 -1.4 -1.4 -1.1 2.0 -0.9 0.7 0.0 -1.1 -0.7 -1.6 -0.7 -1.7 -1.5 -1.7 -1.6 -1.4 -1.4
Hair/balding pattern: Pattern 2 0.2 0.2 1.3 -0.2 -1.2 -0.2 0.0 0.9 -0.6 0.3 -0.3 -0.1 0.1 -0.2 0.2 -0.4 -0.8 -0.4 -0.3 0.2 -0.1
Had menopause 1.7 2.1 4.7 -1.7 1.2 1.1 -1.6 0.9 0.7 1.5 1.9 0.9 -1.0 1.3 -1.7 -2.2 -0.2 -2.2 -2.1 -0.9 -1.3
Had other major operations 0.9 1.1 4.0 1.5 0.3 -0.2 1.5 0.3 -0.1 -1.7 -1.0 -0.1 1.0 0.4 1.1 1.1 2.0 1.1 1.2 0.8 0.8
Forced vital capacity (FVC) 0.8 3.2 6.1 1.9 -1.9 -1.9 0.3 -2.4 -1.4 -2.2 -2.5 -2.4 -1.1 -2.5 2.2 1.7 -0.5 1.7 1.9 -0.4 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 4.0 -0.2 1.4 2.0 0.2 0.3 1.8 0.2 1.0 0.7 1.5 1.7 -0.3 -0.2 1.1 -0.2 -0.2 1.5 0.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.2 -1.1 -0.1 0.3 -1.6 -0.5 -0.2 1.1 0.8 -0.1 1.3 -0.3 -1.0 -0.8 -1.8 -0.8 -0.9 -1.1 -1.4
Qualifications: None of the above 0.4 0.9 7.9 0.3 -1.1 -0.7 0.3 0.7 -0.7 -0.0 -1.0 1.1 0.5 -2.8 1.1 0.2 -0.9 0.2 0.3 0.6 0.9
Financial difficulties in last 2 years 0.8 1.1 6.0 0.3 -2.1 -1.5 -0.1 -0.2 -2.5 -0.2 -1.3 -0.2 -0.5 -1.4 0.7 -0.3 -1.2 -0.3 -0.1 -1.0 -0.4
Mouth/teeth dental problems 0.8 1.2 3.5 -1.0 1.8 1.2 0.2 1.2 1.1 1.1 1.9 0.5 0.4 1.8 -1.6 -0.4 1.1 -0.4 -0.6 0.4 -0.4
Heart attack 0.7 1.0 6.1 -0.1 1.2 1.5 -0.3 -2.5 1.9 0.1 0.4 -0.6 1.3 0.2 -0.0 0.2 -0.2 0.2 0.2 0.8 0.7
Allergy 1.2 2.8 7.1 -2.1 -0.3 0.1 -2.6 -1.7 -0.4 1.8 1.4 -1.2 -0.1 -0.8 -1.5 -1.5 -2.7 -1.5 -1.6 -2.3 -2.3
Pain all over the body in last month 2.4 2.5 6.1 2.4 0.7 0.3 1.8 -0.4 1.5 -2.0 -1.9 1.1 2.5 -0.4 2.0 1.2 1.7 1.2 1.5 1.7 1.9
Diabetes (self-reported) 1.7 2.6 8.8 1.8 1.1 1.9 1.2 -2.7 1.6 -1.2 -0.9 0.6 3.0 0.6 1.1 1.8 1.3 1.8 1.9 1.4 1.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 4.8 0.3 -0.7 -1.4 1.0 2.2 -1.3 -0.5 -0.3 -0.6 -1.0 0.6 -0.1 0.3 0.7 0.3 0.3 0.4 0.3
Medication: Ramipril 2.9 3.7 8.6 2.3 0.3 0.5 2.1 -0.3 1.0 -2.1 -1.8 0.6 2.9 1.0 2.1 2.2 1.8 2.2 2.3 2.8 2.7
Medication: Simvastatin 1.2 1.8 3.8 1.4 -0.5 0.1 1.4 0.2 0.4 -1.3 -1.4 0.8 1.9 -1.0 1.5 1.7 1.6 1.7 1.7 1.6 1.7
Fluid intelligence score 0.5 1.0 3.7 1.2 -0.9 -1.1 0.2 -0.7 -0.6 -1.4 -1.4 -1.9 -1.1 -1.6 1.3 0.5 -0.3 0.5 0.7 -0.2 0.4
Illnesses of siblings 1.3 1.8 5.9 -1.2 -1.3 -1.0 -1.4 -1.5 -1.3 1.0 0.8 -2.1 -2.4 -0.4 -1.0 -0.7 -1.5 -0.7 -0.8 -1.8 -1.8
Neuroticism score 0.4 0.8 5.2 0.7 -0.2 0.2 0.3 0.5 0.1 -1.2 -0.7 0.2 2.3 -1.3 0.9 0.8 0.5 0.8 0.8 0.8 1.0
Weight 0.4 2.0 6.0 -2.1 0.7 0.9 -1.9 0.2 0.6 2.5 2.1 0.0 -0.4 0.8 -1.6 -1.8 -1.1 -1.8 -1.9 -0.2 -1.1
Impedance of arm (right) 0.0 0.2 0.5 0.6 -0.4 -0.2 0.4 0.4 -0.3 -0.7 -0.6 -0.6 0.5 -0.5 0.5 -0.3 0.6 -0.3 -0.1 0.5 0.7
Arm fat percentage (right) 0.7 2.6 6.8 -2.3 1.1 1.1 -2.0 -0.2 1.1 2.6 2.4 0.1 0.1 1.2 -1.7 -2.3 -0.8 -2.3 -2.4 0.1 -0.8
Trunk fat-free mass 0.3 1.7 4.2 -1.8 0.4 0.4 -1.5 1.0 0.4 2.0 1.7 -0.3 -1.2 0.7 -1.7 -1.2 -1.2 -1.2 -1.4 -1.1 -1.7
Hip circumference 0.8 3.5 9.5 -2.7 1.3 1.6 -2.1 0.5 1.5 3.1 2.8 0.0 -0.5 1.4 -2.0 -2.6 -0.8 -2.6 -2.7 0.2 -0.9
Time employed in main current job 0.4 0.5 1.5 0.3 -0.8 -1.1 -0.5 0.5 -0.0 -0.3 -0.6 -1.2 -0.7 -1.2 0.5 -0.9 0.2 -0.9 -0.6 -0.3 -0.1
Alcohol intake versus 10 years previously 0.5 0.7 3.3 -0.9 0.0 0.1 -0.9 -0.6 -0.6 1.1 0.7 -0.5 -0.1 0.3 -0.9 -0.7 -1.8 -0.7 -0.7 -1.2 -1.2
Father’s age at death 0.4 0.5 4.1 -0.5 -0.3 -0.3 0.3 2.0 0.1 0.6 0.2 -0.1 -1.9 -0.0 -0.5 -0.4 -0.0 -0.4 -0.5 -0.3 -0.2
Worrier / anxious feelings 0.5 0.9 2.8 1.0 0.3 0.6 0.9 -0.2 0.5 -1.2 -0.4 1.0 1.7 1.3 0.9 0.5 1.7 0.5 0.7 1.2 1.0
