Hub : Genes

RP11-336K24.12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1725 0.0744 0.0075 0.021 NA -0.005 NA 0.007 0.05900 NA 0.550 NA 0.1700
2 GTEx Breast Mammary Tissue (Female) 0.0676 0.0501 0.0890 -0.009 NA -0.010 NA -0.008 0.76000 NA 0.960 NA 0.6700
3 GTEx Nerve Tibial 0.1431 0.0516 0.0016 0.054 NA 0.013 NA 0.032 0.00011 NA 0.038 NA 0.0025

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.0 2.9 -0.4 1.7 -0.3
Bipolar Disorder or Schizophrenia 1.0 2.4 4.1 1.8 2.0 -0.1
Depressed Affect (Nagel 2018) 0.4 0.9 1.3 -1.1 1.1 0.4
Depression (Nagel 2018) 1.3 1.9 4.6 0.8 2.1 0.8
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.3 1.5 0.3 0.3
Neuroticism (Nagel 2018) 0.2 0.4 1.0 -0.2 0.3 1.0
Schizophrenia (2018) 1.3 2.7 6.7 2.6 1.2 0.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.4 1.2 -0.2 0.1
Worry (Nagel 2018) 0.2 0.4 0.9 0.1 -0.7 0.9
Alzheimer’s Disease (in mother) 0.3 0.4 0.8 -0.9 0.4 -0.4
Alzheimer’s Disease (in father) 1.1 1.2 3.2 -0.7 -1.8 -0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.1 -1.0 -0.5 0.6
Crohns Disease (2017) 3.0 6.5 18.6 -0.4 4.3 -0.8
Irritable Bowel Disease (IBD) 1.9 4.5 13.0 0.6 3.6 -0.5
Ulcerative Colitis (UC) 0.8 1.6 3.2 1.2 1.8 0.1
Major Depression (MDD) 1.9 2.4 5.1 -2.3 0.8 -1.1
Reaction Time 1.1 2.2 6.0 -0.5 2.5 0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.7 0.9 0.3 -0.3
Breast Cancer 3.1 7.4 11.6 -3.3 -3.4 0.1
Ovarian Cancer 0.5 0.6 1.3 -0.8 0.2 1.1
Prostate Cancer 1.9 2.7 6.4 2.5 -0.1 -1.3
Age at First Birth 2.3 3.3 9.3 3.0 -0.7 0.4
Bipolar Disorder (2011) 1.9 1.8 4.1 -2.0 1.2 0.1
Body Mass Index (BMI) (2010) 3.5 4.8 9.1 -2.3 -3.0 0.5
Coronary Artery Disease (CAD) 1.0 1.2 3.1 -1.8 0.1 -0.6
Crohns Disease (2012) 5.2 8.4 24.3 0.1 4.9 -0.9
Mean Putamen Volume 2.3 2.6 6.0 0.6 2.4 1.2
Fasting Glucose 0.9 1.0 2.7 0.6 0.0 -1.6
HbA1C 0.5 0.5 1.2 0.5 -1.1 0.2
HDL Cholesterol 1.0 1.6 4.5 0.3 -2.1 -0.6
LDL Cholesterol 0.9 1.4 3.8 0.1 2.0 -0.6
Lupus 1.4 2.1 2.2 -1.4 1.4 1.5
Neuroticism (2016) 0.7 1.1 1.6 -1.3 0.7 -1.0
Primary Biliary Cirrhosis 0.1 0.1 0.2 0.1 -0.4 0.4
Rheumatoid Arthritis 0.7 1.0 2.4 0.5 -1.5 0.5
Schizophrenia (2014) 1.1 2.5 4.4 2.1 1.6 0.7
Triglycerides 0.2 0.3 0.4 -0.5 0.6 0.5
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.4 1.9 0.8 0.2
Ulcerative Colitis 0.6 0.9 1.1 1.1 0.7 1.0
Blood Eosinophil Count 0.5 4.0 8.8 -3.0 -1.6 -0.9
Blood Platelet Count 0.5 5.4 10.6 -3.2 1.3 -2.0
Blood Red Count 0.4 4.2 8.8 3.0 -0.3 -1.9
Blood White Count 2.1 15.5 44.2 -6.7 1.2 -0.9
Heel T-Score 0.6 5.2 9.8 -2.4 3.1 0.2
BMI 2.5 14.5 29.2 -5.4 -3.3 -1.8
Height 0.4 6.8 12.8 3.6 1.9 2.0
Waist Hip Ratio (WHR) 0.3 1.5 2.2 1.3 0.8 1.5
Systolic Blood Pressure 0.0 0.1 0.1 0.1 0.4 -0.3
Smoking Status 0.5 1.2 1.8 -1.1 1.3 -0.9
