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chr10:49,201,820-51,094,660

Best TWAS P=1.3e-20 · Best GWAS P=1.1e-22 conditioned to 0.0021

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	VSTM4	0.15	0.00	lasso	3	0.00	4.1e-01	2.1	-6.4	1.9e-10	0.61	0.05	0.54	FALSE
2	GTEx	Colon Sigmoid	ARHGAP22	0.25	0.02	enet	28	0.03	2.9e-02	-2.0	-6.8	8.8e-12	0.52	0.05	0.71	FALSE
3	GTEx	Heart Left Ventricle	VSTM4	0.16	0.06	enet	12	0.08	5.8e-05	-8.8	7.1	9.8e-13	-0.71	0.06	0.91	FALSE
4	GTEx	Muscle Skeletal	VSTM4	0.07	0.04	lasso	2	0.03	5.6e-04	-7.7	7.7	1.0e-14	-0.80	0.12	0.76	FALSE
5	GTEx	Spleen	WDFY4	0.39	0.00	lasso	8	0.03	5.8e-02	-3.5	-7.1	1.5e-12	0.48	0.05	0.63	FALSE
6	GTEx	Spleen	VSTM4	0.46	0.19	lasso	6	0.23	1.2e-06	-7.3	-8.0	1.5e-15	0.82	0.12	0.86	FALSE
7	GTEx	Spleen	C10orf128	0.37	0.05	lasso	11	0.09	2.6e-03	-9.3	-6.1	1.1e-09	0.71	0.07	0.62	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf128	0.02	0.00	enet	7	0.01	2.7e-03	-6.8	-7.7	1.9e-14	0.63	0.04	0.14	FALSE
9	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf128	0.14	0.03	blup	60	0.06	9.1e-04	3.9	-6.9	5.4e-12	0.58	0.00	0.86	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	C10orf72	0.06	0.02	enet	7	0.05	1.3e-03	-7.0	9.0	1.7e-19	-0.81	0.01	0.88	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C10orf128	0.04	0.01	lasso	2	0.03	5.2e-04	-6.4	-6.6	4.3e-11	0.44	0.17	0.13	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM170B	0.09	0.10	blup	65	0.10	1.1e-11	-7.8	-8.3	1.1e-16	0.80	0.22	0.78	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	C10orf128	0.11	0.05	lasso	5	0.06	1.0e-07	-6.8	-7.8	4.1e-15	0.68	0.04	0.96	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C10orf128	0.05	0.02	blup	59	0.02	2.9e-03	-6.8	-7.5	6.1e-14	0.69	0.01	0.73	FALSE
15	The Cancer Genome Atlas	Soft Tissue Sarcoma	FAM170B	0.07	0.09	lasso	4	0.07	4.9e-05	-9.3	-9.3	1.3e-20	0.94	0.01	0.98	TRUE