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 9.6 1.9 -0.1 0.7 0.7 -1.2 0.5 -1.6 -1.9 0.5 3.1 -3.1 2.2 2.0 -0.2 2.0 2.0 1.1 1.6
Falls in the last year 0.2 0.3 3.0 0.1 0.2 -0.1 -0.3 0.1 0.8 -0.3 -0.2 -0.1 0.8 -1.7 0.5 -0.4 0.2 -0.4 -0.2 0.2 0.4
Hair/balding pattern: Pattern 3 0.8 1.2 4.0 -0.1 -1.6 -1.7 0.0 -0.5 -1.7 -0.3 -0.7 -0.6 -2.0 -0.5 0.1 0.8 -1.7 0.8 0.6 -1.4 -0.7
Number of live births 1.0 1.4 4.5 1.2 -0.1 -0.4 1.7 1.5 0.0 -0.9 -0.8 0.4 -0.1 0.2 1.2 1.1 2.1 1.1 1.2 2.0 2.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 5.4 1.5 -1.7 -1.4 0.3 -2.3 -1.3 -1.7 -1.9 -2.3 -1.0 -1.5 1.9 1.3 -0.3 1.3 1.4 -0.2 0.6
Pulse rate 0.1 0.1 0.5 0.0 -0.3 -0.5 0.2 0.5 -0.2 0.1 -0.1 0.7 -0.0 -0.5 -0.0 0.3 -0.4 0.3 0.2 -0.1 -0.4
Happiness 0.6 0.7 2.0 -1.2 1.1 0.2 -1.2 0.1 1.4 1.0 1.4 -0.7 0.1 -0.4 -0.9 -0.7 0.2 -0.7 -0.8 -0.1 -0.3
Noisy workplace 0.6 0.7 2.8 -0.3 -1.5 -1.7 -0.2 -0.8 -1.6 0.1 -0.5 -0.0 -0.0 -1.6 0.2 0.4 -0.9 0.4 0.3 -0.4 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.7 4.6 -0.4 0.7 0.2 -0.4 -0.3 0.5 0.6 0.7 -1.4 -1.0 2.1 -0.9 -0.5 0.3 -0.5 -0.5 -0.6 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.0 0.4 -0.9 -0.4 0.2 1.0 -0.6 -0.6 -0.6 0.3 0.5 -0.8 0.5 0.7 -0.1 0.7 0.7 0.5 0.4
Mouth/teeth dental problems: Dentures 0.8 1.3 3.5 -0.8 -0.6 -0.8 -1.6 -0.5 -0.7 0.7 0.1 -1.4 -1.9 -1.3 -0.6 -1.1 -1.7 -1.1 -1.1 -1.6 -1.1
Asthma 0.2 0.4 1.6 0.9 1.1 1.0 0.7 -1.3 0.4 -0.7 -0.2 0.4 0.3 0.4 0.4 0.5 0.5 0.5 0.6 0.2 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.3 -0.5 0.2 0.1 -0.9 -0.5 1.1 0.9 0.3 0.3 0.4 0.3 -0.3 -0.6 -1.1 -0.6 -0.6 -0.6 -0.3
Medication: Cholesterol lowering 0.9 1.4 7.3 0.4 1.6 1.4 0.6 -1.7 2.2 0.0 -0.0 1.0 2.7 0.1 0.2 0.8 0.9 0.8 0.8 0.6 0.7
Depression (self-reported) 2.6 3.1 7.1 -2.0 1.1 0.5 -2.2 0.3 0.6 2.3 2.0 0.1 0.4 0.4 -2.2 -2.7 -0.8 -2.7 -2.6 -2.0 -2.3
Medication: Lansoprazole 0.3 0.3 1.2 0.4 0.4 0.6 0.3 -0.3 0.4 -0.5 -0.2 0.7 1.1 -0.2 0.4 0.8 -0.1 0.8 0.8 0.6 0.7
Prospective memory result 0.6 0.7 2.4 -1.3 0.7 0.6 -0.6 0.2 -0.0 1.6 1.4 -0.4 0.0 0.3 -1.2 -0.9 -0.2 -0.9 -1.0 -0.3 -0.7
Lung cancer (father) 0.9 1.0 6.6 0.3 -1.8 -1.1 0.2 1.7 -2.6 -0.2 -1.0 0.4 -0.4 -1.3 0.5 0.0 -0.9 0.0 0.1 -0.5 -0.4
Illnesses of mother 3.8 4.7 10.7 3.1 -0.2 -0.8 2.1 -2.1 0.2 -3.0 -2.6 -0.2 -0.1 -0.3 3.3 2.5 2.3 2.5 2.8 2.2 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 5.0 1.4 -0.9 -0.9 0.4 -2.2 -0.2 -1.3 -1.5 -2.2 -0.5 -1.1 1.5 0.9 0.3 0.9 1.1 -0.1 0.6
Pulse wave Arterial Stiffness index 0.9 1.1 5.2 0.4 -1.6 -1.6 0.6 2.3 -1.6 -0.5 -1.1 0.5 -1.7 -0.5 0.6 -0.5 0.1 -0.5 -0.3 -0.5 -0.2
Impedance of arm (left) 0.2 0.9 2.2 1.4 -0.4 0.1 1.3 0.1 0.0 -1.4 -1.2 -0.1 0.9 -0.3 1.3 0.5 1.3 0.5 0.8 1.4 1.5
Arm fat mass (right) 0.6 2.3 6.7 -2.3 0.8 0.8 -1.9 0.1 0.8 2.6 2.3 0.1 -0.2 1.0 -1.7 -2.0 -0.9 -2.0 -2.1 -0.1 -1.0
Trunk predicted mass 0.3 1.5 3.9 -1.7 0.4 0.4 -1.4 1.0 0.4 2.0 1.7 -0.2 -1.3 0.6 -1.7 -1.2 -1.2 -1.2 -1.3 -1.1 -1.6
Standing height 0.1 0.5 3.8 -0.5 -0.8 -0.4 -0.5 1.9 -0.5 0.7 0.4 -0.7 -0.8 -0.4 -0.6 -0.6 -0.7 -0.6 -0.6 -0.3 -0.7
Length of working week for main job 0.5 0.6 3.2 0.4 -0.5 -0.3 0.6 1.5 0.9 -0.4 -0.8 -0.9 -0.2 -1.8 0.8 0.4 -0.2 0.4 0.4 0.4 1.0
Exposure to tobacco smoke at home 0.5 0.5 1.8 0.1 -1.3 -0.9 -0.5 0.7 -0.4 0.1 -0.5 -0.8 -1.3 0.4 0.2 -1.0 -0.7 -1.0 -0.8 -0.2 -0.3
Breastfed as a baby 0.5 0.7 3.6 -0.5 0.7 0.7 -0.7 1.1 0.7 0.5 0.8 1.0 -1.9 1.1 -0.5 -0.7 0.5 -0.7 -0.7 0.2 0.0