Allergy or Eczema 3.2 8.3 21.3 1.9 4.6 -0.3
Cardiovascular Disease 0.4 1.3 3.2 -1.8 0.9 -0.2
Hypothyroidism (self reported) 0.6 1.5 3.2 0.9 1.8 0.7
Respiratory disease 0.8 1.7 4.5 -0.5 2.1 0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.5 -0.1 -0.7 0.1
Lung FEV1/FVC ratio 0.2 1.2 1.8 1.4 1.1 0.8
Lung FVC 0.3 1.7 4.0 0.7 -2.0 0.7
Neuroticism 0.1 0.2 0.6 -0.7 0.0 -0.1
Chronotype (morning person) 0.8 1.8 4.0 0.5 1.0 -2.0
Hair Pigment 0.5 13.7 35.5 2.0 6.0 -1.2
Tanning 0.3 4.2 12.0 -0.3 3.5 0.7
Hand grip strength (left) 0.4 1.1 2.5 0.7 1.6 -0.4
Number of treatments/medications taken 1.4 2.5 7.4 -2.7 0.2 0.0
Average weekly spirits intake 0.5 0.6 1.1 -1.1 -0.2 0.8
Sensitivity / hurt feelings 0.3 0.5 1.0 -0.6 -1.0 -0.5
Frequency of depressed mood in last 2 weeks 1.7 2.4 6.1 0.2 2.5 1.1
Hearing difficulty/problems: Yes 0.3 0.4 1.0 -1.0 -0.2 0.4
Relative age of first facial hair 0.1 0.1 0.2 -0.2 0.5 0.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 0.3 0.2 -1.0
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.4 0.3 -0.6 0.1
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 0.1 0.1 -0.0
Systolic blood pressure, automated reading 0.8 2.4 5.0 -1.4 -0.4 -2.2
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.1 -0.9 -1.0 -0.1
Angina 0.1 0.1 0.1 -0.4 0.3 0.2
Medication for hormone replacement therapy 0.5 0.6 1.1 -0.8 1.1 0.1
Vitamin and mineral supplements 0.6 0.8 2.0 0.1 0.6 1.4
Supplements: Zinc 1.5 1.7 4.6 -0.6 -0.0 -2.1
Medication: Co-codamol 2.7 3.2 9.1 -3.0 0.3 0.6
Medication: Metformin 0.5 0.6 1.8 0.1 -0.3 -1.3
Diabetes (father) 0.2 0.2 0.5 -0.7 0.4 -0.1
Diabetes (mother) 0.3 0.4 1.1 -0.3 -0.3 -1.0
Severe depression (siblings) 0.4 0.5 1.2 -0.3 0.3 1.1
Pack years adult smoking proportion 3.0 4.6 10.0 -3.2 1.6 -1.0
Impedance of leg (right) 1.3 6.4 8.5 2.9 2.9 1.5
Leg fat-free mass (left) 0.4 2.1 3.8 -0.7 -2.0 -1.4
Trunk fat percentage 1.7 6.6 9.6 -2.6 -3.1 -1.9
Hand grip strength (right) 0.1 0.2 0.3 0.6 0.5 0.3
Townsend deprivation index at recruitment 2.0 2.8 7.8 -2.8 0.4 0.6
Current tobacco smoking 1.7 2.8 4.0 -2.0 1.8 -1.1
Average weekly fortified wine intake 0.2 0.3 0.7 -0.9 0.2 -0.2
Maternal smoking around birth 0.3 0.5 1.1 -1.1 -0.5 -0.1
Fed-up feelings 0.2 0.5 0.8 -0.9 0.5 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 0.4 0.8 0.0
Relative age voice broke 0.9 1.4 2.4 -0.0 1.5 -1.4
Taking other prescription medications 0.9 1.4 3.9 -2.0 0.4 0.2
Age when periods started (menarche) 0.0 0.1 0.1 -0.3 0.3 0.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.5 -0.5 1.2 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.2 6.1 -2.5 1.9 -1.7
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.3 -1.4 -0.3 -1.5
