TWAS hub - LMNA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0493	0.0147	1.0e-07	0.044	0.020	0.046	0.043	0.045	2.2e-14	2.1e-07	1.1e-14	5.7e-14	2.0e-14
2	TCGA	Colon Adenocarcinoma	0.0660	0.0370	8.8e-03	-0.004	0.009	-0.003	NA	-0.005	7.1e-01	9.1e-02	5.2e-01	NA	8.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood White Count	9.2	68.0	78.1	-8.8	-7.6
Age at last live birth	8.2	11.9	13.9	3.1	3.7
Age at First Birth	7.0	10.1	11.7	2.9	3.4
Prostate Cancer	5.0	7.0	8.1	2.9	2.4
Schizophrenia vs Biploar Disorder	4.6	6.0	8.0	2.8	2.0
Number of treatments/medications taken	4.5	8.1	8.6	-2.9	-2.7
Alcohol intake frequency.	4.3	10.0	14.0	-2.4	-3.7
Overall health rating	4.3	9.2	16.7	-1.3	-4.1
Myopia	4.3	6.2	8.2	2.9	2.0
Bipolar Disorder (2011)	3.6	3.5	7.0	-2.6	0.0
Blood Platelet Count	3.6	42.0	44.1	-6.6	-6.3
Pain all over the body in last month	3.6	3.8	5.7	-2.4	-1.4
Arm fat percentage (right)	3.3	12.9	16.4	-3.1	-4.0
Alcohol usually taken with meals	3.2	5.1	5.9	2.1	2.4
Mouth/teeth dental problems	3.1	4.7	8.5	2.9	1.0
Arm fat percentage (left)	3.1	12.3	14.5	-3.2	-3.8
Trunk fat percentage	3.0	11.9	17.1	-2.6	-4.1
Body fat percentage	3.0	12.0	15.7	-2.9	-4.0
Back pain experienced in last month	3.0	4.4	8.2	2.9	0.8
Medication: Co-codamol	2.8	3.3	3.5	-1.8	-1.9
Taking other prescription medications	2.8	4.3	4.3	-2.1	-2.1
Medication: Lansoprazole	2.8	3.2	6.0	-2.4	-0.7
Age at first live birth	2.8	4.9	5.7	2.0	2.4
Heart disease (mother)	2.8	3.4	6.2	-0.8	-2.5
Pack years adult smoking proportion	2.7	4.1	4.1	-2.0	-2.0
Schizophrenia (2014)	2.6	5.8	9.6	1.4	3.1
Length of working week for main job	2.6	2.8	4.5	-2.1	-1.1
Risk taking	2.6	3.8	7.6	0.2	2.8
Current tobacco smoking	2.5	4.1	4.8	-2.2	-1.8
Mother’s age at death	2.5	3.2	3.2	1.8	1.8
Leg fat percentage (left)	2.5	9.1	9.3	-3.0	-3.1
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	4.6	-0.6	-2.1
Standing height	2.4	23.5	38.3	6.2	3.0
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	3.4	1.9	1.5
Average weekly red wine intake	2.4	3.6	6.7	0.6	2.6
Medication: Aspirin	2.4	3.1	5.6	-2.4	-0.8
BMI	2.3	13.2	15.0	-3.4	-3.9
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	4.1	-2.0	-1.0
Medication for hormone replacement therapy	2.3	2.5	4.1	-2.0	1.0
Sitting height	2.3	16.3	20.9	4.6	3.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.3	10.8	3.3	1.9
Forced vital capacity (FVC), Best measure	2.3	8.3	12.3	3.5	2.1
Leg fat percentage (right)	2.3	8.3	9.3	-2.7	-3.1
Illnesses of siblings: Diabetes	2.3	2.9	5.5	-2.3	-0.5
Height	2.2	41.8	52.6	7.2	5.6
Diabetes (father)	2.2	2.7	4.4	-1.0	-2.1
Emphysema/chronic bronchitis	2.2	2.4	3.8	-1.9	-1.0
Medication for pain relief, constipation, heartburn	2.2	3.7	4.1	1.8	2.0
Angina	2.1	2.7	5.3	-2.3	-0.2
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	4.7	-2.2	-0.8
Medication: Ventolin 100micrograms inhaler	2.1	2.8	5.5	-0.2	-2.3
Comparative height size at age 10	2.1	11.5	22.4	4.7	0.8