Tense / ‘highly strung’ 2.4 4.0 16.1 2.0 1.4 1.1 1.9 -0.3 1.4 -1.8 -1.1 1.8 4.0 1.0 1.7 2.1 2.5 2.1 2.1 2.6 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.4 -1.2 -0.4 -0.6 -1.9 0.1 -0.9 0.8 0.9 -1.6 -0.2 0.1 -1.1 -1.6 -0.6 -1.6 -1.5 -0.9 -1.2
Hair/balding pattern: Pattern 4 0.2 0.5 2.6 0.3 0.7 0.9 0.5 -0.3 0.6 -0.3 0.1 1.6 1.4 -0.4 0.1 0.4 1.0 0.4 0.4 0.8 0.6
Birth weight of first child 0.4 0.8 5.7 -0.2 -1.0 -1.5 0.0 2.4 -0.1 0.2 -0.0 -0.3 -1.3 -0.5 -0.3 -0.7 0.0 -0.7 -0.7 -0.6 -0.7
Peak expiratory flow (PEF) 0.3 0.7 7.1 -0.2 -0.2 -0.6 -0.7 -0.9 -0.6 0.4 0.3 -2.7 -1.5 0.1 -0.2 -0.6 0.5 -0.6 -0.5 -0.5 -0.4
Pulse wave reflection index 0.5 0.6 3.7 -0.3 -1.0 -1.0 0.1 1.9 -1.1 0.0 -0.2 0.0 -1.2 -0.2 -0.1 -0.7 -0.3 -0.7 -0.6 -0.6 -0.4
Ever highly irritable/argumentative for 2 days 2.3 2.8 7.8 1.9 0.3 0.5 1.8 -0.1 0.4 -1.8 -1.6 1.2 2.8 -0.6 1.8 2.4 1.1 2.4 2.3 1.6 2.0
Loud music exposure frequency 0.2 0.2 1.6 0.1 -0.4 -0.1 -0.1 -0.2 0.1 0.1 -0.5 0.5 1.0 -0.2 0.0 0.2 -1.2 0.2 0.2 -0.8 -0.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.3 -0.6 -0.3 -1.0 -0.7 -0.1 0.2 0.1 0.5 -1.3 -1.5 1.1 -0.6 -0.3 0.2 -0.3 -0.4 -0.4 -0.7
Mouth/teeth dental problems: Bleeding gums 4.9 6.3 11.6 3.3 0.2 0.9 2.6 -1.2 1.0 -2.9 -2.8 1.6 3.4 0.4 3.4 2.8 2.2 2.8 3.0 3.1 3.4
Blood clot in the leg (DVT) 1.5 1.9 6.1 1.1 1.4 1.3 1.4 1.0 1.0 -0.9 -0.3 1.7 2.5 0.3 0.8 1.1 2.1 1.1 1.1 1.9 1.7
Medication: Paracetamol 1.0 1.7 5.8 -1.2 0.8 0.8 -1.8 -1.0 1.0 1.5 1.1 -0.2 1.3 0.3 -0.8 -2.4 -0.8 -2.4 -2.2 -0.0 -0.2
Headache pain in last month 0.2 0.4 3.1 -0.1 -0.3 0.6 -0.5 -1.8 0.1 0.3 -0.2 -0.6 1.0 -0.0 -0.1 0.1 -1.2 0.1 0.1 -0.6 -0.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 11.0 -0.3 -1.1 -1.5 -0.6 1.1 -2.1 -0.1 0.1 -0.8 -3.3 0.2 -0.1 -1.3 0.1 -1.3 -1.1 -0.5 -0.5
Glaucoma (self-reported) 0.7 0.8 2.4 0.9 -1.5 -1.3 0.1 0.8 -1.3 -0.8 -1.6 0.3 1.0 -1.3 1.1 -0.1 -0.0 -0.1 0.2 -0.5 0.0
Gout (self-reported) 0.2 0.3 1.3 -0.4 -0.6 -0.4 -0.1 0.6 -0.9 0.3 0.2 -0.5 -1.1 -0.7 -0.5 -0.3 -0.6 -0.3 -0.3 -0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 9.9 19.4 114.5 -1.3 7.9 8.6 -3.3 -10.7 5.6 1.3 4.7 -0.7 3.3 2.9 -3.0 -0.1 -0.2 -0.1 -0.2 -0.4 -1.1
Medication: Amlodipine 0.5 0.7 3.6 1.0 -0.2 -0.7 -0.0 -1.9 0.2 -0.9 -1.0 -1.0 0.7 -1.1 0.8 0.9 -0.2 0.9 0.9 -0.1 0.4
Medication: Ventolin 100micrograms inhaler 1.3 1.7 2.9 1.3 -1.2 -1.7 0.9 -1.5 -1.4 -1.7 -1.6 -0.9 -1.4 -1.7 1.1 1.6 -0.2 1.6 1.6 -0.6 0.2
Birth weight 0.5 1.1 8.8 0.6 -1.0 -1.4 0.4 3.0 -1.3 -0.8 -0.8 -1.6 -0.9 -0.9 0.4 -0.1 0.4 -0.1 0.1 0.2 0.2
Chronic bronchitis/emphysema (mother) 2.3 2.7 13.8 -0.2 2.2 2.0 0.3 1.3 3.5 0.7 0.9 2.1 3.7 0.8 -0.2 -0.2 1.6 -0.2 -0.2 1.5 0.9
High blood pressure (siblings) 1.1 1.6 5.3 -0.1 1.9 1.1 0.5 2.3 1.7 0.3 0.6 2.3 2.3 1.6 -0.4 -0.4 1.1 -0.4 -0.4 0.6 0.6
Forced vital capacity (FVC), Best measure 0.5 1.7 5.4 1.4 -1.0 -1.2 0.2 -2.3 -0.5 -1.4 -1.6 -2.3 -0.6 -1.8 1.5 1.1 -0.1 1.1 1.3 -0.4 0.5
Body fat percentage 0.8 3.2 7.4 -2.2 1.6 1.9 -1.6 0.5 1.7 2.7 2.5 1.3 1.2 1.5 -1.7 -2.5 -0.2 -2.5 -2.5 0.9 -0.4
Leg fat percentage (right) 1.3 4.6 8.7 -2.4 2.2 2.2 -1.8 1.3 2.3 3.0 2.8 1.9 1.5 2.0 -2.0 -2.9 0.0 -2.9 -2.9 0.7 -0.6
Arm fat-free mass (right) 0.2 0.8 2.9 -1.3 0.6 0.7 -0.8 0.7 0.3 1.7 1.4 0.2 -0.6 0.9 -1.2 -0.7 -0.6 -0.7 -0.8 -0.3 -1.0
Exposure to tobacco smoke outside home 0.7 0.9 2.6 1.4 -0.5 -0.9 1.3 0.6 0.1 -1.6 -1.5 -0.1 0.5 -0.7 1.2 1.1 0.2 1.1 1.2 0.2 0.9
