Hub : Genes

MSTO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2100	0.0860	0.00056	0.000	NA	0.035	NA	0.032	3.3e-01	NA	4.6e-02	NA	5.3e-02
2	GTEx	Brain Cerebellum	0.1550	0.0660	0.00044	0.061	NA	0.071	NA	0.043	7.3e-03	NA	4.0e-03	NA	2.0e-02
3	YFS	Blood	0.1258	0.0282	0.00000	0.077	0.095	0.090	0.089	0.085	5.2e-24	1.9e-29	5.4e-28	9.6e-28	2.3e-26
4	TCGA	Prostate Adenocarcinoma	0.0291	0.0218	0.00021	0.033	0.033	0.031	NA	0.032	1.9e-04	2.1e-04	3.3e-04	NA	2.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	3.6	5.7	7.0	2.6	2.6	1.5	-2.6
Bipolar Disorder or Schizophrenia	2.4	5.8	8.8	2.8	2.4	-0.8	-3.0
Depressed Affect (Nagel 2018)	2.8	5.9	15.8	2.2	4.0	-0.0	-1.7
Depression (Nagel 2018)	2.6	3.9	6.0	2.5	1.9	-1.0	-2.2
Intelligence (Savage-Jansen 2018)	1.2	3.8	13.2	-1.2	-0.6	-3.6	0.4
Neuroticism (Nagel 2018)	0.7	1.6	3.8	1.3	1.9	-0.7	-0.7
Schizophrenia (2018)	1.4	2.9	5.2	1.6	1.0	-2.3	-1.7
Schizophrenia vs Biploar Disorder	2.2	3.0	6.7	-2.0	-0.9	-2.6	0.5
Worry (Nagel 2018)	0.7	1.4	2.9	-0.2	-1.3	-0.9	1.7
Alzheimer’s Disease (in mother)	0.8	0.9	2.3	0.2	1.5	0.3	-1.1
Alzheimer’s Disease (in father)	0.8	0.9	1.8	-0.7	-1.4	-0.7	0.9
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.6	-0.1	-0.6	-0.4
Crohns Disease (2017)	10.6	23.2	31.5	5.5	5.6	1.5	-5.3
Irritable Bowel Disease (IBD)	8.9	21.2	39.8	4.5	6.3	0.9	-4.9
Ulcerative Colitis (UC)	3.6	6.8	18.7	1.7	4.3	-0.3	-2.4
Major Depression (MDD)	0.3	0.4	1.1	0.2	0.3	1.0	-0.4
Reaction Time	0.8	1.5	2.9	1.6	0.4	0.4	-1.7
Verbal and Numeric Reasoning (VNR)	1.2	2.9	5.1	-2.2	-0.7	-2.3	1.1
Breast Cancer	9.2	22.1	34.6	-5.9	-4.9	2.4	4.9
Ovarian Cancer	0.5	0.7	1.3	0.6	0.6	1.1	-0.8
Prostate Cancer	1.7	2.4	8.3	-0.1	0.9	-2.9	-0.4
Age at First Birth	2.3	3.3	9.3	-0.4	-1.9	-3.0	-0.4
Bipolar Disorder (2011)	4.8	4.6	10.9	2.4	1.1	3.3	-0.7
Body Mass Index (BMI) (2010)	2.0	2.7	3.5	-1.5	-1.8	1.4	1.9
Coronary Artery Disease (CAD)	0.9	1.1	2.8	-0.8	-0.8	1.7	0.7
Crohns Disease (2012)	9.6	15.5	22.5	4.7	4.5	1.0	-4.3
Mean Putamen Volume	2.6	2.9	5.4	1.2	2.3	-0.5	-2.1
Fasting Glucose	1.0	1.2	3.6	0.4	1.9	-0.3	-1.0
HbA1C	0.3	0.4	0.8	-0.7	0.9	0.3	-0.4
HDL Cholesterol	0.8	1.3	2.7	-1.0	-1.2	-0.0	1.6
LDL Cholesterol	2.3	3.6	10.8	0.3	3.3	0.6	-1.8
Lupus	0.0	0.0	0.1	0.2	0.1	0.2	0.1
Neuroticism (2016)	0.1	0.1	0.6	0.0	0.2	-0.0	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.8	0.4	-0.5	-0.8
Rheumatoid Arthritis	0.6	0.9	1.7	-0.9	0.3	1.3	0.9
Schizophrenia (2014)	1.9	4.2	7.0	1.7	1.0	-2.7	-2.4
Triglycerides	0.5	0.8	1.3	0.3	1.1	0.9	-1.1
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.4	0.6	1.2	-1.6	-0.6