Smoking status: Current	2.1	3.4	3.5	-1.9	-1.8
Guilty feelings	2.1	3.1	6.2	0.3	2.5
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	5.2	1.1	2.3
Chest pain or discomfort	2.0	2.9	4.2	-2.0	-1.2
Pack years of smoking	1.9	2.8	2.9	-1.7	-1.6
Intelligence (Savage-Jansen 2018)	1.8	5.5	8.4	2.9	1.6
Verbal and Numeric Reasoning (VNR)	1.8	4.4	7.1	2.7	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	6.8	-2.6	-1.1
Financial difficulties in last 2 years	1.8	2.4	3.9	-1.0	-2.0
Trunk predicted mass	1.8	10.2	12.2	3.5	2.9
Comparative body size at age 10	1.8	5.1	5.4	-2.2	-2.3
Angina (self-reported)	1.8	2.4	4.7	-2.2	-0.3
Long-standing illness, disability or infirmity	1.8	2.8	3.5	-1.4	-1.9
Type 2 Diabetes (T2D) (2012)	1.7	2.0	2.8	1.7	1.0
Forced vital capacity (FVC)	1.7	6.5	9.5	3.1	1.9
Trunk fat-free mass	1.7	9.6	11.9	3.5	2.7
Noisy workplace	1.7	2.0	3.3	-1.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	4.1	0.1	2.0
Medication: Aspirin	1.7	2.2	3.6	-1.9	-0.9
Handedness (chirality/laterality): Left-handed	1.7	2.1	2.3	-1.5	-1.4
Average weekly champagne plus white wine intake	1.7	2.3	3.8	1.9	0.9
Ever taken oral contraceptive pill	1.7	1.8	2.7	-1.6	-1.0
Medication: Atorvastatin	1.7	2.1	3.5	-1.9	-0.8
Unable to work because of sickness or disability	1.7	2.2	3.3	-1.1	-1.8
Body mass index (BMI)	1.6	6.9	8.4	-2.9	-2.3
Medication: Ramipril	1.6	2.1	3.9	-0.4	2.0
Exposure to tobacco smoke at home	1.6	1.8	3.3	0.5	-1.8
Commuting to job workplace: Cycle	1.6	1.9	3.3	1.8	0.7
Crohns Disease (2012)	1.5	2.3	4.2	-2.0	0.7
Respiratory disease	1.5	3.3	3.3	-1.8	-1.8
Trunk fat mass	1.5	6.4	10.0	-1.7	-3.2
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.4	6.2	-2.5	-0.8
Alcohol drinker status: Previous	1.5	1.7	1.8	-1.4	-1.2
Ulcerative Colitis	1.4	2.0	4.0	0.2	2.0
Allergy or Eczema	1.4	3.6	6.8	-0.6	2.6
Lung FVC	1.4	7.0	12.0	3.5	1.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.9	7.7	2.8	1.4
Mouth/teeth dental problems: Dentures	1.4	2.3	3.6	-1.9	-1.0
Arm fat mass (right)	1.4	5.8	7.4	-2.0	-2.7
Medication: Paracetamol	1.4	2.2	3.5	-1.9	-1.0
Illnesses of father: High blood pressure	1.4	1.8	3.2	0.6	1.8
Schizophrenia (2018)	1.3	2.7	4.7	0.9	2.2
Blood Eosinophil Count	1.3	9.9	11.6	-3.4	-2.9
Time employed in main current job	1.3	1.5	1.8	-1.1	-1.3
Alcohol intake versus 10 years previously	1.3	1.9	3.9	-2.0	0.1
Falls in the last year	1.3	1.7	2.9	0.7	-1.7
Qualifications: College or University degree	1.3	4.0	4.8	1.8	2.2
Whole body fat mass	1.3	5.4	7.7	-1.8	-2.8
Leg fat mass (right)	1.3	5.0	6.2	-1.9	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.1	-1.4	-1.0
Osteoporosis (self-reported)	1.3	1.7	3.3	-0.1	-1.8
Arm fat mass (left)	1.3	5.2	6.1	-2.1	-2.5
Bipolar Disorder or Schizophrenia	1.2	2.9	5.7	-0.3	2.4
Ovarian Cancer	1.2	1.6	3.1	-1.8	0.0
Body Mass Index (BMI) (2010)	1.2	1.7	2.8	-0.7	-1.7
Qualifications: None of the above	1.2	2.6	3.8	-1.2	-2.0