Qualifications: CSEs or equivalent 1.3 1.8 4.8 0.7 2.2 -0.3
Serious illness, injury or assault to yourself 0.1 0.1 0.1 0.2 -0.3 -0.3
High blood pressure 0.1 0.3 0.7 -0.6 0.1 -0.8
Hayfever, allergic rhinitis or eczema 2.6 5.7 11.7 1.9 3.4 1.3
Multivitamins +/- minerals 1.2 1.6 4.0 -0.8 0.2 -2.0
Stomach or abdominal pain in last month 0.3 0.4 0.7 -0.9 0.5 0.4
Supplements: Glucosamine 0.0 0.0 0.0 0.1 0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.0 0.9 -1.0 0.8
Medication: Atenolol 0.4 0.5 1.2 -1.1 -0.1 -0.6
Medication: Levothyroxine sodium 0.2 0.4 1.1 1.1 -0.1 0.2
Sitting height 0.9 6.1 17.7 4.2 0.6 0.2
Chronic bronchitis/emphysema (father) 1.2 1.4 1.5 -1.1 -1.2 1.2
High blood pressure (mother) 0.9 1.3 3.2 -0.2 -1.8 0.7
Body mass index (BMI) 2.0 8.5 12.0 -3.5 -2.6 -2.6
Impedance of leg (left) 1.1 5.2 8.4 2.5 2.9 1.0
Leg predicted mass (left) 0.4 2.2 4.1 -0.7 -2.0 -1.4
Trunk fat mass 1.4 5.8 8.3 -2.1 -2.9 -2.1
Waist circumference 0.5 1.8 2.3 -1.5 -1.2 -1.3
Number of incorrect matches in round 1.4 2.3 5.1 2.3 -1.0 1.0
Past tobacco smoking 0.3 0.5 1.0 -0.2 -1.0 -0.8
Alcohol usually taken with meals 1.8 2.9 8.5 2.9 0.0 0.2
Nervous feelings 1.9 3.5 7.9 -1.6 -2.8 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.4 0.4 1.2 -0.6
Hearing difficulty/problems with background noise 0.4 0.6 0.9 -0.6 -0.7 1.0
Hair/balding pattern: Pattern 2 1.8 2.3 4.7 -1.4 2.2 0.4
Had menopause 1.6 2.0 4.7 -0.5 -2.2 -1.0
Had other major operations 0.8 1.0 1.4 -0.8 0.9 -1.2
Forced vital capacity (FVC) 0.6 2.3 5.8 2.4 -0.0 1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 4.7 -1.6 2.2 -1.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.7 -0.4 -0.2 -0.9
Qualifications: None of the above 1.4 2.9 5.6 -2.4 -1.6 -0.8
Financial difficulties in last 2 years 0.9 1.1 2.4 -1.6 -0.8 -0.6
Mouth/teeth dental problems 0.3 0.4 0.9 0.9 -0.5 0.4
Heart attack 1.7 2.2 6.2 -2.5 0.1 -0.6
Allergy 1.3 3.1 7.6 -1.1 -2.8 -0.8
Pain all over the body in last month 0.9 0.9 2.5 -0.5 -1.6 0.0
Diabetes (self-reported) 0.2 0.3 0.7 0.1 -0.8 -0.3
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 3.9 1.5 2.0 -1.1
Medication: Ramipril 1.1 1.4 3.2 1.8 1.0 0.0
Medication: Simvastatin 0.3 0.5 1.0 -0.5 -1.0 -0.3
Fluid intelligence score 0.2 0.4 0.6 0.8 0.8 -0.2
Illnesses of siblings 0.4 0.6 1.7 -0.1 -0.3 -1.3
Neuroticism score 0.1 0.2 0.5 -0.7 0.5 0.0
Weight 0.7 3.3 4.1 -1.3 -2.0 -2.0
Impedance of arm (right) 0.6 3.0 5.2 1.2 -1.5 2.3
Arm fat percentage (right) 2.9 11.4 16.3 -3.7 -4.0 -2.1
Trunk fat-free mass 0.2 1.1 1.7 1.3 -0.2 -1.3
Hip circumference 0.5 2.3 3.3 -1.1 -1.5 -1.8
Time employed in main current job 1.7 2.0 3.7 -1.2 -1.9 0.8
Alcohol intake versus 10 years previously 0.7 1.1 2.1 -0.8 1.4 -0.7
Father’s age at death 1.0 1.3 2.0 1.4 -0.9 1.1