Ulcerative Colitis	1.5	2.2	6.2	1.0	2.5	-0.8	-0.9
Blood Eosinophil Count	0.6	4.6	14.4	-0.0	0.1	3.8	1.9
Blood Platelet Count	2.2	26.0	50.8	3.6	7.1	6.0	-2.0
Blood Red Count	1.4	13.1	41.6	1.0	6.5	3.1	0.0
Blood White Count	3.2	23.4	67.1	4.3	2.1	8.2	-1.9
Heel T-Score	0.7	5.4	12.6	1.2	-3.5	2.1	-1.8
BMI	1.1	6.3	13.9	0.6	-3.7	2.9	1.5
Height	0.6	12.1	43.8	1.1	-1.1	-6.6	-1.5
Waist Hip Ratio (WHR)	1.3	5.7	14.7	2.7	3.8	-0.3	-1.0
Systolic Blood Pressure	0.6	2.9	9.4	-1.0	0.0	-3.1	-1.0
Smoking Status	1.7	4.0	6.6	1.8	2.6	0.8	-2.4
Allergy or Eczema	2.6	6.7	10.2	2.6	3.1	-0.4	-3.2
Cardiovascular Disease	0.7	2.4	6.6	1.0	1.3	-0.5	-2.6
Hypothyroidism (self reported)	0.4	0.9	2.0	-1.1	-1.4	-0.5	-0.2
Respiratory disease	3.3	7.3	15.1	3.9	2.3	1.6	-2.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.9	0.6	2.4	-0.4	-0.1
Lung FEV1/FVC ratio	0.2	1.1	3.6	-0.4	-1.9	-0.1	0.7
Lung FVC	2.0	10.0	14.8	-2.9	-3.9	-2.9	3.0
Neuroticism	0.9	2.1	4.8	1.9	2.2	-0.0	-0.2
Chronotype (morning person)	0.1	0.3	1.1	0.2	1.0	-0.1	-0.4
Hair Pigment	1.0	27.8	65.1	4.3	8.1	-0.4	-5.2
Tanning	1.3	15.4	27.6	3.8	4.4	0.6	-5.2
Hand grip strength (left)	0.4	1.0	1.9	0.3	1.2	-1.4	-0.8
Number of treatments/medications taken	1.0	1.8	4.0	1.7	0.2	2.0	-0.5
Average weekly spirits intake	0.6	0.7	1.7	-0.7	-1.3	-0.5	-0.6
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Frequency of depressed mood in last 2 weeks	3.5	4.9	7.0	2.6	2.3	-1.6	-2.2
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.2	-0.5	0.5	-0.3
Relative age of first facial hair	0.4	0.9	1.9	1.2	0.2	-0.0	-1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	5.5	2.4	0.8	-0.3	-1.0
Ever used hormone-replacement therapy (HRT)	2.9	3.7	9.5	-3.1	-2.1	0.0	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.9	-0.3	-1.4	0.6	0.6
Systolic blood pressure, automated reading	0.9	2.6	5.6	-0.8	-2.1	-2.4	0.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	-0.1	-1.1	1.4	1.0
Angina	0.4	0.5	1.9	0.2	0.3	1.4	0.2
Medication for hormone replacement therapy	1.7	1.9	3.8	-1.9	-1.6	1.1	-0.0
Vitamin and mineral supplements	0.3	0.4	1.3	0.2	1.1	-0.3	-0.3
Supplements: Zinc	0.4	0.5	1.1	-0.4	0.2	1.1	0.8
Medication: Co-codamol	0.6	0.7	1.8	-0.2	-0.7	1.4	0.5
Medication: Metformin	0.5	0.7	2.3	0.7	1.5	0.3	0.4
Diabetes (father)	0.3	0.4	0.8	0.9	0.1	0.6	-0.7
Diabetes (mother)	1.1	1.4	4.0	2.0	1.0	-0.6	-0.5
Severe depression (siblings)	2.1	2.4	5.7	2.4	1.3	0.5	-1.3
Pack years adult smoking proportion	1.0	1.5	4.4	0.8	-1.0	2.1	-0.1
Impedance of leg (right)	3.1	15.1	39.9	2.4	6.3	-1.2	-3.6
Leg fat-free mass (left)	1.1	6.0	16.9	-0.3	-4.1	-1.6	2.1
Trunk fat percentage	1.2	4.8	9.6	2.5	-3.1	1.7	0.5