Comparative body size at age 10 1.2 3.2 9.4 -1.9 0.1 -0.5 -2.6 -0.5 -0.6 1.3 1.5 -3.1 -1.6 -1.3 -1.6 -2.1 -2.2 -2.1 -2.1 -2.1 -2.1
Number of full brothers 0.7 0.8 6.5 0.5 1.2 0.4 1.0 0.9 0.2 -0.2 -0.2 2.5 -0.1 -0.1 0.5 0.5 1.3 0.5 0.5 1.2 1.0
Worry too long after embarrassment 1.0 1.6 5.3 0.9 -1.5 -1.2 1.6 2.3 -1.1 -1.6 -1.2 0.1 0.6 -0.3 1.3 1.2 1.1 1.2 1.1 1.4 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.2 -0.6 -1.6 -1.8 -1.2 0.8 -1.4 0.2 -0.1 -1.3 -0.1 -0.9 -0.4 -1.2 -1.0 -1.2 -1.1 -1.3 -1.5
Wheeze or whistling in the chest in last year 0.3 0.5 2.3 -0.2 -0.7 -0.2 -0.3 1.5 -0.8 0.3 -0.3 -0.7 -0.2 -0.8 0.1 -0.9 -0.9 -0.9 -0.8 0.1 -0.1
Number of children fathered 0.8 0.9 3.5 -0.8 -0.3 -0.5 -1.2 0.2 -0.7 0.5 0.4 -0.8 -0.3 -1.7 -1.0 -0.8 -1.3 -0.8 -0.8 -1.9 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 4.5 -1.2 -0.0 0.2 -1.8 -1.8 -0.6 0.6 0.8 -1.6 -2.1 -1.1 -0.7 -0.8 -2.1 -0.8 -0.9 -1.7 -1.3
Age at first live birth 0.4 0.8 2.2 0.5 0.2 0.8 0.9 -1.4 0.5 -0.6 -0.2 0.6 1.4 1.3 0.3 1.5 0.3 1.5 1.3 0.2 0.3
Pulse wave peak to peak time 0.6 0.8 5.1 -0.4 1.1 1.2 -0.8 -2.2 1.0 0.4 0.8 -0.8 1.3 0.1 -0.5 0.4 -0.4 0.4 0.3 0.1 -0.1
Health satisfaction 0.7 0.8 4.8 0.6 -0.4 -0.3 -0.4 -1.1 -0.0 -0.6 -0.6 -1.0 1.7 -2.2 0.6 1.1 -0.4 1.1 1.0 0.0 0.1
Shortness of breath walking on level ground 0.2 0.2 2.0 0.4 -0.0 -0.2 -0.4 -1.4 -0.3 -0.1 -0.3 0.0 0.6 -0.6 0.5 -0.0 0.8 -0.0 0.1 0.0 -0.0
Qualifications: College or University degree 0.4 1.2 3.2 1.7 -0.8 -0.1 1.5 -0.9 -0.6 -1.7 -1.4 -0.4 1.0 1.8 0.8 1.1 0.9 1.1 1.3 -0.1 -0.1
Eye problems/disorders: None of the above 0.8 1.0 3.8 0.4 -1.2 -1.7 0.0 -1.1 -1.4 -0.8 -0.8 -0.9 -2.0 -0.3 0.5 0.8 -1.2 0.8 0.8 -0.4 -0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.1 0.2 1.0 1.4 0.4 0.3 1.3 0.1 0.3 1.4 0.8 1.3 -0.3 -0.3 0.9 -0.3 -0.2 0.4 0.0
Emphysema/chronic bronchitis 0.5 0.5 1.4 -0.7 0.7 0.3 -1.2 -0.4 0.9 0.8 0.7 -0.0 -0.2 -1.1 -0.4 -1.0 -0.2 -1.0 -0.9 -0.1 -0.1
Medication for pain relief, constipation, heartburn 0.7 1.3 3.8 0.9 -0.9 -1.1 1.2 0.6 -1.8 -1.2 -0.9 0.1 -2.0 -0.7 0.5 1.6 0.6 1.6 1.5 -0.7 -0.3
Neck or shoulder pain in last month 0.6 0.9 2.9 -0.7 -0.7 -0.2 -1.4 0.4 -1.3 0.9 -0.1 -0.9 0.9 -1.7 -0.3 -1.0 -0.8 -1.0 -0.9 -1.1 -0.8
Medication: Blood pressure 1.0 1.8 10.8 1.1 0.6 1.2 1.2 -0.6 1.6 -0.8 -0.8 0.9 3.3 -0.6 0.9 1.6 0.1 1.6 1.5 1.1 1.4
Angina (self-reported) 0.5 0.7 3.5 -0.6 -0.1 0.3 -1.1 -1.9 -0.4 0.5 0.6 -1.8 -0.0 -0.8 -0.7 0.0 -1.0 0.0 -0.1 -0.9 -0.9
Migraine (self-reported) 2.1 2.6 4.9 -1.6 1.3 1.7 -0.8 1.4 0.9 2.0 1.7 1.7 0.5 2.2 -2.1 -1.8 -0.8 -1.8 -1.9 -1.3 -1.7
Medication: Ibuprofen 0.1 0.2 0.8 -0.2 0.1 0.3 -0.6 -0.8 0.9 0.6 0.0 0.4 0.1 -0.1 -0.1 -0.3 -0.6 -0.3 -0.3 -0.4 -0.0
Medication: Allopurinol 0.8 1.1 3.9 0.1 -2.0 -1.7 0.1 0.1 -1.9 -0.3 -0.9 -1.0 -1.3 -1.6 0.4 0.2 -1.5 0.2 0.2 -0.5 -0.4
Medication: Omeprazole 0.5 0.6 2.5 -0.3 -0.0 0.1 -0.7 -1.1 1.4 0.4 0.1 -1.0 0.6 -1.6 0.4 0.0 -0.1 0.0 -0.0 1.3 0.9
Medication: Seretide 50 evohaler 2.0 2.4 6.0 1.4 2.2 1.8 1.5 0.5 1.7 -1.4 -0.4 1.0 2.5 0.0 1.1 1.3 1.6 1.3 1.4 1.9 2.3
Mean time to correctly identify matches 0.5 0.9 8.9 -0.8 -1.3 -0.6 0.2 3.0 -0.5 -0.1 0.1 0.0 0.4 0.4 -0.5 -0.5 -1.6 -0.5 -0.6 -0.3 -0.5
Heart disease (mother) 0.3 0.4 3.4 0.1 0.3 0.4 -0.2 -0.6 0.1 -0.2 0.1 0.4 1.9 1.4 -0.1 0.4 0.4 0.4 0.4 0.5 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.2 0.2 0.8 -0.1 0.6 0.8 1.1 -0.2 0.1 0.5 0.2 0.3 0.1 0.6 0.5 0.6 0.5 0.7 0.8