Worrier / anxious feelings 1.8 3.4 7.0 -0.7 -2.6 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.0 -1.0 1.0 -0.3
Falls in the last year 1.3 1.7 2.7 -1.6 1.3 0.8
Hair/balding pattern: Pattern 3 0.7 1.0 2.6 0.5 -0.3 1.6
Number of live births 0.4 0.6 1.5 -0.2 0.6 -1.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.5 6.7 2.6 0.3 0.9
Pulse rate 0.3 0.6 1.0 1.0 0.6 -0.6
Happiness 0.3 0.3 0.7 -0.1 0.5 -0.8
Noisy workplace 0.0 0.0 0.0 -0.1 0.0 -0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.0 1.4 1.0 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.2 0.4 1.1 0.2
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.6 0.2 -0.4
Asthma 0.4 0.7 1.2 -0.2 1.0 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 2.7 -0.6 -1.6 1.6
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.5 -0.1 0.2
Depression (self-reported) 0.5 0.7 1.1 -0.8 1.0 -0.4
Medication: Lansoprazole 0.7 0.8 1.6 -0.8 1.3 0.4
Prospective memory result 3.8 4.7 13.8 -0.4 0.3 3.7
Lung cancer (father) 0.7 0.8 1.4 -0.3 1.0 -1.2
Illnesses of mother 1.3 1.6 4.7 0.2 2.2 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 8.4 2.9 0.1 1.4
Pulse wave Arterial Stiffness index 0.4 0.5 0.9 0.9 0.3 0.7
Impedance of arm (left) 0.5 2.5 5.2 1.1 -1.1 2.3
Arm fat mass (right) 2.0 8.0 10.7 -2.7 -3.3 -2.4
Trunk predicted mass 0.2 1.2 1.8 1.4 -0.2 -1.3
Standing height 0.8 7.7 21.2 4.6 0.9 1.0
Length of working week for main job 0.2 0.2 0.5 -0.1 -0.7 -0.3
Exposure to tobacco smoke at home 1.5 1.7 3.6 -1.9 0.4 -1.1
Breastfed as a baby 0.1 0.1 0.2 0.2 -0.0 -0.4
Tense / ‘highly strung’ 1.1 1.8 4.5 1.0 2.1 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.3 -1.5 0.7 0.6
Hair/balding pattern: Pattern 4 0.4 0.9 1.9 0.7 -1.4 0.5
Birth weight of first child 1.1 2.0 5.7 0.5 -2.4 0.4
Peak expiratory flow (PEF) 0.3 0.8 1.2 1.0 -1.1 0.4
Pulse wave reflection index 0.4 0.5 1.0 0.1 1.0 0.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.8 -0.9 0.5 0.2
Loud music exposure frequency 0.4 0.5 0.9 -0.7 -0.9 -0.3
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 3.7 1.9 0.8 0.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 -1.0 0.5 0.2
Blood clot in the leg (DVT) 0.5 0.6 1.7 -1.3 0.2 0.3
Medication: Paracetamol 1.1 1.9 3.3 -1.8 -1.0 1.1
Headache pain in last month 0.7 1.1 1.7 -1.1 0.7 1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.9 0.3 -0.9 0.2
Glaucoma (self-reported) 0.8 0.9 2.1 0.8 0.0 1.5
Gout (self-reported) 0.0 0.0 0.1 -0.1 0.1 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 1.0 0.4 0.4
Medication: Amlodipine 0.3 0.4 1.1 -0.2 -0.1 1.1
Medication: Ventolin 100micrograms inhaler 1.4 1.8 5.1 -2.2 -0.1 0.5
Birth weight 3.5 7.5 19.2 -1.5 -4.4 -1.1
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 -0.4 0.2 -0.2