Hand grip strength (right)	0.3	0.7	2.4	0.1	0.5	-1.5	-0.3
Townsend deprivation index at recruitment	1.5	2.1	4.0	0.8	1.8	2.0	-0.7
Current tobacco smoking	3.6	5.9	11.2	3.3	0.9	2.2	-2.6
Average weekly fortified wine intake	0.3	0.4	1.0	-0.1	-1.0	0.7	-0.3
Maternal smoking around birth	0.6	0.9	2.0	1.0	0.6	-0.5	-1.4
Fed-up feelings	1.4	2.6	8.0	1.1	2.8	-0.3	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	5.5	2.4	1.9	-0.5	-1.5
Relative age voice broke	0.7	1.1	3.0	1.0	0.5	0.6	-1.7
Taking other prescription medications	0.9	1.3	3.0	1.7	-0.5	1.5	-0.2
Age when periods started (menarche)	0.5	1.3	3.6	1.9	0.8	0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.1	-1.2	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.4	1.3	-2.3	1.8	-0.9
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.0	-1.1	0.0	1.0	2.0
Qualifications: CSEs or equivalent	1.9	2.6	3.6	1.6	1.2	-1.6	-1.9
Serious illness, injury or assault to yourself	0.5	0.6	1.5	1.2	0.8	0.7	-0.2
High blood pressure	0.7	2.0	3.6	0.9	0.5	-1.9	-1.8
Hayfever, allergic rhinitis or eczema	3.0	6.5	10.6	2.5	3.2	-0.6	-3.0
Multivitamins +/- minerals	0.5	0.7	2.4	0.5	-1.5	0.2	0.2
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.1	0.3	0.2	0.4
Supplements: Glucosamine	0.9	1.2	2.6	-1.4	-1.6	-0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	0.1	-1.3	-0.9	0.8
Medication: Atenolol	0.4	0.5	1.2	1.1	-0.9	0.2	-0.3
Medication: Levothyroxine sodium	0.4	0.6	1.6	-1.3	-0.8	0.1	0.6
Sitting height	0.9	6.3	23.7	-0.2	1.1	-4.9	-0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.1	0.2	0.2	0.5
High blood pressure (mother)	4.2	5.9	9.0	-2.0	-3.0	-2.3	2.3
Body mass index (BMI)	1.0	4.4	13.8	0.6	-3.7	1.4	1.2
Impedance of leg (left)	3.0	14.6	38.6	2.4	6.2	-0.7	-3.7
Leg predicted mass (left)	1.2	6.1	17.0	-0.4	-4.1	-1.5	2.2
Trunk fat mass	0.9	4.1	10.6	2.2	-3.3	0.7	0.6
Waist circumference	0.4	1.4	4.4	2.1	-1.0	0.3	-0.1
Number of incorrect matches in round	0.3	0.5	1.3	1.1	-0.4	-0.7	-0.5
Past tobacco smoking	2.7	5.0	18.9	-0.0	-4.3	0.2	1.0
Alcohol usually taken with meals	0.5	0.8	3.1	-0.3	0.1	-1.8	-0.2
Nervous feelings	2.0	3.7	7.6	-1.0	-2.8	-0.3	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.7	2.4	1.4	-0.6	-1.4
Hearing difficulty/problems with background noise	0.2	0.2	0.4	-0.5	0.7	0.5	0.2
Hair/balding pattern: Pattern 2	1.8	2.3	4.7	1.4	1.4	0.8	-2.2
Had menopause	0.2	0.3	0.5	-0.7	-0.3	-0.0	0.7
Had other major operations	1.3	1.6	4.2	2.0	-0.5	-0.4	-1.4
Forced vital capacity (FVC)	0.8	3.2	7.0	-1.3	-1.6	-2.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	2.9	1.6	-1.5	1.7	-1.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.1	-0.0	0.6	-0.2