Whole body fat mass 0.8 3.3 8.9 -2.4 1.4 1.6 -1.8 0.8 1.4 3.0 2.6 1.0 0.7 1.7 -2.0 -2.4 -0.6 -2.4 -2.5 0.4 -0.8
Leg fat mass (right) 1.0 3.8 9.2 -2.6 1.6 1.6 -2.0 0.9 1.5 3.0 2.8 0.9 0.5 1.8 -2.2 -2.6 -0.6 -2.6 -2.7 0.1 -1.1
Arm predicted mass (right) 0.2 0.8 3.0 -1.4 0.5 0.5 -1.0 0.6 0.2 1.7 1.5 0.0 -0.6 0.9 -1.3 -0.7 -0.6 -0.7 -0.9 -0.4 -1.0
Pulse rate, automated reading 1.0 3.1 9.1 0.6 2.1 1.9 1.1 1.4 3.0 0.1 0.3 2.2 2.8 1.1 0.6 -0.0 2.9 -0.0 0.1 3.0 2.0
Alcohol intake frequency. 0.9 2.0 13.0 -0.7 -0.5 -0.2 -1.8 -3.6 -1.5 0.7 0.3 -1.4 -0.7 -1.9 -0.4 -0.4 -2.2 -0.4 -0.4 -1.6 -1.3
Comparative height size at age 10 1.1 6.1 13.8 -2.5 -1.7 -1.1 -3.1 0.3 -1.8 2.5 1.3 -2.4 -2.0 -2.4 -2.3 -2.5 -3.5 -2.5 -2.5 -3.5 -3.7
Number of full sisters 1.3 1.6 5.8 0.8 -1.2 -0.7 0.2 -1.7 -1.6 -1.0 -1.1 -1.0 -1.7 -2.4 1.1 1.6 -0.2 1.6 1.5 0.2 0.6
Suffer from ‘nerves’ 0.7 1.0 2.0 1.2 -0.7 -1.3 0.9 0.4 -1.1 -1.4 -1.3 -0.4 1.2 -1.2 1.0 1.2 0.6 1.2 1.2 0.2 0.7
Overall health rating 0.7 1.4 10.0 0.9 0.3 0.7 -0.5 -2.0 0.8 -0.7 -0.9 0.9 3.2 -2.2 0.9 0.3 -0.4 0.3 0.5 0.3 0.5
Chest pain or discomfort 1.1 1.6 4.9 -0.6 1.8 2.2 -1.0 -1.4 1.6 1.1 1.1 0.1 2.2 0.1 -0.8 -1.6 -0.1 -1.6 -1.4 -0.3 -0.7
Had major operations 0.8 0.9 1.9 1.4 0.2 0.2 1.2 -0.9 0.5 -1.3 -1.1 0.4 1.0 0.1 0.9 1.3 1.0 1.3 1.4 0.2 0.6
Age at last live birth 1.3 1.9 4.5 1.0 1.0 1.7 1.5 -0.4 1.4 -1.0 -0.3 0.5 2.1 1.0 0.8 1.8 1.7 1.8 1.7 1.5 1.5
Family relationship satisfaction 0.1 0.2 0.9 -0.0 -0.1 -0.5 0.1 0.3 -0.3 -0.2 -0.1 -0.3 -0.3 -1.0 0.0 0.8 -0.3 0.8 0.6 -0.3 -0.0
Leg pain on walking 1.1 1.3 2.4 1.1 -1.5 -1.3 0.7 -1.0 -1.6 -1.1 -1.5 0.5 0.9 -1.2 1.3 1.5 -0.3 1.5 1.5 0.5 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.5 0.2 -0.5 -0.5 -0.4 -0.2 -0.1 -0.5 -0.1 -0.6 0.5 -0.1 0.2 -0.3 0.7 -0.3 -0.2 -0.1 -0.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 4.0 0.0 -0.2 -0.2 0.3 2.0 0.1 -0.3 0.0 -0.3 -0.9 0.7 -0.0 -1.0 0.8 -1.0 -0.8 0.5 0.5
Illness, injury, bereavement, stress in last 2 years 3.0 3.7 8.9 -2.5 1.1 -0.3 -1.7 0.3 0.4 2.5 2.6 -0.7 -3.0 1.3 -2.8 -2.0 -0.8 -2.0 -2.2 -2.1 -2.5
Medication: Aspirin 1.1 1.4 4.7 -0.7 1.6 2.2 -0.4 -0.3 1.9 0.9 1.3 0.2 1.5 2.0 -1.1 -1.0 0.2 -1.0 -0.9 0.4 -0.4
Supplements: Vitamin C 1.4 1.6 3.5 -1.2 -0.9 -1.0 -1.2 0.9 -0.8 1.3 0.7 -0.5 -0.3 0.8 -1.4 -1.9 -1.6 -1.9 -1.8 -1.4 -1.7
Knee pain experienced in last month 0.6 1.0 5.2 0.7 -1.6 -1.4 -0.4 -0.5 -1.8 -0.9 -1.2 0.0 -0.2 -2.3 1.0 0.1 -0.1 0.1 0.3 0.1 0.0
Hypertension (Self-reported) 1.5 4.0 13.8 1.9 1.3 1.2 2.6 1.2 1.8 -1.5 -1.2 3.2 3.7 1.0 1.4 1.8 2.1 1.8 1.9 2.1 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 6.0 0.3 -0.7 -0.4 -0.1 -1.2 -0.1 -0.1 -0.7 -0.8 0.7 -2.5 1.2 1.0 -0.7 1.0 0.9 1.0 1.2
Illnesses of father: Heart disease 1.9 2.6 6.9 1.0 2.4 2.1 0.8 -1.1 2.5 -0.8 0.1 1.5 2.6 1.7 0.7 0.8 2.6 0.8 0.9 2.0 1.5
Illnesses of siblings: Diabetes 1.9 2.3 7.2 0.4 2.3 2.5 0.8 -0.2 2.4 0.2 0.6 1.5 2.7 2.4 -0.1 0.4 1.6 0.4 0.4 1.8 1.1
Smoking status: Previous 0.8 1.3 3.2 -1.2 -0.1 0.1 -1.4 1.6 0.1 1.1 0.9 -1.0 -1.4 -0.7 -0.9 -1.8 -0.7 -1.8 -1.7 -0.7 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.1 0.9 -0.5 -0.1 1.2 0.5 -0.2 -1.1 -0.9 -0.5 1.2 0.0 1.1 1.8 0.2 1.8 1.6 1.0 1.2
Whole body fat-free mass 0.2 1.3 3.5 -1.6 0.4 0.5 -1.3 0.3 0.2 1.9 1.6 -0.4 -1.2 0.7 -1.5 -1.0 -1.2 -1.0 -1.1 -0.8 -1.4
Leg fat-free mass (right) 0.2 0.9 2.0 -1.2 0.2 0.4 -1.3 -0.9 -0.2 1.4 1.3 -1.1 -1.4 0.3 -1.0 -0.6 -1.3 -0.6 -0.8 -0.5 -1.0