Heart attack	1.2	1.6	2.6	-1.6	-0.8
Medication: Cholesterol lowering	1.2	1.8	2.5	-1.6	-1.0
Qualifications: nursing, teaching	1.2	1.9	2.8	-1.0	1.7
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.8	-1.7	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.4	-1.5	-0.8
Leg fat mass (left)	1.2	4.7	5.9	-1.9	-2.4
Bipolar Disorder (2018)	1.1	1.7	2.6	-1.6	0.9
Ulcerative Colitis (UC)	1.1	2.1	4.1	0.1	2.0
Major Depression (MDD)	1.1	1.3	1.6	-1.1	-1.2
Multivitamins +/- minerals	1.1	1.4	2.8	-0.0	-1.7
Illnesses of siblings	1.1	1.5	2.5	-0.7	-1.6
High blood pressure (siblings)	1.1	1.5	2.4	0.8	1.6
Worry too long after embarrassment	1.1	1.9	2.8	0.9	1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.2	-0.7	-1.5
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.3	-0.2	2.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.0	-0.6	-1.4
Loud music exposure frequency	1.0	1.1	2.0	0.4	-1.4
Blood clot in the leg (DVT)	1.0	1.3	1.7	-1.3	-0.9
Glaucoma (self-reported)	1.0	1.1	1.5	0.9	-1.2
Medication: Ibuprofen	1.0	1.2	2.1	1.4	0.5
Suffer from ‘nerves’	1.0	1.6	3.1	1.8	0.2
Medication: Paracetamol	1.0	1.5	2.5	-1.6	-0.7
Supplements: Calcium	1.0	1.1	2.0	0.3	-1.4
Basal cell carcinoma (self-reported)	1.0	1.2	1.6	-0.9	-1.3
Crohns Disease (2017)	0.9	1.9	3.9	-2.0	0.1
Breast Cancer	0.9	2.2	3.0	-1.7	-1.2
Rheumatoid Arthritis	0.9	1.2	1.5	-1.2	-1.0
Townsend deprivation index at recruitment	0.9	1.3	1.4	-1.1	-1.2
Waist circumference	0.9	3.3	3.3	-1.8	-1.8
Hair/balding pattern: Pattern 2	0.9	1.2	2.2	-1.5	-0.3
Shortness of breath walking on level ground	0.9	1.1	1.8	1.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.5	1.9	0.2
High cholesterol (Self-reported)	0.9	1.7	2.1	-1.1	-1.4
Coronary Artery Disease (CAD)	0.8	0.9	1.8	-1.4	0.0
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.9	-0.2	1.4
Stomach or abdominal pain in last month	0.8	1.0	2.1	-0.1	-1.4
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.7	0.5	1.3
Impedance of arm (right)	0.8	3.6	7.1	0.4	-2.7
Birth weight	0.8	1.7	2.5	-1.6	-0.9
Arm fat-free mass (right)	0.8	4.3	4.9	1.9	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.9	-0.5	-1.4
Arm predicted mass (right)	0.8	4.3	4.3	2.1	2.1
Whole body fat-free mass	0.8	4.8	6.3	2.5	1.8
Mood swings	0.8	1.5	2.1	-1.0	-1.4
Whole body water mass	0.8	4.6	6.0	2.5	1.8
Ever smoked	0.8	1.4	2.1	-1.4	-0.9
Relative age voice broke	0.7	1.1	2.1	-1.4	-0.4
Serious illness, injury or assault to yourself	0.7	0.9	1.5	-1.2	-0.5
Nervous feelings	0.7	1.4	1.5	1.2	-1.2
Father’s age at death	0.7	0.9	1.1	0.8	1.1
Impedance of arm (left)	0.7	3.4	6.9	-0.0	-2.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	1.3	0.7
Eye problems/disorders: None of the above	0.7	0.8	0.8	0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.4	0.3	1.2
Illnesses of father: None of the above (group 1)	0.7	0.8	1.4	1.2	-0.4