Qualifications: None of the above	0.3	0.6	1.7	-0.0	-0.0	1.3	0.7
Financial difficulties in last 2 years	0.3	0.3	1.3	0.2	-0.3	-0.0	1.1
Mouth/teeth dental problems	5.1	7.8	21.9	-1.9	-4.7	-2.2	0.9
Heart attack	0.5	0.7	1.9	0.8	0.1	1.4	-0.4
Allergy	3.6	8.4	13.9	-3.4	-3.7	0.1	2.9
Pain all over the body in last month	2.0	2.1	4.0	0.8	-0.7	1.8	2.0
Diabetes (self-reported)	1.0	1.6	4.6	1.1	2.1	-0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.5	1.6	1.6	-0.0	-1.4
Medication: Ramipril	4.9	6.3	13.4	2.1	2.5	-1.1	-3.7
Medication: Simvastatin	0.4	0.5	1.5	1.2	0.8	-0.1	-0.1
Fluid intelligence score	0.4	0.8	1.9	-1.4	-0.3	-1.0	0.3
Illnesses of siblings	0.4	0.5	2.1	-0.1	0.2	1.4	0.0
Neuroticism score	0.6	1.2	2.9	1.2	1.7	-0.6	-0.3
Weight	0.7	3.6	11.5	1.1	-3.4	-1.0	0.8
Impedance of arm (right)	0.2	1.1	1.4	1.1	-0.9	1.2	0.9
Arm fat percentage (right)	1.9	7.7	18.9	1.4	-4.3	2.5	2.0
Trunk fat-free mass	0.9	5.0	15.4	-1.0	-1.7	-3.9	1.0
Hip circumference	0.5	2.3	8.5	0.7	-2.9	-0.2	0.3
Time employed in main current job	2.3	2.7	4.8	-1.1	-2.2	0.9	2.0
Alcohol intake versus 10 years previously	0.4	0.7	2.3	0.3	0.2	1.5	-0.5
Father’s age at death	0.4	0.6	1.1	-0.4	0.4	0.9	1.0
Worrier / anxious feelings	1.2	2.3	6.5	-0.3	-1.6	-0.2	2.5
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	6.4	2.5	1.2	0.0	-1.7
Falls in the last year	0.2	0.3	0.9	-0.0	0.6	-0.1	-1.0
Hair/balding pattern: Pattern 3	1.1	1.6	3.5	-1.6	-0.3	-0.4	1.9
Number of live births	0.7	0.9	3.0	0.5	1.7	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	6.0	-1.5	-2.3	-2.5	1.1
Pulse rate	0.2	0.3	0.8	0.3	-0.3	0.4	-0.9
Happiness	0.3	0.4	1.0	-0.5	1.0	0.1	-0.4
Noisy workplace	0.3	0.3	1.1	1.1	0.1	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.7	-1.3	-0.2	0.3	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.9	0.3	-0.0	-0.6
Mouth/teeth dental problems: Dentures	4.3	7.3	22.9	1.9	4.8	1.1	-1.2
Asthma	2.5	5.0	9.1	3.0	1.9	1.4	-2.2
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	8.2	-2.6	-2.3	-0.8	2.9
Medication: Cholesterol lowering	1.1	1.8	5.2	0.9	2.3	0.2	-1.0
Depression (self-reported)	1.0	1.2	3.3	1.8	0.8	-0.4	-0.8
Medication: Lansoprazole	2.5	2.9	5.4	1.8	1.5	2.3	-0.6
Prospective memory result	0.3	0.4	0.8	0.3	-0.9	0.7	-0.2
Lung cancer (father)	0.5	0.6	1.4	0.8	1.2	0.3	-0.5
Illnesses of mother	1.0	1.3	3.1	0.4	0.9	1.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	7.2	-2.0	-2.2	-2.7	1.4
Pulse wave Arterial Stiffness index	1.8	2.0	3.2	1.3	1.3	-1.3	-1.8
Impedance of arm (left)	0.3	1.5	2.5	1.6	-1.1	1.4	0.5