High blood pressure (siblings) 0.3 0.4 1.2 -0.1 -0.1 1.1
Forced vital capacity (FVC), Best measure 0.8 2.9 7.7 2.8 -0.1 1.0
Body fat percentage 1.8 7.3 8.6 -2.9 -2.9 -2.2
Leg fat percentage (right) 1.1 4.1 6.1 -2.5 -1.3 -2.1
Arm fat-free mass (right) 0.3 1.6 4.0 0.8 0.5 -2.0
Exposure to tobacco smoke outside home 1.0 1.3 2.4 0.3 1.5 1.2
Comparative body size at age 10 2.9 8.0 16.1 -4.0 -2.5 -1.3
Number of full brothers 2.6 3.3 8.1 -0.1 2.9 -1.3
Worry too long after embarrassment 0.4 0.6 1.0 1.0 0.9 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 5.1 -1.5 2.3 -0.3
Wheeze or whistling in the chest in last year 1.2 2.2 4.0 -0.9 2.0 -1.4
Number of children fathered 1.7 1.9 5.3 0.4 2.3 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.6 0.3 0.5
Age at first live birth 1.8 3.2 6.0 2.4 -1.3 1.4
Pulse wave peak to peak time 0.1 0.2 0.2 -0.5 -0.3 -0.4
Health satisfaction 0.6 0.8 1.3 -1.1 0.1 -1.0
Shortness of breath walking on level ground 0.1 0.2 0.3 -0.5 -0.2 -0.5
Qualifications: College or University degree 0.8 2.4 7.1 2.7 -0.1 -0.4
Eye problems/disorders: None of the above 0.8 0.9 1.1 -0.8 -1.0 -1.1
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.6 -0.6 0.3 -1.3
Emphysema/chronic bronchitis 1.1 1.2 1.5 -0.8 1.2 -1.2
Medication for pain relief, constipation, heartburn 1.1 1.9 3.1 1.8 1.3 -1.0
Neck or shoulder pain in last month 0.3 0.5 0.9 -1.0 -0.5 -0.5
Medication: Blood pressure 0.1 0.1 0.2 0.5 0.4 0.2
Angina (self-reported) 0.0 0.0 0.1 -0.3 0.0 0.0
Migraine (self-reported) 0.2 0.2 0.5 -0.4 -0.1 0.7
Medication: Ibuprofen 1.3 1.6 2.9 -0.2 -1.3 1.7
Medication: Allopurinol 0.0 0.1 0.1 -0.2 -0.2 0.2
Medication: Omeprazole 0.6 0.7 1.7 0.6 -0.4 -1.3
Medication: Seretide 50 evohaler 0.7 0.8 2.1 -0.5 -0.4 1.4
Mean time to correctly identify matches 1.0 1.9 3.1 -1.5 1.8 -0.4
Heart disease (mother) 3.2 3.9 5.9 -2.4 -2.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.0 3.6 6.2 2.0 0.8 -2.5
Whole body fat mass 1.5 6.3 8.0 -2.3 -2.8 -2.4
Leg fat mass (right) 1.3 5.2 6.6 -2.6 -1.9 -2.3
Arm predicted mass (right) 0.3 1.5 3.8 0.8 0.3 -2.0
Pulse rate, automated reading 0.7 2.1 5.0 -0.7 -0.9 -2.2
Alcohol intake frequency. 1.9 4.3 8.3 -2.9 -0.9 -1.9
Comparative height size at age 10 0.4 2.1 2.9 1.7 -1.0 -1.6
Number of full sisters 0.8 0.9 2.7 0.2 0.1 -1.6
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.0 -0.2 0.5
Overall health rating 2.3 4.9 8.0 -2.8 -1.9 -1.8
Chest pain or discomfort 2.7 3.9 8.6 -1.7 2.9 0.5
Had major operations 0.3 0.3 0.7 -0.2 0.8 -0.5
Age at last live birth 4.1 6.0 14.1 3.8 -0.9 1.8
Family relationship satisfaction 1.4 1.7 2.8 0.4 1.7 -1.5
Leg pain on walking 2.3 2.9 8.7 -3.0 0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.5 -1.1 -0.7 1.2