Wears glasses or contact lenses	0.7	0.8	1.5	1.2	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.1	1.1	-0.8
Irritable Bowel Disease (IBD)	0.6	1.5	1.6	-1.2	1.3
Diabetes (mother)	0.6	0.7	0.9	-0.8	-0.9
Medication: Atenolol	0.6	0.8	1.4	-1.2	-0.3
Had other major operations	0.6	0.8	1.3	-0.5	-1.1
Fluid intelligence score	0.6	1.2	1.7	1.3	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.6	1.3	0.1
Peak expiratory flow (PEF)	0.6	1.4	2.8	1.7	0.2
Pulse wave reflection index	0.6	0.8	0.9	1.0	0.8
Pulse rate, automated reading	0.6	1.8	3.2	-1.8	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.1	-0.5	-1.1
Supplements: Vitamin C	0.6	0.7	0.8	0.8	0.9
Illnesses of father: Heart disease	0.6	0.8	1.6	-0.1	1.3
Commuting to job workplace: Walk	0.6	0.6	0.8	0.9	0.6
Breast cancer (self-reported)	0.6	0.8	1.0	0.7	1.0
Arm fat-free mass (left)	0.6	3.1	3.6	1.9	1.6
Arm predicted mass (left)	0.6	3.2	3.5	1.9	1.7
Alzheimer’s Disease (in mother)	0.5	0.6	0.8	0.6	-0.9
Triglycerides	0.5	0.8	1.0	-0.7	-1.0
Heel T-Score	0.5	3.7	6.4	-2.5	1.0
Cardiovascular Disease	0.5	1.6	2.8	-0.7	-1.7
Average weekly spirits intake	0.5	0.6	1.2	0.0	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	1.1	-0.7	-1.0
Severe depression (siblings)	0.5	0.6	0.8	-0.9	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	-0.9	-0.5
Medication: Simvastatin	0.5	0.7	1.3	-0.4	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	0.9	-0.9	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	1.2	0.5
Depression (self-reported)	0.5	0.6	0.9	-0.6	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-1.0	0.4
Health satisfaction	0.5	0.6	0.9	0.5	-0.9
Neck or shoulder pain in last month	0.5	0.7	1.3	-0.1	-1.1
Family relationship satisfaction	0.5	0.6	1.1	0.4	1.0
Asthma (self-reported)	0.5	1.0	1.8	-0.4	-1.3
Medication: Gliclazide	0.5	0.6	1.1	-1.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.7	0.8	1.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.3	-1.1	-0.7
Financial situation satisfaction	0.5	0.6	1.2	0.2	-1.1
Age started oral contraceptive pill	0.5	0.6	1.1	-1.0	-0.5
Cholesterol lowering medication	0.5	0.8	1.4	-0.4	-1.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	-1.2	-0.6
Worry (Nagel 2018)	0.4	0.8	1.5	1.2	-0.0
Lupus	0.4	0.5	1.0	0.3	1.0
Chronotype (morning person)	0.4	0.9	1.8	-0.2	-1.3
Sensitivity / hurt feelings	0.4	0.7	1.3	1.1	-0.2
Medication: Metformin	0.4	0.6	0.8	-0.6	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	1.0	1.0	0.2
Number of incorrect matches in round	0.4	0.6	0.8	0.9	0.6
Past tobacco smoking	0.4	0.7	0.8	0.9	0.7
Asthma	0.4	0.8	1.5	-0.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	-1.2	-0.2
Number of full brothers	0.4	0.5	0.5	-0.7	0.7
Wheeze or whistling in the chest in last year	0.4	0.7	0.8	-0.9	-0.8
Loneliness, isolation	0.4	0.5	1.0	-0.2	1.0
Ever had bowel cancer screening	0.4	0.5	0.6	0.8	0.7
Medication for cholesterol	0.4	0.6	1.0	1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	1.0	-0.1