Arm fat mass (right)	1.3	5.4	16.3	1.2	-4.0	1.1	1.6
Trunk predicted mass	0.9	4.9	15.3	-1.0	-1.6	-3.9	0.9
Standing height	0.8	8.4	32.7	0.8	0.1	-5.7	-0.5
Length of working week for main job	1.0	1.1	1.8	1.3	1.1	1.1	0.3
Exposure to tobacco smoke at home	0.5	0.6	1.3	-0.6	-0.2	-0.8	1.1
Breastfed as a baby	1.3	1.6	2.8	1.4	1.1	0.6	-1.7
Tense / ‘highly strung’	1.3	2.2	4.0	1.5	2.0	-0.6	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	-0.6	-0.0	-0.5
Hair/balding pattern: Pattern 4	0.8	2.0	5.9	-0.6	-2.4	-0.5	1.2
Birth weight of first child	0.1	0.3	0.9	0.0	-0.4	-0.1	0.9
Peak expiratory flow (PEF)	1.1	2.6	7.7	-1.2	-2.8	-0.9	0.8
Pulse wave reflection index	2.4	2.9	6.9	1.1	2.6	-0.9	-1.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.0	1.4	-0.1	1.1	-0.7
Loud music exposure frequency	1.1	1.2	3.0	-0.7	-1.7	0.4	1.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.6	-1.2	-0.9	-1.0	0.5
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	5.2	1.6	2.3	2.0	-0.4
Blood clot in the leg (DVT)	1.8	2.4	5.7	1.4	2.4	0.7	-1.1
Medication: Paracetamol	1.3	2.2	4.2	-0.6	-0.3	2.1	2.0
Headache pain in last month	0.1	0.2	0.3	0.5	-0.3	0.5	0.3
Medication for cholesterol, blood pressure or diabetes	3.4	5.7	9.5	-2.6	-3.1	-0.0	2.6
Glaucoma (self-reported)	0.2	0.2	0.7	0.1	0.3	-0.8	-0.2
Gout (self-reported)	1.8	2.5	7.9	0.9	-2.8	-1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.7	-1.1	-1.6	0.2	1.0
Medication: Amlodipine	0.1	0.1	0.3	-0.5	0.5	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.9	0.7	1.4	1.3	-0.3
Birth weight	2.4	5.1	8.5	-1.5	-1.1	2.9	2.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.9	1.1	-0.4	-0.7
High blood pressure (siblings)	0.6	0.8	2.6	0.1	-0.8	-1.6	0.3
Forced vital capacity (FVC), Best measure	0.9	3.4	8.3	-1.4	-1.4	-2.9	1.3
Body fat percentage	1.0	4.0	6.6	2.5	-2.6	1.8	0.3
Leg fat percentage (right)	0.6	2.3	6.5	2.6	-0.5	1.2	-1.1
Arm fat-free mass (right)	0.5	2.6	10.1	0.2	-0.5	-3.2	-0.1
Exposure to tobacco smoke outside home	0.2	0.2	0.6	0.3	0.3	-0.3	-0.8
Comparative body size at age 10	2.3	6.2	14.8	-1.2	-1.7	3.9	2.4
Number of full brothers	3.2	4.0	8.2	2.0	2.0	-0.2	-2.9
Worry too long after embarrassment	0.5	0.8	2.1	0.3	1.5	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	8.1	2.8	2.5	-0.4	-1.8
Wheeze or whistling in the chest in last year	2.6	4.7	10.2	2.2	3.2	0.7	-1.8
Number of children fathered	0.6	0.6	1.3	0.0	-0.9	-0.5	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.1	0.2	-0.1	-0.1	-1.0
Age at first live birth	1.3	2.4	4.9	-2.2	-0.8	-1.0	1.7
Pulse wave peak to peak time	1.5	1.8	3.4	-1.2	-1.3	0.7	1.9