Arm fat percentage (left) 0.6 2.3 5.9 -2.0 1.3 1.4 -1.6 -0.3 1.4 2.4 2.3 0.5 0.5 1.5 -1.5 -2.0 -0.3 -2.0 -2.0 0.6 -0.4
Average weekly red wine intake 0.2 0.3 1.7 0.1 0.8 0.8 0.0 -1.2 1.3 0.2 0.2 0.5 -0.0 0.8 -0.1 0.2 -0.0 0.2 0.1 -0.1 -0.0
Handedness (chirality/laterality): Left-handed 0.6 0.8 2.5 -0.9 -1.2 -0.8 -0.7 1.3 -1.0 0.8 0.2 -1.4 -0.3 -1.2 -0.5 -0.4 -1.6 -0.4 -0.5 -0.4 -0.4
Mood swings 0.2 0.4 1.7 -0.0 1.1 0.9 -0.3 -0.6 0.9 -0.2 0.3 -0.6 0.9 -1.3 0.3 -0.5 0.0 -0.5 -0.4 0.6 0.8
Loneliness, isolation 0.8 1.2 5.0 -0.8 1.9 2.2 -0.5 -0.3 1.3 1.0 1.4 0.7 1.5 0.2 -1.1 -0.8 0.6 -0.8 -0.9 -0.1 -0.4
Long-standing illness, disability or infirmity 1.0 1.5 10.5 0.3 1.5 1.9 -0.5 -3.2 1.3 0.1 0.3 1.4 2.4 -0.8 -0.2 0.1 -0.3 0.1 0.2 -0.2 -0.6
Ever had bowel cancer screening 0.7 0.8 2.5 0.5 1.0 1.6 0.7 -0.1 1.2 -0.4 0.0 1.0 1.3 -0.1 0.2 0.7 1.1 0.7 0.7 1.1 1.0
Diabetes diagnosed by doctor 1.5 2.4 6.2 1.9 0.7 1.5 1.1 -2.5 1.4 -1.5 -1.1 0.3 2.4 -0.2 1.3 1.9 0.9 1.9 2.0 1.5 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 2.6 1.4 -0.8 -1.0 0.6 1.3 -0.6 -1.6 -1.5 -0.1 0.3 -1.5 1.2 0.2 0.8 0.2 0.5 0.2 0.7
Friendships satisfaction 0.1 0.1 0.5 -0.1 -0.0 0.4 -0.1 -0.5 0.0 0.3 0.1 0.4 0.7 -0.6 0.1 0.5 -0.3 0.5 0.3 0.4 0.1
Qualifications: nursing, teaching 0.3 0.5 2.5 -0.3 0.8 0.6 -0.6 -1.4 0.6 -0.1 0.7 -0.7 -0.7 1.6 -0.7 -0.1 -0.3 -0.1 -0.2 -0.2 -0.4
Commuting to job workplace: Walk 1.7 1.9 4.7 -0.1 -2.2 -2.1 -0.9 0.1 -2.2 -0.2 -0.7 -2.0 -1.4 -1.9 -0.0 0.4 -1.9 0.4 0.3 -1.8 -1.3
Eye problems/disorders: Cataract 0.6 0.7 1.9 -1.0 1.0 1.4 -0.8 -0.1 0.8 1.1 1.2 0.1 1.0 0.0 -1.0 -0.9 -0.6 -0.9 -0.9 -0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.8 2.9 9.2 1.3 -3.0 -2.6 0.6 -0.1 -2.6 -1.7 -2.4 -1.7 -1.8 -2.2 1.8 0.8 -1.3 0.8 1.0 -0.9 0.1
Medication for cholesterol 0.5 0.8 4.3 -0.4 -0.8 -1.1 -0.5 -0.2 -0.8 0.1 -0.1 -2.1 -1.4 -1.5 -0.2 0.2 -1.3 0.2 0.0 -0.9 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.9 -0.0 0.9 0.8 -0.2 -0.4 1.0 -0.1 0.4 0.3 -0.3 0.6 -0.3 -0.5 0.6 -0.5 -0.4 -0.3 -0.3
Back pain experienced in last month 0.9 1.3 2.5 1.4 -0.5 -0.0 0.7 -1.2 -0.4 -1.4 -1.4 -0.6 1.1 -1.1 1.6 1.4 -0.1 1.4 1.5 1.3 1.4
Mineral and other dietary supplements 0.4 0.5 3.7 0.1 -0.4 -0.1 0.2 -1.5 0.1 0.0 -0.0 -1.9 -0.8 -0.5 0.0 0.9 -0.3 0.9 0.7 0.2 0.2
Breast cancer (self-reported) 0.5 0.6 1.5 0.8 -1.2 -0.7 0.6 -0.2 -0.5 -1.1 -0.9 -0.0 -1.2 -0.9 0.8 0.8 0.5 0.8 0.9 0.2 0.3
Asthma (self-reported) 0.2 0.4 3.0 0.7 1.2 0.9 0.4 -1.7 0.6 -0.7 -0.1 -0.1 -0.1 0.4 0.3 0.4 0.4 0.4 0.5 -0.0 0.5
Osteoporosis (self-reported) 0.3 0.4 1.5 0.1 0.7 -0.2 -0.2 1.1 0.3 -0.2 0.1 1.0 -0.9 -1.2 0.1 -0.8 0.6 -0.8 -0.6 0.1 0.4
Osteoarthritis (self-reported) 0.1 0.1 0.5 0.3 -0.2 0.4 0.0 0.2 -0.2 -0.2 -0.1 0.2 -0.5 0.0 -0.0 -0.5 0.7 -0.5 -0.4 -0.2 -0.3
Medication: Aspirin 1.1 1.5 3.3 -1.0 1.4 1.8 -1.0 -0.8 1.5 1.1 1.5 -0.2 1.3 1.5 -1.4 -1.4 -0.4 -1.4 -1.3 -0.3 -1.1
Medication: Gliclazide 0.5 0.6 3.2 1.0 1.2 0.9 -0.1 -1.8 1.2 -0.8 -0.5 -0.5 -0.5 0.2 0.7 -0.0 0.2 -0.0 0.2 -0.2 0.5
Illnesses of father: None of the above (group 1) 0.9 1.1 4.9 -1.2 -1.1 0.1 -0.9 0.2 -1.3 1.3 0.7 -0.3 -2.2 -0.6 -1.0 -0.5 -1.4 -0.5 -0.6 -1.2 -1.0
Smoking status: Current 2.3 3.6 9.6 -2.3 0.7 -0.1 -1.8 3.1 1.1 2.6 1.8 -0.4 0.0 0.6 -2.0 -3.0 -1.1 -3.0 -2.9 -1.1 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 6.9 1.0 1.0 0.7 0.3 -2.6 1.1 -0.8 -0.4 -1.2 -0.4 -0.2 0.6 0.8 1.3 0.8 0.9 -0.2 0.4