Commuting to job workplace: Car/motor vehicle 1.8 2.0 6.1 -0.1 0.0 2.5
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.4 1.2 0.6 0.6
Medication: Aspirin 0.2 0.3 0.5 -0.5 -0.7 0.1
Supplements: Vitamin C 1.3 1.5 2.8 0.6 -1.7 -1.2
Knee pain experienced in last month 0.5 0.7 1.5 -1.2 0.7 0.3
Hypertension (Self-reported) 0.1 0.2 0.4 -0.7 0.1 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.7 0.5 0.8 -0.5
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.2 -0.6 0.4
Illnesses of siblings: Diabetes 0.1 0.1 0.2 -0.5 -0.1 0.3
Smoking status: Previous 0.3 0.4 0.9 0.4 0.9 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.2 1.5 0.4 1.4
Whole body fat-free mass 0.2 1.2 2.5 0.5 -0.9 -1.6
Leg fat-free mass (right) 0.4 2.1 3.6 -0.7 -1.9 -1.5
Arm fat percentage (left) 2.6 10.4 14.2 -3.5 -3.8 -2.2
Average weekly red wine intake 1.6 2.3 6.0 2.5 0.9 -0.2
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.7 -0.3 0.8 -0.3
Mood swings 0.1 0.2 0.6 -0.7 0.1 -0.3
Loneliness, isolation 0.5 0.6 1.2 -0.2 0.9 1.1
Long-standing illness, disability or infirmity 1.3 2.0 4.1 -2.0 0.4 -1.3
Ever had bowel cancer screening 0.4 0.5 0.6 -0.7 0.8 0.7
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.0 -0.7 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.7 0.5 0.5 1.3
Friendships satisfaction 0.3 0.3 0.6 0.3 0.6 -0.8
Qualifications: nursing, teaching 0.4 0.6 0.8 0.8 0.5 0.9
Commuting to job workplace: Walk 0.4 0.4 0.6 0.6 -0.5 -0.8
Eye problems/disorders: Cataract 0.7 0.8 1.8 0.6 1.4 0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.3 0.3 1.5 -0.3
Medication for cholesterol 0.7 1.1 2.6 1.6 -0.9 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 2.9 0.5 -1.3 1.7
Back pain experienced in last month 0.8 1.2 1.9 1.4 -0.7 1.1
Mineral and other dietary supplements 0.4 0.5 1.0 -0.7 -1.0 0.1
Breast cancer (self-reported) 1.7 2.0 3.6 -0.8 1.3 -1.9
Asthma (self-reported) 0.5 0.9 1.7 -0.4 1.3 1.0
Osteoporosis (self-reported) 0.2 0.3 0.8 0.0 -0.2 0.9
Osteoarthritis (self-reported) 0.3 0.3 0.9 0.3 -0.9 0.3
Medication: Aspirin 0.3 0.4 0.9 -0.5 -0.9 -0.2
Medication: Gliclazide 0.2 0.3 0.7 -0.3 -0.8 -0.0
Illnesses of father: None of the above (group 1) 1.4 1.7 3.1 1.0 1.7 -1.1
Smoking status: Current 1.2 1.9 2.4 -1.5 1.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 0.4 0.5 0.5 0.7
Whole body water mass 0.2 1.2 2.6 0.5 -0.8 -1.6
Leg predicted mass (right) 0.4 2.1 3.4 -0.7 -1.8 -1.5
Arm fat mass (left) 1.7 6.9 9.4 -2.4 -3.1 -2.3
Number of self-reported non-cancer illnesses 0.4 0.7 1.2 -1.1 0.8 0.5
Average weekly champagne plus white wine intake 1.4 1.9 5.5 2.3 -0.4 0.2
Miserableness 0.5 0.9 1.2 -0.6 1.0 1.1
Guilty feelings 1.4 2.1 4.4 1.4 2.1 0.1