Health satisfaction	0.8	1.0	1.6	-1.2	-1.0	-0.3	1.2
Shortness of breath walking on level ground	0.7	0.9	2.5	-0.6	-0.7	-0.1	1.6
Qualifications: College or University degree	1.3	4.2	8.5	-2.9	-1.5	-1.3	2.1
Eye problems/disorders: None of the above	1.4	1.6	4.1	-0.7	-2.0	-0.9	1.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.8	1.4	1.7	0.3	-1.1
Emphysema/chronic bronchitis	2.7	3.0	6.0	1.9	2.5	1.4	-0.8
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	0.1	0.5	-1.3	-1.4
Neck or shoulder pain in last month	0.5	0.7	1.2	-1.1	-0.4	-0.7	0.9
Medication: Blood pressure	2.6	4.5	7.5	1.8	2.7	-1.0	-2.5
Angina (self-reported)	0.3	0.4	1.2	-0.1	0.2	1.1	0.4
Migraine (self-reported)	0.9	1.2	2.3	-1.1	-1.1	-0.1	1.5
Medication: Ibuprofen	3.7	4.4	7.2	-2.7	-1.7	-0.7	2.7
Medication: Allopurinol	1.2	1.6	4.8	1.0	-2.2	-0.7	0.1
Medication: Omeprazole	0.6	0.7	2.8	-0.0	1.7	0.1	0.0
Medication: Seretide 50 evohaler	0.6	0.7	1.9	0.9	1.4	0.0	-0.1
Mean time to correctly identify matches	0.9	1.7	2.9	1.7	0.3	0.9	-1.7
Heart disease (mother)	1.6	1.9	4.2	-1.1	-0.6	1.4	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.2	5.0	8.4	1.7	2.9	-1.0	-2.8
Whole body fat mass	0.8	3.3	9.0	1.9	-3.0	0.6	0.6
Leg fat mass (right)	0.5	2.0	5.2	2.3	-1.5	0.7	-0.3
Arm predicted mass (right)	0.5	2.6	9.8	0.1	-0.7	-3.1	-0.1
Pulse rate, automated reading	0.3	1.0	2.2	-0.6	-1.5	0.9	1.0
Alcohol intake frequency.	0.8	1.9	4.2	1.3	-0.8	2.0	0.9
Comparative height size at age 10	0.8	4.4	16.8	0.2	-0.1	-4.1	0.7
Number of full sisters	0.8	0.9	2.7	0.6	0.4	-0.8	-1.7
Suffer from ‘nerves’	0.5	0.8	2.6	-0.4	-0.2	-1.6	0.6
Overall health rating	0.4	0.9	2.7	1.6	-0.4	0.1	0.9
Chest pain or discomfort	3.5	5.1	7.7	2.8	2.6	1.4	-2.0
Had major operations	0.3	0.4	1.1	0.5	1.1	0.5	-0.1
Age at last live birth	2.3	3.3	8.4	-1.9	0.2	-2.9	1.2
Family relationship satisfaction	1.1	1.4	3.1	0.4	1.8	-0.2	-1.5
Leg pain on walking	0.4	0.5	1.0	-0.8	-0.4	0.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.7	0.6	1.1	0.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.5	0.7	0.7	0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.8	-0.2	-0.9	-0.1
Medication: Aspirin	0.9	1.2	2.1	1.5	1.1	1.0	-0.7
Supplements: Vitamin C	0.6	0.7	1.3	-1.0	0.5	-0.2	1.1
Knee pain experienced in last month	0.9	1.5	4.3	-0.7	-2.1	-0.6	0.8
Hypertension (Self-reported)	1.0	2.7	4.8	1.4	1.0	-1.8	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.9	1.1	0.9	1.4	-0.6
Illnesses of father: Heart disease	1.2	1.7	4.7	0.3	-2.2	-1.4	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	2.9	0.3	0.4	1.7	0.6