Whole body water mass 0.3 1.5 4.0 -1.7 0.4 0.6 -1.4 0.3 0.2 2.0 1.7 -0.4 -1.3 0.7 -1.6 -1.1 -1.2 -1.1 -1.2 -1.0 -1.5
Leg predicted mass (right) 0.2 1.0 2.1 -1.3 0.2 0.4 -1.4 -0.9 -0.2 1.4 1.3 -1.1 -1.4 0.4 -1.0 -0.7 -1.3 -0.7 -0.8 -0.5 -1.0
Arm fat mass (left) 0.4 1.8 5.6 -2.0 1.0 1.0 -1.5 -0.1 1.0 2.4 2.1 0.1 0.1 1.1 -1.4 -1.7 -0.6 -1.7 -1.8 0.3 -0.6
Number of self-reported non-cancer illnesses 1.0 1.8 8.1 1.7 1.1 1.7 1.2 -1.2 1.6 -1.3 -1.0 1.4 2.9 -0.0 1.1 0.7 1.1 0.7 1.0 1.1 1.3
Average weekly champagne plus white wine intake 1.4 1.9 4.0 1.8 0.4 0.6 2.0 0.8 1.3 -1.6 -1.4 0.5 1.8 0.2 1.5 1.4 1.6 1.4 1.5 1.2 1.9
Miserableness 0.5 0.9 5.8 -0.1 1.0 1.4 -0.3 0.1 1.4 -0.2 0.2 -0.4 2.4 -1.9 0.5 0.2 0.0 0.2 0.1 0.8 1.0
Guilty feelings 0.8 1.2 3.4 -1.1 -0.9 -0.0 -1.7 -0.4 -0.8 0.7 0.4 -1.0 -0.4 -1.9 -0.5 -1.2 -1.5 -1.2 -1.2 -1.4 -1.1
Wears glasses or contact lenses 2.5 2.9 9.6 -1.4 -1.3 -0.7 -2.0 -2.6 -1.6 1.3 0.6 0.4 -1.5 0.4 -1.5 -1.5 -1.9 -1.5 -1.4 -3.1 -2.9
Ever taken oral contraceptive pill 0.4 0.4 1.6 -0.5 0.4 1.1 -0.4 -0.7 1.3 0.8 0.6 -0.3 0.6 1.2 -0.4 -0.4 -0.4 -0.4 -0.4 0.4 0.0
Hearing aid user 1.9 2.1 5.7 -2.2 0.6 0.7 -1.7 0.9 0.7 2.4 2.0 -1.0 -0.9 -0.0 -1.7 -1.9 -1.3 -1.9 -2.0 -0.2 -0.8
Mother’s age at death 0.4 0.5 5.0 0.4 -0.6 -0.4 0.9 2.2 -0.0 -0.1 -0.4 1.1 0.4 0.5 0.2 0.4 0.4 0.4 0.3 0.7 0.6
Financial situation satisfaction 0.2 0.3 3.1 0.4 -0.3 -0.7 -0.3 -0.1 -0.4 -0.3 -0.7 0.1 -0.2 -1.8 0.6 0.1 -0.5 0.1 0.2 -0.3 0.0
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.2 -0.6 -1.1 -1.2 -0.8 1.4 -1.4 0.7 0.0 -0.9 -1.4 -1.5 -0.2 -1.4 -0.2 -1.4 -1.3 -0.6 -0.7
Commuting to job workplace: Public transport 0.5 0.6 4.6 0.7 -0.4 -0.4 0.2 -2.1 -0.7 -0.3 -0.7 0.9 0.2 0.4 0.4 1.0 -0.5 1.0 1.0 0.0 -0.0
Eye problems/disorders: Glaucoma 0.4 0.5 2.6 0.7 -0.5 0.2 0.8 1.2 -0.5 -0.5 -0.9 1.6 1.2 0.1 0.7 0.3 0.6 0.3 0.4 0.2 0.5
Medication: Blood pressure 0.9 1.8 8.7 1.2 0.8 0.8 1.4 1.3 1.1 -0.9 -0.6 2.9 0.9 1.8 0.8 0.4 2.3 0.4 0.6 1.6 1.0
Pain type(s) experienced in last month: Hip pain 2.1 2.7 5.3 -2.2 0.3 0.7 -2.2 0.6 -0.1 2.0 1.8 -1.9 -1.1 -0.8 -1.6 -2.2 -2.0 -2.2 -2.3 -1.2 -1.3
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.5 -0.7 0.2 0.4 -0.8 0.9 -0.3 0.7 0.5 0.7 -0.2 0.3 -0.7 -1.2 -0.6 -1.2 -1.1 -1.1 -0.9
High cholesterol (Self-reported) 0.3 0.5 3.5 0.4 0.1 0.6 0.6 0.1 0.6 -0.3 -0.3 0.8 1.9 -0.0 0.4 0.2 1.1 0.2 0.2 1.0 0.8
Medication: Bendroflumethiazide 2.9 4.4 11.4 2.1 1.9 1.6 2.7 1.5 2.2 -1.4 -0.9 2.4 2.3 1.4 1.7 1.4 3.4 1.4 1.5 3.3 2.8
Medication: Paracetamol 0.4 0.7 3.0 -0.5 -0.2 0.1 -1.0 -0.8 0.1 0.6 0.1 -0.4 0.7 -0.5 0.0 -1.7 -0.8 -1.7 -1.5 0.1 0.1
Medication: Lisinopril 1.7 2.2 3.8 1.7 -0.8 -0.3 1.9 1.4 0.1 -1.4 -1.6 1.9 1.7 -0.5 1.6 1.8 1.3 1.8 1.8 1.6 1.3
Medication: Atorvastatin 0.9 1.1 3.3 -1.2 1.6 1.8 -0.5 -0.7 1.2 1.0 1.7 0.6 0.4 0.5 -1.5 -0.7 -0.3 -0.7 -0.8 -0.5 -0.8
Illnesses of father: High blood pressure 1.5 1.8 5.7 2.0 -0.7 -1.3 1.7 0.0 0.1 -2.4 -2.0 -0.3 1.5 -0.9 1.5 1.5 1.1 1.5 1.6 0.4 0.8
Alcohol drinker status: Never 1.2 1.4 5.6 -1.0 0.0 -0.0 -1.3 -2.4 -0.7 0.6 0.7 -1.0 0.1 -0.1 -1.1 -0.6 -1.3 -0.6 -0.7 -2.3 -2.3
Ever smoked 2.5 4.4 10.2 -2.4 -0.3 -0.5 -2.2 2.7 -0.3 2.3 1.6 -1.5 -2.0 0.1 -2.1 -3.2 -1.9 -3.2 -3.2 -2.2 -1.9
Basal metabolic rate 0.3 1.5 4.1 -1.8 0.4 0.5 -1.6 0.2 0.1 2.0 1.7 -0.5 -1.2 0.7 -1.5 -1.2 -1.3 -1.2 -1.4 -0.8 -1.4
Leg fat percentage (left) 1.1 3.9 7.6 -2.2 2.1 2.3 -1.6 1.0 2.2 2.8 2.6 1.8 1.7 1.6 -1.8 -2.6 -0.2 -2.6 -2.6 0.9 -0.3