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.4	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.6	-0.7	-0.5
Alcohol drinker status: Never	0.4	0.4	0.8	0.9	-0.3
Basal metabolic rate	0.4	2.1	3.0	1.7	1.1
Average weekly beer plus cider intake	0.4	0.5	1.0	0.1	-1.0
Irritability	0.4	0.7	1.0	-1.0	-0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	1.0	0.0
Depression (Nagel 2018)	0.3	0.5	1.0	-0.1	1.0
LDL Cholesterol	0.3	0.4	0.7	-0.9	-0.3
Smoking Status	0.3	0.8	1.1	-1.1	-0.7
Relative age of first facial hair	0.3	0.6	1.2	0.0	-1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.1	-0.8
Systolic blood pressure, automated reading	0.3	0.8	1.0	0.7	-1.0
Vitamin and mineral supplements	0.3	0.4	0.7	-0.1	0.9
Impedance of leg (right)	0.3	1.6	2.8	1.7	-0.6
Maternal smoking around birth	0.3	0.4	0.4	-0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	-0.4	0.8
Age when periods started (menarche)	0.3	0.6	0.7	-0.8	-0.8
Medication: Levothyroxine sodium	0.3	0.5	0.9	-1.0	-0.0
Number of live births	0.3	0.4	0.5	0.6	0.7
Pulse rate	0.3	0.6	0.7	-0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.4	1.2
Illnesses of mother	0.3	0.4	0.5	-0.5	0.7
Breastfed as a baby	0.3	0.3	0.5	-0.7	0.3
Headache pain in last month	0.3	0.6	0.7	0.8	-0.7
Medication: Amlodipine	0.3	0.5	0.9	0.1	-1.0
Medication: Omeprazole	0.3	0.3	0.4	-0.5	-0.7
Had major operations	0.3	0.4	0.7	-0.8	0.1
Leg pain on walking	0.3	0.3	0.5	-0.5	-0.7
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.8	0.1
Fractured/broken bones in last 5 years	0.3	0.4	0.9	0.9	-0.0
Diastolic blood pressure, automated reading	0.3	0.8	1.6	0.1	-1.3
Pain experienced in last month	0.3	0.4	0.7	-0.8	0.4
Heart disease (siblings)	0.3	0.3	0.6	0.8	0.2
Impedance of whole body	0.3	1.4	2.4	0.7	-1.6
Alzheimer’s Disease (in father)	0.2	0.2	0.2	0.4	-0.5
Fasting Glucose	0.2	0.2	0.3	0.6	-0.2
HDL Cholesterol	0.2	0.3	0.3	-0.6	-0.6
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.5	-0.7
Blood Red Count	0.2	1.6	3.1	-1.8	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.4	0.5	-0.6
Lung FEV1/FVC ratio	0.2	0.8	1.4	0.3	-1.2
Tanning	0.2	2.4	3.2	-1.8	1.2
Hand grip strength (left)	0.2	0.6	0.9	1.0	0.5
Supplements: Glucosamine	0.2	0.3	0.6	0.8	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.2	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	-0.2
Hip circumference	0.2	1.0	1.3	-0.8	-1.1
Worrier / anxious feelings	0.2	0.4	0.7	0.1	-0.8
Happiness	0.2	0.2	0.3	-0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.5	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.3	0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.0	0.8
Miserableness	0.2	0.3	0.6	-0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.7	-0.1
Number of operations (self-reported)	0.2	0.3	0.4	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.0	1.0	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.0	0.7