Smoking status: Previous	3.6	5.4	19.7	-0.6	4.4	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-0.7	-0.2	-1.1	0.5
Whole body fat-free mass	0.8	4.6	9.4	-0.7	-2.6	-3.1	1.4
Leg fat-free mass (right)	1.3	6.8	19.9	-0.6	-4.5	-1.4	2.3
Arm fat percentage (left)	1.9	7.7	19.8	1.6	-4.5	2.4	1.6
Average weekly red wine intake	0.9	1.3	3.2	-1.2	0.5	-1.8	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.1	-0.2	0.9	-0.1
Mood swings	1.1	2.0	6.0	1.2	2.4	-0.5	-0.5
Loneliness, isolation	1.9	2.6	6.2	1.7	2.5	0.1	-1.1
Long-standing illness, disability or infirmity	2.7	4.1	12.5	3.5	1.5	0.8	-1.0
Ever had bowel cancer screening	0.3	0.3	0.6	-0.8	0.2	-0.5	-0.6
Diabetes diagnosed by doctor	0.9	1.5	4.6	1.1	2.1	-0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	0.2	1.4	-0.2	-1.1
Friendships satisfaction	0.1	0.1	0.4	0.1	0.1	-0.2	-0.6
Qualifications: nursing, teaching	0.5	0.7	2.1	0.2	-0.8	1.5	0.2
Commuting to job workplace: Walk	0.6	0.7	1.2	-0.3	-1.1	-0.6	1.0
Eye problems/disorders: Cataract	0.7	0.8	1.4	0.4	1.2	-0.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.3
Medication for cholesterol	0.3	0.4	0.8	0.5	0.9	0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.8	3.7	-1.7	-1.9	-1.1	1.8
Back pain experienced in last month	3.2	4.7	12.2	-1.0	-2.3	-3.5	0.5
Mineral and other dietary supplements	0.1	0.2	0.3	0.3	0.5	0.0	0.5
Breast cancer (self-reported)	1.6	2.0	4.9	1.4	0.9	-0.3	-2.2
Asthma (self-reported)	3.1	6.1	11.3	3.4	2.1	1.5	-2.6
Osteoporosis (self-reported)	0.3	0.4	1.3	1.1	0.3	0.0	-0.1
Osteoarthritis (self-reported)	0.2	0.3	1.0	0.3	-0.2	0.3	1.0
Medication: Aspirin	1.5	1.9	2.9	1.7	1.5	1.3	-0.9
Medication: Gliclazide	2.3	2.7	8.6	0.9	2.9	0.8	-0.7
Illnesses of father: None of the above (group 1)	1.0	1.3	2.1	1.0	1.5	-0.2	-1.4
Smoking status: Current	2.6	4.2	8.9	3.0	0.5	1.9	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.4	-1.3	-1.9	-0.4	0.5
Whole body water mass	0.8	4.5	8.9	-0.7	-2.6	-3.0	1.4
Leg predicted mass (right)	1.3	6.8	19.6	-0.6	-4.4	-1.3	2.3
Arm fat mass (left)	1.3	5.3	16.7	1.3	-4.1	0.9	1.4
Number of self-reported non-cancer illnesses	1.5	2.5	6.2	2.5	1.2	0.5	-1.5
Average weekly champagne plus white wine intake	2.0	2.7	6.3	-0.9	-1.5	-2.5	1.2
Miserableness	2.6	4.5	9.9	1.9	3.1	-0.2	-2.1
Guilty feelings	2.7	4.1	6.8	2.1	1.4	-1.7	-2.6
Wears glasses or contact lenses	0.1	0.1	0.3	-0.1	-0.5	-0.5	-0.1
Ever taken oral contraceptive pill	1.0	1.1	3.6	0.2	-0.1	1.9	-0.9
Hearing aid user	0.1	0.1	0.2	0.2	-0.2	0.1	0.5
Mother’s age at death	0.6	0.7	1.5	-1.0	-0.1	-1.2	0.5
Financial situation satisfaction	1.5	1.8	2.8	1.2	1.7	-0.6	-1.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.8	-0.3	-0.0	-0.4