Arm fat-free mass (left) 0.2 1.1 3.5 -1.6 0.4 0.5 -1.3 0.3 0.1 1.9 1.6 -0.0 -0.9 0.5 -1.5 -0.8 -1.1 -0.8 -1.1 -0.8 -1.4
Number of operations (self-reported) 1.8 2.6 5.3 2.3 -0.8 -1.0 1.8 0.5 -0.2 -2.3 -2.3 -0.7 0.9 -1.8 2.1 1.9 1.5 1.9 2.1 0.9 1.5
Average weekly beer plus cider intake 0.8 1.2 3.9 -1.1 -1.4 -0.7 -0.6 1.3 -2.0 0.8 0.3 -0.1 -0.9 0.6 -1.1 -0.6 -1.5 -0.6 -0.7 -1.6 -1.7
Irritability 1.2 2.0 8.3 1.0 1.5 1.6 0.9 0.5 2.0 -1.0 -0.2 1.7 2.9 0.9 0.8 1.0 1.4 1.0 1.0 1.9 1.7
Risk taking 0.3 0.5 1.8 -0.1 1.4 1.3 -0.0 -1.0 1.1 0.2 0.6 0.6 -0.4 1.2 -0.2 -0.3 0.4 -0.3 -0.3 0.4 0.1
Ever had prostate specific antigen (PSA) test 1.6 1.8 6.0 -1.0 2.0 2.5 -1.1 -0.3 2.1 1.2 1.6 -0.0 0.4 1.2 -1.2 -1.7 -0.1 -1.7 -1.6 0.0 -0.3
Fractured/broken bones in last 5 years 0.2 0.3 1.1 0.7 0.5 0.3 0.6 0.1 0.9 -0.2 -0.4 0.5 0.7 0.1 0.3 -0.5 1.1 -0.5 -0.3 0.1 0.1
Age started oral contraceptive pill 0.3 0.4 2.5 0.1 1.0 0.2 -0.0 -1.3 0.2 -0.0 0.4 0.6 -0.0 0.8 -0.2 0.0 1.6 0.0 0.0 0.0 0.1
Diastolic blood pressure, automated reading 0.5 1.7 7.0 1.6 -0.4 -1.1 1.9 1.1 -0.6 -1.6 -1.7 2.6 0.1 0.2 1.6 1.1 1.1 1.1 1.2 0.4 1.0
Ever depressed for a whole week 0.5 0.6 2.0 -0.6 -0.4 -0.5 -1.2 -0.0 0.6 0.6 0.1 -0.0 1.4 -0.9 -0.3 -1.0 -0.6 -1.0 -0.9 -1.0 -1.0
Unable to work because of sickness or disability 0.5 0.7 2.2 -0.5 0.6 0.4 -1.0 -0.1 0.0 0.6 0.4 -0.1 1.5 -0.8 -0.5 -1.4 -0.6 -1.4 -1.2 -0.3 -0.8
Commuting to job workplace: Cycle 1.3 1.6 5.9 0.6 -1.8 -1.9 0.8 -0.3 -2.4 -0.7 -1.1 -2.2 -0.0 -1.2 0.5 1.5 -0.6 1.5 1.3 -0.6 0.0
Myopia 1.7 2.4 13.2 -0.3 -1.6 -0.7 -1.3 -3.6 -1.6 0.0 -0.7 -2.0 -0.9 -1.6 0.1 0.4 -2.8 0.4 0.3 -2.4 -1.1
Vascular/heart problems diagnosed by doctor 0.8 2.2 8.9 -1.4 -1.0 -1.0 -1.9 -0.6 -1.3 1.0 0.8 -2.7 -3.0 -0.7 -0.9 -1.4 -1.5 -1.4 -1.4 -1.3 -1.2
Cholesterol lowering medication 0.4 0.5 2.7 0.1 0.7 0.9 0.6 1.1 0.5 -0.1 0.2 1.6 1.1 0.4 -0.0 0.2 1.1 0.2 0.2 0.9 0.6
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 3.3 0.0 0.2 0.2 -0.1 -1.3 1.4 0.1 0.0 -0.7 1.2 -0.9 0.6 0.3 0.6 0.3 0.3 1.8 1.3
Pain experienced in last month 1.6 2.7 5.8 -2.1 1.5 0.8 -1.2 0.4 1.5 1.9 2.2 1.0 -1.1 1.4 -2.4 -1.7 -0.8 -1.7 -1.8 -2.0 -2.2
Supplements: Calcium 1.1 1.2 3.4 -1.2 1.0 0.0 -1.4 -0.4 1.4 1.0 1.2 0.0 -0.7 0.0 -0.8 -1.8 -0.3 -1.8 -1.7 -0.6 -0.7
Basal cell carcinoma (self-reported) 1.2 1.4 3.7 1.5 -0.5 -0.2 1.6 0.9 -0.0 -1.6 -1.2 1.9 -0.1 0.1 1.4 1.3 1.3 1.3 1.3 1.1 1.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 6.2 -0.3 1.1 1.4 -0.5 -2.5 1.8 0.2 0.5 -0.6 1.4 0.1 -0.1 0.1 -0.5 0.1 0.1 0.6 0.5
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 6.6 1.0 1.4 1.5 1.3 1.2 1.1 -0.8 -0.1 1.8 2.6 0.6 0.6 0.7 2.0 0.7 0.8 1.8 1.4
Heart disease (siblings) 0.1 0.2 1.0 0.2 0.2 -0.0 -0.3 -1.0 0.1 -0.6 -0.2 -0.4 -0.1 -0.8 0.2 0.2 0.1 0.2 0.2 0.3 0.4
Alcohol drinker status: Previous 0.6 0.7 3.6 0.8 -0.8 -0.3 -0.2 -1.9 -0.6 -0.8 -1.3 0.7 1.0 -1.3 1.0 0.1 -1.0 0.1 0.3 -0.6 0.1
Pack years of smoking 0.4 0.6 2.8 -0.5 0.9 0.8 -0.3 0.0 0.9 0.9 0.8 1.7 0.0 0.1 -0.7 -1.1 0.6 -1.1 -1.0 -0.2 -0.5
Impedance of whole body 0.2 1.0 3.3 1.2 -0.1 0.2 1.3 1.3 0.1 -1.1 -1.0 0.2 1.8 -0.2 1.0 0.2 1.3 0.2 0.4 1.4 1.5
Leg fat mass (left) 0.9 3.4 8.6 -2.5 1.5 1.6 -1.9 0.8 1.5 2.9 2.7 0.8 0.6 1.5 -2.1 -2.5 -0.7 -2.5 -2.6 0.2 -1.0
Arm predicted mass (left) 0.3 1.5 4.5 -1.9 0.6 0.7 -1.5 0.4 0.3 2.1 1.8 -0.0 -0.9 0.6 -1.7 -1.1 -1.0 -1.1 -1.4 -0.9 -1.5