Mean Putamen Volume	0.1	0.1	0.2	-0.4	-0.3
Neuroticism (2016)	0.1	0.1	0.1	-0.1	0.4
Waist Hip Ratio (WHR)	0.1	0.6	0.8	-0.9	-0.7
Systolic Blood Pressure	0.1	0.7	0.7	0.8	-0.8
Hypothyroidism (self reported)	0.1	0.1	0.2	-0.5	-0.0
Hair Pigment	0.1	1.6	2.0	-1.1	1.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.4	-0.2
Leg fat-free mass (left)	0.1	0.7	1.2	1.1	0.3
Hand grip strength (right)	0.1	0.3	0.6	0.8	-0.2
Fed-up feelings	0.1	0.1	0.2	-0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	0.3
High blood pressure (mother)	0.1	0.1	0.1	0.3	0.4
Impedance of leg (left)	0.1	0.7	1.1	1.1	-0.6
Leg predicted mass (left)	0.1	0.6	1.2	1.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.5	-0.1
Had menopause	0.1	0.1	0.1	-0.0	-0.4
Allergy	0.1	0.2	0.3	0.4	-0.6
Diabetes (self-reported)	0.1	0.1	0.2	-0.2	-0.4
Neuroticism score	0.1	0.1	0.3	0.5	-0.2
Weight	0.1	0.5	0.9	-0.2	-1.0
Lung cancer (father)	0.1	0.1	0.2	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.3
Birth weight of first child	0.1	0.1	0.1	0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.1	-0.4
Number of children fathered	0.1	0.1	0.2	-0.1	0.5
Pulse wave peak to peak time	0.1	0.1	0.1	0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	-0.5
Medication: Blood pressure	0.1	0.1	0.1	-0.3	0.3
Medication: Allopurinol	0.1	0.2	0.3	-0.5	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.3
Knee pain experienced in last month	0.1	0.2	0.5	0.7	-0.0
Leg fat-free mass (right)	0.1	0.5	0.8	0.9	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.4	-0.6
Friendships satisfaction	0.1	0.1	0.2	-0.2	-0.4
Leg predicted mass (right)	0.1	0.4	0.7	0.8	0.5
Hearing aid user	0.1	0.1	0.3	0.2	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.1	-0.5
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	-0.4
Medication: Lisinopril	0.1	0.1	0.2	-0.3	0.4
Ever depressed for a whole week	0.1	0.1	0.3	-0.5	-0.1
Reaction Time	0.0	0.0	0.0	0.2	0.0
HbA1C	0.0	0.0	0.1	0.1	0.3
Neuroticism	0.0	0.1	0.1	-0.3	-0.2
Supplements: Zinc	0.0	0.0	0.0	0.0	0.1
Average weekly fortified wine intake	0.0	0.0	0.0	0.2	-0.0
High blood pressure	0.0	0.1	0.2	-0.2	0.4
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.1	0.3
Prospective memory result	0.0	0.0	0.0	0.0	0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.3	0.0
Tense / ‘highly strung’	0.0	0.1	0.1	-0.0	0.3
Gout (self-reported)	0.0	0.0	0.0	0.2	0.1
Migraine (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Mean time to correctly identify matches	0.0	0.0	0.1	-0.2	0.1
Number of full sisters	0.0	0.0	0.1	-0.1	0.3
Hypertension (Self-reported)	0.0	0.1	0.2	-0.3	0.4
Smoking status: Previous	0.0	0.0	0.1	-0.0	0.3
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.3	-0.1
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	-0.2
Medication: Blood pressure	0.0	0.0	0.0	-0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.1	-0.3

Hub : Genes

LMNA

Models

Trait associations