Commuting to job workplace: Public transport	1.0	1.2	2.4	-0.0	-1.6	0.1	1.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.5	0.0	0.6	0.1
Medication: Blood pressure	0.5	1.0	2.3	-0.0	-0.9	-1.5	-0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.7	0.4	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	0.1	-0.6	-0.4	-0.1
High cholesterol (Self-reported)	1.5	2.6	7.0	0.3	2.6	1.0	-1.6
Medication: Bendroflumethiazide	0.2	0.2	0.6	-0.1	0.1	-0.6	-0.7
Medication: Paracetamol	1.3	2.0	4.3	-0.5	-0.3	1.9	2.1
Medication: Lisinopril	0.1	0.1	0.4	-0.6	-0.0	-0.2	0.2
Medication: Atorvastatin	2.9	3.6	9.7	0.7	3.1	0.3	-2.0
Illnesses of father: High blood pressure	1.6	2.0	5.7	-2.4	0.1	-1.5	0.3
Alcohol drinker status: Never	0.4	0.5	0.8	-0.7	-0.9	-0.6	0.5
Ever smoked	1.4	2.4	8.8	-0.0	3.0	0.6	-0.7
Basal metabolic rate	0.8	4.2	8.8	-0.3	-3.0	-2.5	1.4
Leg fat percentage (left)	0.6	2.3	5.7	2.4	-0.7	1.4	-1.0
Arm fat-free mass (left)	0.5	2.6	8.7	-0.3	-1.1	-3.0	0.6
Number of operations (self-reported)	0.3	0.5	1.6	1.2	0.3	0.1	-0.6
Average weekly beer plus cider intake	0.4	0.5	1.8	-0.5	-0.1	0.0	1.3
Irritability	0.7	1.2	3.2	0.5	1.8	0.8	-0.8
Risk taking	1.7	2.5	5.3	0.8	2.3	-0.6	-1.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.7	-1.0	-1.3	-0.4	0.7
Fractured/broken bones in last 5 years	0.6	0.8	1.1	-0.1	1.1	-1.0	-1.1
Age started oral contraceptive pill	0.6	0.8	1.9	0.2	-0.3	1.0	1.4
Diastolic blood pressure, automated reading	1.2	3.7	8.5	-1.5	-2.9	-1.0	1.8
Ever depressed for a whole week	0.7	0.9	2.0	1.4	0.1	0.0	-1.2
Unable to work because of sickness or disability	1.0	1.2	3.4	1.8	0.4	0.9	-0.8
Commuting to job workplace: Cycle	0.4	0.4	0.9	0.9	0.3	-0.9	0.1
Myopia	1.5	2.2	6.2	-0.3	0.6	-2.5	-1.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.9	-1.3	-0.7	0.9	2.0
Cholesterol lowering medication	0.3	0.4	1.1	0.5	1.1	0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	0.5	1.1	0.4	0.1
Pain experienced in last month	4.0	6.7	12.2	2.2	3.5	0.1	-3.1
Supplements: Calcium	0.3	0.3	0.7	0.5	0.8	0.4	-0.4
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	-0.2	-0.8	0.3	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.4	0.6	-0.0	1.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	5.8	1.4	2.4	1.0	-1.2
Heart disease (siblings)	0.4	0.5	0.7	-0.7	-0.8	-0.3	0.8
Alcohol drinker status: Previous	1.8	2.0	4.2	1.5	1.2	0.3	-2.0
Pack years of smoking	0.6	0.9	2.7	0.9	-0.6	1.6	-0.1
Impedance of whole body	0.7	3.3	6.9	1.9	2.6	0.4	-1.6
Leg fat mass (left)	0.5	2.0	4.4	2.1	-1.8	0.6	-0.2
Arm predicted mass (left)	0.5	2.5	9.1	-0.2	-0.9	-3.0	0.4