Wears glasses or contact lenses 1.4 1.7 3.5 0.7 -1.9 -1.0
Ever taken oral contraceptive pill 1.0 1.1 1.9 -0.9 0.8 -1.4
Hearing aid user 1.6 1.9 5.1 -0.6 0.4 2.2
Mother’s age at death 1.6 2.0 3.1 1.5 -1.8 0.8
Financial situation satisfaction 2.1 2.6 7.2 -0.3 0.6 -2.7
Tinnitus: Yes, now most or all of the time 0.5 0.5 0.7 -0.8 0.5 0.8
Commuting to job workplace: Public transport 1.6 2.0 3.4 -0.3 -1.5 -1.8
Eye problems/disorders: Glaucoma 0.8 0.9 2.0 0.8 -0.5 1.4
Medication: Blood pressure 0.5 0.9 1.6 -1.0 0.5 1.3
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 -0.8 1.2 0.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 0.2 1.0 -0.5
High cholesterol (Self-reported) 1.4 2.4 6.8 -2.6 0.7 0.0
Medication: Bendroflumethiazide 0.4 0.6 1.4 -1.2 -0.5 -0.6
Medication: Paracetamol 0.8 1.2 2.0 -1.4 -1.1 0.7
Medication: Lisinopril 1.0 1.3 3.5 -0.2 -1.9 0.5
Medication: Atorvastatin 1.8 2.3 3.6 -1.9 1.2 -1.3
Illnesses of father: High blood pressure 0.3 0.4 1.0 1.0 0.3 0.0
Alcohol drinker status: Never 0.6 0.7 1.9 -0.2 1.4 -0.2
Ever smoked 0.1 0.3 0.7 -0.2 0.8 -0.2
Basal metabolic rate 0.3 1.5 3.2 0.0 -1.1 -1.8
Leg fat percentage (left) 1.4 5.2 7.4 -2.7 -1.4 -2.5
Arm fat-free mass (left) 0.3 1.3 3.3 0.5 -0.5 -1.8
Number of operations (self-reported) 0.7 1.0 1.6 -1.3 1.1 -0.6
Average weekly beer plus cider intake 0.1 0.2 0.4 -0.2 -0.3 0.7
Irritability 0.3 0.5 1.2 -0.5 1.1 0.3
Risk taking 3.3 4.8 9.8 3.1 2.1 -0.1
Ever had prostate specific antigen (PSA) test 1.7 2.0 5.8 -0.0 -2.4 -0.4
Fractured/broken bones in last 5 years 0.8 1.1 1.9 0.7 1.4 -1.0
Age started oral contraceptive pill 1.0 1.2 3.0 0.2 -1.7 -0.8
Diastolic blood pressure, automated reading 0.7 2.3 4.0 -0.6 -1.5 -2.0
Ever depressed for a whole week 0.4 0.5 1.4 -0.3 1.2 0.3
Unable to work because of sickness or disability 1.5 1.9 4.1 -1.2 0.4 -2.0
Commuting to job workplace: Cycle 0.5 0.6 1.5 1.2 0.5 -0.1
Myopia 1.0 1.5 3.5 1.9 -0.4 0.9
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.7 1.3 -0.5 0.7
Cholesterol lowering medication 0.6 0.9 2.2 -1.5 0.3 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.4 0.2 -0.4 -1.2
Pain experienced in last month 0.7 1.2 1.7 0.8 1.3 -1.1
Supplements: Calcium 0.4 0.4 0.6 -0.1 -0.8 -0.8
Basal cell carcinoma (self-reported) 1.9 2.3 6.1 0.1 -0.8 -2.5
Heart attack/myocardial infarction (self-reported) 1.6 2.1 6.2 -2.5 0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.4 -1.6 0.7 0.3
Heart disease (siblings) 0.7 0.8 2.2 -1.5 -0.6 0.1
Alcohol drinker status: Previous 0.4 0.4 0.7 -0.5 0.6 -0.8
Pack years of smoking 2.3 3.4 7.8 -2.8 1.4 -0.7
Impedance of whole body 0.6 3.0 4.9 2.2 0.8 1.8
Leg fat mass (left) 1.5 5.8 6.9 -2.6 -2.0 -2.5
Arm predicted mass (left) 0.2 1.1 3.1 0.4 -0.3 -1.8